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Results 151 - 200 of 1902
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Berry Colin - - 2013
In patients with acute non-ST-elevation myocardial infarction (NSTEMI), coronary arteriography is usually recommended; but visual interpretation of the angiogram is subjective. We hypothesized that functional assessment of coronary stenosis severity with a pressure-sensitive guide wire (fractional flow reserve [FFR]) would have additive diagnostic, clinical, and health economic utility as compared ...
Feng Chao - - 2013
Objective Our study focused on acute lacunar infarct shapes to explore the risk factors and clinical significance of irregularly shaped lacunar infarctions. Methods Based on the shape of their acute lacunar infarct, patients (n=204) were classified into the "regular" group or "irregular" group. The characteristics of the lacunar infarction were ...
Hadadzadeh Mehdi M Department of Cardiovascular Surgery, Afshar Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. - - 2013
Myocardial dysfunction is a major complication in cardiac surgery that needs inotropic support. This study evaluates the effect of milrinone on patients with low ventricular ejection fraction undergoing off- pump coronary artery bypass graft (OPCAB). The present study is designed to evaluate the effect of milrinone on myocardial dysfunction. Eighty ...
Radulescu D D University of Medicine and Pharmacy "Iuliu Hatieganu", 5th Medical Hospital, Department of Cardiology, Cluj-Napoca, - - 2013
Purpose: The aim of this study was to assess whether treatment with angiotensin converting enzyme inhibitors (ACEI) can prevent the alteration of left ventricular systolic and diastolic performance in cancer patients treated with different chemotherapy regimens containing epirubicin. Methods: In this prospective study , 68 patients with different malignant tumors ...
Kim Kyung Hwan KH Division of Cardiology, Department of Internal Medicine, Gwangju Veterans Hospital, Gwangju, - - 2013
The high-sensitivity C-reactive protein (hs-CRP), a marker of inflammation, has been known to be elevated in patients with coronary artery disease. However, there is controversy about the predictive value of hs-CRP after acute myocardial infarction (MI). Therefore, we evaluated the impact of ischemic time on the predictive value of hs-CRP ...
Yoon Namsik N Department of Cardiology, Chonnam National University Hospital, Gwangju, - - 2013
It is widely known that angiotensin-II receptor blockers (ARBs) have reverse remodeling effects in atrium. Although atrial fibrillation is frequent in ischemic heart failure clinically, experiments to demonstrate ARB's effects on atrial remodeling in a heart failure model are rare. A heart failure model and a sham-operated group were formed ...
Al-Amran Fadhil G FG MD FRCS FACS, Surgical Department, Medical College, Kufa University, Najaf, - - 2013
To investigate the effects of two different sets of graft temperature during perfusion on myocardial protection in the immediate post transplantation period in rats. RATS GROUPED INTO: Sham and two study groups, which include two set groups of heterotopic heart transplant perfused at two different temperature set. The studied groups ...
Salgado Filho Marcello Fonseca - - 2013
To evaluate the rates of mortality and morbidity in patients undergoing coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB) using routine intraoperative transesophageal echocardiography (ITEE). We conducted a retrospective, observational review of medical records of 360 patients from April 2010 to April 2012. We analyzed: age, weight, height, gender, ...
Zhang Mei-Qi - - 2013
Aim:To investigate the mechanisms underlying the protective effects of sodium tanshinone IIA sulfonate (STS) in an ischemia-reperfusion (I/R)-induced rat myocardial injury model.Methods:Male SD rats were iv injected with STS, STS+LY294002 or saline (NS) for 15 d. Then the hearts were subjected to 30 min of global ischemia followed by 2 ...
Wang Yang - - 2013
Methods One hundred and thirty-three patients with essential hypertension were divided into four groups according to criteria proposed by Ganau et al: 36 patients in normal pattern group (I), 34 patients in concentric remodelling pattern group (II), 33 patients in concentric hypertrophy pattern group (III), and 30 patients in eccentric ...
Saeed Maythem - - 2013
To use multi-detector computed tomography (MDCT) for assessing the effects of coronary microemboli on pre-existing acute myocardial infarct (AMI) and to compare this pathology to LAD microembolization and occlusion/reperfusion. An angioplasty balloon catheter was placed in the LAD coronary artery of pigs under X-ray guidance. Four animals served as controls ...
Hahn Joo-Yong - - 2013
Ischemic postconditioning has been reported to reduce infarct size in patients with ST-segment elevation myocardial infarction (STEMI). However, cardioprotective effects of postconditioning have not been demonstrated in a large-scale trial. We performed a multicenter, prospective, randomized, open-label, blinded endpoint trial. A total of 700 patients undergoing primary percutaneous coronary intervention ...
