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Lotz Christopher C From the Department of Physiology, Division of Cardiology, University of California, Los Angeles, Los Angeles, - - 2014
Isoflurane has been demonstrated to limit myocardial ischemic injury. This effect is hypothesized to be mediated in part via effects on mitochondria. We investigated the hypothesis that isoflurane maintains mitochondrial respiratory chain functionality, in turn limiting mitochondrial damage and mitochondrial membrane disintegration during myocardial ischemic injury. Mice (9-12 weeks of ...
Luo Ke-Qin KQ Emergency Department, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen Univeristy, Guangzhou, 510210, Guangdong, China, - - 2014
To observe the effect of simvastatin in patients with acute myocardial infarction in rabbits against myocardial apoptosis, and to explore its possible mechanism. Male New Zealand white rabbits were randomized into three groups, including the myocardial infarction group (12 rabbits), the simvastatin treatment group (15 rabbits), and the sham group ...
Ali-Hassan-Sayegh Sadegh S Cardiovascular Research Center, Afshar Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran - - 2014
This systematic review with meta-analysis sought to determine the efficacy and safety of intramyocardial transplantation of bone marrow stem cells during coronary artery bypass graft surgery on postoperative cardiac functional parameters such as left ventricular ejection fraction and left ventricular end-diastolic volume. Medline/PubMed, Embase, Elsevier, Sciences online database, and Google ...
Ge Tong T Department of Respiratory Medicine, the Second Hospital of Harbin, Harbin, 150000, P.R. - - 2014
This study aimed to investigate the effects of thoracic epidural anesthesia (TEA) on cardiac function and myocardial cell apoptosis in isoproterenol (ISO) induced chronic heart failure (CHF) rats. Rats were classified into 4 groups: the healthy control, ISO-induced CHF, ISO + TEA, and sham-treated groups. After 4 weeks, the animals in each ...
Müller Julia J Institut für Pharmakologie und Klinische Pharmakologie, Universitätsklinikum der Heinrich-Heine-Universität Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, - - 2014
Interleukin-6 (IL-6) is a multifunctional cytokine that orchestrates the immune response to a wide variety of pathophysiologic challenges but also contributes to tissue homeostasis. Furthermore, IL-6 is elevated in patients with acute myocardial infarction. Hyaluronan (HA) is an extracellular carbohydrate that has been implicated in wound healing and accumulates after ...
Panda Nikhil C NC Heart & Vascular Research Center, MetroHealth Campus of Case Western Reserve University, 2500, MetroHealth Drive, Rammelkamp, 6th floor, Cleveland, OH, 44109-1998, - - 2014
Mesenchymal stem cells (MSCs) have been associated with reduced arrhythmias; however, the mechanism of this action is unknown. In addition, limited retention and survival of MSCs can significantly reduce efficacy. We hypothesized that MSCs can improve impulse conduction and that alginate hydrogel will enhance retention of MSCs in a model ...
Ren-An Qin Q Guangzhou General Medicine & Pharmaceutical Research Institute, Guangzhou, P.R. - - 2014
Compound Danshen Tablet (CDT), an herbal preparation consisting of Salvia miltiorrhiza (Radix and rhizome of Salvia miltiorrhiza Bge.), Notoginseng (Radix and rhizome of Panax notoginseng (Burk.) F. H. Chen) and Borneolum Syntheticum, is widely used to improve coronary heart disease, cardiac angina and atherosclerosis in clinic in Asia and Pacific ...
Brandenburger Timo - - 2014
BackgroundRemote ischemic preconditioning (RIPC) protects the heart from ischemia and reperfusion (I/R) injury. The underlying molecular mechanisms are unclear. It has been demonstrated that Connexin 43 (Cx43) is critically involved in cardioprotective interventions including classical ischemic preconditioning. In the present study we investigated the influence of RIPC on the expression ...
Bakrania Bhavisha B Griffith - - 2014
Mildly elevated circulating unconjugated bilirubin (UCB) is associated with protection against hypertension and ischemic heart disease. We assessed whether endogenously elevated bilirubin in Gunn rats modifies cardiovascular function and resistance to ischemic insult. Hearts were assessed ex vivo (Langendorff perfusion) and in vivo (Millar catheterization, echocardiography), and left ventricular myocardial ...
