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Pong Terrence T Cardiovascular Research Center, Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America ; School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, United States of America ; Harvard-MIT Division of Health Sciences & Technology, Cambridge, Massachusetts, United States of - - 2014
Myocardial infarction resulting from ischemia-reperfusion injury can be reduced by cardiac postconditioning, in which blood flow is restored intermittently prior to full reperfusion. Although key molecular mechanisms and prosurvival pathways involved in postconditioning have been identified, a direct role for eNOS-derived NO in improving regional myocardial perfusion has not been ...
Samoš Matej M Department of Internal Medicine I, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak Republic. Electronic address: - - 2014
Stent thrombosis is a morbid complication after percutaneous coronary intervention. Dual antiplatelet therapy significantly reduces stent thrombosis risk and forms currently the basis in acute ST elevation myocardial infarction pharmacologic treatment. The introduction of clopidogrel has made a major advance in the acute coronary syndrome treatment. However, there is growing ...
Muller Matthew D MD Penn State Hershey Heart and Vascular - - 2014
Forehead cooling activates the sympathetic nervous system and can trigger angina pectoris in susceptible individuals. However, the effect of forehead cooling on coronary blood flow velocity (CBV) is not well understood. In this human experiment, we tested the hypotheses 1) that forehead cooling reduces CBV (i.e., coronary vasoconstriction); and 2) ...
Pavo Noemi N Department of Cardiology, Medical University of Vienna, - - 2014
The quantity of cells with paracrine effects for use in myocardial regeneration therapy is limited. This study investigated the effects of catheter-based endomyocardial delivery of secretome of 2.5 × 10(9) apoptotic peripheral blood mononuclear cells (APOSEC) on porcine chronic post-myocardial infarction (MI) left ventricular (LV) dysfunction and on gene expression. Closed-chest reperfused ...
Cardoso Luis L Department of Biomedical Engineering, The City College of The City University of New York, New York, USA; The Graduate Center of The City University of New York, New York, NY, - - 2014
Approximately half of all cardiovascular deaths associated with acute coronary syndrome occur when the thin fibrous cap tissue overlying the necrotic core in a coronary vessel is torn, ripped or fissured under the action of high blood pressure. From a biomechanics point of view, the rupture of an atheroma is ...
Dai Wangde W 1The Heart Institute, Good Samaritan Hospital, and Division of Cardiovascular Medicine of the Keck School of Medicine, University of Southern California, Los Angeles, CA, USA Guest editor was Dr. Michael - - 2014
Although numerous studies demonstrated that localized delivery of either cells or biomaterials improved postinfarction cardiac function, the underlying mechanisms for this effect remain unclear. We performed a comparison of the effects of fetal, neonatal, and human embryonic stem cell-derived cardiac cell as well as mesenchymal stem cell transplantation versus biomaterial ...
Andrukhova Olena O Biomedical Sciences, University of Veterinary Medicine, Vienna, - - 2014
Heart failure (HF) is a common and often fatal complication of myocardial infarction (MI). Glutathione S-transferase P1-1 (GSTP1) has anti-apoptotic, anti-inflammatory effects and is a specific serum marker in HF patients. However, its role in HF treatment is unknown. GSTP1 effect was examined in rat MI-induced HF model. Magnetic resonance ...
Krenn Lisa L Department of Cardiology, WahringerGürtel 18-20, A-1090 Vienna, - - 2014
Objectives. Cost-effectiveness of percutaneous coronary intervention (PCI) using drug-eluting stents (DES) and coronary artery bypass surgery (CABG) was analysed in patients with multivessel coronary artery disease over a 5-year follow-up. Background. DES implantation reducing revascularization rate and associated costs might be attractive for health economics compared to CABG. Methods. Consecutive ...
Jiang Jiangtao J Key Laboratory of Xinjiang Endemic Phytomedicine Resources, Ministry of Education, School of Pharmacy, Shihezi University, Beierlu, Shihezi, 832002, Xinjiang, - - 2014
This study evaluates antioxidative and cardioprotective effects of total flavonoids extracted from Dracocephalum moldavica L. (DML). The total flavonoids showed remarkable scavenging effects against 1,1-diphenyl-2-picrylhydrazyl, hydroxyl and superoxide anion radicals in vitro. Compared with the ischemia/reperfusion (I/R) group as demonstrated by the use of improved Langendorff retrograde perfusion technology, the total ...
Toeg Hadi Daood HD aDivision of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada bDivision of Cardiac Surgery, Harvard University, Massachusetts General Hospital, Boston, Massachusetts, - - 2014
This article aims to review contemporary studies that utilized mechanical circulatory support (MCS) in the treatment of heart failure and to elaborate on prospective mechanical alternatives. There is a growing need for a well-tolerated, durable and effective MCS option in patients with refractory heart failure. In previous years, the primary ...
