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Ishikawa Kiyotake K Icahn School of Medicine at Mount Sinai - - 2014
Background: Large animal studies are an important step towards clinical translation of novel therapeutic approaches. We aimed to establish an ischemic heart failure (HF) model with a larger myocardial infarction (MI) relative to previous studies, and characterize the functional and structural features of this model. Methods: An MI was induced ...
Madsen Sarah K SK USC Imaging Genetics Center, Department of Neurology, Keck School of Medicine of USC, Los Angeles, CA, - - 2014
Dynamic changes in the brain's lateral ventricles on magnetic resonance imaging are powerful biomarkers of disease progression in mild cognitive impairment (MCI) and Alzheimer's disease (AD). Ventricular measures can represent accumulation of diffuse brain atrophy with very high effect sizes. Despite having no direct role in cognition, ventricular expansion co-occurs ...
Hor Kan N KN Nationwide Children's Hospital, Columbus, OH, - - 2014
The aim of this study is to determine the contribution of strain ε cc in mid left ventricular (LV) segments to the reduction of composite LV circumferential ε cc in assess severity of duchenne muscular dystrophy (DMD) heart disease as assessed by cardiac magnetic resonance imaging (CMR). DMD patients and ...
Kappetein A Pieter AP Department of Cardiothoracic Surgery, Thoraxcenter Erasmus MC, PO Box 2040, Rotterdam 3000 CA, The Netherlands. Electronic address: - - 2014
Coronary artery bypass grafting (CAGB) is superior to percutaneous coronary intervention (PCI) in reducing mortality in certain patients and improving the composite end points of angina, recurrent myocardial infarction, and repeat revascularization procedures. However, CABG is associated with a higher perioperative stroke risk. For patients with less complex disease or ...
Aronson Doron D Department of Cardiology, Rambam Medical Center, Technion, Israel Institute of Technology, P.O.B 9602, Haifa 31096, Israel. Electronic address: - - 2014
Diabetes mellitus (DM) is a major risk factor for cardiovascular disease. Near-normal glycemic control does not reduce cardiovascular events. For many patients with 1- or 2-vessel coronary artery disease, there is little benefit from any revascularization procedure over optimal medical therapy. For multivessel coronary disease, randomized trials demonstrated the superiority ...
Komamura Kazuo K Kazuo Komamura, Miho Fukui, Toshihiro Iwasaku, Shinichi Hirotani, Tohru Masuyama, Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya 663-8501, - - 2014
In 1990, takotsubo cardiomyopathy (TCM) was first discovered and reported by a Japanese cardiovascular specialist. Since then, this heart disease has gained worldwide acceptance as an independent disease entity. TCM is an important entity that differs from acute myocardial infarction. It occurs more often in postmenopausal elderly women, is characterized ...
Sechi Annalisa - - 2014
Cardiovascular magnetic resonance (CMR) with late gadolinium enhancement (LGE) imaging is increasingly used to assess myocardial involvement in patients with Fabry disease, an X linked lipid storage disorder. However, it is often proposed as an optional tool. A different cardiomyopathic disease progression between male and female patients was hypothesised in ...
Buszman Pawel E PE American Heart of Poland, Center for Cardiovascular Research and Development, Katowice, - - 2014
The optimal revascularization strategy in patients with complex coronary artery disease and non-ST-segment elevation acute coronary syndromes is undetermined. In this multicenter, prospective registry, 4,566 patients with non-ST-segment elevation myocardial infarctions, unstable angina, and multivessel coronary disease, including left main disease, were enrolled. After angiography, 3,033 patients were selected for ...
Cermakova Pavla P Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division for Neurogeriatrics, Huddinge, Sweden; International Clinical Research Center, St. Anne's University Hospital, Brno, Czech - - 2014
It has recently been proposed that heart failure is a risk factor for Alzheimer's disease. Decreased cerebral blood flow and neurohormonal activation due to heart failure may contribute to the dysfunction of the neurovascular unit and cause an energy crisis in neurons. This leads to the impaired clearance of amyloid ...
Ungerleider Jessica L JL Department of Bioengineering, Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, California, - - 2014
Recently, injectable biomaterial-based therapies for cardiovascular disease have been gaining attention, because they have shown therapeutic potential in preclinical models for myocardial infarction (MI) and peripheral artery disease (PAD). Naturally derived (e.g., alginate, hyaluronic acid, collagen, or extracellular matrix-based) or synthetic (e.g., peptide or polymer-based) materials can enhance stem cell ...
