Search Results
Results 401 - 450 of 1550
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Newman Robert J - - 2008
PURPOSE: Exercise stress testing (EST) is a screening test for coronary artery disease. Previous studies from the cardiology literature show an overall sensitivity of 67% and specificity of 72% with variable predictive values depending on pretest probability. The purpose of the current study was to evaluate the predictive value of ...
Ostergren Jan J Department of Medicine, Karolinska University Hospital Solna, Stockholm, Sweden. - - 2008
To compare the effects of two antihypertensive treatment strategies for the prevention of coronary heart disease and other cardiovascular events in the large subpopulation (n=5137) with diabetes mellitus in the blood pressure-lowering arm of the Anglo-Scandinavian Cardiac Outcomes Trial. Patients had either untreated hypertension or treated hypertension. For those with ...
Schmidinger Manuela - - 2008
PURPOSE: Sunitinib and sorafenib are tyrosine kinase inhibitors (TKIs) that have considerable efficacy in metastatic renal cell carcinoma. TKI-associated cardiotoxicity was reported in approximately 10% of the patients. Detailed cardiovascular monitoring during TKI treatment may reveal early signs of myocardial damage. PATIENTS AND METHODS: In this observational, single-center study, all ...
Catena Emanuele - - 2008
Major perioperative cardiac complications, including cardiac death, nonfatal myocardial infarction and nonfatal cardiac arrest, can occur in patients undergoing noncardiac surgery. To reduce the risk of these complications, some authors have reported on the utility of intraoperative transesophageal echocardiography as a complementary monitoring tool in noncardiac surgery. However, although this ...
Dittrich Ralf - - 2008
BACKGROUND: In various cardiac diseases, thrombembolism constitutes a major risk, and in these patients clinically silent microembolic signals (MES) are detectable within the transcranial Doppler frequency spectrum (TCD) of the major brain arteries. MES are already an accepted surrogate parameter of the future risk of stroke in patients with carotid ...
Fontes Manuel L - - 2008
BACKGROUND: Among ambulatory patients, an increase in pulse pressure (PP) is a well-established determinant of vascular risk. The relationship of PP and acute perioperative vascular outcome among patients having coronary artery bypass graft (CABG) surgery is less well known. METHODS: We conducted a prospective observational study involving 5436 patients having ...
Sze Edward E Cardiology Division, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642-8653, - - 2008
Previous studies of long QT syndrome (LQTS) have focused primarily on the clinical course of affected patients up to 40 years of age to avoid the confounding influence of acquired heart disease on LQTS-related cardiac events in this genetic disorder. Patients were identified as having coronary disease if they had ...
Franklin Barry A - - 2008
PURPOSE OF REVIEW: To summarize changing paradigms and perceptions in the prevention and treatment of cardiovascular disease. RECENT FINDINGS: Recent studies have shown that arterial inflammation probably plays a key role in the development and progression of atherosclerosis, that acute myocardial infarctions often evolve from mild-to-moderate coronary artery stenoses, that ...
Fox Kim - - 2008
BACKGROUND: The BEAUTIFUL study assessed the morbidity and mortality benefits of the heart rate-lowering agent ivabradine. The placebo arm of the BEAUTIFUL trial was a large cohort of patients with stable coronary artery disease and left-ventricular dysfunction. We did a subanalysis of this placebo group to test the hypothesis that ...
Rubinshtein Ronen - - 2009
BACKGROUND: Contrast-enhanced multidetector cardiac computed tomographic angiography (CCTA) has high sensitivity and specificity for diagnosing anatomic coronary stenoses, but its role in predicting late clinical outcome events has not been well studied. METHODS: We examined predictive value of CCTA for late major adverse cardiovascular (CV) outcome events (MACE)(CV death, myocardial ...
Arroyo-Espliguero Ramón - - 2009
INTRODUCTION AND AIMS: Coronary occlusions resulting in acute events often occur at the site of non-severe stenoses. We sought to assess the prognostic value of non-obstructive coronary stenoses and C-reactive protein (CRP) levels in patients with chronic stable angina (CSA). METHODS: We studied 790 consecutive patients with CSA who underwent ...
Akcakoyun Mustafa - - 2008
BACKGROUND: Endothelial dysfunction plays a key role in atherosclerosis and predicts future cardiovascular events in individuals with or without coronary artery disease and improves with risk reduction therapy. We sought to determine the predictive value of endothelial dysfunction for long-term cardiovascular events and in-stent restenosis in patients undergoing percutaneous coronary ...
