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Oni-Orisan Akinyemi A Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Center for Pharmacogenomics and Individualized Therapy, University of North Carolina at Chapel Hill, Chapel Hill, NC, - - 2014
Cardiovascular disease, including acute myocardial infarction (AMI), is the leading cause of morbidity and mortality globally, despite well-established treatments. The discovery and development of novel therapeutics that prevent the progression of devastating consequences following AMI are thus important in reducing the global burden of this devastating disease. Scientific evidence for ...
Hoogeveen Ellen K EK Department of Internal Medicine and Nephrology, Jeroen Bosch Hospital, Den Bosch, the Netherlands - - 2014
heart failure is a major risk factor for cardiovascular mortality, for which n-3 fatty acids may have beneficial effects. We examined the effect of marine eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and plant-derived alpha-linolenic acid (ALA) on N-Terminal-pro Brain Natriuretic Peptide (NT-proBNP), a biomarker of heart failure. we randomly ...
Kuehn Andreas A Department of Pediatric Cardiology and Congenital Heart Disease, Deutsches Herzzentrum - - 2014
Background:Coronary flow reserve (CFR) is reduced in patients with transposition of the great arteries (TGA) after the arterial switch operation (ASO). Dissection of the great arteries and coronary reimplantation may result in sympathetic denervation, with a negative effect on myocardial perfusion.Methods and Results:18 patients with TGA participated in the study; 9 had ...
Burashnikov Alexander A Masonic Medical Research Laboratory, Utica, - - 2014
-There is a critical need for safer and more effective pharmacological management of atrial fibrillation (AF) in the setting of heart failure (HF). -This study investigates the electrophysiological, anti- and pro-arrhythmic effects of a clinically-relevant concentration of ranolazine (5 µM) in coronary-perfused right atrial and left ventricular preparations isolated from ...
Momiyama Yukihiko Y Department of Cardiology, National Hospital Organization Tokyo Medical Center, 2-5-1 Higashigaoka, Meguro-ku, Tokyo 152-8902, Japan. Electronic address: - - 2014
Apelin is an endogenous ligand for the orphan G protein-coupled receptor (APJ receptor). Apelin is predominantly expressed in endocardial and vascular endothelial cells, while APJ receptor is localized to endothelial and smooth muscle cells, and cardiomyocytes. Apelin has recently attracted much attention due to its promotive effects on angiogenesis and ...
Wei Bo B State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China. Electronic address: - - 2014
The protective effect of sodium tanshinone IIA sulfonate (STS) pretreatment against experimental myocardial ischemia/reperfusion (I/R) has been demonstrated previously, however its therapeutic effects and mechanism of action still remain unclear. The objective of this study was to investigate the therapeutic time window and potential mechanism of STS action on myocardial ...
Schade Anja A Klinik für Kardiologie II (Interventionelle Elektrophysiologie), Herz-und Gefäßklinik Bad Neustadt, Salzburger Leite 1, 97616, Bad Neustadt a.d. Saale, Germany, - - 2014
Catheter ablation is an effective treatment for ventricular tachycardia (VT) in structural heart disease to reduce VT recurrence and implantable cardioverter defibrillator shocks.Current guidelines recommend ablation in patients with recurrent or incessant VT. In patients with left ventricular assist device (LVAD), VTs may be well tolerated hemodynamically and catheter ablation ...
Grossini Elena E E Grossini, Facoltà di Medicina e Chirurgi, Università del Piemonte Orientale, Novara, 28100, Italy - - 2014
Adiponectin, the most abundant adipokine released by adipose tissue, appears to play an important role in the regulation of vascular endothelial and cardiac function. To date however, the physiological effects of human monomeric adiponectin on the coronary vasculature and myocardial systo-diastolic function, as well as on parasympathetic/sympathetic involvement and nitric ...
