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Rosanio Salvatore S Department of Internal Medicine, Division of Cardiology, University of North Texas Health Science Center, Fort Worth, TX, United States. Electronic address: - - 2014
This systematic review aims to provide an update on pharmacology, efficacy and safety of the newer oral direct thrombin and factor Xa inhibitors, which have emerged for the first time in ~60years as cogent alternatives to warfarin for stroke prophylaxis in non-valvular atrial fibrillation. We also discuss on four of ...
Guidoni S V SV Department of Neuroscience, Mental Health and Sensory Systems, NESMOS, 'Sapienza' University of Rome, Rome, Italy, - - 2014
Tako-tsubo cardiomyopathy (TTC), also known as "stress induced cardiomyopathy", is an acute cardiac condition characterized by transient myocardial dysfunction associated with a peculiar pattern of reversibile left ventricular ballooning that mimics myocardial infarction, but with normal coronary arteries. Tako-tsubo cardiomyopathy typically occurs in postmenopausal women and it is often triggered ...
Nielsen Susanne S Susanne Nielsen, MSc PhD Student, Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden. Kristin Falk, PhD Senior Lecturer, Institute of Health and Care Sciences, Sahlgrenska Academy, University of Gothenburg, Sweden. Anna Gyberg, MSc Faculty of Education, Institute of Health and Care Sciences, Sahlgrenska Academy, University of Gothenburg, Sweden. Sylvia Määttä, PhDAdjunct Senior Lecturer, Institute of Health and Care Sciences, Sahlgrenska Academy, University of Gothenburg, Sweden. Lena Björck, PhD Senior Lecturer, Department of Molecular and Clinical Medicine, and Institute of Health and Care Sciences, and Institute of Health and Care Sciences, Sahlgrenska Academy, University of Gothenburg, - - 2014
Previous studies have shown that people hesitate to seek medical attention when experiencing the initial symptoms of acute myocardial infarction (AMI), but the reasons why and the events underpinning the decision-making process are unclear. The aim of this study was to describe the actions and experiences involved in the process ...
Tütüncü Serdar S Departments of Neurology (S.T., J.F.S., M.E., C.H.N.). Electronic address: - - 2014
Stroke with tandem occlusion within the anterior circulation presents a lower probability of recanalization and good clinical outcome after intravenous (IV) thrombolysis than stroke with single occlusion. The present study describes the impact of endovascular procedures (EPs) compared with IV thrombolysis alone on recanalization and clinical outcome. Thirty patients with ...
English Joey D JD Departments of Radiology and Biomedical Imaging, San Francisco, California, - - 2014
The rabbit small clot embolic model for large vessel occlusion (LVO) is well established, yet has limitations. Blind introduction of autologous thrombus often fails to completely occlude a target vessel and, when successful, the precise timing of occlusion and revascularization is difficult to control. Studies of cellular biology and neuroimaging ...
Saito Shin S Hirosaki Stroke and Rehabilitation Center, Hirosaki, Japan. Electronic address: - - 2014
We report a case of a nonvalvular atrial fibrillation (NVAF) patient with acute cardioembolic stroke in whom rivaroxaban, an oral direct factor Xa inhibitor, reduced a smoke-like echo in the left atrium and resolved a thrombus in the left atrial appendage. A 71-year-old man was admitted because of the sudden ...
Ntaios G G Department of Medicine, Medical School, University of Thessaly, Larissa, - - 2014
There is no strong evidence that all ischaemic stroke types are associated with high cardiovascular risk. Our aim was to investigate whether all ischaemic stroke types are associated with high cardiovascular risk. All consecutive patients with ischaemic stroke registered in the Athens Stroke Registry between 1 January 1993 and 31 ...
Oygarden H H Department of Neurology, Haukeland University Hospital, Bergen, Norway; Institute of Clinical Medicine, University of Bergen, Bergen, - - 2014
There is increasing knowledge about an association between migraine and ischaemic stroke. Cortical spreading depression (CSD) is the probable biological substrate of migrainous aura. To investigate the influence of CSD on the apparent stroke - migraine association, we hypothesized that magnetic resonance (MR) diffusion weighted images of acute ischaemic stroke ...
Opthof T T Department of Clinical and Experimental Cardiology, Heart Failure Research Center, Academic Medical Center, Meibergdreef 9, Room K2-111, 1105 AZ, Amsterdam, the Netherlands, - - 2014
The impact factor of the Netherlands Heart Journal was stable at about 1.4 between 2009 and 2012. In 2013 it will break through the 2.0 barrier for the first time.
