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Kurhanewicz Nicole - - 2014
BackgroundStudies have shown a relationship between air pollution and increased risk of cardiovascular morbidity and mortality. Due to the complexity of ambient air pollution composition, recent studies have examined the effects of co-exposure, particularly particulate matter (PM) and gas, to determine whether pollutant interactions alter (e.g. synergistically, antagonistically) the health ...
Wu S-I SI Department of Psychiatry, Mackay Memorial Hospital, Taipei, Taiwan; Department of Audiology and Speech Language Pathology, Mackay Medical College, Taipei, - - 2014
To investigate the association between acute myocardial infarction (AMI) and recent exposure to antipsychotic agents in people with serious mental illness (SMI), and modifying influences. A case-crossover design was applied using the Taiwan National Health Insurance Research Database (NHIRD) to compare the exposure frequency of antipsychotic agents within individuals of ...
Dallocchio Carlo C *Division of Neurology, and †Department of Radiology, Ospedale Civile, Voghera, Pavia, - - 2014
Etoricoxib is a newer cyclooxygenase (COX)-2 inhibitor anti-inflammatory drug with a favorable safety profile. However, several randomized trials have provided evidence of an increased risk for acute myocardial infarction associated with the use of COX-2 inhibitors. Fewer data are available concerning the risk for ischemic stroke associated with COX-2 inhibitors. ...
Huang Tianfang T Department of Pharmacology and Toxicology College of Pharmacy, University of Arizona, Tucson AZ - - 2014
Arsenic exposure during embryonic development can cause ischemic heart pathologies later in adulthood which may originate from impairment in proper blood vessel formation. The arsenic associated detrimental effects are mediated by arsenite (iAs(III)) and its most toxic metabolite, monomethylarsonous acid [MMA (III)]. The impact of MMA (III) on coronary artery ...
Enzensberger C C Department of OB&GYN, Philipps University, Division of Prenatal Medicine, - - 2014
Objectives: Fetal cardiac function can be quantified by different methods. This is the first approach of real three-dimensional(3 D)-based speckle tracking echocardiography in the fetus to assess different cardiac strain parameters. Methods: We present preliminary results of fetal global myocardial strain analyses. For fetal echocardiography a Toshiba Artida system was used. ...
Barros Fernanda Silveira Bello FS Department of Obstetrics, Paulista School of Medicine - Federal University of São Paulo (EPM-UNIFESP), São Paulo, - - 2014
Objective: To establish the reference range of the myocardial wall area in the fetus using three-dimensional ultrasound in the rendering mode. Methods: A prospective, cross-sectional study including 371 singleton, uncomplicated pregnancies at 20 weeks 0 day to 33 weeks 6 days of gestation was carried out. Cardiac volumes were obtained ...
Beroukhim Rebecca S RS Department of Pediatric/Congenital Cardiology, Massachusetts General Hospital for Children, Boston, MA; Department of Cardiology, Boston Children's Hospital, Boston, - - 2014
We investigated perinatal outcomes after fetal diagnosis of single ventricle cardiac defects. 'Single ventricle' was defined as a dominant RV or LV, in which biventricular circulation was not possible. We reviewed patients with a fetal diagnosis of single ventricle cardiac defect at one institution from 1995-2008. Diagnoses such as double-inlet ...
Tian Xueying X Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, - - 2014
The postnatal coronary vessels have been viewed as developing through expansion of vessels formed during the fetal period. Using genetic lineage tracing, we found that a substantial portion of postnatal coronary vessels arise de novo in the neonatal mouse heart, rather than expanding from preexisting embryonic vasculature. Our data show ...
Krishnan Anita A Children's National Heart Institute, Children's National Medical Center, Department of Cardiology, Washington, DC, 20010, - - 2014
Echocardiography screening in anti-SSA antibody exposed fetuses is controversial. Evaluate utility of fetal echocardiography in anti-SSA exposure. Echocardiograms done over 9 years for maternal anti-SSA exposure were reviewed for AV block, cardiomyopathy, arrhythmias, effusion, valve abnormalities, or other abnormalities identified by the echocardiographer. Fetuses with AV block referred to our ...
van Engelen Klaartje K Department of Clinical Genetics, Academic Medical Center, Amsterdam, The - - 2014
Introduction: Bicuspid aortic valve (BAV) is common in Turner syndrome (TS). In adult TS, 82-95% of BAVs have fusion of the right and left coronary leaflets. Data in fetal stages are scarce. The purpose of this study was to gain insight into aortic valve morphology and associated cardiovascular abnormalities in ...