Zhang Zheng Z Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi`an, 710032, - - 2014
5-Diphosphoinositol pentakisphosphate (IP7), formed by a family of inositol hexakisphosphate kinases (IP6Ks), has been demonstrated to be a physiologic inhibitor of Akt. IP6K inhibition may increase Akt activation in mesenchymal stem cells (MSCs), resulting in enhanced cardiac protective effect after transplantation. The aim of this study was to investigate the ...
Gonca Ersöz E Biology Department, Faculty of Art and Sciences, Bülent Ecevit University, İncivez, Zonguldak, Turkey - - 2014
Cannabidiol (CBD) is a nonpsychoactive phytocannabinoid with anti-inflammatory activity mediated by enhancing adenosine signaling. As the adenosine A1 receptor activation confers protection against ischemia/reperfusion (I/R)-induced ventricular arrhythmias, we hypothesized that CBD may have antiarrhythmic effect through the activation of adenosine A1 receptor. Cannabidiol has recently been shown to suppress ischemia-induced ...
Rognoni Andrea A Coronary Care Unit and Catheterization Laboratory, "Maggiore della Carità" Hospital, Corso Mazzini 18, 28100 Novara, - - 2014
Intra-aortic balloon counterpulsation is the most widely used form of mechanical hemodynamic support in the setting of cardiogenic shock due to ST-segment elevation myocardial infarction (STEMI). Intra-aortic balloon pump (IABP) is also strongly recommended (class 1b) in the current European guidelines for treatment of STEMI. The evidence of a possible ...
Suarez Jorge J University of California, San - - 2014
Ischemic heart disease (IHD) is the single most common cause of death. New approaches to enhance myocardial perfusion are needed to improve outcomes for patients with IHD. Thyroid hormones (TH) are known to increase blood flow; however, their usefulness for increasing perfusion in IHD is limited because TH accelerates heart ...
Ren Yongkui Y Department of Cardiology, The First Affiliated Hospital of China Medical University, 155th North of Nanjing Street, Heping District, Shenyang, 110001, Liaoning Province, - - 2014
KB-R7943 reduces lethal reperfusion injury under normal conditions, but its effectiveness under certain pathological states is in dispute. In the present study, we sought to determine the effect of KB-R7943 in hyperlipidemic animals and assess if the K ATP (+) are involved in the protective mechanisms. In group 1 (G1), ...
Takawale Abhijit A Department of Physiology, University of Alberta, Edmonton, Canada; Mazankowski Alberta Heart Institute, Edmonton, - - 2014
-Myocardial reperfusion following ischemia (I/R), while an effective approach in rescuing the ischemic myocardium, can itself trigger a number of adverse effects including aberrant remodeling of the myocardium and its extracellular matrix (ECM). Tissue inhibitor of metalloproteinases (TIMPs) protect the ECM against excess degradation by matrix metalloproteinases (MMPs). TIMP4 levels ...
Wang Qianmei Q Department of Emergency, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, Shaanxi Province, PR China; Department of Physiology, National Key Discipline of Cell Biology, Fourth Military Medical University, Xi'an 710032, Shaanxi Province, PR - - 2014
To keep U50488H from going through the blood-brain barrier, U50488H, a selective κ-opioid receptor agonist, was structurally transformed to its quaternary ammonium salt (Q-U50488H). The effect of Q-U50488H on ischemic/reperfused myocardium and its underlying mechanisms were also investigated. U50488H was transformed to Q-U50488H, which was identified with mass spectrometry. The ...
Soraya Hamid H Department of Pharmacology, Faculty of Pharmacy, Urmia University of Medical Sciences, Urmia, - - 2014
Acute treatment with metformin has a protective effect in myocardial infarction by suppression of inflammatory responses due to activation of AMP-activated protein kinase (AMPK). In the present study, the effect of chronic pre-treatment with metformin on cardiac dysfunction and toll-like receptor 4 (TLR4) activities following myocardial infarction and their relation ...
