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Vefali Huseng H Department of Cardiology, St. Luke's University Health Network, 801 Ostrum Street, Bethlehem, PA, 18015, - - 2015
Coronary artery chronic total occlusion (CTO) has rapidly become a popular target of percutaneous coronary intervention (PCI). Technical and technological advances required for approaching these anatomically complex and challenging lesions have progressed at an extraordinary pace and have led to amazing success rates. Patient selection, however, has primarily focused on ...
Lip Gregory Y H GY University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, United Kingdom; Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Faculty of Health, Aalborg University, Aalborg, Denmark. Electronic address: - - 2014
Non-vitamin K antagonist oral anticoagulants (NOACs) have changed the landscape for stroke prevention in atrial fibrillation (AF). Given the huge burden of AF in Asians, more attention to stroke prevention is clearly needed. Aiming to provide an overview and reappraisal of stroke prevention in Asians with AF, we searched MEDLINE ...
Taylor B B Department of Neurosurgery, Columbia University Medical Center, New York, NY,USA - - - 2014
A decompressive hemicraniectomy is frequently performed for patients with malignant middle cerebral artery territory infarction (MMI) to reduce the intracranial hypertension, which may otherwise result in transtentorial herniation. However, certain clinically significant issues-diagnostic criteria, predictors of the MMI clinical course, benefit of surgery in certain populations, timing of surgery-are unresolved. ...
Luo Xiaobin X Department of Medicine and Research Centre, Montreal Heart Institute and Université de Montréal, 5000 Belanger Street East, Montreal, H1T1C8 QC, - - 2014
Atrial fibrillation (AF), the most common sustained arrhythmia in clinical practice, is an important contributor to cardiac morbidity and mortality. Pharmacological approaches currently available to treat patients with AF lack sufficient efficacy and are associated with potential adverse effects. Even though ablation is generally more effective than pharmacotherapy, this invasive ...
Lorenzo Natalia N Hospital Universitario de La Princesa, Madrid, - - 2014
The use of isotretinoin has been associated with mild changes in the metabolic profile of adolescents. In very rare cases, a possible association with myocardial infarction, stroke and thromboembolic events has been reported. In this report we describe the potential association of isotretinoin with the occurrence of an acute myocardial ...
McQuillan Brendan M BM School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia. - - 2014
While the evidence base for management of acute coronary syndrome (ACS) is extensive, some subgroups have been underrepresented or excluded from relevant clinical trials. These subgroups - such as women, older people, diabetic patients and Indigenous Australians - present clinical challenges for which there is limited evidence to guide optimal ...
Thompson Peter L PL School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia. - - 2014
About half of all patients who experience an acute coronary syndrome (ACS) in Australia have their conditions managed non-invasively - that is, they do not undergo coronary angiography and revascularisation in hospital. ACS patients whose conditions are managed non-invasively may not receive the same level of evidence-based care as those ...
Lambert Thomas T 1st Medical Department of Cardiology, Linz General Hospital, Johannes Kepler University School of Medicine, Krankenhausstraße 9, 4020, Linz, Austria, - - 2014
Patients with resistant arterial hypertension have an increased risk of stroke, myocardial infarction, heart failure, and chronic kidney disease. In many cases, limitations of pharmacological treatment like intolerance and adherence to the antihypertensive medications are present in the clinical setting. In this context, new treatment options like trans-femoral sympathetic renal ...
Serpytis Pranas P Vilnius University, Vilnius University Hospital Santariskiu Clinics Center of Cardiology and Angiology; Vilnius University Faculty of - - 2014
Kawasaki disease appears to be the most common cause of myocardial infarction in children. It draws special attention to itself because of its undisclosed etiopathogenesis and lack of definite diagnostic criteria. Though treatment schemes are established, new approaches appear due to intensive research programes and constantly updating news on etiology, ...
Najafzadeh Mehdi M From the Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA. - - 2014
With proliferating treatment options for anticoagulant therapy, physicians and patients must choose among them based on their benefits and risks. Using a Discrete Choice Experiment, we elicited patients' relative preferences for specific benefits and risks of anticoagulant therapy. We selected a sample of US patients with cardiovascular disease from an ...
