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Volo Samuel C SC Greenberg Cardiology Division, Department of Medicine, Weill Cornell Medical College, New York, New - - 2014
Mitral regurgitation (MR) is common with coronary artery disease as altered myocardial substrate can affect valve performance. Single-photon emission computed tomography myocardial perfusion imaging (MPI) enables assessment of myocardial perfusion alterations. This study examined perfusion pattern in relation to MR. A total of 2,377 consecutive patients with known or suspected ...
Börekçi Abdurrezzak A Department of Cardiology, School of Medicine, Kafkas University, Kars, - - 2014
Reactive oxygen species have been implicated in the pathogenesis of contrast-induced nephropathy (CIN). We investigated the relationship between CIN with paraoxonase 1 (PON-1) activity and oxidative stress markers (total antioxidant status [TAS], total oxidant status [TOS], and oxidative stress index [OSI]) in patients with anterior ST-segment elevation myocardial infarction (STEMI) ...
Silberbauer John J Arrhythmia Unit and Electrophysiology Laboratories, Ospedale San Raffaele, Milan, - - 2014
-Successful late potential (LP) abolition and post-procedural ventricular tachycardia (VT) non-inducibility constitute significant endpoints after catheter ablation for VT. We investigated the prognostic impact of a combined procedural endpoint of VT non-inducibility and LP abolition in a large series of post-myocardial infarction (MI) patients with VT. -160 (154 male, 94% ...
Yamazaki Katrina Go KG California State University Los Angeles, Department of Biological Sciences, Los Angeles, CA, United States; University of California San Diego, United States. Electronic address: - - 2014
Targeting the mitochondria during ischemia/reperfusion (IR) can confer cardioprotection leading to improved clinical outcomes. The cardioprotective potential of (-)-epicatechin (EPI) during IR via modulation of mitochondrial function was evaluated. Ischemia was induced in rats via a 45min occlusion of the left anterior descending coronary artery followed by 1h, 48h, or ...
Ke Tingyu T Department of Endocrinology, the Second Affiliated Hospital, Kunming Medical University,, Kunming, China ; - - 2014
Aim: Netrin-1 is typically known as a neuronal guidance factor. Studies later reported pro-angiogenenic, anti-apoptotic and anti-inflammatory properties of Netrin-1. A critical role of Netrin-1 in ischaemic organ damages, myocardiac infarction (MI) in particular, was also demonstrated, making Netrin-1 a potential therapeutic target for cardiovascular diseases. Mesenchymal stem cells (MSCs) ...
Ussher John R JR Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, - - 2014
GLP-1R agonists improve outcomes in ischemic heart disease. Here we studied GLP-1R-dependent adaptive and cardioprotective responses to ventricular injury. Glp1r (-/-) hearts exhibited chamber-specific differences in gene expression, but normal mortality and left ventricular (LV) remodeling after myocardial infarction (MI) or experimental doxorubicin-induced cardiomyopathy. Selective disruption of the cardiomyocyte GLP-1R ...
Edmondson E F EF Flint Animal Cancer Center, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, - - 2014
Pheochromocytoma-associated catecholamine-induced cardiomyopathy is a well-known entity in man, nonhuman primates, and mice but has not been described in dogs. In this retrospective study, 9 dogs were identified with pheochromocytomas and concurrent cardiovascular pathology observed histologically (n = 6), echocardiographically (n = 4), and/or electrocardiographically (n = 5). Cardiac lesions ...
Sahu Bidya Dhar BD Medicinal Chemistry and Pharmacology Division, CSIR-Indian Institute of Chemical Technology (IICT), Hyderabad-500 007, - - 2014
Preventive and/or therapeutic interventions using natural products for ischemic heart disease have gained considerable attention worldwide. This study investigated the cardioprotective effect and possible mechanism of embelin, a major constituent of Embelia ribes Burm, using isoproterenol (ISO)-induced myocardial infarction model in rats. Rats were pretreated for three days with embelin ...
Padhy Mamta M Department of Biochemistry, Maulana Azad Medical College, New Delhi 110002, - - 2014
Contrast-induced acute kidney injury (AKI) is diagnosed by estimating serum creatinine at 48-72h after diagnostic or interventional coronary angiography. It is too late for an early intervention. Neutrophil gelatinase associated lipocalin (NGAL) and cystatin C are novel markers of AKI. We determined the optimum cut off level of NGAL and ...
Yuasa Sho S Tachikawa General Hospital, Cardiology, Nagaoka, - - 2014
The patient was a 33-year-old male. Twenty years ago, he underwent radiofrequency catheter ablation for idiopathic sustained monomorphic ventricular tachycardia (VT) with an RBBB and superior axis pattern. The VT was inducible by programmed stimulation and entrained by rapid pacing. At this presentation, he developed palpitation and VT with the ...