Kajermo Ulf U From the Skaraborgs Hospital, Skövde, Sweden (U.K.); Östersunds Hospital, Östersund, Sweden (A.U., A.M.); Karolinska Institutet, Solna, Sweden (T.J.); and Umeå University, Umeå, Sweden - - 2014
Ischemic stroke is a known complication of acute myocardial infarction (AMI). Treatment of AMI has undergone great changes in recent years. We aimed to investigate whether changes in treatment corresponded to a lower incidence of ischemic stroke and which factors predicted ischemic stroke after AMI. Data were taken from the ...
Kim Anthony S - - 2014
The potential for cardioembolic stroke has important implications for clinical management. This review describes the diagnostic workup and management options for this key stroke subtype. The suspicion for a cardioembolic source for stroke is raised with a large vessel occlusion or when strokes occur in multiple vascular territories. Diagnostic workup ...
de Figueiredo Marcelo Marinho MM Departamento de Neurologia e Neurocirurgia, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, - - 2014
Atrial fibrillation is a common arrhythmia that increases the risk of stroke by four- to five-fold. We aimed to establish a profile of patients with atrial fibrillation from a population of patients admitted with acute ischemic stroke or transient ischemic attack using clinical and echocardiographic findings. We evaluated patients consecutively ...
Hart Robert G RG McMaster University/Population Health Research Institute, Hamilton Health Sciences, Hamilton, - - 2014
Atrial fibrillation is a common, potentially preventable cause of disabling stroke in the elderly, particularly in elderly women, resulting from embolism of stasis-precipitated thrombi formed in the left atrial appendage. In 1989, the first randomized clinical trial of anticoagulant therapy in atrial fibrillation showed that warfarin produced a large reduction ...
Ozkan Buğra B aDepartment of Cardiology, Bucak State Hospital, Burdur bDepartment of Cardiology, Gümüşhane State Hospital, Gümüşhane cDepartment of Internal Medicine, Mersin State Hospital, Mersin dDepartment of Cardiology, Adana Numune Training and Research Hospital, Adana eDepartment of Cardiology, Gazi University Faculty of Medicine, Ankara fDepartment of Cardiology, Kayseri Training and Research Hospital, Kayseri and gDepartment of Neurology, Bucak State Hospital, Burdur - - 2014
Stroke is the leading cause of disability worldwide. It is known that atrial fibrillation and left atrial enlargement contribute ischemic stroke, and mean platelet volume (MPV) increases in patients with ischemic stroke and atrial fibrillation. We aimed to determine whether higher MPV is associated with ischemic stroke in patients with ...
Pierdomenico Sante D SD Dipartimento di Medicina e Scienze dell'Invecchiamento, Università Gabriele d'Annunzio, Chieti, - - 2014
The independent prognostic significance of left atrial enlargement is not yet completely clear. We investigated the association between left atrial enlargement and risk of ischemic stroke in elderly treated hypertensive patients. The occurrence of ischemic stroke was evaluated in 1,191 elderly treated hypertensive patients (age range = 60-90 years). Left ...
Loh Joshua P JP Interventional Cardiology, MedStar Washington Hospital Center, Washington, - - 2014
To determine whether door-to-balloon (DTB) times of patients presenting with ST-elevation myocardial infarction (STEMI) were reduced in patients transported by emergency medical services (EMS) compared to those who were self-transported. DTB time is an important measure of hospital care processes in STEMI. Use of EMS may expedite in-hospital processing and ...
Lassnig Elisabeth E Cardiology and Intensive Care Medicine, Department of Internal Medicine II, Klinikum Wels-Grieskirchen, Griekirchner Strasse 42, 4600, Wels, Austria, - - 2014
Heat stroke is a life-threatening condition due to an acute thermoregulatory failure during exposure to high environmental temperatures. We report a series of four cases (three exertional, one classic heat stroke) during the heat wave of July 2013 in Austria. All of them presented with a core temperature > 41 °C, central ...
Kara K K Department of Cardiology, University Hospital Essen, Essen, - - 2014
B-type natriuretric peptide (BNP) is a marker of cardiac dysfunction that is released from myocytes in response to ventricular wall stress. Previous studies suggested that BNP predicts stroke events in addition to classical risk factors. It was suggested that the BNP-associated risk results from coronary atherosclerosis or atrial fibrillation. Three ...
Reddy Prabashni P 1Center for Drug Policy, Partners Healthcare, Needham, MA, - - 2014
Rivaroxaban, a direct factor Xa inhibitor, is a novel oral anticoagulant approved for stroke prevention in patients with nonvalvular atrial fibrillation and also approved in Europe (but not in the United States) to prevent recurrent ischemic events in patients with recent acute coronary syndromes. Advantages of rivaroxaban over oral anticoagulants ...
