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Jablonowski Robert R Department of Radiology and Biomedical Imaging, School of Medicine, University of California San Francisco, 185 Berry St, Suite 350, Campus Box 0946, San Francisco, CA - - 2014
To measure and validate patchy and large myocardial infarction (MI) at 3 days and 5 weeks in beating and nonbeating hearts using contrast-enhanced three-dimensional (3D) inversion-recovery gradient echo (IR-GRE) magnetic resonance imaging (MRI) and microscopy. Pigs (n = 28) were subjected to 1) patchy MI (group I), 2) large MI (group II), or 3) ...
Sakamoto Ayami A 1 All authors: Department of Radiology, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, - - 2014
OBJECTIVE. The purpose of this study was to evaluate the usefulness of quantification of lung perfused blood volume (PBV) with dual-energy CT (DECT) for assessment of the severity of acute pulmonary thromboembolism (PTE). MATERIALS AND METHODS. We retrospectively analyzed the records of 72 patients with PTE and 168 without PTE ...
Basili Stefania S From the I Clinica Medica (S.B., V.R., P.P., R.C., F.V.), Department of the Heart and Great Vessels Attilio Reale (G.T., C.C., F.B., E.M.), and Department of Public Health and Infectious Diseases (A.F.), Sapienza-University of Rome, Rome, Italy; and Division of Cardiology, Department of Interventional Cardiology, Santa Maria University Hospital, Terni, Italy (M.D., A.P., A.A.). - - 2014
Microvascular obstruction seems to predict poor outcome in patients undergoing elective percutaneous coronary intervention (PCI), but the underlying mechanism is still unclear. We analyzed whether serum thromboxane B2, a stable metabolite of thromboxane A2, may be implicated in post-PCI microvascular obstruction. We enrolled 91 patients (74 males, 66±10 years) on ...
Jiang Changhao C Department of Cardiology, Yiwu Hospital of Wenzhou Medical University (Yiwu Central Hospital), Yiwu, 322000, Zhejiang, People's Republic of China, - - 2014
Our objective was to explore the effects of miR-92a and miR-126 on myocardial apoptosis in mouse ischemia-reperfusion model and further investigate the underlying mechanisms. Eighteen Kunming mice were selected and randomly divided into sham operation group and ischemia-reperfusion group with nine mice in each group. Cardiac muscle tissue was stained ...
Huang Zhi-Bin ZB Department of Cardiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, - - 2014
This study investigated the effects of fosinopril on the electrophysiological characteristics of the left ventricular hypertrophic myocardium in spontaneously hypertensive rats (SHRs). Twenty-four 10-week-old male SHRs were divided into fosinopril and non-fosinopril groups (n = 12 each). Twelve 10-week-old Wistar-Kyoto rats were used a control group. Left ventricular mass index and ventricular ...
Miyoshi Hirokazu H Cardiovascular Section, Higashi Tokushima Medical Center, National Hospital Organization , Tokushima , Japan - - 2014
Abstract Left atrial (LA) structural and functional abnormalities are vital steps on the pathway toward heart failure with preserved ejection fraction in asymptomatic patients. The purpose of this study was to assess the relationship of LA function, particularly reservoir function, with LA structural remodeling related to the left ventricular (LV) ...
Gamou Tadatsugu T Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8640, - - 2014
The occurrence of deteriorated coronary flow associated with distal embolization during percutaneous coronary intervention results in impaired myocardial perfusion and worsens the clinical prognosis. This study aimed to examine the impact of optical coherence tomography (OCT)-determined coronary plaque morphology on the prediction of deteriorated coronary flow after stent implantation in ...
Guo Chun-Yu CY Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, - - 2014
To explore the effects of Panax Quinquefolium Saponin (PQS) on phosphatidylinositol 3-kinase/serine threonine kinase (PI3K/Akt) pathway of neonatal rat myocardial cells subjected to hypoxia. Neonatal rat myocardial cells were cultured in vitro. After the myocardial cell injury was induced by hypoxia, the cells were randomized into 5 groups: the normal ...
Kongoji Ken K Division of Cardiology, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, Kanagawa, 216-8511, - - 2014
We evaluated the influence of early defects (EDs) in the infarcted myocardium after reperfusion, detected by computed tomography angiography (CTA), on cardiac function and exercise capacity in the chronic phase. We retrospectively analyzed 48 acute myocardial infarction (AMI) patients who underwent both CTA using 64-slice multidetector CT within 14 ± 6 days and ...
