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Results 101 - 150 of 1811
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Berredjeb Ben Slama Dhouha - - 2012
BACKGROUND: Myocardial infarction is a multifactorial disease. It is provoked by occlusions in the coronary arteries resulting from exposure to multiple risk factors. OBJECTIVE: To study the risk of myocardial infarction associated with the gene polymorphisms of factor V Leiden and factor II (G20210A). MATERIALS AND METHODS: Cases consisted of ...
Stefan Liliana - - 2012
AIMS: Cardiac resynchronization therapy (CRT) can result in profound reverse remodelling. The goal of this study was to identify factors predictive of such beneficial response.METHODS AND RESULTS: Super-response to CRT was defined as normalization or near normalization of left ventricular systolic function without recognized reversible causes of heart failure. In ...
Fertin Marie - - 2012
Left ventricular (LV) remodeling after myocardial infarction (MI) indicates a high risk of heart failure and death, but LV remodeling remains difficult to predict. Biomarkers may help to refine risk stratification for a more personalized medical approach. They may also shed light on the pathophysiologic processes involved. We performed a ...
de Waure Chiara - - 2012
Advances in electronics and communications have changed modern medicine: telemedicine allows patient assessment and monitoring to facilitate healthcare at a distance. The aim of this study was to perform a systematic review and meta-analysis to assess how telemedicine systems, including early telemetry of electrocardiograms, can improve health outcomes in patients ...
Bertrand Olivier F - - 2012
Despite lower risks of access site-related complications with transradial approach (TRA), its clinical benefit for percutaneous coronary intervention (PCI) is uncertain. We conducted a systematic review and meta-analysis of clinical studies comparing TRA and transfemoral approach (TFA) for PCI. Randomized trials and observational studies (1993-2011) comparing TRA with TFA for ...
Kypson Alan P - - 2012
In the past, hemophiliacs rarely underwent cardiac surgery because of limited lifespan. As blood transfusions have become safer, hemophiliacs are living longer and becoming more susceptible to diseases that afflict the elderly, such as coronary atherosclerosis. We describe the hematologic management of a patient with hemophilia A who underwent coronary ...
Trkulja Vladimir - - 2012
To evaluate the prognostic value of serum uric acid (SUA) in acute myocardial infarction (AMI) patients. Systematic review and random-effects meta-analysis of prognostic studies assessing AMI outcomes (death, major adverse cardiac events, MACE) in relation to on-admission SUA. Nine studies (7655 patients) were identified, 6 in the ST-segment elevation AMI ...
Dhar Rajat - - 2012
Aneurysmal subarachnoid hemorrhage (SAH) induces a potent inflammatory cascade that contributes to endothelial dysfunction, imbalance of vasoactive substances (excess endothelin, depletion of nitric oxide), and arterial vasospasm. This process results in delayed cerebral ischemia, a major cause of neurologic disability in those surviving the initial hemorrhage. The only therapy shown ...
Wong Dennis T L - - 2012
To investigate whether grid-tag myocardial strain evaluation can characterise 'border-zone' peri-infarct region and identify patients at risk of ventricular arrhythmia as the peri-infarct myocardial zone may represent an important contributor to ventricular arrhythmia following ST-segment elevation myocardial infarction (STEMI). Forty-five patients with STEMI underwent cardiac magnetic resonance (CMR) imaging on ...
Bersin Robert M - - 2012
BACKGROUND: The clinical risk predictors for adverse events in carotid stenting using distal embolic protection devices are well established and include patient age and symptomatic status. The risk predictors for adverse events with proximal occlusion devices are not as well established. The present study is a meta-analysis of available data ...
Reddy Sushma - - 2012
MicroRNAs (miRs) are small, noncoding RNAs that are emerging as crucial regulators of cardiac remodeling in left ventricular hypertrophy (LVH) and failure (LVF). However, there are no data on their role in right ventricular hypertrophy (RVH) and failure (RVF). This is a critical question given that the RV is uniquely ...
Lamy André - - 2012
The relative benefits and risks of performing coronary-artery bypass grafting (CABG) with a beating-heart technique (off-pump CABG), as compared with cardiopulmonary bypass (on-pump CABG), are not clearly established. At 79 centers in 19 countries, we randomly assigned 4752 patients in whom CABG was planned to undergo the procedure off-pump or ...
Ozeke Ozcan - - 2012
BACKGROUND: Both obstructive sleep apnea (OSA) and coronary slow-flow phenomenon (CSFP) are known to share similar etiopathogenic mechanisms, such as chronic sympathetic activation, upregulation of inflammatory pathways, oxidative stress and, finally, endothelial dysfunction. OBJECTIVE: We evaluated whether there is an association between OSA and coronary flow rates. METHOD: We retrospectively ...
