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Results 501 - 550 of 553
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Lange H W - - 1983
Thirty-six hearts of patients who died with indwelling Swan-Ganz catheters in place were prospectively examined to assess the incidence and extent of localized lesions in the right side of the heart. Bland mural thrombosis in the superior vena cava, the right atrium and the pulmonary artery was found in 22 ...
Boyko O B - - 1983
A 60-year-old woman with livedo reticularis was examined for defective release of vascular plasminogen activator by a newly described chromogenic assay. Her activator level was only 0.007 Committee on Thrombolytic Agents (CTA) units/mL, compared with a mean of 0.19 CTA units/mL for 84 female controls. Subsequently, the patient died as ...
Goodnough L T - - 1983
Nine patients are described with hereditary clotting factor abnormalities and thrombosis and 35 others previously reported in the literature. An additional 11 patients with myocardial infarction observed by the authors and 12 more reported by others are also included. A patient with non-immune thrombocytopenia and myocardial infarction is presented, as ...
Muller J E - - 1983
There is intense scientific interest in the possibility that the acute administration of a fibrinolytic agent might be of benefit to patients with acute myocardial infarction. This hypothesis, which will soon be tested in a major trial by the National Heart, Lung, and Blood Institute, has emerged from a confluence ...
Norman M G - - 1982
A 6-year-old child with meningitis had a respiratory arrest 20 minutes after a lumbar puncture. Thereafter she required maintenance on a ventilator, had a flaccid quadriplegia, and died 12 days later. Necropsy showed infarction of the central portion of the cord at the level of the decussation of the pyramids. ...
Chiu T - - 1982
We have described a case of coronary thrombosis in a neonate. The diagnosis should be considered in a term infant who presents with a shock-like state with poor perfusion soon after birth. The chest roentgenogram may vary from a normal pattern to generalized cardiomegaly with pulmonary congestion. The electrocardiogram may ...
Zimmermann R - - 1981
In 18 cases with primary subclavian-axillary vein thrombosis fibrinolytic therapy was performed with urokinase in combination with heparin. The thrombolytic efficacy clearly depended on the thrombus age and the dose of urokinase applied. Under treatment with a median initial maintenance dosage of urokinase of 1,000-2,000 IU/kg/h (loading dose 150,000-250,000 IU ...
Fiedler V B - - 1981
Antithrombotic and hemodynamic properties of molsidomine (0.10 mg/kg i.v.) were evaluated in an in-vivo model of coronary artery thrombosis initiated by electrical stimulation for 6 h. Molsidomine prolonged time to vessel occlusion and prevented heart rate and end-diastolic pressure increase and contractility decrease. Infarct size was smaller after drug treatment ...
Ueda K - - 1981
The incidence and pathologic features of cardiac lesions in 184 autopsied aged patients with disseminated intravascular coagulation (DIC) were reported. Coronary thrombosis was noted in 31 (16.8%), fresh myocardial necrosis in 60 (32.6%) and massive myocardial hemorrhage in 49 (26.6%) of these patients. Fresh myocardial infarction was present in 16 ...
Sutton P P - - 1981
The most important and consistent symptom of acute PE is the sudden onset of dyspnoea unexplained by pneumonia, heart failure, pneumothorax, or exacerbation of airway obstruction. The features commonly remembered such as haemoptysis and pleural rub may be absent in up to two thirds of patients. With previous cardiorespiratory disease ...
Little A G - - 1981
Eleven of 16 patients with splenic vein thrombosis subsequent to pancreatitis had variceal hemorrhage. variceal development tends to occur in the stomach, although esophageal varices may also occur, and is a result of left-sided or segmental portal hypertension. The antecedent pancreatitis may be quite mild and produce minimal symptoms. Angiography ...
Romson J L - - 1980
The nonsteroidal anti-inflammatory agent, ibuprofen, was evaluated for its in vivo antithrombotic effects in conscious canines by inducing left circumflex (LCX) coronary artery thrombosis with low amperage stimulation (50 microA for 24 hr) of the intimal surface of the vessel. Oral administration of ibuprofen (75 or 175 mg/kg in divided ...
