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Wolkers Willem F WF Institute of Multiphase Processes, Leibniz Universität Hannover, Callinstrasse 36, D-30167, Hannover, Germany, - - 2015
Decellularized xeno-antigen-depleted porcine pulmonary heart valves tissues may be used as matrix implants for patients with malfunctioning heart valves. Decellularized tissues are biological scaffolds composed of extracellular matrix components. Biological scaffolds closely resemble properties of native tissue, but lack immunogenic factors of cellular components. Decellularized heart valve scaffolds need to ...
Kheradvar Arash A Department of Biomedical Engineering, The Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California, Irvine, 2410 Engineering Hall, Irvine, CA, 92697-2730, USA, - - 2014
As the first section of a multi-part review series, this section provides an overview of the ongoing research and development aimed at fabricating novel heart valve replacements beyond what is currently available for patients. Here we discuss heart valve replacement options that involve a biological component or process for creation, ...
Li Vivian W Y VW Division of Pediatric Cardiology, Department of Pediatrics and Adolescent Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, - - 2014
Alteration of right ventricular (RV) function has been found in patients with pressure-loaded left ventricles due to systemic hypertension and aortic stenosis. We tested the hypothesis that RV mechanics are altered in adolescents and adults with repaired coarctation of the aorta (CoA). Twenty-eight (15 male) patients, aged 23.7 ± 6.5 years, and 28 ...
Li Yuling Y Department of Cardiology, The First Hospital of China Medical University, Shenyang, 110001, - - 2014
Slow coronary flow (SCF) is characterized by delayed distal vessel opacification in the absence of significant epicardial coronary disease. Life-threatening arrhythmias and sudden cardiac death can occur; however, the pathological mechanism and influence on left ventricular function remain undetermined. We aimed to assess the risk factors and left ventricular (LV) ...
Taqueti Viviany R VR Brigham and Women's Hospital, Harvard Medical School, Boston, - - 2014
-Minimally elevated serum cardiac troponin (Tn) reflects myocardial injury and is associated with increased mortality, even absent coronary artery disease (CAD). We sought to investigate the relationship between low-level Tn elevation and impaired coronary flow reserve (CFR), an integrated measure of coronary vasomotor function, and assess their contributions to adverse ...
Hansen Kim W KW Department of Cardiology, Copenhagen University Hospital Gentofte, Hellerup, Denmark - - 2014
To examine trends in the use of diagnostic coronary angiography according to distance from home to the nearest invasive heart centre following implementation of fast-track protocols and extensive pre-hospital triaging of acute coronary syndrome patients. We performed a register-based cohort study of all patients admitted to Danish hospitals with incident ...
Cai Anping - - 2014
To investigate relationship between glycated hemoglobin (HbA1c) level and coronary artery disease (CAD) severity METHODS: Observational study was conducted and 573 participants were enrolled and baseline characteristics were collected. Clinical presentations in terms of stable angina, unstable angina or acute myocardial infarction were diagnosed. All participants were performed coronary angiography ...
Ucgun Taner T Department of Biochemistry, Düzce University Faculty of Medicine Hospital, Düzce, - - 2014
The adipocytokines visfatin and omentin have a direct effect on inflammation and endothelial injury. The expression of visfatin is closely associated with the expression of proinflammatory cytokines. Omentin has an anti-inflammatory effect and is inversely associated with coronary artery disease (CAD). The slow coronary flow phenomenon is an angiographic finding ...
Khamooshian Arash A From the *Catharina Hospital, Groningen; and the †University Medical Center Utrecht, Utrecht, the - - 2014
In the past decades, more than 40 mitral valve annuloplasty rings of various shapes and consistency were marketed for mitral regurgitation (MR), although the effect of ring type on clinical outcome remains unclear. Our objective was to review the literature and apply a simplification method to make rings of different ...
Luca Testa T Istituto Clinico S. Ambrogio, Milan, Italy (TL, BF), La Sapienza Univ, Roma, Italy (BZG), European Hospital, Rome (TF), University of Verona, Verona, Italy (RF), Magna Grecia Univ., Catanzaro, Italy (IC); Ferrarotto Hospital, Catania, Italy,(TC), Centro Cardiologico Monzino, Milan, Italy (BA); Pisa Univ, Pisa, Italy (PAS, - - 2014
The Absorb Bioresorbable Vascular Scaffold System (Absorb BVS) is an everolimus-eluting bioresorbable vascular scaffold able to provide temporary scaffolding and antiproliferative drug delivery for the treatment of coronary artery disease. This temporary scaffolding could be the true feature to overcome the limitations of the conventional metallic stents. A growing body ...
