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Loukas Marios M Department of Anatomical Sciences, St. George's University, Grenada, West Indies; Department of Anatomy, Varmia and Mazuria University School of Medicine, Olsztyn, Poland. Electronic address: - - 2014
Myocardial bridging is a common anatomic variation of the human heart in which an epicardial coronary artery takes an intramural course within the myocardium. Studies have proposed that myocardial bridges offer a "protective effect" from atherosclerosis within the involved coronary artery. We examined 250 formalin-fixed human hearts with gross dissection ...
Waeber Christian C Department of Pharmacology and Therapeutics, School of Medicine, School of Pharmacy, University College - - 2014
This review focuses on the role of sphingosine-1-phosphate (S1P) signaling in the heart, with particular emphasis on how it could be modulated therapeutically in the context of myocardial infarction (MI). After a brief general description of sphingolipid metabolism and signaling, this review will examine the relationship between S1P and the ...
Baker Anthony J AJ Veterans Affairs Medical Center, San Francisco and Department of Medicine, University of California, Cardiology Division (111C), 4150 Clement St, San Francisco, CA, 94121, USA, - - 2014
Heart failure with reduced ejection fraction involves activation of the sympathetic nervous system and chronic hyperactivation of the sympatho-adrenergic receptors (ARs) β-ARs and α1-ARs, which are thought to be cardiotoxic and worsen pathological remodeling and function. Concurrently, the failing heart manifests significant decreases in sympathetic nerve terminal density, decreased cardiac ...
Pelletier Jean-Sébastien JS 1Department of Surgery and 2Department of Pediatrics, University of - - 2014
Vasopressin is an essential hormone involved in the maintenance of cardiovascular homeostasis. It has been in use therapeutically for many decades, with an emphasis on its vasoconstrictive and antidiuretic properties. This hormone has a ubiquitous influence however, and has specific effects on the heart. While difficult to separate from its ...
Sabouret Pierre P Cardiovascular Prevention Institute, 14 bis, boulevard de l'Hôpital, 75005 Paris, France. Electronic address: - - 2014
Effective antagonism of the P2Y12 platelet receptor is central to the treatment of acute coronary syndrome (ACS) patients, especially in the setting of percutaneous coronary intervention and stenting. According to consensus guidelines, early revascularization and intensive antiplatelet therapy are key to reducing the complications that arise from myocardial ischaemia and ...
Rosa Gian Marco GM Clinic of Cardiovascular Diseases, Department of Internal Medicine, University of Genoa School of Medicine. IRCCS Azienda Ospedaliera Universitaria San Martino-IST Istituto Nazionale per la Ricerca sul Cancro, 6 viale Benedetto XV, 16132, Genoa, - - 2014
The natural history of atherosclerosis might involve coronary plaque rupture/erosion, thrombus formation and vessel lumen occlusion, clinically recognized as acute coronary syndrome (ACS). International guidelines strongly recommend early statin administration in patients admitted for ACS. In addition to lowering circulating levels of low-density lipoprotein cholesterol (LDL-c), statin treatment was shown ...
Wu Qin Q Department of Ophthalmology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, - - 2014
Endoplasmic reticulum stress (ERS) can initiate inflammation, and the coupling of these responses is thought to be fundamental to the pathogenesis of cardiovascular disease. However, the mechanism linking ERS and inflammation in myocardial ischemia/reperfusion needs further investigation. Cultured cardiomyocytes were pretreated with SP600125 or salubrinal, followed by tunicamycin to clarify ...
Yoon Alyssa H AH 1Department of Medicine, Baylor College of Medicine, Houston, TX, - - 2014
Diabetes mellitus is a major risk factor for cardiovascular events and patient death. Many animal and clinical studies are now being conducted exploring the potential of antidiabetic drugs such as glucagon-like peptide 1 (GLP-1) agonists and dipeptidyl peptidase IV (DPP-IV) inhibitors to improve cardiovascular outcomes. This review summarizes the effect ...
Grandi Sonia M SM Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada; Division of Clinical Epidemiology, Lady Davis Institute for Medical Research of the Jewish General Hospital, Montreal, QC, - - 2014
Current guidelines recommend smoking cessation and weight management for secondary prevention in post-myocardial infarction patients. However, little is known about the effects of smoking cessation on weight change post-myocardial infarction. We examined patterns of weight change and its effects on blood pressure and glycemic control using data from a randomized ...
