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Hong KyungPyo K Department of Bioengineering, University of Utah, Salt Lake City, UT, USA; UCAIR, Department of Radiology, University of Utah, Salt Lake City, UT, - - 2014
Both post-contrast myocardial T1 and extracellular volume (ECV) have been reported to be associated with diffuse interstitial fibrosis. Recently, the cardiovascular magnetic resonance (CMR) field is recognizing that post-contrast myocardial T1 is sensitive to several confounders and migrating towards ECV as a measure of collagen volume fraction. Several recent studies ...
Cakmak Sabit S Population Studies Division, Environmental Health Science and Research Bureau, Health Canada, 50 Columbine Driveway, Ottawa, ON K1A 0K9, Canada. Electronic address: - - 2014
Acute increases in ambient air pollution have been associated with increased hospitalization for cardiac diseases and stroke. Triggering of cardiac arrhythmia by changes in air quality could theoretically predispose individuals to cardiac arrest or heart failure, or stroke through precipitation of atrial fibrillation. We investigated the association between air quality ...
Krumholz Harlan M HM Yale University School of Medicine, Yale School of Public Health, & Yale-New Haven Hospital, New Haven, CT - - 2014
-The past decade focused intensely on improving the quality of care for people with, or at risk for, cardiovascular disease and stroke. We sought to quantify the changes in hospitalization rates and outcomes during this period. -We used national Medicare data to identify all Fee-For-Service patients aged ≥65 years hospitalized ...
Price Matthew J MJ Scripps Clinic, La Jolla, California. Electronic address: - - 2014
Transcatheter left atrial appendage (LAA) ligation may represent an alternative to oral anticoagulation for stroke prevention in atrial fibrillation. This study sought to assess the early safety and efficacy of transcatheter ligation of the LAA for stroke prevention in atrial fibrillation. This was a retrospective, multicenter study of consecutive patients ...
Lau Yee C YC University of Birmingham Centre for Cardiovascular Sciences, City Hospital , Birmingham , - - 2014
Introduction: Atrial fibrillation (AF) is the most common arrhythmia and brings about significant mortality and morbidity as a result of heart failure and ischemic stroke. Besides vitamin K antagonists (VKA), several new pharmacological agents (nonvitamin K antagonist oral anticoagulants [NOACs]) and procedures have since been developed to improve stroke prevention ...
Bönner Florian F Department of Molecular Cardiology, Heinrich Heine University Düsseldorf, Universitätsstr. 1, 40225, Düsseldorf, - - 2014
Healing of the myocardium after infarction comprises a variety of local adaptive processes which contribute to the functional outcome after the insult. Therefore, we aimed to establish a setting for concomitant assessment of regional alterations in contractile function, morphology, and immunological state to gain prognostic information on cardiac recovery after infarction. For ...
Wu Ling L Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, - - 2014
To explore the clinical effects of a calcium channel blocker compared with an angiotensin II receptor blocker in hypertensive patients, the authors collected data from randomized controlled trials. The pooled outcomes were all-cause mortality, stroke, myocardial infarction, and heart failure. Eight head-to-head trials enrolling 25,084 patients were included. There was ...
Lum Cheemun C From the Interventional Neuroradiology Section, Department of Medical Imaging-Diagnostic (C.L., M.E.A., S.P., R.T., D.I., H.L., M.d.S.) and Division of Neurology, Department of Medicine (M.H., D.D.), The Ottawa Hospital, Ottawa Hospital Research Institute (OHRI), University of Ottawa, Ottawa, Ontario, Canada. - - 2014
Recanalization rates are higher in acute anterior stroke treated with stent-retrievers when compared with older techniques. However, some still have sizeable infarcts and poor outcome. This may be related to underestimation of core infarct on nonenhanced computed tomography (NECT). CT angiography (CTA) source images (CTASI) and CT perfusion may be ...