Ali M - - 1980
The occurrence of thrombotic events is central to the course of polycythemia vera. Myocardial, cerebral, peripheral, and pulmonary infarctions are frequent and are consequences of throbmoses in small and medium caliber arteries. Thrombosis in large caliber arteries is a rare event. Thrombosis within the chambers of the heart has not ...
Rothman S M - - 1980
The most common serious neurologic complication of sickle cell anemia is occlusive vascular disease with central nervous system infarction. The parenchymal lesions are most often located in the brain, chiefly within major cerebral arterial boundary zones. Spinal cord infarction is extremely rare. We report a patient with sickle cell anemia ...
Margulies E H - - 1980
Sulfinpyrazone1 has long been recognised as a potent uricosuric agent, but has more recently been studied extensively as a platelet inhibitor and antithrombotic agent. It is active in man following oral administration and has been reported to be effective in reducing the incidence of transient ischaemic attacks, thromboembolism associated with ...
Gallo J I - - 1980
A series of 122 consecutive patients with left atrial thrombosis is reviewed. Positive diagnosis was achieved in only 40 cases (36%) based on the angiographic findings and the presence of coronary fistula. The main cause of mortality and morbidity was cerebrovascular embolism. A change in our surgical technique, including the ...
Mizutani T - - 1980
A 28-year-old woman with a long history of drug abuse experienced flaccid quadriplegia and bilateral loss of posterior column sensation a few minutes after an intravenous (IV) injection of methylphenidate hydrochloride. Subsequently, spasticity developed and she showed minimal functional improvement during a period of several months. Necropsy performed 8 1/2 ...
Pitney W R - - 1980
A trial was undertaken to compare the effectiveness of the antiplatelet drug, flurbiprofen, and subcutaneous heparin in the prevention of deep vein thrombosis following acute myocardial infarction. The original aim of the study could not be fulfilled as the incidence of isotopically-determined venous thrombosis in the group of control patients ...
Zivin J A - - 1980
The study of focal central nervous system ischemia has been impeded by the lack of animal models that are both reproducible and simulate human ischemic strokes. To circumvent these problems, we have developed a rabbit spinal cord infarction model. Infarction of the caudal lumbar cord is produced by temporary occlusion ...
Simmonds J P - - 1980
34 patients with myocardial infarction were studied with daily measurements of beta-thromboglobulin (BTG) and 125I fibrinogen scanning in order to detect deep-venous thrombosis (DVT). Serial levels of BTG were unhelpful in the early detection of this condition, which occurred in 7 of the patients studied. 5 of the patients with ...
Smith R O - - 1979
Submucosal cordectomy, an old procedure first described for the treatment of bilateral abductor vocal cord paralysis, was used to relieve glottic or minimal subglottic stenosis in four patients. Three attained adequate airways with no further procedures; one required subsequent dilations for granulation tissue after which decannulation was successfully effected. Although ...
Kelly D F - - 1979
Salivary gland infarction was found in two adult dogs. The main changes were ischaemic necrosis, capsular fibrosis and regenerative hyperplasia of surviving ductal epithelium. Necrosis of arterial tunica media and thrombosis were found only in the infarcted parts of the salivary glands. The lesions appeared to be confined to the ...
Hansen B F - - 1979
Thrombosis of epicardial coronary veins was demonstrated in 16 of 50 cases of left ventricular acute myocardial infarction and/or recent coronary arterial thrombosis. All patients with valvular heart disease had venous thrombosis. In cases without valvular heart disease, venous thrombosis was seen in infarctions involving more than 30% of the ...
Ross E D - - 1979
Clinical evidence is presented which establishes for the first time that position and vibration sensations may be carried in the dorsal spinocerebellar tracts. We present a patient who incurred a spinal cord infarction eight months prior to death that caused a Brown-Séquard syndrome with loss of position and vibration senses ...