Tanaka Motonao M Cardiovascular Center, Tohoku Pharmaceutical University Hospital, Sendai, Japan. Electronic address: - - 2014
We attempted to disclose the microscopic characteristics of the non-uniform distribution of the contraction and extension (C-E) of the left ventricular (LV) myocardium using a new methodology (echo-dynamography). The distributions of the "axial strain rate" (aSR) and the intra-mural velocity in the local areas of the free wall including the ...
Garg Monika M Cardiovascular Pharmacology Division Department of Pharmacology Rajendra Institute of Technology and Sciences - - 2014
High incidences of myocardial infarction associated with high morbidity and mortality, are a major concern and economic burden on industrialized nations. Persistent β-adrenergic receptor stimulation with isoproterenol leads to the development of oxidative stress, myocardial inflammation, thrombosis, platelet aggregation and calcium overload, which ultimately cause myocardial infarction. Therapeutic agents that ...
Layland Jamie J University of Glasgow, Golden Jubilee National Hospital, Glasgow, United - - 2014
Adenosine is a ubiquitous extracellular signaling molecule with essential functions in human physiology. Due to the widespread expression of adenosine receptors, it has far-reaching effects across many different organ systems. With a prominent role in the cardiovascular system, it has been extensively studied for both its therapeutic and diagnostic abilities. ...
Zhang Yu-Lin YL 1] State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College [2] Department of Anesthesiology, Fuwai Cardiovascular Hospital, Beijing 100037, - - 2014
Aim:Sevoflurane postconditioning (SpostC) has been shown to protect the heart from ischemia-reperfusion (I/R) injury. In this study, we examined whether SpostC affected autophagic flux in myocardial tissues that contributed to its cardioprotective effects in rats following acute I/R injury.Methods:SD rats underwent 30 min of left anterior descending coronary artery ligation ...
Lee Lik Chuan LC Departments of Surgery, University of California, San Francisco, CA, - - 2014
The Parachute(®) (Cardiokinetix, Inc., Menlo Park, California) is a catheter-based device intended to reverse left ventricular (LV) remodeling after antero-apical myocardial infarction. When deployed, the device partitions the LV into upper and lower chambers. To simulate its mechanical effects, we created a finite element LV model based on computed tomography ...
Sohinki Daniel D Division of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9047, USA. Electronic address: - - 2014
Permanent cardiac pacemakers (PPM) are effective in the treatment of bradycardia in a growing number of clinical scenarios. An appreciation of the capacity of PPMs to result in negative hemodynamic and proarrhythmic effects has grown alongside clinical experience with permanent pacing. Such experience has necessitated the development of algorithms aimed ...
Park Sang-Don - - 2014
Although prompt reperfusion treatment restores normal epicardial flow, microvascular dysfunction may persist in some patients with acute coronary syndrome (ACS). Impaired myocardial perfusion is caused by intraluminal platelets, fibrin thrombi and neutrophil plugging; antiplatelet agents play a significant role in terms of protecting against thrombus microembolization. A novel antiplatelet agent, ...
Sossalla Samuel S Klinik für Kardiologie und Pneumologie / Herzzentrum, Georg-August-Universität Göttingen; DZHK (German Center for Cardiovascular - - 2014
Torsades de pointes (TdP) tachycardias are triggered, polymorphic ventricular arrhythmias arising from early afterdepolarizations (EAD) and increased dispersion of repolarization. Ranolazine is a new agent which reduces pathologically elevated late IN a but also IK r . Aim of this study was to evaluate the effects of ranolazine in a ...
Spinale Francis G FG Cardiovascular Translational Research Center, University of South Carolina School of Medicine; Department of Cell Biology and Anatomy, University of South Carolina School of Medicine; WJB Dorn Veteran Affairs Medical Center, Columbia, South Carolina. Electronic address: - - 2014
Basic pharmacological/transgenic studies have clearly demonstrated a cause-effect relationship between the induction and activation of matrix metalloproteinases (MMPs) and adverse changes in the structure and function of the left ventricle (LV). Thus, regulation of MMP induction and/or activation would appear to be a potential therapeutic target in the context of ...
