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Lee Lik Chuan LC Departments of Surgery, University of California, San Francisco, CA, - - 2014
The Parachute(®) (Cardiokinetix, Inc., Menlo Park, California) is a catheter-based device intended to reverse left ventricular (LV) remodeling after antero-apical myocardial infarction. When deployed, the device partitions the LV into upper and lower chambers. To simulate its mechanical effects, we created a finite element LV model based on computed tomography ...
Sohinki Daniel D Division of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9047, USA. Electronic address: - - 2014
Permanent cardiac pacemakers (PPM) are effective in the treatment of bradycardia in a growing number of clinical scenarios. An appreciation of the capacity of PPMs to result in negative hemodynamic and proarrhythmic effects has grown alongside clinical experience with permanent pacing. Such experience has necessitated the development of algorithms aimed ...
Park Sang-Don - - 2014
Although prompt reperfusion treatment restores normal epicardial flow, microvascular dysfunction may persist in some patients with acute coronary syndrome (ACS). Impaired myocardial perfusion is caused by intraluminal platelets, fibrin thrombi and neutrophil plugging; antiplatelet agents play a significant role in terms of protecting against thrombus microembolization. A novel antiplatelet agent, ...
Sossalla Samuel S Klinik für Kardiologie und Pneumologie / Herzzentrum, Georg-August-Universität Göttingen; DZHK (German Center for Cardiovascular - - 2014
Torsades de pointes (TdP) tachycardias are triggered, polymorphic ventricular arrhythmias arising from early afterdepolarizations (EAD) and increased dispersion of repolarization. Ranolazine is a new agent which reduces pathologically elevated late IN a but also IK r . Aim of this study was to evaluate the effects of ranolazine in a ...
Spinale Francis G FG Cardiovascular Translational Research Center, University of South Carolina School of Medicine; Department of Cell Biology and Anatomy, University of South Carolina School of Medicine; WJB Dorn Veteran Affairs Medical Center, Columbia, South Carolina. Electronic address: - - 2014
Basic pharmacological/transgenic studies have clearly demonstrated a cause-effect relationship between the induction and activation of matrix metalloproteinases (MMPs) and adverse changes in the structure and function of the left ventricle (LV). Thus, regulation of MMP induction and/or activation would appear to be a potential therapeutic target in the context of ...
Maceira Alicia M - - 2014
Cocaine is an addictive, sympathomimetic drug with potentially lethal effects. The prevalence and features of cocaine cardiotoxicity are not well known. We aimed to assess these effects using a comprehensive cardiovascular magnetic resonance (CMR) protocol in a large group of asymptomatic cocaine users. Consecutive (n = 94, 81 males, 36.6 ...
Ramirez Trevi A TA San Antonio Cardiovascular Proteomics Center and Mississippi Center for Heart Research, Department of Biophysics and Physiology, University of Mississippi Medical Center, Jackson, - - 2014
We evaluated whether aliskiren, valsartan, or the combination was protective following myocardial infarction (MI) through effects on matrix metalloproteinase (MMP)-9. C57BL/6J wild type (WT, n=94) and MMP-9 null (null, n=85) mice were divided into 4 groups at 3h post-MI: saline (S), aliskiren (A; 50mg/kg/d), valsartan (V; 40mg/kg/d), or A+V and ...
Asrar Ul Haq Muhammad M Department of Cardiology, The Northern Hospital, Melbourne, - - 2014
Arterial thrombosis in acute coronary syndrome (ACS) is associated with activation of platelets and the coagulation cascade. Persistent thrombin levels have been reported after ACS in such patients. Novel oral anticoagulants without a need of close monitoring and frequent blood tests such as warfarin can provide a chronic beneficial effect ...
Smith Alison A Primary Care Mental Health, Health Services and Population Research Dept, Institute of Psychiatry, Kings College London, De Crespigny Park, London SE5 8AF, - - 2014
Patients can report positive effects of myocardial infarction. It is unknown whether these effects are sustained or what factors influence adaptation. To explore primary care patients' perceptions of the effect of coronary heart disease and to identify possible modifiable predictors of adaptation. Cross-sectional, sub-study of UPBEAT cohort participants. Patients were ...
Jones Huw Bowen HB 1Pathological Sciences, Global Safety Assessment, AstraZeneca Pharmaceuticals, Alderley Park, Macclesfield, - - 2014
Pharmaceutical therapies for non-insulin-dependent diabetes mellitus (NIDDM) include plasma glucose lowering by enhancing glucose utilization. The mitochondrial pyruvate dehydrogenase (PDH) complex is important in controlling the balance between glucose and fatty acid substrate oxidation. Administration of pyruvate dehydrogenase kinase inhibitors (PDHKIs) to rats effectively lowers plasma glucose but results in ...