Kozieradzka A - - 2012
Purpose: Methylenetetrahydrofolate reductase (MTHFR) is an enzyme involved in endothelial nitric oxide synthase (eNOS) coupling and homocysteine metabolism. The rs1801133 polymorphism of the MTHFR gene affects risk of coronary artery disease. We assessed its influence on 5-year survival of patients with ST-elevation acute myocardial infarction (STEMI).Material/Methods: The study group comprised ...
Chatterjee Neal A - - 2012
For patients with refractory atrial fibrillation (AF) undergoing atrioventricular nodal ablation (AVNA), initial single-chamber right ventricular (RV)-only pacing is standard. Given the deleterious effects of chronic RV-only pacing, the impact of an initial biventricular (BiV) pacing strategy post-ablation is of interest. We conducted a meta-analysis to determine the effect of ...
Colais Paola - - 2012
BACKGROUND: Although numerous studies have provided evidence of an association between ambient air pollution and acute cardiac morbidity, little is known regarding susceptibility factors. METHODS: We conducted a time-stratified case-crossover study in 9 Italian cities between 2001 and 2005 to estimate the short-term association between airborne particles with aerodynamic diameter ...
Nielsen Lisa Seto - - 2012
seto nielsen l., angus j.e., lapum j., dale c., kramer-kile m., abramson b., marzolini s., oh p., price j. & clark a. (2012) "I can't just follow any particular textbook": immigrants in cardiac rehabilitation. Journal of Advanced Nursing00(0), 000-000. doi: 10.1111/j.1365-2648.2012.05975.x ABSTRACT: Aim.  The study purpose was to examine how and ...
Zhang Yujiao - - 2012
Cardiac Autonomic Denervation and AF. Introduction : Adjunctive complex fractionated atrial electrograms (CFAE) ablation or ganglionated plexi (GP) ablation have been proposed as new strategies to increase the elimination of AF, but the difference between CFAE/GP ablation and pulmonary vein isolation (PVI), as well as the combined effect of CFAE/GP ...
Mavrogeni S - - 2012
Objectives: To investigate the pathophysiology of Q waves in II, III, avF in systemic lupus erythematosus (SLE) by cardiovascular magnetic resonance (CMR). Methods: Inflammation evaluation by CMR using T2, early (EGE) and late gadolinium enhanced images (LGE) was performed in 20 SLE patients with mild cardiac symptoms and Q in ...
Upchurch Charles T - - 2012
Sensitive tools are available to diagnose occult ischemic and atherosclerotic coronary disease, yet screening for coronary artery disease (CAD) has not been shown to reduce cardiac events in patients with type 2 diabetes mellitus (T2DM). Professional guidelines are inconsistent regarding CAD screening recommendations, but it is suggested that those at ...
Intzilakis T - - 2012
Aim  As both impaired fasting glucose and silent myocardial ischaemia are risk factors for cardiovascular disease and death, we hypothesized that these risk factors in combination would identify those subjects at the highest risk of adverse events. Methods  Healthy individuals without diabetes (n = 596, 55-75 years) were examined for silent myocardial infarction ...
Xie Fangyi - - 2012
BACKGROUND: The chitinase-like 1 protein, YKL-40, is involved in inflammation and tissue remodeling. Patients with coronary heart disease (CHD) and acute myocardial infarction have elevated levels of serum YKL-40. The goal of the present study was to investigate whether the chitinase-like 1 gene-329G/A variant (rs10399931) confers susceptibility to CHD, and ...
Desch S - - 2012
OBJECTIVE: We performed a meta-analysis of randomized controlled trials to compare coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) for the treatment of de novo unprotected left main disease. BACKGROUND: Although CABG is accepted to be standard of care for revascularization of unprotected left main stenosis, PCI is ...
Munk Kim - - 2012
BACKGROUND: Left ventricular systolic function is a key determinant of outcome after ST-segment elevation myocardial infarction (STEMI). The aim of this study was to study speckle-tracking global longitudinal strain (GLS) for early risk evaluation in STEMI and compare it with left ventricular ejection fraction (LVEF), wall motion score index (WMSI), ...
Scolletta Sabino - - 2012
ABSTRACT: INTRODUCTION: Therapeutic hypothermia is largely used to protect the brain following return of spontaneous circulation (ROSC) after cardiac arrest (CA), but it is unclear whether we should start therapeutic hypothermia earlier, i.e., before ROSC. METHODS: We performed a systematic search of PubMed, EMBASE, CINAHL, the Cochrane Library and Ovid/Medline ...
