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Tippetts Trevor S - - 2014
Cigarette smoking is a common and lethal worldwide habit, with considerable mortality stemming from its deleterious effects on heart function. While current theories posit altered blood lipids and fibrinogen metabolism as likely mediators, none have explored the role of the sphingolipid ceramide in exacerbating heart function with smoke exposure. Ceramide ...
Verschure Derk O DO aDepartment of Nuclear Medicine, Academic Medical Center, University of Amsterdam bCardiology Centers of the Netherlands, Amsterdam cDepartment of Cardiology, Medical Center Alkmaar, Alkmaar dDepartment of Nuclear Medicine, Diakonessenhuis, Utrecht, The Netherlands eDepartment of Nuclear Medicine f3rd Department of Medicine, Cardiology and Emergency Medicine, Wilhelminenspital, Vienna, - - 2014
The I-metaiodobenzylguanidine (I-MIBG) late heart-to-mediastinum ratio (H/M) is a well-established prognostic parameter in patients with chronic heart failure (CHF). However, I presents imaging problems owing to high-energy photon emission leading to penetration of collimator septa and subsequent reduction in image quality. Most likely this affects the H/M ratio and may ...
Huang Yu-Sen YS Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei 100, Taiwan. ; Department of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 100, Taiwan. ; Department of Medical Imaging, National Taiwan University Hospital Yun Lin Branch, Yun-Lin 640, - - 2014
This study strived to evaluate the relationship between degree of pulmonary emphysema and cardiac ventricular function in chronic obstructive pulmonary disease (COPD) patients with pulmonary hypertension (PH) using electrocardiographic-gated multidetector computed tomography (CT). Lung transplantation candidates with the diagnosis of COPD and PH were chosen for the study population, and ...
Leary Peter J PJ University of Washington, Medicine , Seattle, Washington, United States ; - - 2014
Rationale: H2RA use is common and may act directly on the heart through myocardial H2 receptors or indirectly through changes in pulmonary vascular resistance. Objective: To determine the relationship between histamine H2 receptor antagonist (H2RA) use and right ventricular (RV) morphology. Methods: We studied 4,124 participants in the Multi-Ethnic Study ...
Kim Min-Seok MS Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul National University College of - - 2014
A 76-year-old male underwent a left upper lobectomy with wedge resection of the superior segment of the left lower lobe using video-assisted thoracoscopic surgery (VATS) for non-small-cell lung cancer of the left upper lobe. He presented with shortness of breath, fever, and leukocytosis. Chest radiography showed atelectasis at the remaining ...
Ricci Fabrizio F Institute of Cardiology, 'G. d'Annunzio' University, - - 2014
Lung ultrasonography is an emerging, user-friendly and easy-to-use technique that can be performed quickly at the patient's bedside to evaluate several pathologic conditions affecting the lung. Ultrasound lung comets (ULCs) are an echographic sign of uncertain biophysical characterisation mostly attributed to water-thickened subpleural interlobular septa, but invariably associated with increased ...
Wang Lei L Department of Nuclear Medicine, Cardiovascular Institute & Fu Wai Hospital, Peking Union Medical College & Chinese Academy of Medical Science, Beijing, - - 2014
When pathologically externalized, phosphatidylethanolamine (PE) is a potential surrogate marker for detecting tissue injuries. (99m)Tc-labeled duramycin is a peptide-based imaging agent that binds PE with high affinity and specificity. The goal of the current study was to investigate the clearance kinetics of (99m)Tc-labeled duramycin in a large animal model (normal ...
Cour Martin M Universite de - - 2014
Opening of the mitochondrial permeability transition pore (mPTP) appears to be a pivotal event in myocardial ischemia-reperfusion (I/R) injury. Resuscitated cardiac arrest (CA) leads to the post-CA syndrome that encompasses, not only myocardial dysfunction, but also brain injury, failure of other organs (kidney, liver or lung), and systemic response to ...
