Search Results
Results 201 - 250 of 1760
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Greenwood John P - - 2009
Several investigations are currently available to establish the diagnosis of coronary heart disease (CHD). Of these, cardiovascular magnetic resonance (CMR) offers the greatest information from a single test, allowing the assessment of myocardial function, perfusion, viability and coronary artery anatomy. However, data from large scale studies that prospectively evaluate the ...
Jacobson Arnold F AF GE Healthcare, 101 Carnegie Center, Princeton, NJ 08540, USA. - - 2009
ADMIRE-HF (AdreView Myocardial Imaging for Risk Evaluation in Heart Failure) consists of two identical prospective open-label, multicenter, phase 3 studies (MBG311 and MBG312) evaluating the prognostic usefulness of (123)I-mIBG scintigraphy for identifying subjects with heart failure who will experience a major adverse cardiac event. Subjects with NYHA class II and ...
Hsiao Yui-May YM Department of Industrial and Physical Pharmacy, Purdue University, West Lafayette, IN 47907, - - 2009
In locations that lack nearby cyclotron facilities for radionuclide production, generator-based (68)Ga radiopharmaceuticals might have clinical utility for positron emission tomography (PET) studies of myocardial perfusion and other physiological processes. The lipophilic and monocationic (67)Ga-labeled gallium chelates of five novel hexadentate bis(salicylaldimine) ligands the bis(salicylaldimine), bis(3-methoxysalicylaldimine), bis(4-methoxysalicylaldimine), bis(6-meth,oxysalicylaldimine), and bis(4,6-dimethoxysalicylaldimine) ...
Berbari R R INSERM U678, UPMC, F-75013 Paris France and Téécom ParisTech (ENST), CNRS UMR 5141, F-75013 Paris France. - - 2009
Evaluating myocardial viability is an important prognostic factor in the follow-up of infarctions. Delayed Enhancement magnetic resonance (DE-MR) imaging allows precise delineation of the infarct transmural extent. Visual interpretation is the most commonly used method to assess the myocardial infarction (MI) transmural extent. This study proposes to automate the segmentation ...
Spiridonidis Tryfon - - 2008
We report a case of thrombotic thrombocytopenic purpura (TTP) with cardiac involvement, imaged with Tc-99m depreotide. A 56-year-old man presented with fever, hematuria, and chest pain. Laboratory findings (angiopathic hemolytic anemia, thrombocytopenia, and uremia) were suggestive of TTP. Cardiac enzymes were elevated and diffuse left ventricular hypokinesis was demonstrated by ...
Baskot Branislav - - 2008
The aim of this study was to determine and localize culprit lesion by myocardial perfusion imaging (MPI) in cases of angiographically detected coronary narrowing >or= 75% of at least one coronary artery. MATERIAL AND METHODS: One hundred and thirty-two (132) patients with angiographically detected significant coronary narrowing (>or= 75% luminal ...
Georgoulias Panagiotis - - 2008
OBJECTIVE: Percutaneous transluminal coronary angioplasty is a well-established therapeutic method in selected patients with coronary artery disease. The aim of this study was to assess the incremental prognostic value of technetium-99m ((99m)Tc)-tetrofosmin myocardial gated-single- photon emission computed tomography (SPECT) in asymptomatic patients after coronary artery stenting. METHODS: A total of ...
Johansson Lena - - 2008
Both stress and rest imaging are usually performed to diagnose ischemia or infarction in the left ventricle. If the stress study is performed first and the images indicate normal findings, it might be unnecessary to perform the rest study. The current study determines whether nuclear medicine technologists can assess the ...
Goernig M - - 2009
The assessment of myocardial viability is a major diagnostic challenge in patients with coronary artery disease (CAD) after myocardial infarction. Novel threedimensional current density (CD) imaging algorithms use high-resolution magnetic field mapping to determine the electrical activity of myocardial segments at rest. We, for the first time, compared CD activity ...