Sachdeva Jaspreet J 1The Heart Institute of Good Samaritan Hospital, and Division of Cardiovascular Medicine of the Keck School of Medicine, University of Southern California, Los Angeles, CA, - - 2014
Although preconditioning remains one of the most powerful maneuvers to reduce myocardial infarct size, it is not feasible in the clinical setting to pretreat patients prior to acute myocardial infarction (MI). The purpose of this study was to investigate the effect of more clinically relevant therapies of remote perconditioning, postconditioning, ...
Hamabe Lina L Department of Veterinary Surgery, Tokyo University of Agriculture and Technology, - - 2014
Pimobendan and SCH00013 are calcium sensitizers that possess dual action of calcium sensitization and phosphodiesterase-III inhibition. This study was conducted to comparatively evaluate the effect of these medications on the myocardial function of the canine pacing-induced heart failure model using echocardiography. Heart failure was induced in 20 dogs, to which ...
Díez Javier J School of Medicine, University of Navarra, Pamplona, Spain, - - 2014
Acute heart failure (AHF) is characterized by high morbidity and mortality and high costs. Although the treatment of AHF has not changed substantially in recent decades, it is becoming clear that treatment strategies for AHF need to address both the immediate hemodynamic abnormalities giving rise to congestion as well as ...
Zahida Mamou M EA 4612, Laboratory of Medical Pharmacology, Claude Bernard University, Lyon, - - 2014
The aim of the present study was to determine whether amlodipine and/or perindoprilate injected intravenously (iv) prior to ischemia exerted protective effects on mitochondria structural and functional alterations induced by ischemia and aggravated by reperfusion. Heart rate, the duration of monophasic action potentials (dMAP), peak of the time derivative of ...
Tan Fang F Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, No. 37, Guoxue Road, Chengdu, Sichuan 610041, China. Electronic address: - - 2014
The aim of this study was to explore the expression of sulfonylurea receptor 1 (SUR1), the regulatory subunit of the NCCa-ATP channel, and to investigate the protective effects of gliclazide following middle cerebral artery occlusion (MCAO)/reperfusion in male Wistar rats. Adult rats underwent 2h of the left MCAO using the ...
Cui Kaijun K Department of Cardiovascular Medicine, West China Hospital, Sichuan University, Sichuan 610041, P.R. - - 2014
Basic fibroblast growth factor (bFGF) and platelet-derived growth factor (PDGF) have been shown to be involved in a spectrum of cellular processes. In a previous study, we constructed a novel multigenic vector that contained two separate transcription units, each consisting of a strong promoter and an efficient polyadenylation signal. The ...
Ornek E E Department of Cardiology, Ankara Numune Training and Research Hospital, Ankara, - - 2014
Purpose: We aimed to determine the effect of intravenous thrombolytic therapy on QT dispersion (QTd) and its role in the prediction of reperfusion arrhythmias. Materials and Methods: Twenty patients with acute myocardial infarction (MI) were enrolled in the study. Measurements of QTd were carried out prior to thrombolytic therapy and ...
Zheng Xudong - - 2014
Three-dimensional numerical simulations are employed to investigate hemodynamic effects of abnormal E/A ratios on left ventricular filling. The simulations are performed in a simplified geometric model of the left ventricle in conjunction with a specified endocardial motion. The model has been carefully designed to match important geometric and flow parameters ...
Lønborg Jacob J Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, - - 2014
Hyperglycemia upon admission in ST-segment elevation myocardial infarction (STEMI) patients occurs frequently and is associated with adverse outcome. It is however unsettled whether elevated blood glucose is the cause or consequence of increased myocardial damage. In addition, whether the cardioprotective effect of exenatide, a glucose-lowering drug, is dependent on hyperglycemia ...
Li Ruogu - - 2014
Background and purpose: Coronary chronic total occlusion (CTO) is the last stage of coronary artery atherosclerosis. Percutaneous coronary intervention (PCI) is a therapeutic procedure used to recanalize vessels with total occlusion. However, successful recanalization of CTO is still not optimal, and the key influence factors are still uncertainty. Therefore, a ...
Karantalis Vasileios V University of Miami Miller School of - - 2014
While accumulating data support the efficacy of intramyocardial cell-based therapy to improve LV function in patients with chronic ischemic cardiomyopathy undergoing CABG, the underlying mechanism and impact of cell injection site remain controversial. Mesenchymal stem cells (MSCs) improve LV structure and function through several effects including: reducing fibrosis, neoangiogenesis and ...