Sun Bing B Department of Cardiology, Tongji Hospital, Tongji University, Shanghai, P.R. - - 2014
Heptanol is a type of gap junction inhibitor that decreases electrical conduction velocity. However, little is known regarding the effects of heptanol on the arrhythmias induced by regional myocardial ischemia. This study aimed to investigate the effects of heptanol on ventricular arrhythmias and the underlying mechanisms. On the Langendorff apparatus, ...
Zhou Hai-Yan HY aSir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310016, China bDepartment of Pharmacology, Zhejiang Medical College, Hangzhou, 310053, China cDepartment of Pathology and Pathophysiology, Zhejiang University School of Medicine, Hangzhou, 310058, - - 2014
Levosimendan is a calcium-sensitizing agent shown to prevent myocardical contractile depression in various heart diseases. In the present study we investigated the effect of levosimendan on cardiac dysfunction and apoptosis in hypothermic preservation rat hearts. Isolated rat hearts were preserved in Celsior solution with or without levosimendan. The left ventricular ...
Ruan Lei L Department of Gerontology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. - - 2014
Drug-induced torsades de pointes (TdP) is common with class III antiarrhythmic drugs. Increased transmural dispersion of repolarization (TDR) contributes significantly to the development of TdP. Gap junctions play an important role in maintaining TDR in long QT syndrome. The present study examined the effect of a gap junction enhancer, antiarrhythmic ...
O'brien Laura C LC Department of Physiology and Biophysics, Virginia Commonwealth University, Richmond, VA, - - 2014
Interleukin 18 (IL-18) is a proinflammatory cytokine in the interleukin-1 (IL-1) family that has been implicated in a number of disease states. In animal models of acute myocardial infarction (AMI), pressure overload, and LPS induced dysfunction IL-18 regulates cardiomyocyte hypertrophy, induces cardiac contractile dysfunction and extracellular matrix remodeling. In patients, ...
Besnier Marie M *Institut National de la Santé et de la Recherche Médicale (INSERM) U1096, Rouen, - - 2014
The protein tyrosine phosphatase 1B (PTP1B) modulates tyrosine kinase receptors, among which is the vascular endothelial growth factor receptor type 2 (VEGFR2), a key component of angiogenesis. Because PTP1B deficiency in mice improves left ventricular (LV) function 2 mo after myocardial infarction (MI), we hypothesized that enhanced angiogenesis early after ...
Winklhofer Sebastian S Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Switzerland; Institute of Forensic Medicine, University of Zurich, - - 2014
The aim of this study was to quantify the response of the myocardial transverse relaxation times (ΔT2 *) to hyperoxic respiratory challenge (HRC) at different field strengths in an intra-individual comparison of healthy volunteers and in a patient with coronary artery disease. Blood oxygenation level-dependent (BOLD) cardiovascular MR (CMR) data ...
Le Grand Bruno B Institut de Recherche Pierre Fabre, Castres Cedex, France, - - 2014
Atrial fibrillation (AF) is a common complication of heart failure. The aim of the present study was to investigate the effects of a new pure docosahexaenoic acid derivative called F 16915 in experimental models of heart failure-induced atria dysfunction. The atrial dysfunction-induced AF was investigated (1) in a dog model ...
Duran Jason M JM Cardiovascular Research Center, Temple University School of - - 2014
Sorafenib is an effective treatment for renal cell carcinoma, but recent clinical reports have documented its cardiotoxicity through an unknown mechanism. Determining the mechanism of sorafenib-mediated cardiotoxicity. Mice treated with sorafenib or vehicle for 3 weeks underwent induced myocardial infarction (MI) after 1 week of treatment. Sorafenib markedly decreased 2-week ...
Thayssen Per P From the Department of Cardiology, Odense University Hospital, Odense, Denmark (P.T., K.N.H., H.S.H., A.J., K.T.V., L.O.J.); Department of Cardiology, Aarhus University Hospital, Skejby, Denmark (J.F.L., E.H.C., L.T.); and Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark (S.E.J., - - 2014
Contrast-induced nephropathy (CIN) is a serious condition in patients with ST-segment-elevation myocardial infarction treated with primary percutaneous coronary intervention. We compared the risk of acute CIN and the influence of preventive strategies in patients with ST-segment-elevation myocardial infarction undergoing primary percutaneous coronary intervention. A total of 720 patients were randomized ...
