Search Results
Results 551 - 600 of 1551
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Chalikias Georgios K - - 2007
BACKGROUND: The pro-inflammatory cytokine IL-18 has been suggested to play a role in atherogenesis and atheromatous plaque rupture leading to the acute coronary syndrome (ACS). Conversely, the anti-inflammatory cytokine IL-10 seems to have an atheroprotective role. Patients with unstable coronary artery disease show an imbalance between serum levels of pro- ...
Salem R - - 2006
BACKGROUND: Several risk factors have been shown to increase mortality in cardiac surgery. However, the importance of left ventricular end-diastolic pressure (LVEDP) as an independent risk factor before cardiac surgery is unclear. Method. This observational study investigated 3024 consecutive adult patients who underwent cardiac surgical procedures at the Montreal Heart ...
Bugiardini Raffaele - - 2006
BACKGROUND: The prognostic implication of chest pain associated with normal or near-normal findings on angiography is still unknown. We explored outcomes and methods of risk stratification in patients with nonobstructive coronary artery disease in the setting of non-ST-segment elevation acute coronary syndromes. METHODS: Data were pooled from 3 Thrombolysis in ...
Parissis John T - - 2007
Depression is a common comorbid condition in patients with coronary artery disease and a well-documented risk factor for recurrent cardiac events and mortality. The exact mechanisms underlying the interplay between depression and ischemic heart disease remain poorly understood and the same is true for the most effective depression treatment for ...
Dunkelgrun M - - 2006
Cardiovascular complications are important causes of morbidity and mortality following vascular surgery. Adequate preoperative risk assessment and perioperative management may modify postoperative mortality and morbidity and improve long-term prognosis. The objective of this review is to examine the present day knowledge regarding the preoperative evaluation and perioperative management of patients ...
Drury Nigel E - - 2006
The elderly represent a rapidly growing and substantially under-treated sector in industrialized countries, with coronary artery disease and degenerative aortic stenosis rampant. The proportion of elderly patients undergoing cardiac surgery is rising steadily and outcomes continue to improve with the refinement of operative techniques and perioperative care. Advanced risk stratification ...
Davila Jesse A - - 2006
PURPOSE: To retrospectively determine whether calcium scores of the abdominal aorta obtained during computed tomographic (CT) colonography relate to Framingham risk factors and clinical cardiac events. MATERIALS AND METHODS: The institutional review board approved the current HIPAA-compliant retrospective study and waived informed consent. Between 1995 and 1998, 480 patients underwent ...
Wake Ryotaro - - 2006
BACKGROUND: Non-invasive diagnosis and risk stratification of coronary artery disease are important for the selection and optimization of therapeutic interventions in diabetic patients, which may improve survival. The aim of this study was to determine the incremental value of contrast-enhanced dobutamine stress echocardiography (CE-DSE) for risk stratification. METHODS AND RESULTS: ...
Haim Moti - - 2007
We have prospectively evaluated the risk of incident coronary events in association with serum total homocysteine in patients with preexisting chronic coronary heart disease. A nested case-control design was used. Total homocysteine concentration was measured in baseline fasting serum samples from patients with chronic coronary heart disease enrolled in the ...
De Denus Simon - - 2006
BACKGROUND: The implication of various cytokines in a subclinical inflammatory process has been documented in heart failure (HF). The role of temporal changes of more conventional markers of inflammation, such as the white blood cell (WBC) count, on clinical outcomes remains largely unknown. METHODS AND RESULTS: We performed a retrospective ...
Bremmer Marijke A - - 2006
OBJECTIVE: Depressive disorders have been shown to be associated with cardiac diseases and death, but the underlying disease mechanism is unclear. The authors hypothesized that the cardiac morbidity and mortality after depression in late life is mediated by subclinical atherosclerosis and is thus confined to ischemic heart diseases. METHOD: Using ...
Alonso-Gómez Angel M AM Servicio de Cardiología, Hospital Txagorritxu, Vitoria-Gasteiz, Álava, - - 2006
In patients with an inferior myocardial infarction (IMI), ST-segment depression in left precordial leads during exercise electrocardiography (ExECG) has been associated with left anterior descending coronary artery (LADCA) disease. The aim of this study was to assess the value of stress echocardiography in identifying LADCA disease in patients with IMI ...
