Search Results
Results 1 - 50 of 2807
1 2 3 4 5 6 7 8 9 10 >
Kesdangsakonwut S S Laboratory of Comparative Pathology, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, - - 2014
Cardiomyopathies have been rarely described in rabbits. Here we report myocardial necrosis of the ventricular wall in rabbits with experimentally induced rabies. Myocardial lesions were found only in rabbits with brain lesions, and the severity of the cardiac lesions was proportional to that of the brain lesions. Neither the frequency ...
Cinca Juan J Department of Cardiology, Hospital de la Santa Creu i Sant Pau, Institute of Biomedical Research IIB Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain. Electronic address: - - 2014
Acute myocardial ischemia in opposite regions may attenuate the ST-segment changes but whether this effect is expressed differently in extracardiac compared to direct intramyocardial recordings, is not well known. To characterize ST-segment changes induced by opposite ischemic regions in intact and isolated perfused pig hearts. Left anterior descending (LAD) and ...
Gao Yan Y Department of Pharmacology, Shanghai University of Traditional Chinese Medicine, NO. 1200 Cailun Road, Shanghai, 201203, - - 2014
To examine the effects of houttuynin on ventricular remodeling induced by coronary artery ligation in rats and the underlying mechanisms. A rat model of ventricular remodeling was established by left coronary artery ligation (CAL). Rats were randomly divided into four groups: CAL control, CAL plus 40mg/kg captopril, CAL plus 100mg/kg ...
Atalay Figen - - 2014
Cardiac toxicity is one of the life-threatening complications of cancer therapy. Systemic anticancer treatments may exert their own toxic effects or can aggravate adverse effects of other drugs. We report a case of cyclophosphamide-induced cardiotoxicity in a patient with normal cardiac functions before chemotherapy. A 66-year-old Caucasian woman with a ...
Santoro Francesco F Cardiology Department, University of Foggia, Foggia, - - 2014
We report coronary angio findings of very late (10-year) coronary spasm inducing acute myocardial infarction with typical chest pain in a heart transplant recipient. Coronary spasm was promptly relieved by intra-coronary infusion of nitrates.
Benoist David D Multidisciplinary Cardiovascular Research Centre, University of Leeds, UK; L'Institut de Rythmologie et Modelisation Cardiaque, INSERM U1045, Université de Bordeaux, - - 2014
We demonstrate the synergistic benefits of using multiple technologies to investigate complex multi-scale biological responses. The combination of reductionist and integrative methodologies can reveal novel insights into mechanisms of action by tracking changes of in vivo phenomena to alterations in protein activity (or vice versa). We have applied this approach ...
Der Sarkissian S S Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM); Faculty of Medicine, Department of Surgery, Université de - - 2014
Celastrol, a natural triterpene from plant extracts, has been used in traditional oriental medicine to treat various diseases. In this study we investigate the cardioprotective effects of Celastrol against ischemia. Protective pathways induced by Celastrol were investigated in H9c2 rat cardiomyoblast hypoxic cultures and in a rat model of myocardial ...
Li Yan Y Division of Histology & Embryology, Key Laboratory for Regenerative Medicine of the Ministry of Education, Medical College, Jinan University, Guangzhou 510632, - - 2014
The developing embryo is very sensitive to oxidative stress and excess reactive oxygen species (ROS) generation is often associated with cardiovascular malformation. However, little is known about the adverse effects of ROS during heart morphogenesis, especially during the formation of the atria and ventricles. We have treated early chick embryos ...
Fang Fang F Division of Cardiology, Department of Medicine and Therapeutics, Institute of Vascular Medicine; Institute of Innovative Medicine; HEART Center; and Li Ka Shing Institute of Health Sciences, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong; Beijing AnZhen Hospital, Capital Medical University, - - 2014
Right ventricular (RV) pacing may affect myocardial perfusion and coronary blood flow; however, it remains unknown whether this is related to systolic dyssynchrony induced by RV pacing. This prospective study was aimed to assess the relationship between dyssynchrony and the changes of coronary blood flow. Seventy patients with sinus node ...
Zhou Zhi-Wen ZW Department of Cardiology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, P.R. - - 2014
The purpose of this study was to explore the feasibility of continuous remote monitoring, and the induction and termination of malignant ventricular arrhythmias (VAs) by a novel implantable electronic cardiovascular device (IECD) system in rabbits with myocardial infarction (MI). The IECD was implanted and MI was induced by ligation of ...
