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Ruzsics Balazs - - 2009
To evaluate the performance of dual-energy computed tomography (CT) for integrative imaging of the coronary artery morphology and the myocardial blood supply, 36 patients (15 women, mean age 57 +/- 11 years) with equivocal or incongruous single photon emission CT (SPECT) results were investigated by a single-contrast medium-enhanced, retrospectively electrocardiographic-gated ...
Bauner Kerstin U - - 2009
OBJECTIVE: The aim of our study was to show that spatial resolution can be improved without loss of diagnostic accuracy if a 3D inversion recovery gradient-recalled echo (GRE) sequence is used instead of a segmented inversion recovery GRE at 3 T for the assessment of myocardial infarction. SUBJECTS AND METHODS: ...
Ernande Laura - - 2009
BACKGROUND: Left ventricular (LV) remodeling after myocardial infarction (MI) occurs frequently despite successful percutaneaous coronary intervention (PCI) but cannot be predicted by simple clinical parameters. METHODS AND RESULTS: This prospective study tested the value of rest and low-dose dobutamine (LDD) Tc-99m-mibi gated-SPECT for early prediction of LV remodeling in patients ...
Lautamäki Riikka - - 2009
BACKGROUND: Hybrid positron emission tomography/computed tomography (PET-CT) allows for combination of PET perfusion/metabolism imaging with infarct detection by CT delayed contrast enhancement. We used this technique to obtain biomorphological insights into the interrelation between tissue damage, inflammation, and microvascular obstruction early after myocardial infarction. METHODS AND RESULTS: A porcine model ...
Cimarelli Sébastien - - 2010
Takotsubo cardiomyopathy (TTC) is a novel heart disease, mimicking acute myocardial infarction. The term "transient left ventricular dysfunction syndrome" (TLVDS) seems to be more appropriate since variant forms of TTC sparing apical segments (mid-ventricular ballooning syndrome (MVBS) and inverted TTC) have been described. Patho-physiological bases of TLVDS remain poorly understood ...
Abidov Aiden - - 2009
BACKGROUND: We have advocated the use of a 5-category "normal," "probably normal," "equivocal," "probably abnormal," and "definitely abnormal" approach to final interpretation of myocardial perfusion single-photon emission computed tomography (SPECT). The prognostic value of expressing levels of certainty compared with a dichotomous normal/abnormal classification or categories for summed stress scores ...
Carlsson Marcus - - 2009
OBJECTIVES: Our goal was to validate myocardium at risk on T2-weighted short tau inversion recovery (T2-STIR) cardiac magnetic resonance (CMR) over time, compared with that seen with perfusion single-photon emission computed tomography (SPECT) in patients with ST-segment elevation myocardial infarction, and to assess the amount of salvaged myocardium after 1 ...
Lavender Frances M - - 2009
BACKGROUND: Estimation of the left ventricular ejection fraction (LVEF) using myocardial perfusion imaging is increasingly used in the evaluation of coronary artery disease. This study aims to compare the effect of (i) two commercially available software packages: quantitative gated single-photon emission computed tomography (SPECT) (QGS) and 4DM-SPECT, and (ii) prereconstruction ...
Nekolla S G - - 2009
BACKGROUND: Positron-emission tomography (PET) tracers for myocardial perfusion are commonly labeled with short-lived isotopes that limit their widespread clinical use. 18F-BMS-747158-02 (18F-BMS) is a novel pyridaben derivative that was evaluated for assessment of myocardial perfusion by comparison with 13N-ammonia (13NH3) and with radioactive microspheres in a pig model. METHODS AND ...
Viljanen Antti P M - - 2009
Obesity is associated with increased fatty acid uptake in the myocardium, and this may have deleterious effects on cardiac function. The aim of this study was to evaluate how weight loss influences myocardial metabolism and cardiac work in obese adults. Thirty-four obese (mean body mass index 33.7 +/- 0.7 kg/m(2)) ...