Sutaria Shailen S Department of Epidemiology and Public Health, University College London, London, UK. - - 2012
Translational phases of study are important in evaluating whether a prognostic biomarker is likely to have impact on clinical practice but systematic evaluations of such evidence are lacking. To systematically evaluate the clinical usefulness of the published literature on the association of natriuretic peptides (NP) and prognosis in stable coronary ...
Gupta Anurag - - 2012
Prior studies have indicated that the magnitude of risk association of microvolt T-wave alternans (MTWA) testing appears to vary with the population studied. We performed a meta-analysis to determine the ability of MTWA to modify risk assessment of ventricular tachyarrhythmic events (VTEs) and sudden cardiac death (SCD) across a series ...
Hinchcliff Monique - - 2012
To determine the frequency, associated clinical factors, and prognostic significance of left ventricular (LV) diastolic dysfunction in systemic sclerosis (SSc). We studied 153 consecutive patients with SSc and divided the study sample into those with and without LV diastolic dysfunction using established age-based normal cut-offs for lateral tissue Doppler early ...
Friedland Sayuri N - - 2012
Cilostazol is a generic drug with antiplatelet and antiproliferative effects. It is unclear whether adding cilostazol to standard dual antiplatelet therapy (aspirin and clopidogrel) after percutaneous coronary intervention reduces restenosis and improves the outcomes. We, therefore, conducted a systematic review and meta-analysis. We systematically searched the Cochrane Library, EMBASE, and ...
Novack Victor - - 2012
BACKGROUND: The universal definition of myocardial infarction specifies creatine kinase-MB fraction (CKMB) or troponin values more than 3 times the 99th percentile of the upper reference limit as diagnostic after percutaneous coronary intervention, with a preference for the use of troponin. METHODS: Outcomes of 4930 patients with elective coronary stent ...
Kajimoto Kan - - 2012
Coronary artery bypass surgery (CABG) is the standard treatment for left main coronary artery (LMCA) disease. However, percutaneous coronary intervention using drug-eluting stents (DES-PCI) is now widely used and is associated with improved outcomes following coronary revascularization. The goal of this study was to assess early outcomes associated with CABG ...
Konishi Masaaki - - 2012
BACKGROUND: Left ventricular diastolic dysfunction (LVDD) plays an important role in heart failure with normal left ventricular ejection fraction (LVEF). Obesity is one of the major comorbid conditions of LVDD. Pericardial fat (PF) is an ectopic fat depot with possible paracrine or mechanical effects on the coronary circulation and myocardial ...
Kim Eric S - - 2012
This study examined whether purpose in life was associated with myocardial infarction among a sample of older adults with coronary heart disease after adjusting for relevant sociodemographic, behavioral, biological, and psychological factors. Prospective data from the Health and Retirement Study-a nationally representative panel study of American adults over the age ...
Cheng Yu-Ching YC Department of Medicine, University of Maryland School of Medicine, 660 W Redwood St, Howard Hall, Room 492, Baltimore, MD 21201, - - 2012
Ischemic stroke (IS) shares many common risk factors with coronary artery disease (CAD). We hypothesized that genetic variants associated with myocardial infarction (MI) or CAD may be similarly involved in the etiology of IS. To test this hypothesis, we evaluated whether single-nucleotide polymorphisms (SNPs) at 11 different loci recently associated ...
Osadchii Oleg E - - 2012
AIM: Endocardial pacing instituted to treat symptomatic bradycardia may nevertheless promote tachyarrhythmia in some pacemaker-implanted patients. We sought to determine the contributing electrophysiological mechanisms. METHODS: Left ventricular (LV) monophasic action potential duration (APD(90) ) and effective refractory periods (ERP) were determined in perfused guinea-pig hearts along with volume-conducted ECG recordings ...
Goliasch Georg - - 2012
OBJECTIVE: Besides its effects on glucose and lipid metabolism, the Wnt pathway has been increasingly implicated in the regulation of proliferation, migration and survival of vascular cells. In addition, defective Wnt signaling has been identified in a family with autosomal dominant early coronary artery disease. The aim of this study ...
Johnman Cathy - - 2012
OBJECTIVE: To assess short-term and medium-term outcomes following radial and femoral artery access for primary or rescue percutaneous coronary intervention (PCI). DESIGN: Retrospective cohort study. SETTING: Scotland-wide. PATIENTS: All 4534 patients undergoing primary or rescue PCI in Scotland between April 2000 and March 2009 using the Scottish Coronary Revascularisation Register. ...