Dixon Dani-Louise DL Intensive and Critical Care Unit, Adelaide, Australia 5001; Department of Critical Care Medicine, Adelaide, Australia 5001. Electronic address: - - 2014
Chronic heart failure (CHF) following coronary artery ligation and myocardial infarction in the rat leads to a homeostatic reduction in surface tension with associated alveolar type II cell hyperplasia and increased surfactant content, which functionally compensates for pulmonary collagen deposition and increased tissue stiffness. To differentiate the effects on lung ...
Johtatsu Takanobu T Department of Respiratory Medicine, School of Medicine, University of Occupational and Environmental Health, - - 2014
A 73-year-old Japanese man visited a local hospital due to palpitations and dyspnea. He was diagnosed as having lung cancer (adenocarcinoma, cT1aN2M1b (BRA), stage Ⅳ), but he did not want to receive any anticancer medications, and was simply being observed. Several months later, he was referred to our hospital due ...
Neilan Tomas G TG Division of Cardiology, Department of Medicine, Massachusetts General Hospital; Cardiac MR PET CT Program, Division of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, - - 2014
We aimed to assess whether chronic obstructive pulmonary disease (COPD) is associated with expansion of the myocardial extracellular volume (ECV) using T1 measurements. Adult COPD patients Global Initiative for Chronic Obstructive Lung Disease [GOLD] stage 2 or higher and free of known cardiovascular disease were recruited. All study patients underwent ...
Buchholz Bruno B Institute of Cardiovascular Physiopathology, Department of Pathology, Faculty of Medicine, University of Buenos Aires and Institute of Biochemistry and Molecular Medicine (IBIMOL), J. E. Uriburu 950 - 2nd floor. C1114AAD, Buenos Aires, - - 2014
In a previous research, we described that vagal stimulation increases the infarct size by sympathetic co-activation. The aim of this study was to determine if hemodynamic changes secondary to the vagal stimulation are able to activate sympathetic compensatory neural reflexes, responsible for increasing the infarct size. A second goal was ...
Sulkin Matthew S MS - - 2014
Instability of the inner mitochondrial membrane potential (ΔΨm) has been implicated in electrical dysfunction, including arrhythmogenesis during ischemia/reperfusion. Monitoring ΔΨm has led to conflicting results, where depolarization has been reported as sporadic and as a propagating wave. This study was designed to resolve the aforementioned differences and determine the unknown ...
Silvetti Massimo Stefano MS Arrhythmia Unit and Syncope Unit, Department of Paediatric Cardiology, Bambino Gesù Children's Hospital, IRCCS, Via Torre di Palidoro 1, 00050 Palidoro-Rome, Italy - - 2014
Right ventricular (RV) pacing may induce left ventricular (LV) dysfunction: neonates and infants with isolated congenital complete/advanced atrioventricular block (CCAVB) are at high risk of developing RV pacing-induced LV dyssynchrony, remodelling, and dysfunction. We prospectively investigated whether LV pacing results in normal LV function and good clinical status in the ...
Thakkar Jay B JB Westmead Hospital & Sydney Medical School, University of Sydney, Sydney, - - 2014
-Inducible Ventricular tachycardia (VT) is a strong predictor of spontaneous ventricular tachyarrhythmia following ST elevation myocardial infarction (STEMI). Reduced left ventricular ejection fraction (LVEF) predisposes patients to inducible ventricular tachycardia post STEMI. However the role of right ventricular (RV) dysfunction in predisposing to inducible VT has not been described previously. ...
Guill Antonio A ITACA, Universitat Politècnica de València, Valencia, España. Electronic address: - - 2014
Abnormal QT interval durations and dispersions have been associated with increased risk of ventricular arrhythmias. The present study examines the possible arrhythmogenic effect of inducing QT interval variations through local epicardial cooling and warming. In 10 isolated rabbit hearts, the temperatures of epicardial regions of the left ventricle were modified ...
