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Yoshino Satoshi S Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic and College of - - 2014
Background: Myocardial bridging (MB) results in compression of the coronary artery lumen in systole, extending into diastole with resultant hemodynamic alternation as reflected by fractional flow reserve (FFR). MB has also been associated with coronary endothelial dysfunction. The objective of this study was to investigate relationship between FFR with dobutamine challenge ...
Zhao X J XJ Department of Cardiology, Affiliated Hospital of Binzhou Medical University, Binzhou, - - 2014
The mechanisms of statins relieving the no-reflow phenomenon and the effects of single-dose statins on it are not well known. This study sought to investigate the effects of inflammation on the no-reflow phenomenon in a rabbit model of acute myocardial infarction and reperfusion (AMI/R) and to evaluate the effects of ...
Tanaka Akihito A Department of Cardiology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan, - - 2014
Clopidogrel loading is a standard method to achieve rapid platelet inhibition and prevent thrombotic events. At the current time, little information is available to determine the effect of adjunctive cilostazol compared with clopidogrel loading. We retrospectively analyzed 212 patients undergoing primary percutaneous coronary intervention with drug-eluting stents for ST-segment elevation ...
Bajwa Hisham Z HZ Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, - - 2014
To provide direct evidence that mechanical obstruction of microvessels inhibits infarct resorption (healing) and enhances left ventricular (LV) remodeling using MRI. Animals (n = 20 pigs) served as controls (group I) or were subjected to either 90 min left anterior descending (LAD) coronary artery occlusion/reperfusion (group II) or 90 min ...
Woo Seong-Ill SI Department of Cardiology, Inha University Hospital, Incheon, South - - 2014
Aims: We aimed to investigate whether thrombus aspiration could preserve the index of microcirculatory resistance (IMR) after primary percutaneous coronary intervention (PCI) in patients with ST-elevation myocardial infarction (STEMI). Methods and results: Sixty-three patients with STEMI were randomised into two groups: primary PCI after thrombus aspiration (aspiration group, n=33) and ...
Demir Tuncer T Department of Medical Physiology, Faculty of Medicine, University of Gaziantep, 27310, Gaziantep, - - 2014
In the present study, the expression levels of TRPM1, TRPM2, TRPM3, TRPM4, TRPM5, TRPM6, TRPM7, and TRPM8 genes were evaluated in heart tissues after ischemia/reperfusion (IR). For this study, 30 albino male Wistar rats were equally divided into three groups as follows: Group 1: control group (n:10), Group II: ischemia ...
Yamakawa Kentaro K Department of Anesthesiology, David Geffen School of Medicine, University of California, Los Angeles, - - 2014
The current commonly used cardiac ischemic preconditioning (IPC) protocol, involving three 5-min cycles of ischemia-reperfusion (I/R), may not be clinically beneficial because of its acutely deleterious effects on hemodynamics. This study attempted to assess the effects of a novel stepwise IPC scheme on cardiac function, infarct size, and arrhythmogenesis in ...
Gerbaud Edouard E Soins intensifs cardiologiques - plateau de cardiologie interventionnelle, hôpital Haut-Lévêque, Pessac, France; Institut de rythmologie et de modélisation cardiaque LIRYC, CHU/université de Bordeaux/Inserm U1045, Pessac, France. Electronic address: - - 2014
Heart rate is a major determinant of myocardial oxygen demand; in ST-segment elevation myocardial infarction (STEMI), patients treated with primary percutaneous intervention (PPCI), heart rate at discharge correlates with mortality. Ivabradine is a pure heart rate-reducing agent that has no effect on blood pressure and contractility, and can reverse left ...
