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Finsterer Josef J Second Medical Department, Krankenanstalt Rudolfstiftung, Vienna, - - 2014
Juvenile, 'cryptogenic' stroke from left-ventricular hypertrabeculation/noncompaction (LVHT) missed on transthoracic echocardiography (TTE) but present on transesophageal echocardiography (TEE) has not been reported before. A 31-year-old Caucasian male experienced a small acute embolic ischemic stroke in the anterior territory of the left median-cerebral artery. He had a history of epilepsy until ...
Broughton Brad R S BR From the Vascular Biology and Immunopharmacology Group, Department of Pharmacology, Monash University, Clayton, Victoria, Australia (B.R.S.B., V.H.B., H.A.K., S.L., H.X.C., C.V.G.-M., E.G., M.A.E., A.A.M., G.R.D., C.G.S.); and School of Biomedical Sciences, University of Queensland, Brisbane, Queensland, Australia - - 2014
Experimental studies indicate that estrogen typically, but not universally, has a neuroprotective effect in stroke. Ischemic stroke increases membrane-bound G protein-coupled estrogen receptor (GPER) distribution and expression in the brain of male but not female mice. We hypothesized that GPER activation may have a greater neuroprotective effect in males than ...
Martin Lorelle L Department of Cardiology, Austin Health, Australia; LaTrobe University School of Nursing, Australia. Electronic address: - - 2014
Coronary heart disease is the most common condition affecting Australians. The time sensitive nature of treating ST-segment elevation myocardial infarction (STEMI) has been the subject of extensive research for several years. Despite important advances in strategies to reduce time to treatment, time continues to represent a major determinant of mortality ...
Hausegger Klaus A KA Department of Diagnostic and Interventional Radiology, Klinikum Klagenfurt, Feschnigstrasse 11, 9020, Klagenfurt, Austria, - - 2014
Mechanical thrombectomy (MTE) in patients with acute ischemic infarct caused by large-vessel occlusion is becoming used with increasing frequency in many stroke centers. With the introduction of stent retrievers, recanalization rates >80 % are reached by most operators. However, although the technical success rate of MTE has been increased, clinical results ...
Connolly-Andersen Anne-Marie AM Umeå University, Umeå, - - 2014
We recently observed that cardiovascular causes of death were common in patients with hemorrhagic fever with renal syndrome (HFRS), which is caused by hantaviruses. But it is not known whether HFRS is a risk factor for acute cardiovascular events: acute myocardial infarction (AMI) and stroke. Personal identification numbers from the ...
Hoda Md Nasrul MN Department of Medical Laboratory, Imaging and Radiologic Sciences, Georgia Regents University, Augusta, GA, USA, - - 2014
Remote ischemic conditioning is neuroprotective in young male rodents after experimental stroke. However, it has never been tested in females whom remain at higher risk of stroke injury after menopause. We tested remote ischemic perconditioning therapy (RIPerC) at 2 h after embolic stroke in ovariectomized (OVX) female mice with and without ...
Goel Kashish K Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, - - 2014
 An inverse association between BMI and mortality has been reported in patients with coronary heart disease and heart failure. This 'obesity paradox' has recently been reported in other disease states, including stroke, hypertension, incident diabetes, atrial fibrillation, hemodialysis and transcatheter aortic valve replacement. Cardiorespiratory fitness influences the obesity paradox and ...
Amin Hardik H Yale New Haven Hospital, LCI Building, 10th floor, 15 York Street, New Haven, CT, 06520, - - 2014
Ischemic strokes are a significant cause of morbidity and mortality in the United States. They may be due to large artery atherosclerosis, small vessel occlusion, cardioembolism, or other less common mechanisms such as toxins, hypercoagulable disorders, and vasospasm. Each mechanism carries its own risk of recurrence and prognosis. Strokes without ...
Leary Megan C MC Department of Neurology, Harvard Clinical Research Institute, Boston, MA, - - 2014
An arrhythmia is defined as an abnormal heart rhythm. Certain arrhythmias have much higher rates of neurologic complications, including stroke, cognitive impairment, and dementia. The purpose of this paper is to review both the direct and indirect causes of neurologic problems caused by arrhythmias. Direct complications from arrhythmia can include ...