Gal J - - 2006
Cardiac complications are the major cause of perioperative morbidity and mortality of patients undergoing non-cardiac surgery. This is related to the frequent presence of underlying coronary artery disease. In the last few decades, attention has focused on preoperative cardiac risk assessment that may help to identify patients at increased cardiac ...
Ohtani Tomohito - - 2006
OBJECTIVES: We sought to test whether the risk of acute coronary syndrome (ACS) can be estimated by angioscopy. BACKGROUND: Disruption of vulnerable plaque and subsequent thrombosis is regarded as a major mechanism of ACS. Although yellow plaques are supposedly vulnerable, the association between angioscopically determined extent of coronary atherosclerosis and ...
Healy Aileen M - - 2006
BACKGROUND: Platelets participate in events that immediately precede acute myocardial infarction. Because platelets lack nuclear DNA but retain megakaryocyte-derived mRNAs, the platelet transcriptome provides a novel window on gene expression preceding acute coronary events. METHODS AND RESULTS: We profiled platelet mRNA from patients with acute ST-segment-elevation myocardial infarction (STEMI, n=16) ...
Engström G - - 2006
Hypertension has been associated with increased case-fatality rates among individuals who subsequently suffer from acute coronary events. It is unknown whether inflammation modifies this relationship. This population-based study explored the effects of inflammation and hypertension on incidence of coronary event, and on the fatality of the future events. Blood pressure ...
Huang Po-Hsun - - 2007
BACKGROUND: Heparin cofactor II (HCII) could inactivate thrombin after binding to dermatan sulfate at injured arterial walls, and has been shown to be a novel and independent antiatherosclerotic factor. However, the relation between plasma HCII activity and peripheral vascular endothelial function remains unclear. METHODS: A total of 199 patients (mean ...
Polk Donna M - - 2006
Hospitalization and rehospitalization for acute coronary syndromes significantly contribute to the rising annual cost of healthcare. Despite growing evidence of the effectiveness of early and aggressive treatment of cardiovascular risk factors at the time of an acute event, eligible individuals are still not receiving adequate therapy. Inclusion of appropriate coronary ...
van der Harst Pim - - 2006
High levels of C-reactive protein and soluble intercellular adhesion molecule-1 are associated with increased risk for cardiovascular events. No long-term data are available on predictive value of preoperative levels of C-reactive protein and soluble intercellular adhesion molecule-1 on outcome after coronary artery bypass grafting. We measured baseline levels of C-reactive ...
Arima Hisatomi - - 2006
BACKGROUND AND PURPOSE: The relationship between baseline and recurrent vascular events may be important in the targeting of secondary prevention strategies. We examined the relationship between initial event and various types of further vascular outcomes and associated effects of blood pressure (BP)-lowering. METHODS: Subsidiary analyses of the Perindopril Protection Against ...
Church Timothy S - - 2007
BACKGROUND: Whether the absence of coronary artery calcium, or conversely the presence of high volumes of coronary artery calcium, may alter assessment of coronary heart disease risk based on traditional risk factors is uncertain. We sought to identify a potential threshold of coronary artery calcium for clinical use and examine ...
Ivanov Joan - - 2006
OBJECTIVE: To develop and validate an objective and reliable measure of acuity that will identify high-risk patients and predict length of stay following all cardiac surgery procedures. METHODS: Logistical regression analysis of 12,683 patients undergoing cardiac surgery between 1996 and 2000 was used to identify the independent predictors of postoperative ...
Zacharoulis Achilles - - 2006
BACKGROUND: Recent studies have shown that the odds ratio for high-sensitivity C-reactive protein (CRP) in predicting a coronary events in healthy subjects is 1.4, a value substantially less than previously reported. It is unclear whether this extends to acute coronary syndrome patients or if CRP would predict long-term events in ...
Noordzij Peter G - - 2006
Electrocardiography is commonly performed as part of preoperative cardiovascular risk assessment in patients undergoing noncardiac surgery. However, the prognostic value of such electrocardiography is still not clear. This study retrospectively studied 23,036 patients who underwent 28,457 surgical procedures at Erasmus Medical Center from 1991 to 2000. Patients were screened before ...
Wong Daniel R - - 2006
OBJECTIVE: Increasing attention has been afforded to the ubiquity of medical error and associated adverse events in medicine. There remains little data on the frequency and nature of precursor events in cardiac surgery, and we sought to characterize this. METHODS: Detailed, anonymous information regarding intraoperative precursor events (which may result ...
