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Bangalore Sripal S From the Department of Medicine, Division of Cardiology, New York University School of Medicine (S.B.); Department of Biostatistics and Bioinformatics, Duke Clinical Research Institute, Durham, NC (M.J.P.); Department of Cardiology, The Methodist DeBakey Heart and Vascular Center, Houston, TX (N.S.K.); and Department of Cardiology, Saint-Luke's Mid America Heart Institute, University of Missouri-Kansas City School of Medicine - - 2014
The use of bivalirudin versus unfractionated heparin monotherapy in patients without ST-segment-elevation myocardial infarction is not well defined. The study population consisted of patients enrolled in the Evaluation of Drug-Eluting Stents and Ischemic Events (EVENT) registry with either non-ST-segment-elevation acute coronary syndromes or stable ischemic heart disease, who underwent percutaneous ...
Nomura Tetsuya - - 2014
Although several etiopathogenetic mechanisms have been proposed, the causes of left ventricular apical ballooning syndrome are still controversial. A 51-year-old Japanese woman consulted the emergency room complaining of the sudden onset of anterior chest pain while shopping. We initially suspected her disease as left ventricular apical ballooning syndrome based on ...
Bassand Jean-Pierre JP Department of Cardiology, EA3920, University Hospital Jean Minjoz, Besançon, - - 2014
Despite widespread adoption of acetylsalicylic acid and P2Y12 receptor inhibitor therapy as the standard of care for secondary event prevention in patients with acute coronary syndrome (ACS), the rate of cardiovascular death or myocardial infarction following discharge is approximately 24-31% over five years, indicating an important unmet need to reduce ...
Parks Natalie E NE Division of Neurology, Department of Medicine, Dalhousie University, - - 2014
Migrainous infarction accounts for 12.8% of ischemic strokes of unusual etiology. A 59-year-old woman with longstanding migraine with aura experienced what appeared to be migrainous infarction characterized by dysmetropsia and transient Cotard's syndrome. Imaging demonstrated right temporal-parietal-occipital changes with apparent cortical laminar necrosis. The spectrum of the pathophysiology of migrainous ...
Refaat Marwan M Marwan Refaat, Mostafa Hotait, Brion Winston, Department of Cardiology, American University Medical Center, Beirut 110 72020, - - 2014
Ehlers-Danlos syndrome (EDS) is a group of inherited connective tissue disorders caused by collagen synthesis defects. Several hemostatic abnormalities have been described in EDS patients that increase the bleeding tendencies of these patients. This case report illustrates a patient with an unusual presentation of a patient with type IV EDS, ...
Davis Mary E ME *Division of Cardiovascular Medicine (Davis, Haglund, and Keebler), †Department of Cardiac Surgery (Tricarico and Maltais), Vanderbilt University Medical Center, Nashville, TN - - 2014
Percutaneous continuous-flow (CF) micro axial blood pumps, like the Impella 5.0, are commonly used for short-term (ST) mechanical circulatory support in patients with acute decompensated heart failure (1). The Impella device often serves as a bridge to implantation of a long-term (LT) CF left ventricular assist device (CF-LVAD), such as ...
Steigen Sonja E - - 2014
Abstract Objectives: Patients previously treated with coronary stents may suffer an acute coronary syndrome (ACS) without any evidence of thrombus formation on coronary angiography (CAG). This may be due to partial, non-occlusive stent thrombosis with microembolization. In this paper we illustrate possible mechanisms both with Optical coherence tomography (OCT) and ...
Tülümen Erol E University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany; DZHK (German Centre for Cardiovascular Research) partner site Mannheim, Germany; Dr. Tülümen and Dr. Giustetto equally contributed to this manuscript.. Electronic address: - - 2014
Patients with a short QT syndrome (SQTS) have an increased risk for atrial, ventricular tachyarrhythmias and/or sudden cardiac death. PQ segment depression (PQD) is related to atrial fibrillation and carries a poor prognosis in the setting of acute inferior myocardial infarction and is a well defined ECG marker of acute ...