Song Pil Sang PS Division of Cardiology, Department of Internal Medicine, Inje University Haeundae Paik Hospital, Busan, Corea del - - 2014
It is uncertain whether side branch predilatation before main vessel stenting is necessary. We evaluated the effect of side branch predilatation on outcomes in percutaneous coronary intervention for true nonleft main bifurcation determined by the Medina classification using the provisional approach. Target vessel failures (composite of cardiac death, myocardial infarction, ...
Niazi Imran I Aurora Cardiovascular Services, Aurora Sinai/Aurora St. Luke's Medical Centers, University of Wisconsin School of Medicine and Public Health, 2801 W. Kinnickinnic River Parkway, #840, Milwaukee, 53215, WI, USA, - - 2014
Left ventricular (LV) electrical activation pattern could determine optimal LV lead placement site during cardiac resynchronization therapy (CRT) device implant. We sought to determine the feasibility of using EnSite NavX™ electroanatomic mapping system (St. Jude Medical Inc., St. Paul, MN) to assess LV electrical activation during CRT implant. Patients (n = 32; ...
Yang Li L Department of Cardiology, Sun Yat-Sen Memorial Hospital, Sun Yet-Sen University, 107 Yanjiang West Road, Guangzhou, 510120, China, - - 2014
To study left atrial deformation characteristics using Velocity vector imaging (VVI) in hypertensive patients with and without left ventricular hypertrophy (LVH), and to explore its value for detection of left atrial dysfunction in these patients. Sixty-four patients with essential hypertension were divided into normal left ventricular geometry (LVN, 37 cases) ...
Gruzdeva Olga - - 2014
Free fatty acids (FFA), oxidized low-density lipoprotein (LDL) and its antibodies, lipid profile markers, which are formed under oxidative stress, play an important role in atherosclerotic disease. Assess the levels of these markers in myocardial infarction patients depending on the extent of coronary artery disease (CAD). ST-elevation MI patients with ...
Ma Kai K Pediatric Cardiac Surgery Center, National Center for Cardiovascular Disease and Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, - - 2014
To determine outcomes of patients presenting with an anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) who underwent coronary transfer, and to investigate the role of the left ventricular ejection fraction (LVEF) and preoperative myocardial viability as the predictors for incomplete LV functional recovery. From 2002 ...
Akgul Ozgur O Department of Cardiology, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Center, Training and Research Hospital, Istanbul, - - 2014
The aim of this study was to evaluate the prognostic value of fragmented QRS (fQRS) on electrocardiography (ECG) patients with acute ST-segment elevation in myocardial infarction (STEMI), who are undergoing primary percutaneous coronary intervention (PCI). We prospectively enrolled 414 consecutive STEMI patients (mean age of 55.2 ± 12.2 years old, ...
Yarbrough William M WM Sisters of Charity Providence - - 2014
Historically, the tissue inhibitors of matrix metalloproteinases were considered monochromatic in function. However, differential TIMP profiles more recently observed with left ventricular dysfunction and matrix remodeling suggest more diverse biological roles for individual TIMPs. This study tested the hypothesis that cardiac specific overexpression (TIMP-4OE) or deletion (knockout; TIMP-4KO) would differentially ...
Qian Yuanyu Y Department of Emergency, Chinese PLA General Hospital, Beijing 100853, P.R. - - 2014
In the present study, the effect of initial body temperature changes on myocardial enzyme levels and cardiac function in acute myocardial infarction (AMI) patients was investigated. A total of 315 AMI patients were enrolled and the mean temperature was calculated based on their body temperature within 24 h of admission ...
Lu Xiao-Mei XM Department of Pathophysiology, College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning 110001, P.R. - - 2014
The aim of the present study was to investigate the effect of olmesartan medoxomil (OLM) on renal injury in mice with myocardial infarction (MI). A total of 33 male C57/BL/6 mice were divided into a sham surgery group (SHAM group), MI group (MI group) and OLM treatment group (OLM group). ...
Cheng Rongchao R Department of Cardiology, The Fourth Affiliated Hospital of Harbin Medical University, Heilongjiang Province, - - 2014
Coronary flow reserve (CFR) in the non-infarcted myocardium is often impaired following acute myocardial infarction (AMI). However, the clinical significance of CFR in the non-infarcted myocardium is not fully understood. The objective of the present study was to assess whether a relationship exists between CFR and left ventricular remodeling following ...
Yang Fengyong F ICU, Affiliated Hospital of Qingdao University, 21 Jiangsu Road, Qingdao, 266000, - - 2014
The aim of the study was to evaluate the clinical efficacy of hydrogen sulfide (H2S) treatment on the endothelin-induced cardiac hypertrophy. Sixty-four adult male rats, weighing from 180 to 200 g, were randomly divided into four groups: ten in normal group, ten in sham group, 44 in model group established by ...