Maceira Alicia M - - 2014
Cocaine is an addictive, sympathomimetic drug with potentially lethal effects. The prevalence and features of cocaine cardiotoxicity are not well known. We aimed to assess these effects using a comprehensive cardiovascular magnetic resonance (CMR) protocol in a large group of asymptomatic cocaine users. Consecutive (n = 94, 81 males, 36.6 ...
Ramirez Trevi A TA San Antonio Cardiovascular Proteomics Center and Mississippi Center for Heart Research, Department of Biophysics and Physiology, University of Mississippi Medical Center, Jackson, - - 2014
We evaluated whether aliskiren, valsartan, or the combination was protective following myocardial infarction (MI) through effects on matrix metalloproteinase (MMP)-9. C57BL/6J wild type (WT, n=94) and MMP-9 null (null, n=85) mice were divided into 4 groups at 3h post-MI: saline (S), aliskiren (A; 50mg/kg/d), valsartan (V; 40mg/kg/d), or A+V and ...
Asrar Ul Haq Muhammad M Department of Cardiology, The Northern Hospital, Melbourne, - - 2014
Arterial thrombosis in acute coronary syndrome (ACS) is associated with activation of platelets and the coagulation cascade. Persistent thrombin levels have been reported after ACS in such patients. Novel oral anticoagulants without a need of close monitoring and frequent blood tests such as warfarin can provide a chronic beneficial effect ...
Smith Alison A Primary Care Mental Health, Health Services and Population Research Dept, Institute of Psychiatry, Kings College London, De Crespigny Park, London SE5 8AF, - - 2014
Patients can report positive effects of myocardial infarction. It is unknown whether these effects are sustained or what factors influence adaptation. To explore primary care patients' perceptions of the effect of coronary heart disease and to identify possible modifiable predictors of adaptation. Cross-sectional, sub-study of UPBEAT cohort participants. Patients were ...
Jones Huw Bowen HB 1Pathological Sciences, Global Safety Assessment, AstraZeneca Pharmaceuticals, Alderley Park, Macclesfield, - - 2014
Pharmaceutical therapies for non-insulin-dependent diabetes mellitus (NIDDM) include plasma glucose lowering by enhancing glucose utilization. The mitochondrial pyruvate dehydrogenase (PDH) complex is important in controlling the balance between glucose and fatty acid substrate oxidation. Administration of pyruvate dehydrogenase kinase inhibitors (PDHKIs) to rats effectively lowers plasma glucose but results in ...
Conway Aaron A 1 School of Nursing, Queensland University Technology , Kelvin Grove, Queensland, Australia - - 2014
Abstract Background: Trials of new technologies to remotely monitor for signs and symptoms of worsening heart failure are continually emerging. The extent to which technological differences impact the effectiveness of noninvasive remote monitoring for heart failure management is unknown. This study examined the effect of specific technology used for noninvasive ...
Al Mamun Mohammad M Department of Public Health, General Directorate of Health Affairs in Tabuk Region, Ministry of Health, P.O. Box No. 16673, Tabuk 71474, Kingdom of Saudi Arabia. Electronic address: - - 2014
Detailed research initiatives are required to get a clear scenario on complete characterization of environmental triggers in relation to conventional cardiovascular risk factors.
Iqbal Javaid J Department of Cardiovascular Science at the University of Sheffield, and Cardiology Department at Sheffield Teaching Hospitals NHS Trust, Sheffield, - - 2014
EPHESUS was a multicentre, double-blind clinical trial in which 6632 patients with acute myocardial infarction (AMI) complicated by LV systolic dysfunction (LVSD) were randomized to receive eplerenone (n = 3319) or placebo (n = 3313). A total of 1580 EPHESUS patients were treated with PCI, which is now the standard ...
