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Holley Christopher T CT University of Minnesota Department of Surgery, Minneapolis, MN 55455, - - 2014
Heart failure remains a significant cause of morbidity and mortality, affecting over five million patients in the United States. Continuous-flow left ventricular assist devices (LVAD) have become the standard of care for patients with end stage heart failure. This review highlights the current state of LVAD as a bridge to ...
Evenson Kelly R KR Department of Epidemiology, Gillings School of Global Public Health (Drs Evenson and Rosamond and Ms Butler) and Center for Health Promotion and Disease Prevention (Dr Evenson), University of North Carolina at Chapel - - 2014
Physical activity (PA) is recommended for primary and secondary prevention of cardiovascular disease (CVD). This study described the prevalence of self-reported and accelerometer-measured PA and sedentary behavior, using a nationally representative sample from the United States, a subset of whom had CVD, including angina, coronary heart disease (CHD), congestive heart ...
Kim Luke K LK Division of Cardiology, Department of Medicine, Weill Cornell Medical College, New York Presbyterian Hospital, New York, New York. Electronic address: - - 2014
Although the benefit of percutaneous coronary interventions (PCIs) for patients presenting with acute coronary syndromes (ACS) has been established in numerous studies, the role of PCI in stable coronary artery disease (CAD) remains controversial. With the publication of the Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluations trial and the ...
Seward James B JB aDepartment of Adult and Pediatric Cardiology bDivision of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, - - 2014
This article provides a state-of-the-art perspective of left atrial anatomy and physiology. Left atrial structure and function can be used to reflect and quantify the physiologic state of complex disease processes. No single left atrial anatomic, functional, or clinical feature will adequately define a complex system. The state of combined ...
Brilakis Emmanouil S ES Dallas VA Medical Center (111A), 4500 South Lancaster Road, Dallas, TX 75216 USA. - - 2014
Percutaneous coronary intervention (PCI) of chronic total occlusions (CTOs) is a rapidly developing field. In the present review, we summarize the most important CTO PCI related literature published in 2013.
Hendgen-Cotta Ulrike B UB University Hospital Düsseldorf, Medical Faculty, Division of Cardiology, Pulmonology and Vascular Medicine, Moorenstrasse 5, D-40225 Düsseldorf, Germany. Electronic address: - - 2014
The physiological role of myoglobin (Mb) within the heart depends on its oxygenation state. The myocardium exhibits a broad oxygen partial pressure (pO2) spectrum with a transmural gradient from the epicardial to the subendocardial layers, ranging from arterial values to an average of 19.3mmHg down to 0mmHg. The function of ...
Papayan Garry G Center of Laser Medicine, Department of Pathophysiology, First I.P. Pavlov Federal Medical University of St. Petersburg, Lev Tolstoy Str. 6/8, 197022, St. Petersburg, Russian Federation; Institute of Experimental Medicine, Federal Almazov Medical Research Centre, Akkuratova Str. 2, 197341, St. Petersburg, Russian - - 2014
Reduction of myocardial ischemia-reperfusion injury in the patients undergoing cardiac surgery under cardiopulmonary bypass represents an important goal. Intraoperative monitoring of myocardial metabolic state using continuous registration of nicotinamide adenine dinucleotide (NADH) and flavin adenine dinucleotide (FAD) fluorescence might contribute to the solution of the problem. The successful application of ...
McNamara R L RL Yale University School of Medicine, Cardiovascular Medicine, New Haven, CT, USA. Electronic address: - - 2014
To compare management of patients with acute non-ST segment elevation myocardial infarction (NSTEMI) in three developed countries with national ongoing registries. Results from clinical trials suggest significant variation in care across the world. However, international comparisons in "real world" registries are limited. We compared the use of in-hospital procedures and ...
Sasaki Naoko N Division of Cardiology, Department of Medicine, Nihon University School of - - 2014
Class III antiarrhythmic drugs have been shown to be effective for termination of atrial fibrillation (AF). The aim of this study was to determine the steady state and non-steady state effects of amiodarone and ibutilide on the atrial monophasic action potential (MAP) duration (MAPD), effective refractory period (ERP), and intra-atrial ...
Li Yulong Y Department of Medicine, Raritan Bay Medical Center, Perth Amboy, New Jersey, - - 2014
Psychosocial stress is one important risk factor for myocardial infarction. The study was to assess the impact of the 2008-2009 economic recession on myocardial infarction occurrences in different socioeconomic areas of Raritan Bay region, New Jersey. The patients, who were treated for acute myocardial infarction from January 2006 to June ...