Taglieri Nevio N From the *Istituto di Cardiologia, Dipartimento di Medicina Specialistica Diagnostica e Sperimentale Azienda Ospedaliero-Universitaria di Bologna, Policlinico S.Orsola-Malpighi, Bologna, Italy, †Medicina Nucleare, Dipartimento di Medicina Specialistica Diagnostica e Sperimentale Azienda Ospedaliero-Universitaria di Bologna, Policlinico S.Orsola-Malpighi, Bologna, Italy, and ‡Radiologia, Dipartimentodi Medicina Specialistica Diagnostica e Sperimentale Azienda Ospedaliero-Universitaria di Bologna, Policlinico S.Orsola-Malpighi, Bologna, - - 2014
Patients with non-ST-segment elevation myocardial infarction (NSTEMI) represent a heterogeneous group in terms of jeopardized myocardium, pathogenetic mechanisms, and risk of recurrent events. In particular, estimation of myocardium at risk may be challenging before angiography. Yet the mechanisms leading to coronary instability underlying acute coronary syndromes (ACS) have not been ...
Moscarelli Marco M Department of Surgery and Cancer, Imperial College London, London, - - 2014
Although the European Society of Cardiology and AHA/ACC guidelines provide some suggestions regarding coronary artery bypass grafting (CABG) in the acute coronary syndrome (ACS), the exact indications for surgery in this diverse spectrum of disease requires further clarification. ACS may present with different scenarios, from NSTEMI to cardiogenic shock. Primary ...
Biglino Giovanni G Centre for Cardiovascular Imaging, UCL Institute of Cardiovascular Science, University College London, and Cardiorespiratory Division, Great Ormond Street Hospital for Children, National Health Service Foundation Trust, London, United Kingdom. Electronic address: - - 2014
To assess the coupling efficiency in hypoplastic left heart syndrome, considering the effect of surgical arch reconstruction and the shunt type received during the Norwood procedure. Ventriculoarterial coupling was assessed before Fontan completion in 32 patients with hypoplastic left heart syndrome (19 modified Blalock-Taussig and 13 Sano shunts at stage ...
Kunadian Vijay V Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University and Cardiothoracic Centre, Freeman Hospital, Newcastle Upon Tyne Hospitals NHS Foundation Trust, United - - 2014
Early administration of glycoprotein IIbIIIa inhibitors results in improved angiographic parameters, including thrombolysis in myocardial infarction (TIMI) flow grade, corrected TIMI frame count, and TIMI myocardial perfusion grade (TMPG) among patients with ST-segment elevation myocardial infarction. Whether the same is true in the setting of non-ST-segment elevation acute coronary syndrome ...
Noonan P M E - - 2014
Mortality outcomes associated with surgical palliation for hypoplastic left heart syndrome have continued to improve with time. Despite these advances, inter-stage mortality continues to be difficult to predict and prevent. This case report details a three year old boy with hypoplastic left heart syndrome palliated with a Glenn shunt who ...
Jang Ji Hun JH Division of Cardiology, Department of Internal Medicine, Inha University School of Medicine, Incheon, - - 2014
Spontaneous coronary artery dissection is a rare cause of acute coronary syndrome and sudden cardiac death. The incidence, causes, pathogenesis, and treatment have not been defined clearly, but spontaneous coronary artery dissection should be considered in young patients without major cardiovascular risk factors or in patients in the peripartum period ...
Desmet Walter W University Hospitals Leuven, Leuven, - - 2013
Even after coronary angiography, transient left ventricular ballooning syndrome (TLVBS) can be misdiagnosed as ST-elevation myocardial infarction (STEMI) caused by transient thrombotic occlusion of the left anterior descending artery, as the appearance of the left ventricular angiograms is often very similar. As prognosis and antithrombotic treatment of these two conditions ...
Ice Daniel S DS Division of Cardiovascular Diseases, Lankenau Medical Center and Lankenau Institute of Medical Research, Wynnewood, Jefferson Medical College, Philadelphia, Pennsylvania. Electronic address: - - 2014
The best regimen for the long-term management of patients with atrial fibrillation who present with an acute coronary syndrome or require placement of a coronary stent remains unclear. Clinicians need to understand the risk of stroke, stent thrombosis, and major bleeding associated with treating these patients. Numerous studies and risk ...
Fitchett David - - 2013
Atrial fibrillation in patients with acute coronary syndrome (ACS) is associated with a high thromboembolic event rate. Combined oral anticoagulant (OAC) and antiplatelet therapy (APT) are often used to reduce thromboembolic risk, recurrent coronary ischemic events, and stent thrombosis, despite the high bleeding risk. This review is timely with the ...