Aykan Hayrettin Hakan HH Department of Pediatric Cardiology, Faculty of Medicine, İhsan Doğramacı Childrens Hospital, Hacettepe University; Ankara-Turkey. - - 2014
Tachycardia-induced cardiomyopathy (TIC) is a rare but potentially curable cause of dilated cardiomyopathy. Data on radiofrequency ablation (RFA) for TIC is limited. The aim of this study is to present our experience with RFA in children with TIC, retrospectively. The medical records of patients with TIC and those underwent RFA ...
Tare Marianne M Monash University, - - 2014
Intrauterine growth restriction (IUGR) is associated with impaired cardiac function in childhood and is linked to short and long-term morbidities. Placental dysfunction underlies most IUGR, and causes fetal oxidative stress which may impact on cardiac development. Accordingly, we investigated whether antenatal melatonin treatment, which possesses antioxidant properties, may afford cardiovascular ...
Monceau Virginie V INSERM U1030, LabEx LERMIT, Villejuif, France; Faculté de Médecine Paris-Sud, Université Paris-Sud 11, Le Kremlin-Bicêtre, - - 2014
Cardiac toxicity is a side-effect of anti-cancer treatment including radiotherapy and this translational study was initiated to characterize radiation-induced cardiac side effects in a population of breast cancer patients and in experimental models in order to identify novel therapeutic target. The size of the heart was evaluated in CO-HO-RT patients ...
Roy Ranjini Raina RR Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Scottsdale, Arizona - - 2014
Apical akinesis and dilation in the absence of obstructive coronary artery disease is a typical feature of stress-induced (takotsubo) cardiomyopathy, whereas apical hypertrophy is seen in apical-variant hypertrophic cardiomyopathy. We report the cases of 2 patients who presented with takotsubo cardiomyopathy and were subsequently found to have apical-variant hypertrophic cardiomyopathy, ...
Krantz David S DS Department of Medical and Clinical Psychology (D.S.K.) Uniformed Services University of the Health Sciences Bethesda, Maryland Department of Medicine (M.M.B.) Columbia University Medical Center New York, New York and Department of Medicine Yale University School of Medicine (M.M.B.) New Haven, - - 2014
Mental stress and emotional arousal can act as triggers of myocardial infarction and other adverse cardiovascular outcomes. This editorial presents an overview of the research on mental stress-induced myocardial ischemia (MSIMI) and comments on two investigations examining MSIMI published in this journal. These studies confirm that MSIMI is frequently observed ...
Satendra Milan M Serviço de Cardiologia, Hospital Santa Maria, Centro Hospitalar Lisboa Norte, Lisboa, Portugal. Electronic address: - - 2014
Pheochromocytoma is a tumor originating from chromaffin tissue. It commonly presents with symptoms and signs of catecholamine excess, such as hypertension, tachycardia, headache and sweating. Cardiovascular manifestations include catecholamine-induced cardiomyopathy, which may present as severe left ventricular dysfunction and congestive heart failure. We report a case of pheochromocytoma which was ...
Mathison Megumi M Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, - - 2014
The in situ reprogramming of cardiac fibroblasts into induced cardiomyocytes by the administration of gene transfer vectors encoding Gata4 (G), Mef2c (M), and Tbx5 (T) has been shown to improve ventricular function in myocardial infarction models. The efficacy of this strategy could, however, be limited by the need for fibroblast ...
Zaman Sarah S Department of Cardiology, Westmead Hospital, Sydney, Australia; Department of Medicine, University of Sydney, - - 2014
The prognostic significance of a second programmed ventricular stimulation (PVS) at electrophysiology study (EPS), when the first PVS is negative for inducible ventricular tachycardia (VT), in patients following myocardial infarction (MI) is unknown. Consecutive ST-elevation MI patients with left ventricular ejection fraction ≤40% following revascularization underwent early EPS. An implantable ...
Yang Qiong Q Department of Cardiology, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, P.R. - - 2014
Myocardial tissue injury caused by ischemia and hypoxia is a major cause of fatal diseases, including coronary atherosclerosis resulting from myocardial infarction and stroke. A number of microRNAs have been demonstrated to function as protectors against ischemia‑reperfusion (I/R) and/or hypoxia‑reperfusion (H/R)‑induced myocardial injury, including microRNA‑21 (miR‑21). However, the protective mechanism ...
Zhou Xiang X Department of Cardiology, The Second Affiliated Hospital of Soochow University, No. 1055 Sanxiang Road, Suzhou, 215004, Jiangsu, China, - - 2014
The present study was designed to investigate the protective effects of hydrogen sulfide (H2S) against cigarette smoking-induced left ventricular dysfunction in rats. Left ventricular structure and function were assessed using two-dimensional echocardiography. Cardiomyocyte apoptosis was determined by Annexin V/PI and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling staining. Cardiac autophagy ...