Baldwa Sunil - - 2008
Viable, chronically dysfunctional myocardium with reduced resting flow (or hibernating myocardium) is an important prognostic factor in ischemic heart disease. Although thallium-201 imaging is frequently used to assess myocardial viability in patients with ischemic cardiomyopathy, there are limited data regarding its deposition in hibernating myocardium, and this data suggest that ...
Demirkol Mehmet Onur - - 2008
In this article, the role of nuclear medicine modalities in assessing myocardial viability and risk stratification in patients with advanced left ventricular (LV) dysfunction are reviewed. Diagnosis of reversible LV dysfunction in patients with heart failure is an important clinical issue. Patients with severe LV dysfunction who have viable myocardium ...
Ozben Beste - - 2008
With the rapid evolution of cardiovascular magnetic resonance imaging (MRI) techniques, cardiovascular MRI has become an important noninvasive diagnostic tool in cardiovascular disease. Cardiac MRI can provide high quality diagnostic information about cardiac and valvular function, coronary anatomy, coronary flow reserve and myocardial perfusion, myocardial viability, contractile reserve and cardiac ...
Meyer-Spradow Jennis - - 2008
Myocardial perfusion imaging with single photon emission computed tomography (SPECT) is an established method for the detection and evaluation of coronary artery disease (CAD). State-of-the-art SPECT scanners yield a large number of regional parameters of the left-ventricular myocardium (e.g., blood supply at rest and during stress, wall thickness, and wall ...
Santana Cesar A - - 2008
OBJECTIVES: This study was performed to determine the prognostic performance of quantitative PET tools in the stratification of patients with ischemic cardiomyopathy undergoing myocardial viability assessment. METHODS: We applied four different quantitative tools to 104 consecutive patients with coronary artery disease and previous myocardial infarction who had undergone rest Rb/gated ...
Matsumoto Naoya - - 2008
BACKGROUND: The prognostic value of ECG-gated rest 201Tl/stress 99mTc-tetrofosmin myocardial perfusion single-photon emission computed tomography for the prediction of acute coronary syndrome (ACS: myocardial infarction (MI) and unstable angina (UA)) and the implications of ejection fraction (EF) has not yet been defined in Japanese. METHODS AND RESULTS: The 1,895 patients ...
Lee In Ho - - 2009
OBJECTIVE: To evaluate the ability of MDCT to detect a nonviable myocardium in patients with myocardial infarction (MI). METHODS AND MATERIAL: This study included 17 patients with MI in the acute (n=13) or chronic stage (n=4). MDCT, SPECT, and F-18-FDG-PET were performed in 10 patients during the acute stage and ...
Candell-Riera Jaume - - 2008
INTRODUCTION AND OBJECTIVES: The objective of this study was to use low-dose dobutamine (LDD) gated single-photon emission computed tomography (SPECT) to evaluate segmental thickening of the left ventricle (LV) and its relationship with changes in ejection fraction (EF) and ventricular volumes in patients with ischemic cardiomyopathy. METHODS: This prospective multicenter ...
Nakae Ichiro - - 2008
OBJECTIVE: Studies have suggested that ischemia-induced diastolic dysfunction persists longer than systolic dysfunction. We examined whether global left ventricular (LV) diastolic function during stress testing assessed by 16-frame gated myocardial perfusion single-photon emission computed tomography (SPECT) is useful as an indicator of myocardial ischemia. METHODS: Thirty-nine patients underwent 16-frame technetium-99m ...
Godino Cosmo - - 2008
BACKGROUND: Inflammation appears to be important in the pathogenesis of acute myocardial infarction (AMI). METHODS AND RESULTS: Cardiac [18-F]-fluoro-deoxy-glucose (FDG) uptake by positron emission tomography/computed tomography (PET/CT)-scan was investigated in 12 fasting patients with first AMI (FAMI) single-vessel disease after successful primary percutaneous coronary intervention and at 9 weeks follow-up, ...