Conway Aaron A 1 School of Nursing, Queensland University Technology , Kelvin Grove, Queensland, Australia - - 2014
Abstract Background: Trials of new technologies to remotely monitor for signs and symptoms of worsening heart failure are continually emerging. The extent to which technological differences impact the effectiveness of noninvasive remote monitoring for heart failure management is unknown. This study examined the effect of specific technology used for noninvasive ...
Al Mamun Mohammad M Department of Public Health, General Directorate of Health Affairs in Tabuk Region, Ministry of Health, P.O. Box No. 16673, Tabuk 71474, Kingdom of Saudi Arabia. Electronic address: - - 2014
Detailed research initiatives are required to get a clear scenario on complete characterization of environmental triggers in relation to conventional cardiovascular risk factors.
Iqbal Javaid J Department of Cardiovascular Science at the University of Sheffield, and Cardiology Department at Sheffield Teaching Hospitals NHS Trust, Sheffield, - - 2014
EPHESUS was a multicentre, double-blind clinical trial in which 6632 patients with acute myocardial infarction (AMI) complicated by LV systolic dysfunction (LVSD) were randomized to receive eplerenone (n = 3319) or placebo (n = 3313). A total of 1580 EPHESUS patients were treated with PCI, which is now the standard ...
Sato Shinsuke S Department of Neurosurgery, Tokyo Women's Medical University, Tokyo, - - 2014
The sigma-1 receptor has been reported to be associated with diverse biological activities including cellular differentiation, neuroplasticity, neuroprotection, and cognitive functioning of the brain. Fluvoxamine, one of the currently known antidepressants, is a sigma-1 receptor agonist; its effectiveness in treating acute cerebral ischemia has not been reported. We studied the ...
De Silva Kalpa K King's College London British Heart Foundation Centre of Excellence, National Institute for Health Research Biomedical Research Centre at Guy's and St. Thomas's National Health Service Foundation Trust, Cardiovascular Division, The Rayne Institute, London, United - - 2014
This study sought to identify the effect of coronary autoregulation on myocardial perfusion during intra-aortic balloon pump (IABP) therapy. IABP is the most commonly used circulatory support device, although its efficacy in certain scenarios has been questioned. The impact of alterations in microvascular function on IABP efficacy has not previously ...
Romaszko Pawel P a Department of Biochemistry , Medical University of Gdansk , Gdansk , - - 2014
We recently described a new nicotinamide derivative: 4-pyridone-3-carboxamide ribonucleoside (4PYR) and its conversion to intracellular metabolites (4PYR monophosphate: 4PYMP and 4PYR adenylate diphosphate: 4PYRAD). The aim of this study was to clarify the metabolism and physiological effects of brief exposure to 4PYR in perfused rat heart. Rat hearts were perfused ...
Asanuma Hiroshi H 1] Department of Cardiovascular Science and Technology, Kyoto Prefectural University School of Medicine, Kyoto, Japan [2] Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, - - 2014
Carperitide is effective for heart failure (HF) owing to its diuretic and vasodilatory effects. This recombinant peptide may also have direct cardioprotective effects because carperitide reduces the severity of heart failure and limits infarct size. Because coronary vasodilation is an important cardioprotective treatment modality, we investigated whether carperitide increased coronary ...
Akturk I F IF Department of Cardiology, Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery, Training and Research Hospital, Istanbul, Turkey - - - 2014
We aimed to investigate the effects of verapamil and adenosine in an adjunct to intravenous tirofiban on management and prognosis of noreflow phenomenon during primary percutaneous coronary intervention (PPCI) and to compare their efficacies on reversing of noreflow phenomenon and short and midterm survival. We included 46 patients with acute ...
Wang Qian Q Tissue Mechanics Laboratory, Biomedical Engineering Department, Georgia Institute of Technology, Atlanta, GA 30313, United - - 2014
This study was to investigate the mechanisms of ischemic mitral regurgitation (IMR) by using a finite element (FE) approach. IMR is a common complication of coronary artery disease; and it usually occurs due to myocardial infarction. The pathophysiological mechanisms of IMR have not been fully understood, much debate remains about ...
Tofield Andros - - 2014
People's perception of the effect of stress on their health is linked to risk of myocardial infarction according to a study.