Al Darazi Fahed F 1Division of Cardiovascular Diseases, Department of Medicine 2Department of Microbiology, Immunology & Biochemistry 3Department of Obstetrics & Gynecology 4Division of Endocrinology, Department of Medicine, University of Tennessee Health Science Center, Memphis, TN, - - 2014
With the perspective of functional myocardial regeneration, we investigated small cardiomyocytes bordering on microdomains of fibrosis, where they are dedifferentiated re-expressing fetal genes, and determined: i) whether they are atrophied segments of the myofiber syncytium; ii) their redox state; iii) their anatomic relationship to activated myofibroblasts (myoFb), given their putative ...
Lee Mi-Young MY Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, - - 2014
To report our experiences in the prenatal diagnosis of atrial isomerism and postnatal outcomes. A total of 80 fetuses prenatally diagnosed with atrial isomerism were retrospectively analyzed between 1999 and 2011 at a single institution. Of 43 fetuses with prenatally diagnosed right atrial isomerism (RAI), 40 cases were analyzed. The ...
Yozgat Yilmaz Y Department of Pediatric Cardiology, Dr Behcet Uz Children's Hospital, Izmir, - - 2014
Abstract Objectives: We prospectively investigated the efficacy of modified myocardial performance index (mod-MPI) in the assessment of cardiac functions in fetuses with and without an isolated hyperechogenic focus (IHF) in the left ventricle and compared with conventional fetal echocardiography. Methods: The study group consisted of 50 fetuses with only an ...
Park Sung Min SM School of Medicine, Kangwon National University, Chuncheon, - - 2014
The ventricular electrocardiogram (v-ECG) was developed for long-term monitoring of heartbeats in patients with a left ventricular assist device (LVAD) and does not normally have the functionality necessary to detect additional heart irregularities that can progress to critical arrhythmias. Although the v-ECG has the benefits of physiological optimization and counterpulsation ...
Raquel Mula M Maternal-Fetal Medicine Department. Hospital Clínic, Universitat de Barcelona, Barcelona, - - 2014
The aim of this study was to assess fetal cardiac function in first trimester trisomy 21 fetuses as compared with fetuses with other aneuploidies, euploid fetuses with cardiac defects or isolated increased nuchal translucency and controls. During a 2-year period,nuchal translucency (NT), ductus venosus (DV) blood flow, diastolic filling time ...
Cole Charles R CR Division of Molecular Cardiovascular Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH - - 2014
Structural congenital heart disease (CHD) has not previously been linked to autoimmunity. In our study, we developed an autoimmune model of structural CHD that resembles hypoplastic left heart syndrome (HLHS), a life-threatening CHD primarily affecting the left ventricle. Because cardiac myosin (CM) is a dominant autoantigen in autoimmune heart disease, ...
Gao Xiaoqian X Department of Pharmacology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA. - - 2014
Bisphenol A (BPA) is a ubiquitous plasticizing agent used in the manufacturing of polycarbonate plastics and epoxy resins. There is well-documented and broad human exposure to BPA. The potential risk that BPA poses to the human health has attracted much attention from regulatory agencies and the general public, and has ...
Gao Yuping Y First Hospital of Shanxi Medical University, Taiyuan 030001, China ; The Affiliated Dayi Hospital of Shanxi Medical University, Taiyuan 030032, - - 2014
The pathophysiological mechanisms of heart failure (HF) stems were mainly from longstanding overactivation of the sympathetic nervous system and renin-angiotensin-aldosterone system. Recent studies highlighted the potential benefits of β1-adrenoceptor (β1-AR) blocker combined with β2-adrenergic receptor (β2-AR) agonist in patients with HF. Long-term exposure to fine particulate air pollution, such as ...