Spacek Miloslav - - 2013
Alcohol septal ablation has become a common method to relieve left ventricular outflow track gradient in selected patients with hypertrophic obstructive cardiomyopathy. There is only limited knowledge regarding inadvertent remote (nontarget) myocardial necrosis caused by septal collateral recruitment. Herein we describe a case of unexpected contrast medium leakage through newly ...
Sonmez Osman - - 2013
Little is known about whether estimated glomerular filtration rates (eGFR) affect left ventricular (LV) function and gain benefit with antiremodeling treatment in patients with ST-elevation myocardial infarction (STEMI). We investigated the effect of eGFR on LV function using tissue Doppler imaging (TDI) parameters. In addition, we sought to evaluate the ...
Jang Sung-Won - - 2013
Left anterior line (LAL) has been used as a substitute for mitral isthmus line for catheter ablation of chronic atrial fibrillation (AF). However, it results in left anterolateral conduction delay and might affect left atrial (LA) contractility. We aimed to investigate whether LAL decreases LA appendage function. This study included ...
Romppanen Hannu - - 2013
Background. The BASE-ACS trial demonstrated an outcome of the titanium-nitride-oxide-coated bioactive stents (BAS) statistically non-inferior to that of the everolimus-eluting stents (EES) at 12-month follow-up in patients presenting with acute coronary syndrome (ACS). We performed a post hoc analysis of the BASE-ACS trial with particular focus on stent-oriented versus patient-oriented ...
Satoh Shinji - - 2013
We evaluated a hypothesis that thrombus aspiration with distal protection is superior to simple thrombus aspiration in patients treated with primary percutaneous coronary intervention (PCI). A total of 176 consecutive patients with ST-segment elevation myocardial infarction were enrolled in this study and assigned to either the thrombus aspiration group (A, ...
Vrtovec Bojan - - 2013
In an open-label blinded study, we compared intracoronary and transendocardial CD34(+) cell transplantation in patients with nonischemic dilated cardiomyopathy. Of the 40 patients with dilated cardiomyopathy, 20 were randomized to receive intracoronary injection and 20 received transendocardial CD34(+) cell delivery. In both groups, CD34(+) cells were mobilized by filgrastim, collected ...
Balli Sevket - - 2013
We sought to investigate whether echocardiography with tissue Doppler imaging identifies myocardial dysfunction in children with benign joint hypermobility syndrome (BJHS). This cross-sectional study enrolled 75 children with BJHS and 70 healthy children. We performed detailed echocardiography in individuals with BJHS without inherited connective tissue disorders. Any congenital or acquired ...
Panizo Sara - - 2013
Left ventricular hypertrophy (LVH), a common complication in chronic kidney disease (CKD), is associated with high cardiovascular mortality. The aim of this experimental study was to analyze the effect of different vitamin D receptor activators (VDRAs) on both LVH and myocardial fibrosis in chronic renal failure (CRF). Male Wistar rats ...
Hamdani Nazha - - 2013
-Obesity and diabetes are important metabolic risk factors and frequent comorbidities in heart failure with preserved ejection fraction (HFPEF). They contribute to myocardial diastolic dysfunction (DD) through collagen deposition or titin modification. The relative importance for myocardial DD of collagen deposition and titin modification was investigated in obese, diabetic ZSF1 ...
Song B - - 2013
In this study, electrical and structural remodeling of ventricles was examined in tachycardia-induced heart failure (HF). We studied two groups of weight-matched adult male mongrel dogs: a sham-operated control group (n=5) and a pacing group (n=5) that underwent ventricular pacing at 230 bpm for 3 weeks. Clinical symptoms of congestive ...
Lee Cheol Whan - - 2013
A comprehensive evaluation of culprit coronary lesions may help to understand vulnerable plaques responsible for ST-segment elevation myocardial infarction (STEMI). We compared intravascular ultrasound (IVUS) and histological findings in culprit coronary plaques from 94 patients with STEMI (n = 54) or stable angina (n = 40). Tissue specimens were obtained by directional coronary atherectomy ...
Yamazaki Takanori - - 2013
Tolvaptan, a non-peptide V2-receptor antagonist, is a newly developed diuretic agent. Recently, we reported that tolvaptan has diuretic as well as anti-inflammatory and anti-fibrotic actions in chronic heart failure. In this study, we investigated whether tolvaptan has a cardioprotective effect in acute heart failure after myocardial infarction (MI). After MI ...
