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Stumpner Jan - - 2014
Cyclooxygenase (COX)-2 mediates ischemic pre- and postconditioning as well as anesthetic-induced preconditioning. However, the role of COX-1 and -2 in anesthetic-induced postconditioning has not been investigated. We evaluated the role of COX-1 and -2 in sevoflurane-induced postconditioning in vivo. Pentobarbital-anaesthetized male C57BL/6 mice were subjected to 45 minutes of coronary ...
Xu Xin-Ye XY Peking University Third Hospital, - - 2014
Accumulating evidence suggests that growth differentiation factor 15 (GDF-15) is associated with the severity and prognosis of various cardiovascular diseases. However, the effect of GDF-15 on the regulation of cardiac remodeling is still poorly understood. In this present study, we demonstrate that GDF-15 blocks norepinephrine(NE)-induced myocardial hypertrophy through a novel ...
Fransson Helen H Department of Clinical Physiology and Nuclear Medicine, Lund University, Lund University Hospital, 221 85, Lund, Sweden, - - 2014
Myocardial perfusion SPECT (MPS) is one of the frequently used methods for quantification of perfusion defects in patients with known or suspected coronary artery disease. This article describes open access software for automated quantification in MPS of stress-induced ischemia and infarction and provides phantom and in vivo validation. A total ...
Rolandi M Cristina MC Department of Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, Meibergdreef 9, P.O. Box 2270, 1105 AZ, Amsterdam, The - - 2014
Wave intensity analysis and wave separation are powerful tools for interrogating coronary, myocardial and microvascular physiology. Wave speed is integral to these calculations and is usually estimated by the single-point technique (SPc), a feasible but as yet unvalidated approach in coronary vessels. We aimed to directly measure wave speed in ...
Chen Chine-Hsi CH National Cheng Kung - - 2014
Intramyocardial injection of bone marrow mononuclear cells (MNCs) with hyaluronan (HA) hydrogel is beneficial to the ischemic heart in a rat model of myocardial infarction (MI). However, the therapeutic efficacy and safety must be addressed in large animals before moving onto a clinical trial. Therefore, the effect of the combined ...
Stams T R G TR Department of Medical Physiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, The - - 2014
The electromechanical window (EMW), the interval between the end of the T-wave and the end of the left ventricular pressure (LVP) curve, has recently been proposed as a predictor of risk of Torsade de Pointes (TdP) in healthy animals, whereby a negative EMW (mechanical relaxation earlier than repolarization) after drug ...
Roy Ambuj A Department of Cardiology, Cardiothoracic Centre, All India Institute of Medical Sciences, New Delhi 110029, - - 2014
We present a case of an elderly man with coronary artery disease who was diagnosed with non-Hodgkin lymphoma. Soon after the administration of chemotherapy, which included rituximab and vincristine, he developed acute myocardial infarction with cardiogenic shock. The condition was managed successfully with primary percutaneous coronary intervention. We briefly discuss ...
Wang Xiaohong X Department of Pharmacology and Cell - - 2014
Sepsis is the leading cause of death in critically ill patients. While myocardial dysfunction has been recognized as a major manifestation in severe sepsis, the underlying molecular mechanisms associated with septic cardiomyopathy remain unclear. In this study, we performed a miRNA array analysis in hearts collected from a severe septic ...
Xiong Q Q Cardiovascular Department, The Second Affiliated Hospital of Nanchang University, Nanchang, - - 2014
The human genome contains over 4 million variant sites, as compared with the reference genome, including rare sequence variants, which have the potential to exert large phenotypic effects, such as susceptibility to drug toxicity. We report identification and functional characterization of a rare non-synonymous (p.A1427S) variant in the SCN5A gene ...
Sweeney Michael O MO Brigham and Women's Hospital, Boston, MA; United States REVERSE Study Investigators. Electronic address: - - 2014
BV electrical wavefront fusion can induce improvement in LV size and function during CRT. Changes in BV wave propagation sequence and duration register in the QRS complex on the standard ECG. We derived a wave interference method for characterization of BV fusion to predict LV reverse remodeling. Develop a simple ...
Liu Shuangmei S Department of - - 2014
P2X3 receptors in stellate ganglia (SG) and cervical dorsal root ganglia (DRG) neurons are involved in sympathoexcitatory reflex induced by myocardial ischemic damage. Puerarin, a major active ingredient extracted from the traditional Chinese plant medicine Ge-gen, has been widely used in treatment of myocardial and cerebral ischemia. The present study ...