Freitas Fernando F Toxicology Laboratory, Department of Clinical and Toxicological Analysis, Federal University of Rio Grande do Sul, Porto Alegre, RS 90610-000, Brazil. - - 2014
Several studies have associated exposure to environmental pollutants, especially polycyclic aromatic hydrocarbons (PAHs), with the development of cardiovascular diseases. Considering that 1-hydroxypyrene (1-OHP) is the major biomarker of exposure to pyrenes, the purpose of this study was to evaluate the potential association between 1-OHP and oxidative stress/inflammatory biomarkers in patients ...
Ishii Tetsuko - - 2013
Objective: The impact of prenatal intervention on fetal cardiac function has not been well defined. We assessed standard ventricular function parameters and strain in fetuses with evolving hypoplastic left heart syndrome (HLHS) treated with fetal aortic valvuloplasty (fAVP). Methods: Fetuses with valvar aortic stenosis that underwent fAVP were studied. Echocardiographic ...
Cuneo Bettina F - - 2013
The electrophysiology of long QT syndrome (LQTS) in utero is virtually unstudied. Our goal here was to evaluate the efficacy of fetal magnetocardiography (fMCG) for diagnosis and prognosis of fetuses at risk of LQTS. We reviewed the pre/postnatal medical records of 30 fetuses referred for fMCG because of a family ...
Saini Ashish P - - 2013
Quantitative assessment of fetal heart function has been difficult. Increasingly, tissue Doppler imaging (TDI) is used to measure fetal cardiac function noninvasively. There are two principal techniques, spectral pulsed wave (PW) TDI and color TDI (CTDI). Published reference values for fetal myocardial velocities are based on spectral PW TDI only. ...
Bader Rima S - - 2013
Atrioventricular septal defects (AVSD) are very commonly diagnosed in utero. Heterotaxy/chromosomal abnormalities frequently coexist with AVSD. However, outcomes of fetal AVSD are not precisely known. We attempted to define mortality risk factors in AVSD. We retrospectively searched our database, electronic records, and echocardiograms with diagnosis of fetal AVSD from 2003 ...
Elmstedt Nina Ne - - 2013
Objectives: Myocardial function can be evaluated using color-coded tissue velocity imaging (TVI) to analyze the longitudinal myocardial velocity profile, and by expressing the motion of the atrioventricular plane during a cardiac cycle as coordinated events in the cardiac state diagram (CSD). The objective of this study was to establish gestational ...
Hofsteen Peter P Department of Pharmaceutical Sciences, University of Wisconsin, 777 Highland Ave, Madison, WI 53705, - - 2013
Zebrafish (Danio rerio) are an excellent vertebrate model for studying heart development, regeneration and cardiotoxicity. Zebrafish embryos exposed during the temporal window of epicardium development to the aryl hydrocarbon receptor (AHR) agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exhibit severe heart malformations. TCDD exposure prevents both proepicardial organ (PE) and epicardium development. Exposure later ...
Kalish Brian T - - 2013
The objective of this study was to describe our single-institution experience with prenatal atrial septal stent placement for fetuses with hypoplastic left heart syndrome and an intact atrial septum (HLHS/IAS). Infants born with HLHS/IAS are at high risk for neonatal death, despite maximal postnatal therapy. Prenatal atrial septoplasty by static ...
Iwashima Satoru - - 2013
BACKGROUND: Our goal was to evaluate the serial change in myocardial performance from fetus to neonate using tissue Doppler imaging (TDI). METHOD AND RESULTS: There were 37 term infants in the present study. The TDI sensor was placed at the level of the lateral mitral annulus (M-TDI), inter-ventricular septum (IVS-TDI) ...
Altug Nahide - - 2013
OBJECTIVE: To draw attention to the left ventricular false tendon which can be misinterpreted as echogenic focus in the fetus. METHODS: The study group consisted of 9 fetuses out of the 161 who had been misdiagnosed for left ventricular false tendon as echogenic focus by obstetricians. Fetal echocardiography and 2-D ...
