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Results 351 - 400 of 939
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Lei Li - - 2008
Hypoxia-inducible transcription factor 1 (HIF-1) and HIF-2alpha regulate the expression of an expansive array of genes associated with cellular responses to hypoxia. Although HIF-regulated genes mediate crucial beneficial short-term biological adaptations, we hypothesized that chronic activation of the HIF pathway in cardiac muscle, as occurs in advanced ischemic heart disease, ...
Karmazyn Morris - - 2008
Na-H exchange (NHE) is the primary process by which the cardiac cell extrudes protons particularly under conditions of intracellular acidosis. Nine isoforms of NHE have now been identified. Although these antiporters are expressed in virtually all tissues, cardiac cells posses primarily the ubiquitous NHE-1 subtype. It has been well established ...
Bott-Flügel Lorenz - - 2008
Apoptosis--programmed cell death--has been implicated in a variety of cardiac diseases, including myocardial infarction and chronic heart failure. This study was conducted to quantify the amount of apoptotic markers in human end-stage heart failure and to correlate the results to clinical parameters of heart failure. Myocardial samples from 44 patients ...
Japp Alan G - - 2008
Apelin is the endogenous ligand for the previously orphaned G protein-coupled receptor, APJ. This novel peptidic signalling pathway is widely represented in the heart and vasculature, and is emerging as an important regulator of cardiovascular homeostasis. In preclinical models, apelin causes nitric oxide-dependent vasodilatation, reduces ventricular preload and afterload, and ...
Boonprasert Phitsanu - - 2008
Urocortins, a novel member of the corticotrophin-releasing factor (CRF) family, have been shown in animal and human studies to possess several beneficial effects in stress, cardiovascular and renal function, and inflammatory responses via CRF receptors. In the heart, urocortins have been demonstrated to produce cardioprotective effects during ischemia and reperfusion ...
Large Stephen - - 2008
This article describes the role of surgery in the management of acute presentations of heart failure. Intervention is set in the context of medical management. If the cause of the failure is not apparent this help is limited to mechanical support as intra-aortic balloon pumping, heart assistance or replacement. The ...
Ooi Henry - - 2008
Vascular load is an important determinant of ventricular function. This is particularly true of the failing heart, which is exquisitely load-sensitive. Vascular load comprises 2 major components: resistive load, which arises primarily at the arteriolar resistance vessels, and pulsatile load, which is primarily determined by aortic stiffness and early return ...
Bouchard Josée - - 2008
Dialytic therapies have undergone major technological developments in the last decade and emerging techniques are promoted not only for acute kidney injury, but also for sepsis, acute decompensated heart failure, and acute and acute-on-chronic liver failure. New devices specifically target the pathophysiological mechanisms involved in these conditions. In septic shock ...
Greyson Clifford R - - 2008
Right ventricular failure may be defined as the inability of the right ventricle of the heart to provide adequate blood flow through the pulmonary circulation at a normal central venous pressure. Critical care specialists encounter right ventricular failure routinely in their practice, but until recently right ventricular failure as a ...
Lukyanenko Valeriy - - 2007
Cardiovascular disease, including heart failure, is one of the leading causes of mortality in the world. Delivery of nano-objects as carriers for markers, drugs or therapeutic genes to cellular organelles has the potential to sharply increase the efficiency of diagnostic and treatment protocols for heart failure. However, cardiac cells present ...
Huddleston C B - - 2007
The Fontan procedure has been a significant contribution to the therapeutic armamentarium of congenital heart surgeons for the treatment of single ventricle anomalies. However, it has its limitations. Patients may have failure of the Fontan circulation acutely postoperatively or late during the long-term follow-up. Early failure is often related to ...
Hsu Ron-Bin - - 2007
BACKGROUND: Clinical outcome of heart transplantation in patients with heart failure and ascites has not been reported. Here, the clinical outcome of heart transplantation in patients with heart failure and ascites is evaluated. METHODS AND RESULTS: Between 1989 and 2005, 45 patients with heart failure and ascites underwent an orthotopic ...
Ismail Y - - 2007
Cardiac failure is a common medical presentation in Uganda. This study primarily focuses on the aetiology of heart failure in 65 adult patients and assesses the utility of echocardiography in a resource-limited setting. Our findings suggest that endomyocardial fibrosis is much less prevalent than previously described in other regions of ...