Maslov L N LN Research Institute of Cardiology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia, - - 2014
Hypoxic preconditioning produces an infarct-limiting effect both in the early and delayed periods. The increase in heart resistance to ischemia-repefusion was more pronounced after early preconditioning. Hypoxic preconditioning did not change heart resistance to the arrhythmogenic effect of coronary occlusion and reperfusion.
Zhernakova N I NI Belgorod State National Research University, Belgorod, - - 2014
Administration of Cytoflavin to young rats with experimental myocardial ischemia was followed by activation of mitochondrial enzymes and significant accumulation of ATP in the myocardium and blood plasma, but did not modulate the stability of cardiomyocyte membranes and signs of hypoxia. Cytoflavin increased the severity of metabolic disorders and depleted ...
Takayama Hiroo H aDivision of Cardiothoracic Surgery bDivision of Cardiology, New York Presbyterian Hospital, Columbia University Medical Center, New York, New York, - - 2014
To provide a comprehensive update on the current state of short-term, continuous-flow ventricular assist devices (CF-VADs) in the treatment of refractory cardiogenic shock in Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) 1 patients. The mortality rate associated with refractory cardiogenic shock remains markedly elevated, with INTERMACS 1 profile repeatedly ...
Purcell Brendan P BP Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, - - 2014
Inhibitors of matrix metalloproteinases (MMPs) have been extensively explored to treat pathologies where excessive MMP activity contributes to adverse tissue remodelling. Although MMP inhibition remains a relevant therapeutic target, MMP inhibitors have not translated to clinical application owing to the dose-limiting side effects following systemic administration of the drugs. Here, ...
Cong Xiaoqiang X Department of Cardiology, Bethune First Hospital of Jilin University, Changchun, Jilin 130021, P.R. - - 2014
The role of resveratrol (Res) in inflammation induced by ischemia/reperfusion is not well understood. The aim of the present study was to investigate whether Res modulates neutrophil accumulation and tumor necrosis factor‑α (TNF‑α) induction in an ischemia/reperfusion‑injured rat heart model. The rats were randomly exposed to sham surgery, myocardial ischemia/reperfusion ...
Kisvári Gábor G Departments of Pharmacology and Pharmacotherapy, University of Szeged, Albert-Szent Györgyi Medical Centre, Szeged, - - 2014
The present study has examined the effects and the possible mechanisms of a single dose of simvastatin on the severity of arrhythmias resulting from a 25min occlusion and reperfusion of the left anterior descending coronary artery in anaesthetized (chloralose and urethane) dogs. The control animals (n=16) were given the solvent ...
Molenaar Peter P Faculty of Health, QUT, Brisbane; School of Medicine, University of Queensland and Critical Care Research Group, The Prince Charles Hospital, Chermside, QLD, 4032, Australia, - - 2014
The β-blockers carvedilol and metoprolol provide important therapeutic strategies for heart failure treatment. Therapy with metoprolol facilitates the control by phosphodiesterase PDE3, but not PDE4, of inotropic effects of catecholamines in human failing ventricle. However, it is not known whether carvedilol has the same effect. We investigated whether the PDE3-selective ...
de Jong Renate R From the Department of Cardiology, Thoraxcenter, Erasmus University Medical Center, Rotterdam, the Netherlands (R.d.J., J.H.H., S.S., E.B.); and Department of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands - - 2014
Several cell-based therapies for adjunctive treatment of acute myocardial infarction have been investigated in multiple clinical trials, but the benefits still remain controversial. This meta-analysis aims to evaluate the efficacy of bone marrow-derived mononuclear cell (BMMNC) therapy in patients with acute myocardial infarction, but also explores the effect of newer ...
López-Olañeta Marina M MM Cardiovascular Development and Repair Dept. - - 2014
Ventricular remodelling following myocardial infarction progressively leads to loss of contractile capacity and heart failure. Although calcineurin promotes maladaptive cardiac hypertrophy, we recently showed that the calcineurin splicing variant CnAβ1 has beneficial effects on the infarcted heart. However, whether this variant limits necrosis or improves remodelling is still unknown, precluding ...
Bergmeijer Thomas O TO Department of Cardiology, St Antonius Hospital, Nieuwegein, The Netherlands. Electronic address: - - 2014
In patients with ST-segment elevation myocardial infarction (STEMI) who undergo primary percutaneous coronary intervention (pPCI), the use of dual antiplatelet therapy is essential to prevent atherothrombotic complications. Therefore, patients are treated with acetylsalicylic acid and clopidogrel, prasugrel, or ticagrelor. Clopidogrel, however, shows a major interindividual variation in antiplatelet effect, which ...
