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Sundbøll Jens J Department of Cardiology, Aarhus University Hospital, Skejby, Aarhus N, - - 2014
A 67-year-old man underwent surgery under general anaesthesia to obtain a biopsy from a tumour in the left maxillary sinus. Before the procedure a mucosal detumescence containing epinephrine and cocaine was applied onto the nasal mucosa. Shortly after termination of anaesthesia the patient developed tachycardia and an abrupt rise in ...
Shamloul Reham Mohammed RM Department of Neurology, Cairo University, Cairo, - - 2014
We report a case of a 37-year-old man presented with acute stroke and hepatorenal impairment which were associated with anabolic-androgenic steroids (AAS) abuse over 2 years. Despite the absence of apparent symptoms and signs of congestive heart failure at presentation, an AAS-induced dilated cardiomyopathy with multiple thrombi in the left ...
Arora P P Senior Consultant Cardiology, Fortis Hospital, Noida, India. Electronic address: - - 2014
Adenosine is commonly used as a pharmacological agent in myocardial perfusion imaging, as an antiarrhythmic agent, and in Cath Lab. during PCI for treating no reflow phenomenon. Coronary spasm has been reported following adenosine injection during stress imaging. We report a rare complication with ST segment elevation, following adenosine injection, ...
Baek Jin Hyen JH Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA. - - 2014
Endotoxemia plays a major causative role in the myocardial injury and dysfunction associated with sepsis. Extracellular hemoglobin (Hb) has been shown to enhance the pathophysiology of endotoxemia. In the present study, we examined the myocardial pathophysiology in guinea pigs infused with lipopolysaccharide (LPS), a Gram-negative bacterial endotoxin, and purified Hb. ...
Zaman Sarah S Westmead Hospital & University of Sydney, Sydney, - - 2013
A negative electrophysiology study (EPS) may delineate a sub-group of patients with severely impaired left ventricular ejection fraction (LVEF) who are safe long-term without an implantable-cardioverter defibrillator (ICD). Consecutive patients treated with primary percutaneous coronary intervention for ST-elevation myocardial infarction (STEMI) underwent early (median 4 days) LVEF assessment. Patients with ...
Koncz István I Department of Molecular Genetics and Experimental Cardiology, Masonic Medical Research Laboratory, 2150 Bleecker St., Utica, NY, 13501, USA; Department Experimental Cardiology, Masonic Medical Research Laboratory, 2150 Bleecker St., Utica, NY, 13501, USA; Department of Pharmacology & Pharmacotherapy, University of Szeged, H-6721 Szeged, Dóm tér 12, - - 2013
Early repolarization pattern in the ECG has been associated with increased risk for ventricular tachycardia/fibrillation (VT/VF), particularly when manifest in inferior leads. This study examines the mechanisms underlying VT/VF in the early repolarization syndrome (ERS). Transmembrane action potentials (AP) were simultaneously recorded from 2 epicardial and 1 endocardial site of ...
Gabel Eilon E Department of Anesthesiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, - - 2013
Cardiomyopathy secondary to toxic shock syndrome (TSS) is an uncommon but potentially life-threatening problem. We report the case of a 51-year-old male who presented with profound cardiogenic shock and multiorgan failure that could not be managed by conventional therapy with intravenous fluids, vasopressors and inotropes. Venoarterial extracorporeal membrane oxygenation (VA ...
Macarthur John W JW Jr Surgery, University of Pennsylvania School of - - 2013
Following myocardial infarction (MI) there is an inadequate blood supply to the myocardium and the surrounding borderzone becomes hypocontractile. To develop a clinically translatable therapy, we hypothesized that in a preclinical ovine model of MI, the modified endothelial progenitor stem cell (EPC) chemokine, engineered stromal cell-derived factor 1-alpha analogue (ESA), ...
Chou Chung-Chuan CC Division of Cardiology, Department of Medicine, Chang Gung Memorial Hospital, Linko, Taiwan; Chang Gung University College of Medicine, Taoyuan, Taiwan. Electronic address: - - 2013
Piceatannol, a hydroxystilbene natural product, has been reported to exert antiarrhythmic action via INa inhibition and slow INa inactivation in ischemia-reperfused (IR) rat hearts. The present study aimed to clarify the proarrhythmic property of piceatannol during regional IR injury in failing rabbit hearts. Heart failure (HF) was induced by rapid ...