Prunier Fabrice F Service de Cardiologie, EA 3860, Laboratoire Cardioprotection, Remodelage et Thrombose, Université Angers, CHU Angers, rue Haute de Reculée, 49045, Angers, France, - - 2014
Local ischemic postconditioning (IPost) and remote ischemic perconditioning (RIPer) are promising cardioprotective therapies in ST-elevation myocardial infarction (STEMI). We aimed: (1) to investigate whether RIPer initiated at the catheterization laboratory would reduce infarct size, as measured using serum creatine kinase-MB isoenzyme (CK-MB) release as a surrogate marker; (2) to assess ...
Değirmencioğlu Aleks A Acibadem University, School of Medicine, Department of Cardiology. - - 2014
Although moderate to severe diastolic dysfunction seems to be associated with poor prognosis after isolated coronary bypass surgery, the impact of mild diastolic dysfunction is not investigated extensively in this group of patients. We evaluated the prognostic implication of mild left ventricular diastolic dysfunction on outcome after isolated coronary bypass ...
Chen Jinling J Department of Echocardiography, Renmin Hospital, Wuhan University, Wuhan, Hubei Province, China. Electronic address: - - 2014
A number of studies have shown that the transplantation of bone marrow-derived mesenchymal stem cells (BMSCs) into the thinned infarct wall improves regional wall motion. In this study, we hypothesized that the injection of biomaterials and MSCs into the infarcted myocardium can preserve left ventricular (LV) function. To test this ...
Pan Kuo-Li KL Division of Cardiology, Chang Gung Memorial Hospital, Chiayi, Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Division of Allergy and Immunology and Rheumatology, Division of Nephrology, Chang Gung Memorial Hospital, Chiayi and Division of Cardiology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, - - 2014
Objective. The aim of the present study was to investigate the effect of gout on left ventricular (LV) diastolic function and left atrial volume (LAV).Methods. A total of 173 patients were divided into four groups: control (n = 35), asymptomatic hyperuricaemia (n = 30), gouty arthritis without tophi (n = ...
Buchholz Bruno B aInstitute of Cardiovascular Physiopathology, Department of Pathology, School of Medicine, University of Buenos Aires, Argentina. JE Uriburu 950 - 2nd floor. (1114), Buenos Aires - Argentina. bInstitute of Chemistry and Biological Physical Chemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina. Junín 954 - 2nd floor. (1113). Buenos Aires - - - 2014
The α1-adrenergic receptors (α1-ARs) are involved in preconditioning. Given that certain intracellular pathways appear to be shared by preconditioning and postconditioning, it is possible that postconditioning could be also mediated by α1-ARs. The objective was to evaluate, by analyzing infarct size, if α1-ARs activation could trigger postconditioning; and also determine ...
Güngör Barış B Department of Cardiology, Siyami Ersek Cardiovascular and Thoracic Surgery Center, 34087, Istanbul, - - 2014
Background: The effectiveness of primary percutaneous coronary intervention (PCI) in ST segment elevation myocardial infarction (STEMI) is well established. The clinical variables associated with poor prognosis in patients with STEMI have been extensively investigated. Right coronary artery (RCA) has two anatomical variations detected on coronary angiography namely C-shaped and sigma ...
Agarwal Rajiv R Department of Medicine, Indiana University School of Medicine and Richard L. Roudebush Veterans Administration Medical Center, Indianapolis, IN, - - 2014
The purpose of this study was to determine among maintenance hemodialysis patients with echocardiographic left ventricular hypertrophy and hypertension whether in comparison with a β-blocker-based antihypertensive therapy, an angiotensin converting enzyme-inhibitor-based antihypertensive therapy causes a greater regression of left ventricular hypertrophy. Subjects were randomly assigned to either open-label lisinopril (n ...
Gonçalves Susana S Departamento de Cardiologia, Instituto Cardiovascular de Lisboa, Lisboa, Portugal; Serviço de Cardiologia, Centro Académico de Medicina de Lisboa, Hospital de Santa Maria, CCUL, Lisboa, Portugal. Electronic address: - - 2014
Introduction The spectrum of hypertensive heart disease is wide, and can include left ventricular dysfunction. The development of echocardiographic parameters to improve patient stratification and to identify early adverse changes could be clinically useful. Aim To identify subclinical left ventricular dysfunction in hypertensive subjects with preserved ejection fraction (>55%), identified ...