Magalhaes Marco A MA From the Division of Cardiology, Department of Internal Medicine, MedStar Washington Hospital Center, - - 2014
Clinical presentation of bare metal stent in-stent restenosis (ISR) in patients undergoing target lesion revascularization is well characterized and negatively affects on outcomes, whereas the presentation and outcomes of first- and second-generation drug-eluting stents (DESs) remains under-reported. The study included 909 patients (1077 ISR lesions) distributed as follows: bare metal ...
Tauchi Yuuya Y Department of Cardiovascular Surgery, Higashi Takarazuka Satoh Hospital, Hyogo, Japan. Electronic address: - - 2014
Myocardial ischemia associated with acute aortic dissection is frequently a fatal complication, and the emergent management still remains a challenge. We report a patient with life-threatening myocardial ischemia due to acute aortic dissection managed by rescue stent grafting of the ascending aorta. Coronary blood flow improved immediately with this endovascular ...
Campisi Salvatore S Department of Cardiovascular Surgery, University Hospital of Saint-Etienne, Saint-Etienne, France. Electronic address: - - 2014
A 33-year-old man underwent urgent coronary artery de-obstruction for acute thrombotic occlusion of the left descending coronary artery. After 10 days of antiplatelet and heparin therapy, ventriculographic and echocardiographic control revealed a giant thrombus in the left ventricle, an ejection fraction of 40%, and severe mitral regurgitation. Heparin-induced thrombocytopenia was ...
Bonaca Marc P MP TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. Electronic address: - - 2014
Vorapaxar, a novel thrombin receptor antagonist, reduces cardiovascular death and recurrent thrombotic events when added to standard antiplatelet therapy in patients with stable atherosclerotic vascular disease. The goal of this study was to test the hypothesis that treatment with vorapaxar reduces the rate of coronary stent thrombosis (ST) in stable ...
Duncker Dirk J DJ Division of Experimental Cardiology, Dept. of Cardiology, Thoraxcenter, Cardiovascular Research Institute COEUR, ErasmusMC, University Medical School, Rotterdam, Rotterdam, The Netherlands. Electronic address: - - 2014
The major factors determining myocardial perfusion and oxygen delivery have been elucidated over the past several decades, and this knowledge has been incorporated into the management of patients with ischemic heart disease (IHD). The basic understanding of the fluid mechanical behavior of coronary stenoses has also been translated to the ...
Rao Golla Maheswara S G MS Division of Cardiology, University of North Carolina, Chapel Hill, NC 27599-7075 USA. - - 2014
Atherosclerosis begins in the teenage years and progresses over time in susceptible individuals. It is unknown, however, whether coronary angiography in middle-aged adults showing no evidence of atherosclerosis identifies individuals at low risk for subsequent development of coronary artery disease (CAD). We identified 4068 patients ≥40 years of age who ...
Meelu Omar A OA Mount Sinai School of Medicine, New York, New York. - - 2014
Percutaneous coronary intervention (PCI) of true bifurcation lesions (Medina classification 1, 1, 1; 1, 0, 1; or 0, 1, 1) is challenging and may involve either a 1-stent strategy with provisional side branch stenting, or a 2-stent strategy. Diabetes mellitus is associated with greater atherosclerotic burden and higher incidence of ...
Adachi Seiji S Department of Gastroenterology, Gihoku Kosei - - 2014
A man in his 70s experienced cardiopulmonary arrest (CPA) due to acute myocardial infarction. He was resuscitated and treated with a multimodal approach, and he fortunately survived CPA without neurological damage. However, abdominal pain and vomiting occurred 45 days after the CPA. Small intestinal endoscopy showed pinhole-like stenosis of the ...
Al Emam Abdel Rahman A AR Department of Internal Medicine, University Of Texas Medical Branch, Galveston, - - 2014
Spontaneous coronary artery dissection (SCAD) is a rare cause of acute coronary syndrome. It occurs predominantly among younger females and typically in the absence of atherosclerotic coronary artery disease. It is associated with peripartum period, connective tissue disorders, vasculitides, and extreme exertion. Presentations vary greatly, and this condition can be ...
Kochman Janusz J 1st Department of Cardiology, Warsaw Medical University, Poland. - - 2014
Bioresorbable vascular scaffold (BVS) implantation is a new, promising treatment method of coronary artery disease (CAD). Preliminary data in patients with stable angina is encouraging. However, the utility of BVS was not sufficiently evaluated in the setting of acute thrombotic lesions. The aim of this study was an optical coherence ...
