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Buchholz Bruno B Institute of Cardiovascular Physiopathology, Department of Pathology, Faculty of Medicine, University of Buenos Aires and Institute of Biochemistry and Molecular Medicine (IBIMOL), J. E. Uriburu 950 - 2nd floor. C1114AAD, Buenos Aires, - - 2014
In a previous research, we described that vagal stimulation increases the infarct size by sympathetic co-activation. The aim of this study was to determine if hemodynamic changes secondary to the vagal stimulation are able to activate sympathetic compensatory neural reflexes, responsible for increasing the infarct size. A second goal was ...
Sulkin Matthew S MS - - 2014
Instability of the inner mitochondrial membrane potential (ΔΨm) has been implicated in electrical dysfunction, including arrhythmogenesis during ischemia/reperfusion. Monitoring ΔΨm has led to conflicting results, where depolarization has been reported as sporadic and as a propagating wave. This study was designed to resolve the aforementioned differences and determine the unknown ...
Silvetti Massimo Stefano MS Arrhythmia Unit and Syncope Unit, Department of Paediatric Cardiology, Bambino Gesù Children's Hospital, IRCCS, Via Torre di Palidoro 1, 00050 Palidoro-Rome, Italy - - 2014
Right ventricular (RV) pacing may induce left ventricular (LV) dysfunction: neonates and infants with isolated congenital complete/advanced atrioventricular block (CCAVB) are at high risk of developing RV pacing-induced LV dyssynchrony, remodelling, and dysfunction. We prospectively investigated whether LV pacing results in normal LV function and good clinical status in the ...
Thakkar Jay B JB Westmead Hospital & Sydney Medical School, University of Sydney, Sydney, - - 2014
-Inducible Ventricular tachycardia (VT) is a strong predictor of spontaneous ventricular tachyarrhythmia following ST elevation myocardial infarction (STEMI). Reduced left ventricular ejection fraction (LVEF) predisposes patients to inducible ventricular tachycardia post STEMI. However the role of right ventricular (RV) dysfunction in predisposing to inducible VT has not been described previously. ...
Guill Antonio A ITACA, Universitat Politècnica de València, Valencia, España. Electronic address: - - 2014
Abnormal QT interval durations and dispersions have been associated with increased risk of ventricular arrhythmias. The present study examines the possible arrhythmogenic effect of inducing QT interval variations through local epicardial cooling and warming. In 10 isolated rabbit hearts, the temperatures of epicardial regions of the left ventricle were modified ...
Saeed Diyar D Clinic for Cardiovascular Surgery, Heinrich-Heine University of Düsseldorf, Düsseldorf, Germany. Electronic address: - - 2014
Suction events are among the frequently encountered issues after the implantation of a left ventricular assist device and may induce malignant arrhythmias. Several factors may play a role in inducing these suction events. A proper inflow cannula insertion site at the time of surgery, particularly in hypertrophic left ventricles, plays ...
Lee Teresa E TE Duke - - 2014
Activated/uninhibited calcineurin is both necessary and sufficient to induce cardiac hypertrophy, a condition that often leads to dilated cardiomyopathy, heart failure, and sudden cardiac death. We expressed constitutively active calcineurin in the adult heart of Drosophila melanogaster and identified enlarged cardiac chamber dimensions and reduced cardiac contractility. In addition, expressing ...
Itou Junji J Department of Genetics, Cell Biology & Development, University of Minnesota; Department of Stem cell institute, University of - - 2014
Background: The zebrafish heart regenerates after various severe injuries. Common processes of heart regeneration are cardiomyocyte proliferation, activation of epicardial tissue and neovascularization. In order to further characterize heart regeneration processes, we introduced milder injuries and compared responses to those induced by ventricular apex resection, a widely used injury method. ...
Frommeyer Gerrit G Division of Electrophysiology, Department of Cardiovascular Medicine, University of Münster, Münster, Germany. Electronic address: - - 2014
The present ESC guidelines on atrial fibrillation have introduced vernakalant (VER) for pharmacological cardioversion of atrial fibrillation. Therefore, the aim of the present study was to investigate possible proarrhythmic effects of vernakalant in an experimental model of heart failure (HF). In twelve female rabbits, HF was induced by 4 weeks ...
Packard René R S RR Department of Medicine (Cardiology), University of California, Los Angeles, California; - - 2014
Absolute quantitation of myocardial blood flow (MBF) by PET is an established method of analyzing coronary artery disease (CAD) but subject to the various shortcomings of available radiotracers. Flurpiridaz F 18 is a novel PET radiotracer that exhibits properties of an ideal tracer. A new absolute perfusion quantitation method with ...