Sun Xianlin X Department of Cardiology, Anhui Provincial Hospital of Anhui Medical University, Hefei, PR - - 2013
Background: Glutamate mediates cerebral ischemia injury via N-methyl-D-aspartate (NMDA) receptor-coupled ion channels, but the activities of glutamate in the heart remain unclear. Aims: To investigate whether or not glutamate contributes to ischemia- and reperfusion (IR)-induced arrhythmias. Methods: Myocardial IR was induced by occlusion of the left anterior descending coronary artery ...
Rijnierse Mischa T MT 1VU University Medical Center, Amsterdam, the - - 2013
-Risk stratification for ventricular arrhythmias (VA) is important to refine selection criteria for primary prevention implantable cardioverter defibrillator (ICD) therapy. Impaired hyperemic myocardial blood flow (MBF) is associated with increased mortality rate in ischemic and non-ischemic cardiomyopathy, which may be attributed to electrical instability inducing VA. The aim of this ...
Datta Sandipan S Department of Pharmacognosy, ‡National Center for Natural Products Research, and ⊥Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi , University, Mississippi 38677, United - - 2013
Certain botanical dietary supplements have been associated with idiosyncratic organ-specific toxicity. Similar toxicological events, caused by drug-induced mitochondrial dysfunction, have forced the withdrawal or U.S. FDA "black box" warnings of major pharmaceuticals. To assess the potential mitochondrial liability of botanical dietary supplements, extracts from 352 authenticated plant samples used in ...
Pei Xiao - - 2013
Doxorubicin is an effective chemotherapeutic agent used to treat malignancies but it causes cardiomyopathy. This study examined the cellular effects of desacyl ghrelin on myocardial fibrosis and apoptosis in a doxorubicin cardiomyopathy experimental model. Adult C57BL/6 mice received an intraperitoneal injection of doxorubicin to induce cardiomyopathy, followed by 4-day treatment ...
Takahashi M - - 2013
An application of photodynamic therapy for myocardial ablation, which would induce myocardial electrical conduction block, is proposed. For the proposed application, an extracellular photosensitization reaction (PR) is performed while photosensitizer is distributed in myocardial interstitial space by employing a short drug-light interval. Because the myocardial necrosis depth must be accurately ...
Polderman Kees H - - 2013
This article discusses the potential of levosimendan to treat calcium-induced myocardial dysfunction associated with deep hypothermia. Moderate hypothermia (30 to 34°C) usually improves myocardial contractility and stabilizes heart rhythm, but deep hypothermia can cause severe myocardial dysfunction, which is mediated by intracellular calcium overload. In experimental studies, levosimendan appears effective ...
Drobnik J J Laboratory of Connective Tissue Metabolism, Medical University of Lodz, Lodz, Poland. - - 2013
Elevated levels of collagen as well as transient increases of glycosaminoglycans (GAG) have been shown in the myocardium remote to the infarction. The aim of the study is to observe the effect of melatonin on the accumulation of collagen and GAG in the left ventricle wall, remote to the infarction. ...
Vocelka Craig R - - 2013
Little is known about the effect of cardiopulmonary bypass alone on cardiac function; in an attempt to illuminate this relationship and test a possible mechanism, we used Cytosorb, a device capable of removing virtually all types of circulating cytokines to test the hypothesis that hemoadsorption of cytokines during bypass attenuates ...
Marunouchi Tetsuro - - 2013
It is generally accepted that an increase in the myocardial level of heat-shock protein 72 (HSP72) protects viable cardiac tissue against myocardial infarction (MI)-induced stress. However, the induction of HSP72 after exposure to heat shock (HS) is blunted in the failing rat heart following MI. The mechanisms underlying this impairment ...