Büther Florian - - 2009
Gating methods acquiring biosignals (such as electrocardiography [ECG] and respiration) during PET enable one to reduce motion effects that potentially lead to image blurring and artifacts. This study evaluated different cardiac and respiratory gating methods: one based on ECG signals for cardiac gating and video signals for respiratory gating; 2 ...
Rayan Mona Mostafa MM Ain Shams University, Cardiology Department, Cairo, Egypt. - - 2009
In the setting of coronary artery disease, two-thirds of LV dysfunction is not the result of irreversible scar, but rather caused by impairment in function and energy use of "still-viable" myocyte. The opportunity for improved function, if coronary blood flow is restored, is there which makes the identification of viable ...
Akutsu Yasushi - - 2009
We report a reperfusion injury after rotational coronary atherectomy (RA) in a 66-year-old man with coronary artery disease. Submaximal exercise with thallium-201 single photon emission computed tomography (SPECT) imaging before reperfusion showed partially reversible perfusion defects in the apex and reversible perfusion defects in the anteroseptal area. Thallium-201 and I-123 ...
Khorsand Aliasghar - - 2009
OBJECTIVES: The purpose of this study was to compare quantitative ECG-gated single-photon emission computed tomography (SPECT) (QGS) and model-based ECG-gated single-photon emission computed tomography (MBGS) for determination of end-diastolic cardiac volume (EDV), end-systolic cardiac volume (ESV), and left ventricular ejection fraction (LVEF). The accuracy of both methods was evaluated by ...
Gimelli Alessia - - 2009
The prognostic power of myocardial perfusion imaging in patients with ischemic heart disease (IHD) has been demonstrated since planar imaging. We aimed to investigate whether gated SPECT retains this value in current cardiology if compared with a complete diagnostic work-up and with more recent prognostic indicators. METHODS: We selected from ...
Baghdasarian Sarkis B - - 2009
BACKGROUND: Despite growing recognition of attenuation correction (AC) utilizing an external radiation source, prognostic studies using AC are lacking. METHODS: Consecutive patients (n = 419) who underwent stress Tc-99m sestamibi SPECT imaging with AC but without ECG-gating, due to arrhythmia, were followed for cardiac death or non-fatal myocardial infarction (MI). ...
Neizel Mirja - - 2009
BACKGROUND: In clinical routine, rapid infarct sizing techniques are warranted, as objective and precise infarct sizing is important for clinical decision-making. Accurate and objective measures of relative infarct size (rIS) using contrast-enhanced cardiac magnetic resonance (ceCMR) have been extensively demonstrated in experimental animals, but less in humans. The aim of ...
Mouden Mohamed - - 2009
Evaluation of: Gaemperli O, Schepis T, Valenta I et al.: Functionally relevant coronary artery disease: comparison of 64-section CT angiography with myocardial perfusion SPECT. Radiology 248(2), 414-423 (2008). Computed tomography coronary angiography (CTCA) is increasingly applied for noninvasive detection of coronary stenoses, but a major limitation of this method is ...
Abidov Aiden - - 2009
A 47-year-old woman with no history of CAD presented with an episode of left-sided atypical chest pain. Her work-up was negative for acute MI. She underwent a myocardial perfusion Tc-99m tetrofosmin SPECT study to rule out myocardial ischemia. The SPECT images revealed a small nonreversible mid-anteroseptal perfusion defect. For additional ...
Kang Won Jun - - 2009
Myocardial SPECT using (99m)Tc-sestamibi, (99m)Tc-tetrofosmin, (201)Thallium is widely used in nuclear cardiology. Left ventricular systolic wall thickening (SWT) by SPECT and regional maximal elastance (rE(max)) using arterial tonometry were compared. rE(max) was calculated from time-pressure and time-volume curves. In normal heart, improvement of SWT was 4.1+/-11%, while 6.0+/-16% in dilated ...