Lee Hui-Ling HL Department of Anesthesia, Chang Gung Memorial Hospital, Taipei, - - 2014
The stability of dynamic factors has been reported to play a role in the antiarrhythmic actions of adenosine triphosphate (ATP)-sensitive potassium channel (KATP ) opener in phase-2 myocardial infarction (MI) hearts. In the situation of the downregulation of KATP , the effects of KATP blocker (HMR1098) on the dynamic factors ...
Akerström Finn F Cardiac Arrhythmia and Electrophysiology Unit, Department of Cardiology, Hospital Virgen de la Salud, Toledo, - - 2014
The permanent cardiac pacemaker is the only effective therapy for patients with symptomatic bradycardia and hundreds of millions are implanted worldwide every year. Despite its undisputed clinical benefits, the last two decades have drawn much attention to the negative effects associated with long-term pacing of the right ventricle (RV). Experimental ...
Loukas Marios M Department of Anatomical Sciences, St. George's University, Grenada, West Indies; Department of Anatomy, Varmia and Mazuria University School of Medicine, Olsztyn, Poland. Electronic address: - - 2014
Myocardial bridging is a common anatomic variation of the human heart in which an epicardial coronary artery takes an intramural course within the myocardium. Studies have proposed that myocardial bridges offer a "protective effect" from atherosclerosis within the involved coronary artery. We examined 250 formalin-fixed human hearts with gross dissection ...
Waeber Christian C Department of Pharmacology and Therapeutics, School of Medicine, School of Pharmacy, University College - - 2014
This review focuses on the role of sphingosine-1-phosphate (S1P) signaling in the heart, with particular emphasis on how it could be modulated therapeutically in the context of myocardial infarction (MI). After a brief general description of sphingolipid metabolism and signaling, this review will examine the relationship between S1P and the ...
Baker Anthony J AJ Veterans Affairs Medical Center, San Francisco and Department of Medicine, University of California, Cardiology Division (111C), 4150 Clement St, San Francisco, CA, 94121, USA, - - 2014
Heart failure with reduced ejection fraction involves activation of the sympathetic nervous system and chronic hyperactivation of the sympatho-adrenergic receptors (ARs) β-ARs and α1-ARs, which are thought to be cardiotoxic and worsen pathological remodeling and function. Concurrently, the failing heart manifests significant decreases in sympathetic nerve terminal density, decreased cardiac ...
Pelletier Jean-Sébastien JS 1Department of Surgery and 2Department of Pediatrics, University of - - 2014
Vasopressin is an essential hormone involved in the maintenance of cardiovascular homeostasis. It has been in use therapeutically for many decades, with an emphasis on its vasoconstrictive and antidiuretic properties. This hormone has a ubiquitous influence however, and has specific effects on the heart. While difficult to separate from its ...
Sabouret Pierre P Cardiovascular Prevention Institute, 14 bis, boulevard de l'Hôpital, 75005 Paris, France. Electronic address: - - 2014
Effective antagonism of the P2Y12 platelet receptor is central to the treatment of acute coronary syndrome (ACS) patients, especially in the setting of percutaneous coronary intervention and stenting. According to consensus guidelines, early revascularization and intensive antiplatelet therapy are key to reducing the complications that arise from myocardial ischaemia and ...
Rosa Gian Marco GM Clinic of Cardiovascular Diseases, Department of Internal Medicine, University of Genoa School of Medicine. IRCCS Azienda Ospedaliera Universitaria San Martino-IST Istituto Nazionale per la Ricerca sul Cancro, 6 viale Benedetto XV, 16132, Genoa, - - 2014
The natural history of atherosclerosis might involve coronary plaque rupture/erosion, thrombus formation and vessel lumen occlusion, clinically recognized as acute coronary syndrome (ACS). International guidelines strongly recommend early statin administration in patients admitted for ACS. In addition to lowering circulating levels of low-density lipoprotein cholesterol (LDL-c), statin treatment was shown ...
Wu Qin Q Department of Ophthalmology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, - - 2014
Endoplasmic reticulum stress (ERS) can initiate inflammation, and the coupling of these responses is thought to be fundamental to the pathogenesis of cardiovascular disease. However, the mechanism linking ERS and inflammation in myocardial ischemia/reperfusion needs further investigation. Cultured cardiomyocytes were pretreated with SP600125 or salubrinal, followed by tunicamycin to clarify ...