Pezhouman Arash - - 2013
Enhanced late inward Na current (INa-L) modulates action potential duration (APD) and plays a key role in the genesis of early and delayed afterdepolarizations (EADs & DADs) and triggered activity. To define the influence of selective block of the INa-L on EAD- & DAD-mediated triggered ventricular tachycardia and fibrillation (VT ...
Mao Jianqiang - - 2013
Cell therapy has emerged as an attractive therapeutic modality to treat myocardial infarction (MI) via repairing damaged myocardium, and mesenchymal stem cells (MSCs) are an appealing therapeutic approach for cardiac regeneration. However, the clinical application of MSC-based therapy is restricted because of the poor survival of implanted cells, and this ...
Chou Chung-Chuan - - 2013
Dantrolene prevents arrhythmogenic Ca(2+) release during heart failure (HF). However, direct evidence to support its antiarrhythmic effects in failing hearts with acute myocardial infarction (AMI) is lacking. HF was induced by right ventricular pacing (312 bpm, 4 weeks) in 19 rabbits. AMI was induced by coronary artery ligation in rabbits ...
Yalin Kivanc - - 2013
The extent of peri-infarct zone (PIZ) by contrast-enhanced cardiac magnetic resonance (ce-CMR) has been related to inducibility of ventricular arrhythmia in patients with ischemic cardiomyopathy. However, this relationship has not been established in postmyocardial infarction (post-MI) patients with relatively reserved left ventricular (LV) systolic function yet. In this study, we ...
Casals Gregori - - 2013
Background: The molecular mechanisms by which myocardial ischemia translates into ventricular remodeling remain unclear. Methods: We investigated whether hypoxia and proinflammatory cytokines are specific inducers of remodeling signals in an in vitro model of cultured adult human ventricular myocytes (AC16 cells). Results: Hypoxia modified the ratio of matrix remodeling factors ...
Nordin Charles - - 2013
Hypoglycemia increases the risk for both overall and sudden death. At a cellular level, hypoglycemia causes alterations in the physiology of myocardial tissue that are identical to proarrhythmic medications. Reduced serum glucose blocks the repolarizing K(+) channel HERG, which leads to action potential and QT prolongation and is uniformly associated ...
Chrastina Adrian - - 2013
We describe a novel model of myocardial infarction (MI) in rats induced by percutaneous transthoracic low-energy laser-targeted photodynamic irradiation. The procedure does not require thoracotomy and represents a minimally invasive alternative to existing surgical models. Target cardiac area to be photodynamically-irradiated was triangualted from the thoracic X-ray scans. The acute ...
Dinov Borislav - - 2013
Data on the outcomes of ventricular tachycardia (VT) ablation in non-ischemic dilated cardiomyopathy (NIDCM) are insufficient. The HEART CENTRE OF LEIPZIG VT (HELP-VT) STUDY WAS PROSPECTIVELY CONDUCTED TO COMPARE OUTCOMES AFTER RADIOFREQUENCY CATHETER ABLATION (RFCA) OF VT IN PATIENTS WITH NIDCM AS COMPARED TO ISCHEMIC CARDIOMYOPATHY (ICM). Two hundred and ...
Li Yu-Juan - - 2013
Salvia miltiorrhiza (SM, also known as DanShen) is one of the well-known widely-used Chinese herbal medicines in clinical, containing phenolic compounds and potent antioxidant properties. Salvianolic acid A (SAA)is the most potent component of SM. A modern experimental strategy for treating myocardial ischemia is to induce neovascularization of the heart ...
Armaganijan Luciana - - 2013
Abnormal ventricular repolarization has been proposed as a marker of arrhythmogenesis, and cardiovascular morbidity and mortality. However, little is known about the influence of the interval between the peak and the end of the T wave (Tp-Te) on the inducibility of sustained ventricular arrhythmias (VA) in patients with Chagas disease ...
Bohora Shomu S U.N.Mehta Institute of Cardiology and Research Centre, - - 2013
A 13 year old boy having idiopathic ventricular tachycardia had non-inducible tachycardia twice on electrophysiology (EP) study due to suppression of arrhythmia by local anaesthetic agent, lignocaine. This case report demonstrates a cause of non-inducibility or arrhythmia during EP study and effect of lignocaine in suppression of idiopathic ventricular tachycardia.