Liu Q Q Department of Emergency Medicine, People's Hospital of Zhengzhou, Zhengzhou, Henan Province, China. - - 2014
To explore the heart protection effects by RNA interference of Caspase-3 on rat acute myocardial infarction (AMI). 45 SD rats were randomly divided into sham group, AMI group and Caspase-3-siRNA group. Animal model of AMI was established by ligation of anterior descending branch (LAD). Rats of sham operation group and ...
Choi Yun Ha YH 0000-0002-0224-0062 The Division of Cardiology, Chonnam National University Hospital, Gwangju, Korea. ; College of Nursing, Chonnam National University, Gwangju, - - 2014
The aim of this study was to evaluate the relation between neutrophil-to-lymphocyte ratio (NLR) and plaque components assessed by virtual histology-intravascular ultrasound in 399 coronary artery disease (CAD) patients with 471 coronary lesions. We classified the lesions into two groups according to the NLR on admission {low NLR group (NLR≤2.73 ...
Wang Xiang X Department of Cardiology, Shanghai First People's Hospital, Affiliated Shanghai Jiaotong University, Shanghai, 200080, - - 2014
The efficacy of post-percutaneous coronary intervention (PCI) intracoronary injection with bone marrow mesenchymal stem cells (BMSCs) in patients with acute myocardial infarction (AMI) remains controversial. Here, 58 patients with AMI undergoing PCI were randomly divided into two groups: BMSC and control groups. Autologous BSMCs were then generated in vitro from ...
Di Mauro Michele M Department of Adult Cardiac Surgery, Prince Sultan Cardiac Center, Riyadh, Kingdom of Saudi Arabia Department of Cardiology, University of L'Aquila, L'Aquila, - - 2014
The aim of this study was to evaluate 17-year actual clinical outcomes of patients undergoing coronary artery bypass graft (CABG) using skeletonized versus pedicled bilateral internal mammary arteries (BIMAs). From September 1991 to June 1996, 548 consecutive patients underwent CABG for multivessel disease using BIMA. After propensity matching, 350 patients ...
Cetin Mustafa M aDepartment of Cardiology, School of Medicine, Adiyaman University, Adiyaman bDepartment of Cardiology, Kahramanmaras State Hospital, Kahramanmaras, - - 2014
Coronary collaterals may be insufficient for restoring blood flow to normal levels in patients with chronic total occlusions (CTO), leading to myocardial ischemia and electrical inhomogeneity in the ventricles. We evaluated the effect of percutaneous CTO revascularization on parameters of ventricular repolarization, including the T wave peak-to-end interval (TpTe) interval, ...
Kim Kyung Hwan KH Division of Cardiology, Department of Internal Medicine, Gwangju Veterans Hospital, Gwangju, Republic of - - 2014
The CHA2DS2VASc score has been used to evaluate the risk of thromboembolic events in atrial fibrillation. However, because all the components of CHA2DS2VASc are important cardiovascular risk factors, we decided to evaluate the effectiveness of CHA2DS2VASc score as a long-term predictor for prognosis in acute myocardial infarction (AMI) patients. We ...
Zhang She-Qing SQ Department of Neurology, Changhai Hospital, Second Military Medical University, Shanghai, - - 2014
Anticoagulants are commonly used to treat ischemic stroke. Its impact on cerebellar infarction has not been fully understood. In the clinical study, we reviewed a consecutive series of patients with large-sized cerebellar infarction (diameter > 3 cm, n = 30) treated with or without anticoagulation. In animal study, cerebellar infarction operation was performed in 12 ...
Liao Kai K Department of Cardiology, Renmin Hospital of Wuhan University and Cardiovascular Research Institute of Wuhan University, P.R. - - 2014
: Electrical carotid baroreceptor stimulation (CBS) has shown therapeutic potential for resistant hypertension and heart failure by resetting autonomic nervous system, but the impacts on arrhythmias remains unclear. The present study evaluated the effects of CBS on ventricular electrophysiological properties in normal dog heart and arrhythmias following acute myocardial infarction ...
Watabe Taichi T The Second Department of Internal - - 2014
Unnecessary ventricular pacing in sinus node disease (SND) must be avoided. To test the hypothesis that in SND, with or without 1(st) degree atrioventricular (AV) block, cumulative percent ventricular pacing (cum%VP) can be limited by low right atrial septal (LRAS) instead of right atrial appendage (RAA) pacing. We studied 102 ...