Kereiakes Dean J DJ The Lindner Research Center, The Christ Hospital Heart and Vascular Center, Cincinnati, - - 2014
Coronary revascularization may be performed for relief of anginal symptoms or, in specific patient subgroups, to reduce the incidence of myocardial infarction and mortality. Achieving complete revascularization of all significantly obstructed coronary segments has been an established goal of coronary bypass graft surgery (CABG) and more recent data demonstrate a ...
Wang Miao M Department of Epidemiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, - - 2014
The cost-effectiveness of the optimal use of hospital-based acute myocardial infarction (AMI) treatments and their potential impact on coronary heart disease (CHD) mortality in China is not well known. The effectiveness and costs of optimal use of hospital-based AMI treatments were estimated by the CHD Policy Model-China, a Markov-style computer ...
Codolosa J Nicolás JN Einstein Center for Heart and Vascular Health, Einstein Medical Center, Philadelphia, PA, - - 2014
Mortality rates attributable to coronary heart disease have declined in recent years, possibly related to changes in clinical presentation patterns and use of proven secondary prevention strategies. Chronic stable angina (CSA) remains prevalent, and the goal of treatment is control of symptoms and reduction in cardiovascular events. Ranolazine is a ...
Bagi Zsolt - - 2014
It is believed that obesity has detrimental effects on the coronary circulation. These include immediate changes in coronary arterial vasomotor responsiveness and the development of occlusive large coronary artery disease. Despite its critical role in regulating myocardial perfusion, the altered behavior of coronary resistance arteries, which gives rise to coronary ...
Tseliou Eleni E Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of - - 2014
We sought to understand the cellular and tissue-level changes underlying the attenuation of adverse remodeling by cardiosphere transplantation in acute myocardial infarction (MI). Cardiospheres (CSps) are heart-derived multicellular clusters rich in stemness and capable of multilineage differentiation. Post-MI CSp transplantation improves left ventricular (LV) function and attenuates remodeling in both ...
Keene Daniel D International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College London, London W2 1LA, UK - - 2014
To investigate the effects on cardiovascular outcomes of drug interventions that increase high density lipoprotein levels. Meta-analysis. Therapeutic benefit of niacin, fibrates, and cholesteryl ester transfer protein (CETP) inhibitors on cardiovascular events (all cause mortality, coronary heart disease mortality, non-fatal myocardial infarction, and stroke). 117,411 patients were randomised in a ...
Marleau Sylvie S Faculté de Pharmacie, Université de Montréal, Montréal, Qué., - - 2014
Atherosclerosis is the main underlying cause of ischemic heart disease and related acute cardiovascular complications, including myocardial infarction and stroke. In view of the failure of statins to demonstrate a beneficial effect in all patients, exhaustive research efforts have unfold into different research avenues, in close relation to the increase ...
Dziewierz Artur A 2nd Department of Cardiology, Jagiellonian University Medical College, Krakow, - - 2014
Introduction of antiplatelet agents has contributed substantially to improve the outcome of patients with acute coronary syndromes. Meta-analysis of the studies on abciximab administration during primary percutaneous coronary intervention (PCI) for acute ST-segment elevation myocardial infarction (STEMI) has clearly confirmed the mortality benefit associated with intravenous bolus and infusion of ...
Maslov Leonid N LN The Laboratory of Experimental Cardiology, Research Institute of Cardiology, Siberian Branch, Russian Academy of Medical Sciences, Tomsk, - - 2014
The objective of this study was to investigate the role of peripheral μ, δ1, δ2, and nociceptin opioid receptors agonists in the regulation of cardiac tolerance to the arrhythmogenic effect of ischemia/reperfusion in rats. Anesthetized open-chest male Wistar rats were subjected to either 45 minutes of left coronary artery occlusion (phase ...
Tokudome Takeshi T Department of Biochemistry, Suita, - - 2014
Ghrelin is a peptide that was originally isolated from the stomach. It exerts potent growth hormone (GH)-releasing and orexigenic activities. Several studies have highlighted the therapeutic benefits of ghrelin for the treatment of cardiovascular disease. In animal models of chronic heart failure, the administration of ghrelin improved cardiac function and ...
Osadchii Oleg E OE Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Health Science and Technology, University of Aalborg, Aalborg, - - 2014
Normal hearts exhibit a positive time difference between the end of ventricular contraction and the end of QT interval, which is referred to as the electromechanical (EM) window. Drug-induced prolongation of repolarization may lead to the negative EM window, which was proposed to be a novel proarrhythmic marker. This study ...