Tower Stephen S - - 2007
BACKGROUND: Studies have suggested that cross-linked polyethylene bearings reduce wear rates from 40% to 100% compared with conventional polyethylene. However, the reduced mechanical properties of highly cross-linked polyethylene have the potential to be a limiting factor in device performance. We reviewed a series of retrieved acetabular liners with a fracture ...
Pantos Constantinos - - 2007
OBJECTIVE: Previous experimental studies have provided evidence showing that changes in thyroid hormone signaling correspond to alterations in myocardial function in animal models of heart failure. The present study further explores whether thyroid hormone alterations are correlated with the functional status of the myocardium in patients with heart failure. METHODS: ...
Suh William M - - 2008
Restoring and maintaining optimal electrical activation of the cardiac chambers as well as atrioventricular synchrony are important aspects of heart failure management. The 12-lead electrocardiogram remains a simple and cost-effective diagnostic tool that can provide important clues in achieving this goal. We report a case where careful interpretation of the ...
Furnary Anthony P - - 2007
BACKGROUND: Aprotinin is frequently used in high-risk cardiac surgery patients to decrease bleeding complications and transfusions of packed red blood cells (PRBC). Transfusions of PRBC are known to directly increase the risk of new onset postoperative renal failure (ARF) in cardiac surgery patients. A recent highly publicized report implicated aprotinin ...
Guglin Maya - - 2007
Managing volume overload is essential for the treatment of symptomatic heart failure. Traditionally, it is achieved with oral and intravenous diuretics. Alternatively, the excess fluid can be removed via ultrafiltration. Modern technology has made this latter option more feasible than before for routine clinical practice. In this article we review ...
Kline Kay Setter - - 2007
This study examined the effects of 2 home healthcare nursing approaches--supportive-educative and mutual goal setting--on self-management for patients with heart failure. Both approaches are specifically related to participants' understanding of heart failure and self-efficacy in managing the condition. An experimental, longitudinal, repeated-measures design was used with a sample of 88 ...
Cavallari Larisa H - - 2007
Cardiac fibrosis plays an important role in the pathophysiology of heart failure. The authors sought to determine whether biomarkers of cardiac fibrosis for milder clinical degrees of heart failure are comparable to those of more advanced disease. Procollagen types I and III amino-terminal peptides (PINP and PIIINP) and type I ...
Mosterd Arend - - 2007
The aim of this paper is to review the clinical epidemiology of heart failure. The last paper comprehensively addressing the epidemiology of heart failure in Heart appeared in 2000. Despite an increase in manuscripts describing epidemiological aspects of heart failure since the 1990s, additional information is still needed, as indicated ...
de Korte M A - - 2007
Trastuzumab can induce cardiotoxicity, particularly when combined with anthracyclines. Myocardial human epidermal growth factor receptor 2 (HER2) expression may be transiently upregulated by a compensatory mechanism following cardiac stress. 111In-DTPA-trastuzumab, scintigraphy can detect HER2 positive tumour lesions, however previously, we found myocardial uptake in only 1 of the 15 anthracycline-pre-treated ...
Balakumar, Pitchai
Heart failure is associated with high morbidity and mortality and is proving to be an economic burden in developing countries. A number of therapeutic agents are presently employed in heart failure; but they are not sufficient to control symptoms of heart failure. Moreover, the prevalence of chronic heart failure is ...
Mannheimer Buster - - 2007
OBJECTIVE: To study the validity and reliability of the new disease-specific extension of the CHP, Cardiac Health Profile congestive heart failure (CHPchf), used to assess QoL specifically for patients with heart failure. METHODS: Eighty-three consecutive patients with chronic heart failure were enrolled. Criteria and construct validity were studied by correlating ...
Erdmann Erland - - 2007
OBJECTIVE: PROspective pioglitAzone Clinical Trial In macroVascular Events (PROactive) enrolled patients with type 2 diabetes and preexisting cardiovascular disease. These patients were at high risk for heart failure, so any therapeutic benefit could potentially be offset by risk of associated heart failure mortality. We analyzed the heart failure cases to ...