Momose Mitsuru - - 2009
PURPOSE: The J-ACCESS [Japanese investigation of prognosis based on gated single photon emission computed tomography (SPECT)] study found that quantitative gated myocardial SPECT (QGS) is valuable for predicting the prognosis of Japanese patients with known or suspected ischaemic heart disease. The present study evaluates the incremental prognostic value of myocardial ...
Kisrieva-Ware Zulfia - - 2009
The goal of this study was to test whether myocardial triglyceride (TG) turnover including oxidation of TG-derived fatty acids (FA) could be assessed with PET and (11)C-palmitate. A total of 26 dogs were studied fasted (FAST), during Intralipid infusion (IL), during a hyperinsulinemic-euglycemic clamp without (HIEG), or with Intralipid infusion ...
Nakajima Kenichi - - 2009
We aimed to develop a Japanese normal database for specific acquisition conditions, to compare US and Japanese normal populations, and to examine effects of camera rotation angle range on the normal limits. Stress-rest (99m)Tc myocardial perfusion databases for 360 degrees (Jp360) and 180 degrees (Jp180) acquisitions were created by the ...
Lorincz István - - 2009
BACKGROUND: Data about biochemical abnormalities (catecholamines) during vasovagal syncope (VVS) are available, but adrenergic myocardial structural damage may be hypothesized as well. AIM: To study the global and regional adrenergic myocardial innervations in patients with VVS that was shown by head-up tilt table testing. PATIENTS AND METHODS: Fifteen adult patients ...
Perrone-Filardi Pasquale - - 2009
The prognostic role of rest-redistribution 201-Thallium imaging has not been extensively investigated in patients with left ventricular ischemic dysfunction. OBJECTIVE: The aim of this study was to evaluate the ability of rest-redistribution 201-Thallium single photon emission computed tomography to predict cardiac death and occurrence of acute myocardial infarction in patients ...
Peix Amalia A Institute of Cardiology, La Habana, Cuba. - - 2009
Microvascular disease is proposed as a cause of segmental myocardial blood flow abnormalities and heterogeneous myocardial perfusion in cardiac syndrome X. To assess if myocardial ischemia can be evidenced through both perfusion abnormalities and poststress left ventricular ejection fraction (LVEF) reduction by gated single photon emission tomography (SPECT) myocardial scintigraphy ...
Di Monaco A - - 2009
OBJECTIVE: To assess whether abnormalities in cardiac uptake of (123)I-metaiodobenzylguanidine (MIBG) correlate with coronary microvascular dysfunction in patients with cardiac syndrome X (CSX). SETTING: University hospital. PATIENTS: 29 patients (aged 59 (SD 7) years, 11 men) with typical CSX and a matched group of 20 healthy subjects (aged 56 (7) ...
Soneson Helen - - 2009
This study describes and validates a new method for automatic segmentation of left ventricular mass (LVM) in myocardial perfusion SPECT (MPS) images. This is important for estimating the size of a perfusion defect as percentage of the left ventricle. METHODS: A total of 101 patients with known or suspected coronary ...
Biswas Shankar Kumar - - 2010
BACKGROUND: Myocardial fatty acid metabolic imaging with beta-methyl iodophenyl pentadecanoic acid (BMIPP) and perfusion imaging with tetrofosmin (TF) combined can predict post ischemic salvageable myocardium and persistent left ventricular (LV) dysfunction. This study was designed for the first time to assess systolic, diastolic and global LV dysfunction considering BMIPP and ...
Cianciulli Tomás F - - 2009
BACKGROUND: Apical hypertrophy cardiomyopathy (ACM) is a rare condition characterized by asymmetric myocardial hypertrophy of the apex of the left ventricle. When two-dimensional echocardiography is limited by a poor acoustic window, patients are often referred for MRI. Our hypothesis is that a cheaper and more widely available diagnostic modality like ...
Pavlovic Smiljana V - - 2009
OBJECTIVE: Optimal treatment for chronic total occlusion (CTO) in the infarct-related coronary artery is not clear. Our aim was to assess myocardial perfusion, left ventricular ejection fraction (EF), and left ventricular size using gated single-photon emission computed tomography (SPECT) myocardial perfusion imaging with 99mTc-methoxy-isobutyl-isonitrile in patients with CTO before and ...