Saeed Diyar D Clinic for Cardiovascular Surgery, Heinrich-Heine University of Düsseldorf, Düsseldorf, Germany. Electronic address: - - 2014
Suction events are among the frequently encountered issues after the implantation of a left ventricular assist device and may induce malignant arrhythmias. Several factors may play a role in inducing these suction events. A proper inflow cannula insertion site at the time of surgery, particularly in hypertrophic left ventricles, plays ...
Lee Teresa E TE Duke - - 2014
Activated/uninhibited calcineurin is both necessary and sufficient to induce cardiac hypertrophy, a condition that often leads to dilated cardiomyopathy, heart failure, and sudden cardiac death. We expressed constitutively active calcineurin in the adult heart of Drosophila melanogaster and identified enlarged cardiac chamber dimensions and reduced cardiac contractility. In addition, expressing ...
Itou Junji J Department of Genetics, Cell Biology & Development, University of Minnesota; Department of Stem cell institute, University of - - 2014
Background: The zebrafish heart regenerates after various severe injuries. Common processes of heart regeneration are cardiomyocyte proliferation, activation of epicardial tissue and neovascularization. In order to further characterize heart regeneration processes, we introduced milder injuries and compared responses to those induced by ventricular apex resection, a widely used injury method. ...
Frommeyer Gerrit G Division of Electrophysiology, Department of Cardiovascular Medicine, University of Münster, Münster, Germany. Electronic address: - - 2014
The present ESC guidelines on atrial fibrillation have introduced vernakalant (VER) for pharmacological cardioversion of atrial fibrillation. Therefore, the aim of the present study was to investigate possible proarrhythmic effects of vernakalant in an experimental model of heart failure (HF). In twelve female rabbits, HF was induced by 4 weeks ...
Packard René R S RR Department of Medicine (Cardiology), University of California, Los Angeles, California; - - 2014
Absolute quantitation of myocardial blood flow (MBF) by PET is an established method of analyzing coronary artery disease (CAD) but subject to the various shortcomings of available radiotracers. Flurpiridaz F 18 is a novel PET radiotracer that exhibits properties of an ideal tracer. A new absolute perfusion quantitation method with ...
Huang Bing B Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, - - 2014
Renal sympathetic nerve (RSN) activity plays a key role in systemic sympathetic hyperactivity. Previous studies have shown that cardiac sympathetic hyperactivity, especially the left stellate ganglion (LSG), contributes to the pathogenesis of ventricular arrhythmias (VAs) after acute myocardial infarction (AMI). Twenty-eight dogs received 3h of continuous left-sided electrical stimulation of ...
Wang Zhiqiang Z Department of Thoracic and Cardiovascular Surgery, Affiliated Hospital of Jiangnan University, The Fourth People's Hospital of Wuxi City, Wuxi, People's Republic of - - 2014
Video-assisted thoracic surgery (VATS) has been widely applied in the treatment of lung cancer. However, few studies have focused on the clinical factors predicting the major postoperative complications. Clinical data from 525 patients who underwent resection of primary lung cancer with VATS from January 2007-August 2011 were retrospectively analyzed. Risk ...
Siu Kin Lung KL Divisions of Molecular Medicine and Cardiology, Department of Anesthesiology, Cardiovascular Research Laboratories, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA; Divisions of Molecular Medicine and Cardiology, Department of Medicine, Cardiovascular Research Laboratories, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, - - 2014
Despite an established role of mitochondrial dysfunction in cardiac ischemia reperfusion (I/R) injury, the upstream activators have remained incompletely defined. We have recently identified an innovative role of exogenously applied netrin-1 in cardioprotection, which is mediated by increased nitric oxide (NO) bioavailability. Here, we tested the hypothesis that this "pharmacological" ...