Lockhart C J - - 2008
BACKGROUND: We present two clinical cases from a single institution where a final diagnosis of cardiac failure was made following the initial finding of ascites and an elevated CA 125 level. In both cases gynaecological malignancy was initially suspected. METHODS: Following negative confirmatory tests for gynaecological malignancy, echocardiography was undertaken. ...
Brack Thomas - - 2007
BACKGROUND: Cheyne-Stokes respiration (CSR) frequently occurs in patients with severe heart failure during sleep and may increase mortality. Daytime CSR supposedly poses an even greater risk, but its prevalence and prognostic importance remain elusive. Therefore, we investigated the circadian prevalence of CSR and its influence on survival in patients with ...
Conca Cristina - - 2008
BACKGROUND: Real-time 3-dimensional echocardiography (RT3DE) to visualize the coronary sinus (CS) was compared with multislice cardiac tomography (MSCT). METHODS: In all, 37 consecutive patients undergoing MSCT received RT3DE a few hours later. Group A (n = 22) had normal left ventricular dimension/function, whereas group B (n = 15) had heart ...
Kostin Sawa - - 2007
Focal disorganization of gap junctional distribution and down-regulation of the major gap junctional protein connexin 43 are typical features of myocardial remodelling in the failing human heart. Increasing evidence indicates that connexin 43 interacts with zonula-occludens-1 (ZO-1), and it has recently been shown that ZO-1 promotes the formation and growth ...
Sica Domenic A - - 2007
Thiamine, or vitamin B1, is a water-soluble B complex vitamin that was first discovered in 1910 in the process of exploring how rice bran cured patients of beriberi. Thiamine is not synthesized in humans, therefore its availability for necessary cellular processes hinges on its continual ingestion. The amount of thiamine ...
Brigadeau François - - 2007
It has been reported that high intramyocardial peroxisome proliferator-activated receptor alpha (PPARalpha) stimulation or overexpression altered cardiac contractile function in mouse models of cardiac hypertrophy and heart failure. Nevertheless, it has never been demonstrated that clinically relevant doses of drugs stimulating PPARalpha activity such as fenofibrate increase the risk to ...
El-Armouche Ali - - 2007
Cardiac myosin-binding protein-C (cMyBP-C) is an important regulator of cardiac contractility, and its phosphorylation by PKA is a mechanism that contributes to increased cardiac output in response to beta-adrenergic stimulation. It is presently unknown whether heart failure alters cMyBP-C phosphorylation. The present study determined the level of phosphorylated cMyBP-C in ...
Davidson Patricia M - - 2007
BACKGROUND: Patients with heart failure have higher mortality rates than those with most malignant diseases. The heart failure illness trajectory is one of gradual decline characterized by unpredictable events such as acute decompensation of heart failure or a sudden cardiac death. Health professionals have an obligation to give patients and ...
Olkowski A A - - 2007
Modern strains of fast-growing meat type poultry are highly susceptible to heart failure. Heart-related mortalities are observed predominantly in fast-growing broiler chickens, with ascites and sudden death syndrome being the most common heart-related conditions in modern broiler flocks. This paper examines the role of structural, molecular, and biochemical factors pertinent ...
Abdel-Qadir Husam M - - 2007
PURPOSE OF REVIEW: The purpose of this review is to summarize the recent literature regarding the familial heritability of heart failure and to discuss the possible mechanisms through which this risk is mediated. RECENT FINDINGS: Data from the Framingham Heart Study recently showed that the parental occurrence of heart failure ...
Mahmud Mobusher - - 2007
Right heart failure most commonly results from the complication of left heart failure (systolic or nonsystolic dysfunction) or pulmonary hypertension. Over the past decade, greater attention has been paid to the role of right ventricular failure in the morbidity and mortality associated with cardiomyopathy and pulmonary hypertension. The right ventricle ...
Moore Brian - - 2007
Oxygen consumption (VO2) has previously been used for prognosis and risk stratification in patients with heart failure. More recent research has introduced VE/VCO2 slope as a prognostic measure. Risk of mortality is thought to increase when VE/VCO2 slope values are greater than 34. Therefore, the purpose of this study was ...
Shroff Gautam R - - 2007
The magnitude of burden imposed by heart failure on society has necessitated the evolution of innovative strategies to identify specific avenues of treatment and the populations at highest risk. Multiple studies have demonstrated a higher burden of cardiovascular disease in black Americans. It has also been shown that the clinical ...