Sato Shinsuke S Department of Neurosurgery, Tokyo Women's Medical University, Tokyo, - - 2014
The sigma-1 receptor has been reported to be associated with diverse biological activities including cellular differentiation, neuroplasticity, neuroprotection, and cognitive functioning of the brain. Fluvoxamine, one of the currently known antidepressants, is a sigma-1 receptor agonist; its effectiveness in treating acute cerebral ischemia has not been reported. We studied the ...
De Silva Kalpa K King's College London British Heart Foundation Centre of Excellence, National Institute for Health Research Biomedical Research Centre at Guy's and St. Thomas's National Health Service Foundation Trust, Cardiovascular Division, The Rayne Institute, London, United - - 2014
This study sought to identify the effect of coronary autoregulation on myocardial perfusion during intra-aortic balloon pump (IABP) therapy. IABP is the most commonly used circulatory support device, although its efficacy in certain scenarios has been questioned. The impact of alterations in microvascular function on IABP efficacy has not previously ...
Romaszko Pawel P a Department of Biochemistry , Medical University of Gdansk , Gdansk , - - 2014
We recently described a new nicotinamide derivative: 4-pyridone-3-carboxamide ribonucleoside (4PYR) and its conversion to intracellular metabolites (4PYR monophosphate: 4PYMP and 4PYR adenylate diphosphate: 4PYRAD). The aim of this study was to clarify the metabolism and physiological effects of brief exposure to 4PYR in perfused rat heart. Rat hearts were perfused ...
Asanuma Hiroshi H 1] Department of Cardiovascular Science and Technology, Kyoto Prefectural University School of Medicine, Kyoto, Japan [2] Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, - - 2014
Carperitide is effective for heart failure (HF) owing to its diuretic and vasodilatory effects. This recombinant peptide may also have direct cardioprotective effects because carperitide reduces the severity of heart failure and limits infarct size. Because coronary vasodilation is an important cardioprotective treatment modality, we investigated whether carperitide increased coronary ...
Akturk I F IF Department of Cardiology, Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery, Training and Research Hospital, Istanbul, Turkey - - - 2014
We aimed to investigate the effects of verapamil and adenosine in an adjunct to intravenous tirofiban on management and prognosis of noreflow phenomenon during primary percutaneous coronary intervention (PPCI) and to compare their efficacies on reversing of noreflow phenomenon and short and midterm survival. We included 46 patients with acute ...
Wang Qian Q Tissue Mechanics Laboratory, Biomedical Engineering Department, Georgia Institute of Technology, Atlanta, GA 30313, United - - 2014
This study was to investigate the mechanisms of ischemic mitral regurgitation (IMR) by using a finite element (FE) approach. IMR is a common complication of coronary artery disease; and it usually occurs due to myocardial infarction. The pathophysiological mechanisms of IMR have not been fully understood, much debate remains about ...
Tofield Andros - - 2014
People's perception of the effect of stress on their health is linked to risk of myocardial infarction according to a study.
Maslov L N LN Research Institute of Cardiology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia, - - 2014
Hypoxic preconditioning produces an infarct-limiting effect both in the early and delayed periods. The increase in heart resistance to ischemia-repefusion was more pronounced after early preconditioning. Hypoxic preconditioning did not change heart resistance to the arrhythmogenic effect of coronary occlusion and reperfusion.
Zhernakova N I NI Belgorod State National Research University, Belgorod, - - 2014
Administration of Cytoflavin to young rats with experimental myocardial ischemia was followed by activation of mitochondrial enzymes and significant accumulation of ATP in the myocardium and blood plasma, but did not modulate the stability of cardiomyocyte membranes and signs of hypoxia. Cytoflavin increased the severity of metabolic disorders and depleted ...