Moran John F JF Division of Cardiology, Loyola University Medical Center, Maywood, IL, USA. Electronic address: - - 2014
Cardiomyopathies have a variety of causes: infectious, genetic, valvular heart disease, coronary artery disease, hypertension, and tachycardias. All can result in myocardial dysfunction and often congestive heart failure. The main interaction between a diagnosis of heart disease and the brain is via embolic stroke. The focus here is on myocardial ...
Arch Allison E AE Department of Neurocritical Care and Emergency Neurology, Yale University School of Medicine, 15 York Street, LCI Suite 710, New Haven, CT, 06510, USA, - - 2014
Malignant infarction implies a large middle cerebral artery (MCA) stroke that leads to rapid clinical deterioration and edema formation, and can be associated with hemorrhagic transformation, herniation, and poor functional outcomes, including death. Malignant edema is brain edema formation that occurs in the setting of large territory infarction. This review ...
Turner Jennifer J Maidstone and Tunbridge Wells NHS Trust, Tunbridge Wells Hospital, Kent, - - 2014
This case series highlights two patients seen in the same stroke centre presenting with unusual symptoms. They were later diagnosed with bilateral thalamic infarcts, probably related to an unusual anatomical variant. The difficulties in establishing the diagnoses due to their relative rarity and complexity could have impacted on patient outcomes.
Pinto Antonio - - 2014
Stroke is the second cause of death worldwide and one of the leading cause of disability. Due to the high rate of recurrence, in high risk-patients (eg patients affected by atherosclerotic vascular disease), long-term antiplatelet therapy reduces the risk of vascular events such as non-fatal myocardial infarction, non-fatal stroke, or ...
Di Raimondo Domenico - - 2014
Among the different subtypes of ischaemic strokes, almost 20 % are of cardiac origin. Different are the causes of cardioembolic stroke, but the most common is the atrial fibrillation, a supraventricular arrhythmia. Appropriate use of antiplatelet drugs and anticoagulants after transient ischaemic attack (TIA) or ischaemic stroke depends on whether ...
Whitlock Richard R Department of Surgery, McMaster University, Hamilton, Canada ; ; Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada - - 2014
Occlusion of the left atrial appendage (LAA) is a promising approach to stroke prevention in atrial fibrillation (AF). However, evidence of its efficacy and safety to date is lacking. We herein describe the rationale and design of a definitive LAA occlusion trial in cardiac surgical patients with AF. We plan ...
Satow Takeshi T Department of Neurosurgery, Nagahama City Hospital, Nagahama, - - 2014
Astasia is a rare presenting symptom of stroke, usually known as 'thalamic astasia', induced by a lesion in the ventrolateral thalamus. We report a case of caudal cingulate infarction manifesting astasia. A 58-year-old male presented with inability to sit, stand and walk (astasia). No apparent motor weakness was noticed in ...
Taina Mikko M Department of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland; Unit of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland; Unit of Radiology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, - - 2014
Left atrial appendage (LAA) volume has been shown to be increased in patients with acute cryptogenic stroke. Atrial fibrillation (AF) is a well-recognized risk factor but it is not the only one associated with LAA enlargement. The aim of the study was to clarify the multifactorial etiology of LAA enlargement ...
Kim Joon-Tae JT Department of Neurology, Cerebrovascular Center, Chonnam National University Hospital, Gwangju, Korea ; Biomedical Research Institute, Chonnam National University Hospital, Gwangju, - - 2014
There have been neither appropriate guidelines nor clinical studies about the use of antithrombotics after hemorrhagic transformation (HT). We sought to find whether the use of antithrombotics after hemorrhagic infarction might be associated with aggravation of HT and neurological deterioration. This retrospective study included prospectively registered consecutive patients with acute ...
Harston George W J GW Radcliffe Department of Medicine, Oxford, - - 2014
Lacunar infarction is traditionally ascribed to lipohyalinosis or microatheroma. We report the case of 40-year-old man, without traditional risk factors for ischemic stroke, who presented to the Emergency Department with recurrent episodes of transient right-sided weakness and paresthesia. Lacunar infarction was confirmed on diffusion-weighted MRI and blood tests showed a ...