Huber Kurt K 3rd Department of Medicine, Cardiology and Emergency Medicine, Wilhelminenhospital, Montleartstrasee 37, A-1160 Vienna, - - 2014
The organization of networks in order to better coordinate and to faster offer reperfusion strategies for acute ST-elevation myocardial infarction (STEMI) is an important recommendation of recent versions of international guidelines. This article focusses on similarities and dissimilarities of world-wide networks, highlights essential network components, offers insights into still unmet ...
Mallidi Hari R HR Department of Surgery, Baylor College of Medicine; and Center for Cardiac Support, Texas Heart Institute; Houston, Texas - - 2014
Mechanical circulatory support of the failing heart has become an important means of treating end-stage heart disease. This rapidly growing therapeutic field has produced impressive clinical outcomes and has great potential to help thousands of otherwise terminal patients worldwide. In this review, we examine the state of the art of ...
Lukachko Alicia A Mailman School of Public Health, Department of Epidemiology, Columbia University, - - 2014
There is a growing research literature suggesting that racism is an important risk factor undermining the health of Blacks in the United States. Racism can take many forms, ranging from interpersonal interactions to institutional/structural conditions and practices. Existing research, however, tends to focus on individual forms of racial discrimination using ...
Guglin Maya M University of South Florida, Tampa, FL, - - 2014
Inotrope use is one of the most controversial topics in the management of heart failure. While the heart failure community utilizes them and recognizes the state of inotrope dependency, retrospective analyses and registry data have overwhelmingly suggested high mortality, which is logically to be expected given the advanced disease states ...
Shrestha Nikesh Raj - - 2013
We present the case of an atypical presentation of myelofibrosis presenting with acute inferior-wall ST-elevation myocardial infarction. Besides cigarette smoking, the patient had no known traditional cardiovascular risk factors like diabetes, hypertension, or a sedentary lifestyle. He, however, had a hypercoagulable state due to a myeloproliferative neoplasm. This demonstrates that ...
Bice Justin S - - 2013
Guanylyl cyclase - cyclic guanosine monophosphate signalling plays an important role in endogenous cardioprotective signalling. The aim was to assess the potential of direct pharmacological activation and stimulation of soluble guanylyl cyclase, targeting different redox states of the enzyme, to limit myocardial necrosis during early reperfusion.Methods and ResultsRat isolated hearts ...
Bice Justin S - - 2013
Guanylyl cyclase - cyclic guanosine monophosphate signalling plays an important role in endogenous cardioprotective signalling. The aim was to assess the potential of direct pharmacological activation and stimulation of soluble guanylyl cyclase, targeting different redox states of the enzyme, to limit myocardial necrosis during early reperfusion.Methods and ResultsRat isolated hearts ...
Liepinsh Edgars - - 2013
A variety of calorie restriction diets and fasting regimens are popular among overweight people. However, starvation could result in unexpected cardiovascular effects. Therefore, it is necessary to evaluate the short-term effects of diets on cardiovascular function, energy metabolism and potential risk of heart damage in case of myocardial infarction. The ...
Shi Lihua - - 2013
The aim of this study was to examine the correlation between the microinflammatory state and structural and functional changes of the left ventricle in maintenance haemodialysis patients (MHD). In total, 48 MHD patients and 30 healthy volunteers participated in this study. The microinflammatory state was detected from high-sensitivity C-reactive protein ...
Bastings Maartje M C - - 2013
Minimally invasive intervention strategies after myocardial infarction use state-of-the-art catheter systems that are able to combine mapping of the infarcted area with precise, local injection of drugs. To this end, catheter delivery of drugs that are not immediately pumped out of the heart is still challenging, and requires a carrier ...
Garg Jalaj - - 2013
Antifibrinolytic agents, such as tranexamic acid (TA), aprotinin, and E-aminocaproic acid, have been extensively used in the past 2 decades to prevent blood loss from traumatic or postoperative bleeding. For example, the Clinical Randomization of an Antifibrinolytic in Significant Hemorrhage 2 (CRASH-2) trial demonstrated that there was a significant reduction ...
Kajimoto Masaki M Center for Developmental Therapeutics, Seattle Children's Research Institute, Seattle, WA, - - 2013
Extracorporeal membrane oxygenation (ECMO) supports infants and children with severe cardiopulmonary compromise. Nutritional support for these children includes provision of medium- and long-chain fatty acids (FAs). However, ECMO induces a stress response, which could limit the capacity for FA oxidation. Metabolic impairment could induce new or exacerbate existing myocardial dysfunction. ...
Whitson Bryan A - - 2013
The role of mechanical circulatory support for cardiopulmonary failure is expanding. Anticoagulation in the setting of static blood, hypercoagulable states, extracorporeal circuits, and surgery presents an intricate and delicate balance. We present a patient with large, biventricular thrombi during and succeeding biventricular mechanical support. Management of the thrombi and device ...