Joukar Siyavash S Physiology Research Center, School of Medicine, Kerman University of Medical Sciences, Kerman, - - 2014
Objective: We aimed to assess the influence of Melissa officinalis (lemon balm), a well-known herbal drug with numerous applications in traditional and modern medicine, on cardiac conduction and susceptibility to lethal ventricular arrhythmia. Materials and Methods: Forty-two male Wistar rats were divided into a control group (CTL), an M. officinalis ...
Bai Min-Fu MF Department of Cardiology, Zhengzhou University People's Hospital, Zhengzhou, - - 2014
Abnormal thyroid hormone metabolism influences the occurrence and progress of coronary heart disease (CHD). The aim of the present study was to analyze the severity of coronary artery lesions and the prognosis of thyroid dysfunction patients admitted for coronary angiography (CAG). From July 2011 to July 2012, 605 consecutive patients ...
Ding X X Department of Cardiology, Changhai Hospital, 2nd Military Medical University, 168 Changhai Road, 200433, Shanghai, PR - - 2014
The aim of this study was to investigate whether renal sympathetic denervation (RSD) is more effective on myocardial hypertrophy than the angiotensin-converting enzyme inhibitor (ACEI) perindopril in spontaneously hypertensive rats (SHRs). After bilateral renal denervation blood pressure (BP) was measured every 10 days. On day 50 the heart was (histo)pathologically examined. ...
Newby L Kristin LK Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA. Electronic address: - - 2014
p38 MAPK inhibition has potential myocardial protective effects. We assessed losmapimod, a potent oral p38 MAPK inhibitor, in patients with non-ST-segment elevation myocardial infarction (NSTEMI) in a double-blind, randomised, placebo-controlled trial. From October, 2009, to November, 2011, NSTEMI patients were assigned oral losmapimod (7·5 mg or 15·0 mg loading dose ...
Sohn Gwan Hyeop GH Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of - - 2014
Although obesity is a risk factor for cardiovascular disease and mortality, several studies have reported that patients with obesity who have suffered acute myocardial infarction or have undergone percutaneous coronary intervention (PCI) have better clinical outcomes than their normal weight counterparts. We evaluated the impact of overweight on myocardial infarct ...
Tassi Eduardo Marinho EM Instituto de Cardiologia Edson Saad, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, - - 2014
Background: Patients with Chagas disease and segmental wall motion abnormality (SWMA) have worse prognosis independent of left ventricular ejection fraction (LVEF). Cardiac magnetic resonance (CMR) is currently the best method to detect SWMA and to assess fibrosis. Objective: To quantify fibrosis by using late gadolinium enhancement CMR in patients with ...
Katz Michael G MG Sanger Heart and Vascular Institute, Cannon Research Center, Carolinas Healthcare System, Charlotte, - - 2014
Therapeutic safety and efficacy are the basic prerequisites for clinical gene therapy. We investigated the effect of high-dose molecular cardiac surgery with recirculating delivery (MCARD)-mediated adeno-associated virus 9 (AAV9)/sarcoplasmic reticulum Ca(2+) adenosine triphosphatase (SERCA2a) gene delivery on clinical parameters, oxidative stress, humoral and cellular immune responses, and cardiac remodeling. Ischemic ...
Hong Soon Jun SJ Krannert Institute of Cardiology; Indiana Center for Vascular Biology and Medicine; Indiana University School of Medicine, Indianapolis; R.L. Roudebush Veterans Affairs Medical Center, Indianapolis, IN; Korea University Anam Hospital, Seoul, - - 2014
Objectives: The potential for beneficial effects of adipose-derived stem cells(ASCs) on myocardial perfusion and left ventricular dysfunction in myocardial ischemia(MI) has not been tested following intravenous delivery. Methods: Surviving pigs following induction of MI were randomly assigned to 1 of 3 different groups: the placebo group (n=7), the single bolus ...
Hong Sung-Jin SJ Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, - - 2014
Despite the usefulness of intravascular ultrasound (IVUS) in percutaneous coronary intervention (PCI), the impact of IVUS guidance on clinical outcomes, particularly for chronic total occlusion (CTO) intervention, has rarely been studied. We sought to investigate the clinical usefulness of IVUS-guided CTO intervention with second-generation drug-eluting stent implantation. From 2007 to ...
Koltowski Lukasz L 1st Department of Cardiology, Medical University of Warsaw, Warsaw, - - 2014
Numerous studies have compared transradial (TR) versus transfemoral (TF) access for percutaneous coronary intervention (PCI) in patients with acute ST-segment elevation myocardial infarction. These studies have focused on clinical efficacy and safety; yet little is known about the effect of the vessel access on the health-related quality of life (HRQoL). ...