Huang Bing B Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, - - 2014
Renal sympathetic nerve (RSN) activity plays a key role in systemic sympathetic hyperactivity. Previous studies have shown that cardiac sympathetic hyperactivity, especially the left stellate ganglion (LSG), contributes to the pathogenesis of ventricular arrhythmias (VAs) after acute myocardial infarction (AMI). Twenty-eight dogs received 3h of continuous left-sided electrical stimulation of ...
Wang Zhiqiang Z Department of Thoracic and Cardiovascular Surgery, Affiliated Hospital of Jiangnan University, The Fourth People's Hospital of Wuxi City, Wuxi, People's Republic of - - 2014
Video-assisted thoracic surgery (VATS) has been widely applied in the treatment of lung cancer. However, few studies have focused on the clinical factors predicting the major postoperative complications. Clinical data from 525 patients who underwent resection of primary lung cancer with VATS from January 2007-August 2011 were retrospectively analyzed. Risk ...
Siu Kin Lung KL Divisions of Molecular Medicine and Cardiology, Department of Anesthesiology, Cardiovascular Research Laboratories, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA; Divisions of Molecular Medicine and Cardiology, Department of Medicine, Cardiovascular Research Laboratories, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, - - 2014
Despite an established role of mitochondrial dysfunction in cardiac ischemia reperfusion (I/R) injury, the upstream activators have remained incompletely defined. We have recently identified an innovative role of exogenously applied netrin-1 in cardioprotection, which is mediated by increased nitric oxide (NO) bioavailability. Here, we tested the hypothesis that this "pharmacological" ...
Kesdangsakonwut S S Laboratory of Comparative Pathology, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, - - 2014
Cardiomyopathies have been rarely described in rabbits. Here we report myocardial necrosis of the ventricular wall in rabbits with experimentally induced rabies. Myocardial lesions were found only in rabbits with brain lesions, and the severity of the cardiac lesions was proportional to that of the brain lesions. Neither the frequency ...
Arrebola-Moreno Antonio Luis AL Unidad de Hemodinámica, Servicio de Cardiología, Hospital Universitario Virgen de las Nieves, Granada, Spain; Cardiovascular and Cell Sciences Research Institute, St. George's, University of London, London, - - 2014
Impaired coronary microvascular dilatory function can lead to exercise induced myocardial ischemia and angina pectoris even in patients without significant (>50%) obstructive coronary atherosclerosis (APWOCA). Diffuse distal vessel epicardial spasm and microvascular spasm have been also proposed as a plausible explanation for angina at rest in these patients. However, objective ...
Cinca Juan J Department of Cardiology, Hospital de la Santa Creu i Sant Pau, Institute of Biomedical Research IIB Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain. Electronic address: - - 2014
Acute myocardial ischemia in opposite regions may attenuate the ST-segment changes but whether this effect is expressed differently in extracardiac compared to direct intramyocardial recordings, is not well known. To characterize ST-segment changes induced by opposite ischemic regions in intact and isolated perfused pig hearts. Left anterior descending (LAD) and ...
Gao Yan Y Department of Pharmacology, Shanghai University of Traditional Chinese Medicine, NO. 1200 Cailun Road, Shanghai, 201203, - - 2014
To examine the effects of houttuynin on ventricular remodeling induced by coronary artery ligation in rats and the underlying mechanisms. A rat model of ventricular remodeling was established by left coronary artery ligation (CAL). Rats were randomly divided into four groups: CAL control, CAL plus 40mg/kg captopril, CAL plus 100mg/kg ...
Atalay Figen - - 2014
Cardiac toxicity is one of the life-threatening complications of cancer therapy. Systemic anticancer treatments may exert their own toxic effects or can aggravate adverse effects of other drugs. We report a case of cyclophosphamide-induced cardiotoxicity in a patient with normal cardiac functions before chemotherapy. A 66-year-old Caucasian woman with a ...
Santoro Francesco F Cardiology Department, University of Foggia, Foggia, - - 2014
We report coronary angio findings of very late (10-year) coronary spasm inducing acute myocardial infarction with typical chest pain in a heart transplant recipient. Coronary spasm was promptly relieved by intra-coronary infusion of nitrates.
Benoist David D Multidisciplinary Cardiovascular Research Centre, University of Leeds, UK; L'Institut de Rythmologie et Modelisation Cardiaque, INSERM U1045, Université de Bordeaux, - - 2014
We demonstrate the synergistic benefits of using multiple technologies to investigate complex multi-scale biological responses. The combination of reductionist and integrative methodologies can reveal novel insights into mechanisms of action by tracking changes of in vivo phenomena to alterations in protein activity (or vice versa). We have applied this approach ...