Natarajan Shobha - - 2013
BACKGROUND: Right ventricular mechanics influence outcomes in patients with hypoplastic left heart syndrome (HLHS). The aim of this study was to determine whether differences in right ventricular performance have their origins in fetal life and if the architectural character of the hypoplastic left ventricle affects right ventricular mechanics. METHODS: The ...
Tan Monica - - 2013
AIM: Atrioventricular septal defect (AVSD) is widely accepted as the most common type of congenital heart defect in trisomy 21. Most of these studies, however, were conducted in Caucasian communities. The few Asian studies that had been conducted on this subject yielded different results. In the largest study of its ...
Rodriguez Roberto - - 2013
PURPOSE OF REVIEW: The present article aims to review recent literature about intracardiac echogenic foci (ICEFs), with special emphasis in potential causes, relationships with aneuploidy and cardiac function. RECENT FINDINGS: The presence of an ICEF may be considered as a soft marker that may be of interest only in high-risk ...
Terry Jefferson - - 2013
Abstract Aortico-left ventricular tunnel (ALVT) is a rare congenital heart anomaly of unclear pathogenesis causing left ventricular volume overload. Most descriptions are from surgical corrections in the neonatal and infantile period and little is known about ALVT in utero. Here we describe a case of ALVT ending in intrauterine demise ...
Merz Waltraut M - - 2013
We analyzed the association between renal and cardiovascular parameters in fetuses with isolated severe urinary tract malformations. 39 fetuses at a mean gestational age of 23.6 weeks with nephropathies or urinary tract malformations and markedly impaired or absent renal function were prospectively examined. Fetal echocardiography was performed, and thicknesses of ...
Mekkaoui Choukri - - 2013
Human myocardium has a complex and anisotropic 3D fiber pattern. It remains unknown, however, when in fetal life this anisotropic pattern develops and whether the human heart is structurally fully mature at birth. We aimed here to use diffusion tensor MRI (DTI) tractography to characterize the evolution of fiber architecture ...
Jin Zhu - - 2013
Epidemiological studies have demonstrated that offspring born to mothers preeclampsia (PE) are at increased risk for developing cardiovascular diseases after birth, but the underlying mechanism is unknown. Angiotensin II receptor type 1 autoantibody (AT1-AA), an agonist acting via activation of the AT1 receptor, is believed to be involved in the ...
García-Díaz Lutgardo L Unidad de Gestión Clínica de Genética, Reproducción y Medicina Fetal, Instituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Rocío, CSIC, Universidad de Sevilla, 41013 Sevilla, - - 2013
A case of prenatally diagnosed fetal hypertrophic cardiomyopathy is reported. The mother was referred to our department at 37 weeks' gestation because of suspected congenital heart disease. Prenatal echocardiography showed biventricular hypertrophy and pericardial effusion, without additional abnormalities. Postnatal echocardiography confirmed prenatal diagnosis. Neonatal EKG showed biventricular hypertrophy and Wolff-Parkinson-White ...
Junno Juulia - - 2012
OBJECTIVE: In a sheep model we tested the hypothesis that the fetal left ventricle is less tolerant to worsening acidemia than the right ventricle. STUDY DESIGN: At 106-124/145 days of gestation, 12 fetuses were instrumented. After a 4-day recovery, placental vascular resistance was increased by fetal angiotensin (AT) II infusion. ...
A Calvert Patrick - - 2012
Radiofrequency intravascular ultrasound uses radiofrequency backscatter data to determine the sub-plaque anatomy and composition of coronary atherosclerosis and hence permits plaque classification. The thin-capped fibroatheroma is associated with future major adverse cardiovascular events, emphasizing its biological importance.
Truong Uyen T - - 2012
BACKGROUND: In postnatal life, patients with single ventricle (SV) with morphologic right ventricles have a worse prognosis than those with morphologic left ventricles. The aim of this study was to test the hypotheses that (1) the SV in fetuses with SV has decreased longitudinal strain compared with fetuses with normal ...