Silver Brian B Director, Stroke Center, Rhode Island Hospital; Associate Professor of Neurology, The Warren Alpert Medical School of Brown - - 2014
Over the last decade, a number of advances in the care of stroke and TIA patients have been made. These advances include prevention, acute management, and recovery. Some of this work has occurred in Rhode Island. This review will focus on the revised definition of stroke and TIA; short-term risk ...
Abeysinghe Hima C S HC Department of Surgery, St Vincent's Campus, University of Melbourne, Victoria, - - 2014
The extent of stroke damage in patients affects the range of subsequent pathophysiological responses that influence recovery. Here we investigate the effect of lesion size on development of new blood vessels as well as inflammation and scar formation and cellular responses within the subventricular zone (SVZ) following transient focal ischemia ...
Wakisaka Kayo K Division of Cerebrovascular Medicine, Kyushu Rosai - - 2014
A 73-year-old man was admitted to our hospital because of a decrease in spontaneity. His medical history included two stroke episodes, probably related to hypertension. Brain MRI on admission demonstrated acute infarction in the right caudate nucleus and left putamen. Intravenous infusion of a low molecular-weight heparin added to oral ...
Sun Yu-Yo YY Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia, United States of - - 2014
Edaravone, a potent antioxidant, may improve thrombolytic therapy because it benefits ischemic stroke patients on its own and mitigates adverse effects of tissue plasminogen activator (tPA) in preclinical models. However, whether the combined tPA-edaravone therapy is more effective in reducing infarct size than singular treatment is uncertain. Here we investigated ...
Romero Jorge J Department of Medicine, Division of Cardiology, Albert Einstein College of Medicine, Bronx, NY, - - 2014
Atrial fibrillation (AF) increases the risk for thromboembolic stroke five-fold. The left atrial appendage (LAA) has been shown to be the main source of thrombus formation in the majority of strokes associated with AF. Oral anticoagulation with warfarin and novel anticoagulants remains the standard of care; however, it has several ...
Buckley Kathleen M KM Charlie Norwood VA Medical Center, Augusta, GA, USA ; Department of Cellular Biology & Anatomy, Georgia Regents University, Augusta, GA, - - 2014
The role of autophagy in response to ischemic stroke has been confusing with reports that both enhancement and inhibition of autophagy decrease infarct size and improve post-stroke outcomes. We sought to clarify this by comparing pharmacologic modulation of autophagy in two clinically relevant murine models of stroke. We used rapamycin ...
Lund Robert W - - 2014
Determine the overall mortality after lacunar infarction and compare it to the overall mortality afterothrombotic and cardioembolic strokes. Determine the pattern of increased mortality over time after lacunar infarction. The clinical literature was searched for articles providing mortality data on lacunar infarction having at least 5 years of post stroke ...
White Harvey D HD Green Lane Cardiovascular Service, Auckland City Hospital and Auckland University, Auckland, New Zealand - - 2014
Clinical trials traditionally use time-to-first-event analysis embedded within the composite endpoint of cardiovascular death (CVD), myocardial infarction (MI), or stroke. However, many patients have >1 event, and this approach may not reflect overall experience. We addressed this by analyzing all cardiovascular events in TRACER. TRACER randomized 12 944 patients with ...
Price Matthew J MJ Division of Cardiovascular Diseases, Scripps Clinic, La Jolla, - - 2014
Atrial fibrillation (AF) is a major cause of stroke and systemic embolism. Although warfarin and the novel oral anticoagulants reduce thromboembolic risk, they are associated with an ongoing bleeding hazard, in addition to other limitations that deter their use. The left atrial appendage (LAA) appears to be the primary source ...
Zhang Ming M . - - 2014
Cerebrovascular accidents (CVAs) frequently coexist with coronary artery disease (CAD) and adversely affect prognosis in patients with CAD; however, fewer studies have investigated the role of prior ischemic stroke on the outcomes of percutaneous coronary intervention (PCI). The aim of this study was to determine the safety and effectiveness of ...