Zhou Su-Feng SF Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, 430022, - - 2014
Inflammatory responses play an important role in the pathogenesis of adverse ventricular remodeling after myocardial infarction (MI). We previously demonstrated that interleukin (IL)-17A plays a pathogenic role in myocardial ischemia/reperfusion injury and viral myocarditis. However, the role of IL-17A in post-MI remodeling and the related mechanisms have not been fully ...
Wang Jiangyou J Department of Cardiology, the First Affiliated Hospital of Guangxi Medical University, Nanning, - - 2014
Background/Aims: Growing evidence shows that phosphatase and tensin homolog deleted on chromosome ten (PTEN) is involved in regulating inflammation in different pathological conditions. Therefore, we hypothesized that the upregulation of PTEN correlates with the impairment of cardiac function in swine following coronary microembolization (CME). Methods: To possibly disclose an anti-inflammatory ...
Roca-Alonso L L Imperial College London, National Heart and Lung Institute (NHLI), London, United - - 2014
The use of anthracyclines such as doxorubicin (DOX) has improved mortality and morbidity in cancer patients, yet associated risks of cardiomyopathy have limited their clinical application. DOX-associated cardiotoxicity is frequently irreversible and typically progresses to heart failure (HF). However, our understanding of molecular mechanisms essential for development of cardioprotective strategies ...
Parapanov R R University Hospital Centre Vaudois (CHUV), Department of Intensive Care Medicine and Burns, Lausanne, - - 2014
Inflammatory processes play a key role in the pathophysiology of myocardial infarction (MI). Genetic deletion of toll-like recpetors (TLRs), especially TLR2 and TLR4 have shown protective role in murine models of MI. The role of other TLRs remains unknown. We have previously shown that cardiomyocytes express TLR5 and that the ...
Kovacs M M University of Szeged, Department of Pharmacology and Pharmacotherapy, Szeged, - - 2014
We have now examined whether the ischaemia-induced structural alterations of the main gap junction (GJ) protein connexin43 (Cx43) are modified by rapid cardiac pacing, 24h previously. Under light pentobarbital anesthesia, in 8 dogs a pacing electrode was introduced into the right ventricle through which, in half of these dogs, the ...
Varga Zv Z Semmelweis University, Department of Pharmacology and Pharmacotherapy, Budapest, - - 2014
We aimed to characterize early changes in microRNA expression in acute cardioprotection by ischemic pre- and postconditioning in rat hearts. Hearts isolated from male Wistar rats were subjected to i) time-matched non-ischemic perfusion, ii) ischemia/reperfusion (30 min coronary occlusion and 120 min reperfusion), iii) preconditioning (3x5 min coronary occlusion) followed ...
Ciobanu L L Institute of Cardiology, Chisinau, Moldova, Republic - - 2014
in vitro evaluation of the isolated aorta rings and coronary reactivity of isovolimic heart in fluorine induced on rat heart defeat (FHD). The control and FHD (water with NaF 0,3% during 7 weeks,) isolated aorta rings and isovolumic heart were perfused by Krebs solution. The phenylephrine induced aorta constrictor plateau ...
Li M M University of Turin, Molecular Biotechnology and Health Sciences, Turin, - - 2014
Phosphoinositide 3-kinase γ (PI3Kγ) signaling is pivotal in the regulation of myocardial contractility and remodeling. We demonstrated previously that inhibition of PI3Kγ lipid kinase activity limits cardiac inflammation and improves contractile function in pressure overload-induced heart failure. Here we intend to investigate whether PI3Kγ inhibition is beneficial in chemotherapy-induced cardiomyopathy. ...
Abdul Ghani S S University of Bristol, Bristol, United - - 2014
Remote ischemic preconditioning (RIPC) induced by brief ischemia/reperfusion (I/R) cycles of remote organ (e.g. limb) is cardio-protective. The myocardial cellular changes during RIPC that are responsible for this phenomenon are not currently known. However, it is widely accepted that unlike classical ischemic preconditioning, RIPC does not induce ischemic stress in ...
Rani N N All India Institute of Medical Sciences (AIIMS), PHARMACOLOGY, New Delhi, - - 2014
Chrysin (5,7-dihydroxylflavone), an agonist of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) has been shown to possess antioxidant and anti-inflammatory properties. Here, we investigated whether chrysin (60 mg/kg/day) can improve the pathophysiology of myocardial infarction in diabetes partially through the PPAR-gamma pathway by assessing a variety of indices, e.g., hemodynamic, biochemical, histoarchitectural ...