Peck Kah Yong KY Department of Clinical Pharmacology, Alfred Hospital, Melbourne, - - 2014
Patients with left ventricular systolic dysfunction (LVSD) are at high risk of sudden cardiac death (SCD). Implantable cardioverter defibrillators (ICDs) have an important role in preventing SCD in selected patients with LVSD and chronic heart failure (CHF). Drug therapies for LVSD and CHF also appear to also be useful in ...
Pena-Philippides Juan Carlos JC Department of Neurosugery, University of New Mexico Health Sciences Center, 1101 Yale Blvd, Albuquerque, NM, 87106-3834, - - 2014
Pulsed electromagnetic fields (PEMF) have been demonstrated to have anti-inflammatory and pro-regenerative effects in animals and humans. We used the FDA-approved Sofpulse™ (Ivivi Health Sciences, LLC) to study effect of PEMF on infarct size and poststroke inflammation following distal middle cerebral artery occlusion (dMCAO) in mice. Electromagnetic field was applied ...
Kolanowski T J TJ Institute of Human Genetics, Polish Academy of Sciences, Poznan, - - 2014
Previously, connexin 43-modified skeletal myoblasts (MbCx) were shown to reduce the pro-arrhythmic effect during the regeneration of heart tissue in an animal model of infarction. To increase the relevance to clinical implementation, in this study, we introduced connexin 43 into human myoblasts using a highly safe non-viral vector and demonstrated ...
Kazi Dhruv S - - 2014
The choice of antiplatelet therapy after acute coronary syndrome (ACS) is complicated: Ticagrelor and prasugrel are novel alternatives to clopidogrel, patients with some genotypes may not respond to clopidogrel, and low-cost generic formulations of clopidogrel are available. To determine the most cost-effective strategy for dual antiplatelet therapy after percutaneous coronary ...
Yeung Eric E Walter Reed National Military Medical Center, Bethesda, - - 2014
Premature ventricular complexes (PVCs) and ventricular tachycardia (VT) are associated with persistent symptoms and ventricular dysfunction. Approved medical therapies have undesirable side effects and proarrhythmic liability. Ranolazine is a novel antianginal that preferentially blocks the late sodium current. This current is enhanced among patients with cardiomyopathy; a promising target population ...
Davies Simon S Heath Services Research Unit, Institute for Science and Technology in Medicine, Keele University, Staffordshire, - - 2014
The ability of peritoneal dialysis (PD) to achieve low-molecular weight solute clearance and ultrafiltration at low haemodynamic cost makes it an attractive therapy in situations where more aggressive therapy may be undesirable due to sudden reductions in cerebral, coronary or renal blood flow. We undertook a review of the literature ...
Mikhail Nasser N Endocrinology Division, OliveView-UCLA Medical Center, David-Geffen School of Medicine, 14445 Olive View Dr, Sylmar, 91342, CA, USA, - - 2014
Studies designed to evaluate the short-term effects of incretin-related drugs in subjects with cardiac disease are still preliminary. In patients with heart failure, two of five studies showed that glucagon-like peptide-1 (GLP-1) infusion was associated with an absolute increase in left ventricular ejection fraction (LVEF) by 6-10 %, whereas no significant ...
Reif Sebastian S Department of Cardiology, Städtisches Klinikum München-Bogenhausen, Munich, - - 2014
Jiménez-Cancil et al. present their results on "Morphology of Far-Field Electrograms and Antitachycardia Pacing Effectiveness Among Fast Ventricular Tachycardias Occurring in ICD Patients: A Multicenter Study". This article is protected by copyright. All rights reserved.
Smith Triston B TB Divisions of Cardiology (Drs. Lasorda, Poornima, Smith, and Staub) and Internal Medicine (Dr. Natarajan), Allegheny General Hospital, Pittsburgh, Pennsylvania - - 2014
We describe the case of a previously healthy 22-year-old man who presented with anginal chest pain and was diagnosed with a non-ST-elevation myocardial infarction. For 3 weeks, he had been ingesting the dietary supplements Jack3d® (principal ingredient, 1,3-dimethylamylamine) and Phenorex™ (principal ingredient, Citrus aurantium) daily, before undertaking physical activity. Coronary ...
Giglio Ada F AF aInstitute of Cardiology, Catholic University of the Sacred Heart, Rome, Italy bStanford University School of Medicine, Stanford, California, USA cTexas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, Texas, USA dUniversity of Foggia, Foggia, - - 2014
Dabigatran is a direct, competitive inhibitor of thrombin recently approved for the prophylaxis of stroke and systemic embolism in patients with nonvalvular atrial fibrillation. In some of the clinical trials evaluating the efficacy and safety of dabigatran in different clinical settings [i.e., prevention of venous thromboembolism (VTE) after orthopedic surgery, ...