Der Sarkissian S S Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM); Faculty of Medicine, Department of Surgery, Université de - - 2014
Celastrol, a natural triterpene from plant extracts, has been used in traditional oriental medicine to treat various diseases. In this study we investigate the cardioprotective effects of Celastrol against ischemia. Protective pathways induced by Celastrol were investigated in H9c2 rat cardiomyoblast hypoxic cultures and in a rat model of myocardial ...
Li Yan Y Division of Histology & Embryology, Key Laboratory for Regenerative Medicine of the Ministry of Education, Medical College, Jinan University, Guangzhou 510632, - - 2014
The developing embryo is very sensitive to oxidative stress and excess reactive oxygen species (ROS) generation is often associated with cardiovascular malformation. However, little is known about the adverse effects of ROS during heart morphogenesis, especially during the formation of the atria and ventricles. We have treated early chick embryos ...
Fang Fang F Division of Cardiology, Department of Medicine and Therapeutics, Institute of Vascular Medicine; Institute of Innovative Medicine; HEART Center; and Li Ka Shing Institute of Health Sciences, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong; Beijing AnZhen Hospital, Capital Medical University, - - 2014
Right ventricular (RV) pacing may affect myocardial perfusion and coronary blood flow; however, it remains unknown whether this is related to systolic dyssynchrony induced by RV pacing. This prospective study was aimed to assess the relationship between dyssynchrony and the changes of coronary blood flow. Seventy patients with sinus node ...
Zhou Zhi-Wen ZW Department of Cardiology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, P.R. - - 2014
The purpose of this study was to explore the feasibility of continuous remote monitoring, and the induction and termination of malignant ventricular arrhythmias (VAs) by a novel implantable electronic cardiovascular device (IECD) system in rabbits with myocardial infarction (MI). The IECD was implanted and MI was induced by ligation of ...
Pothiawala S E SE Department of Emergency Medicine, Singapore General Hospital, - - 2014
Hyperkalemia is an acute life-threatening disorder presenting to the emergency department. Patients with hyperkalemia may manifest characteristic electrocardiographic changes including tented T waves, widening of the QRS complex and loss of P waves, sine wave pattern and eventually asystole. There have been only few reports of hyperkalemia causing ST segment ...
Chakraborty Manodeep M Department of Pharmacology, Bhagwant University, Ajmer, Rajasthan, - - 2014
Globally, the rate of development of myocardial diseases and hypertension is very common, which is responsible for incremental morbidity and mortality statistics. Treatment of ischemic hypertensive patients with diuretics such as hydrochlorothiazide (HCTZ) can precipitate myocardial infarction due to hypokalemia. This study was undertaken to evaluate the pharmacodynamic interaction of ...
Zhou Su-Feng SF Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, 430022, - - 2014
Inflammatory responses play an important role in the pathogenesis of adverse ventricular remodeling after myocardial infarction (MI). We previously demonstrated that interleukin (IL)-17A plays a pathogenic role in myocardial ischemia/reperfusion injury and viral myocarditis. However, the role of IL-17A in post-MI remodeling and the related mechanisms have not been fully ...
Wang Jiangyou J Department of Cardiology, the First Affiliated Hospital of Guangxi Medical University, Nanning, - - 2014
Background/Aims: Growing evidence shows that phosphatase and tensin homolog deleted on chromosome ten (PTEN) is involved in regulating inflammation in different pathological conditions. Therefore, we hypothesized that the upregulation of PTEN correlates with the impairment of cardiac function in swine following coronary microembolization (CME). Methods: To possibly disclose an anti-inflammatory ...
Hofmann Ulrich U University of Wuerzburg, University Clinic, Comprehensive Heart Failure Center, Department of Internal Medicine I, Würzburg, Germany - - 2014
-Activation of innate immunity, especially infiltration of monocytes, is critical for proper wound healing and scar formation after myocardial infarction (MI). Therefore, we tested the hypothesis that interleukin-13 (IL-13), which influences the differentiation of monocytes/ macrophages and has pro-fibrotic properties, modulates wound healing and remodelling after myocardial infarction. -MI was ...
Y-Hassan Shams S Karolinska Institute at Karolinska University Hospital, Department of Cardiology , Stockholm , - - 2014
Background and objectives: Myocardial depression in the setting of sepsis and septic shock is common and has been recognized for a long time. The aim of this study is to find out an association and causal link between sepsis and takotsubo syndrome (TS). Methods: Fifteen cases of TS were studied. ...