Anand Dhakshinamurthy Vijay - - 2006
AIMS: To determine the prevalence and clinical predictors of subclinical atherosclerosis and myocardial ischaemia in uncomplicated type 2 diabetes and assess their relationship to short-term outcome. METHODS AND RESULTS: Established risk factors and coronary artery calcium (CAC) scores were prospectively measured in 510 asymptomatic type 2 diabetic subjects (mean age ...
Denollet Johan - - 2006
Psychological stress and type D personality have been associated with adverse cardiac prognosis, but little is known about their relative effect on the pathogenesis of coronary heart disease (CHD). "Type D" refers to the tendency to experience negative emotions and to inhibit the expression of these emotions in social interactions. ...
Budoff Matthew J - - 2006
Over the last decade, there has been increased recognition that atherosclerosis imaging adds greatly to the ability to identify patients at high risk for cardiac events. Technologies such as electron beam computed tomography and carotid intimal media thickness have contributed significantly to our understanding of the prevalence of preclinical atherosclerosis ...
Brown K L - - 2006
To assess whether the route by which neonatal congenital heart disease (CHD) is first recognised influences outcome after surgery. Surgical neonates admitted to a tertiary cardiac unit between March 1999 and February 2002 were retrospectively reviewed with analysis of risk factors for outcome. Three routes to initial recognition of CHD ...
Lucas F L - - 2006
Rates of invasive testing and treatment for coronary artery disease have increased over time. Less is known about trends in the utilization of noninvasive cardiac testing for coronary artery disease. The objective of this study was 2-fold: to explore temporal trends in the utilization of noninvasive and invasive cardiac services ...
Franks Jr., Billy Joe
Many characteristics for predicting death due to coronary heart disease are measured on a continuous scale. These characteristics, however, are often categorized for clinical use and to aid in treatment decisions. We would like to derive a systematic approach to determine the best categorizations of systolic blood pressure and cholesterol ...
Lekatsas Ioannis - - 2006
BACKGROUND: The aim of this study was to examine whether the presence of microalbuminuria (20-200 microg/min) can predict in-hospital morbidity and mortality in non-diabetic patients with acute myocardial infarction. METHODS: Two hundred twenty-three (172 men and 51 women) non-diabetic patients with acute myocardial infarction were studied prospectively. The main outcome ...
Daly Caroline A - - 2006
To investigate the prognosis associated with stable angina in a contemporary population as seen in clinical practice, to identify the key prognostic features, and from this to construct a simple score to assist risk prediction. Prospective observational cohort study. Pan-European survey in 156 outpatient cardiology clinics. 3031 patients were included ...
Iso Hiroyasu - - 2006
BACKGROUND: Once- or twice-weekly consumption of fish (or a small amount of fish intake) reduces the risk of coronary heart disease and sudden cardiac death in Western countries. It is uncertain whether a high frequency or large amount of fish intake, as is the case in Japan, further reduces the ...
Nagamachi Shigeki - - 2006
BACKGROUND: 123I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy is a useful tool for diagnosing cardiac autonomic neuropathy (CAN) in non-insulin-dependent diabetes mellitus (NIDDM). However, the long-term prognostic value for cardiac events or mortality in NIDDM has not been clarified. METHODS AND RESULTS: We investigated the long-term prognostic value of cardiac MIBG imaging for ...
Karthikeyan G - - 2006
Many patients undergo non-invasive testing for the detection of coronary artery disease before non-cardiac surgery. This is despite the low predictive value of positive tests in this population and the lack of any evidence of benefit of coronary revascularisation before non-cardiac surgical procedures. Further, this strategy often triggers a clinical ...
Hassapoyannes Constantine A - - 2006
BACKGROUND: Patients with coronary artery disease are at increased risk from noncardiac surgery. We examined a population of cardiac patients undergoing noncardiac surgery to determine whether coronary angiography was successfully utilized to identify and treat ischemic heart disease. Our hypothesis was that cardiac complications would not differ between the group ...
Zamarripa Daniel - - 2006
EBCT measured coronary calcium is fast becoming a standard screening tool in asymptomatic patients with and without risk factors who apply for life insurance. Since atherosclerotic plaques become calcified as part of their natural history, the calcium score is an excellent measure of total atherosclerotic burden. Over the past 5 ...