Yankelson Lior L Department of Cardiology, Tel Aviv Sourasky Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, - - 2014
Two important causes of sudden death during endurance races are arrhythmic death and heat stroke. However, "arrhythmic death" has caught practically all the attention of the medical community whereas the importance of heat stroke is less appreciated. The study sought to determine what percentage of life-threatening events during endurance races ...
Tokgoz Serhat S Department of Neurology, Meram School of Medicine, Necmettin Erbakan University, Konya, - - 2014
Neutrophil/lymphocyte ratio (NLR) is related with increased mortality in both myocardial infarction and acute ischemic stroke. It remains unclear whether NLR is a simple marker of ischemic infarct volume or an independent marker of stroke mortality. The aim of this study is to investigate the relationship of NLR with infarct ...
Martínez-Sánchez Patricia - - 2014
Backgroundour objective was to examine the plasma levels of three biological markers involved in cerebral ischemia (IL-6, glutamate and TNF-alpha) in stroke patients and compare them with two different rat models of focal ischemia (embolic stroke model- ES and permanent middle cerebral artery occlusion ligation model-pMCAO) to evaluate which model ...
Murthy Santosh B SB Department of Neurology, Baylor College of Medicine, 6501 Fannin, NB 302, Houston, TX 77030, - - 2014
Neurogenic stunned myocardium (NSM) after subarachnoid hemorrhage (SAH) is well known, but there is a paucity of data regarding its occurrence following acute stroke. The aim of this study is to investigate the clinical characteristics of NSM in acute non-hemorrhagic stroke. We performed an electronic literature search with Medline and ...
Velagapudi Poonam P Department of Cardiovascular Medicine, University of Missouri-Columbia, School of Medicine, Columbia, MO, - - 2014
Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia and approximately 18-45% of AF patients have concomitant coronary artery disease (CAD). Several studies have demonstrated that oral anticoagulation is the mainstay of therapy for stroke prevention in AF. Similarly, antiplatelet therapy including aspirin and P2Y12 inhibitor is recommended in the ...
Mayer Otto O Jr 2(nd) Department of Internal Medicine, Medical Faculty of Charles University and University Hospital, Pilsen, Czech Republic; Biomedical Center, Medical Faculty of Charles University, Pilsen, Czech Republic. Electronic address: - - 2014
Due to improved analytical performance of the newest generation of troponin assays, several patients have mild elevations of this parameter. Nevertheless, they do not show any signs of acute coronary syndrome. We speculated whether non-acute cardiac troponin I (cTnI) concentrations may improve prediction of residual mortality risk in clinically stable ...
Malik Nitin N Neuroradiology Division, Department of Radiology, University of Virginia, Charlottesville, - - 2014
Leptomeningeal collaterals improve outcome after stroke, including reduction of hemorrhagic complications after thrombolytic or endovascular therapy, smaller infarct size, and reduction in symptoms at follow-up evaluation. The purpose of this study was to determine the demographic and clinical variables that are associated with a greater degree of cerebral collaterals. Clinical ...
Yamamoto Nobuaki N Department of Clinical Neurosciences, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. Electronic address: - - 2014
It is difficult to predict neurologic deterioration in patients with small-vessel occlusion (SVO), that is, small infarcts in the territory of cerebral perforating arteries. We reviewed 110 patients with SVO who were admitted to our hospital. We divided them into groups with (n = 32, group 1) and without deterioration (n = 78, group ...
Seo Jae-Young JY From the Departments of Neurology (J.-Y.S., K.B.L., J.-G.L., J.-S.K., H.R., M.-Y.A.) and Cardiology (B.W.P., M.S.H.), Soonchunhyang University School of Medicine, Seoul, - - 2014
Left ventricular diastolic dysfunction (LVDD) is a predictor for atrial fibrillation (AF). This study was aimed to investigate whether LVDD in cryptogenic ischemic stroke (CS) could be a clue to stroke mechanism. The clinical and echocardiographic findings of 1589 consecutive patients with acute ischemic stroke or transient ischemic attack between ...