Chiari Pascal P From the Department of Anesthesiology and Critical Care (P.C., O.D., O.B., J.-J.L.), Clinical Investigation Center (N.M., M.O.), Department of Cardiology (N.M., M.O.), and Department of Cardiothoracic Surgery (J.-F.O., J.R., F.F., O.J.), Centre Hospitalier Universitaire Louis Pradel, Lyon, France; Lyon University, Inserm U1060, CarMeN Laboratory, Univ Lyon-1, Lyon, France (P.C., N.M., J.-F.O., O.J., M.O.); and Department of Cardiology, Centre Hospitalier Universitaire de Tours and EA 4245 François Rabelais University, Tours, France - - 2014
Part of the myocardial damage occurring during cardiac surgery is a consequence of reperfusion injury. Cyclosporine, a potent inhibitor of the opening of the mitochondrial permeability transition pore, attenuates reperfusion injury in patients with acute ST-segment elevation myocardial infarction. This study investigated whether the administration of cyclosporine just before the ...
Acar Rezzan Deniz RD Cardiology Department, Kartal Kosuyolu Education and Research Hospital, Istanbul, - - 2014
The main aim of this study was to detect the possible early effect of cardiac rehabilitation (CR) on left atrium (LA) and left ventricle (LV) function and relation to aortic stiffness in patients with acute myocardial infarction (AMI). Fifty-four patients with AMI were enrolled in this study. Left atrial strain ...
Mahimarangaiah Jayaranganath J 1Department of Cardiology,Sri Jayadeva Institute of Cardiovascular Sciences and - - 2014
Background: To study the feasibility and complications associated with the use of ductal occluders for closure of perimembranous ventricular septal defects. Methods: A total of 126 patients, ranging from 1 to 41 years of age (median - 8 years), underwent closure of ventricular septal defects from August 2010 to April ...
Sauer Andrew J AJ Division of Cardiology, Northwestern University Feinberg School of - - 2014
Aortic insufficiency (AI) following rotary left ventricular assist device (LVAD) implantation is an increasingly common problem with inadequately defined treatment options. Percutaneous transcatheter (PTC) closure of the aortic valve has been described as a potential non-surgical approach. Alternatively, we present a case of decompensated heart failure due to de novo ...
Kidher Emaddin - - 2014
Cardiac function and myocardial strain are affected by cardiac afterload, which is in part due to the stiffness of the aortic wall. In this study, we hypothesize that aortic pulse wave velocity (PWV) as a marker of aortic stiffness correlates with conventional clinical and biochemical markers of cardiac function and ...
Lindman Brian R BR Washington University School of Medicine, St. Louis, Missouri. Electronic address: - - 2014
This study sought to examine the relationship between left ventricular mass (LVM) regression and clinical outcomes after transcatheter aortic valve replacement (TAVR). LVM regression after valve replacement for aortic stenosis is assumed to be a favorable effect of LV unloading, but its relationship to improved clinical outcomes is unclear. Of ...
Lee Seung-Pyo SP Department of Internal Medicine and Cardiovascular Center, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, - - 2014
Although rarefaction of myocardial angiogenesis has been shown to be associated with left ventricular (LV) systolic dysfunction in animal models of ventricular hypertrophy, this relationship has not been investigated in depth nor validated in humans. We aimed to analyze the relationship of myocardial angiogenesis with various functional and structural ventricular ...
Swamy Pooja P Department of Cardiology, Loma Linda University Medical Center, Loma Linda, - - 2014
Tetralogy of Fallot (TOF) is a cyanotic heart disease consisting of nonrestrictive ventricular septal defect, overriding aorta, pulmonary stenosis, and right ventricular hypertrophy. Early total correction is the treatment of choice and these patients with repaired TOF are increasingly seen in adult practice. This review addresses echocardiographic evaluation of TOF, ...
Chin Calvin Wl CW BHF/Centre for Cardiovascular Science, University of Edinburgh, 49 Little France Crescent, Edinburgh, EH16 4SB, - - 2014
Calcified aortic stenosis is a condition that affects the valve and the myocardium. As the valve narrows, left ventricular hypertrophy occurs initially as an adaptive mechanism to maintain cardiac output. Ultimately, the ventricle decompensates and patients transition towards heart failure and adverse events. Current guidelines recommend aortic valve replacement in ...
Grieco D D Department of Cardiology, Institute for Clinical and Experimental Medicine, Videnska 1958/9, 140 21, Prague 4, Czech - - 2014
We present a case of a patient who, after correction of tetralogy of Fallot (TOF), experienced runs of ventricular tachycardia (VT). Mapping of the aortic root showed that the critical component of the reentry was located within the noncoronary cusp. The potential explanations of such an unusual isthmus location may ...