Quinones Philip Andrew - - 2014
Reduction of long term mortality by marital status is well established in general populations. However, effects have been shown to change over time and differ considerably by cause of death. This study examined the effects of marital status on long term mortality after the first acute myocardial infarction. Data were ...
Moschetti Karine - - 2014
According to recent guidelines, patients with coronary artery disease (CAD) should undergo revascularization if significant myocardial ischemia is present. Both, cardiovascular magnetic resonance (CMR) and fractional flow reserve (FFR) allow for a reliable ischemia assessment and in combination with anatomical information provided by invasive coronary angiography (CXA), such a work-up ...
Böhm Michael M Klinik für Innere Medizin III, Universitätsklinikum des Saarlandes, DE-66424, Homburg, - - 2014
Comorbidities are frequent in heart failure and impact outcomes. It is not known whether comorbidities are associated with outcomes in asymptomatic left ventricular dysfunction compared to clinical heart failure and whether comorbidities interfere with treatment effects. Our objective was to assess comorbidities and their effects on outcomes in predominantly asymptomatic ...
Joukar Siyavash S Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran, - - 2014
This study assessed the effects of mumie (shilajit) pre-treatment, a traditional drug which is well known in the ancient medicine of both east and west, on cardiac performance of rats subjected to myocardial injury. Animals were divided into control, M250, and M500 (received mumie at dosages of 250 and 500 mg/kg/day, ...
Pong Terrence T Cardiovascular Research Center, Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America ; School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, United States of America ; Harvard-MIT Division of Health Sciences & Technology, Cambridge, Massachusetts, United States of - - 2014
Myocardial infarction resulting from ischemia-reperfusion injury can be reduced by cardiac postconditioning, in which blood flow is restored intermittently prior to full reperfusion. Although key molecular mechanisms and prosurvival pathways involved in postconditioning have been identified, a direct role for eNOS-derived NO in improving regional myocardial perfusion has not been ...
Samoš Matej M Department of Internal Medicine I, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak Republic. Electronic address: - - 2014
Stent thrombosis is a morbid complication after percutaneous coronary intervention. Dual antiplatelet therapy significantly reduces stent thrombosis risk and forms currently the basis in acute ST elevation myocardial infarction pharmacologic treatment. The introduction of clopidogrel has made a major advance in the acute coronary syndrome treatment. However, there is growing ...
Muller Matthew D MD Penn State Hershey Heart and Vascular - - 2014
Forehead cooling activates the sympathetic nervous system and can trigger angina pectoris in susceptible individuals. However, the effect of forehead cooling on coronary blood flow velocity (CBV) is not well understood. In this human experiment, we tested the hypotheses 1) that forehead cooling reduces CBV (i.e., coronary vasoconstriction); and 2) ...
Pavo Noemi N Department of Cardiology, Medical University of Vienna, - - 2014
The quantity of cells with paracrine effects for use in myocardial regeneration therapy is limited. This study investigated the effects of catheter-based endomyocardial delivery of secretome of 2.5 × 10(9) apoptotic peripheral blood mononuclear cells (APOSEC) on porcine chronic post-myocardial infarction (MI) left ventricular (LV) dysfunction and on gene expression. Closed-chest reperfused ...
Cardoso Luis L Department of Biomedical Engineering, The City College of The City University of New York, New York, USA; The Graduate Center of The City University of New York, New York, NY, - - 2014
Approximately half of all cardiovascular deaths associated with acute coronary syndrome occur when the thin fibrous cap tissue overlying the necrotic core in a coronary vessel is torn, ripped or fissured under the action of high blood pressure. From a biomechanics point of view, the rupture of an atheroma is ...
Dai Wangde W 1The Heart Institute, Good Samaritan Hospital, and Division of Cardiovascular Medicine of the Keck School of Medicine, University of Southern California, Los Angeles, CA, USA Guest editor was Dr. Michael - - 2014
Although numerous studies demonstrated that localized delivery of either cells or biomaterials improved postinfarction cardiac function, the underlying mechanisms for this effect remain unclear. We performed a comparison of the effects of fetal, neonatal, and human embryonic stem cell-derived cardiac cell as well as mesenchymal stem cell transplantation versus biomaterial ...