Seremet Sila S Department of Dermatology, Izmir Katip Celebi University Ataturk Training and Research Hospital, Izmir, - - 2014
Associations have been recently recognized between psoriasis and an increased incidence of atherosclerotic diseases. However, there are scarce data on the prevalence of coronary lesions in patients with psoriasis. The aim of this study was to identify the calcified and non-calcified atherosclerotic coronary lesions in patients with psoriasis compared to ...
Fattouch Khalil K Khalil Fattouch, Department of Cardiovascular Surgery, GVM Care and Research, Maria Eleonora Hospital, 90100 Palermo, - - 2014
Ischemic mitral regurgitation (IMR) represents a common complication after myocardial infarction. The valve is anatomically normal and the incompetence is the result of papillary muscles displacement and annular dilatation, causing leaflets tethering. Functionally the leaflets present a restricted systolic motion due to tethering forces that displaces the coaptation surface toward ...
Saeed Maythem M Maythem Saeed, Steven W Hetts, Robert Jablonowski, Mark W Wilson, Department of Radiology and Biomedical Imaging, School of Medicine, University of California San Francisco, San Francisco, CA 94107-5705, United - - 2014
Myocardial pathologies are major causes of morbidity and mortality worldwide. Early detection of loss of cellular integrity and expansion in extracellular volume (ECV) in myocardium is critical to initiate effective treatment. The three compartments in healthy myocardium are: intravascular (approximately 10% of tissue volume), interstitium (approximately 15%) and intracellular (approximately ...
Ino Yasushi Y Department of Cardiovascular Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-8509, - - 2014
The long-term safety of second-generation everolimus-eluting stents (EESs) in ST-segment elevation myocardial infarction (STEMI) remains unclear. The aim of this study was to evaluate the late vascular response after stent implantation in STEMI between EES and bare-metal stent (BMS) by using optical coherence tomography (OCT). A prospective OCT examination was ...
Cho Sungsoo S Severance Cardiovascular Hospital, Yonsei University Health System, Seoul, - - 2014
Although the use of drug-eluting stents (DESs) in patients with coronary artery disease has contributed to a significant reduction in in-stent restenosis and repeat revascularization, treating diffuse long lesions using DESs remains challenging due to the high rates of in-stent restenosis and stent thrombosis. Intravascular ultrasound (IVUS) provides tomographic images ...
Nakata Kotaro K Division of Cardiology, Saitama Cardiovascular Respiratory Center, 1696 Itai, Kumagaya, Saitama, 360-3197, - - 2014
We performed a propensity score-matching comparison of the midterm clinical and angiographic outcomes after primary stenting between using bare-metal stents (BMSs) and sirolimus-eluting stent (SES; Cypher Bx Velocity) for ST-segment elevated myocardial infarction (STEMI), because, in the drug-eluting stent era, the indication of the BMSs when a large balloon diameter ...
Zhang Yao-Jun YJ Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands Nanjing Medical University, Nanjing First Hospital, Nanjing, - - 2014
To investigate clinical outcomes of coronary intervention using a biolimus-eluting stent (BES) compared with a sirolimus-eluting stent (SES) in patients with acute myocardial infarction (AMI) in the Limus Eluted from A Durable versus ERodable Stent (LEADERS) coating trial at the final 5-year follow-up. The LEADERS trial is a multicentre all-comer ...
Madder Ryan D RD Frederik Meijer Heart & Vascular Institute, Spectrum Health, Grand Rapids, - - 2014
Objective: This study was performed to assess the lipid burden of culprit lesions in non-ST-segment elevation myocardial infarction (non-STEMI) and unstable angina (UA). Background: A recent intracoronary near-infrared spectroscopy (NIRS) study showed 85% of STEMI culprit lesions have a maximum lipid core burden index in 4-mm (maxLCBI4mm ) ≥400. Whether ...
Hata Yukiko Y Department of Legal Medicine, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, - - 2014
The prognosis of patients in whom the right coronary artery (RCA) arises from the left coronary sinus (LCS) is unequal. An initial intramural course of the coronary artery within the aortic media is considered to cause myocardial ischemia in cases of coronary anomalies. Clinicopathological findings in five autopsy cases where ...
Dudzinski David M - - 2014
Ischemic mitral regurgitation is an important consequence of LV remodeling after myocardial infarction. Echocardiographic diagnosis and assessment of ischemic mitral regurgitation are critical to gauge its adverse effects on prognosis and to attempt to tailor rational treatment strategy. There is no single approach to the echocardiographic assessment of ischemic mitral ...