Alli Oluseun O The Division of Cardiovascular Diseases and Department of Internal Medicine, University of Alabama, Birmingham, AL, - - 2014
Left atrial appendage device occlusion for the preventions of systemic thromboembolism and stroke represents a major breakthrough in the field of cardiovascular disease. The wide prevalence of atrial fibrillation with devastating consequences of thromboembolic stroke as a result of thrombus arising from the left atrial appendage has led to the ...
Zafrir Barak B Department of Cardiovascular Medicine, Lady Davis Carmel Medical Center and The Ruth and Bruce Rappaport School of Medicine, Technion-Israel Institute of Technology, Haifa, Israel - - 2014
Impaired cardiorespiratory fitness (CRF) is a potent risk factor for mortality in diabetes, and may modify the relation between adiposity and mortality. We evaluated the interaction between CRF and abdominal adiposity distribution with all-cause mortality, myocardial infarction or stroke in patients with diabetes. We studied 294 type 2 diabetics without ...
Zhang Changqing C From the Department of Neurology, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China (C.Z., Yilong Wang, X. Zhao, L.L., C.W., Y.P., X. Zou, W.D., J.J., Y.P., Yongjun Wang); INI Stroke Network, OSF Healthcare System, University of Illinois College of Medicine, Peoria (D.W.); and Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, China - - 2014
Single subcortical infarction (SSI) may be classified as proximal SSI (pSSI) or distal SSI (dSSI) according to its location within the middle cerebral artery territory. Few studies have examined the differences in clinical outcome between the 2. Our study investigated such differences in patients with pSSI or dSSI and examined ...
Boelman Cyrus C Division of Neurology, Hospital for Sick Children, Toronto, - - 2014
To assess the safety and efficacy of antithrombotic therapy (ATT) for secondary stroke prevention of childhood bacterial meningitis. A retrospective study of cases of stroke associated with bacterial meningitis in 2 pediatric hospitals during a period of 15 years. Patients were included in the study if between 28 days and 18 years of ...
Binsell-Gerdin Emil E Department of Public Health and Clinical Medicine, Östersund, Umeå University, Sweden. Electronic address: - - 2014
Hemorrhagic stroke is a rare but serious complication after an acute myocardial infarction (AMI). The aims of our study were to establish the incidence, time trends and predictors of risk for hemorrhagic stroke within 30days after an AMI in 1998-2008. We collected data from the Register of Information and Knowledge ...
Sharma Abhishek A Department of Medicine, Maimonides Medical Center, Brooklyn, NY. Electronic address: - - 2014
To investigate the relationship of body mass index (BMI) with total mortality, cardiovascular (CV) mortality, and myocardial infarction (MI) after coronary revascularization procedures (coronary artery bypass grafting [CABG] and percutaneous coronary intervention [PCI]). Systematic search of studies was conducted using PubMed, CINAHL, Cochran CENTRAL, Scopus, and the Web of Science ...
López-Cancio Elena E Department of Neurosciences, Germans Trias i Pujol University Hospital, Badalona, - - 2014
Background: There are limited data on the specific mechanisms of stroke in patients with intracranial atherosclerotic stenosis (ICAS). We undertook this study to describe infarct patterns and likely mechanisms of stroke in a large cohort of patients with ICAS, and to evaluate the relationship of these infarct patterns to angiographic ...
Sędkowska Agnieszka - - 2014
INTRODUCTION  Impaired glucose tolerance (IGT) has a negative impact on the outcome of patients with acute myocardial infarction (AMI). OBJECTIVES Based on the result of oral glucose tolerance test 560 patients with IGT were selected out of a single center registry of 2733 consecutive patients with AMI (395 men, 165 women). Sex ...
Thomassin Stefanie S SS From the Department of Family Medicine, Drexel University, Philadelphia, PA. - - 2014
Taste and smell disorders have multiple causes. We describe a patient in whom atrial fibrillation and subsequent embolic stroke was discovered because of complaints of decreased smell and taste. These deficits ultimately improved after treatment of the atrial fibrillation along with anticoagulation medication for stroke prevention.