Phadke Milind S MS Department of Cardiology, Seth Gordhandas Sunderdas Medical College and King Edward Memorial Hospital, Mumbai, Maharashtra, - - 2014
Transcatheter closure of a large hypertensive patent ductus arteriosus is challenging with scant data about it. Even more challenging is retrieval of an embolized Amplatzer duct occluder. We report successful closure of a 12 mm large ductus with the Amplatzer muscular VSD occluder (post myocardial infarction) after percutaneous retrieval of ...
Hirose Tomoaki T Department of Thoracic and Cardiovascular Surgery, Nara Medical University School of Medicine, Nara, - - 2014
Left ventricular noncompaction is a rare cardiac pathology that results from an arrest in endomyocardial development in early embryogenesis. With great advances in imaging modalities, this pathological entity has been noted not only in the pediatric population but also in adults. Herein we report the case of a 62-year-old woman ...
Bil Jacek J Department of Invasive Cardiology, Central Clinical Hospital of the Ministry of Interior, Warsaw, - - 2014
The aim of this study was to assess prospectively the effectiveness and safety profile of distal left main stem (LMS) stenosis treatment with dedicated bifurcation paclitaxel-eluting stent BiOSS Expert®. Angioplasty of distal LMS stenosis is always a high-risk procedure, and optimal treatment is uncertain. This was a prospective international 2-center ...
Roscani Meliza G MG 1Univ Est. Paulista - Botucatu Medical School - - - 2014
Background: Although an increased left ventricular (LV) diastolic diameter (DD) and a decreased ejection fraction (EF) have been used as markers for the surgical replacement of an insufficient aortic valve, these signals may be observed when irreversible myocardium damage has already occurred. The aim of this study was to determine ...
Kodera Satoshi S Department of Cardiovascular Medicine, Asahi General Hospital, I-1326 Asahi, Chiba, 289-2511, Japan, - - 2014
We report a 71-year-old woman with inferior acute myocardial infarction (AMI) due to type A acute aortic dissection. Emergency enhanced computed tomography (CT) did not show obvious aortic dissection. During emergency percutaneous coronary intervention (PCI), intravascular ultrasonography revealed type A aortic dissection. Hemodynamic stability was restored after PCI. 1 month later, ...
Perez-Negueruela Carolina C Department of Pediatric Cardiac Surgery, Sant Joan de Deu Hospital, Barcelona, - - 2014
We report a case of a patient who presented with aortic stenosis and a borderline left ventricle during foetal life. A balloon aortic valve valvuloplasty was performed in uterus, and in the postnatal period for relief of the left ventricular outflow tract obstruction followed by a Ross-Konno procedure with fibroelastosis ...
Klug G G University Clinic of Internal Medicine III, Cardiology, Innsbruck Medical University, Anichstrasse 35, A-6020 Innsbruck, - - 2014
Aortic pulse wave velocity (PWV) was linked to LV-geometry and -function in patients with kidney disease and non-ischemic cardiomyopathy. The role of aortic compliance after acute STEMI is so far unknown. In the present study, we prospectively investigated the relationship of increased aortic stiffness with biomarkers of myocardial wall stress ...
Avsar Mustafa K MK Department of Cardiolovascular Surgery, Medicana International Hospital, Beylikdüzü, Istanbul, Turkey, - - 2014
Abnormal communication between the ascending aorta and the cardiac chambers is rare, diverse in origin, and can be congenital or acquired. We report a case of a 10-year-old boy with acquired aorta-to-left atrial fistula associated with an air gun pellet injury and his successful treatment.
Elhmidi Yacine Y Clinic for Cardiovascular Surgery, German Heart Center, Munich, 80636, Germany. - - 2014
Aortic stenosis patients with left ventricular dysfunction are at increased risk for morbidity and mortality following surgical aortic valve replacement. There are few published data regarding the outcomes of patients with severe aortic stenosis and left ventricular (LV) dysfunction undergoing transcatheter aortic valve implantation (TAVI) and possible predictors of LV ...
Ouss Alexandre J AJ Department of Cardiology, Onze Lieve Vrouwe Gasthuis Hospital, Amsterdam, the - - 2014
A distinct velocity pattern represented by a "notch" is observed during the time interval between the end of the systolic and the onset of the early diastolic velocity wave on longitudinal myocardial velocity curve. The origin of the post-systolic velocity notch (PSN) has not been resolved. The high frame rate ...
Dusenbery Susan M SM Department of Cardiology, Boston Children's Hospital, and the Department of Pediatrics, Harvard Medical School, Boston, - - 2014
We analyzed cardiac magnetic resonance (CMR) measurements of myocardial extracellular volume fraction (ECV) and late gadolinium enhancement (LGE) in children and young adults with congenital aortic stenosis (AS) to determine the extent of fibrosis and examine their association with aortic valve and ventricular function. Patients with congenital AS frequently have ...