Mlakar Polona - - 2013
Abstract Background: High-sensitivity C-reactive protein (hsCRP) is an important biomarker of risk for coronary heart disease morbidity and mortality. We investigated the influence of short-term cardiac rehabilitation (CR) after acute myocardial infarction (AMI) on values of hsCRP and classical risk factors, including metabolic syndrome. Methods: hsCRP and classical risk factors ...
Michaud Katarzyna K University Center of Legal Medicine, Lausanne-Geneva, Rue du Bugnon 21, 1011 Lausanne, Switzerland. Electronic address: - - 2014
Cocaine is a well known trigger of acute coronary syndromes. Over the last 10 years levamisole, a veterinary anthelminthic drug has been increasingly used as an adulterant of cocaine. Levamisole was used to treat pediatric nephritic syndrome and rheumatoid arthritis before being withdrawn from the market due to its significant ...
Sacher Frederic F Bordeaux University Hospital, F-33000 Bordeaux, France; Univ. Bordeaux, L'Institut de RYthmologie et de modelisation Cardiaque, Centre de recherche Cardio-Thoracique de Bordeaux, U1045, F-33000, Bordeaux, France. Electronic address: - - 2013
We present the case of a 14-year-old female with early repolarization syndrome who presented with recurrent ventricular fibrillation and ICD shocks which were refractory to multiple drugs and catheter ablation. Treatment with quinidine, an Ito blocker, resulted in a normalization of J waves and suppression of VF. Interestingly, J wave ...
Chudek Jerzy J Department of Pathophysiology, Medical University of Silesia, Katowice, - - 2014
Double antiplatelet therapy with clopidogrel and acetylsalicylic acid is a standard procedure after acute coronary syndrome. This treatment carries a higher risk of complications. The main goal of this research was to assess the patients' quality of life after undergoing antiplatelet therapy with clopidogrel after acute coronary syndrome (ACS). In ...
Aykan Ahmet Cağrı - - 2013
The aim of the present study was to assess the association between metabolic syndrome (MS) and coronary artery disease (CAD) complexity assessed by SYNTAX score (SS) and severity in non-diabetic patients with stable CAD whom underwent coronary angiography and to evaluate whether the MS defined by different definitions including International ...
Davidson Laura L Northwestern University Feinberg School of Medicine, Chicago, Ill. Electronic address: - - 2013
Acute coronary syndrome due to acute plaque rupture has been well described and is associated with established risk factors, including hypertension, diabetes mellitus, hyperlipidemia, and smoking. The prevalence of these risk factors in very young patients (aged ≤35 years) is not well known, and they may have other nontraditional risk ...
Chang Kuai-Le KL Department of Cardiology, 3rd Hospital of the Chinese People's Liberation Army, 45 Dongfeng Road, Baoji, Shaanxi Province, - - 2013
Kounis syndrome has been defined as an acute coronary syndrome that manifests as unstable vasospastic or nonvasospastic angina, and even as acute myocardial infarction. It is triggered by the release of inflammatory mediators following an allergic insult or patient ill health, drug intake or environmental exposure. We report on a ...
Giday Araya - - 2013
Evidence based clinical guidelines have provided clinicians with an increasing tool for management of hospitalized patients. However, large differences in the management of patients with acute coronary syndrome observed across the globe. To determine spectrum of severity, practice patterns and half-year outcomes of patients hospitalized with acute coronary syndrome in ...
Brenes Salazar Jorge A JA Department of Medicine, Division of Cardiovascular Diseases, Mayo Clinic, MN, - - 2013
Transient apical cardiomyopathy, also known as Takot-tsubo-like left ventricular dysfunction, is a clinical syndrome characterized by reversible left ventricular dysfunction at the apex with preserved basal contractility, in the setting of new ST and T wave changes suggestive of ischemia but no evidence of obstructive coronary artery disease on angiography. ...
Lim Joanna - - 2013
An 81 year old female patient diagnosed with a chronic low grade hypereosinophilic syndrome presented with angina and dyspnoea. She was managed for a non-ST elevated myocardial infarction since her troponin levels were elevated. On day 5, she suffered an acute clinical deterioration with type I respiratory failure and cardiogenic ...
