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Chou Chung-Chuan - - 2013
Dantrolene prevents arrhythmogenic Ca(2+) release during heart failure (HF). However, direct evidence to support its antiarrhythmic effects in failing hearts with acute myocardial infarction (AMI) is lacking. HF was induced by right ventricular pacing (312 bpm, 4 weeks) in 19 rabbits. AMI was induced by coronary artery ligation in rabbits ...
Yalin Kivanc - - 2013
The extent of peri-infarct zone (PIZ) by contrast-enhanced cardiac magnetic resonance (ce-CMR) has been related to inducibility of ventricular arrhythmia in patients with ischemic cardiomyopathy. However, this relationship has not been established in postmyocardial infarction (post-MI) patients with relatively reserved left ventricular (LV) systolic function yet. In this study, we ...
Casals Gregori - - 2013
Background: The molecular mechanisms by which myocardial ischemia translates into ventricular remodeling remain unclear. Methods: We investigated whether hypoxia and proinflammatory cytokines are specific inducers of remodeling signals in an in vitro model of cultured adult human ventricular myocytes (AC16 cells). Results: Hypoxia modified the ratio of matrix remodeling factors ...
Nordin Charles - - 2013
Hypoglycemia increases the risk for both overall and sudden death. At a cellular level, hypoglycemia causes alterations in the physiology of myocardial tissue that are identical to proarrhythmic medications. Reduced serum glucose blocks the repolarizing K(+) channel HERG, which leads to action potential and QT prolongation and is uniformly associated ...
Chrastina Adrian - - 2013
We describe a novel model of myocardial infarction (MI) in rats induced by percutaneous transthoracic low-energy laser-targeted photodynamic irradiation. The procedure does not require thoracotomy and represents a minimally invasive alternative to existing surgical models. Target cardiac area to be photodynamically-irradiated was triangualted from the thoracic X-ray scans. The acute ...
Dinov Borislav - - 2013
Data on the outcomes of ventricular tachycardia (VT) ablation in non-ischemic dilated cardiomyopathy (NIDCM) are insufficient. The HEART CENTRE OF LEIPZIG VT (HELP-VT) STUDY WAS PROSPECTIVELY CONDUCTED TO COMPARE OUTCOMES AFTER RADIOFREQUENCY CATHETER ABLATION (RFCA) OF VT IN PATIENTS WITH NIDCM AS COMPARED TO ISCHEMIC CARDIOMYOPATHY (ICM). Two hundred and ...
Li Yu-Juan - - 2013
Salvia miltiorrhiza (SM, also known as DanShen) is one of the well-known widely-used Chinese herbal medicines in clinical, containing phenolic compounds and potent antioxidant properties. Salvianolic acid A (SAA)is the most potent component of SM. A modern experimental strategy for treating myocardial ischemia is to induce neovascularization of the heart ...
Armaganijan Luciana - - 2013
Abnormal ventricular repolarization has been proposed as a marker of arrhythmogenesis, and cardiovascular morbidity and mortality. However, little is known about the influence of the interval between the peak and the end of the T wave (Tp-Te) on the inducibility of sustained ventricular arrhythmias (VA) in patients with Chagas disease ...
Bohora Shomu S U.N.Mehta Institute of Cardiology and Research Centre, - - 2013
A 13 year old boy having idiopathic ventricular tachycardia had non-inducible tachycardia twice on electrophysiology (EP) study due to suppression of arrhythmia by local anaesthetic agent, lignocaine. This case report demonstrates a cause of non-inducibility or arrhythmia during EP study and effect of lignocaine in suppression of idiopathic ventricular tachycardia.
Carballeira Pol Lidia - - 2013
Frequent ventricular premature depolarizations (VPDs) can cause cardiomyopathy (CMP). The mechanisms underlying its development remain unclear with VPD burden only a weak predictor of risk. Among individuals with normal left ventricular ejection fraction (LVEF), we sought to determine whether VPD QRS duration at time of initial presentation could predict risk ...