Mittal Mayank - - 2014
3-Hydroxy-3-methyl-glutarylCoA reductase inhibitors, or statins, are a mainstay in the treatment of patients with established coronary artery disease (CAD) because of their proven efficacy in reducing cardiovascular death, myocardial infarction, and coronary revascularization procedures in this patient population. Statin therapy has also proven successful in the primary prevention of CAD. ...
Wu Hui H From the *Department of Neurosurgery, and †Department of Nuclear Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, - - 2014
Moyamoya disease patients with subarachnoid hemorrhage and cerebral infarction are rare, especially when the subarachnoid hemorrhage is nonaneurysmal. Here, we present one 48-year-old male patient with moyamoya disease identified with digital subtraction angiography. His initial symptoms are associated with increased intracranial pressure. Subsequent computed tomography demonstrated subarachnoid hemorrhage and cerebral ...
Morales-Villegas E E MAC-CMQ Hospital, Aguascalientes, Mexico, República del Perú 102-201-C. Las Américas. Aguascalientes, México. 20230. - - 2014
The profile of ischemic heart disease by coronary atherosclerosis has been developed based on clinical, paraclinical and angiographic grounds inherent to the male gender. A man in his 40s - 50s with "classical" cardiovascular risk factors, angina pectoris and hemodynamically significant myocardial ischemia associated with angiographic stenosis (≥ 50% endovascular ...
Kelion Andrew D AD Consultant Cardiologist in the Cardiology Department, John Radcliffe Hospital, Headington, Oxford OX3 - - 2014
Myocardial perfusion scintigraphy is the longest established of the functional imaging investigations for patients with known or suspected coronary artery disease. This article describes recent technical and clinical advances that are ensuring that the technique remains relevant some 40 years after its first introduction.
Di Gioia Giuseppe G Cardiovascular Center Aalst, OLV Hospital, Aalst, - - 2014
In this article, we provide very illustrative images obtained with optical coherence tomography (OCT) of a patient presenting with ST-elevation myocardial infarction and multivessel disease. These patients are referred to the catheterization laboratory without performing any prior noninvasive imaging. This leads very often to diagnostic dilemmas with difficult solutions. Coronary ...
Backshall James J 1Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, United Kingdom 2Institute for Ageing and Health, Newcastle University, United Kingdom 3 Cardiothoracic Centre, Freeman Hospital, Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle-upon-Tyne, United - - 2014
Cardiovascular diseases remain the leading cause of death in the western world despite advances in therapeutics and interventions. The prescription of physical activity is a key component of cardiac rehabilitation following myocardial infarction. This review aims to outline the impact of physical activity in particular patient cohorts with coronary artery ...
Kloos Wanda W Department of Cardiology and Angiology, University Hospital Heidelberg, - - 2014
Peripheral artery disease (PAD) is a marker disease for generalized atherosclerosis and represents one of the worldÂ’s major causes of morbidity and mortality. Many studies have tried to gain insight into the molecular mechanisms involved in PAD onset, progression and prognosis. In the last decade, small non-coding RNAs, termed miRNAs, ...
Thissen Sam S Department of Neurology, Atrium Medical Centre, Heerlen, The - - 2014
The pathophysiology of migraine with aura is thought to be related to cortical spreading depression and cortical hypersensitivity, in which inhibitory interneurons may play a role. Persistent migraine aura (PMA) without infarction is defined as auras that last longer than 1 week in the absence of infarction. We describe a ...
Owen Meredith Kohr MK From the Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill (M.K.O.); and Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis (J.N.N., D.J.S., A.M.C., A.G.G., - - 2014
Coronary perivascular adipose tissue is a naturally occurring adipose tissue depot that normally surrounds the major coronary arteries on the surface of the heart. Although originally thought to promote vascular health and integrity, there is a growing body of evidence to support that coronary perivascular adipose tissue displays a distinct ...