Yoon Alyssa H AH 1Department of Medicine, Baylor College of Medicine, Houston, TX, - - 2014
Diabetes mellitus is a major risk factor for cardiovascular events and patient death. Many animal and clinical studies are now being conducted exploring the potential of antidiabetic drugs such as glucagon-like peptide 1 (GLP-1) agonists and dipeptidyl peptidase IV (DPP-IV) inhibitors to improve cardiovascular outcomes. This review summarizes the effect ...
Grandi Sonia M SM Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada; Division of Clinical Epidemiology, Lady Davis Institute for Medical Research of the Jewish General Hospital, Montreal, QC, - - 2014
Current guidelines recommend smoking cessation and weight management for secondary prevention in post-myocardial infarction patients. However, little is known about the effects of smoking cessation on weight change post-myocardial infarction. We examined patterns of weight change and its effects on blood pressure and glycemic control using data from a randomized ...
Sachdeva Jaspreet J 1The Heart Institute of Good Samaritan Hospital, and Division of Cardiovascular Medicine of the Keck School of Medicine, University of Southern California, Los Angeles, CA, - - 2014
Although preconditioning remains one of the most powerful maneuvers to reduce myocardial infarct size, it is not feasible in the clinical setting to pretreat patients prior to acute myocardial infarction (MI). The purpose of this study was to investigate the effect of more clinically relevant therapies of remote perconditioning, postconditioning, ...
Díez Javier J School of Medicine, University of Navarra, Pamplona, Spain, - - 2014
Acute heart failure (AHF) is characterized by high morbidity and mortality and high costs. Although the treatment of AHF has not changed substantially in recent decades, it is becoming clear that treatment strategies for AHF need to address both the immediate hemodynamic abnormalities giving rise to congestion as well as ...
Hamabe Lina L Department of Veterinary Surgery, Tokyo University of Agriculture and Technology, - - 2014
Pimobendan and SCH00013 are calcium sensitizers that possess dual action of calcium sensitization and phosphodiesterase-III inhibition. This study was conducted to comparatively evaluate the effect of these medications on the myocardial function of the canine pacing-induced heart failure model using echocardiography. Heart failure was induced in 20 dogs, to which ...
Zahida Mamou M EA 4612, Laboratory of Medical Pharmacology, Claude Bernard University, Lyon, - - 2014
The aim of the present study was to determine whether amlodipine and/or perindoprilate injected intravenously (iv) prior to ischemia exerted protective effects on mitochondria structural and functional alterations induced by ischemia and aggravated by reperfusion. Heart rate, the duration of monophasic action potentials (dMAP), peak of the time derivative of ...
Tan Fang F Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, No. 37, Guoxue Road, Chengdu, Sichuan 610041, China. Electronic address: - - 2014
The aim of this study was to explore the expression of sulfonylurea receptor 1 (SUR1), the regulatory subunit of the NCCa-ATP channel, and to investigate the protective effects of gliclazide following middle cerebral artery occlusion (MCAO)/reperfusion in male Wistar rats. Adult rats underwent 2h of the left MCAO using the ...
Cui Kaijun K Department of Cardiovascular Medicine, West China Hospital, Sichuan University, Sichuan 610041, P.R. - - 2014
Basic fibroblast growth factor (bFGF) and platelet-derived growth factor (PDGF) have been shown to be involved in a spectrum of cellular processes. In a previous study, we constructed a novel multigenic vector that contained two separate transcription units, each consisting of a strong promoter and an efficient polyadenylation signal. The ...
Ornek E E Department of Cardiology, Ankara Numune Training and Research Hospital, Ankara, - - 2014
Purpose: We aimed to determine the effect of intravenous thrombolytic therapy on QT dispersion (QTd) and its role in the prediction of reperfusion arrhythmias. Materials and Methods: Twenty patients with acute myocardial infarction (MI) were enrolled in the study. Measurements of QTd were carried out prior to thrombolytic therapy and ...
Zheng Xudong - - 2014
Three-dimensional numerical simulations are employed to investigate hemodynamic effects of abnormal E/A ratios on left ventricular filling. The simulations are performed in a simplified geometric model of the left ventricle in conjunction with a specified endocardial motion. The model has been carefully designed to match important geometric and flow parameters ...
Lønborg Jacob J Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, - - 2014
Hyperglycemia upon admission in ST-segment elevation myocardial infarction (STEMI) patients occurs frequently and is associated with adverse outcome. It is however unsettled whether elevated blood glucose is the cause or consequence of increased myocardial damage. In addition, whether the cardioprotective effect of exenatide, a glucose-lowering drug, is dependent on hyperglycemia ...
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