Miguelote R F - - 2012
OBJECTIVES: To compare cortical maturation between fetuses with isolated mild ventriculomegaly (IMV) and healthy fetuses, and to explore its potential prognostic value in IMV. METHODS: This prospective study quantified cortical maturation by ultrasound in 24 fetuses with IMV and 46 healthy fetuses. Depth and grading the developmental pattern of the ...
Davey B - - 2012
Heart failure can be defined as the inability of the heart to sufficiently support the circulation. In the fetus, heart failure can be caused by a myriad of factors that include fetal shunting abnormalities, genetic cardiomyopathies, extracardiac malformations, arrhythmias and structural congenital heart disease. With advances in ultrasound has come ...
Wang Kimberley C W - - 2012
In vitro studies using rat and fetal sheep cardiomyocytes indicate that, in addition to its role as a clearance receptor, the insulin-like growth factor 2 receptor (IGF-2R) can induce cardiomyocyte hypertrophy. In the present study, we have determined the effect of specific activation of the IGF-2R in the heart of ...
McCarthy Fenton H - - 2012
BACKGROUND: Stentless porcine bioroots and pericardial composite roots were developed as prostheses that avoid the anticoagulation necessary for mechanical composite roots. Data on the hemodynamics of all root replacements are lacking and questions remain regarding comparative performance. METHODS: This study evaluated patients receiving a stentless porcine bioroot, a pericardial, or ...
Simioni Christiane - - 2012
OBJECTIVE: To compare the cardiac output (CO) and ejection fraction (EF) of the heart of male and female fetuses obtained by 3D-ultrasonography using spatio-temporal image correlation (STIC). METHODS: We conducted a cross-sectional study with 216 normal fetuses, between 20 and 34 weeks of gestation, 108 male and 108 female. Ventricular ...
Phoon Colin K L - - 2012
Barth syndrome is a rare, multisystem disorder caused by mutations in tafazzin that lead to cardiolipin deficiency and mitochondrial abnormalities. Patients most commonly develop an early-onset cardiomyopathy in infancy or fetal life. Knockdown of tafazzin (TAZKD) in a mouse model was induced from the start of gestation via a doxycycline-inducible ...
Lee Lik Chuan LC Departments of Surgery and Bioengineering, University of California, San Francisco, CA 94143, USA. - - 2011
Homogeneous contractility is usually assigned to the remote region, border zone (BZ), and the infarct in existing infarcted left ventricle (LV) mathematical models. Within the LV, the contractile function is therefore discontinuous. Here, we hypothesize that the BZ may in fact define a smooth linear transition in contractility between the ...
Sever Peter S - - 2011
AimsThe aim of this study was to determine the outcome benefits in those originally assigned atorvastatin in the Anglo-Scandinavian Cardiac Outcomes Trial-8 years after closure of the lipid-lowering arm (LLA) of the trial (ASCOT-LLA) among the UK population.Methods and resultsASCOT-LLA was a factorially designed double-blind placebo-controlled trial of atorvastatin in ...
Yamada Takumi - - 2011
A 55-year-old man underwent catheter ablation of ventricular tachycardia (VT) after anterior myocardial infarction. Although electrophysiological study suggested that the VT originated from the septum, biventricular endocardial irrigated radiofrequency ablation failed to interrupt the VT. Epicardial ablation at the site located halfway between the lesions in the right and left ...
Tang W H Wilson WH Center for Cardiovascular Diagnostics and Prevention, Department of Cell Biology, Lerner Research Institute, the Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA. - - 2011
Diminished serum arylesterase activity, catalyzed by the high-density lipoprotein-associated paraoxonase-1, is associated with heightened systemic oxidative stress and atherosclerosis risk. In the present study, we sought to determine the prognostic role of serum arylesterase activity in subjects with systolic heart failure, particularly in relation to established cardiac biomarkers. We measured ...
Ueeda Masayuki - - 2011
We studied the association of serum levels of arachidonic acid (AA) and eicosapentaenoic acid (EPA) with the prevalence of major adverse cardiac events (MACE) after acute myocardial infarction (AMI). We measured serum AA and EPA on admission in 146 consecutive AMI patients. The primary clinical endpoint was occurrence of MACE, ...
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