Mattila Olli S OS Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland; Research Program of Molecular Neurology, Research Programs Unit, University of Helsinki, Helsinki, Finland; Department of Clinical Neurosciences, University of Helsinki, Helsinki, - - 2014
Cerebral amyloid angiopathy (CAA) predisposes to symptomatic intracerebral hemorrhage (sICH) after combined thrombolytic and anticoagulant treatment of acute myocardial infarction. However, the role of CAA in stroke thrombolysis has not been established. Here, we describe a confirmed case of CAA-related hemorrhage in a patient receiving thrombolysis for acute ischemic stroke. ...
Wallentin Lars L Uppsala Clinical Research Center and Department of Medical Sciences, Uppsala University, Uppsala, - - 2014
Acute coronary syndromes (ACS), either ST-elevation myocardial infarction or non-ST-elevation ACS, are still one of the most common cardiac emergencies with substantial morbidity and mortality. The availability of evidence-based treatments, such as early and intense platelet inhibition and anticoagulation, and timely reperfusion and revascularization, has substantially improved outcomes in patients ...
Albertson Megan - - 2014
Cerebrovascular accidents (CVAs) are the leading cause of disability and the fourth leading cause of death in the U.S. The WHO defines stroke as "rapidly developing clinical signs of focal disturbance of cerebral function lasting more than 24 hours with no apparent cause other than of vascular origin." Strokes are ...
Loffredo Lorenzo L Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy. Electronic address: - - 2014
The aim of this study was to perform a meta-analysis, in patients with atrial fibrillation, to evaluate the impact of new oral anticoagulants (NOACs) anti-IIa and anti-Xa vs warfarin on myocardial infarction incidence. A meta-analysis of double blind randomized controlled trials (RCTs) was performed. Four RCT studies including 84,439 patients ...
Giblett Joel P JP Department of Interventional Cardiology, Papworth Hospital, Cambridge, - - 2014
Ischaemia-reperfusion (IR) injury is an important cause of myocardial damage during percutaneous coronary intervention (PCI). There are few therapies in widespread clinical use which impact on IR injury and it remains an important and underutilized target for treatment in acute myocardial infarction. This review will examine the translational scientific evidence ...
Arbustini Eloisa E Centre for Inherited Cardiovascular Disease, IRCCS Foundation Policlinico San Matteo, Pavia, - - 2014
Whether left ventricular noncompaction (LVNC) is a distinct cardiomyopathy or a morphologic trait shared by different cardiomyopathies remains controversial. Current guidelines from professional organizations recommend different strategies for diagnosing and treating patients with LVNC. This state-of-the-art review discusses new insights into the basic mechanisms leading to LVNC, its clinical manifestations, ...
Petrou Emmanouil E Emmanouil Petrou, Vasiliki Vartela, Anna Kostopoulou, Panagiota Georgiadou, George Athanassopoulos, George Karatasakis, Division of Cardiology, Onassis Cardiac Surgery Center, GR-17674 Athens, - - 2014
Left ventricular wall rupture (LVWR) comprises a complication of acute myocardial infarction (AMI). Acute LVWR is a fatal condition, unless the formation of a pseudoaneurysm occurs. Several risk factors have been described, predisposing to LVWR. High index of suspicion and imaging techniques, namely echocardiography and computed tomography, are the cornerstones ...
Bice Justin S JS School of Pharmacy and Pharmaceutical Sciences, Cardiff University, - - 2014
The protective effect of ischaemic postconditioning (short cycles of reperfusion and reocclusion of a previously occluded vessel) was identified over a decade ago commanding intense interest as an approach for modifying reperfusion injury which contributes to infarct size in acute myocardial infarction. Elucidation of the major mechanisms of postconditioning has ...
Boutsikou Megan Maria MM Division of Cardiology, Onassis Cardiac Surgery Center, 356 Syggrou Ave., GR-17674, Athens, Greece. - - 2014
The patients experiencing an acute coronary event are exposed to increased risk of thromboembolic events. That risk becomes substantially greater when AF fibrillation and heart failure are present as well. Dual antiplatelet therapy remains the gold standard in the treatment of patients with ACS. The combination of an oral anticoagulant ...
Lassandro Francesco F Department of Radiology, Monaldi Hospital, via Leonardo Bianchi, 80131, Naples, Italy, - - 2014
Gas detection in the bowel wall and in portomesenteric venous vessels in adults has long been related to intestinal infarction and poor outcome; many case reports have shown that pneumatosis may be associated with a large variety of pathological situations, ranging from absolutely benign and asymptomatic forms to abdominal catastrophes. ...