Nakajima Seiko S Department of Transplantation, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, Osaka, 565-8565, - - 2014
Despite continual improvements in ventricular assist device (VAD) therapy, various clinical issues are emerging. Importantly, various types of thromboembolic complications have been reported to date. Recently, we encountered a rare continuous-flow VAD-related thromboembolic event that resulted in acute myocardial infarction. A 26-year-old female who just underwent HeartMate II(®) VAD implantation ...
Summaria Francesco F Interventional Cardiology, Policlinico Casilino, Via Casilina 1049, 00169 Rome, - - 2014
Intra-aortic balloon pump counterpulsation is currently the most used mechanical assistance device for patients with cardiogenic shock due to acute myocardial infarction. However, a recently published meta-analysis and trial failed to confirm previous knowledge. We report the results of four patients with ST elevation myocardial infarction, complicated by cardiogenic shock ...
Roberts William C WC Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, Texas; Department of Pathology, Baylor University Medical Center, Dallas, Texas; Division of Cardiology, Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas. Electronic address: - - 2014
Described herein are clinical and necropsy findings in a 61-year-old woman with fatal left ventricular diastolic failure secondary to massive calcific deposits primarily within the left ventricular cavity. At age 3, an isthmic aortic coarctation was resected, and at age 44, a stenotic congenitally bicuspid aortic valve was replaced. The cause of ...
Park Ji Young JY Department of Internal Medicine, Division of Cardiology, Eulji General Hospital, Eulji University, Seoul, - - 2014
The aim of this study is to investigate the relationship of inflammation, myocardial fibrosis, and cardiac remodeling in patients with mild aortic stenosis (AS) as assessed by biomarkers and echocardiography. We consecutively evaluated 32 patients with mild AS and thirty age and gender matched, healthy individuals with normal aortic valves ...
Majak P P Department of Cardiothoracic Surgery Oslo University Hospital, Ullevål, Oslo, Norway - - - 2014
Aim: Visfatin may play a part in reverse left ventricular remodelling. Using a mouse model of reversible left ventricle pressure overload, we examined if visfatin was altered in the myocardium. Furthermore, we addressed this issue in patients with aortic stenosis (AS) and examined whether visfatin levels are related to reverse ...
Hajj-Chahine Jamil J Department of Cardiothoracic Surgery, University Hospital of Poitiers, Poitiers, France. Electronic address: - - 2014
We describe the case of a 57-year-old woman with noncompaction of the left ventricle and regurgitant bicuspid aortic valve who presented with progressive congestive heart failure and was successfully treated with aortic root replacement. The long-term outcome for these patients is poor because of progressive left ventricular impairment, increased rates ...
Talwar Sachin S Cardiothoracic Centre, All India Institute of Medical Sciences, New Delhi, - - 2014
We report an unusual cause of failure of successful delivery of antegrade cardioplegia through the aortic root that was caused by the accidental passage of the left ventricular vent catheter across the aortic valve producing acute aortic regurgitation. This problem is best prevented.
Fana Xi-Zhen XZ Department of Cardiology, Anhui Provincial Hospital , 17 Lujiang Road Luyang District, Hefei, Anhui Province, 230001, P. R. - - 2014
This study aims to observe the effects of doxycycline (DOX) on gap junction remodeling after MI and the susceptibility of rats to cardiac arrhythmia. The proximal left anterior descending coronary artery of rats was ligated to establish a myocardial infarction animal model. DOX, methylprednisolone (MP), or vehicle was intraperitoneally injected ...
Wen Zhili Z Department of Infectious Disease, Nanchang University Medical School, Nanchang, Jiangxi, China; Department of Pathology and Lab Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio, United States of - - 2014
MicroRNAs have been appreciated in various cellular functions, including the regulation of angiogenesis. Mesenchymal-stem-cells (MSCs) transplanted to the MI heart improve cardiac function through paracrine-mediated angiogenesis. However, whether microRNAs regulate MSC induced angiogenesis remains to be clarified. Using microRNA microarray analysis, we identified a microRNA expression profile in hypoxia-treated MSCs ...