Makki Nader - - 2013
Acute coronary syndrome (ACS) is a major health care and economic burden in the United States and accounts for more than 1 million hospitalizations annually. The morbidity and mortality due to ACS are substantial-nearly half of all deaths due to coronary heart disease occur following an ACS. This review provides ...
Andò Giuseppe G Department of Clinical and Experimental Medicine, Section of Cardiology, University of Messina, - - 2013
Apical ballooning syndrome or Takotsubo-like cardiomyopathy is an acute syndrome characterized by normal or near-normal coronary arteries, regional wall motion abnormalities that extend beyond a single coronary vascular bed and, often, a precipitating stressor. We observed a case of an elderly lady with Takotsubo-like left ventricular dysfunction in whom both ...
Que Bin - - 2013
Acute myocardial infarction complicated by cardiogenic shock and left main coronary artery disease is called left main shock syndrome. It is reported that the morbility and mortality of the syndrome is approximately 0.46% and 55%-80%, respectively. However, the best treatment strategy in these cases is unknown. In this article, we ...
Udroiu Cristian A CA University and Emergency Hospital of Bucharest, Department of Cardiology, - - 2013
We reported a patient with Takotsubo syndrome, with severe symptoms, prolonged angina with hemodynamic compromise, in the context of severe coronary artery spasm, without response to full medical treatment, which was successfully managed with coronary balloon angioplasty. A 49-year old woman was admitted with chest pain, ECG changes and elevated ...
Alihanoglu Yusuf I - - 2013
The aim of this study is to evaluate heart rate recovery and association between coronary flow rate and heart rate recovery in patients with metabolic syndrome who had morphologically normal coronary angiogram. Study population included 43 patients with metabolic syndrome and 37 control subjects without metabolic syndrome. All patients were ...
Sharma Sanjiv - - 2013
The rationale for intracoronary administration of abciximab is discussed. The data on use of intracoronary abciximab in percutaneous coronary interventions in acute coronary syndromes and STEMI are reviewed. Evaluation of the niche where intracoronary administration of abciximab may be useful and future research into the subject are discussed.
Madias John E - - 2013
Takotsubo syndrome (TTS) is characterized by electrocardiogram (ECG) diffuse ST-segment elevations (+ST), and T-wave inversions with prolongation of the QTc interval. Thus ECG-wise, TTS is not different from acute coronary syndromes (ACSs). However unlike acute ST-elevation myocardial infarction, one type of ACS, a rapid conversion of+ST to T-wave inversion with ...
Spiliopoulos Sotirios - - 2013
We report the case of a 55 years old caucasian male patient with cardiogenic shock due to an extended myocardial infarction who underwent SynCardia Total Artificial Heart implantation and veno-venous extracorporeal membrane oxygenation with a bicaval dual-lumen cannula for the treatment of adult respiratory distress syndrome.
Szél Tamás - - 2013
Brugada syndrome is an inherited disease associated with vulnerability to ventricular tachycardia and sudden cardiac death in young adults. Milrinone and cilostazol, oral phosphodiesterase (PDE) type III inhibitors, have been shown to increase ICa and modestly increase heart rate by elevating the level of intracellular cyclic AMP. The present study ...
Burgess Sonya N - - 2013
Diabetes mellitus (DM) is a powerful independent risk factor for multivessel, diffuse coronary artery disease (CAD). The optimal coronary revascularization strategy in DM is not clearly defined, but past trials have suggested an advantage for coronary artery bypass grafting (CABG). Recently, the Future Revascularization Evaluation in Patients with Diabetes Mellitus: ...
Zanini Gregoriana - - 2013
The Kounis syndrome was first described in 1991 as'the allergic angina syndrome'which could progress to acute myocardial infarction which was named'allergic myocardial infarction. There are several causes underlying this syndrome including drugs, various conditions and a variety of environmental exposure factors such as animal stings. Hymenoptera stings can induce Kounis ...
Xu Zhaolong Z Cardiology Department, Medical College, Jinzhou, Liaoning Province, - - 2014
An 82-year-old female presented lasting chest pain for stimulation and the ECG revealed ventricular fibrillation and ST segment elevation, so we considered acute myocardial infarction. However, after the clinical condition of the patient improved, symptoms recurred for stimulation again on day 4. An echocardiogram showed left ventricular apical ballooning, so, ...