Ramadan Ronnie - - 2013
ObjectiveMental stress provokes myocardial ischemia in many patients with stable coronary artery disease (CAD). Mental stress-induced myocardial ischemia (MSIMI) portends a worse prognosis, independent of standard cardiac risk factors or outcome of traditional physical stress testing. Angiotensin II plays a significant role in the physiological response to stress, but its ...
Akutsu Yasushi - - 2013
A 72-year-old female was diagnosed as a stress-induced cardiomyopathy from apical ballooning pattern of left ventricular dysfunction without coronary artery stenosis after the mental stress. ECG showed the transient T-wave inversions after the ST-segment elevations. By the mental stress after 1 year, she showed a transient dysfunction with similar ECG ...
Meserve Emily E - - 2013
Abstract We present a clinicopathologic study of the youngest reported child with lethal cyclophosphamide-induced cardiotoxicity following hematopoietic stem cell transplantation for β-thalassemia major and the first to report the use of extracorporeal membrane oxygenation (ECMO) as a therapeutic modality to bridge the patient to myocardial recovery. Despite improvement of myocardial ...
Hsieh Calvin H C - - 2013
-Ventricular tachycardia (VT) is a significant complication of myocardial infarction. Radiofrequency ablation (RFA) for post-infarct VT is reserved for drug refractory VT or VT storms. Our hypothesis is that RFA in the early post-infarct period could abolish or diminish late recurrences of VT. -Myocardial infarct was induced by balloon occlusion ...
Augustine Daniel D From the Oxford Cardiovascular Clinical Research Facility, University of Oxford, Oxford, United Kingdom (D.A., E.L., L.N., A.J.L., E.F.D., P.L.); and Department of Clinical Immunology, Oxford University Hospitals NHS Trust, Oxford, United Kingdom (L.V.A., - - 2014
Microparticles are cell-derived membrane vesicles, relevant to a range of biological responses and known to be elevated in cardiovascular disease. To investigate microparticle release during cardiac stress and how this response differs in those with vascular disease. We measured a comprehensive panel of circulating cell-derived microparticles by a standardized flow ...
Lu Chen - - 2013
Innate immune and inflammatory responses mediated by Toll like receptors (TLRs) have been implicated in myocardial ischemia/reperfusion (I/R) injury. This study examined the role of TLR3 in myocardial injury induced by two models, namely, myocardial infarction (MI) and I/R. First, we examined the role of TLR3 in MI. TLR3 deficient ...
Kolettis Theofilos M - - 2013
Abstract Background: The relative role of acute myocardial ischemia and infarction in ventricular arrhythmogenesis is incompletely understood. We compared the arrhythmia pattern after ischemia/infarction to that observed after direct myocardial necrosis without preceding ischemia in rats. Methods: Coagulation necrosis was induced in Wistar rats (n=20, 280±3 g) by radiofrequency current ...
Costa José F - - 2013
Short periods of myocardial ischemia followed by reperfusion induce a cardioprotective mechanism when the myocardium is subsequently subjected to a prolonged period of ischemia, a phenomenon known as ischemic preconditioning. As well as its application in the myocardium, ischemic preconditioning can also be induced by brief interruptions of blood flow ...
Cai Zheqing Z Departments of Medicine, Biological Chemistry, Pediatrics, Oncology, and Radiation Oncology, Institute for Cell Engineering, and McKusick-Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD - - 2013
Both preclinical and clinical studies suggest that brief cycles of ischemia and reperfusion in the arm or leg may protect the heart against injury following prolonged coronary artery occlusion and reperfusion, a phenomenon known as remote ischemic preconditioning. Recent studies in mice indicate that increased plasma interleukin-10 (IL-10) levels play ...
Wang Wen-Long - - 2013
Abnormal enhanced transmural dispersion of repolarization (TDR) plays an important role in the maintaining of the severe ventricular arrhythmias such as torsades de pointes (TDP) which can be induced in long-QT (LQT) syndrome. Taking advantage of an in vitro rabbit model of LQT2, we detected the effects of KN-93, a ...