Kasamatsu Tomotaka - - 2008
BACKGROUND: Myocardial perfusion single-photon emission computed tomography (SPECT) has been used for risk stratification before non-cardiac surgery. However, few authors have used mathematical models for evaluating the likelihood of perioperative cardiac events. METHODS AND RESULTS: This retrospective cohort study collected data of 1,351 patients referred for SPECT before non-cardiac surgery. ...
Higuchi Takahiro - - 2008
Conventional myocardial perfusion PET tracers require onsite tracer production because of their short radioactive half-lives. To investigate the potential of a new (18)F-labeled pyridazinone analog ((18)F-BMS-747158-02), we characterized this tracer in a rat model of permanent and transient coronary occlusion using small-animal PET. METHODS: Myocardial (18)F-BMS-747158-02 distribution in healthy rats ...
Lertsburapa Kirkeith - - 2008
BACKGROUND: Whether left ventricular ejection fraction (EF) obtained by gated rubidium 82 positron emission tomography (PET) myocardial imaging can identify patients at risk for future cardiac events is unclear. METHODS AND RESULTS: Consecutive patients with known or suspected coronary artery disease who underwent dipyridamole stress gated Rb-82 PET imaging were ...
Akutsu Yasushi - - 2009
PURPOSE: Microcirculatory failure after reperfusion is clinically indicated to cause reperfusion injury whereas excessive intracellular calcium ion overload is experimentally proved as a key mechanism of reperfusion injury. We hypothesized that technetium-99m ((99m)Tc) pyrophosphate (Tc-PYP) uptake in injured but viable infarct-related myocardium with preserved myocardial perfusion after reperfusion estimated by ...
Corona Giovanni - - 2008
INTRODUCTION: The use of the penile peak systolic velocity (PSV) measured in the flaccid state during penile color Doppler ultrasound (PCDU) examination has been questioned without substantial evidence. AIM: To assess the validity of PSV measured in the flaccid state during PCDU, in patients consulting for erectile dysfunction (ED). METHODS: ...
Zhu Xiaoguang - - 2008
OBJECTIVE: The C2A domain of Synaptotagmin I is a molecular probe for the specific imaging of cell death. Here we test the hypothesis that the uptake of 99mTc-C2A in the acute phase of an infarction is associated with cardiac dysfunction in follow-ups. METHODS: The left coronary artery was occluded in ...
Kajimoto Yoshinori - - 2009
Both transcranial sonography (TCS) of the substantia nigra (SN) and metaiodobenzylguanidine (MIBG) myocardial scintigraphy have been determined to be useful for the diagnosis of Parkinson's disease (PD). In the present study, we performed both tests in 65 consecutive Japanese patients with idiopathic PD. In 30 PD patients (46.2%), the midbrain ...
Orlov Michael V - - 2008
PURPOSE: We prospectively determined whether preimplant myocardial perfusion imaging (MPI) predicts outcome with biventricular pacing (BiVP). METHODS: Single-photon emission computed tomography (SPECT) MPI, left ventricular (LV) volumes, ejection fraction (EF), 6-min hall walk (6MW) were assessed at baseline and at 4 months in 19 patients with ischemic cardiomyopathy undergoing BiVP. ...
Okada David R - - 2008
OBJECTIVE: To compare the myocardial kinetics of three (99m)technetium-labeled monocationic tracers [methoxy-isobutylisonitrile (MIBI), tetrofosmin, and Q12] in a model of ischemia-reperfusion (IR) to determine their abilities to assess myocardial viability. METHODS: Isolated perfused rat hearts (n = 30) were studied in control and IR groups for each tracer. IR hearts ...
Bax Jeroen J - - 2008
BACKGROUND: Disturbances of autonomic function after infarction are associated with both total mortality and sudden death. Although many imaging techniques for assessing the cardiac autonomic nervous system have been studied, the clinical usefulness of these techniques remains uncertain. This exploratory pilot study examined the relationship between abnormalities of ventricular sympathetic ...