Yang Lifang L Department of Anesthesiology, Xi'an 710032, China; Center for Cardiovascular Research and Alternative Medicine, University of Wyoming, Laramie, WY 82071, - - 2014
Endoplasmic reticulum (ER) stress increases the risk of cardiovascular morbidity and mortality although the underlying mechanism remains elusive. This study was designed to examine the impact of cardiac over-expression of metallothionein, a cysteine-rich heavy metal scavenger, on ER stress-induced changes in myocardial function and underlying mechanism involved with a focus ...
Gurabi Zsolt Z 1Masonic Medical Research Laboratory, Utica, NY & Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, - - 2014
-Hypothermia has been reported to induce ventricular tachycardia and fibrillation (VT/VF) in patients with early repolarization (ER) pattern. This study examines the cellular mechanisms underlying VT/VF associated with hypothermia in an experimental model of ER syndrome (ERS) and examines the effectiveness of quinidine, cilostazol and milrinone to prevent hypothermia-induced arrhythmias. ...
Thangamalai Ramasamy R Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar-243122, Bareilly, Uttar Pradesh, India *Department of Biochemistry and Biotechnology, Annamalai University, Annamalai Nagar, Chidambaram, - - 2014
Impaired cardiac β-adrenoceptor signaling is an important cause of sepsis-induced myocardial depression in man and experimental animals. We examined the effect of atorvastatin pretreatment on myocardial β1-adrenoceptor (β1-AR) expressions and post-receptor signaling in a mouse model of sepsis (CLP; caecal ligation and puncture). After 20±2 h of surgery, hearts were ...
Sarusi Annamária A Department of Pharmacology and Pharmacotherapy, University of - - 2014
Predicting lethal arrhythmia liability from beat-to-beat variability and instability (BVI) of the ECG intervals is a useful technique in drug assessment. Most investigators use only arrhythmia-free ECGs for this. Recently, it was shown that drug-induced torsades de pointes (TdP) liability can be predicted more accurately from BVI measured irrespective of ...
Sun Aijun A Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China; Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China. Electronic address: - - 2014
Mitochondrial aldehyde dehydrogenase (ALDH2) protects against cardiac injury via reducing production of 4-hydroxynonenal (4-HNE) and ROS. This study was designed to examine the impact of ALDH2 on doxorubicin (DOX)-induced cardiomyopathy and mechanisms involved with a focus on autophagy. 4-HNE and autophagic markers were detected by Western blotting in ventricular tissues ...
Kiyooka Takahiko T Division of Cardiology, Tokai University Oiso Hospital, Oiso, Japan, - - 2014
A 60-year-old man was admitted with early morning angina while at rest. Coronary angiogram revealed no organic lesions; therefore, a spasm provocation test with ergonovine was performed. Administration of intracoronary ergonovine induced total occlusion of the right coronary artery. The induced total occlusion improved but coronary flow velocity remained severely ...
Verheyen F F CARIM, Maastricht University, Maastricht, The Netherlands; Electron Microscopy Unit at CRISP; Department of Molecular Cell Biology. Electronic address: - - 2014
Our goal was to show that blunting of myocardial flow reserve is mainly involved in adaptive chronic myocardial hibernation without apparent cardiomyocyte degeneration. Sheep chronically instrumented with critical multivessel stenosis and/or percutaneous transluminal coronary angioplasty (PTCA)-induced revascularization were allowed to run and feed in the open for 2 and 5 ...
Burashnikov Alexander A Masonic Medical Research Laboratory, Utica, NY, - - 2014
Heart failure (HF) is associated with development of AF and life-threatening ventricular tachycardia and fibrillation (VT/VF). Vulnerability to development of AF and VT/VF at different stages of HF and the underlying pathophysiological mechanisms are poorly defined. The present study was designed to determine the time-course of development of electrical and ...
Casella Michela M Cardiac Arrhythmia Research Centre, Centro Cardiologico Monzino, IRCCS, Via Parea, 4, 20138, Milan, Italy, - - 2014
Ephedrine is a sympathomimetic substance used by sportsmen as a doping substance because of its stimulating and slimming effects. We report two cases of ventricular arrhythmias induced by abuse of ephedrine in two competitive athletes. Endomyocardial biopsies guided by electroanatomic mapping revealed contraction-band necrosis, a myocardial injury frequently observed in ...
Tanabe Kan K Department of Cardiology, Kanazawa Medical University, Ishikawa, - - 2014
Endothelial dysfunction of the coronary arteries caused by oxidative stress plays an important role in the pathogenesis of coronary vasospasm. However, it is not clear whether circulating biomarkers for oxidative stress are altered after coronary vasospasm. We investigated temporal changes in the levels of oxidative stress biomarkers after coronary vasospasm ...