Lee Wonho W Department of Internal Medicine, Kangwon National University Hospital, Chuncheon, - - 2013
Amiodarone is a widely used antiarrhythmic agent. Among its various adverse effects, amiodarone-induced pulmonary toxicity (APT) is the most life threatening complication, which has been described mostly in patients who have been in treatment with high accumulative doses for a long duration of time. However, amiodarone therapy in short-term duration ...
Ramadan Ronnie R Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, - - 2013
Mental stress-induced myocardial ischemia (MSIMI) is associated with adverse prognosis in patients with coronary artery disease (CAD), yet the mechanisms underlying this phenomenon remain unclear. We hypothesized that compared with exercise/pharmacological stress-induced myocardial ischemia (PSIMI) that is secondary to the atherosclerotic burden of CAD, MSIMI is primarily due to vasomotor ...
Wu Xiaoqian - - 2013
The mechanisms underlying the myocardial protection of valsartan against ischemia/reperfusion (I/R) injury are complicated and remain unclear. The aim of this study was to investigate whether autophagy machinery was involved in the protection against I/R injury that is induced by valsartan. In vivo rat hearts were subjected to ischemia by 30 min ...
Zhao Yu-Juan - - 2013
To evaluate the effect of high thoracic epidural analgesia (HTEA) in congestive heart failure (CHF). Rat model of CHF. Harbin Medical University, Harbin, Heilongjiang, China. One hundred thirty-five rats. HTEA involved 5 times daily injections of 0.1% lidocaine at the T3-T4 level. The authors examined myocardial norepinephrine (NE), angiotensin II ...
Zhou Qina - - 2013
The epicardial fat pad (FP) integrates the autonomic innervation between the extrinsic and intrinsic cardiac autonomic nervous system and affects atrial electrophysiology and pathophysiology. Eighteen dogs were divided into two groups: sequential ablation of sinoatrial node FP (SAN-FP) and atrioventricular node FP (AVN-FP). Sinus rate (SR), atrial fibrillation (AF) inducibility, ...
Pouliopoulos Jim - - 2013
Collagen has been attributed as the principle structural substrate of ventricular tachycardia (VT) post-myocardial infarction (MI) even though adiposity of myocardium post-MI is well recognised histologically. We investigated the association of intramyocardial adiposity in comparison to collagen on electrophysiological (EP) properties, connexin-43 (Cx43) expression, and VT induction post-MI. Simultaneous, left ...
Hsieh Calvin H C - - 2013
-Sudden arrhythmic death post myocardial infarction (MI) is most frequent in the first month. Early programmed ventricular stimulation (PVS) (within 1 week) post-MI has been able to identify longterm ventricular tachycardia (VT) occurrence. We aimed to determine the timing of development and stabilization of VT circuits following MI, and how ...
Meng Jing - - 2013
Impaired ventricular repolarization can lead to long QT syndrome (LQT), a proarrhythmic disease with high risk of developing lethal ventricular tachyarrhythmias. The compound ICA-105574 is a recently developed hERG activator and it enhances IKr current with very high potency by removing the channel inactivation. The present study was designed to ...
Queenthy S Sharmila - - 2013
The aim of the present study was to evaluate the protective effects of diosmin on experimentally induced myocardial infarcted rats. Diosmin (5 and 10mg/kg body weight) was administered orally as pretreatment daily for a period of 10 days. Then isoproterenol (100mg/kg) was injected subcutaneously into rats at an interval of ...
Khorrami A - - 2013
Myocardial infarction (MI) was induced by subcutaneous injection of isoproterenol (ISO) to investigate the effect of ISO on Coenzyme Q10 (CoQ10) content of myocardium and subsequent effects on lipid peroxidation, electrocardiogram pattern and hemodynamic parameters of the rat's heart.36 male Wistar rats were divided randomly into 6 groups. To induce ...