Branwood A W - - 1978
One hundred twenty-one patients who died from myocardial infarction were studied. Occlusive coronary artery thrombosis was present in 32%. In 68% of these, the infarct developed first. Factors inducing thrombus formation include fall in systemic blood pressure, alteration of blood flow, shock, and size of infarct. Factors inducing infarction, apart ...
Tyras D H - - 1978
In a patient receiving intraaortic balloon counterpulsation following myocardial revascularization, paraplegia developed two days post-operatively. Postmortem examination demonstrated a dissecting hematoma of the thoracic aorta and spinal cord infarction. The neurological deficit is thought to be due to embarrassment of spinal cord blood supply, and mechanisms of injury are discussed.
Steele P - - 1978
Platelet survival time was measured in eight men who had an acute transmural myocardial infarction and were subsequently found to have a normal coronary arteriogram. Platelet survival (chromium-51 labeling) was shortened in all men (2.4 +/- 0.11 days; average half-time +/- standard error of the mean) and different from that ...
Slauson D O - - 1978
Syrian hamsters developed spontaneous renal lesions that resembled those of arteriolar nephrosclerosis in man, and differed from other spontaneously occurring or virus-induced renal diseases in other rodent species. Morphologic changes were mainly degenerative with little cellular exudation and were associated with histologic changes in the intrarenal vasculature. The renal lesions ...
Mel'man E P - - 1978
By angioroentgenography, macro- and microscopic examinations the authors investigated the plasticity of intramural blood drainage vessels and the histological structural lesions of venous walls in 50 heart preparations of patients suffering from atherosclerotic heart disease (AHD) that had developed on the basis of coronary sclerosis varying in degree and localization, ...
McMartin D N - - 1977
Many of the aging Syrian hamsters maintained in our Division spontaneously develop atrial thrombosis accompanied by a consumption coagulopathy. The 50% mortality level is reached earlier by females (16 months) than by males (24 months). The incidence of thrombosis increases with age, beginning at 13.5 months in females and at ...
Kairaluoma M I - - 1977
The most common etiologies of mesenteric infarction in fifty-one patients were arterial thrombosis (in 42 per cent), bowel infarction without major vessel occlusion (in 28 per cent), and arterial embolus (in 22 per cent), but the etiology also included some very rare vascular diseases--two cases of the malignant atrophic papulosis ...
Sugiura M - - 1977
Diagnosis of disseminated intravascular coagulation (DIC) was made in 64 cases (16.2%) among a total of 395 autopsy cases. There were 31 men and 33 women. Their ages ranged from 31 to 91 years (mean 76.3). Underlying diseases were mainly malignancy and sepsis. Fresh cardiac lesions were found in 40 ...
Emerson P A - - 1977
A trial of low-dose subcutaneous heparin to prevent thromboembolic complications after myocardial infarction was carried out in 78 patients. Of the 37 heparin-treated patients only two (5%) developed evidence of leg vein thrombosis, while 14 (34%) of the 41 controls did so, and five controls developed pulmonary emboli. Leg vein ...
Davies D - - 1976
When pneumoconiosis makes a material contribution to a miner's death benefit is paid to his widow. Doctors from the Department of Health and Social Security have argued that extensive pneumoconiosis not only does not increase the risks of death if coronary thrombosis develops but also that it may exert a ...
Hayes M J - - 1976
In a prospective study of patients admitted to a coronary care unit, the incidence of isotopically diagnosed deep venous thrombosis was found to be related to the severity of illness rather than to the duration of bed rest. In addition, no negative correlation was found between cigarette smoking and deep ...
Frisbie J H - - 1976
Cardiac survey following administration of 131-1 autologous fibrinogen is a noninvasive technique for the detection of intracardiac thrombosis. Fibrinogen is isolated from plasma by a rapid salting-out method with ammonium sulfate and is iodinated with chloramine T. The purity of 131-fibrinogen, expressed as clottable radioactivity, is greater than 90%. Cardiac ...
OConnor P J - - 1976
Extensive infarction of the liver, initially thought to be halothane hepatitis, is described. The patient developed severe right upper quadrant abdominal pain and abnormal liver function tests after amputation of the leg. The correct diagnosis was made by percutaneous needle biopsy of the liver which demonstrated a large area of ...