Cakar Mehmet Akif - - 2013
Patients with non-ST-elevation acute coronary syndrome are heterogeneous in terms of clinical presentation and immediate- and long-term risk of death or non-fatal ischemic events. The aim of the present study was to evaluate the relationship between the Global Registry of Acute Coronary Events (GRACE) score and severity of coronary artery ...
Lei Pu-Ping - - 2013
Extracorporeal shock wave (SW) therapy ameliorates cardiac remodeling after acute myocardial infarction (AMI). However, it remains to be examined whether and how SW therapy ameliorates myocardial fibrosis after AMI. Fibrocytes are associated with myocardial fibrosis. Thus, we examined whether SW therapy ameliorates myocardial fibrosis and whether fibrocytes are associated after ...
Zhao Huiqiang - - 2013
The present study was designed to investigate whether microvascular remodeling could occur in hibernating myocardium and infarction regions distal to a total occluded coronary artery after acute myocardial infarction. Copper stents were implanted in the left descending coronary arteries of 64 pigs to induce anterior wall myocardial infarction. The pigs ...
Fullwood Joyce E - - 2013
Background Alcohol withdrawal syndrome, characterized by confusion, agitation, and hallucinations, decreases the safety of patients with acute myocardial infarction. Unexpected hospitalization and sudden cessation of alcohol consumption may increase in-hospital complications and length of stay and even precipitate death. Purpose To perform a randomized evaluation of lorazepam and ethanol/lorazepam to ...
Kim Jiwon - - 2013
Newer troponin assays provide high sensitivity and precision and are reported in a stratified manner by some laboratories. We sought to investigate the clinical impact of such reporting in the treatment of patients with suspected acute coronary syndrome (ACS). We identified patients presenting with suspected ACS over a one-year period. ...
Toprak G - - 2013
The differences in concentrations of biomarkers between heart failure patients with dilated cardiomyopathy (HF-D) and with ischemic cardiomyopathy (HF-I) have yet to be defined. The objectives of this study were to compare the concentrations and correlation of biomarkers of inflammation, extracellular matrix (ECM) turnover and oxidative stress parameters between these ...
Sonmez Osman - - 2013
Strain and strain rate imaging is currently the most popular echocardiographic technique that reveals subclinical myocardial damage. There are currently no available data on this imaging method with regard to assessing right ventricular involvement in anterior myocardial infarction. Therefore, we aimed to evaluate right ventricular regional functions using a derived ...
Ehsan Qureshi Azmat A Azmat Ehsan Qureshi, MBBS, FCPS (MED), Post graduate trainee for FCPS Cardiology, Punjab Institute of Cardiology, Lahore, - - 2013
Background and objective: The association between serum uric acid and ischemic heart disease remains controversial and it has not yet been established as cardiovascular risk factor. Our objective was to study the association of serum uric acid level with angiographic severity of coronary artery disease in men with acute coronary ...
Candan Ozkan O Kartal Kosuyolu Heart and Research Hospital, Cardiology Clinic, Kartal, Istanbul, Turkey. - - 2013
Radial and longitudinal movements of the heart do not fully reflect cardiac hemodynamics and physiology. Twist deformation of the heart is essential for adequate cardiac filling and stroke volume. The study aim was to examine the effects of mitral valve replacement or repair on left ventricular rotational parameters, evaluated by ...
Chhapra Daanish Aijaz DA Department of Medicine, Krishna Institute of Medical Sciences University, Karad 415 110, Maharashtra, - - 2013
Right ventricular infarction, previously thought to be rare and recently thought to be common, is commonly associated with inferior wall myocardial infarction. We will hereby study the clinical profile of right ventricular infarction (as diagnosed by right precordial electrocardiography) in patients with acute inferior wall myocardial infarction and the clinical ...
Qiao-Xiang Yin - - 2013
<p>Objective To evaluate the efficacy of cyclosporine A-nanoparticles emulsion(CsA-NP)combined with adipose tissue-derived stem cells(ASCs)transplantation therapy for acute myocardial infarction(AMI)in a miniswine model.Methods CsA-NP emulsion was prepared by the high-pressure homogenization method.Models were performed by coronary angioplasty for percutaneous balloon occlusion of left anterior descending artery(LAD).A total of 17 miniswines survived ...
Erdo─čan Ercan - - 2013
Cardiac involvement has been increasingly recognized in patients with polycystic ovary syndrome (PCOS). Identification of the earliest asymptomatic impairment of left ventricular (LV) performance may be important in preventing progression to overt heart failure. Our aim was to investigate LV function with different echocardiographic techniques in patients with PCOS. Thirty ...