Andrade Jason J From Department of Medicine and Research Center, Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada (J.A., P.K., S.N.); Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada (J.A.); and Faculty of Medicine, Institute of Pharmacology, University Duisburg-Essen, Essen, Germany - - 2014
Atrial fibrillation (AF) is the most common arrhythmia (estimated lifetime risk, 22%-26%). The aim of this article is to review the clinical epidemiological features of AF and to relate them to underlying mechanisms. Long-established risk factors for AF include aging, male sex, hypertension, valve disease, left ventricular dysfunction, obesity, and ...
Kounis Nicholas G NG 1Medical Sciences, Patras Highest Institute of Education and Technology, Patras, - - 2014
Inflammation is a key feature of atherosclerosis and its clinical manifestations. The leukocyte count has emerged as a marker of inflammation that is widely available in clinical practice. Since inflammation plays a key role in atherosclerosis and its end results, discovering new biomarkers of inflammation becomes important in order to ...
Ostergaard Leif L Department of Neuroradiology, Aarhus University Hospital, Building 10G, Nørrebrogade 44, 8000, Aarhus C, Denmark, - - 2014
Ischemic heart disease (IHD) is characterized by an imbalance between oxygen supply and demand, most frequently caused by coronary artery disease (CAD) that reduces myocardial perfusion. In some patients, IHD is ascribed to microvascular dysfunction (MVD): microcirculatory disturbances that reduce myocardial perfusion at the level of myocardial pre-arterioles and arterioles. ...
Matsushita Kazuki K Department of Cardiology, Tenri Hospital, 200, Mishima-cho, Tenri, Nara, - - 2014
The number of adult patients with coronary artery disease caused by Kawasaki disease (KD) is gradually increasing, but some patients drop out of clinical follow-up. However, careful, long-term follow-up and establishment of an optimal treatment strategy are needed in these patients, as well as cooperation between pediatric and adult cardiologists. ...
Radico Francesco F Institute of Cardiology and Center of Excellence on Aging, "G. d'Annunzio" University, Chieti, - - 2014
Angina and myocardial ischemia without obstructive coronary artery disease are common clinical findings, often neglected for the assumption of a good prognosis. Most often, such patients are neither further investigated nor offered specific treatment beyond reassurance. However, the absence of significant coronary stenoses on angiography does not necessarily imply a ...
Lala Anuradha A Division of Cardiology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA; Division of Cardiology, Department of Medicine, New York University School of Medicine, New York, NY, - - 2014
Enhanced survival following acute myocardial infarction and the declining prevalence of hypertension and valvular heart disease as contributors to incident heart failure (HF) have fueled the emergence of coronary artery disease (CAD) as the primary risk factor for HF development. Despite the acknowledged role of CAD in the development of ...
De Luca Giuseppe G Division of Cardiology, "Maggiore della Carità" Hospital, Eastern Piedmont University, Novara, Italy. Electronic address: - - 2014
Although primary angioplasty achieves Thrombolysis In Myocardial Infarction (TIMI) 3 flow in most patients with ST-elevation myocardial infarction, epicardial recanalization does not guarantee optimal perfusion in a large proportion of patients. Multivessel disease has been demonstrated to be associated with impaired survival, however its impact on infarct size has not ...
Modesto Karen K Zena and Michael A. Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, - - 2014
Cardiomyopathies are a heterogeneous group of diseases that can be phenotypically recognized by specific patterns of ventricular morphology and function. The authors summarize recent clinical observations that mechanistically link the multidirectional components of left ventricular (LV) deformation with morphological phenotypes of cardiomyopathies for offering key insights into the transmural heterogeneity ...
Montagnana Martina M Laboratory of Clinical Chemistry and Hematology, University of Verona, Verona, Italy. Electronic address: - - 2014
Calprotectin, also known as S100A8/A9 complex, is currently considered as a valid biomarker for diagnosis, follow-up and therapeutic monitoring of inflammatory bowel diseases. The attractive evidence that this protein may be actively produced and released by leukocytes (especially neutrophils) and by nonmyeloid cardiovascular cell types has paved the way to ...
Stöllberger Claudia C Hospital Rudolf Foundation, Vienna, - - 2014
A 55-year-old Caucasian male with coronary heart disease was admitted because of dyspnea for 4 weeks. Echocardiography showed a dilated left ventricle with an ejection fraction of 34% and apical left ventricular hypertrabeculation/noncompaction with an apical thrombus. Neurologic examination revealed positional tremor and generally reduced tendon reflexes. During 8 weeks, ...