Chemaly Elie R - - 2013
Pathological left ventricle (LV) hypertrophy (LVH) results in reactive and replacement fibrosis. Volume overload LVH (VOH) is less profibrotic than pressure overload LVH (POH). Studies attribute subendocardial fibrosis in POH to ischemia, and reduced fibrosis in VOH to collagen degradation favoring dilatation. However, the mechanical origin of the relative lack ...
Lumens Joost J Hôpital Cardiologique du Haut-Lévêque, CHU Bordeaux, L'Institut de rythmologie et modélisation cardiaque (LIRYC), Université Bordeaux, Bordeaux, France; Maastricht University Medical Center, Cardiovascular Research Institute Maastricht (CARIM), Maastricht, the Netherlands. Electronic address: - - 2013
The purpose of this study was to enhance understanding of the working mechanism of cardiac resynchronization therapy by comparing animal experimental, clinical, and computational data on the hemodynamic and electromechanical consequences of left ventricular pacing (LVP) and biventricular pacing (BiVP). It is unclear why LVP and BiVP have comparative positive ...
Swyers T - - 2013
The myocardium has an innate ability to protect itself from ischemic events. This protection occurs when the myocardium is exposed to a brief ischemic period prior to a more extreme ischemic event. This is termed ischemic preconditioning. Ischemic preconditioning induces a series of molecular pathways that protect the cardiac myocyte; ...
Schweiger Martin - - 2013
Evolution of ventricular assist devices (VADs) leading to miniaturization has made intracorporeal implantation in children feasible. Ventricular assist device therapy for anthracycline-induced cardiomyopathy (CMP) in adults has been reported. We report the case of an 8-year-old child (body surface area 0.97 m) presenting with anthracycline-induced CMP being successfully treated with ...
Cedraz Swellen Schuenemann - - 2013
Chagas disease has become a global problem due to changing migration patterns. An electrophysiological study is generally indicated for assessing sinus node function, conduction through the atrioventricular node and His-Purkinje system, in addition to evaluating the mechanisms of arrhythmia. The aim of this study was to describe the characteristics of ...
Liu Qingwei - - 2013
Toll-like receptor 4 (TLR4) is crucial in cardiomyocyte apoptosis induced by myocardial infarction (MI) and carvedilol has been reported to have anti-apoptotic effects. We hypothesized that the effects of this agent are in part mediated through TLR4 signaling pathways. A total of 48 rats were randomized to the following groups ...
Okuyan Hızır - - 2013
Itraconazole is a broad-spectrum antifungal agent. It rarely leads to adverse the cardiovascular effects, especially heart failure. We present here a case of a 60-year-old female patient with itraconazole induced heart failure.
Zaman Sarah - - 2013
-Electrophysiologic study (EPS) following myocardial infarction may have a role in identifying patients at risk of sudden cardiac death (SCD). It has been shown previously that inducible very fast ventricular tachycardia (VFVT) cycle length (CL) 200-230ms is predictive of arrhythmia recurrence; however, its significance early following reperfusion in ST-elevation myocardial ...
Ashruf Jesse F - - 2013
The ultimate goal of therapy for cardiogenic shock is to restore microcirculatory function and thereby restore the oxygen supply to sustain cellular function. Therapeutic measures mainly focus on improving pressure-derived macrocirculatory parameters. However, it is increasingly clear that to achieve significant progress in treatment, microcirculatory physiopathological mechanisms must be considered. ...
Gross Eric R ER Department of Anesthesiology, School of Medicine, Stanford University, Stanford, CA 94305, USA. - - 2013
Deciphering the remote conditioning molecular mechanism may provide targets to develop therapeutics that can broaden the clinical application. To further investigate this, we tested whether two protein kinase C (PKC) isozymes, the ubiquitously expressed epsilon PKC (εPKC) and the neuronal-specific gamma PKC (γPKC), mediate nociceptive-induced remote myocardial conditioning. Male Sprague-Dawley ...