Valenta Ines - - 2014
Increases in intra-abdominal visceral adipose tissue have been widely appreciated as a risk factor for metabolic disorders such as dyslipidemia, hypertension, insulin resistance, and type 2 diabetes, whereas this is not the case for peripheral or subcutaneous obesity. While the underlying mechanisms that contribute to these differences in adipose tissue ...
Wang Bao-Wei BW School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan ; Division of Cardiology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, - - 2014
MicroRNA-208a (mir-208a) is essential for cardiac hypertrophy and fibrosis. Endoglin, a co-receptor of transforming growth factor-β is also essential for cardiac fibrosis. Endoglin has been shown to be a target of mir-208a in the in vitro mechanical stress model. Volume overload can lead to heart failure and cardiac fibrosis. The ...
Lim Kyu Hee KH 1 Department of Veterinary Physiology, College of Veterinary Medicine, Biosafety Research Institute, Chonbuk National University , Jeonju City, Jeollabuk-Do, - - 2014
Abstract Red ginseng (RG, Panax ginseng) has been shown to possess various ginsenosides. These ginsenosides are widely used for treating cardiovascular diseases in Asian communities. The present study was designed to evaluate the cardioprotective potential of RG against isoproterenol (ISO)-induced myocardial infarction (MI), by assessing electrocardiographic, hemodynamic, and biochemical parameters. ...
Schuhmann Christoph G CG Department of Cardiology, Medizinische Klinik I, Munich, - - 2014
Elevated levels of myeloperoxidase (MPO) have been found in patients in different stages of coronary artery disease (CAD). The aim of this study was to assess whether the MPO liberation is increased by stress inducible myocardial ischemia and could be used to improve the diagnostic accuracy of non-invasive evaluation for ...
Matsumoto Naoya N Department of Cardiology, Nihon University Surugadai Hospital, Tokyo, - - 2014
We present the case of coronary vasospasm during adenosine stress in a patient with a prior drug-eluting stent implantation. The patient had a stent implantation in the left anterior descending coronary artery 3 years ago. Recently, he developed a chest pain and underwent adenosine stress myocardial perfusion single photon emission ...
Oikawa Shota S Division of Clinical Pathophysiology, Graduate School of Health Sciences, Fujita Health University, 1-98 Dengakugakubo Kutsukake, Toyoake, - - 2014
Objectives. Doxapram hydrochloride is a respiratory stimulant that has an inhibitory effect on myocardial IK1 potassium channels and is thought to increase membrane instability and excitability in myocardial cells. We examined the arrhythmogenic effects of doxapram hydrochloride in a rat model of halothane adrenaline-induced arrhythmia. Methods. Thirteen female Wistar rats ...
Sundbøll Jens J Department of Cardiology, Aarhus University Hospital, Skejby, Aarhus N, - - 2014
A 67-year-old man underwent surgery under general anaesthesia to obtain a biopsy from a tumour in the left maxillary sinus. Before the procedure a mucosal detumescence containing epinephrine and cocaine was applied onto the nasal mucosa. Shortly after termination of anaesthesia the patient developed tachycardia and an abrupt rise in ...
Shamloul Reham Mohammed RM Department of Neurology, Cairo University, Cairo, - - 2014
We report a case of a 37-year-old man presented with acute stroke and hepatorenal impairment which were associated with anabolic-androgenic steroids (AAS) abuse over 2 years. Despite the absence of apparent symptoms and signs of congestive heart failure at presentation, an AAS-induced dilated cardiomyopathy with multiple thrombi in the left ...
Arora P P Senior Consultant Cardiology, Fortis Hospital, Noida, India. Electronic address: - - 2014
Adenosine is commonly used as a pharmacological agent in myocardial perfusion imaging, as an antiarrhythmic agent, and in Cath Lab. during PCI for treating no reflow phenomenon. Coronary spasm has been reported following adenosine injection during stress imaging. We report a rare complication with ST segment elevation, following adenosine injection, ...
Nakayama Naoki N Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, - - 2014
The prevalence, clinical features, and long-term outcome of patients with non-ST-segment elevation acute coronary syndrome (NSTE ACS) associated with coronary spasm are not fully investigated. This observational multicenter study enrolled 1601 consecutive patients with suspected NSTE-ACS who underwent cardiac catheterization between January 2001 and December 2010. A culprit lesion was ...