Takayama Hiroo H aDivision of Cardiothoracic Surgery bDivision of Cardiology, New York Presbyterian Hospital, Columbia University Medical Center, New York, New York, - - 2014
To provide a comprehensive update on the current state of short-term, continuous-flow ventricular assist devices (CF-VADs) in the treatment of refractory cardiogenic shock in Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) 1 patients. The mortality rate associated with refractory cardiogenic shock remains markedly elevated, with INTERMACS 1 profile repeatedly ...
Purcell Brendan P BP Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, - - 2014
Inhibitors of matrix metalloproteinases (MMPs) have been extensively explored to treat pathologies where excessive MMP activity contributes to adverse tissue remodelling. Although MMP inhibition remains a relevant therapeutic target, MMP inhibitors have not translated to clinical application owing to the dose-limiting side effects following systemic administration of the drugs. Here, ...
Cong Xiaoqiang X Department of Cardiology, Bethune First Hospital of Jilin University, Changchun, Jilin 130021, P.R. - - 2014
The role of resveratrol (Res) in inflammation induced by ischemia/reperfusion is not well understood. The aim of the present study was to investigate whether Res modulates neutrophil accumulation and tumor necrosis factor‑α (TNF‑α) induction in an ischemia/reperfusion‑injured rat heart model. The rats were randomly exposed to sham surgery, myocardial ischemia/reperfusion ...
Kisvári Gábor G Departments of Pharmacology and Pharmacotherapy, University of Szeged, Albert-Szent Györgyi Medical Centre, Szeged, - - 2014
The present study has examined the effects and the possible mechanisms of a single dose of simvastatin on the severity of arrhythmias resulting from a 25min occlusion and reperfusion of the left anterior descending coronary artery in anaesthetized (chloralose and urethane) dogs. The control animals (n=16) were given the solvent ...
Molenaar Peter P Faculty of Health, QUT, Brisbane; School of Medicine, University of Queensland and Critical Care Research Group, The Prince Charles Hospital, Chermside, QLD, 4032, Australia, - - 2014
The β-blockers carvedilol and metoprolol provide important therapeutic strategies for heart failure treatment. Therapy with metoprolol facilitates the control by phosphodiesterase PDE3, but not PDE4, of inotropic effects of catecholamines in human failing ventricle. However, it is not known whether carvedilol has the same effect. We investigated whether the PDE3-selective ...
de Jong Renate R From the Department of Cardiology, Thoraxcenter, Erasmus University Medical Center, Rotterdam, the Netherlands (R.d.J., J.H.H., S.S., E.B.); and Department of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands - - 2014
Several cell-based therapies for adjunctive treatment of acute myocardial infarction have been investigated in multiple clinical trials, but the benefits still remain controversial. This meta-analysis aims to evaluate the efficacy of bone marrow-derived mononuclear cell (BMMNC) therapy in patients with acute myocardial infarction, but also explores the effect of newer ...
López-Olañeta Marina M MM Cardiovascular Development and Repair Dept. - - 2014
Ventricular remodelling following myocardial infarction progressively leads to loss of contractile capacity and heart failure. Although calcineurin promotes maladaptive cardiac hypertrophy, we recently showed that the calcineurin splicing variant CnAβ1 has beneficial effects on the infarcted heart. However, whether this variant limits necrosis or improves remodelling is still unknown, precluding ...
Bergmeijer Thomas O TO Department of Cardiology, St Antonius Hospital, Nieuwegein, The Netherlands. Electronic address: - - 2014
In patients with ST-segment elevation myocardial infarction (STEMI) who undergo primary percutaneous coronary intervention (pPCI), the use of dual antiplatelet therapy is essential to prevent atherothrombotic complications. Therefore, patients are treated with acetylsalicylic acid and clopidogrel, prasugrel, or ticagrelor. Clopidogrel, however, shows a major interindividual variation in antiplatelet effect, which ...
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