Hu Zeng-Chun ZC 1Department of Neurosurgery, the Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116044, - - 2014
Abstract Purpose: Motor impairment is an important index for assessing the extent of brain injury. The present study uses a new method, the movement capture analysis (MOCA) system, for assessing motor damage after acute ischemia. Materials and Methods: Forty rats were divided into four groups: standard ischemia, sham-operated, Dizocilpine (MK-801) ...
Wu Xiao-Yan XY Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, P.R. - - 2014
The roles of oxidative stress on nuclear factor (NF)‑κB activity and cardiomyocyte apoptosis during heart failure were examined using the antioxidant N‑acetylcysteine (NAC). Heart failure was established in Japanese white rabbits with intravenous injections of doxorubicin, with ten rabbits serving as a control group. Of the rabbits with heart failure, ...
Cao Jun-Xian JX Department of Cardiology, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China; Department of Chinese Medicine, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, - - 2014
Objective: To investigate stretch-induced electrophysiological changes in chronically infarcted hearts and the effect of streptomycin (SM) on these changes in vivo. Methods: Sixty Wistar rats were divided randomly into four groups: a control group (n=15), an SM group (n=15), a myocardial infarction (MI) group (n=15), and an MI+SM group (n=15). ...
Brant S M SM Department of Cardiovascular and Thoracic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address: - - 2014
Most studies investigating machine perfusion preservation for heart transplantation perfuse through the aortic root (antegrade), but the coronary sinus (retrograde) is a potential option. We hypothesized that retrograde machine perfusion provides better functional protection than static storage, while avoiding the potential irregular perfusion seen when aortic insufficiency occurs with antegrade ...
Ribeiro Demóstenes G L DG Department of Clinical Medicine, Faculty of Medicine, Federal University of Ceará, Fortaleza, CE, - - 2014
This study aimed to investigate the clinical correlation between angiographic coronary atherosclerosis and N-terminal pro-B-type natriuretic peptide along with other known correlated factors. In total, 153 patients with a diagnostic hypothesis of stable angina, unstable angina or acute myocardial infarction were classified as group A (patients with angiographically normal coronary ...
Liu Peng P Cardiovascular center, China-Japan Friendship Hospital, Beijing 100029, - - 2014
The aim of this retrospective observational study was to investigate the effect of on-pump versus off-pump coronary artery bypass grafting (CABG) for patients with coronary artery diseases (CAD). A retrospective observational study was performed using a propensity score analysis in 290 consecutive patients undergoing CABG between April 2009 and March ...
Ma Yuxuan - - 2014
To observe the impact of total flavonoids from Ganshanbian (Herba Hyperici Attenuati) on the expression of vascular smooth muscle membrane L-type calcium channel alpha1 C subunit (CaL-alpha1C) and ATP-sensitive K+ channel (K(ATP))-Kir6.1 mRNA, and explore the mechanisms of the antiarrhythmic effect of Ganshanbian (Herba Hyperici Attenuati) total flavonoids. The treatment ...
Lee Chan-Hee CH Department of Cardiology, Yeungnam University Hospital, 170, Hyeonchung-ro, Nam-gu, Daegu, 705-717, South - - 2014
The benefit of statin use after acute ST-segment elevation myocardial infarction (STEMI) has been well established, however, the influence of the timing of statin administration has not been elucidated. The objective of this study focused on early clinical outcomes after percutaneous coronary intervention (PCI). This analysis of the Korea Working ...
Sunman Hamza H Department of Cardiology, Ministry of Health Dışkapı Yıldırım Beyazıt Education and Research Hospital, 06110, Ankara, - - 2014
Multidetector computed tomography (MDCT) coronary angiography represents one of the most exciting technological revolutions in cardiac imaging and it has been increasingly used in the diagnosis of coronary artery disease. The purpose of this study is to investigate the effect of age and coronary plaque calcification on diagnostic accuracy of ...
Brembilla-Perrot Béatrice - - 2014
Programmed ventricular stimulation (PVS) is a technique for screening patients at risk for ventricular tachycardia (VT) after myocardial infarction (MI), but the results might be difficult to interpret. To investigate the results of PVS after MI, according to date of completion. PVS results were interpreted according to the mode of ...
Seferovic Jelena P - - 2014
Abstract Background: Galectin-3 is a protein widely distributed in the heart, brain and blood vessels, and has a regulatory role in inflammation, immunology and cancer. Many studies demonstrated that the increased level of galectin-3 is associated with progressive fibrosis and stiffening of the myocardium. The aim of this study was ...
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