Schelbert Erik B EB Heart & Vascular Institute Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Electronic address: - - 2014
New therapeutic targets, agents, and strategies are needed to prevent and treat heart failure (HF) after a decade of failed research efforts to improve long term patient outcomes, especially in patients following hospitalization for heart failure (HHF). Conceptually, an accurate assessment of left ventricular (LV) structure is an essential step ...
Stender Stefan S Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospitals and Faculty of Health and Medical Sciences, University of Copenhagen, - - 2014
To test the hypothesis that genetic variation in ABCG5/8, the transporter responsible for intestinal and hepatobiliary cholesterol efflux, might simultaneously influence plasma and biliary cholesterol levels, and hence risk of myocardial infarction(MI) and gallstone disease in opposite directions. High plasma levels of low-density lipoprotein(LDL) cholesterol are a causal risk factor ...
Rosenberg Karen K Karen - - 2014
No evidence that they prevent cognitive decline or cardiovascular events after myocardial infarction.
Kassimis George - - 2014
Randomized trials comparing multi-vessel percutaneous coronary intervention to coronary artery bypass grafting (CABG) have demonstrated the long-term superiority of CABG in diabetic patients. Benefits include improved survival, fewer recurrent myocardial infarctions and a lower risk of the need for repeat intervention. The focus of this review article is to review ...
Mirza Sumbul Javed SJ Department of Cardiology, Rashid Hospital, Dubai Health Authority, Dubai, United Arab - - 2014
Kawasaki disease usually affects infants and young children. It often goes unrecognized in adults due to varying symptoms and lack of definite diagnostic criteria. To describe the potential for acute myocardial infarction as a complication of antecedent Kawasaki Disease (KD). We describe a case of a 19-year-old man who presented to ...
Zhu Guo-Fu GF Department of Cardiology, Kunming General Hospital of Chengdu Military Area, Yunnan, - - 2014
This study aimed to investigate the association between microRNA-155 (miR-155) and the severity and extent of coronary stenotic lesions. We measured the miR-155 expression by real-time PCR in 110 consecutive patients undergoing coronary angiography for suspected coronary artery disease. The severity and extent of coronary stenotic lesions were evaluated on ...
Petersen Christina Bjørk - - 2014
Evidence suggests that sitting time is adversely associated with health risks. However, previous epidemiological studies have mainly addressed mortality whereas little is known of the risk of coronary heart disease. This study aimed to investigate total sitting time and risk of myocardial infarction, coronary heart disease incidence and all-cause mortality. ...
Sakurai-Komada Naomi N Center for Medical Sciences, School of Health Sciences, Ibaraki Prefectural University of Health Sciences, Ami, Ibaraki, - - 2014
Chlamydophila pneumoniae infection is considered a risk factor for atherosclerosis and coronary heart disease in western countries. However, evidence of it being a risk for Japanese is very limited because of a lower risk of coronary heart disease than for western people. The aim of this study was to examine ...
Mavrogeni Sophie S Onassis Cardiac Surgery Center, Athens, Greece. Electronic address: - - 2014
CMR, a non-invasive, non-radiating technique can detect myocardial oedema and fibrosis. CMR imaging, using T2-weighted and T1-weighted gadolinium enhanced images, has been successfully used in Cardiology to detect myocarditis, myocardial infarction and various cardiomyopathies. Transmitting this experience from Cardiology into Rheumatology may be of important value because: (a) heart involvement ...
Demyanets Svitlana S Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria; Department of Laboratory Medicine, Medical University of Vienna, Vienna, - - 2014
ST2 is a receptor for interleukin (IL)-33. We investigated an association of soluble ST2 (sST2) and IL-33 serum levels with different clinical stages of coronary artery disease. We assessed the predictive value of sST2 and IL-33 in patients with stable angina, non-ST elevation myocardial infarction (NSTEMI) and ST elevation myocardial ...
De Mello Walmor C WC School of Medicine, University of Puerto Rico Medical Sciences Campus , San Juan, PR , - - 2014
Evidence for the potential role of organ specific cardiovascular renin-angiotensin systems (RAS) has been demonstrated experimentally and clinically with respect to certain cardiovascular and renal diseases. These findings have been supported by studies involving pharmacological inhibition during ischemic heart disease, myocardial infarction, cardiac failure; hypertension associated with left ventricular ischemia, ...