Herring Michael J MJ 1 Heart Institute, Good Samaritan Hospital , Los Angeles, - - 2014
A door-to-balloon time of less than 90 minutes is the gold standard for reperfusion therapy to treat acute myocardial infarction (MI). Because 30-day mortality remains ∼10%, new methods must be cultivated to limit myocardial injury. Therapeutic hypothermia has long been experimentally used to attenuate myocardial necrosis during MI with promising ...
Kozak Hasan Hüseyin HH Department of Neurology, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey. Electronic address: - - 2014
Cerebellum provides functions to be maintained at a basal level by regulating mental performance by means of functional and anatomic links critical for cognition structures. The status emerging with the determination of cognitive and affective disorders after the posterior lobe injury of the cerebellum was termed as a "Cerebellar Cognitive ...
Lederman Yitzchok S YS Department of Neurology, Stroke Center, State University of New York (SUNY) Downstate Medical Center, Brooklyn, New - - 2014
QT dispersion (QTd) has been proposed as an indirect electrocardiography (ECG) measure of heterogeneity of ventricular repolarization. The predictive value of QTd in acute stroke remains controversial. We aimed to clarify the relationship between QTd and acute stroke and stroke prognosis. A systematic review of the literature was performed using ...
Pursnani Amit A Cardiac MR PET CT Program, Division of Cardiology and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 165 Cambridge Street, Suite 400, Boston, MA 02114, USA. Electronic address: - - 2014
The recently released 2013 ACC/AHA guidelines for management of blood cholesterol have substantially increased the number of adults who are eligible for preventive statin therapy. We sought to determine whether eligibility for statin therapy as determined by the 2013 ACC/AHA guideline recommendation is better aligned with the actual presence of ...
Engel Josien - - 2014
Cardiac risk scores estimate a patient's risk of future cardiac events or death. They are developed to inform treatment decisions of patients diagnosed with unstable angina or non-ST-elevation myocardial infarction. Despite recommending their use in guidelines and evidence of their prognostic value, they seem underused in practice. The purpose of ...
Garton Alex B AB From the Division of Cardiovascular Disease, Department of Internal Medicine, Lankenau Medical Center, Lankenau Institute of Medical Research, Wynnewood, Pennsylvania; Jefferson Medical College, Philadelphia, - - 2014
Atrial fibrillation is the most common arrhythmia and ablation is becoming more prevalent as a treatment option. Appropriate treatment of atrial fibrillation mandates thromboembolic prophylaxis, and atrial fibrillation ablation periprocedural management of oral anticoagulation is paramount because of the unique susceptibility for thromboembolism that exists for a patient undergoing ablation. ...
Chou Sherry H-Y SH Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA, - - 2014
Molecular biomarkers have revolutionalized diagnosis and treatment of many diseases, such as troponin use in myocardial infarction. Urgent need for high-fidelity biomarkers in neurocritical care has resulted in numerous studies reporting potential candidate biomarkers. We performed an electronic literature search and systematic review of English language articles on cellular/molecular biomarkers ...
Smith Fraser Gd FG Division of Epidemiology and Biostatistics, University of Leeds, UK - - 2014
The purpose of this review was to compare quality of care and outcomes following acute coronary syndrome (ACS) in Central and Eastern European Transitional (CEET) countries. This was a review of original ACS articles in CEET countries from PubMed, ISI Web of Science, Medline and Embase databases published in English ...
Moretti Antonio A Laboratory of Pharmacology and Molecular Medicine of Central Nervous System, Department of Biology and Biotechnology, University of Pavia, - - 2014
Stroke is the third cause of death worldwide and the main cause of chronic, severe adult disability. We focus on acute ischaemic stroke, which accounts for approximately 80% of all strokes. The current therapy aims at restoring cerebral blood flow within a narrow time window in order to prevent damaging ...
Ohman E Magnus EM From the Duke Program for Advanced Coronary Disease, Division of Cardiology, Department of Medicine, and Duke Clinical Research Institute, Duke University, Durham, - - 2014
Should therapies to treat chronic stable angina reduce the risk of major cardiovascular events such as death and myocardial infarction? Although this may be a laudable target, the majority of treatments that are currently in use, such as nitrates, calcium-channel blockers, and beta-blockers, have not been proved to achieve this ...