Kesdangsakonwut S S Laboratory of Comparative Pathology, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, - - 2014
Cardiomyopathies have been rarely described in rabbits. Here we report myocardial necrosis of the ventricular wall in rabbits with experimentally induced rabies. Myocardial lesions were found only in rabbits with brain lesions, and the severity of the cardiac lesions was proportional to that of the brain lesions. Neither the frequency ...
Arrebola-Moreno Antonio Luis AL Unidad de Hemodinámica, Servicio de Cardiología, Hospital Universitario Virgen de las Nieves, Granada, Spain; Cardiovascular and Cell Sciences Research Institute, St. George's, University of London, London, - - 2014
Impaired coronary microvascular dilatory function can lead to exercise induced myocardial ischemia and angina pectoris even in patients without significant (>50%) obstructive coronary atherosclerosis (APWOCA). Diffuse distal vessel epicardial spasm and microvascular spasm have been also proposed as a plausible explanation for angina at rest in these patients. However, objective ...
Cinca Juan J Department of Cardiology, Hospital de la Santa Creu i Sant Pau, Institute of Biomedical Research IIB Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain. Electronic address: - - 2014
Acute myocardial ischemia in opposite regions may attenuate the ST-segment changes but whether this effect is expressed differently in extracardiac compared to direct intramyocardial recordings, is not well known. To characterize ST-segment changes induced by opposite ischemic regions in intact and isolated perfused pig hearts. Left anterior descending (LAD) and ...
Gao Yan Y Department of Pharmacology, Shanghai University of Traditional Chinese Medicine, NO. 1200 Cailun Road, Shanghai, 201203, - - 2014
To examine the effects of houttuynin on ventricular remodeling induced by coronary artery ligation in rats and the underlying mechanisms. A rat model of ventricular remodeling was established by left coronary artery ligation (CAL). Rats were randomly divided into four groups: CAL control, CAL plus 40mg/kg captopril, CAL plus 100mg/kg ...
Atalay Figen - - 2014
Cardiac toxicity is one of the life-threatening complications of cancer therapy. Systemic anticancer treatments may exert their own toxic effects or can aggravate adverse effects of other drugs. We report a case of cyclophosphamide-induced cardiotoxicity in a patient with normal cardiac functions before chemotherapy. A 66-year-old Caucasian woman with a ...
Santoro Francesco F Cardiology Department, University of Foggia, Foggia, - - 2014
We report coronary angio findings of very late (10-year) coronary spasm inducing acute myocardial infarction with typical chest pain in a heart transplant recipient. Coronary spasm was promptly relieved by intra-coronary infusion of nitrates.
Der Sarkissian S S Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM); Faculty of Medicine, Department of Surgery, Université de - - 2014
Celastrol, a natural triterpene from plant extracts, has been used in traditional oriental medicine to treat various diseases. In this study we investigate the cardioprotective effects of Celastrol against ischemia. Protective pathways induced by Celastrol were investigated in H9c2 rat cardiomyoblast hypoxic cultures and in a rat model of myocardial ...
Benoist David D Multidisciplinary Cardiovascular Research Centre, University of Leeds, UK; L'Institut de Rythmologie et Modelisation Cardiaque, INSERM U1045, Université de Bordeaux, - - 2014
We demonstrate the synergistic benefits of using multiple technologies to investigate complex multi-scale biological responses. The combination of reductionist and integrative methodologies can reveal novel insights into mechanisms of action by tracking changes of in vivo phenomena to alterations in protein activity (or vice versa). We have applied this approach to ...
Li Yan Y Division of Histology & Embryology, Key Laboratory for Regenerative Medicine of the Ministry of Education, Medical College, Jinan University, Guangzhou 510632, - - 2014
The developing embryo is very sensitive to oxidative stress and excess reactive oxygen species (ROS) generation is often associated with cardiovascular malformation. However, little is known about the adverse effects of ROS during heart morphogenesis, especially during the formation of the atria and ventricles. We have treated early chick embryos ...