Spinelli Antonella - - 2008
BACKGROUND: In patients with cardiac syndrome X (CSX) who present with refractory angina episodes, spinal cord stimulation (SCS) has beneficial effects. The mechanisms of SCS, however, remain speculative. We assessed the effects of SCS on cardiac sympathetic function in these patients. METHODS AND RESULTS: We studied 11 CSX patients treated ...
Gimelli Alessia - - 2008
We sought to compare the reliability and prognostic implications of left ventricular (LV) ejection fraction (EF) measurements obtained in routine clinical practice. We retrospectively selected from our clinical database a group of 422 patients with known or suspected ischemic heart disease, studied by two-dimensional echocardiography, gated single-photon emission computed tomography ...
Her Sung Ho - - 2008
BACKGROUND: The noninvasive differentiation of ischemic from nonischemic cardiomyopathy is clinically important. However, whether adenosine Tc-99m tetrofosmin SPECT can offer clear and accurate information was not known. The aim of this study is to investigate the usefulness of adenosine Tc-99m tetrofosmin SPECT in differentiation of ischemic from nonischemic etiology in ...
Gimelli Alessia - - 2008
BACKGROUND: In the absence of significant coronary stenoses, stress-induced myocardial perfusion abnormalities at gated single photon emission computed tomography (g-SPECT) are usually considered to be a 'false-positive' result. Our goal was to investigate how false-positive g-SPECT perfusion abnormalities relate to cardiovascular risk factors and whether they provide any prognostic information. ...
Cianciulli Tomás F - - 2008
BACKGROUND: Several methods are available for the assessment of coronary endothelial function, but there are no reports to date regarding the usefulness of cold pressor stress echocardiography (CPSE). OBJECTIVE: To assess regional systolic and diastolic left ventricular function using CPSE in patients with endothelial dysfunction. METHODS: We studied 24 patients, ...
Teragawa Hiroki - - 2008
BACKGROUND: Adenosine triphosphate stress thallium-201 single-photon emission computed tomography (ATP-SPECT) is useful for diagnosing coronary artery disease (CAD), although sometimes false positive results are observed. It has not been established whether a coronary spasm is responsible for the false positive findings during ATP-SPECT. HYPOTHESIS: We investigated whether coronary spasm is ...
Kanamaru Hiroshi - - 2009
Bland-White-Garland syndrome (BWG) is a rare disorder that includes abnormalities of the coronary arteries that cause severe myocardial ischemia or infarction in infancy. In this case report, we describe an infant with BWG evaluated by dual single photon emission computed tomography using thallium-201 and I-123 beta-methyl-p-iodophenyl-pentadecanoic acid before and after ...
Chan Jonathan - - 2008
AIMS: Transmural extent (TME) of myocardial scar, contractile reserve, and perfusion all predict improvement in regional myocardial function after coronary revascularization. We sought their association with regional remodelling after infarction. METHODS AND RESULTS: We studied 89 patients (age 62 +/- 10 years) with left ventricular (LV) dysfunction, at least 1 ...
Suzuki Yasuyuki - - 2008
In this study, we compared the diagnostic performance of the standard SPECT with motion-frozen (MF) myocardial perfusion SPECT (MPS) in obese patients. A total of 90 consecutive obese patients (body mass index, 30.1-46.8, average, 34.3 +/- 3.6; age, 63 +/- 12 y; 30% women) underwent standard supine rest (201)Tl/stress (99m)Tc ...
Sato Akira - - 2008
BACKGROUND: This study was designed to assess the influence of coronary endothelial function and the serial changes of dual myocardial single photon emission computed tomography (SPECT) imaging in transient left ventricular (LV) apical ballooning. METHODS AND RESULTS: We evaluated 35 consecutive patients (8 men and 27 women; mean age, 71 ...