Mishra Rakesh K RK Department of Medicine, University of California, San Francisco, California (R.K.M., A.L.B., R.J., M.A.W.) San Francisco Veterans Affairs Medical Center, San Francisco, California (R.K.M., M.R., - - 2014
Brain-type natriuretic peptide (BNP) and the amino-terminal fragment of its prohormone (NT-proBNP) are known predictors of cardiovascular outcomes in patients with coronary heart disease; however, the relative prognostic value of these 2 biomarkers for secondary events remains unclear. In 983 participants with stable coronary heart disease, we evaluated the association ...
Franczyk-Skóra Beata B Department of Nephrology, Hypertension and Family Medicine, WAM University Hospital of Lodz, - - 2013
Renal dysfunction is frequent in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS). Chronic kidney disease (CKD) is associated with very poor prognosis and is an independent predictor of early and late mortality and major bleeding in patients with NSTE-ACS. Patients with NSTE-ACS and CKD are still rarely treated according ...
Goyal Brij Mohan BM DM Cardiology Fellow, SMS Medical College, Jaipur, India. Electronic address: - - 2014
B-type natriuretic peptide has been used as a biological marker for prognosis in patients with acute coronary syndrome (ACS). However, a relation between the quantity of BNP levels and the severity of coronary artery disease has not been systematically evaluated. 197 patients with ACS without ST elevation with normal LV ...
Scimia Maria C MC Temple University, Translational Medicine/Pharmacology , 3500 N. Broad Street, Philadelphia, 19140 , USA - - 2013
Introduction: Cardiovascular gene therapy is the third most popular application for gene therapy, representing 8.4% of all gene therapy trials as reported in 2012 estimates. Gene therapy in cardiovascular disease is aiming to treat heart failure from ischemic and non-ischemic causes, peripheral artery disease, venous ulcer, pulmonary hypertension, atherosclerosis and ...
Comarmond Cloé C Department of Internal Medicine 2, Centre de Référence des Maladies Autoimmunes Rares, Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier Pitié Salpétrière, Université Pierre et Marie Curie, Paris, - - 2013
Takayasu arteritis (TA) may affect myocardium and cause coronary stenosis. The aim of this study was to assess the prevalence and pattern of myocardial disease in patients with TA, using late gadolinium enhancement (LGE) of cardiac magnetic resonance imaging (CMRI). Twenty-seven consecutive patients with TA and 80 age- and gender-matched ...
Kelshiker Mihir A - - 2013
A significant clinical problem is patients presenting with exercise-limiting dyspnoea, sometimes with associated chest pain, in the absence of detectable left ventricular (LV) systolic dysfunction, coronary artery disease, or lung disease. Often the patients are older, female, and have isolated basal septal hypertrophy (BSH), frequently on a background of mild ...
Lobo R - - 2013
Critical limb ischemia is the most severe manifestation of chronic peripheral artery disease (PAD). The goal of medical care is to provide symptomatic relief in patients who are unsuitable for percutaneous or surgical revascularization and to reduce systemic cardiovascular risk. PAD is a common manifestation of systemic atherosclerosis and is ...
Fares Hassan - - 2013
The electrocardiogram is the mainstay approach for diagnosing a myocardial infarction (MI). The diagnosis of an old MI and the identification of myocardial scar via the electrocardiogram are difficult because there are no other specific signs for a non-Q-wave MI. In this article, we will review the fragmented QRS and ...
Alfonso Fernando - - 2013
Tako-Tsubo cardiomyopathy is an entity of unknown etiology characterized by transient apical dyskinesia in patients with angiographically normal coronary arteries. However, atypical forms of Tako-Tsubo cardiomyopathy may also occur, affecting other myocardial segments. Optical coherence tomography has a unique resolution and may detect angiographically silent atherosclerotic coronary artery disease. In ...
Parikh P B PB Division of Cardiology, Department of Medicine Columbia University Medical Center/New YorkPresbyterian Hospital, New York, NY, USA - - - 2013
Optimal management of multivessel disease (MVD) is a complex medical decision with significant prognostic implications. Despite the advent of clinical and angiographic scores to aid with treatment delineation, therapy for MVD must be individualized for each patient and his/her clinical presentation. Particularly among patients with MVD, the selection of coronary ...
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