Kong Y-G YG Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, - - 2014
Coronary computed tomographic angiography (coronary CT) is a non-invasive test for diagnosis of cardiac function. Coronary calcium scores determined by coronary CT are associated with cardiovascular risk factors. However, no studies have investigated the association between coronary calcium scores and cardiovascular complications after liver transplantation (LT). We therefore evaluated the ...
Braber T L TL Department of Radiology, University Medical Center Utrecht, Utrecht, the Netherlands, - - 2014
More than 90 % of exercise-related cardiac arrests occur in men, predominantly those aged 45 years and older with coronary artery disease (CAD) as the main cause. The current sports medical evaluation (SME) of middle-aged recreational athletes consists of a medical history, physical examination, and resting and exercise electrocardiography. Coronary CT (CCT) ...
Witberg Guy G Department of Cardiology, Rabin Medical Center, PetachTikva, - - 2014
Objective: to broaden the data supporting the use of the residual SYNTAX score (rSS) to define 'reasonable' ICR in order to improve the allocation of patients with severe CAD to surgical/percutaneous revascularization and long-term clinical outcomes. Introduction: Incomplete coronary revascularization (ICR) is associated with a worse prognosis in patients with ...
Suzuki Akihiro A Department of Cardiology, Aichi Medical University, Nagakute, - - 2014
The aim of this study was to address the association of lipid profiles with periprocedural myocardial infarction (pMI) after elective percutaneous coronary intervention (PCI). Of the 302 consecutive patients who received elective PCI at the Chubu Rosai Hospital, Nagoya, Japan between June 2009 and December 2010, data from 231 native ...
Liu Yan Y Guangdong Provincial Key Laboratory of Food, Nutrition and Health, PR China; Department of Nutrition, School of Public Health, Sun Yat-sen University (Northern Campus), Guangzhou, Guangdong Province, PR - - 2014
Objectives: This study was to examine the association between plasma retinol binding protein 4 (RBP4) levels and the complexity of angiographic coronary lesion in patients with coronary artery disease (CAD). Methods and results: A cross-sectional and prospective study was carried out in Guangzhou Chinese population. 672 persons were evaluated by ...
Potekhina Alexandra V AV Russian Cardiology Research Center, 121552, 3rd Cherepkovskaya str. 15A, Moscow, Russia. Electronic address: - - 2014
Objective. Immune processes play a significant role in atherosclerosis plaque progression. Regulatory T cells and T helpers 17 were shown to possess anti- and pro-atherogenic activity, respectively. We aimed to investigate the balance of circulating Treg and Th17 in stable angina patients with different stages of coronary atherosclerosis. Methods. Treg, ...
Drenjancevic Ines I Faculty of Medicine University of Osijek, Department of Physiology and Immunology, Osijek, Croatia. Electronic address: - - 2014
Coronary blood flow closely matches to metabolic demands of heart and myocardial oxygen consumption and is conditioned by function of coronary resistance vessels. The microvascular endothelium of coronary resistance vessels is exposed to a spatially and temporally regulated input from cardiomyocytes and the haemodynamic forces of the cardiac cycle. Functional ...
Kaiser Christoph C Department of Cardiology, University Hospital, Basel, Switzerland - - 2014
-Biodegradable-polymer drug-eluting stents (BP-DES) were developed to be as effective as second-generation durable-polymer drug-eluting stents (DP-DES) and as safe >1 year as bare-metal stents (BMS). Thus, very late stent thrombosis (VLST) attributable to durable polymers should no longer appear. -To address these early and late aspects, 2291 patients presenting with ...
Tu Benny - - 2014
The optimal revascularization technique in diabetic patients is an important unresolved question. To compare long-term outcomes between the revascularization techniques of percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG). English-language publications in PubMed, the Cochrane Central Register of Controlled Trials, Ovid, and EMBASE between 1 January 1990 and ...
Goel Sachin S - - 2014
Data are lacking on the effect of renin-angiotensin system (RAS) blockade therapy with angiotensin-converting enzyme inhibitors or angiotensin-receptor blockers after surgical aortic valve replacement (SAVR) for severe aortic stenosis (AS). To investigate the association between RAS blockade therapy and outcomes after SAVR for severe AS. Retrospective study. Single tertiary referral ...