D'Ascenzo Fabrizio F Division of Cardiology, University of Turin; Meta-analysis and Evidence based medicine Training in Cardiology (METCARDIO). Electronic address: - - 2014
Percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) perform similarly in terms of lowering mortality and myocardial infarction rates in patients with stable angina, except in subjects with high-risk lesions. PCI is burdened from higher rates of revascularization, but offers a reduction in stroke. To date, the impact ...
Yuxuan Hu H Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, - - 2014
Cardiac resynchronization therapy (CRT) has been demonstrated to lead to the restoration of oxygen consumption homogeneity throughout the left ventricle (LV), which is important for long-term reverse remodeling of the ventricles. However, research has focused exclusively on identifying the LV pacing sites that led to acute hemodynamic improvements. It remains ...
- - 2014
Essential facts Atrial fibrillation (AF) causes an abnormal, sometimes fast pulse, and is the most common heart rhythm disturbance. It occurs when electrical impulses controlling the heart's natural rhythm lose co-ordination. People with AF have a four or five times higher risk of stroke because it increases the risk of ...
Tan Song S Department of Neurology, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu, 610041, Sichuan, People's Republic of - - 2014
Few prospective studies have examined the frequency, predictors and long-term outcomes of spontaneous hemorrhagic transformation (HT) in patients with ischemic stroke not receiving thrombolytic treatment. We prospectively enrolled a consecutive cohort of 407 patients with ischemic stroke who were admitted within one month of stroke onset. In patients who developed spontaneous ...
Wong Jonathan M JM Doris Duke Clinical Research Fellowship Program, University of California, San Francisco, California; Department of Medicine, California Pacific Medical Center, San Francisco, - - 2014
This study sought to determine whether left atrial (LA) dysfunction independently predicts ischemic stroke. Atrial fibrillation (AF) impairs LA function and is associated with ischemic stroke. However, ischemic stroke frequently occurs in patients without known AF. The direct relation between LA function and risk of ischemic stroke is unknown. We ...
Spina R R Department of Cardiology, St Vincent's Hospital, Sydney, New South Wales, - - 2014
An elderly woman presented to our attention because of paroxysmal atrial fibrillation and cerebrovascular events requiring systemic anticoagulation and a concomitant, serious bleeding diathesis (the Osler-Weber-Rendu syndrome, or hereditary haemorrhagic telangiectasia). Her risk of suffering a major stroke was significant given a CHA2 DS2 VASc score of 6. However, she ...
Bastos Ana A Departamento de Epidemiologia Clínica, Medicina Preditiva e Saúde Pública. Faculdade de Medicina. Universidade do Porto. Porto. Portugal. Instituto de Saúde Pública. Universidade do Porto. Porto. Portugal.. - - 2014
Introduction: The quality of health information in the Internet may be low. This is a concerning issue in cardiovascular diseases which warrant patient self-management. We aimed to assess the quality of Portuguese websites as a source of health information on acute myocardial infarction and stroke. Material and Methods: We used ...
Sposato Luciano A LA From the Department of Clinical Neurological Sciences, London Health Sciences Centre, Western University, London, - - 2014
Poststroke atrial fibrillation (AF) represents up to 1 of 4 overall AF cases in acute ischemic stroke. Current guidelines recommend oral anticoagulation for every ischemic stroke patient in whom AF is diagnosed. However, in some cases, AF detected after acute ischemic stroke may be short-lasting and perhaps a nonrecurrent autonomic ...
Feng Chao C Yiwu Affiliated Hospital of Zhejiang University, School of Medicine, Zhejiang, China. Electronic address: - - 2014
Patients of small subcortical infarction sometimes have neurologic deterioration (ND), with the risk factors and specific pathogenesis unclear. Small subcortical infarction is often accompanied by other phenotypes of small vessel disease such as leukoaraiosis, which indicates the white matter hyperintensities in the deep or periventricular areas on the fluid-attenuated inversion ...
Marks Michael P MP From Stanford Stroke Center, Stanford University School of Medicine, Palo Alto, - - 2014
Our aim was to determine the relationships between angiographic collaterals and diffusion/perfusion findings, subsequent infarct growth, and clinical outcome in patients undergoing endovascular therapy for ischemic stroke. Sixty patients with a thrombolysis in cerebral infarction (TICI) score of 0 or 1 and internal carotid artery/M1 occlusion at baseline were evaluated. ...