Khan Muhammad F - - 2014
Newly developed antineoplastic drugs have resulted in improvements in morbidity and mortality from many forms of cancers. However, some of these new chemotherapeutic agents have potentially lethal side effects, which are now being exposed with their widespread use. Gemcitabine is a nucleoside analog, which is a commonly used agent for ...
Riede Florian F Electrophysiology/Cardiology, University of Basel Hospital, Basel, - - 2014
An 18-year-old male with a history of symptomatic tachycardia was referred for ablation. The ECG (Panel A) showed preexcitation suggestive of a posteroseptal accessory pathway. Orthodromic AV-reentry tachycardia (ORT) with a wide right bundle branch block (RBBB) pattern was inducible (Panel B). This article is protected by copyright. All rights ...
Rana A A Cardiovascular Division, Department of Pharmacology, I.S.F College of Pharmacy, Moga-142001, Punjab, - - 2014
Myocardial infarction is a pathological state which occurs due to severe abrogation of the blood supply (ischemia) to a part of heart, which can cause myocardial damage. The short intermittent cycles of sub-lethal ischemia and reperfusion has shown to improve the tolerance of the myocardium against subsequent prolonged ischemia/reperfusion (I/R)-induced ...
Agrawal Yogeeta Y Department of Pharmaceutical Sciences,Jaipur National University, Jagatpura, Jaipur-302017, India; Department of Pharmacology, All India Institute of Medical Sciences, New Delhi-110029, India; Department of Pharmacology, R.C.Patel Institute of Pharmaceutical Education and Research, Shirpur-425405, Maharashtra, - - 2014
Hesperidin has been shown to possess cardioprotective and anti-diabetic potential. Hitherto, its molecular mechanism on isoproterenol (ISO)-induced myocardial dysfunction in diabetes is still not explored. Hence, for the first time we sought to investigate whether hesperidin exerts any beneficial effect on the pathophysiology of myocardial infarction (MI) in diabetes through ...
Cudnoch-Jedrzejewska A A Department of Experimental and Clinical Physiology, Medical University of Warsaw, Pawinskiego str 3c, 02-106 Warsaw, Poland. Electronic address: - - 2014
Chronic mild stress (CMS) and myocardial infarction (MI) induce anhedonia, which is one of the symptoms of depression. The purpose of this study was to determine the role of the central V1 vasopressin receptors (V1R) in post-CMS and post-MI anhedonia. To this end, we investigated the effect of blockage the ...
Bonatti Rodolfo R Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil; Beth Israel Deaconess Medical Center, Boston, - - 2014
Ischemic heart disease is associated with dual risk for atrial and ventricular arrhythmias. We examined whether selectively targeting late INa with GS-458967 can reduce cardiac electrical instability and compared its effects to a clinically relevant dose of flecainide. Electrode catheters were positioned on left atrial appendage and left ventricle of ...
Song Rui R Department of Prevention, Tongji University School of Medicine, Shanghai, - - 2014
Myocardial hypertrophy that often leads to eventual heart failure is a leading cause of mortality worldwide. While both apoptosis and cell proliferation have been reported to play an important part in heart failure, its exact triggering mechanism is still unclear. Reports have shown that low concentrations of H2O2 (10-30 µM) can ...
Luedde Mark M Internal Medicine III: Cardiology and Angiology, University of Kiel, - - 2014
Programmed necrosis (necroptosis) represents a newly identified mechanism of cell death combining features of both apoptosis and necrosis. Like apoptosis, necroptosis is tightly regulated by distinct signalling pathways. A key regulatory role in programmed necrosis has been attributed to interactions of the receptor interacting kinases RIP1 and RIP3. However, the ...
Eijsvogels Thijs M H TM Henry Low Heart Center, Department of Cardiology, Hartford Hospital, Hartford, Connecticut; Department of Physiology, Radboud University Medical Center, Nijmegen, The - - 2014
Marathon running commonly causes a transient elevation of creatine kinase and cardiac troponin I (cTnI). The use of statins before marathon running exacerbates the release of creatine kinase from skeletal muscle, but the effect of statin use on exercise-induced cTnI release is unknown. We therefore measured cTnI concentrations in statin-using ...