Ungru Kathrin K Department of Mathematics and Computer Science, University of Münster, Münster, - - 2014
Multiple statistics show that heart diseases are one of the main causes of mortality in our highly developed societies today. These diseases lead to a change of the physiology of the heart, which gives useful information about characteristic and severity of the defect. A fast and reliable diagnosis is the ...
Kim Jinkwon J From the Department of Neurology, CHA Bundang Medical Center, CHA University, Seongnam, Gyeonggi-do, Korea (J.K.); Department of Neurology, Ewha Womans University, Seoul, Korea (T.-J.S.); and Departments of Neurology (J.K., E.H.K., K.J.L., D.S., H.S.N., Y.D.K., J.H.H.) and Biostatistics (H.S.L., C.M.N.), Yonsei University College of Medicine, Seoul, - - 2014
We investigated whether the brachial-ankle pulse wave velocity (baPWV) has prognostic value for predicting functional outcome after acute cerebral infarction and whether the prognostic value differs between stroke subtypes. We included 1091 consecutive patients with first-ever acute cerebral infarction who underwent baPWV measurements. Stroke subtypes were classified using the Trial ...
Zhu Wenbin W Department of Anesthesiology & Perioperative Medicine, Oregon Health & Science University, Portland, OR, 97239, - - 2014
RTL1000 is a partial human MHC molecule coupled to a human myelin peptide. We previously demonstrated that RTL1000 was protective against experimental ischemic stroke in HLA-DR2 transgenic (DR2-Tg) mice. Since thrombolysis with recombinant tissue plasminogen activator (t-PA) is a standard therapy for stroke, we determined if RTL1000 efficacy is altered ...
Violi Francesco F Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, - - 2014
An enhanced risk of cardiovascular mortality has been observed after pneumonia. Epidemiological studies have shown that respiratory tract infections are associated with an increased risk of thrombotic-related vascular disease such as myocardial infarction, ischemic stroke and venous thrombosis. Myocardial infarction and stroke have been detected essentially in the early phase ...
Haugaa Kristina H KH Department of Internal Medicine/Division of Cardiovascular Diseases, Mayo Clinic, Rochester, - - 2014
QT prolongation on ECG is a risk marker of ventricular arrhythmias and all-cause mortality. Left ventricular hypertrophy (LVH) on ECG is also associated with poor outcome. Patients satisfying ECG voltage criteria for LVH frequently show concomitant QT prolongation. To explore the impact of marked QT prolongation on all-cause mortality in ...
Giugliano Robert P RP From the Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (R.P.G., C.T.R., S.D.W., C.L., N.D., S.A.M., L.T.G., E.M.A., E.B.); Department of Neurology, Massachusetts General Hospital, Boston (N.S.R., S.S.); Biostatistics, Quintiles, Inc, Durham, NC (J.M.B.); and Daiichi Sankyo, Inc, Pharma Development, Edison, NJ (A.D., J.D., M.S., M.M.). - - 2014
The once-daily oral factor Xa inhibitor, edoxaban, is as effective as warfarin in preventing stroke and systemic embolism while decreasing bleeding in a phase III trial of patients with atrial fibrillation at moderate-high stroke risk. Limited data regarding cerebrovascular events with edoxaban were reported previously. We analyzed the subtypes of ...
Martínez-Rubio Antoni A Department of Cardiology, University Hospital of Sabadell (University Autònoma de Barcelona), Barcelona, Spain - - 2014
In the majority of patients with non-valvular atrial fibrillation (AF) anticoagulation is required to reduce the risk of stroke. Although vitamin K antagonists effectively reduce the risk of stroke, they have many disadvantages that limit their use. Rivaroxaban is a new once-daily oral anticoagulant that overcomes some of these limitations ...