Carballeira Pol Lidia - - 2013
Frequent ventricular premature depolarizations (VPDs) can cause cardiomyopathy (CMP). The mechanisms underlying its development remain unclear with VPD burden only a weak predictor of risk. Among individuals with normal left ventricular ejection fraction (LVEF), we sought to determine whether VPD QRS duration at time of initial presentation could predict risk ...
Ramadan Ronnie - - 2013
ObjectiveMental stress provokes myocardial ischemia in many patients with stable coronary artery disease (CAD). Mental stress-induced myocardial ischemia (MSIMI) portends a worse prognosis, independent of standard cardiac risk factors or outcome of traditional physical stress testing. Angiotensin II plays a significant role in the physiological response to stress, but its ...
Akutsu Yasushi - - 2013
A 72-year-old female was diagnosed as a stress-induced cardiomyopathy from apical ballooning pattern of left ventricular dysfunction without coronary artery stenosis after the mental stress. ECG showed the transient T-wave inversions after the ST-segment elevations. By the mental stress after 1 year, she showed a transient dysfunction with similar ECG ...
Meserve Emily E - - 2013
Abstract We present a clinicopathologic study of the youngest reported child with lethal cyclophosphamide-induced cardiotoxicity following hematopoietic stem cell transplantation for β-thalassemia major and the first to report the use of extracorporeal membrane oxygenation (ECMO) as a therapeutic modality to bridge the patient to myocardial recovery. Despite improvement of myocardial ...
Hsieh Calvin H C - - 2013
-Ventricular tachycardia (VT) is a significant complication of myocardial infarction. Radiofrequency ablation (RFA) for post-infarct VT is reserved for drug refractory VT or VT storms. Our hypothesis is that RFA in the early post-infarct period could abolish or diminish late recurrences of VT. -Myocardial infarct was induced by balloon occlusion ...
Augustine Daniel D From the Oxford Cardiovascular Clinical Research Facility, University of Oxford, Oxford, United Kingdom (D.A., E.L., L.N., A.J.L., E.F.D., P.L.); and Department of Clinical Immunology, Oxford University Hospitals NHS Trust, Oxford, United Kingdom (L.V.A., - - 2014
Microparticles are cell-derived membrane vesicles, relevant to a range of biological responses and known to be elevated in cardiovascular disease. To investigate microparticle release during cardiac stress and how this response differs in those with vascular disease. We measured a comprehensive panel of circulating cell-derived microparticles by a standardized flow ...
Lu Chen - - 2013
Innate immune and inflammatory responses mediated by Toll like receptors (TLRs) have been implicated in myocardial ischemia/reperfusion (I/R) injury. This study examined the role of TLR3 in myocardial injury induced by two models, namely, myocardial infarction (MI) and I/R. First, we examined the role of TLR3 in MI. TLR3 deficient ...
Kolettis Theofilos M - - 2013
Abstract Background: The relative role of acute myocardial ischemia and infarction in ventricular arrhythmogenesis is incompletely understood. We compared the arrhythmia pattern after ischemia/infarction to that observed after direct myocardial necrosis without preceding ischemia in rats. Methods: Coagulation necrosis was induced in Wistar rats (n=20, 280±3 g) by radiofrequency current ...
Costa José F - - 2013
Short periods of myocardial ischemia followed by reperfusion induce a cardioprotective mechanism when the myocardium is subsequently subjected to a prolonged period of ischemia, a phenomenon known as ischemic preconditioning. As well as its application in the myocardium, ischemic preconditioning can also be induced by brief interruptions of blood flow ...
Cai Zheqing - - 2013
Both preclinical and clinical studies suggest that brief cycles of ischemia and reperfusion in the arm or leg may protect the heart against injury following prolonged coronary artery occlusion and reperfusion, a phenomenon known as remote ischemic preconditioning. Recent studies in mice indicate that increased plasma interleukin-10 (IL-10) levels play ...