Hofmann Ulrich U University of Wuerzburg, University Clinic, Comprehensive Heart Failure Center, Department of Internal Medicine I, Würzburg, Germany - - 2014
-Activation of innate immunity, especially infiltration of monocytes, is critical for proper wound healing and scar formation after myocardial infarction (MI). Therefore, we tested the hypothesis that interleukin-13 (IL-13), which influences the differentiation of monocytes/ macrophages and has pro-fibrotic properties, modulates wound healing and remodelling after myocardial infarction. -MI was ...
Y-Hassan Shams S Karolinska Institute at Karolinska University Hospital, Department of Cardiology , Stockholm , - - 2014
Background and objectives: Myocardial depression in the setting of sepsis and septic shock is common and has been recognized for a long time. The aim of this study is to find out an association and causal link between sepsis and takotsubo syndrome (TS). Methods: Fifteen cases of TS were studied. ...
Khan Muhammad F - - 2014
Newly developed antineoplastic drugs have resulted in improvements in morbidity and mortality from many forms of cancers. However, some of these new chemotherapeutic agents have potentially lethal side effects, which are now being exposed with their widespread use. Gemcitabine is a nucleoside analog, which is a commonly used agent for ...
Riede Florian F Electrophysiology/Cardiology, University of Basel Hospital, Basel, - - 2014
An 18-year-old male with a history of symptomatic tachycardia was referred for ablation. The ECG (Panel A) showed preexcitation suggestive of a posteroseptal accessory pathway. Orthodromic AV-reentry tachycardia (ORT) with a wide right bundle branch block (RBBB) pattern was inducible (Panel B). This article is protected by copyright. All rights ...
Rana A A Cardiovascular Division, Department of Pharmacology, I.S.F College of Pharmacy, Moga-142001, Punjab, - - 2014
Myocardial infarction is a pathological state which occurs due to severe abrogation of the blood supply (ischemia) to a part of heart, which can cause myocardial damage. The short intermittent cycles of sub-lethal ischemia and reperfusion has shown to improve the tolerance of the myocardium against subsequent prolonged ischemia/reperfusion (I/R)-induced ...
Agrawal Yogeeta Y Department of Pharmaceutical Sciences,Jaipur National University, Jagatpura, Jaipur-302017, India; Department of Pharmacology, All India Institute of Medical Sciences, New Delhi-110029, India; Department of Pharmacology, R.C.Patel Institute of Pharmaceutical Education and Research, Shirpur-425405, Maharashtra, - - 2014
Hesperidin has been shown to possess cardioprotective and anti-diabetic potential. Hitherto, its molecular mechanism on isoproterenol (ISO)-induced myocardial dysfunction in diabetes is still not explored. Hence, for the first time we sought to investigate whether hesperidin exerts any beneficial effect on the pathophysiology of myocardial infarction (MI) in diabetes through ...
Cudnoch-Jedrzejewska A A Department of Experimental and Clinical Physiology, Medical University of Warsaw, Pawinskiego str 3c, 02-106 Warsaw, Poland. Electronic address: - - 2014
Chronic mild stress (CMS) and myocardial infarction (MI) induce anhedonia, which is one of the symptoms of depression. The purpose of this study was to determine the role of the central V1 vasopressin receptors (V1R) in post-CMS and post-MI anhedonia. To this end, we investigated the effect of blockage the ...
Bonatti Rodolfo R Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil; Beth Israel Deaconess Medical Center, Boston, - - 2014
Ischemic heart disease is associated with dual risk for atrial and ventricular arrhythmias. We examined whether selectively targeting late INa with GS-458967 can reduce cardiac electrical instability and compared its effects to a clinically relevant dose of flecainide. Electrode catheters were positioned on left atrial appendage and left ventricle of ...
Song Rui R Department of Prevention, Tongji University School of Medicine, Shanghai, - - 2014
Myocardial hypertrophy that often leads to eventual heart failure is a leading cause of mortality worldwide. While both apoptosis and cell proliferation have been reported to play an important part in heart failure, its exact triggering mechanism is still unclear. Reports have shown that low concentrations of H2O2 (10-30 µM) can ...
Luedde Mark M Internal Medicine III: Cardiology and Angiology, University of Kiel, - - 2014
Programmed necrosis (necroptosis) represents a newly identified mechanism of cell death combining features of both apoptosis and necrosis. Like apoptosis, necroptosis is tightly regulated by distinct signalling pathways. A key regulatory role in programmed necrosis has been attributed to interactions of the receptor interacting kinases RIP1 and RIP3. However, the ...