He Jingyu J Department of Emergency, Xuanwu Hospital, Capital Medical University NO. 45, Changchun Street, Xicheng, Beijing 100053, - - 2014
Neutrophil-to-lymphocyte ratio (NLR) has been reported to predict cardiovascular risks and mortality in coronary artery diseases. We aimed to evaluate the capacity of NLR to predict long-term mortality in Chinese patients presenting with ST-segment elevation myocardial infarction (STEMI). We recorded NLR at admission, 24 or 72 hours after admission, and ...
Lee Jeong Hyun JH Neurovascular Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA - - 2014
Rho-associated kinase (ROCK) is a key regulator of numerous processes in multiple cell types relevant in stroke pathophysiology. ROCK inhibitors have improved outcome in experimental models of acute ischemic or hemorrhagic stroke. However, the relevant ROCK isoform (ROCK1 or ROCK2) in acute stroke is not known. We characterized the pharmacodynamic ...
Sabashnikov Anton - - 2013
A two-stage explantation of a left ventricular assist device (LVAD) was performed on 47 year old afro-american gentlemen with non-ischemic dilated cardiomyopathy (DCM) who was successfully bridged to recovery. After he suffered a stroke caused by a VAD thrombosis with embolisation, the VAD outflow graft was first ligated using minimally-invasive ...
Lin Yinyao Y Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, No. 600 Tianhe Road, Guangzhou, Guangdong 510630, - - 2013
To evaluate the features of risk factors and etiological subtypes of brainstem infarctions (BSIs) patients in China. One hundred and ninety-nine cerebral infarction patients with brainstem involvement were categorized into five groups according to Trial of Org 10172 in Acute Stroke Treatment classification: large artery disease (LAD), cardioembolism (CE), small ...
Friedrich B B Departments of Neuroradiology and Neurology, Klinikum Rechts der Isar, Munich, - - 2013
BACKGROUND AND PURPOSE:In acute stroke, CTP is often used to visualize the endangered brain areas, including the ischemic core and the penumbra. Our goal was to assess the evolution of the infarct after mechanical thrombectomy and to analyze the interventional factors determining the fate of the penumbra.MATERIALS AND METHODS:All patients ...
Cotter Gad G Momentum Research, Inc., Durham, NC, USA, - - 2013
Acute heart failure (AHF) is one of the most common causes of hospital admission. Despite the very high short-term morbidity and mortality and high costs associated with the condition, little progress has been made toward an understanding of the complex mechanisms of AHF, and particularly the spike in mortality after ...
Guinot P-G PG Anaesthesiology and Critical Care Department, Amiens University Hospital, Place Victor Pauchet, Amiens 80054, - - 2013
/st>This study was designed to assess the ability of the stroke volume respiratory variation (ΔrespSV) determined by oesophageal Doppler monitoring (ODM) to predict the response to volume expansion (VE) during pneumoperitoneum. The predictive value of ΔrespSV was evaluated according to the concept of the 'grey zone'. /st>Patients operated on laparoscopy ...
Toma Mustafa M Division of Cardiology, St. Paul's Hospital, University of British Columbia, Vancouver, - - 2013
Acute decompensated heart failure (ADHF) is associated with significant morbidity and mortality but the relationship between LVEF and outcomes is unclear. We explored the association between LVEF and 30 and 180 day mortality in 7007 ADHF patients enrolled in the Acute Studies of Nesiritide in Decompensated Heart Failure (ASCEND-HF) trial. We ...
Hannan Edward L EL University at Albany, State University of New York, Albany, New York. Electronic address: - - 2013
Several randomized controlled trials and observational studies have compared outcomes of percutaneous coronary interventions (PCIs) with drug-eluting stents (DESs) and coronary artery bypass grafting (CABG), but they have not thoroughly investigated the relative difference in outcomes for patients aged ≥75 years. In this study, a total of 3,864 patients receiving DES ...
Kurzepa Jacek - - 2013
Abstract There is a continuous urgent need to explore the pathogenesis and biochemical changes within the infarcted area during acute ischemic stroke (IS). Matrix metalloproteinases (MMPs), prevailing extracellular endopeptideses, can digest proteins located extracellulary proteins, eg. collagen, proteoglycans, elastin or fibronectin. Among MMPs, gelatinases (MMP-2 and MMP-9) are the most ...