Bauters Christophe C Centre Hospitalier Régional et Universitaire de Lille, Lille, France Inserm U744, Institut Pasteur de Lille, Université Lille Nord de France, Lille, France Faculté de Médecine de Lille, Lille, - - 2014
To assess the association of ß-blocker use with cardiovascular mortality in patients with stable coronary artery disease (CAD). We analysed the data of 4184 outpatients included in a prospective cohort study on stable CAD. Two groups were formed based on ß-blocker use at enrolment. Two propensity score analyses were performed ...
Bangalore Sripal S From the Division of Cardiology, New York University School of Medicine (S.B., F.F.); and Division of Cardiology, Virginia Commonwealth University, Richmond (B.T.). - - 2014
Coronary artery bypass graft surgery (CABG) compared with percutaneous coronary intervention (PCI) reduces mortality in patients with diabetes mellitus. However, prior trials compared CABG with balloon angioplasty or older generation stents, and it is not known if the gap between CABG and PCI can be reduced by newer generation drug-eluting ...
Scordo Kristine Anne KA Kristine Anne Scordo is a professor and director of the AG-ACNP Program at Wright State University, Dayton, Ohio. Kim Anne Pickett is a family nurse practitioner at Medical Group of the Carolinas (endocrinology), Spartanburg, - - 2014
Hypertension, if not appropriately treated, can lead to stroke, kidney failure, myocardial infarction, and death. Substantial evidence from multiple randomized clinical trials demonstrates the benefit of antihypertensive therapy. Healthcare providers seek scientific evidence by which to base treatments. The purpose of this article is to discuss current hypertension guidelines.
van Oeffelen A A M AA Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The - - 2014
To investigate differences in 28-day and 5-year mortality and 5-year readmission after a first hospitalisation for acute myocardial infarction (AMI) and congestive heart failure (CHF) between first generation ethnic minority groups (henceforth, migrants) and the ethnic Dutch population. Nationwide prospective cohorts of first hospitalised AMI (N=213 630) and CHF patients (N=189 069) ...
Lindberg Søren S Department of Cardiology P, Gentofte University Hospital, Copenhagen, Denmark - - 2014
Atrial natriuretic peptide (ANP) is released from the atria (on cleavage of proANP) in response to elevated intra-atrial pressure and wall stretch. Clinical data on proANP are still limited, mainly due to limitations in assaying the protein, which recently have been solved. ProANP is elevated in cardiovascular disease and predicts ...
Willey Joshua Z JZ Department of Neurology, Division of Stroke and Cerebrovascular Diseases. Electronic address: - - 2014
Cerebral infarction and hemorrhage are among the principal sources of morbidity and mortality associated with mechanical circulatory support. There has been particular concern with the recently reported increased rate of device thrombosis in continuous-flow left ventricular assist devices. The neurologic management of stroke among these patients has limited data to ...
Robinson Austin A AA Department of Internal Medicine, Yale School of Medicine, New Haven, - - 2014
Few prospective studies support the use of anticoagulation during the acute phase of ischemic stroke, though observational data suggest a role in certain populations. Depending on the mechanism of stroke, systemic anticoagulation may prevent recurrent cerebral infarction, but concomitantly carries a risk of hemorrhagic transformation. In this article, we describe ...
Mahajan Sanket K SK Faculty, ICCU, Lilavati Hospital and Research Centre , Bandra, Mumbai, India - - 2014
Stroke following coronary interventions is a devastating and most dreaded complication with significant morbidity and mortality. Various factors have been ascribed for this complication including the technical errors. We hereby describe such a patient who presented to us with the diagnosis of acute coronary syndrome and underwent percutaneous coronary intervention ...
Kfoury Elias E Inova Fairfax Hospital, Virginia, USA - - 2014
Multiple studies have evaluated the effect of anesthesia type on carotid endarterectomy with inconsistent results. Our study compared 30-day postoperative myocardial infarction, stroke, and mortality between carotid endarterectomy under local or regional anesthesia and carotid endarterectomy under general anesthesia utilizing National Surgical Quality Improvement Program database. All patients listed in ...