Gopal Ambarish - - 2006
While there is no doubt that high-risk patients (those with more than a 20% 10-year risk of a future cardiovascular event) need more aggressive preventive therapy, a majority of cardiovascular events occur in individuals at intermediate risk (10%-20% 10-year risk). Data suggest that it will be most cost-effective to concentrate ...
Dondero Federica - - 2006
Donor risk is the main obstacle in the development of living-donor liver transplantation in Western countries. The knowledge of a wide and uneven range of donor morbidity has come mainly from various retrospective analyses of complications in the literature. Donor outcomes have not been prospectively analyzed. From 1995, the intra- ...
Samad Khalid - - 2006
Patients with recent myocardial infarction (MI), congestive heart failure, severe angina, or uncorrected multivessel coronary artery disease are at increased risk of cardiac complications after urgent major non-cardiac surgery. Although invasive haemodynamic monitoring and preoperative optimization of cardiac status may lead to some reduction in the rate of perioperative cardiac ...
Benninghoven D - - 2006
BACKGROUND: There is a lack of clarity concerning the effect of anxiety on the course of cardiac events following myocardial infarction. Some studies have identified anxiety as a risk factor for further cardiac events. However, it is also considered to be a protective factor, as a higher level of anxiety ...
Campbell Duncan J - - 2006
Angiotensin-converting enzyme inhibitors (ACEI) have a well-established role in the prevention of cardiovascular events in hypertension, left ventricular dysfunction, and heart failure. More recently, ACEI have been shown to prevent cardiovascular events in individuals with increased cardiovascular risk, where hypertension, left ventricular dysfunction, or heart failure was not the primary ...
Virani Salim S - - 2006
Although most patients with left main coronary artery stenosis undergo urgent coronary artery bypass grafting, limited information is available regarding the risk factors that might lead to cardiac events between angiographic diagnosis and surgery. We retrospectively reviewed 1,731 cases of coronary artery bypass grafting at our institution, 97 of which ...
Escabí-Mendoza José - - 2005
Patients hospitalized with unstable angina (UA) or with a non-ST segment elevation myocardial infarct (NSTEMI) are at increased risk of suffering refractory angina, recurrent myocardial infarct (MI), and death. These patients need to be evaluated more aggressively. According to the last published guidelines (2002) of UA/NSTEMI by the ACC/AHA Task ...
Roy Archana - - 2005
Postoperative adverse myocardial ischemic events, such as infarction, unstable angina, and cardiac death, are common in patients with coronary artery disease (CAD). These events can be prevented in many patients with strategies such as the perioperative use of beta-blockers. In this article, the authors present four cases and discuss perioperative ...
Radosavljevic-Radovanovic Mina - - 2005
To investigate whether biphasic response during dipyridamole echocardiography test (DET), which represents viable but potentially ischemic myocardium in the infarcted region, affects prognosis of patients after uncomplicated acute myocardial infarction, we performed high-dose DET in 80 consecutive patients younger than 65 years with first acute myocardial infarction and preserved left ...
Dick P - - 2005
BACKGROUND: A functional GT dinucleotide length polymorphism in the haem oxygenase-1 (HO-1) gene promoter is thought to be involved in the pathogenesis of cardiovascular disease. Short (< 25) (GT)n repeats are suggested to facilitate enhanced HO-1 up-regulation in response to injury and confer potent anti-inflammatory and antioxidative effects. MATERIALS AND ...
Kikura Mutsuhito - - 2005
HYPOTHESIS: Preexisting morbidities are risk factors for perioperative arterial or venous thromboembolic events and subsequent death within 30 postoperative days. DESIGN: Prospective cohort study. SETTING: University-affiliated general hospital. PATIENTS: A total of 21,903 surgery patients treated from January 1, 1991, through December 31, 2002. MAIN OUTCOME MEASURES: Independent risk factors ...
Rao Sunita - - 2005
AIM: To study prognostic value of 99mTc-Sestamibi stress Myocardial Perfusion Single Photon Emission Computed Tomography (SPECT) in suspected or diagnosed ischemic heart disease, in an urban Indian population. METHODS: Eight hundred and eighty one patients with clinically suspected or diagnosed ischemic heart disease who underwent 99mTc-MIBI stress-rest Myocardial Perfusion SPECT ...
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