Blair John E A JE San Antonio Military Medical Center, San Antonio, TX, USA. - - 2013
Heart failure is a major health problem that affects patients and healthcare systems worldwide. Within the continent of North America, differences in economic development, genetic susceptibility, cultural practices, and trends in risk factors and treatment all contribute to both inter-continental and within-continent differences in heart failure. The United States and ...
Lavie Carl J CJ Department of Cardiovascular Diseases, John Ochsner Heart & Vascular Institute, Ochsner Clinical School, University of Queensland School of Medicine, New Orleans, Louisiana; Department of Preventive Medicine, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana. Electronic address: - - 2013
Obesity has reached epidemic proportions in the United States and worldwide. Considering the adverse effects of obesity on left ventricular (LV) structure, diastolic and systolic function, and other risk factors for heart failure (HF), including hypertension and coronary heart disease, HF incidence and prevalence, not surprisingly, is markedly increased in ...
Korley Frederick K - - 2013
It is only a matter of time before the use of high-sensitivity cardiac troponin assays (hs-cTn) becomes common throughout the United States. In preparation for this inevitability, this article raises a number of important issues regarding these assays that deserve consideration. These include: the need for the adoption of a ...
Sanderson Jennifer D M - - 2013
It was estimated that 785,000 new myocardial infarctions (MIs), 470,000 recurrent MIs, and 195,000 silent MIs will occur during 2010 in the United States. Cardiovascular disease, including heart disease and stroke, is the cause of death for 27% of Hispanic males and 31.5% of Hispanic females. There has been an ...
Rodriguez Limael E - - 2013
Ventricular assist devices are commonly utilized in the treatment of end-stage heart failure. Advances in continuous flow technology have improved efficiency, size, implantability, extended support, and overall patient outcomes. This has led to an expanded role of left ventricular assist device (LVAD) clinical use and applications. This review describes the ...
Lindenauer Peter K - - 2013
To examine the association between income inequality and the risk of mortality and readmission within 30 days of hospitalization. Retrospective cohort study of Medicare beneficiaries in the United States. Hierarchical, logistic regression models were developed to estimate the association between income inequality (measured at the US state level) and a ...
Yang Dong D Institute of Environmental Medicine, Division of Cardiovascular Epidemiology, Karolinska Institutet, Stockholm, - - 2013
To examine the relationship between sex, country of birth, level of education as an indicator of socioeconomic position, and the likelihood of treatment in a coronary care unit (CCU) for a first-time myocardial infarction. Nationwide register based study. Sweden. 199 906 patients (114 387 men and 85,519 women) of all ...
Acker Michael A - - 2012
The incorporation of complex medical device technologies into clinical practice is governed by critical oversight of the United States Food and Drug Administration. This regulatory process requires a judicious balance between assuring safety and efficacy, while providing efficient review to facilitate access to innovative therapies. Recent contrasting views of the ...
Vigen Rebecca R Division of Cardiology, University of Colorado School of Medicine, Aurora, CO 80045, USA. - - 2012
The United States population, particularly among older age groups, continues to expand. Because the incidence of heart failure increases with age, largely due to the development of heart failure risk factors such as hypertension and coronary artery disease, the epidemic of heart failure is likely to grow further in the ...
Simpson Christina - - 2012
Cardiovascular disease (CVD) is the leading cause of death in the United States. The goal of the national Million Hearts initiative is to prevent 1 million heart attacks and strokes by 2017 by promoting evidence-based preventive care and treatments for CVD. North Carolina has ongoing services and investments that will ...
Min James K - - 2012
To the Editor: Hoffmann et al. (July 26 issue)(1) conclude that, among patients with low-to-intermediate-risk acute coronary syndromes, the incorporation of coronary computed tomographic angiography (CCTA) improves the standard evaluation strategy.(2) However, it may be difficult to generalize their results, owing to different situations on the two sides of the ...
Dehmer Gregory J - - 2012
OBJECTIVES: To provide a report to the public of data from the CathPCI Registry of the National Cardiovascular Data Registry. BACKGROUND: The CathPCI Registry collects data from approximately 85% of the cardiac catheterization laboratories in the United States. METHODS: Data were summarized for 6 consecutive calendar quarters beginning January 1, ...
Groenendyk Jody - - 2012
The endoplasmic reticulum (ER) is a multifunctional intracellular organelle, a component of the cellular reticular network that allows cells to adjust to a wide variety of conditions. The cardiomyocyte reticular network is the ideal location of sensors for both intrinsic and extrinsic factors that disrupt energy and/or nutrient homeostasis and ...