Soman Prem - - 2009
OBJECTIVE: The IMAGING in Heart Failure study was a prospective, multi-national trial designed to explore the role of single-photon emission computed tomographic (SPECT) myocardial perfusion imaging (MPI) as an initial investigative strategy in patients hospitalized with new-onset heart failure. METHODS: We recruited 201 patients (age 65.3 +/- 14.5 years, 43% ...
Gudmundsson Petri - - 2009
AIMS: Real-time perfusion (RTP) adenosine stress echocardiography (ASE) can be used to visually evaluate myocardial ischaemia. The RTP power modulation technique angio-mode (AM), provides images for off-line perfusion quantification using Qontrast software, generating values of peak signal intensity (A), myocardial blood flow velocity (beta) and myocardial blood flow (Axbeta). By ...
Gudmundsson Petri - - 2009
BACKGROUND: Real-time perfusion (RTP) contrast echocardiography can be used during adenosine stress echocardiography (ASE) to evaluate myocardial ischemia. We compared two different types of RTP power modulation techniques, angiomode (AM) and high-resolution grayscale (HR), with 99mTc-tetrofosmin single-photon emission computed tomography (SPECT) for the detection of myocardial ischemia. METHODS: Patients with ...
Martins Elisabete - - 2009
The pathological significance of myocardial adrenergic activity in patients with heart failure is well documented. No previous study has assessed the usefulness of I123-metaiodobenzylguanidine (123I-MIBG) cardiac uptake imaging for the evaluation of familial dilated cardiomyopathy (DCM). OBJECTIVE: To evaluate cardiac adrenergic activity, using 123I-MIBG cardiac uptake imaging, in members of ...
America Yves G C J - - 2009
BACKGROUND: The aim of this study was to assess the prognostic value of technetium-99m tetrofosmin gated SPECT imaging in women using quantitative gated single photon emission computed tomography (SPECT) imaging. METHODS: We followed 453 consecutive female patients. Average follow-up was 1.33 years (max. 2.55). Hard endpoints were cardiac death, acute ...
Hoffmann Rainer - - 2009
BACKGROUND: Myocardial deformation imaging and contrast-enhanced cardiac magnetic resonance imaging (ceMRI) have been used to define myocardial viability in ischemic left ventricular dysfunction. This study evaluated the incremental predictive value of an integrated analysis of function and tissue structure for functional improvement after revascularization therapy. METHODS: In 59 patients with ...
Stirrup James - - 2009
Many tests are available for the investigation of patients with heart failure. The identification of the underlying aetiology of ventricular dysfunction is crucial as early treatment may limit or even reverse myocardial abnormalities. This article describes cardiac radionuclide imaging techniques and their applications in ischaemic ventricular dysfunction. Evidence for the ...
Ishii Shirou - - 2009
OBJECTIVE: We investigated the ability to discriminate between Alzheimer's disease (AD) and vascular dementia (VaD), and between AD and non-dementia using the program "easy Z score imaging system" (eZIS) developed by Matsuda et al., for the diagnosis of very early AD. METHODS: Of 201 patients, we investigated 12 patients with ...
Evangelista Laura - - 2009
BACKGROUND: We evaluated the incremental prognostic value of viability assessment by nitrate single-photon emission computed tomography (SPECT) in patients with ischemic left ventricular (LV) dysfunction. METHODS AND RESULTS: One hundred and sixty-four patients with previous myocardial infarction and LV dysfunction (ejection fraction 29% +/- 15%) underwent two Tc-99m sestamibi SPECT ...
Glaveckaite Sigita - - 2009
Chronic ischemic left ventricular dysfunction is present in number of clinical syndromes in which myocardial revascularization results in an improvement of left ventricular function, patients' functional class, and their survival. Coronary arteriography is of limited value in diagnosis of viability. Noninvasive testing, traditionally nuclear imaging, stress echocardiography and (stress) electrocardiography ...