Guan Jian J Divisions of Cardiovascular Medicine and Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, NRB 431, Boston, MA 02115, - - 2013
Immunoglobulin light chain (LC) amyloidosis (AL) results from overproduction of circulating amyloidogenic LC proteins and subsequent amyloid fibril deposition in organs. Mortality in AL amyloidosis patients is highly associated with a rapidly progressive AL cardiomyopathy, marked by profound impairment of diastolic and systolic cardiac function and significant early mortality. While ...
Shida Takuya - - 2013
Diabetic cardiomyopathy is associated with increased oxidative stress and vascular endothelial dysfunction, which lead to coronary microangiopathy. We tested whether statin-induced redox imbalance improvements could ameliorate diabetic cardiomyopathy and improve coronary microvasculature in streptozotocin-induced diabetes mellitus (DM). Fluvastatin (10 mg/kg/day) or vehicle was orally administered for 12 weeks to rats ...
Beigel Roy - - 2013
Although previous retrospective studies have suggested the clinical benefits of clopidogrel pretreatment in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI), the antiplatelet effect of thienopyridines during a narrow door-to-balloon time frame has not been evaluated. Seventy-nine consecutive patients with STEMI were treated with either 600 mg ...
Ellis Ethan R - - 2013
Congestive heart failure is a major health care concern affecting almost six million Americans and an estimated 23 million people worldwide, and its prevalence is increasing with time. Long-standing tachycardia is a well-recognized cause of heart failure and left ventricular dysfunction and has led to the nomenclature, tachycardia-induced cardiomyopathy. Tachycardia-induced ...
Fleet Richard R Department of Family Medicine Emergency Medicine, Université Laval, Quebec, Canada; Research Chair in Emergency Medicine, Université Laval-Hôtel-Dieu de Lévis, Quebec, Canada. Electronic address: - - 2014
We have previously reported that 35% CO2 challenge induced myocardial ischemia in 81% of coronary artery disease (CAD) patients with comorbid panic disorder (PD) and previous positive nuclear exercise stress tests. However, it is yet unclear whether this is the case among CAD patients with PD and normal nuclear exercise ...
Seifirad Soroush - - 2013
Compared to the normal population, patients with congestive heart failure are at higher risk for contrast-induced nephropathy. A variety of interventions are suggested to reduce the risk for contrast-induced nephropathy. Unfortunately results of none of current protective treatments are satisfactory. Apelin a vasodilator adipocytokine, positively inotropic agent, and free radical ...
Stankovic Ivan - - 2013
Contradicting reports have been published regarding the relation between a dobutamine-induced increase in either cardiac dyssynchrony or left-ventricular ejection fraction (LVEF) and the response to cardiac resynchronization therapy (CRT). Using apical rocking (ApRock) as surrogate dyssynchrony parameter, we investigated the dobutamine stress echocardiography (DSE)-induced changes in left-ventricular (LV) dyssynchrony and ...
Liu C-C - - 2013
To assess the beneficial effect of carvedilol treatment on infarct myocardium and the relation to the expression of nuclear factor-kappa B (NF-κB), Toll-like receptor 4 (TLR4), and β-arrestin 2. Rat myocardial infarction (MI) model was produced by ligating the left anterior descending coronary artery. Forty-eight rats were randomized to the ...
Yousefi Keyvan - - 2013
Isoproterenol injection (100 mg/kg; sc) produced changes in ECG pattern including ST-segment elevation and suppressed R-amplitude. The methanolic extract of M. vulgare at doses of 10, 20, and 40 mg/kg significantly amended the ECG changes. A severe myocardial necrosis and edematous along with a sharp reduction in the arterial blood ...
Osadchii Oleg E - - 2013
Procainamide is class Ia Na(+) channel blocker that may prolong ventricular repolarization secondary to inhibition of IK r , the rapid component of the delayed rectifier K(+) current. In contrast to selective IN a blockers such as lidocaine, procainamide was shown to produce arrhythmogenic effects in the clinical setting. This ...
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