Schulz-Menger Jeanette - - 2008
Non-invasive myocardial tissue characterization of inflammatory heart disease is a challenging task. Cardiovascular magnetic resonance (CMR) has recently emerged as a powerful tool to fill this gap. In this article, the role of CMR is reviewed, particularly emphasizing the use of a comprehensive CMR approach to visualize several reversible and ...
Sousa Paulo - - 2008
OBJECTIVE: The aim of this study was to develop a risk adjustment model for major adverse cardiac and cerebrovascular events following percutaneous coronary intervention (PCI), using data from a national registry, and to highlight the use of the risk adjustment when we evaluate the quality of care in interventional cardiology. ...
Chase Paul - - 2008
Cardiopulmonary exercise testing (CPX) is an integral tool for assessing the clinical status and prognosis of patients with heart failure (HF). The present investigation examined differences in CPX variables and prognosis according to reason for test termination. One hundred eighty-three patients with HF (69% men, 31% women; mean age 53 ...
Biccard B M - - 2008
There is an increasing awareness that an elevated resting heart rate is associated with increased all-cause mortality in the general population and that this may be an independent coronary risk factor This review was undertaken to determine whether heart rate is predictive of increased mortality and major morbidity in noncardiac ...
Lévy L - - 2008
BACKGROUND: There is substantial evidence of excess cardiovascular morbidity and mortality in rheumatoid arthritis (RA) patients, but the related studies showed important variations in the estimation of the risk. We conducted a meta-analysis to evaluate more accurately the incidence of cardiovascular events, and the excess of cardiovascular risk in a ...
Reinhard Matthias M Dept. of Neurology, University of Freiburg, Neurocenter, Breisacherstr. 64, 79106, Freiburg, Germany. - - 2008
Dynamic cerebral autoregulation assessed from blood pressure transients can be considerably impaired in severe internal carotid artery (ICA) obstruction. It is unknown whether impaired autoregulation indicates an increased risk of subsequent ischemic events in this situation. 165 patients with ICA stenosis (> 70 %) or occlusion were prospectively followed until ...
Origasa Hideki - - 2008
BACKGROUND: A previous history of myocardial infarction (MI), stroke, and the presence of atrial fibrillation (AF) are known risk factors for the onset of arterial thromboembolic events such as MI and ischemic stroke. To clarify the rate of incidence of such events for these high-risk patients in Japan, a nation-wide ...
Umphrey Lisa G - - 2008
Cardiovascular (CV) complications are the leading cause of non-graft-related death in orthotopic liver transplant (OLT) patients. Pretransplant cardiac evaluation using dobutamine stress echocardiography (DSE) is commonly utilized for risk stratification of OLT candidates. To determine if clinical and echocardiographic variables identify patients with increased CV risk, we performed a retrospective ...
Lev Eli I - - 2008
Accurate risk stratification has an important role in the management of patients with acute coronary syndromes. Even in patients with ST-elevation acute myocardial infarction (STEMI), for whom early therapeutic options are well defined, risk stratification has an impact on early and late therapeutic decision making. We aimed to compare the ...
Bai Jingming - - 2008
AIMS: The aim of the current study was to clarify whether stress myocardial perfusion single-photon emission computed tomography (SPECT) stratifies perioperative cardiac risk in noncardiac surgery of diabetic patients without chest pain. METHODS: This study enrolled consecutive 284 patients with diabetes mellitus (DM) without chest pain who underwent noncardiac surgery ...
Georgoulias Panagiotis - - 2009
BACKGROUND: Heart-rate recovery (HRR) is considered to be an independent predictor of cardiac and all-cause mortality. We examined the long-term prognostic value of HRR in patients suffering from diabetes mellitus. METHODS: In this study, we included 258 consecutive patients. Patients whose HRR value or myocardial perfusion imaging could have been ...
Poldermans Don - - 2008
Perioperative myocardial infarctions are the predominant cause of morbidity and mortality in patients undergoing noncardiac surgery. The pathophysiology of perioperative myocardial infarction is complex. Prolonged myocardial ischemia due to the stress of surgery in the presence of a hemodynamically significant coronary lesion, leading to subendocardial ischemia, and acute coronary artery ...
Acampa Wanda - - 2008
OBJECTIVE: We assessed predictors and temporal characteristics of cardiac risk in patients undergoing stress single-photon emission computed tomography after coronary artery bypass grafting. METHODS: Stress cardiac tomography was performed in 362 patients 5 years after coronary artery bypass grafting. Cardiac death and myocardial infarction were considered as events. Cox proportional ...