Fujii Toshiharu T Division of Cardiology, Tokai University School of Medicine, Isehara, - - 2014
Reducing total ischemic time is important in achieving better outcome in ST-segment elevation myocardial infarction (STEMI). Although the onset-to-door (OTD) time accounts for a large portion of the total ischemic time, factors affecting prolongation of the OTD time are not established. The purpose of this study was to determine the ...
Andreini Daniele D Centro Cardiologico Monzino, IRCCS, Via C. Parea 4, 20138 Milan, Italy; Department of Clinical Sciences and Community Health, Cardiovascular Section, University of Milan, Milan, Italy. Electronic address: - - 2014
Reliability of coronary angiography by multidetector row CT (MDCT-CA) for stent evaluation is still a matter for debate, and it is unknown whether contrast medium characteristics may affect diagnostic performance of MDCT-CA. We compared iomeprol-400 with iodixanol-320 to evaluate coronary stents with MDCT-CA. We randomly assigned 254 patients undergoing coronary ...
Mroziński Paweł - - 2014
Several studies have highlighted that volatile anaesthetics improve myocardial protection in cardiopulmonary bypass coronary surgery. However, the haemodynamic effect of desflurane in off-pump coronary surgery has not been clarified yet. Our study hypothesis was that desflurane-fentanyl anaesthesia could decrease myocardial injury markers and improve haemodynamics compared to propofol-fentanyl in patients ...
Pan Qiao Q 1. Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, - - 2014
Extracellular superoxide dismutase (ecSOD) is a unique scavenger of superoxide anions and a promising target of gene therapy for ischemia/reperfusion injury (I/R). However, conventional gene therapies have limitation in effectiveness and efficiency. This study aimed to investigate the protective effects of ecSOD gene modified bone marrow mesenchymal stromal cells (BMSCs) ...
Ding Wenxiao W Department of Respirology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, - - 2014
Obstructive sleep apnea syndrome (OSAS) is associated with many cardiovascular disorders such as heart failure, hypertension, atherosclerosis, and arrhythmia and so on. Of the many associated factors, chronic intermittent hypoxia (CIH) in particular is the primary player in OSAS. To assess the effects of CIH on cardiac function secondary to ...
Salarifar Mojtaba M Department of Cardiology, Tehran University of Medical Sciences, Tehran Heart Center Hospital, Tehran, IR - - 2014
Before primary percutaneous coronary intervention (PCI) in patients with ST elevation myocardial infarction (STEMI), it is not clear whether a routine early administration of glycoprotein IIb/IIIa inhibitors in the emergency ward is beneficial or their administration in selected cases in the catheterization laboratory. The present randomized clinical trial sought to ...
Helseth Ragnhild R 0000-0001-5012-9214 Department of Cardiology, Oslo University Hospital Ullevål, P.O. Box 4956, Nydalen, 0424 Oslo, Norway ; Faculty of Medicine, University of Oslo, P.O. Box 1078, Blindern, 0316 Oslo, - - 2014
Background. High levels of Pentraxin 3 (PTX3) are reported in acute myocardial infarction (AMI). Aim. To investigate circulating levels and gene expression of PTX3 in patients with AMI and stable angina pectoris (AP) undergoing PCI. Methods. Ten patients with AP and 20 patients with AMI were included. Blood samples were ...
Liu Daliang D 0000-0002-3496-2174 Department of Radiology, Beijing Friendship Hospital, Capital Medical University, 95 Yongan Road, Xicheng District, Beijing 100050, - - 2014
Objectives. To analyze the predictive value of coronary computed tomography angiography on acute coronary artery events in patients with type 2 diabetes. Methods. Coronary computed tomography angiography was performed in 250 type 2 diabetic patients. After a follow-up for 5 years, 145 patients were excluded as they did not have ...