Eijsvogels Thijs M H TM Henry Low Heart Center, Department of Cardiology, Hartford Hospital, Hartford, Connecticut; Department of Physiology, Radboud University Medical Center, Nijmegen, The - - 2014
Marathon running commonly causes a transient elevation of creatine kinase and cardiac troponin I (cTnI). The use of statins before marathon running exacerbates the release of creatine kinase from skeletal muscle, but the effect of statin use on exercise-induced cTnI release is unknown. We therefore measured cTnI concentrations in statin-using ...
Birnbaum Yochai Y The Section of Cardiology, Baylor College of Medicine, Houston, TX, USA; Texas Heart Institute, Baylor St. Luke's Medical Center, Houston, TX, USA. Electronic address: - - 2014
Left ventricular hypertrophy (LVH) induces changes in the depolarization and repolarization of the heart that alter the resting electrocardiogram (ECG). These changes include widening of the QRS duration, an increase in the QRS amplitude and secondary changes in the ST segment and T waves. Typically, there is ST segment depression ...
Raj Shashi S Department of Pediatrics, Division of Pediatric Cardiology, University of Miami Miller School of Medicine, Miami, FL, - - 2014
Anthracyclines have been widely used in children and adults to treat hematologic malignancies, soft-tissue sarcomas, and solid tumors. However, anthracyclines come with both short- and long-term cardiotoxic effects, ranging from occult changes in myocardial structure and function to severe cardiomyopathy and heart failure that may result in cardiac transplantation or ...
- - 2014
Corticosteroids have been shown to reduce short-term mortality during septic shock and therefore recommended in the most severe patients as adjuvant therapy. Until recently, recombinant human activated protein C (APC) was also considered in the management of more severe cases. As myocardial depression has long been recognized as a manifestation ...
Zhang Guoru G Department of Cardiovascular Disease, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050005, - - 2014
It is desirable to minimize the risk of adverse radiation effects associated with percutaneous coronary intervention. The aim of this study was to determine the impact of prolonging the interval between coronary angiography and percutaneous coronary intervention on X-ray-induced DNA double-strand breaks in blood lymphocytes using γ-H2AX immunofluorescence microscopy. Blood ...
Lujan Heidi L HL Department of Physiology, Wayne State University School of Medicine, Detroit, 48201, - - 2014
Reperfusion-induced lethal ventricular arrhythmias are observed during relief of coronary artery spasm, with unstable angina, exercise-induced ischemia, and silent ischemia. Accordingly, significant efforts are underway to understand the mechanisms responsible for reperfusion-induced lethal arrhythmias and mice have become increasingly important in these efforts. However, although reperfusion-induced sustained ventricular tachycardia leading ...
Xiao Cang-Song CS Department of Cardiovascular Surgery, Institute of Cardiac Surgery, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing 100853, - - 2014
To establish a cost-effective and reproducible procedure for induction of chronic left ventricular aneurysm (LVA) in rabbits. Acute myocardial infarction (AMI) was induced in 35 rabbits via concomitant ligation of the left anterior descending (LAD) coronary artery and the circumflex (Cx) branch at the middle portion. Development of AMI was ...
Ghanbari Hamid H Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, - - 2014
-Although ventricular tachycardia (VT) ablation is a widely used therapy for patients with VT, the ideal endpoints for this procedure are not well defined. We performed a meta-analysis of the published literature to assess the predictive value of non-inducibility of post-infarction VT for long-term outcomes after VT ablation. -We performed ...
Zholobenko A A Department of Medical Chemistry and Biochemistry, School of Medicine and Dentistry, Palacky University, HnÄ›votínská 3, Olomouc, 77515, Czech - - 2014
Silymarin, a standardised extract of Silybum marianum (milk thistle), comprises mainly of silybin, with dehydrosilybin (DHSB), quercetin, taxifolin, silychristin and a number of other compounds which are known to possess a range of salutary effects. Indeed, there is evidence for their role in reducing tumour growth, preventing liver toxicity, and ...
Gautier Sophie - - 2014
Granulocyte colony-stimulating factor (G-CSF) is a pharmacologic agent inducing neutrophil mobilization and a new candidate for neuroprotection and neuroregeneration in stroke. Its effects when used in combination with tissue plasminogen activator (tPA) were explored during the acute phase of ischemic stroke. We used a middle cerebral artery occlusion (MCAO) model ...
Sahu Bidya Dhar BD Medicinal Chemistry and Pharmacology Division, CSIR-Indian Institute of Chemical Technology (IICT), Hyderabad, 500 007, - - 2014
Myocardial oxidative stress leading to apoptosis and remodeling is the major consequence of ischemic heart disease. In the present study, we investigated the effect of Lagerstroemia speciosa L. leave (LS) extract containing 1 % corosolic acid in the context of cardiovascular disorder by using isoproterenol (ISO)-induced myocardial injury mouse model. Serum ...