Hennigan Barry B Department of Cardiology, Golden Jubilee National Hospital, Glasgow, United - - 2014
Aims: The aim of this article is to review what is currently known about fractional flow reserve (FFR) and related coronary physiological indices in patients with acute coronary syndrome (ACS) including non-ST-elevation (NSTEMI) and ST-elevation myocardial infarction (STEMI) with a view to making recommendations for daily practice. Methods and results: ...
Cuisset Thomas T Département de Cardiologie, CHU Timone, Marseille, - - 2014
Multivessel obstructive coronary artery disease is observed in about half of the STEMI patients undergoing primary PCI. Optimal management of non-culprit lesions in these settings continues to be a matter of debate and no consensus has been reached. Lack of robust scientific data led to significant heterogeneity in practice among ...
van Lavieren Martijn A MA AMC Heartcenter, Academic Medical Center, University of Amsterdam, Amsterdam, The - - 2014
Myocardial tissue perfusion remains compromised in 30-40% of patients with ST-segment elevation myocardial infarction (STEMI) despite restored epicardial patency after primary percutaneous coronary intervention (pPCI). This phenomenon is attributed to microvascular dysfunction secondary to numerous pathophysiological mechanisms, including distal embolisation of plaque and thrombus material. Its association with larger post-infarction ...
Pöss Janine J University Hospital Schleswig-Holstein, Campus Lübeck, Department of Internal Medicine/Cardiology/Angiology/Intensive Care Medicine, Lübeck, - - 2014
Aims: This manuscript outlines the treatment of cardiogenic shock (CS) complicating acute myocardial infarction (AMI), focusing on new therapeutic strategies from the interventional cardiologist's perspective. Methods and results: CS is a life-threatening complication of AMI occurring in 10% of AMI patients. It can be defined as a state of critical ...
Brogan Richard A RA Richard A Brogan, Christopher P Gale, Leeds Institute of Cardiovascular and Metabolic Medicine, Division of Epidemiology and Biostatistics, University of Leeds, Leeds LS2 9JT, United - - 2014
Acute coronary syndromes presenting with ST elevation are usually treated with emergency reperfusion/revascularisation therapy. In contrast current evidence and national guidelines recommend risk stratification for non ST segment elevation myocardial infarction (NSTEMI) with the decision on revascularisation dependent on perceived clinical risk. Risk stratification for STEMI has no recommendation. Statistical ...
Yildirim Ufuk U Ondokuz Mayis University, Faculty of Medicine, Department of Cardiology, Samsun, Turkey. Electronic address: - - 2014
We report the case of a female patient under oral prednisolone therapy due to a diagnosis of idiopathic intracranial hypertension with papilledema. Unfortunately, short-term treatment with prednisolone caused an unusual complication in the patient, i.e., recurrent myocardial ischemia. Possible mechanisms leading to this complication were evaluated in the light of ...
Ferreira Mónica P A - - 2014
Nanotechnology has impacted tremendously the medical research with increasing importance in the development of new therapeutic approaches and applications. Among these applications, the use of nanocarriers have gained particular interest in order to achieve successful delivery of therapeutics and imaging agents for the treatment and diagnostics of different diseases, such ...
Kimura Satoshi S Department of Neurology, Fukuoka University, - - 2014
The safety of recombinant tissue plasminogen activator (rt-PA) and/or endovascular therapy for patients using the novel oral anticoagulant (NOAC) for atrial fibrillation remains unclear. We report a patient who was treated by both rt-PA and endovascular thrombectomy who suffered from acute ischemic stroke under treatment with NOAC. An 83-year-old woman ...
Vengoechea Fabian F Jeanes Hospital/Temple University Health System, Philadelphia, PA. - - 2014
The 3 main clinical manifestations of acute coronary syndrome (ACS) are unstable angina, non-ST-segment myocardial infarction, and ST-segment myocardial infarction. Together they comprise a major cause of emergency care and hospitalization in the United States. Consequently, all hospital-based physicians should be familiar with current recommendations regarding the diagnosis and management ...
Zhang Jie J 1 Neuroscience Center, Department of Neurology, 2 Cadre Ward, The First Hospital of Jilin University, Jilin University, Changchun 130021, - - 2014
Hemorrhagic transformation (HT) is a frequent complication of acute ischemic stroke that is especially common after thrombolytic therapy. The risk of HT limits the applicability of tissue plasminogen activator (tPA). Here, we sought to review the rate, classification, predictors, possible mechanism, and clinical outcomes of HT, as well as existing ...