Li Yu Hong YH State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, P. R. China; Ministry of Education Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Tianjin University of Traditional Chinese Medicine, Tianjin, P. R. China; Institute of Traditional Chinese Medicine Research, Tianjin University of Traditional Chinese Medicine, Tianjin, - - 2014
Shen Fu Injection (SF), which consisted of Red ginseng extraction injection (RG) and prepared aconite extraction injection (RA), is a traditional Chinese medicine mainly used for various cardiac diseases. This study is to analyse SF's effects on cardiac performance and coronary circulation. And the coronary dilating effect and mechanism of ...
De Gennaro Luisa - - 2014
Statins are effective in the prevention of coronary events and the treatment of acute coronary syndromes. However, their efficacy and safety in patients with heart failure (HF) is still a matter of debate. On the basis of literature evidence from subgroup analysis, retrospective, prospective cohort studies, and randomized controlled trials, ...
Khan Tina Z TZ Royal Brompton and Harefield Hospital NHS Foundation Trust, Hill End Road, London, UB9 6JH, United - - 2014
It is increasingly recognised that lipoprotein(a) [Lp(a)], an inherited, genetically-determined form of LDL-cholesterol, is an independent cardiovascular risk factor and predictor of adverse cardiovascular outcomes. Lp(a) is felt to increase cardiovascular risk via its pro-thrombotic effect and by enhancing intimal lipoprotein deposition. Lipoprotein apheresis is currently the most effective treatment ...
Zhang Zheng Z Department of Cardiology, The Second Artillery General Hospital of Chinese People's Liberation Army, Beijing, - - 2014
Nebivolol, third-generation β-blocker, may activate β3-adrenergic receptor (AR), which has been emerged as a novel and potential therapeutic targets for cardiovascular diseases. However, it is not known whether nebivolol administration plays a cardioprotective effect against myocardial infarction (MI) injury. Therefore, the present study was designed to clarify the effects of ...
Kowalski William J WJ Cardiovascular Innovation Institute, University of Louisville Louisville, KY, USA ; Department of Pediatrics, University of Louisville Louisville, KY, - - 2014
Innovative research on the interactions between biomechanical load and cardiovascular (CV) morphogenesis by multiple investigators over the past 3 decades, including the application of bioengineering approaches, has shown that the embryonic heart adapts both structure and function in order to maintain cardiac output to the rapidly growing embryo. Acute adaptive ...
Gharanei M M Department of Biomolecular and Sport Sciences, Coventry University, Coventry, - - 2014
Doxorubicin is one of the most effective anti-cancer agents. However, its use is associated with adverse cardiac effects, including cardiomyopathy and progressive heart failure. Given the multiple beneficial effects of the mitochondrial division inhibitor (mdivi-1) in a variety of pathological conditions including heart failure and ischaemia-reperfusion injury (IRI), we investigated ...
Rigol Montserrat M Department of Cardiology, Institut del Tòrax, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) Hospital Clínic, Universitat de Barcelona, Barcelona, - - 2014
Stem cell therapy offers a promising approach to reduce the long-term mortality rate associated with heart failure after acute myocardial infarction (AMI). To date, in vivo translational studies have not yet fully studied the immune response to allogeneic adipose tissue-derived mesenchymal stem cells (ATMSCs). We analysed the immune response and ...
Morooka Miyako - - 2014
F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising modality for detecting active lesions of cardiac sarcoidosis (CS). However, determining whether 18F-FDG uptake in the myocardium is physiological is challenging due to metabolic shift in myocardial cells. Although methods for inhibiting physiological myocardial 18F-FDG uptake have been proposed, no standard ...
Lyu Ting T Department of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiaotong - - 2014
Animal studies have reported a cardioprotective effect for atrial natriuretic peptide (ANP) or brain natriuretic peptide (BNP) administration in the setting of acute myocardial infarction (AMI). However, previous trials performed on AMI patients have reported differences in the cardiac function protection for ANP/BNP infusion, making it diffi cult to confirm ...
Jarr Kai-Uwe KU Department of Cardiology, Angiology and Pulmonology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120 Heidelberg, - - 2014
Background. TNF-like weak inducer of apoptosis (TWEAK) has recently been shown to be potentially involved in adverse cardiac remodeling. However, neither the exact role of TWEAK itself nor of its receptor Fn14 in this setting is known. Aim of the Study. To analyze the effects of sTWEAK on myocardial function ...