Krenn Lisa L Department of Cardiology, WahringerGürtel 18-20, A-1090 Vienna, - - 2014
Objectives. Cost-effectiveness of percutaneous coronary intervention (PCI) using drug-eluting stents (DES) and coronary artery bypass surgery (CABG) was analysed in patients with multivessel coronary artery disease over a 5-year follow-up. Background. DES implantation reducing revascularization rate and associated costs might be attractive for health economics compared to CABG. Methods. Consecutive ...
Andrukhova Olena O Biomedical Sciences, University of Veterinary Medicine, Vienna, - - 2014
Heart failure (HF) is a common and often fatal complication of myocardial infarction (MI). Glutathione S-transferase P1-1 (GSTP1) has anti-apoptotic, anti-inflammatory effects and is a specific serum marker in HF patients. However, its role in HF treatment is unknown. GSTP1 effect was examined in rat MI-induced HF model. Magnetic resonance ...
Jiang Jiangtao J Key Laboratory of Xinjiang Endemic Phytomedicine Resources, Ministry of Education, School of Pharmacy, Shihezi University, Beierlu, Shihezi, 832002, Xinjiang, - - 2014
This study evaluates antioxidative and cardioprotective effects of total flavonoids extracted from Dracocephalum moldavica L. (DML). The total flavonoids showed remarkable scavenging effects against 1,1-diphenyl-2-picrylhydrazyl, hydroxyl and superoxide anion radicals in vitro. Compared with the ischemia/reperfusion (I/R) group as demonstrated by the use of improved Langendorff retrograde perfusion technology, the total ...
Toeg Hadi Daood HD aDivision of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada bDivision of Cardiac Surgery, Harvard University, Massachusetts General Hospital, Boston, Massachusetts, - - 2014
This article aims to review contemporary studies that utilized mechanical circulatory support (MCS) in the treatment of heart failure and to elaborate on prospective mechanical alternatives. There is a growing need for a well-tolerated, durable and effective MCS option in patients with refractory heart failure. In previous years, the primary ...
De Gennaro Luisa - - 2014
Statins are effective in the prevention of coronary events and the treatment of acute coronary syndromes. However, their efficacy and safety in patients with heart failure (HF) is still a matter of debate. On the basis of literature evidence from subgroup analysis, retrospective, prospective cohort studies, and randomized controlled trials, ...
Rigol Montserrat M Department of Cardiology, Institut del Tòrax, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) Hospital Clínic, Universitat de Barcelona, Barcelona, - - 2014
Stem cell therapy offers a promising approach to reduce the long-term mortality rate associated with heart failure after acute myocardial infarction (AMI). To date, in vivo translational studies have not yet fully studied the immune response to allogeneic adipose tissue-derived mesenchymal stem cells (ATMSCs). We analysed the immune response and ...
Bouhidel Jalaleddinne Omar JO Divisions of Molecular Medicine and Cardiology, Departments of Anesthesiology and Medicine, Cardiovascular Research Laboratories, David Geffen School of Medicine at University of California Los Angeles, 650 Charles E. Young Drive, Los Angeles, CA 90095, - - 2014
The present study investigated whether pharmacological postconditoning with netrin-1 is cardioprotective against ischemia reperfusion (I/R) injury, and the underlying signaling mechanisms. Langendorff perfused hearts isolated from wild-type (WT) C57BL/6 or DCC+/- mice underwent a 20-min of ischemia, followed by a 60-min of reperfusion, in the presence or absence of netrin-1, ...
Morooka Miyako - - 2014
F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising modality for detecting active lesions of cardiac sarcoidosis (CS). However, determining whether 18F-FDG uptake in the myocardium is physiological is challenging due to metabolic shift in myocardial cells. Although methods for inhibiting physiological myocardial 18F-FDG uptake have been proposed, no standard ...
Grima Daniel T DT Cornerstone Research Group, Burlington, ON, - - 2014
Ticagrelor demonstrated a significant reduction in major cardiac events in patients with acute coronary syndrome (ACS) compared with clopidogrel in the Platelet Inhibition and Patient Outcomes (PLATO) trial. The objective of this study was to assess the cost-effectiveness of ticagrelor compared with clopidogrel in ACS patients from the perspective of ...
Maslov Leonid N LN The Laboratory of Experimental Cardiology, Research Institute of Cardiology, Siberian Branch, Russian Academy of Medical Sciences, Tomsk, - - 2014
The objective of this study was to investigate the role of peripheral μ, δ1, δ2, and nociceptin opioid receptors agonists in the regulation of cardiac tolerance to the arrhythmogenic effect of ischemia/reperfusion in rats. Anesthetized open-chest male Wistar rats were subjected to either 45 minutes of left coronary artery occlusion (phase ...
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