Hu Hesheng H School of Medicine, Shandong University, Jinan, China; Department of Cardiology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, - - 2014
Nerve growth factor (NGF) is involved in nerve sprouting, hyper-innervation, angiogenesis, anti-apoptosis, and preservation of cardiac function after myocardial infarction (MI). Positively modulating NGF expression may represent a novel pharmacological strategy to improve post-infarction prognosis. In this study, lentivirus encoding NGF short interfering RNA (siRNA) was prepared, and MI was ...
Temiz Ahmet A Department of Cardiology, Çanakkale Onsekiz Mart University, Çanakkale, - - 2014
Background Platelet-to-lymphocyte ratio (PLR) is a new prognostic marker in coronary artery disease. We aimed to evaluate the relationship between PLR and in-hospital mortality in patients with ST-elevated acute myocardial infarction (AMI). Material and Methods The present study included 636 patients with ST-elevated AMI. The study population was divided into ...
Ran K K Department of Anesthesiology, The Second Xiangya Hospital, Central South University, - - 2014
We examined the protective effects of Ginkgo biloba extract (EGb761) postconditioning on myocardial ischemia reperfusion injury in rabbits. Four groups of 8 white rabbits were allocated to: pseudo surgery group: the left coronary was lined without blocking for 160 min after thoracotomy; ischemia and reperfusion group (IR): the left anterior ...
Yamamoto Yasumasa Y Department of Neurology, Kyoto Second Red Cross - - 2014
Small deep brain infarcts are often caused by two different vascular pathologies: 1. atheromatous occlusion at the orifice of large caliber penetrating arteries termed branch atheromatous disease (BAD) and 2. lipohyallinotic degenerative changes within the course of penetrating arteries termed lipohyalinitic degeneration. Representative vascular territories of BAD type infarcts are ...
Akturk Ibrahim Faruk IF Department of Cardiology, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Halkali, Istanbul, - - 2014
Insulin-like growth factor-1 (IGF-1) has atheroprotective effects via reduction in oxidative stress, cellular apoptosis, pro-inflammatory signaling, and endothelial dysfunction. We hypothesized that low levels of IGF-1 may be associated with the severity and extent of coronary artery disease and development of the coronary no-reflow phenomenon in patients with acute ST-elevation ...
Hu Jialu J Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, - - 2014
Although renal denervation (RD) has been shown to be effective in treating post- myocardial Infarction (MI) heart failure (HF) in animal models and clinical trials, its utility as a standalone treatment without traditional drug treatment for post-MI HF still needs to be investigated. Rats were randomly assigned into seven experimental ...
Chakraborty P K PK Dr Pijush Kumar Chakraborty, Associate Professor, Department of Biochemistry, Mymensingh Medical College, Mymensingh, - - 2014
This case control cross sectional study was carried out in the Department of Biochemistry, Mymensingh Medical College in collaboration with Cardiology Department of Mymensingh Medical College Hospital, Mymensingh during the period of July 2004 to June 2005. The aim of the study was to explore the status of serum magnesium ...
Guo Tong-Shuai TS Department of Cardiovascular Medicine, First Affiliated Hospital of Medical College of Xi'an Jiaotong University, No. 277 Yanta West Road, Xi'an 710061, China. - - 2014
Salt-sensitive individuals show earlier and more serious cardiac damage than nonsalt-sensitive ones. Some studies have suggested that microRNA-133a could reduce cardiac hypertrophy and myocardial fibrosis. The current study aims to investigate the different functions of high-salt intake on salt-sensitive (SS) rats and Sprague-Dawley (SD) rats and the involvement of microRNA-133a ...