Ws Aronow - - 2013
Patients with unstable angina pectoris/non-ST-elevation myocardial infarction (NSTEMI) should be treated with dual antiplatelet therapy with the use of aspirin plus either clopidogrel, prasugrel, or ticagrelor depending on the clinical circumstances as discussed in this article. If ticagrelor is used, the dose of aspirin must not exceed 100 mg daily. ...
Mega Jessica L - - 2013
The dosing of anticoagulants is critical when balancing efficacy and safety. The Anti-Xa Therapy to Lower Cardiovascular Events in Addition to Aspirin With/Without Thienopyridine Therapy in Subjects With Acute Coronary Syndrome 2-Thrombolysis In Myocardial Infarction 51 (ATLAS ACS 2-TIMI 51) trial was designed to evaluate 2 low doses of rivaroxaban ...
Gorgels Anton P M - - 2013
The 12 lead surface electrocardiogram (ECG) is an indispensable tool to identify acute coronary syndromes and the patient at high risk. Acute coronary syndromes are classified according to the presence or absence of ST elevation (ST Elevation Myocardial Infarction or Acute Coronary Syndrome, STEMI or STEACS and Non ST Elevation ...
Bayram Nihal A - - 2013
In our study, we aimed to evaluate left ventricular function in patients with Sjögren syndrome (SS) using tissue Doppler echocardiography (TDE) and myocardial performance index (MPI) in addition to conventional echocardiographic methods. We evaluated 50 patients with SS and 48 healthy volunteers with similar demographic characteristics. Systolic and diastolic functions ...
Meier Pascal - - 2013
While outcomes for ST-segment-elevation myocardial infarction has significantly decreased over the last years, patients presenting with non-ST-segment-elevation acute coronary syndromes (NSTEACS) still have a rather high mortality. Longer term mortality over 4 years is about double the mortality after a ST-segment-elevation myocardial infarction. The reason for the poorer prognosis is unclear ...
Sezer Murat - - 2013
The extent of coronary microvascular dysfunction might be related, not only to patient characteristics and procedural factors, but also to the inflammatory status. The aim of the present study was to examine a possible association between inflammation, as reflected by the serum C-reactive protein (CRP) levels, and the extent of ...
Gukathasan Nilusha - - 2013
Contemporary management of acute coronary syndromes (ACS) has evolved to include rapid revascularization, potent antithrombotic, and antiplatelets, all of which reduce the risk of ischemic complications. Despite these advances, recurrent ischemic and bleeding event rates are still substantial. This increased risk post-percutaneous coronary intervention (PCI) has been the seminal event ...
Gautam M P MP Department of Cardiology, College of Medical Sciences, Bharatpur, - - 2013
Introduction: Acute coronary syndrome is the major leading cause for coronary care unit admission. Its spectrum comprises a variety of disorders including unstable angina, non ST elevation and ST elevation myocardial infarction. Its spectrum and incidence is crucial as a part of need assessment of cardiac catheterization laboratories. Methods: An ...
Maciel Bruno Araújo - - 2013
Takotsubo syndrome is characterized by predominantly medial-apical transient left ventricular dysfunction, which is typically triggered by physical or emotional stress. The present article reports the case of a 61-year-old female patient presenting with dizziness, excessive sweating, and sudden state of ill feeling following an episode involving intense emotional stress. The ...
Jaiswal Abhishek A Division of Cardiology, Department of Internal Medicine, New York Hospital Queens/Weill Medical College of Cornell University, New York, New - - 2013
Coronary spasm may present as acute coronary syndrome (ACS), "which can be an ST segment elevation myocardial infarction (STEMI), non-STEMI, or unstable angina." However, the prevalence of coronary spasm in patients with ACS remains unknown due to scarcity of data. Concomitant coronary spasm may mask the true atherosclerosis burden in ...
Klutstein Marc W - - 2013
Bleeding is a major limitation of antithrombotic therapy among invasively managed non-ST-segment elevation acute coronary syndromes (NSTE-ACS) patients; therefore, we examined the use of radial access and its association with outcomes among NSTE-ACS patients. Clinical characteristics and geographic variation in radial access were examined, as well as its association with ...
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