Jones M W - - 1976
Cervical myelopathy has become commonly recognized as a complication of rheumatoid atlantoaxial subluxation. A small group of patients with atlantoaxial subluxation may have intermittent symptoms associated with change of head position and which are due to vertebral artery compression. Two such cases are reported, one with necropsy findings of infarction ...
Godwin-Austen R B - - 1975
Three cases of radiation myelopathy are reported. Corticosteroid therapy was associated with worth-while remissions in 2 patients. Two patients showed swelling of the spinal cord in myelograms and in one it extended below the irradiated part of the spinal cord. Demyelination of the dorsal white columns of the spinal cord ...
Uys C J - - 1975
The autopsy findings in a White man aged 59 years are presented; he underwent heterotopic cardiac transplantation with left ventricular bypass for irreversible left ventricular failure caused by severe ischaemic heart disease. Microscopically, the donor heart showed mild signs of chronic rejection with negligible loss of functional myocardium, and no ...
Harris P - - 1975
Evidence is discussed which suggests that coronary arterial thrombosis need not be the primary event in myocardial infarction. If this is so, it is necessary to consider the initial changes which might occur in the myocardium rather than the effects of experiments in which the coronary arterial supply has been ...
Benisch B M - - 1975
Benisch, Barry M., and Howard Rudolf G.: Lymph-node infarction in two young men. Am J Clin Pathol 63: 818-823, 1975. Two cases of massive lymph-node infarction in young men are described. Both patients had fever and lymphadenopathy and findings that suggested the possibility of viral infection. Follow up has revealed ...
Griffiths R W - - 1975
A patient with observed acute collapse of a lumbar vertebral body developed cauda equina compression. He was known to have contracted syphilis some 20 years before and, while he may well have suffered from tabetic spinal neuroarthropathy, histology of the collapsed vertebra showed features which indicate that an intra-osseous gumma ...
Rawles J M - - 1975
The local fibrinolytic activity generated in the leg and arm veins during venous occlusion (fibrinolytic capacity) and the systemic fibrinolytic activity were measured at intervals in 11 patients after fracture of the femoral shaft and in 11 patients after acute myocardial infarction. In both groups the fibrinolytic capacity of the ...
Farrer-Brown G - - 1975
A detailed injection, microradiographic, and histological necropsy study of 18 hearts showed that the pattern of myocardial veins differed from the arterial pattern. In "normal" hearts, large drainage veins began in the subendocardial zone and coursed fairly directly towards the epicardium, maintaining a comparatively even calibre throughout. Smaller, but similar, ...
Handley A J - - 1974
As part of a study of the factors affecting the risk of deep vein thrombosis after myocardial infarction a surprising and unexplained finding was that non-smokers had a significantly higher incidence of thrombosis than cigarette smokers.
Marks P - - 1974
Out of 102 patients with cardiac infarction admitted to the coronary care unit at this hospital and not treated with anticoagulants 30 (29%) developed isotopic evidence of deep vein thrombosis. Of the 65 smokers only 7 (11%) developed a deep vein thrombosis, whereas of the 37 non-smokers 23 (62%) developed ...
Shafar J - - 1974
The percentage nitroblue-tetrazolium (NBT) leucocyte levels were evaluated daily in the 10 days following a first attack of coronary thrombosis. In 12 uncomplicated cases the peak increase was on the second or third day; thereafter the level declined and was below 10% by the tenth day. Three other patients did ...
Davies J D - - 1972
Five cases of extensive infarction of lymph nodes were traced in just over 16 years' surgical material. All presented with painful swelling in a superficial lymph node chain. None was diagnosed clinically; two were interpreted as fibroadenoma of the axillary tail of the breast, and two as a femoral hernia. ...
Handley A J - - 1972
A trial of continuous intravenous heparin in the prevention of deep vein thrombosis was undertaken in 48 patients who had suffered a myocardial infarction. Of the 24 control patients who did not receive heparin seven (29%) developed calf vein thrombosis as detected by the radioactive fibrinogen technique. None of the ...
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