Lee Jung-Gon JG Department of Neurology, Soonchunhyang University, College of Medicine, Seoul, - - 2014
Intracranial arterial calcification (IAC) is an evidence of advanced atherosclerosis. This study was aimed to investigate whether IAC predicts early vascular events (EVEs) during acute period of ischemic stroke. We prospectively enrolled consecutive patients with acute ischemic stroke and transient ischemic attack within 48 hours from January 2005 to October 2012. ...
Llombart Víctor - - 2014
Stroke is one of the main causes of death and disability in the world. Cardioembolic etiology accounts for approximately one fifth of all ischemic strokes whereas 25-30% remains undetermined even after an advanced diagnostic workup. Despite there is not any biomarker currently approved to distinguish cardioembolic stroke among other etiologies ...
Seizer Peter P Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls-Universität Tübingen, - - 2014
Cyclophilin A (CyPA) is an abundantly expressed intracellular protein. It exerts a variety of functions due to its peptidyl-prolyl cis-trans isomerase (PPIase) activity. When released into the extracellular space CyPA binds to its extracellular receptor CD147 (EMMPRIN), and thereby initiates a cascade of inflammatory processes. Recent data indicate that both ...
Bostan Cem C Department of Cardiology, Institute of Cardiology, Istanbul University, Haseki, - - 2014
In this study, we aimed to elucidate the factors affecting long-term all-cause mortality in patients with hypertrophic cardiomyopathy (HCM). We retrospectively examined 31 patients (22 males and 9 females) diagnosed with HCM from 1999 to 2013. All subjects had sinus rhythm at the time of evaluation. Four patients had history ...
Ford Andria L AL Department of Neurology, Washington University School of Medicine, St. Louis, MO, - - 2014
While several MRI parameters are used to assess tissue perfusion during hyperacute stroke, it is unclear which is optimal for measuring clinically relevant reperfusion. We directly compared mean transit time (MTT) prolongation (MTTp), time-to-peak (TTP), and time-to-maximum (Tmax) to determine which best predicted neurological improvement and tissue salvage following early ...
Arboix Adrià A Department of Neurology, Cerebrovascular Division, Hospital Universitari del Sagrat Cor, Universitat de Barcelona, C/Viladomat 288, E-08029 Barcelona, Catalonia, - - 2014
Symptomatic lacunar ischemic stroke (25% of all brain infarctions) results from occlusion of a single penetrating artery by microatheromas or lipohyalinosis and rarely from an intracranial atheromatous branch disease. Recurrent lacunar stroke may be associated with more severe clinical features and has been involved in producing lacunar state and vascular ...
Gawlitza Matthias M University of Leipzig, Department of Neuroradiology, Liebigstrasse 20, 04103 Leipzig, Germany. Electronic address: - - 2014
To investigate the relation between DWI-PWI mismatch and FLAIR-hyperintense vessel (FHV) sign and their influence on the prediction of the infarct growth in stroke patients without vessel recanalising therapy. Thirty-three patients with non-lacunar acute stroke and not eligible for recanalisation therapy received cerebral MRI at the day of admission and ...
Pandey Sanjay S Department of Neurology, RN 507, Academic Block, GB Pant Hospital, JLN Marg, New Delhi 110002, India. Electronic address: - - 2014
Movement disorders are common following cerebrovascular accidents and they can be hyperkinetic, including hemichorea and hemiballismus, or hypokinetic, as seen in parkinsonian disorders. Monochorea has also been reported due to stroke, albeit rarely. We report a 47-year-old gentleman who presented with a history of sudden onset choreiform movement of his ...
Lu Alex Y AY Department of Neurosurgery, Yale School of Medicine, 100 York Street Apt 9G, New Haven, CT, 06510, USA, - - 2014
The devastation caused by acute ischemic strokes is evident in every intensive care unit across the world. Although there is no doubt that progress has been made in treatment, it has been slow to come. With the emergence of new technologies in imaging, thrombolysis and endovascular intervention, the treatment modalities ...
Serrone Joseph C JC *Department of Neurosurgery, University of Cincinnati, Cincinnati, Ohio; ‡Department of Neurosurgery, University of Florida-Jacksonville, Jacksonville, - - 2014
: Of the approximately 795 000 strokes in the United States annually, 87% are ischemic and result in significant morbidity and mortality. Improvements in acute ischemic stroke (AIS) outcomes have been achieved with intravenous thrombolytics (IVT) and intra-arterial thrombolytics vs supportive medical therapy. Given its ease of administration, noninvasiveness, and most ...
Agarwalla Pankaj K PK Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, - - 2014
: Anterior and posterior circulation acute ischemic stroke carries significant morbidity and mortality as a result of malignant cerebral edema. Decompressive craniectomy has evolved as a viable neurosurgical intervention in the armamentarium of treatment options for this life-threatening edema. In this review, we highlight the history of craniectomy for stroke ...