Varga Zoltán V ZV Semmelweis - - 2014
We aimed to characterize early changes in microRNA expression in acute cardioprotection by ischemic pre- and postconditioning in rat hearts. Hearts isolated from male Wistar rats were subjected to i) time-matched non-ischemic perfusion, ii) ischemia/reperfusion (30 min coronary occlusion and 120 min reperfusion), iii) preconditioning (3x5 min coronary occlusion) followed ...
Gandhi Sumeet S McMaster University, Division of Cardiology, Hamilton, ON, - - 2014
Contrast-induced acute kidney injury is an adverse outcome resulting from radiocontrast medium exposure during coronary angiography and percutaneous coronary intervention. A systematic search was conducted to retrieve studies that investigated the impact of statin exposure prior to coronary angiography and/or percutaneous coronary intervention on the development of contrast-induced acute kidney ...
Volo Samuel C SC Greenberg Cardiology Division, Department of Medicine, Weill Cornell Medical College, New York, New - - 2014
Mitral regurgitation (MR) is common with coronary artery disease as altered myocardial substrate can affect valve performance. Single-photon emission computed tomography myocardial perfusion imaging (MPI) enables assessment of myocardial perfusion alterations. This study examined perfusion pattern in relation to MR. A total of 2,377 consecutive patients with known or suspected ...
Börekçi Abdurrezzak A Department of Cardiology, School of Medicine, Kafkas University, Kars, - - 2014
Reactive oxygen species have been implicated in the pathogenesis of contrast-induced nephropathy (CIN). We investigated the relationship between CIN with paraoxonase 1 (PON-1) activity and oxidative stress markers (total antioxidant status [TAS], total oxidant status [TOS], and oxidative stress index [OSI]) in patients with anterior ST-segment elevation myocardial infarction (STEMI) ...
Silberbauer John J Arrhythmia Unit and Electrophysiology Laboratories, Ospedale San Raffaele, Milan, - - 2014
-Successful late potential (LP) abolition and post-procedural ventricular tachycardia (VT) non-inducibility constitute significant endpoints after catheter ablation for VT. We investigated the prognostic impact of a combined procedural endpoint of VT non-inducibility and LP abolition in a large series of post-myocardial infarction (MI) patients with VT. -160 (154 male, 94% ...
Yamazaki Katrina Go KG California State University Los Angeles, Department of Biological Sciences, Los Angeles, CA, United States; University of California San Diego, United States. Electronic address: - - 2014
Targeting the mitochondria during ischemia/reperfusion (IR) can confer cardioprotection leading to improved clinical outcomes. The cardioprotective potential of (-)-epicatechin (EPI) during IR via modulation of mitochondrial function was evaluated. Ischemia was induced in rats via a 45min occlusion of the left anterior descending coronary artery followed by 1h, 48h, or ...
Ke Tingyu T Department of Endocrinology, the Second Affiliated Hospital, Kunming Medical University,, Kunming, China ; - - 2014
Aim: Netrin-1 is typically known as a neuronal guidance factor. Studies later reported pro-angiogenenic, anti-apoptotic and anti-inflammatory properties of Netrin-1. A critical role of Netrin-1 in ischaemic organ damages, myocardiac infarction (MI) in particular, was also demonstrated, making Netrin-1 a potential therapeutic target for cardiovascular diseases. Mesenchymal stem cells (MSCs) ...
Ussher John R JR Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, - - 2014
GLP-1R agonists improve outcomes in ischemic heart disease. Here we studied GLP-1R-dependent adaptive and cardioprotective responses to ventricular injury. Glp1r (-/-) hearts exhibited chamber-specific differences in gene expression, but normal mortality and left ventricular (LV) remodeling after myocardial infarction (MI) or experimental doxorubicin-induced cardiomyopathy. Selective disruption of the cardiomyocyte GLP-1R ...
Edmondson E F EF Flint Animal Cancer Center, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, - - 2014
Pheochromocytoma-associated catecholamine-induced cardiomyopathy is a well-known entity in man, nonhuman primates, and mice but has not been described in dogs. In this retrospective study, 9 dogs were identified with pheochromocytomas and concurrent cardiovascular pathology observed histologically (n = 6), echocardiographically (n = 4), and/or electrocardiographically (n = 5). Cardiac lesions ...
1 2 3 4 5 6 7 8 9 10 >