Baek Jin Hyen JH Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA. - - 2014
Endotoxemia plays a major causative role in the myocardial injury and dysfunction associated with sepsis. Extracellular hemoglobin (Hb) has been shown to enhance the pathophysiology of endotoxemia. In the present study, we examined the myocardial pathophysiology in guinea pigs infused with lipopolysaccharide (LPS), a Gram-negative bacterial endotoxin, and purified Hb. ...
LenĨová-Popelová Olga O Department of Pharmacology, Faculty of Medicine in Hradec Králové, Charles University in Prague, Hradec Králové, Czech - - 2014
Chronic anthracycline cardiotoxicity is a serious clinical issue with well characterized functional and histopathological hallmarks. However, molecular determinants of the toxic damage and associated myocardial remodeling remain to be established. Furthermore, details on the different propensity of the left and right ventricle (LV and RV, respectively) to the cardiotoxicity development ...
Fernández-Ruiz Irene I Tumor Immunology Lab, IdiPAZ, Hospital La Paz, Madrid, Spain; Innate Immunity Group, IdiPAZ, La Paz Hospital, Madrid, - - 2014
Monocyte exposure to mitochondrial Danger Associated Molecular Patterns (DAMPs), including mitochondrial DNA (mtDNA), induces a transient state in which these cells are refractory to further endotoxin stimulation. In this context, IRAK-M up-regulation and impaired p65 activity were observed. This phenomenon, termed endotoxin tolerance (ET), is characterized by decreased production of ...
Qiu Qi Q Capital Medical University Beijing An Zhen Hospital, Beijing 100029, - - 2014
We aim to investigate the therapeutic effects of QSYQ on a pig myocardial ischemia (MI) model and to determine its mechanism of action. The MI model was induced by Ameroid constriction of the left anterior descending coronary (LAD) in Ba-Ma miniature pigs. Four groups were created: model group, digoxin group, ...
Rujic Dragana D Department of Internal Medicine, Odense University Hospital, Svendborg Hospital, Valdemarsgade 53, 5700 Svendborg, - - 2014
Muscle overlying an intramyocardial segment of a coronary artery is termed a myocardial bridge. The intramyocardial segment, the tunneled artery, is compressed during systole. The condition is generally benign but may occasionally cause myocardial ischemia, infarction, arrhythmia, or sudden cardiac death. We present a case regarding a 52-year-old man with ...
Mostarda Cristiano C Federal University of Maranhao (UFMA) São Luis, Maranhão, - - 2014
Baroreflex dysfunction has been considered an important mortality predictor after myocardial infarction (MI). However, the impact of baroreflex deficiency prior to MI on tonic autonomic control and cardiac function, and on the profile of proteins associated with intracellular calcium handling has not yet been studied. The aim of the present ...
Ugur Murat M Clinic of Cardiology, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Center Training and Research Hospital, Istanbul, - - 2014
Background Hemoglobin concentration (Hb) and left ventricular ejection fraction (EF) are known predictors of contrast induced nephropathy (CIN). We hypothesized that combination of Hb concentration and left ventricular EF is superior to either variable alone in predicting contrast induced nephropathy in patients with acute coronary syndrome (ACS). Material and Methods ...
Hirose Masamichi M Department of Molecular and Cellular Pharmacology, Iwate Medical University School of Pharmaceutical - - 2014
Phlorizin is a type of flavonoids and has a peroxynitrite scavenging effect. This study aimed to elucidate the effects of phlorizin on ischemia-induced ventricular tachyarrhythmia (VT). Optical signals from the epicardial surface of the ventricle or left ventricular end diastolic pressure (LVEDP) were recorded during acute global ischemia in 42 ...
Golias Christos - - 2014
Oral capecitabine is an oral prodrug of 5-fluorouracil that has been integrated into the management of multiple cancer types because of the convenience of administration and its efficacy compared with 5-fluorouracil. Capecitabine mimics the pharmacokinetics of intravenous 5-fluorouracil. While cardiac events associated with the use of 5-fluorouracil are a well-known ...
Wang Rui R Institute for Cardiovascular Diseases, Union Hospital, Huazhong University of Science and Technology, Wuhan, P. R. - - 2014
Cardiac hypertrophy increases the risk of morbidity and mortality of cardiovascular disease and thus inhibiting such hypertrophy is beneficial. In the present study, we explored the effect of a bioactive peptide (PAP) on angiotensin II (Ang II)-induced hypertrophy and associated ventricular arrhythmias in in vitro and in vivo models. PAP ...