Xu Tongda T Research Institute of Cardiovascular Diseases, Xuzhou Medical College, Xuzhou, Jiangsu, China; The First Clinical College, Nanjing Traditional Chinese Medicine University, Nanjing, Jiangsu, - - 2014
The purpose of this study was to observe the effects of salvianolic acid A (SAA) pretreatment on the myocardium during ischemia/reperfusion (I/R) and to illuminate the interrelationships among dual specificity protein phosphatase (DUSP) 2/4/16, ERK1/2 and JNK pathways during myocardial I/R, with the ultimate goal of elucidating how SAA exerts ...
Shi Shaobo S Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China; Cardiovascular Research Institute, Wuhan University, Wuhan, - - 2014
Depression is an independent risk factor for cardiovascular events and mortality in patients with myocardial infarction (MI). Excessive sympathetic activation and serious myocardial remodeling may contribute to this association. The aim of this study was to discuss the effect of depression on sympathetic activity and myocardial remodeling after MI. Wild-type ...
Jinnouchi Hiroyuki H Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, Saitama, - - 2013
Early statin treatment of patients with acute coronary syndrome results in vascular changes and improved clinical outcomes. However, the influence of chronic statin treatment on the culprit vessel in acute coronary syndrome is not fully understood. The aim of this study was to investigate the morphologic features of the culprit ...
Ke-Wu Deng D 1Department of Cardiology, Beijing Anzhen Hospital Affiliated to Capital Medical University, Beijing, - - 2013
Objective:To evaluate the effect of exogenous creatine phosphate (CP) on myocardial injury after percutaneous coronary intervention (PCI).Method:Four hundred patients were divided to receive conventional therapy (control group) or 3-day intravenous infusion of CP after PCI (CP group). Levels of creatine kinase MB (CK-MB) and troponin I (TnI) were measured before ...
Onuma Yoshinobu Y Thoraxcenter, Erasmus Medical Center, Rotterdam, The - - 2013
Aims: Coronary artery disease is often diffuse and patients with non-ST-segment acute coronary syndromes (NSTE-ACS) demonstrate multivessel coronary disease. The purpose of this study was to clarify whether interventions on stable chronic non-culprit lesions in patients with NSTE-ACS can prevent future adverse events. Methods and results: We performed a retrospective ...
Sun Yingxian Y Department of Cardiology, the First Hospital of China Medical University, Shenyang, People's Republic of China. Electronic address: - - 2013
It is necessary to develop a new thrombolytic agent which can be used by a single bolus at first aid sites to decrease the time to reperfusion in clinical practice. HTUPA, a genetically engineered new thrombolytic with a longer half-life, is well qualified. We aim to compare the thrombolytic efficacy ...
Lee Soo Youn SY Department of Internal Medicine, Division of Cardiology, Sejong General Hospital, Bucheon, Republic of - - 2013
Several reports have suggested that thyrotoxicosis may induce severe coronary artery spasm (CAS). However, there are few data regarding the differences in clinical characteristics of CAS with and without thyrotoxicosis. The aim of our study is to compare the clinical features of CAS with and without thyrotoxicosis. We evaluated 430 ...
Zheng Shaohua S Shandong Provincial Qianfoshan Hospital, and the Department of Clinical Medicine, School of Medicine, Shandong University, Jinan City, - - 2013
No evidence has been presented to show whether autonomic neural remodeling occurs in pulmonary vein-left atrium (PV-LA) junction and what an important role it may play in AF. This study aims to find out these issues in a prolonged rapid atrial pacing canine model. Twelve healthy mongrel dogs were randomly ...
Hadi Najah R NR Pharmacological Department, Medical College, Kufa University, - - 2013
Background. Myocardial ischemial reperfusion represents a clinically relevant problem associated with thrombolysis, angioplasty, and coronary bypass surgery. Injury of myocardium due to ischemial reperfusion includes cardiac contractile dysfunction, arrhythmias, and irreversible myocytes damage. These changes are considered to be the consequence of imbalance between the formation of oxidants and the ...