Zhang Juan J 0000-0002-2225-4373 Department of Anesthesiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 1630 Dongfang Road, Shanghai 200127, - - 2014
Early growth response- (Egr-) 1 is an upstream master switch in controlling inflammatory responses following myocardial ischemia-reperfusion (I/R). Activation of extracellular signal-regulated protein kinase-1 and kinase-2 (ERK1/2) signaling is known to upregulate Egr-1. ERK1/2 pathway has been previously shown to mediate the therapeutic action of electroacupucture (EA). Thus, we hypothesized ...
Kondo Takeshi T Department of Cardiology, Takase Clinic, 885-2 Minami-orui, Takasaki 370-0036, - - 2014
Arrhythmias can compromise image quality and increase radiation exposure during coronary CT angiography (CTA). However, premature ventricular contractions (PVCs) can occur in a predictable recurrent and regular pattern (ie, bigeminy, trigeminy, quadrigeminy) with post-PVC compensatory pauses. Electrocardiographic (ECG) electrode repositioning can achieve relative amplification of the R waves of PVCs ...
Feher Attila A Vascular Biology Center, Georgia Health Sciences University, Augusta, GA; Department of Medicine, Weill Cornell Medical College, New York Presbyterian Hospital, New York, - - 2014
The coronary no-reflow phenomenon refers to the post-percutaneous coronary intervention (PCI) state in which, despite successful revascularization of the epicardial conduit coronary arteries, substantial regions of the myocardium do not receive adequate perfusion. In most cases, the underlying mechanism can be attributed to alterations in the microvascular circulation caused by ...
Niu Xiaolin X Department of Cardiology, Tangdu Hospital, the Fourth Military Medical University, Xi'an, Shaanxi, - - 2014
β3-adrenergic receptor (AR) and the downstream signaling, nitric oxide synthase (NOS) isoforms, have been emerged as novel modulators of heart function and even potential therapeutic targets for cardiovascular diseases. However, it is not known whether β3-AR plays cardioprotective effects against myocardial infarction (MI) injury. Therefore, the present study was designed ...
Dias P P National Heart and Lung Institute, Imperial College London Level 4 ICTEM, Hammersmith Campus, DuCane Road, London W12 - - 2014
Cardiac fibrosis is associated with disruptions of the myocardial architecture through changes in volume, composition and organisation of the extracellular matrix. Ivabradine (IVA), a selective inhibitor of the pacemaker current, has shown to have beneficial effects on pathological remodelling. As fibroblasts are the predominant mediators of fibrosis we investigated whether ...
Zhang Wen W Key Laboratory of Cardiovascular Disease and Molecular Intervention, State Key Laboratory of Reproductive Medicine, Atherosclerosis Research Centre, Nanjing Medical University, Nanjing, - - 2014
We tested the hypothesis that direct renin inhibition with aliskiren protects against myocardial ischemia/reperfusion (I/R) injury in spontaneously hypertensive rats (SHR), and examined the mechanism by which this occurs. Male SHR were treated (orally, 4 weeks) with saline or aliskiren (30 or 60 mg kg(-1) day(-1)) and subjected to 30 ...
Nisbet Ashley M AM British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow Glasgow, - - 2014
Acidosis affects the mechanical and electrical activity of mammalian hearts but comparatively little is known about its effects on the function of the atrio-ventricular node (AVN). In this study, the electrical activity of the epicardial surface of the left ventricle of isolated Langendorff-perfused rabbit hearts was examined using optical methods. ...
Bouhidel Jalaleddinne Omar JO Divisions of Molecular Medicine and Cardiology, Departments of Anesthesiology and Medicine, Cardiovascular Research Laboratories, David Geffen School of Medicine at University of California Los Angeles, 650 Charles E. Young Drive, Los Angeles, CA 90095, - - 2014
The present study investigated whether pharmacological postconditoning with netrin-1 is cardioprotective against ischemia reperfusion (I/R) injury, and the underlying signaling mechanisms. Langendorff perfused hearts isolated from wild-type (WT) C57BL/6 or DCC+/- mice underwent a 20-min of ischemia, followed by a 60-min of reperfusion, in the presence or absence of netrin-1, ...
Okunji Priscilla O - - 2014
To evaluate if patient characteristics would have significant effects on outcomes for inpatients' Myocardial Infarction (MI) with Type 2 diabetes (T2D) admitted to Non-Federal Hospitals. We used data from the Healthcare Cost and Utilization Project under the Agency for Healthcare Research and Quality (HCUP_AHRQ, 2006) and data were retrospectively analyzed. ...