Birnbaum Yochai Y The Section of Cardiology, Baylor College of Medicine, Houston, TX, USA; Texas Heart Institute, Baylor St. Luke's Medical Center, Houston, TX, USA. Electronic address: - - 2014
Left ventricular hypertrophy (LVH) induces changes in the depolarization and repolarization of the heart that alter the resting electrocardiogram (ECG). These changes include widening of the QRS duration, an increase in the QRS amplitude and secondary changes in the ST segment and T waves. Typically, there is ST segment depression ...
Raj Shashi S Department of Pediatrics, Division of Pediatric Cardiology, University of Miami Miller School of Medicine, Miami, FL, - - 2014
Anthracyclines have been widely used in children and adults to treat hematologic malignancies, soft-tissue sarcomas, and solid tumors. However, anthracyclines come with both short- and long-term cardiotoxic effects, ranging from occult changes in myocardial structure and function to severe cardiomyopathy and heart failure that may result in cardiac transplantation or ...
- - 2014
Corticosteroids have been shown to reduce short-term mortality during septic shock and therefore recommended in the most severe patients as adjuvant therapy. Until recently, recombinant human activated protein C (APC) was also considered in the management of more severe cases. As myocardial depression has long been recognized as a manifestation ...
Zhang Guoru G Department of Cardiovascular Disease, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050005, - - 2014
It is desirable to minimize the risk of adverse radiation effects associated with percutaneous coronary intervention. The aim of this study was to determine the impact of prolonging the interval between coronary angiography and percutaneous coronary intervention on X-ray-induced DNA double-strand breaks in blood lymphocytes using γ-H2AX immunofluorescence microscopy. Blood ...
Lujan Heidi L HL Department of Physiology, Wayne State University School of Medicine, Detroit, 48201, - - 2014
Reperfusion-induced lethal ventricular arrhythmias are observed during relief of coronary artery spasm, with unstable angina, exercise-induced ischemia, and silent ischemia. Accordingly, significant efforts are underway to understand the mechanisms responsible for reperfusion-induced lethal arrhythmias and mice have become increasingly important in these efforts. However, although reperfusion-induced sustained ventricular tachycardia leading ...
Xiao Cang-Song CS Department of Cardiovascular Surgery, Institute of Cardiac Surgery, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing 100853, - - 2014
To establish a cost-effective and reproducible procedure for induction of chronic left ventricular aneurysm (LVA) in rabbits. Acute myocardial infarction (AMI) was induced in 35 rabbits via concomitant ligation of the left anterior descending (LAD) coronary artery and the circumflex (Cx) branch at the middle portion. Development of AMI was ...
Ghanbari Hamid H Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, - - 2014
-Although ventricular tachycardia (VT) ablation is a widely used therapy for patients with VT, the ideal endpoints for this procedure are not well defined. We performed a meta-analysis of the published literature to assess the predictive value of non-inducibility of post-infarction VT for long-term outcomes after VT ablation. -We performed ...
Zholobenko A A Department of Medical Chemistry and Biochemistry, School of Medicine and Dentistry, Palacky University, HnÄ›votínská 3, Olomouc, 77515, Czech - - 2014
Silymarin, a standardised extract of Silybum marianum (milk thistle), comprises mainly of silybin, with dehydrosilybin (DHSB), quercetin, taxifolin, silychristin and a number of other compounds which are known to possess a range of salutary effects. Indeed, there is evidence for their role in reducing tumour growth, preventing liver toxicity, and ...
Gautier Sophie - - 2014
Granulocyte colony-stimulating factor (G-CSF) is a pharmacologic agent inducing neutrophil mobilization and a new candidate for neuroprotection and neuroregeneration in stroke. Its effects when used in combination with tissue plasminogen activator (tPA) were explored during the acute phase of ischemic stroke. We used a middle cerebral artery occlusion (MCAO) model ...
Sahu Bidya Dhar BD Medicinal Chemistry and Pharmacology Division, CSIR-Indian Institute of Chemical Technology (IICT), Hyderabad, 500 007, - - 2014
Myocardial oxidative stress leading to apoptosis and remodeling is the major consequence of ischemic heart disease. In the present study, we investigated the effect of Lagerstroemia speciosa L. leave (LS) extract containing 1 % corosolic acid in the context of cardiovascular disorder by using isoproterenol (ISO)-induced myocardial injury mouse model. Serum ...
Varga Zoltán V ZV Semmelweis - - 2014
We aimed to characterize early changes in microRNA expression in acute cardioprotection by ischemic pre- and postconditioning in rat hearts. Hearts isolated from male Wistar rats were subjected to i) time-matched non-ischemic perfusion, ii) ischemia/reperfusion (30 min coronary occlusion and 120 min reperfusion), iii) preconditioning (3x5 min coronary occlusion) followed ...
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