Lee Seung-Pyo - - 2013
Severe aortic stenosis (AS) patients with late gadolinium enhancement (LGE) on cardiovascular magnetic resonance (CMR) or left ventricular (LV) systolic dysfunction on echocardiography are known to have worse outcome. We aimed to investigate whether LGE on CMR would be useful in early detection of subclinical LV structural and functional derangements ...
Viikilä Juho J Department of Cardiology, Helsinki University Central Hospital, - - 2013
Current guidelines prefer primary percutaneous coronary intervention (pPCI) over fibrinolysis in the treatment of acute ST-elevation myocardial infarction (STEMI). Pre-hospital fibrinolysis followed by early invasive evaluation is an alternative that we have used in patients presenting within three hours of symptom onset. We made a survey of patients suffering an ...
Liu Xiangyong - - 2013
To compare the efficacy and safety of combined treatment with thrombus aspiration and intracoronary tirofiban in patients with acute myocardial infarction (MI), with elective percutaneous coronary intervention (PCI). Patients undergoing elective PCI during recovery from acute MI were randomized into two groups; the intervention group received thrombus aspiration and intracoronary ...
Nafasi Latifeh - - 2013
Abstract Background: Periprocedural myocardial infarction (MI) is a common complication following percutaneous coronary intervention (PCI) and statins have been shown to reduce MI in statin-naïve patients. We aimed to identify if a high reloading dose of atorvastatin can prevent MI following PCI in patients who were already being treated with ...
Ling Zhi-Yu - - 2013
The myocardial microenvironment plays a decisive role in the survival, migration and differentiation of stem cells. We studied myocardial micro-environmental changes induced by ultrasound-targeted microbubble destruction (UTMD) and their influence on the transplantation of mesenchymal stem cells (MSCs). Various intensities of ultrasound were applied to the anterior chest in canines ...
Díaz de la Llera Luis S - - 2013
In primary angioplasty, bivalirudin is superior to treatment with heparin plus glycoprotein inhibitors for reducing cardiovascular events, although bivalirudin increases the risk of stent thrombosis. Our hypothesis is that the use of prasugrel plus bivalirudin in primary angioplasty would reduce stent thrombosis and cardiovascular events. Consecutive patients with acute ST-segment ...
Zhang Lei - - 2013
It is reported that ischemic penumbra is a dynamic process, in which irreversible necrosis in the center of ischemia propagates to the neighboring tissue over time. Recent research has indicated that mitochondrial adenosine triphosphate (ATP)-sensitive potassium channels (mitoKATP) opener diazoxide plays an important role in cerebral protection; however, the role ...
Pujadas Sandra - - 2013
Percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) of a coronary artery can provide benefits in terms of myocardial function and survival but the procedure is complex and the success rate is relatively low. To assess these benefits, myocardial function, ischemia and viability should be clearly determined by means ...
Nayyar Sachin - - 2013
QT variability (QTV) signifies repolarization lability and increased QTV is a risk predictor for sudden cardiac death. The aim of this study was to investigate the role of autonomic nervous system activity on QTV. The study was performed in 29 subjects: 10 heart failure patients with spontaneous ventricular tachycardia [HFVT(+)], ...
Nour Sayed - - 2013
Ischemic heart disease (IHD) is a leading cause of mortality with insufficient results of current therapies, most probably due to maintained endothelial dysfunction conditions. Alternatively, we propose a new treatment that promotes endothelial shear stress (ESS) enhancement using an intrapulmonary pulsatile catheter. Twelve piglets, divided in equal groups of 6: ...
Geens Jef H - - 2013
Full unloading of the left ventricle (LV) in chronic heart failure (CHF) induces reversal of LV dilation and geometric distortion. In this study we describe the partial unloading effects in ischemic CHF. Six weeks after myocardial infarction, sheep were randomized to partial support ("pump," n = 5), as provided by ...
Turkmen S - - 2013
ST segment elevation myocardial infarction (STEMI) is an important cause of the morbidity and mortality in coronary artery disease. The aim of this study is to investigate the relationship between hematologic parameters and post primary PCI coronary no-reflow. A total of 145 consecutive STEMI patients (mean age=58.2±12.3 years) and healthy ...
Qian Geng - - 2013
Although cardiac rupture (CR) is a fatal mechanical complication of acute myocardial infarction (AMI), to date no predictive model for CR has been described. CR has common pathological characteristics with major bleeding. We aimed to investigate the relationship between the risk factors of major bleeding and CR. A total of ...
Yamada Takashi - - 2013
Mitochondrial damage is associated with histologic myocardial fibrosis. Late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) can be used to identify focal fibrosis. We examined whether myocardial fibrosis on CMR and collagen volume fraction (CVF) from biopsies correlated with left ventricular (LV) and mitochondrial function in patients with nonischemic dilated ...
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