Moss Joshua D JD Section of Cardiology, Department of Internal Medicine, University of Chicago, 5758 S. Maryland Ave, MC 9024, Chicago, IL, 60637, USA, - - 2014
Stroke prevention is of vital importance in the management of atrial fibrillation (AF), though the proven strategy of systemic anticoagulation for thromboembolic prophylaxis is underutilized for a variety of reasons. The left atrial appendage (LAA) has long been suspected as the principal source of arterial emboli, particularly in nonvalvular AF, ...
Alvarez Vincent V From the Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, - - 2014
Although the incidence of acute seizures after ischemic strokes is small, about 1.2%-4.2%,(1,2) they still represent a substantial clinical challenge. There are no clear management guidelines, and the effect on stroke outcome is a matter of debate.(3) Moreover, experiencing a seizure at the stroke onset may represent a relative contraindication ...
Wijdicks Eelco F M - - 2014
There are uncertainties surrounding the optimal management of patients with brain swelling after an ischemic stroke. Guidelines are needed on how to manage this major complication, how to provide the best comprehensive neurological and medical care, and how to best inform families facing complex decisions on surgical intervention in deteriorating ...
Gattringer Thomas T Department of Neurology, Medical University of Graz, Graz, - - 2014
Background: Patients with transient ischemic attack (TIA) and stroke have an increased risk for subsequent cardiac events including myocardial infarction (MI), which might be associated with a worse clinical outcome. Rapid identification of stroke patients at higher risk for MI might foster intensified cardiac monitoring or certain therapeutic strategies. However, ...
Harskamp Ralf E RE Duke Clinical Research Institute and Duke University Medical Center, Durham, NC; Academic Medical Center-University of Amsterdam, Amsterdam, The Netherlands. Electronic address: - - 2014
Hybrid coronary revascularization (HCR) represents a minimally invasive revascularization strategy in which the durability of the internal mammary artery to left anterior descending artery graft is combined with percutaneous coronary intervention to treat remaining lesions. We performed a systematic review and meta-analysis to compare clinical outcomes after HCR with conventional ...
Finitsis Stephanos S Neuroradiologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany, - - 2014
This study aimed to relate growth of the infarct core with time to recanalization in patients receiving mechanical recanalization in whom the time of recanalization is known. We analyzed data from patients with anterior circulation acute ischemic stroke who underwent mechanical recanalization. Demographic and angiographic characteristics, initial apparent diffusion coefficient ...
Finsterer Josef J Second Medical Department, Krankenanstalt Rudolfstiftung, Vienna, - - 2014
Juvenile, 'cryptogenic' stroke from left-ventricular hypertrabeculation/noncompaction (LVHT) missed on transthoracic echocardiography (TTE) but present on transesophageal echocardiography (TEE) has not been reported before. A 31-year-old Caucasian male experienced a small acute embolic ischemic stroke in the anterior territory of the left median-cerebral artery. He had a history of epilepsy until ...
Broughton Brad R S BR From the Vascular Biology and Immunopharmacology Group, Department of Pharmacology, Monash University, Clayton, Victoria, Australia (B.R.S.B., V.H.B., H.A.K., S.L., H.X.C., C.V.G.-M., E.G., M.A.E., A.A.M., G.R.D., C.G.S.); and School of Biomedical Sciences, University of Queensland, Brisbane, Queensland, Australia - - 2014
Experimental studies indicate that estrogen typically, but not universally, has a neuroprotective effect in stroke. Ischemic stroke increases membrane-bound G protein-coupled estrogen receptor (GPER) distribution and expression in the brain of male but not female mice. We hypothesized that GPER activation may have a greater neuroprotective effect in males than ...
Martin Lorelle L Department of Cardiology, Austin Health, Australia; LaTrobe University School of Nursing, Australia. Electronic address: - - 2014
Coronary heart disease is the most common condition affecting Australians. The time sensitive nature of treating ST-segment elevation myocardial infarction (STEMI) has been the subject of extensive research for several years. Despite important advances in strategies to reduce time to treatment, time continues to represent a major determinant of mortality ...
Hausegger Klaus A KA Department of Diagnostic and Interventional Radiology, Klinikum Klagenfurt, Feschnigstrasse 11, 9020, Klagenfurt, Austria, - - 2014
Mechanical thrombectomy (MTE) in patients with acute ischemic infarct caused by large-vessel occlusion is becoming used with increasing frequency in many stroke centers. With the introduction of stent retrievers, recanalization rates >80 % are reached by most operators. However, although the technical success rate of MTE has been increased, clinical results ...
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