Bursi Francesca - - 2007
BACKGROUND: There is a paucity of data on the prognostic role of C-reactive protein (CRP) measured after myocardial infarction. We prospectively examined the association of CRP with heart failure and death among patients with myocardial infarction in the community. METHODS AND RESULTS: All Olmsted County residents who had a myocardial ...
Olkowski A A - - 2007
In order to explain the biochemical mechanisms associated with deteriorating heart function in broiler chickens, this study compared myocardial high energy phosphate substrates in leghorns, feed restricted (Broilers-Res) broilers, ad libitum fed broilers (Broilers-AL), and in broilers that developed heart failure and ascites. The profile of adenine nucleotide content in ...
Townsend DeWayne - - 2007
Duchenne muscular dystrophy (DMD) is a fatal disease of striated muscle deterioration resulting from the loss of the cytoskeletal protein dystrophin. Most patients develop significant cardiomyopathy, with heart failure being the second leading cause of death in DMD. Compared with the extensive studies on skeletal muscle defects and potential therapy ...
Ho Yi-Lwun - - 2007
BACKGROUND/PURPOSE: The influence of home- and clinic-based caring system on the economic burden of heart failure remains unknown. METHODS: Between January 2004 and December 2004, chronic heart failure patients who were followed up by specialist nurse-led telephone visiting regularly were enrolled. Clinical and economic data half a year before enrollment ...
Lipina Radim - - 2007
INTRODUCTION: Late failure of originally successful endoscopic third ventriculostomy (ETV) is considerably less common than failure of ventriculo-peritoneal (V-P) shunt in treatment of hydrocephalus. Death in consequence of late ETV failure is a very rare complication, so far having been mentioned in literature in 13 patients only. CASE REPORT: We ...
Ho Hee Hwa - - 2008
We described a patient who presented with symptoms of heart failure and was found to have diastolic heart failure. Several investigations pointed to the diagnosis of constrictive pericarditis which was later confirmed by cardiac catheterisation. The etiology turns out to be primary cardiac lymphoma which is extremely rare in immunocompetent ...
Laing James G - - 2007
BACKGROUND: Reduced expression of the major gap junction protein connexin 43 (Cx43) in the failing human heart may lead to arrhythmias and sudden cardiac death. Cx43 interacts with the actin binding protein, zonula occludens-1 (ZO-1), and it has recently been demonstrated that ZO-1 regulates the formation and function of Cx43 ...
Roberts Felicia - - 2007
OBJECTIVE: To examine the evidence regarding the safety of metformin in heart failure. DATA SOURCES: Searches in MEDLINE and International Pharmaceutical Abstracts were performed (1966-February 2007). Search terms included metformin, heart failure, lactic acidosis, clinical trials, and insulin resistance. STUDY SELECTION AND DATA EXTRACTION: Published studies and case reports that ...
Brack Thomas - - 2007
Cheyne-Stokes respiration (CSR) during the day and at night is common in patients with severe heart failure. CSR harms the failing heart through recurrent sympathetic overstimulation caused by sleep disturbances and intermittent hypoxia brought about by apnoea and hypopnoea. CSR impairs patients' quality of life and wakefulness, and probably also ...
Birmingham C L - - 2007
OBJECTIVE: To report the presentation and causes of heart failure complicating anorexia nervosa (AN). METHOD: Report of a case of heart failure occurring in a patient with AN and a review of the literature. RESULTS: A 56 year old woman with a 25 year history of AN binge-purge subtype experienced ...
Gott Merryn - - 2007
OBJECTIVES: To explore dying trajectories in heart failure. DESIGN: Prospective, longitudinal study. SETTING: Sixteen GP surgeries in four demographically contrasting areas of the UK. PARTICIPANTS: A total of 27 heart failure patients, >60 years of age, who completed questionnaires for at least five time-points before death. MAIN OUTCOME MEASURES: Kansas ...
Welch William C - - 2007
Anterior cervical plate (ACP) failure is rarely addressed in the literature. In this retrospective, observational, longitudinal, cohort study, the objectives were to (1) identify incidences of in vivo biomechanical failure in commercially available, US Food and Drug Administration-approved ACP systems, (2) describe modes of failure, (3) suggest structural explanations for ...
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