Fang Fang F Division of Cardiology, Department of Medicine and Therapeutics, Institute of Vascular Medicine; Institute of Innovative Medicine; HEART Center; and Li Ka Shing Institute of Health Sciences, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong; Beijing AnZhen Hospital, Capital Medical University, - - 2014
Right ventricular (RV) pacing may affect myocardial perfusion and coronary blood flow; however, it remains unknown whether this is related to systolic dyssynchrony induced by RV pacing. This prospective study was aimed to assess the relationship between dyssynchrony and the changes of coronary blood flow. Seventy patients with sinus node ...
Zhou Zhi-Wen ZW Department of Cardiology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, P.R. - - 2014
The purpose of this study was to explore the feasibility of continuous remote monitoring, and the induction and termination of malignant ventricular arrhythmias (VAs) by a novel implantable electronic cardiovascular device (IECD) system in rabbits with myocardial infarction (MI). The IECD was implanted and MI was induced by ligation of ...
Pothiawala S E SE Department of Emergency Medicine, Singapore General Hospital, - - 2014
Hyperkalemia is an acute life-threatening disorder presenting to the emergency department. Patients with hyperkalemia may manifest characteristic electrocardiographic changes including tented T waves, widening of the QRS complex and loss of P waves, sine wave pattern and eventually asystole. There have been only few reports of hyperkalemia causing ST segment ...
Chakraborty Manodeep M Department of Pharmacology, Bhagwant University, Ajmer, Rajasthan, - - 2014
Globally, the rate of development of myocardial diseases and hypertension is very common, which is responsible for incremental morbidity and mortality statistics. Treatment of ischemic hypertensive patients with diuretics such as hydrochlorothiazide (HCTZ) can precipitate myocardial infarction due to hypokalemia. This study was undertaken to evaluate the pharmacodynamic interaction of ...
Zhou Su-Feng SF Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, 430022, - - 2014
Inflammatory responses play an important role in the pathogenesis of adverse ventricular remodeling after myocardial infarction (MI). We previously demonstrated that interleukin (IL)-17A plays a pathogenic role in myocardial ischemia/reperfusion injury and viral myocarditis. However, the role of IL-17A in post-MI remodeling and the related mechanisms have not been fully ...
Wang Jiangyou J Department of Cardiology, the First Affiliated Hospital of Guangxi Medical University, Nanning, - - 2014
Background/Aims: Growing evidence shows that phosphatase and tensin homolog deleted on chromosome ten (PTEN) is involved in regulating inflammation in different pathological conditions. Therefore, we hypothesized that the upregulation of PTEN correlates with the impairment of cardiac function in swine following coronary microembolization (CME). Methods: To possibly disclose an anti-inflammatory ...
Hofmann Ulrich U University of Wuerzburg, University Clinic, Comprehensive Heart Failure Center, Department of Internal Medicine I, Würzburg, Germany - - 2014
-Activation of innate immunity, especially infiltration of monocytes, is critical for proper wound healing and scar formation after myocardial infarction (MI). Therefore, we tested the hypothesis that interleukin-13 (IL-13), which influences the differentiation of monocytes/ macrophages and has pro-fibrotic properties, modulates wound healing and remodelling after myocardial infarction. -MI was ...
Y-Hassan Shams S Karolinska Institute at Karolinska University Hospital, Department of Cardiology , Stockholm , - - 2014
Background and objectives: Myocardial depression in the setting of sepsis and septic shock is common and has been recognized for a long time. The aim of this study is to find out an association and causal link between sepsis and takotsubo syndrome (TS). Methods: Fifteen cases of TS were studied. ...
Khan Muhammad F - - 2014
Newly developed antineoplastic drugs have resulted in improvements in morbidity and mortality from many forms of cancers. However, some of these new chemotherapeutic agents have potentially lethal side effects, which are now being exposed with their widespread use. Gemcitabine is a nucleoside analog, which is a commonly used agent for ...