Furenes Eline Bredal EB Center for Clinical Heart Research, Department of Cardiology, Oslo University Hospital Ullevål, Postboks 4956, Nydalen, 0424 Oslo, Norway ; Center for Heart Failure Research, Institute for Experimental Medical Research, Ullevål University Hospital, Kirkeveien 166, 0407 Oslo, Norway ; Faculty of Medicine, University of Oslo, Postboks 1078, Blindern, 0316 Oslo, - - 2014
Background. Matrix metalloproteinase-9 (MMP-9), regulated by tissue inhibitor of metalloproteinase-9 (TIMP-1) and the extracellular matrix metalloproteinase inducer (EMMPRIN), contributes to plaque instability. Autologous stem cells from bone marrow (mBMC) treatment are suggested to reduce myocardial damage; however, limited data exists on the influence of mBMC on MMPs. Aim. We investigated ...
Zhang Jian J Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of - - 2014
Chronic myocardial infarction (MI) results in the formation of arrhythmogenic substrates, causing lethal ventricular arrhythmia (VA). We aimed to determine whether mesenchymal stem cells (MSCs) carrying a hepatocyte growth factor (HGF) gene modification (HGF-MSCs) decrease the levels of arrhythmogenic substrates and reduce the susceptibility to developing VA compared with unmodified ...
Li Liang L First Department of Cadres, First Hospital Affiliated to General Hospital of People's Liberation Army, Beijing, - - 2014
Myocardial infarction (MI) is one of the leading causes of death worldwide and Mesenchymal Stem Cells (MSCs) transplantation has been considered a promising therapy. Recently, it was reported that the therapeutic effectiveness of MSCs is dependent on the age of the donor, yet the underlying mechanism has not been thoroughly ...
Song Rong R Department of Intensive Care Unit, The Fifth Hospital of PLA Yinchuan 750004, Ningxia, P. R. - - 2014
This study aims to explore the expression and significance of ATPase in myocardium of congestive heart failure induced by pressure overload in rats. Male SD rats were divided into 3 groups randomly: Control group (C group), coarctation of abdominal aorta 15 weeks group (A group) and sham operation group (SH ...
Luszczak Joanna - - 2013
Early detection of left ventricle (LV) systolic dysfunction is essential for management of patients with aortic stenosis (AS). Two- dimensional speckle tracking derived global longitudinal peak strain (GLPS) is more sensitive than ejection fraction (EF) but requires good image quality and is not easily accessible. The aim of the study ...
Ribichini Flavio F Department of Medicine, the University of Verona, Verona, - - 2013
Left ventricular assistance with surgically implanted pump devices like the HeartMate may be crucial in selected patient with end-stage heart failure. However, mainly due to its high aortic output, the pump itself may induce severe aortic regurgitation that could result in paradoxycal worsening of the anterograde perfusion after the initiation ...
Shim Jae-Kwang JK Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Yonsei University Health System, Seoul, South - - 2013
Unexpected and reversible causes of ventricular dysfunction requiring a prompt second surgical procedure to restore the cardiac function should always be sought before the initiation of positive inotropic support. We report a case of obstruction of the right coronary ostium by an organized thrombus that had migrated retrogradely from the ...
Sirin Selma S Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Hufelandstrasse 55, 45147, Essen, Germany, - - 2013
Previous studies showed the reliability of cardiac magnetic resonance imaging (cMRI) in the quantification of aortic valve stenosis in adults. The aim of this retrospective study was to assess the ability of cMRI in the quantification of congenital aortic valve stenosis (CAS) in children. Nineteen patients (mean age 14.0 ± 3.2 years, 15 ...
Ciçek Omer F OF Department of Cardiology, Ankara Ataturk Education and Research Hospital, Ankara, - - 2013
Capable of multi-organ involvement in Sjogren's syndrome (SS), cardiac findings of pulmonary effusion, left ventricular diastolic dysfunction and pulmonary hypertension are seen in patients with SS. Aortic stiffness (AS) reflects the mechanical tension and elasticity of the aorta. In this study, our aim is to determine if there is any ...
Takemoto Kazushi K Department of Medicine, Wakayama Medical University, Wakayama, - - 2013
The aim of this study was to test whether acceleration time of systolic coronary flow velocity could contribute to the diagnosis of coronary stenosis in patients with microvascular dysfunction, on the basis of the hypothesis that systolic coronary flow is less influenced by microvascular function because of compressed myocardium. Coronary ...
Karmonik Christof C Methodist DeBakey Heart & Vascular Center, Houston Methodist Hospital, Houston, Tex. Electronic address: - - 2013
Increased use of continuous-flow left ventricular assist devices for long-term mechanical support necessitates a better understanding of hemodynamic changes in the native heart and the ascending aorta. By using patient-specific computational models, correlations of potentially adverse hemodynamic conditions with the orientation of the left ventricular assist device outflow graft and ...
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