Theis Cathrin C From the II. Medical Clinic, Department of Electrophysiology, University Medical Center, Johannes Gutenberg-University, Mainz, - - 2014
Implantable cardioverter defibrillators (ICD) may have the capacity to provoke or worsen ventricular tachyarrhythmias (VT). It has been reported that ICD shocks by itself can increase mortality. This study aimed to determine the role of back-up pacing-induced VT (PIT) in the overall ICD shock burden by avoiding pause-related ventricular back-up ...
Yin Honglei H Department of Cardiology Ward 1, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan 453100, P.R. - - 2014
The inflammatory response has adverse effects on left ventricular (LV) function and remodeling post-myocardial infarction (MI). Interleukin (IL)-33 is considered to have anti-inflammatory properties. The present study examined whether the suppression of inflammation with IL-33 was able to attenuate LV dysfunction and remodeling post-MI. The MI model was induced and ...
Merlocco Anthony C AC The Division of Cardiology, Department of Paediatrics, Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, ON, M5G1X8, - - 2014
Remote ischemic preconditioning (rIPC) induced by transient limb ischemia (li-rIPC) leads to neurally dependent release of blood-borne factors that provide potent cardioprotection. We hypothesized that transcutaneous electrical nerve stimulation (TENS) is a clinically relevant stimulus of rIPC. Study 1: seven rabbits were subjected to lower limb TENS; six to li-rIPC, ...
Ersboll Mads M Department of Medicine, Duke University Medical Center, Durham, North Carolina. Electronic address: - - 2014
The aim of this study was to investigate the association between resting myocardial function as assessed by tissue Doppler myocardial velocities and the propensity to develop mental stress-induced ischemia (MSIMI). Tissue Doppler myocardial velocities detect preclinical cardiac dysfunction and clinical outcomes in a range of conditions. However, little is known ...
Homma Satoshi S Division of Cardiovascular Medicine, Department of Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan. Electronic address: - - 2014
Calcitonin gene-related peptide (CGRP) is a potent vasodilator neuropeptide. We investigated the ameliorating effect of CGRP in myocardial ischemia induced by endothelin-1 (ET-1), with special emphasis on myocardial microvascular hemodynamics and levels of energy-related metabolites. Langendorff preparations of rat isolated heart were perfused at a constant flow rate. Microvascular blood ...
Piers Sebastiaan R D SR Department of Cardiology, Leiden University Medical Centre, Leiden, the - - 2014
Specific 12-lead ECG criteria have been reported to predict an epicardial site of origin (SoO) of induced ventricular tachycardias (VTs) in left ventricular nonischemic cardiomyopathy (NICM). This study aimed to (1) determine the value of ECG criteria to predict an epicardial SoO of clinically documented VTs, (2) analyze the effect ...
Wang Xiaohui X Department of Surgery, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN - - 2014
The present study examined the role of microRNA-125b (miR-125b) in myocardial I/R injury. We constructed lentivirus expressing miR-125b (LmiR-125b) and developed transgenic mice with overexpression of miR-125b.Material and MethodsLmiR-125b was transfected into mouse hearts through the right common carotid artery. Lentivirus vector (LmiR-Con) served as vector control. Untreated mice served ...
Chopra Nagesh N Arrhythmia Service, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, - - 2014
MR-imaging has shown that infarct scars causing VT can extend deep to and beyond bipolar low voltage areas (LVA) and may be a source of ablation failure. We hypothesized that the size of the unipolar LVA 'penumbra' beyond the overlying bipolar scar may predict outcome of endocardial VT ablation. Twenty ...
Sridharan Vijayalakshmi V a University of Arkansas for Medical Sciences, Department of Pharmaceutical Sciences, Division of Radiation Health, Little Rock, - - 2014
Radiation therapy for the treatment of thoracic cancers may be associated with radiation-induced heart disease (RIHD), especially in long-term cancer survivors. Mechanisms by which radiation causes heart disease are largely unknown. To identify potential long-term contributions of mitochondria in the development of radiation-induced heart disease, we examined the time course ...
Stumpner Jan - - 2014
Cyclooxygenase (COX)-2 mediates ischemic pre- and postconditioning as well as anesthetic-induced preconditioning. However, the role of COX-1 and -2 in anesthetic-induced postconditioning has not been investigated. We evaluated the role of COX-1 and -2 in sevoflurane-induced postconditioning in vivo. Pentobarbital-anaesthetized male C57BL/6 mice were subjected to 45 minutes of coronary ...