Noguchi Teruo T Department of Cardiovascular Medicine and. Electronic address: - - 2013
We wished to determine whether coronary high-intensity plaques (HIPs) visualized by non-contrast T1-weighted imaging (T1WI) can predict future coronary events.  BACKGROUND: Coronary HIPs are associated with characteristics of vulnerable plaques including positive remodeling, lower Hounsfield units, and ultrasound attenuation. However, it remains unclear whether the presence of HIPs is associated ...
Wu Yun Y Department of Anesthesiology, Zhongnan Hospital of Wuhan University, Wuhan, - - 2013
Butorphanol tartrate is a synthetic opioid partial agonist analgesic. Butorphanol targets the heart, mainly via κ-opioid receptor (κ-OR) activation. The purpose of this study was to determine the effect and mechanism underlying butorphanol postconditioning (B-Post) on myocardial ischaemia reperfusion injury in rats. Seventy-five male Sprague-Dawley rats were randomly divided into ...
Miyase Yuiko Y Department of Cardiology, Fukuoka University School of Medicine, Fukuoka 814-0180, - - 2014
There is considerable evidence that impaired autonomic control may be associated with the etiology of coronary artery disease (CAD). We hypothesized that the autonomic imbalance as assessed by measuring heart rate variability (HRV) and biological parameters before and after coronary angiography (CAG) may predict the presence of CAD. Ambulatory electrocardiographic ...
Akilli Hakan H Department of Cardiology, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, - - 2013
Although elevated red blood cell distribution width (RDW) is associated with adverse outcomes in patients with cardiovascular disease, its role in demonstrating the presence and extent of myocardial ischemia for coronary artery disease is not known. The purpose of this study is to investigate the relationship between RDW and myocardial ...
Yin Qiaoxiang Q Department of Geriatric Cardiology, Chinese General Hospital of the Air Force, Beijing, People's Republic of - - 2014
Treatment of myocardial infarction (MI) with adipose-derived stem cells (ASCs) has produced promising results. Cyclosporine A (CsA) inhibits apoptosis by preventing the opening of mitochondrial permeability transition pores. A CsA nanoparticle emulsion (CsA-NP) has lower toxicity and higher efficiency as compared to CsA. In this study, we hypothesized that a ...
Dogan Mehmet - - 2013
Objectives: In this study, we aimed to investigate the relationship between neutrophil to lymphocyte ratio (NLR) and infarct-related artery (IRA) patency in patients with ST-segment elevation myocardial infarction (STEMI).Methods: A total of 349 patients with STEMI were recruited to this retrospective study. Baseline characteristics were reviewed. Patency of IRA was ...
Kurtul Alparslan - - 2013
Reduced baseline coronary flow in an infarct-related artery (IRA) before a primary percutaneous coronary intervention (PPCI) increases mortality in patients with ST-elevation myocardial infarction (STEMI). Increased neutrophil/lymphocyte (N/L) ratio has been linked to poor clinical outcomes in patients with STEMI. We investigated whether the N/L ratio, as measured at admission, ...
Huang Xueying X School of Mathematical Sciences, Xiamen University, 422 South Siming Road, Xiamen, Fujian 361005, China; Department of Mathematical Sciences, Worcester Polytechnic Institute, MA 01609, USA. Electronic address: - - 2013
Mechanical forces play an important role in the rupture of vulnerable plaques. This process is often associated with cardiovascular syndromes, such as heart attack and stroke. In this study, magnetic resonance imaging (MRI)-based models were used to investigate the association between plaque wall stress (PWS) and coronary artery disease (CAD). ...
Qin Chuan - - 2013
To investigate two-dimensional (2D) ultrasound speckle tracking imaging (STI) in the evaluation of the early changes in the left ventricular (LV) twist-displacement loop in patients with hypertension (EH). Sixty-five EH patients with left ventricular normal geometry (LVN) - including 33 cases with non-left atrial enlargement (NLAE) and 32 cases with ...
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