Hohnloser Stefan H - - 2014
Dr Stefan H. Hohnloser reports on the results of the ARISTOTLE and AVERROES trials.
Schwartzberg David D Department of Surgery, Monmouth Medical Center, Long Branch 300 2nd Avenue, Long Branch, NJ 07760, - - 2014
Delirium tremens develops in a minority of patients undergoing acute alcohol withdrawal; however, that minority is vulnerable to significant morbidity and mortality. Historically, benzodiazepines are given intravenously to control withdrawal symptoms, although occasionally a more substantial medication is needed to prevent the devastating effects of delirium tremens, that is, propofol. ...
Jivanji Salim G M SG Royal Brompton Hospital, London, - - 2014
Successful treatment with heart rate lowering medication has been used to treat adults with chronic myocardial dysfunction of various aetiologies for a number of years. There has been recent evidence for the successful use of β-receptor blocking medication in highly selected group of infants with diastolic myocardial dysfunction. This case ...
DeMartini Tony J TJ Prairie Cardiovascular Consultants, 401 E. Carpenter, Springfield, Illinois, USA. - - 2014
Despite a short lag period since its development the retrograde approach has been increasingly integrated within the treatment strategies for the percutaneous treatment of coronary chronic total occlusions. This review article discuss which anatomical features argue most powerfully for its use, the specific skills required for its uptake and the ...
Gupta Prabha Nini PN Department of Cardiology, Medical College Hospital, Trivandrum, Kerala, - - 2014
'The Big four' are the most poisonous snakes in India, and especially in Kerala. These include the cobra, the viper, the krait and the sea snake. Most of the poisonous snakebites in India occur in Kerala. We believe there are only a few reports of myocardial infarction after snakebites and ...
Marsh Elisabeth Breese EB Department of Neurology, The Johns Hopkins University School of Medicine , Baltimore, MD , USA ; Department of Neurology, Johns Hopkins Bayview Medical Center , Baltimore, MD , - - 2014
Intravenous tissue plasminogen activator is the mainstay for the treatment of acute ischemic stroke in patients presenting within 4.5 h of symptom onset. Studies have demonstrated that treating patients early leads to improved long-term outcomes. MR imaging currently allows quantification of the ischemic penumbra in order to better identify individuals most ...
Tsivgoulis Georgios G Department of Neurology, The University of Tennessee Health Science Center , Memphis, TN , USA ; Second Department of Neurology, School of Medicine, University of Athens, Attikon University Hospital , Athens , Greece ; International Clinical Research Center, St. Anne's University Hospital , Brno , Czech - - 2014
Over the past 20 years, clinical research has focused on the development of reperfusion therapies for acute ischemic stroke (AIS), which include the use of systemic intravenous thrombolytics (alteplase, desmoteplase, or tenecteplase), the augmentation of systemic intravenous recanalization with ultrasound, the bridging of intravenous with intra-arterial thrombolysis, the use of multi-modal ...
Abelló David D Department of Medicine and Surgery, Faculty of Medicine and Health Sciences, Rovira i Virgili University, C. Sant Llorenç, s/n, Reus, Catalonia 43201, Spain. - - 2014
Paraoxonases (PON) are three enzymes (PON1, PON2 and PON3) that play a role in the organism's antioxidant system; alterations in which are associated with diseases involving oxidative stress. In this review, we summarize the evidence of PON related to the pathogenesis of coronary artery disease (CAD) and atherosclerosis. We searched ...
Marín García Gerald - - 2014
ST-elevation myocardial infarction (STEMI) is a common presentation in the Emergency Room. Proper treatment requires precision and time saving procedures. Hospitals around the world are currently developing STEMI protocols to optimize this process since mortality and morbidity increase with time without treatment. These protocols may involve Percutaneous Interventions (PCI), fibrinolytics ...
Pyka Lukasz L Department of Heart and Vascular Disease, 3rd Department of Cardiology, Silesian Center for Heart Diseases, Zabrze, - - 2014
Cardiogenic shock (CS) remains the main cause of death in patients with myocardial infarction. Conservative treatment alone does not sufficiently improve prognosis. Mortality in CS can only be significantly reduced with revascularization, both surgical and percutaneous. However some patients present with haemodynamic instability despite optimal medical treatment and complete revascularization, ...
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