Hogh Annette L - - 2008
High-sensitivity C-reactive protein is associated with increased risk of cardiovascular events. Consequently, the predictive value of this protein in patients with symptomatic peripheral arterial disease was examined. In all, 452 patients with symptomatic peripheral arterial disease had high-sensitivity C-reactive protein measured at baseline (mean follow-up = 2.1 +/- 1.4 years). ...
García-Almagro Francisco J - - 2008
INTRODUCTION: The Thrombolysis in Myocardial Infarction (TIMI) risk score (TRS) has proven to be a useful and simple tool for risk stratification of patients with chest pain in intermediate- and high-risk populations. There is little information on its applicability in daily clinical routine with unselected populations. AIMS: The aims of ...
Brown Elizabeth R - - 2008
PURPOSE: To develop a new calcium score for use with unenhanced cardiac computed tomography (CT) that can be used to define the percentage of coronary arteries affected by calcium and to correlate this score with risk factors and cardiovascular events. MATERIALS AND METHODS: Institutional review boards at all participating centers ...
Aboyans Victor - - 2008
OBJECTIVE: There is substantial evidence to consider both heart rate (HR) at rest and pulse pressure (PP) as significant markers of cardiovascular prognosis in the general population. Despite this, neither of these two parameters has been taken into consideration in the design of modern coronary artery bypass risk prediction scores, ...
Detrano Robert - - 2008
BACKGROUND: In white populations, computed tomographic measurements of coronary-artery calcium predict coronary heart disease independently of traditional coronary risk factors. However, it is not known whether coronary-artery calcium predicts coronary heart disease in other racial or ethnic groups. METHODS: We collected data on risk factors and performed scanning for coronary ...
Kunadian Babu - - 2008
To use funnel plots and cumulative funnel plots to compare in-hospital outcome data for operators undertaking percutaneous coronary interventions with predicted results derived from a validated risk score to allow for early detection of variation in performance. Analysis of prospectively collected data. Tertiary centre NHS hospital in the north east ...
Wang Angela Yee-Moon - - 2008
Mortality among patients with ESRD remains high because of an excessive cardiovascular risk related to a very high incidence of cardiac hypertrophy, cardiomyopathy, heart failure, and coronary artery disease. Identifying serum biomarkers that are useful in profiling cardiovascular risk and enabling stratification of early mortality and cardiovascular risk is an ...
Vernick William - - 2008
Perioperative cardiac complications pose the greatest risk to the estimated 100 million people undergoing non-cardiac surgery each year. Most of these complications are related to underlying pre-existing coronary artery disease (CAD). For over 40 years researchers have been studying perioperative cardiac risk and how best to estimate it. The goal ...
Mittnacht Alexander Jc - - 2008
Valvular heart disease can be an important finding in patients presenting for noncardiac surgery. Valvular heart disease and resulting comorbidity, such as heart failure or atrial fibrillation, significantly increase the risk for perioperative adverse events. Appropriate preoperative assessment, adequate perioperative monitoring, and early intervention, should hemodynamic disturbances occur, may help ...
Jaroszewski Dawn E - - 2008
OBJECTIVE: Recent literature has questioned the efficacy of routine detailed preoperative cardiac ischemia testing and preoperative cardiac intervention before noncardiac surgical procedures. METHODS: We performed a retrospective review of patients undergoing thoracotomy (n = 294) between January of 1999 and January of 2005. RESULTS: The median age was 62 years. ...
Naqvi Tasneem Z - - 2008
Atherosclerotic cardiovascular disease is the number one cause of death in Western countries and is a rapidly growing problem worldwide. The majority of patients who present with acute coronary syndrome often have a low cardiovascular risk score, which is insufficient to warrant treatment prior to an acute coronary event. Alternatively, ...
Lau K-K - - 2008
BACKGROUND: In patients with low-intermediate risk, the use of the Framingham Risk Score (FRS) may not allow accurate prediction of the occurrence of coronary events. OBJECTIVE: To determine whether non-invasive vascular sonographic assessments add value to the FRS for prediction of coronary events. METHODS: Brachial artery flow-mediated dilatation (FMD), carotid ...