Wang Wen-Long - - 2013
Abnormal enhanced transmural dispersion of repolarization (TDR) plays an important role in the maintaining of the severe ventricular arrhythmias such as torsades de pointes (TDP) which can be induced in long-QT (LQT) syndrome. Taking advantage of an in vitro rabbit model of LQT2, we detected the effects of KN-93, a ...
Lee Wonho W Department of Internal Medicine, Kangwon National University Hospital, Chuncheon, - - 2013
Amiodarone is a widely used antiarrhythmic agent. Among its various adverse effects, amiodarone-induced pulmonary toxicity (APT) is the most life threatening complication, which has been described mostly in patients who have been in treatment with high accumulative doses for a long duration of time. However, amiodarone therapy in short-term duration ...
Ramadan Ronnie R Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, - - 2013
Mental stress-induced myocardial ischemia (MSIMI) is associated with adverse prognosis in patients with coronary artery disease (CAD), yet the mechanisms underlying this phenomenon remain unclear. We hypothesized that compared with exercise/pharmacological stress-induced myocardial ischemia (PSIMI) that is secondary to the atherosclerotic burden of CAD, MSIMI is primarily due to vasomotor ...
Wu Xiaoqian - - 2013
The mechanisms underlying the myocardial protection of valsartan against ischemia/reperfusion (I/R) injury are complicated and remain unclear. The aim of this study was to investigate whether autophagy machinery was involved in the protection against I/R injury that is induced by valsartan. In vivo rat hearts were subjected to ischemia by 30 min ...
Zhao Yu-Juan - - 2013
To evaluate the effect of high thoracic epidural analgesia (HTEA) in congestive heart failure (CHF). Rat model of CHF. Harbin Medical University, Harbin, Heilongjiang, China. One hundred thirty-five rats. HTEA involved 5 times daily injections of 0.1% lidocaine at the T3-T4 level. The authors examined myocardial norepinephrine (NE), angiotensin II ...
Zhou Qina - - 2013
The epicardial fat pad (FP) integrates the autonomic innervation between the extrinsic and intrinsic cardiac autonomic nervous system and affects atrial electrophysiology and pathophysiology. Eighteen dogs were divided into two groups: sequential ablation of sinoatrial node FP (SAN-FP) and atrioventricular node FP (AVN-FP). Sinus rate (SR), atrial fibrillation (AF) inducibility, ...
Pouliopoulos Jim - - 2013
Collagen has been attributed as the principle structural substrate of ventricular tachycardia (VT) post-myocardial infarction (MI) even though adiposity of myocardium post-MI is well recognised histologically. We investigated the association of intramyocardial adiposity in comparison to collagen on electrophysiological (EP) properties, connexin-43 (Cx43) expression, and VT induction post-MI. Simultaneous, left ...
Hsieh Calvin H C - - 2013
-Sudden arrhythmic death post myocardial infarction (MI) is most frequent in the first month. Early programmed ventricular stimulation (PVS) (within 1 week) post-MI has been able to identify longterm ventricular tachycardia (VT) occurrence. We aimed to determine the timing of development and stabilization of VT circuits following MI, and how ...
Meng Jing - - 2013
Impaired ventricular repolarization can lead to long QT syndrome (LQT), a proarrhythmic disease with high risk of developing lethal ventricular tachyarrhythmias. The compound ICA-105574 is a recently developed hERG activator and it enhances IKr current with very high potency by removing the channel inactivation. The present study was designed to ...
Queenthy S Sharmila - - 2013
The aim of the present study was to evaluate the protective effects of diosmin on experimentally induced myocardial infarcted rats. Diosmin (5 and 10mg/kg body weight) was administered orally as pretreatment daily for a period of 10 days. Then isoproterenol (100mg/kg) was injected subcutaneously into rats at an interval of ...
Khorrami A - - 2013
Myocardial infarction (MI) was induced by subcutaneous injection of isoproterenol (ISO) to investigate the effect of ISO on Coenzyme Q10 (CoQ10) content of myocardium and subsequent effects on lipid peroxidation, electrocardiogram pattern and hemodynamic parameters of the rat's heart.36 male Wistar rats were divided randomly into 6 groups. To induce ...
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