Crean Andrew - - 2009
Patients with heart failure and ischaemic heart disease may obtain benefit from revascularisation if viable dysfunctional myocardium is present. Such patients have an increased operative risk, so it is important to ensure that viability is correctly identified. In this study, we have compared the utility of 3 imaging modalities to ...
Greenwood John P - - 2009
Several investigations are currently available to establish the diagnosis of coronary heart disease (CHD). Of these, cardiovascular magnetic resonance (CMR) offers the greatest information from a single test, allowing the assessment of myocardial function, perfusion, viability and coronary artery anatomy. However, data from large scale studies that prospectively evaluate the ...
Jacobson Arnold F AF GE Healthcare, 101 Carnegie Center, Princeton, NJ 08540, USA. - - 2009
ADMIRE-HF (AdreView Myocardial Imaging for Risk Evaluation in Heart Failure) consists of two identical prospective open-label, multicenter, phase 3 studies (MBG311 and MBG312) evaluating the prognostic usefulness of (123)I-mIBG scintigraphy for identifying subjects with heart failure who will experience a major adverse cardiac event. Subjects with NYHA class II and ...
Hsiao Yui-May YM Department of Industrial and Physical Pharmacy, Purdue University, West Lafayette, IN 47907, - - 2009
In locations that lack nearby cyclotron facilities for radionuclide production, generator-based (68)Ga radiopharmaceuticals might have clinical utility for positron emission tomography (PET) studies of myocardial perfusion and other physiological processes. The lipophilic and monocationic (67)Ga-labeled gallium chelates of five novel hexadentate bis(salicylaldimine) ligands the bis(salicylaldimine), bis(3-methoxysalicylaldimine), bis(4-methoxysalicylaldimine), bis(6-meth,oxysalicylaldimine), and bis(4,6-dimethoxysalicylaldimine) ...
Berbari R R INSERM U678, UPMC, F-75013 Paris France and Téécom ParisTech (ENST), CNRS UMR 5141, F-75013 Paris France. - - 2009
Evaluating myocardial viability is an important prognostic factor in the follow-up of infarctions. Delayed Enhancement magnetic resonance (DE-MR) imaging allows precise delineation of the infarct transmural extent. Visual interpretation is the most commonly used method to assess the myocardial infarction (MI) transmural extent. This study proposes to automate the segmentation ...
Spiridonidis Tryfon - - 2008
We report a case of thrombotic thrombocytopenic purpura (TTP) with cardiac involvement, imaged with Tc-99m depreotide. A 56-year-old man presented with fever, hematuria, and chest pain. Laboratory findings (angiopathic hemolytic anemia, thrombocytopenia, and uremia) were suggestive of TTP. Cardiac enzymes were elevated and diffuse left ventricular hypokinesis was demonstrated by ...
Baskot Branislav - - 2008
The aim of this study was to determine and localize culprit lesion by myocardial perfusion imaging (MPI) in cases of angiographically detected coronary narrowing >or= 75% of at least one coronary artery. MATERIAL AND METHODS: One hundred and thirty-two (132) patients with angiographically detected significant coronary narrowing (>or= 75% luminal ...
Georgoulias Panagiotis - - 2008
OBJECTIVE: Percutaneous transluminal coronary angioplasty is a well-established therapeutic method in selected patients with coronary artery disease. The aim of this study was to assess the incremental prognostic value of technetium-99m ((99m)Tc)-tetrofosmin myocardial gated-single- photon emission computed tomography (SPECT) in asymptomatic patients after coronary artery stenting. METHODS: A total of ...
Johansson Lena - - 2008
Both stress and rest imaging are usually performed to diagnose ischemia or infarction in the left ventricle. If the stress study is performed first and the images indicate normal findings, it might be unnecessary to perform the rest study. The current study determines whether nuclear medicine technologists can assess the ...
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