Lau Kui Kai - - 2014
Patients with myocardial infarction are at risk of the development of atrial fibrillation (AF) and ischemic stroke. We sought to evaluate the prognostic performance of the CHADS2- and CHA₂DS₂-VASc scores in predicting new AF and/or ischemic stroke in post-ST segment elevation myocardial infarction (STEMI) patients. 607 consecutive post-STEMI patients with ...
Ozkul-Wermester Ozlem O Department of Neurology, Rouen University Hospital, Rouen, - - 2014
Background/Purpose: Perfusion computed tomography (CT) is capable of measuring the permeability surface product (PS). PS reflects the permeability of the blood-brain barrier, involved in the pathophysiology of hemorrhagic transformation (HT) of ischemic stroke. The aim of our study was to determine if an increased PS can predict HT. Methods: A ...
Sheth Sunil A SA Department of Neurology, University of California Los Angeles, Los Angeles, California, - - 2014
The ideal population of patients for endovascular therapy (ET) in acute ischemic stroke remains undefined. Recent ET trials have moved towards selecting patients with proximal middle cerebral artery (MCA) or internal carotid artery occlusions, which will likely leave a gap in our understanding of the treatment outcomes of M2 occlusions. ...
Kikkert Wouter J WJ Academic Medical Center-University of Amsterdam, Amsterdam, the - - 2014
This study sought to investigate the prognostic value of access site bleeding (ASB) and non-ASB for recurrent ischemic outcomes and mortality in patients with ST-segment elevation myocardial infarction (STEMI). The prognostic value of ASB-related complications after STEMI is subject to debate. The prognostic value of ASB and non-ASB for 1-year ...
Brown Devin L DL Stroke Program, The Cardiovascular Center - Stroke Program, 1500 E. Medical Center Drive - SPC#5855, Ann Arbor, MI 48109-5855, USA. Electronic address: - - 2014
Association between cerebral infarction site and poststroke sleep-disordered breathing (SDB) has important implications for SDB screening and the pathophysiology of poststroke SDB. Within a large, population-based study, we assessed whether brainstem infarction location is associated with SDB presence and severity. Cross-sectional study was conducted on ischemic stroke patients in the ...
Singh Vikas V Cardiovascular Division, and the Elaine and Sydney Sussman Cardiac Catheterization Laboratory, University of Miami Hospital, Miller School of Medicine, 1400 N.W. 12th Avenue, Suite 1179, Miami, FL, 33136, - - 2014
The estimated annual incidence of new and recurrent myocardial infarction (MI) in the U.S. is 715,000 events. Primary percutaneous coronary intervention (PCI) is the reperfusion strategy of choice in most patients with acute ST-elevation myocardial infarction (STEMI). Recent advances in percutaneous techniques and devices, including manual aspiration catheters and newer ...
Hussain Sarah K SK The University of Virginia, Charlottesville, VA, USA, - - 2014
Atrial fibrillation (AF) is the most commonly encountered clinical arrhythmia, and stroke prevention remains an integral part of management of AF. Long-term therapy with oral anticoagulants, though effective, has many limitations, and these limitations have encouraged the search for device-based alternatives. In patients with non-valvular AF, approximately 90 % of thrombi ...
Mazya Michael V MV From the Department of Neurology, Karolinska University Hospital (M.V.M., N.A., N.W.) and Department of Clinical Neuroscience (M.V.M., N.A., N.W.), Karolinska Institutet, Stockholm, Sweden; Stroke Research Group, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom (G.A.F.); Department of Neurology, University of Leipzig, Leipzig, Germany (C.H.); International Clinical Research Center, Neurology Department, St Anne's Hospital, Brno, Czech Republic (R.M.); and Stroke Unit, Centro Hospitalar Lisboa Central, Lisbon, Portugal - - 2014
Intracerebral hemorrhage after treatment with intravenous recombinant tissue-type plasminogen activator for ischemic stroke can occur in local relation to the infarct, as well as in brain areas remote from infarcted tissue. We aimed to describe risk factors, 3-month mortality, and functional outcome in patients with the poorly understood complication of ...
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