Xu Xin-Ye XY Peking University Third Hospital, - - 2014
Accumulating evidence suggests that growth differentiation factor 15 (GDF-15) is associated with the severity and prognosis of various cardiovascular diseases. However, the effect of GDF-15 on the regulation of cardiac remodeling is still poorly understood. In this present study, we demonstrate that GDF-15 blocks norepinephrine(NE)-induced myocardial hypertrophy through a novel ...
Fransson Helen H Department of Clinical Physiology and Nuclear Medicine, Lund University, Lund University Hospital, 221 85, Lund, Sweden, - - 2014
Myocardial perfusion SPECT (MPS) is one of the frequently used methods for quantification of perfusion defects in patients with known or suspected coronary artery disease. This article describes open access software for automated quantification in MPS of stress-induced ischemia and infarction and provides phantom and in vivo validation. A total ...
Rolandi M Cristina MC Department of Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, Meibergdreef 9, P.O. Box 2270, 1105 AZ, Amsterdam, The - - 2014
Wave intensity analysis and wave separation are powerful tools for interrogating coronary, myocardial and microvascular physiology. Wave speed is integral to these calculations and is usually estimated by the single-point technique (SPc), a feasible but as yet unvalidated approach in coronary vessels. We aimed to directly measure wave speed in ...
Chen Chine-Hsi CH National Cheng Kung - - 2014
Intramyocardial injection of bone marrow mononuclear cells (MNCs) with hyaluronan (HA) hydrogel is beneficial to the ischemic heart in a rat model of myocardial infarction (MI). However, the therapeutic efficacy and safety must be addressed in large animals before moving onto a clinical trial. Therefore, the effect of the combined ...
Stams T R G TR Department of Medical Physiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, The - - 2014
The electromechanical window (EMW), the interval between the end of the T-wave and the end of the left ventricular pressure (LVP) curve, has recently been proposed as a predictor of risk of Torsade de Pointes (TdP) in healthy animals, whereby a negative EMW (mechanical relaxation earlier than repolarization) after drug ...
Roy Ambuj A Department of Cardiology, Cardiothoracic Centre, All India Institute of Medical Sciences, New Delhi 110029, - - 2014
We present a case of an elderly man with coronary artery disease who was diagnosed with non-Hodgkin lymphoma. Soon after the administration of chemotherapy, which included rituximab and vincristine, he developed acute myocardial infarction with cardiogenic shock. The condition was managed successfully with primary percutaneous coronary intervention. We briefly discuss ...
Wang Xiaohong X Department of Pharmacology and Cell - - 2014
Sepsis is the leading cause of death in critically ill patients. While myocardial dysfunction has been recognized as a major manifestation in severe sepsis, the underlying molecular mechanisms associated with septic cardiomyopathy remain unclear. In this study, we performed a miRNA array analysis in hearts collected from a severe septic ...
Xiong Q Q Cardiovascular Department, The Second Affiliated Hospital of Nanchang University, Nanchang, - - 2014
The human genome contains over 4 million variant sites, as compared with the reference genome, including rare sequence variants, which have the potential to exert large phenotypic effects, such as susceptibility to drug toxicity. We report identification and functional characterization of a rare non-synonymous (p.A1427S) variant in the SCN5A gene ...
Sweeney Michael O MO Brigham and Women's Hospital, Boston, MA; United States REVERSE Study Investigators. Electronic address: - - 2014
BV electrical wavefront fusion can induce improvement in LV size and function during CRT. Changes in BV wave propagation sequence and duration register in the QRS complex on the standard ECG. We derived a wave interference method for characterization of BV fusion to predict LV reverse remodeling. Develop a simple ...
Liu Shuangmei S Department of - - 2014
P2X3 receptors in stellate ganglia (SG) and cervical dorsal root ganglia (DRG) neurons are involved in sympathoexcitatory reflex induced by myocardial ischemic damage. Puerarin, a major active ingredient extracted from the traditional Chinese plant medicine Ge-gen, has been widely used in treatment of myocardial and cerebral ischemia. The present study ...
Yang Lifang L Department of Anesthesiology, Xi'an 710032, China; Center for Cardiovascular Research and Alternative Medicine, University of Wyoming, Laramie, WY 82071, - - 2014
Endoplasmic reticulum (ER) stress increases the risk of cardiovascular morbidity and mortality although the underlying mechanism remains elusive. This study was designed to examine the impact of cardiac over-expression of metallothionein, a cysteine-rich heavy metal scavenger, on ER stress-induced changes in myocardial function and underlying mechanism involved with a focus ...
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