Grima Daniel T DT Cornerstone Research Group, Burlington, ON, - - 2014
Ticagrelor demonstrated a significant reduction in major cardiac events in patients with acute coronary syndrome (ACS) compared with clopidogrel in the Platelet Inhibition and Patient Outcomes (PLATO) trial. The objective of this study was to assess the cost-effectiveness of ticagrelor compared with clopidogrel in ACS patients from the perspective of ...
Bencsik Péter P Cardiovascular Research Group, Department of Biochemistry; Pharmahungary Group, Szeged, - - 2013
Pharmacological inhibition of matrix metalloproteinase-2 (MMP-2) is a promising target for acute cardioprotection against ischemia/reperfusion injury. Therefore, here we investigated if the MMP inhibitor ilomastat administered either before ischemia or before reperfusion is able to reduce infarct size via inhibition of MMP-2, the most abundant MMP in the rat heart. ...
Borisenko Oleg O aSynergus AB, Stockholm, Sweden bDepartment of Nephrology, Kuratorium for Dialysis and Transplantation (KfH), Hospital St Georg, Leipzig, Leipzig, Germany cCVRx Inc., Minneapolis, Minnesota, USA dDepartment of Internal Medicine II, Paracelsus Medical University Salzburg, Salzburg, Austria eSynergus AB and Department of Learning, Informatics, Management and Ethics, Karolinska Institutet, Stockholm, - - 2013
The purpose of this study is to simulate the cost-effectiveness and the long-term clinical performance of the Barostim neo System for the treatment of resistant hypertension when compared to optimal medical treatment. A decision analytic model with a combination of a decision tree and Markov process was used to evaluate ...
Shiomi Mayumi M Department of Anesthesiology, Osaka Medical College, Osaka, - - 2013
Sevoflurane preconditioning against myocardial ischemia-reperfusion injury is lost if the ischemic insult is too long. Emerging evidence suggests that induction of autophagy may also confer cardioprotection against ischemia-reperfusion injury. We examined whether induction of autophagy prolongs sevoflurane preconditioning protection during a longer ischemic insult. Isolated guinea pigs hearts were subjected ...
Liu Licette C Y LC Department of Cardiology, University of Groningen, Groningen, The - - 2014
Evidence-based treatment has succeeded in improving clinical outcomes in heart failure. Nevertheless, morbidity, mortality, and the economic burden associated with the syndrome remain unsatisfactorily high. Most landmark heart failure studies included broad study populations, and thus current recommendations dictate standardized, universal therapy. While most patients included in recent trials benefit ...
Ito Yasuhiko Y Nephrology and Renal Replacement Therapy, Nagoya University, Nagoya, - - 2013
ESRD treated with dialysis is associated with increased left ventricular hypertrophy, which, in turn, is related to high mortality. Mineralocorticoid receptor antagonists improve survival in patients with chronic heart failure; however, the effects in patients undergoing dialysis remain uncertain. We conducted a multicenter, open-label, prospective, randomized trial with 158 patients ...
Marchetti Carlo C 1 VCU Pauley Heart Center, 2 Victoria Johnson Research laboratories, 3 Department of Medicinal Chemistry, 4 Department of Pharmacotherapy and Outcome Studies, Virginia Commonwealth University, Richmond, VA, USA 5Department of Systems Medicine, University of Rome Tor Vergata, Rome, - - 2013
The formation of the NLRP3 inflammasome in the heart during AMI amplifies the inflammatory response and mediates further damage. Glyburide has NLRP3-inhibitory activity in vitro, but requires very high doses in vivo, associated with hypoglycemia. The aim of this study was to measure the effects on the NLRP3 inflammasome of ...
Wang Zhen Z Department of Cardiology, Zhongshan Hospital, Shanghai, People's Republic of - - 2014
Coronary heart disease (CHD) is the leading cause of death worldwide. The efficacy and safety of statins in primary and secondary prevention of CHD is confirmed in several large studies, and rosuvastatin is the latest statin on market. We review the published literature on rosuvastatin in Chinese people. The pharmacokinetics ...
Zhu Jianbing - - 2013
We assessed the effects of upstream administration of the glycoprotein IIb/IIIa inhibitor tirofiban before percutaneous coronary intervention (PCI) on spontaneous reperfusion (SR) of infarct-related artery (IRA) and the clinical outcomes in patients with ST-segment elevation myocardial infarction (STEMI). The incidence of SR of the IRA was significantly higher in the ...
Gassanov Natig - - 2013
There is currently no effective prophylactic regimen available to prevent contrast-induced AKI (CI-AKI), a frequent and life-threatening complication after cardiac catheterization. Therefore, novel treatment strategies are required to decrease CI-AKI incidence and to improve clinical outcomes in these patients. Remote ischemic preconditioning (rIPC), defined as transient brief episodes of ischemia ...
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