Riede Florian F Electrophysiology/Cardiology, University of Basel Hospital, Basel, - - 2014
An 18-year-old male with a history of symptomatic tachycardia was referred for ablation. The ECG (Panel A) showed preexcitation suggestive of a posteroseptal accessory pathway. Orthodromic AV-reentry tachycardia (ORT) with a wide right bundle branch block (RBBB) pattern was inducible (Panel B). This article is protected by copyright. All rights ...
Rana A A Cardiovascular Division, Department of Pharmacology, I.S.F College of Pharmacy, Moga-142001, Punjab, - - 2014
Myocardial infarction is a pathological state which occurs due to severe abrogation of the blood supply (ischemia) to a part of heart, which can cause myocardial damage. The short intermittent cycles of sub-lethal ischemia and reperfusion has shown to improve the tolerance of the myocardium against subsequent prolonged ischemia/reperfusion (I/R)-induced ...
Agrawal Yogeeta Y Department of Pharmaceutical Sciences,Jaipur National University, Jagatpura, Jaipur-302017, India; Department of Pharmacology, All India Institute of Medical Sciences, New Delhi-110029, India; Department of Pharmacology, R.C.Patel Institute of Pharmaceutical Education and Research, Shirpur-425405, Maharashtra, - - 2014
Hesperidin has been shown to possess cardioprotective and anti-diabetic potential. Hitherto, its molecular mechanism on isoproterenol (ISO)-induced myocardial dysfunction in diabetes is still not explored. Hence, for the first time we sought to investigate whether hesperidin exerts any beneficial effect on the pathophysiology of myocardial infarction (MI) in diabetes through ...
Cudnoch-Jedrzejewska A A Department of Experimental and Clinical Physiology, Medical University of Warsaw, Pawinskiego str 3c, 02-106 Warsaw, Poland. Electronic address: - - 2014
Chronic mild stress (CMS) and myocardial infarction (MI) induce anhedonia, which is one of the symptoms of depression. The purpose of this study was to determine the role of the central V1 vasopressin receptors (V1R) in post-CMS and post-MI anhedonia. To this end, we investigated the effect of blockage the ...
Bonatti Rodolfo R Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil; Beth Israel Deaconess Medical Center, Boston, - - 2014
Ischemic heart disease is associated with dual risk for atrial and ventricular arrhythmias. We examined whether selectively targeting late INa with GS-458967 can reduce cardiac electrical instability and compared its effects to a clinically relevant dose of flecainide. Electrode catheters were positioned on left atrial appendage and left ventricle of ...
Song Rui R Department of Prevention, Tongji University School of Medicine, Shanghai, - - 2014
Myocardial hypertrophy that often leads to eventual heart failure is a leading cause of mortality worldwide. While both apoptosis and cell proliferation have been reported to play an important part in heart failure, its exact triggering mechanism is still unclear. Reports have shown that low concentrations of H2O2 (10-30 µM) can ...
Luedde Mark M Internal Medicine III: Cardiology and Angiology, University of Kiel, - - 2014
Programmed necrosis (necroptosis) represents a newly identified mechanism of cell death combining features of both apoptosis and necrosis. Like apoptosis, necroptosis is tightly regulated by distinct signalling pathways. A key regulatory role in programmed necrosis has been attributed to interactions of the receptor interacting kinases RIP1 and RIP3. However, the ...
Eijsvogels Thijs M H TM Henry Low Heart Center, Department of Cardiology, Hartford Hospital, Hartford, Connecticut; Department of Physiology, Radboud University Medical Center, Nijmegen, The - - 2014
Marathon running commonly causes a transient elevation of creatine kinase and cardiac troponin I (cTnI). The use of statins before marathon running exacerbates the release of creatine kinase from skeletal muscle, but the effect of statin use on exercise-induced cTnI release is unknown. We therefore measured cTnI concentrations in statin-using ...
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