Ishibashi Akira - - 2013
A novel free radical scavenger, edaravone, has been demonstrated to exert a neuroprotective effect and improve outcomes in acute ischemic stroke, but there have been few clinical studies. Therefore, we investigated retrospectively whether the administration of edaravone at the acute stage of ischemic stroke can improve outcomes of the disease ...
Gupta Deepak K - - 2013
The complex relationship between left atrial (LA) structure and function, electrical burden of atrial fibrillation (AF) and stroke risk is not well understood. We aimed to describe LA structure and function in AF. Left atrial structure and function was assessed in 971 subjects enrolled in the echocardiographic substudy of ENGAGE ...
Hedna Vishnumurthy S VS Department of Neurology, University of Florida, Gainesville, - - 2013
The development of effective neurobiological adjuvants to rehabilitation of paresis caused by stroke will depend on understanding mechanisms of paresis. Our objective was to determine the extent to which upper-limb (UL) paresis after nonlacunar ischemic middle cerebral artery (MCA) distribution stroke is caused by infarction of posterior periventricular white matter ...
Kefer Joëlle J Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium. - - 2013
The aim of the present study was to evaluate the procedural feasibility, the safety and the 1-year outcome following left atrial appendage (LAA) closure using the Amplatzer cardiac plug (ACP) in Belgium. Data were prospectively collected among 90 consecutive patients, undergoing LAA closure with an ACP in 7 Belgian centres ...
Berkhemer Olvert A OA Division of Diagnostic and Interventional Neuroradiology, Department of Imaging, Massachusetts General Hospital, 55 Fruit Street GRB 241, Boston, MA 02114, USA ; Harvard Medical School, Boston, MA, USA ; Department of Radiology, Academic Medical Center Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The - - 2013
Despite high rates of early revascularization with intra-arterial stroke therapy, the clinical efficacy of this approach has not been clearly demonstrated. Neuroimaging biomarkers will be useful in future trials for patient selection and for outcomes evaluation. To identify patients who are likely to benefit from intra-arterial therapy, the combination of ...
Wu Teddy Y - - 2013
We examined the impact of major earthquakes on acute stroke admissions by a retrospective review of stroke admissions in the 6weeks following the 4 September 2010 and 22 February 2011 earthquakes. The control period was the corresponding 6weeks in the previous year. In the 6weeks following the September 2010 earthquake ...
Tietze Anna - - 2013
Chemical exchange saturation transfer (CEST)-derived, pH-weighted, amide proton transfer (APT) MRI has shown promise in animal studies for the prediction of infarction risk in ischemic tissue. Here, APT MRI was translated to patients with acute stroke (1-24 h post-symptom onset), and assessments of APT contrast, perfusion, diffusion, disability and final infarct ...
Athappan Ganesh - - 2013
Studies have suggested that the early excess risk of stroke in coronary artery bypass grafting (CABG) may be compensated for by a slow but progressive catch-up phenomenon in patients undergoing percutaneous coronary intervention (PCI). We therefore undertook this analysis to compare the temporal stroke risk between PCI and CABG in ...
Piccini Jonathan P - - 2013
Atrial fibrillation increases the risks of stroke, heart failure, and death, and anticoagulation therapy increases the risk of gastrointestinal haemorrhage. However, the relative event rates for these outcomes are not well described. We sought to define the risks of major clinical events in older adults after a new diagnosis of ...
Lau K K - - 2013
Both blood pressure (BP) and its variability (BPV) are established risk factors for development of atherosclerotic disease and are associated with an increased risk for cardiovascular and all-cause mortality. The prognostic implications of outpatient clinic visit-to-visit BPV amongst patients with lacunar infarction are nevertheless unknown. The clinical outcome of 281 ...
Kohli Payal - - 2013
Nonsteroidal anti-inflammatory drugs (NSAIDs) other than aspirin have been linked to heart failure, salt retention, adverse ventricular remodeling, and thrombosis. We therefore sought to assess their impact on cardiovascular events in outpatients with stable atherothrombotic disease. We analyzed 44,095 patients in the REduction of Atherothrombosis for Continued Health (REACH) registry ...
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