Velagic V V Department for Cardiovascular Diseases, University Hospital Centre Zagreb, - - 2014
Heparin-induced thrombocytopenia is an immune-mediated serious adverse effect of heparin therapy. It is a relatively frequent complication among patients with mechanical circulatory support. Herein, we present a patient with severe heart failure and sepsis who developed heparin-induced thrombocytopenia shortly after implantation of left ventricular assist device as a bridge to ...
Rodrigues Bruno B Human Movement Laboratory, Sao Judas Tadeu University (USJT), Avenida Taquari 546, 03166-000 São Paulo, SP, - - 2014
The cardiovascular autonomic imbalance in patients after myocardial infarction (MI) provides a significant increase in mortality rate, and seems to precede metabolic, hormonal, and immunological changes. Moreover, the reduction in the parasympathetic function has been associated with inflammatory response in different pathological conditions. Over the years, most of the studies ...
Sreckovic Miodrag Jovan MJ Department of Interventional Cardiology, Clinical Center Kragujevac, Kragujevac, - - 2014
Coronary artery spasm is sometimes an unrecognized cause of myocardial ischemia. Myocardial ischemia is not always a product of fixed stenosis; it can also be induced by dynamic, transient stenosis. The angiogram represents the current state of vasculature at the time of examination and absence of stenosis does not mean ...
Goto Masayuki M Cardiology, Tachikawa General Hospital, - - 2014
A 64-year-old woman underwent a coronary flow reserve evaluation using intracoronary-administered papaverine into the left anterior descending artery. Her baseline electrocardiogram (ECG) was normal, but toward the end of papaverine administration, the QTU intervals were excessively prolonged and torsade de pointes occurred, leading to ventricular fibrillation. Ten months previously, the ...
Penna Claudia C Department of Clinical and Biological Sciences, University of Turin, Torino, - - 2014
In the presence of comorbidities the effectiveness of many cardioprotective strategies is blunted. The goal of this study was to assess in a hypertensive rat model if the early reperfusion with anti-hypertensive and pro-angiogenic Chromogranin A-derived peptide, Catestatin (CST:hCgA352-372; CST-Post), protects the heart via Reperfusion-Injury-Salvage-Kinases (RISK)-pathway activation, limiting infarct-size and ...
Dominguez Luis W LW 0000-0002-9580-7899 Department of Internal Medicine, Jersey City Medical Center, 355 Grand Street, Jersey City, NJ 07302, USA ; St. George's University School of Medicine, St. George's, - - 2014
A 46-year-old African-American male with past medical history significant for Kartagener's syndrome, essential hypertension, and HIV presented with acute chest pain. ECG and troponins indicated an acute myocardial infarction. Ventriculography confirmed dyskinesia of the left ventricle, with an EF of 25%. However the coronary catheterization showed nonobstructed coronaries. Ventricular contraction ...
Hinrichs Jan B JB Hanover Medical School, Institute for Diagnostic and Interventional Radiology, Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research, Integrated Research and Treatment Center Transplantation (IFB-Tx), Hannover, - - 2014
There is a need to expand knowledge on cardio-pulmonary pathophysiology of bronchiolitis obliterans syndrome (BOS) following lung transplantation (LTx). The purpose of this study was to assess MRI-derived biventricular cardiac mass and function parameters as well as flow hemodynamics in patients with and without BOS after LTx. Using 1.5T cardiac ...
Zaman Sarah S Westmead Hospital & University of Sydney, Sydney, - - 2013
A negative electrophysiology study (EPS) may delineate a sub-group of patients with severely impaired left ventricular ejection fraction (LVEF) who are safe long-term without an implantable-cardioverter defibrillator (ICD). Consecutive patients treated with primary percutaneous coronary intervention for ST-elevation myocardial infarction (STEMI) underwent early (median 4 days) LVEF assessment. Patients with ...
Koncz István I Department of Molecular Genetics and Experimental Cardiology, Masonic Medical Research Laboratory, 2150 Bleecker St., Utica, NY, 13501, USA; Department Experimental Cardiology, Masonic Medical Research Laboratory, 2150 Bleecker St., Utica, NY, 13501, USA; Department of Pharmacology & Pharmacotherapy, University of Szeged, H-6721 Szeged, Dóm tér 12, - - 2013
Early repolarization pattern in the ECG has been associated with increased risk for ventricular tachycardia/fibrillation (VT/VF), particularly when manifest in inferior leads. This study examines the mechanisms underlying VT/VF in the early repolarization syndrome (ERS). Transmembrane action potentials (AP) were simultaneously recorded from 2 epicardial and 1 endocardial site of ...
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