Morishima Itsuro - - 2008
BACKGROUND: The Multicenter Automatic Defibrillator Implantation Trial II (MADIT-II) has shown that the prophylactic implantable cardiac defibrillator improves the survival rate of patients with prior myocardial infarction and advanced left ventricular (LV) dysfunction. However, a more accurate noninvasive predictor should be found to identify subgroups at high risk, one that ...
Nishimura Masato - - 2008
We prospectively evaluated if impaired myocardial fatty acid metabolism is involved in cardiac death after revascularization by percutaneous coronary artery intervention in dialysis patients. A cohort of hemodialysis patients was assessed by dual single-photon emission computed tomography using the radioiodinated fatty acid analogue BMIPP and radiolabeled thallium chloride. Tomography was ...
Nakajima Kenichi - - 2008
BACKGROUND: Prediction of left ventricular functional recovery is important after myocardial infarction. The impact of quantitative perfusion and motion analyses with gated single-photon emission computed tomography (SPECT) on predictive ability has not been clearly defined in multi-center studies. METHODS: A total of 252 patients with recent myocardial infarction (n = ...
Feola Mauro - - 2008
BACKGROUND: Clinical outcome can be predicted by metabolism-perfusion positron emission tomography (PET) in patients with severe ischaemic left ventricular dysfunction. This study determined whether the amount of viable or non-viable myocardium detected with a PET scan or clinical-functional parameters might predict cardiovascular events. METHODS: All patients had previous myocardial infarction ...
Kaya Eser - - 2008
BACKGROUND: Behçet's disease (BD) is a systemic multi-system vasculitis that can have a wide range of effects on the cardiovascular system. OBJECTIVE: To determine the existence of myocardial perfusion defects caused by coronary microvascular dysfunction in BD and to evaluate coronary arterial distribution and left ventricular systolic function by gated ...
Petretta Mario - - 2008
The quantitative assessment of coronary flow reserve (CFR) may be useful for the functional evaluation of coronary artery disease (CAD), allowing judgment of its severity, tracking of disease progression, and evaluation of the anti-ischemic efficacy of therapeutic strategies. Invasive techniques, such as intracoronary Doppler ultrasound and the pressure-derived method, which ...
Akhter Nasima - - 2008
PURPOSE: Gated single-photon emission computed tomography (SPECT) imaging of myocardium by (99m)Tc and (201)Tl is used extensively to measure quantitative cardiac functional parameters. However, factors affecting normal values for myocardial functional parameters and population-specific standards have not yet been established. The aim of the study was to determine the effect ...
Kaminek Milan - - 2008
BACKGROUND: The impact of different levels of tracer uptake on improvements of left-ventricular (LV) function was analyzed in patients treated by intracoronary bone marrow cell (BMC) transplantation. METHODS AND RESULTS: Thirty-one patients with irreversible damage after their first acute myocardial infarction (MI), as confirmed by sestamibi single-photon emission computed tomography ...
Matsuo Shinro - - 2008
BACKGROUND: In Japan, Diagnosis Procedure Combination (DPC) of hospitalization health-care costs has been introduced since 2004, and its introduction has been recently expanded also to general hospitals. In such situations, the role of nuclear cardiology as a gatekeeper for the diagnosis of ischemic heart disease is increasingly important. Thus, the ...
Muellerleile K - - 2008
Assessment of myocardial viability aims at differentiating between viable and non-viable myocardium. The proof of dysfunctional but viable myocardium is crucial to predict outcome of revascularization after acute (AMI) and chronic myocardial infarction (CMI). Cardiac magnetic resonance imaging (CMRI) offers different options to detect viable myocardium: Measurements of end-diastolic wall ...
Uchida Yasuto - - 2008
BACKGROUND: Although there are many reports on Ampulla Cardiomyopathy, its etiologic mechanisms are not well known. AIM: Etiology of Ampulla Cardiomyopathy was investigated by myocardial scintigraphy with various nuclear tracers. SUBJECTS AND METHODS: In nine patients with Ampulla Cardiomyopathy, myocardial scintigraphy was performed at acute, subacute and chronic phases. Total ...
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