Muñoz Daniel D Duke Clinical Research Institute, Duke University, Durham, NC 27705, USA. - - 2012
For patients with ST-segment elevation myocardial infarction transferred for primary percutaneous coronary intervention, guidelines have called for device activation within 90 minutes of initial presentation. Fewer than 20% of transferred patients are treated in such a timely fashion. We examine the association between transfer drive times and door-to-device (D2D) times ...
Kim Ha Won - - 2012
This study seeks to test our hypothesis that transgenic induction of miR-210 in mesenchymal stem cells (MSC) simulates the pro-survival effects of ischemic preconditioning (IPC) and that engraftment of (PC)MSC helps in the functional recovery of ischemic heart by miR-210 transfer to host cardiomyocytes through gap junctions. miR-210 expression in ...
Ko Wilson - - 2012
During the past 2 decades, percutaneous coronary intervention (PCI) has increased dramatically compared with coronary artery bypass grafting (CABG) for patients with coronary artery disease. However, although the evidence available to all practitioners is similar, the relative distribution of PCI and CABG appears to differ among hospitals and regions. We ...
Yuan Qiao-Ying - - 2012
AIMS: The aim of this study was to prove that an intramyocardial injection of a mixture of low-dose human growth factor (HGF) plasmid and microbubbles (MB) in combination with insonation was an effective therapy for myocardial infarction. MAIN METHODS: Twenty dogs with myocardial infarction were divided into 4 groups: (1) ...
Klein Norbert - - 2012
AimsElevated left ventricular (LV) pacing thresholds or phrenic nerve stimulation (PNS) might be possible reasons for absence of continuous and effective biventricular stimulation. This study investigated the benefit and clinical efficacy of the ability to choose one out of three different LV pacing vectors for the management of suboptimal LV ...
Johnson Lauren - - 2012
Most current indices of synchrony quantify left ventricular (LV) contraction pattern in terms of a single, global (integrated) measure. We report the development and physiological relevance of a novel method to quantify LV segmental contraction synchrony. LV pressure-volume and echocardiographic data were collected in seven anesthetized, opened-chest dogs under several ...
Prasad Konkal-Matt R KM Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22903, - - 2011
Localized administration of a highly efficient gene delivery system in combination with a cardiac-selective promoter may provide a favorable biosafety profile in clinical applications such as coronary artery bypass graft surgery, where regions of myocardium can be readily injected to protect them against the potential threat of future ischemic events. ...
McLeod Christopher J - - 2011
Patients with congenital heart disease and prosthetic valves frequently present management dilemmas related to cardiac pacing and lead placement. Permanent pacing of the right ventricle across a bioprosthetic tricuspid valve presents discreet issues related to its potential for traumatic injury and subsequent prosthetic valve dysfunction. Coronary sinus (CS) lead placement ...
Andreou A Y - - 2011
Isolated right ventricular infarction (RVI) is an increasingly recognized cause of precordial ST-segment elevation (STE). A patient is described who developed STE in leads V1-V5 secondary to occlusion of the right ventricular branch during stent angioplasty to the right coronary artery. The pattern of precordial STE was thought to be ...
Ueda Shinsaku - - 2011
We describe a rare case of successful repair of delayed cardiac rupture due to blunt chest trauma; the cardiac rupture occurred 74 days after the trauma. A 75-year-old woman with a history of blunt chest trauma that caused multiple rib fractures underwent an emergent thoracotomy due to left hemothorax. A ...
Ishikawa Kiyotake - - 2011
Various emerging technologies are being developed for patients with heart failure. Well-established preclinical evaluations are necessary to determine their efficacy and safety. Gene therapy using viral vectors is one of the most promising approaches for treating cardiac diseases. Viral delivery of various different genes by changing the carrier gene has ...
Jang Kyeong-Hee - - 2010
A 63-year-old female was presented to emergency room with an abdominal pain. The patient had moderate mitral valve stenosis and atrial fibrillation. Abdominal computed tomography revealed right renal infarction. Transthoracic echocardiography showed a large mobile mass in the left atrium. Transesophageal two-and three-dimensional echocardiography showed a large mobile ovoid mass ...
Russhard Paul - - 2011
Structural failure of mechanical heart valves is associated with a high mortality, especially when the valve is implanted in the aortic position. We describe a case of early intermittent dysfunction of a bileaflet mechanical heart valve implanted in a 67-year-old female. Transthoracic and transoesophageal echocardiography demonstrated intermittent jamming of the ...
Karlsson Lars O - - 2011
Eribis peptide 94 (EP 94) is a novel enkephalin analog, thought to interact with the μ- and δ-opioid receptors. The purpose of the present study was to examine the cardioprotective potential of EP 94 in two clinically relevant porcine models of myocardial ischaemia and reperfusion, and to investigate if such ...
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