Ribeiro Antonio Luiz Pinho - - 2008
BACKGROUND: The value of signal-averaged ECG (SAECG) in the risk stratification of Chagas disease (ChD), a potentially lethal illness prevalent in Latin America, remains controversial. The aim of this prospective longitudinal study was to determine the prognostic value of SAECG in ChD, using multivariate models with other established prognostic predictors, ...
Hutten Helmut - - 2009
Ventricular intramyocardial electrograms are recorded with electrodes directly from the heart either in intraventricular or epimyocardial position and may be acquired either from the spontaneously beating or from the paced heart. The morphology of these signals differs significantly from that of body surface ECG recordings. Although the morphology shows general ...
Shiina Yumi - - 2009
PURPOSE: We evaluated whether right ventricular (RV) diastolic dysfunction assessed by pulsed tissue Doppler imaging (TDI) predicts cardiac events in patients with chronic pulmonary thromboembolism (CPTE). MATERIALS AND METHODS: In 63 consecutive patients with CPTE, early diastolic myocardial velocity (Ea) at the tricuspid annulus by TDI and early diastolic tricuspid ...
Schoenenberger Andreas W - - 2008
BACKGROUND: Trials on implantable cardioverter-defibrillators (ICD) for patients after acute myocardial infarction (AMI) have highlighted the need for risk assessment of arrhythmic events (AE). The aim of this study was to evaluate risk predictors based on a novel approach of interpreting signal-averaged electrocardiogram (SAECG) and ejection fraction (EF). METHODS: SAECG, ...
Delaney E K - - 2008
OBJECTIVES: To evaluate the effects of nurse-led secondary prevention clinics for coronary heart disease (CHD) in primary care on total mortality and coronary event rates after 10 years. DESIGN: Follow-up of a randomised controlled trial by review of national datasets. SETTING: Stratified random sample of 19 general practices in northeast ...
Mastouri Ronald - - 2008
OBJECTIVE: We assessed the prognostic value of anatomic M-mode strain rate stress echocardiography (SRSE) in patients with known or suspected coronary artery disease. Previous studies showing that M-mode SRSE may be an accurate method for detection of coronary artery disease suggest that this technique may be useful for risk stratification. ...
Guazzi Marco - - 2009
BACKGROUND: Risk stratification for subsequent cardiovascular events following a myocardial infarction (MI) is an important area of research. Previous findings indicate flow-mediated dilatation (FMD) may be a valuable prognostic indicator. This study investigates the prognostic value of FMD in patients suffering an uncomplicated MI. METHODS: One hundred and seventy nine ...
Geluk, Christiane Anneliese
The aim of the thesis was to evaluate some of the unresolved issues on the pathway from risk association to risk stratification with regard to C-reactive protein, urinary albumin excretion and coronary calcium. This thesis shows that C-reactive protein is associated to angiographic evidence of coronary artery disease as well ...
Mocan Teodora - - 2008
The present report aims to generate a simple and efficient non-invasive prediction system of myocardial infarction as well as evaluating of the new generated score. METHODS: 208 patients (both men and women) aged 37-75 admitted at Centre Hospitalier Coulommiers, France, were included in the study. Patients were divided into two ...
Patel Salil J - - 2008
BACKGROUND: To estimate the prognostic value of submaximal negative dobutamine stress echocardiography (NDSE) on major cardiac events. METHODS AND RESULTS: Patients with NDSE were analyzed in 2 cohorts based on predicted maximal heart rate (PMHR) (< 85% or > or = 85% PMHR) and were assessed for major adverse cardiac ...
Vorlat Anne - - 2008
OBJECTIVES: To determine the value of the TIMI risk score in the individual risk stratification of patients with unstable angina/non-ST segment elevation myocardial infarction (UA/NSTEMI). BACKGROUND: TIMI risk score is a validated tool to identify groups of patients at high risk for major cardiac events. Its prognostic value in individual ...
Rosenlund Mats - - 2008
BACKGROUND: Long-term air pollution exposure is associated with increased mortality, but the association with incidence of fatal and nonfatal coronary heart disease is less certain. Moreover, it is unknown how chronic exposure to air pollution affects prognosis among survivors of a first coronary event. This study evaluated the association between ...
Behnes Michael - - 2008
BACKGROUND: Mid-regional pro-adrenomedullin (MR-proADM) and endothelin-1 have been shown to predict mortality of patients with acute myocardial infarction. However, the prognostic value of both biomarkers in predicting long-term clinical events after acute myocardial infarction remains unclear. METHODS: In a prospective study, 30 patients suffering from acute ST elevation myocardial infarction ...
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