Goldberg David J - - 2012
The objective of this study was describe the impact of sildenafil on echocardiographic measures of myocardial performance in children and young adults with a functional single-ventricle physiology late after Fontan surgery. A double-blind, placebo-controlled, crossover trial was conducted in children and young adults after the Fontan operation at a single ...
Nie Shao-Ping - - 2012
BACKGROUND: Coronary slow flow phenomenon (CSFP) is an important, angiographic clinical entity, but its etiology remains unclear. The purpose of this study was to explore the potential role of local coronary anatomic properties in the genesis of CSFP. METHODS: One hundred and thirty-one consecutive patients with CSFP and 131 patients ...
Crotti Lia - - 2012
Although QT prolongation following myocardial infarction (MI) is generally moderate, cases with marked QT prolongation leading to life-threatening torsades de pointes (TdP) have been described. To investigate the genetic substrate of this phenomenon. We studied 13 patients who developed TdP in the subacute phase of MI (2-11 days) and a ...
van Ballegooijen A J - - 2012
Background and Aims: To investigate associations between baseline serum 25-hydroxyvitamin D [25(OH)D] levels and myocardial structure and function after 8 years of follow-up in older Dutch subjects. Methods: We included 256 subjects of the Hoorn Study, a population-based cohort. They underwent a standardized 2-dimensional echocardiogram at baseline between 2000 and ...
Fernandes Fernanda P - - 2012
BACKGROUND: Left ventricular (LV) dysfunction is common in adults late after repair of tetralogy of Fallot (TOF). The early detection of myocardial dysfunction may be important, but LV myocardial strain and dyssynchrony are not well studied in children with TOF. The objective of this study was to investigate LV strain ...
Creemers Esther E - - 2012
In the past few years, the crucial role of different micro-RNAs (miRNAs) in the cardiovascular system has been widely recognized. Recently, it was discovered that extracellular miRNAs circulate in the bloodstream and that such circulating miRNAs are remarkably stable. This has raised the possibility that miRNAs may be probed in ...
Wende R - - 2012
Aims: The potential influence of lunar phases on the occurrence of myocardial infarction is still controversial. The purpose of the present study was to investigate the association of the lunar cycle on the occurrence of fatal and non-fatal myocardial infarction based on a myocardial infarction registry.Methods and results: We studied ...
Alreja Gaurav - - 2012
The purpose of this study was to assess the effect of remote ischemic precondition (RIPC) on the incidence of myocardial and renal injury in patients undergoing cardiovascular interventions as measured by biomarkers. Clinical data were pooled to evaluate the usefulness of RIPC to benefit clinical outcomes. Debate exists regarding the ...
Schelleman Hedi - - 2012
The authors sought to determine whether use of methylphenidate in adults is associated with elevated rates of serious cardiovascular events compared with rates in nonusers. This was a cohort study of new users of methylphenidate based on administrative data from a five-state Medicaid database and a 14-state commercial insurance database. ...
Grandi Norma Christine - - 2012
High serum calcium and phosphate levels have been linked to cardiovascular diseases and all-cause mortality but evidence from longitudinal studies is scarce, especially among patients with pre-existing coronary heart disease. The association between baseline calcium and phosphate and prognosis was examined in a cohort study of patients with stable coronary ...
Shannon Joanne - - 2012
The primary objective of invasive treatment strategies for multivessel coronary artery disease is complete anatomical revascularization-traditionally considered the strongest predictor of improved clinical outcome in this setting. This concept, however, is being challenged by evidence suggesting that addressing ischemia is the key to reducing mortality, myocardial infarction, and life-limiting angina. ...
Rubin Jonathan J Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, - - 2012
The purpose of this study was to examine the association between hyperglycemia and subclinical myocardial injury in persons without clinically evident coronary heart disease (CHD). Hyperglycemia is associated with an increased risk of cardiac events, but limited information is available on its relationship to subclinical myocardial damage. Elevated cardiac troponin ...
Ades Philip A PA Division of Cardiology, University of Vermont College of Medicine, University Health Center Campus, 1 S. Prospect St, Burlington, VT 05401, USA. - - 2012
Coronary atherosclerosis is a complex entity with behavioral, genetic and environmental antecedents. Most risk factors for coronary heart disease have a behavioral component. These include tobacco use, hyperlipidemia, hypertension, obesity, insulin resistance, diabetes and physical inactivity. The role of monetary incentives to encourage healthful behaviors related to the prevention and ...
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