Tanabe Yasuhiro Y Division of Cardiology, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1, Sugao, Miyamae-ku, Kawasaki, Kanagawa, 216-8511, Japan, - - 2014
Microvascular angina is a rare condition in which myocardial ischemia is caused by microvascular dysfunction without any abnormalities of the epicardial coronary arteries. In clinical practice, it is difficult to diagnose because the microvascular alterations cannot be detected by conventional angiography. Herein we present a rare case of a 67-year-old ...
Tweet Marysia S MS From the Divisions of Cardiovascular Diseases (M.S.T., M.F.E., P.J.M.B., A.L., C.S.R., D.R.H., S.N.H., R.G.) and Biomedical Statistics and Informatics (R.J.L.), Mayo Clinic, Rochester, - - 2014
Spontaneous coronary artery dissection (SCAD) is a nonatherosclerotic acute coronary syndrome for which optimal management remains undefined. We performed a retrospective study of 189 patients presenting with a first SCAD episode. We evaluated outcomes according to initial management: (1) revascularization versus conservative therapy and (2) percutaneous coronary intervention (PCI) versus ...
Smith Peter K PK The authors' affiliations are listed in the - - 2014
Ischemic mitral regurgitation is associated with increased mortality and morbidity. For surgical patients with moderate regurgitation, the benefits of adding mitral-valve repair to coronary-artery bypass grafting (CABG) are uncertain. We randomly assigned 301 patients with moderate ischemic mitral regurgitation to CABG alone or CABG plus mitral-valve repair (combined procedure). The ...
Thakkar Jay B JB Department of Cardiology, Westmead Hospital, Sydney, NSW, Australia. - - 2014
Despite overwhelming evidence of the effectiveness of secondary prevention therapies, surveys indicate poor adherence to medical treatments and lifestyle recommendations after an acute coronary syndrome. The term adherence is preferred over compliance, as the former suggests a therapeutic alliance, whereas the latter reflects passive patient obedience. Poor adherence results from ...
Javanbakht Mehdi M Health Economics Research Unit,Institute of Applied Health Sciences,University of Aberdeen;Health Management and Economics Research Center,School of Health Management and Information Sciences,Iran University of Medical - - 2014
Objectives: The aim of this study was to evaluate cost effectiveness of coronary artery bypass graft (CABG) versus percutaneous coronary intervention (PCI) with stenting from Iran society perspective. Methods: A retrospective study was carried out to estimate the annual cost and health related quality of life (HRQoL) of 109 patients ...
Caballero Luis L Department of Cardiology, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, - - 2014
Paravalvular aortic regurgitation after transcatheter aortic valve implantation is associated with a hemodynamic deterioration and a poor outcome. We aim to determine the early hemodynamic effect of paravalvular aortic regurgitation in relation with the change in the left ventricle filling pattern and to assess their clinical outcome. 82 consecutive patients ...
Koch Christian C Department of Anesthesiology and Intensive Care Medicine, University Hospital of Giessen and Marburg, Giessen, - - 2014
Myeloperoxidase (MPO) plasma values predict major adverse cardiac events (MACE) in cases of acute coronary syndrome. The effect of serial testing in patients who are suspected for acute coronary ischemia is unclear. We hypothesize that sequential MPO measurement may improve prediction of MACE in patients with suspected acute coronary ischemia. ...
Taqueti Viviany R VR Noninvasive Cardiovascular Imaging Program, Heart and Vascular Institute, Division of Cardiovascular Medicine, Department of Medicine and Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, - - 2014
-Coronary flow reserve (CFR), an integrated measure of focal, diffuse and small vessel coronary artery disease (CAD), identifies patients at risk for cardiac death. We sought to determine the association between CFR, angiographic CAD, and cardiovascular outcomes. -Consecutive patients (n=329) referred for invasive coronary angiography after stress testing with myocardial ...
Schulman-Marcus Joshua J Department of Medicine, The NewYork-Presbyterian Hospital and the Weill Cornell Medical College, New York, NY, - - 2014
Objective: This study sought to determine the correlation between baseline cardiac medications and cardiovascular outcomes in patients with obstructive coronary artery disease (CAD) diagnosed by coronary computed tomographic angiography (CCTA). Methods: 1637 patients (mean age 64.8 ± 10.2 years, 69.6% male) with obstructive CAD from the CONFIRM (COronary CT Angiography EvaluatioN For ...
Grimm Joshua C JC Division of Vascular Surgery and Endovascular Therapy, Johns Hopkins Bayview Medical Center, Johns Hopkins Hospital, Baltimore, - - 2014
While the Carotid Revascularization Endarterectomy Versus Stenting Trial (CREST) has been widely accepted as a landmark trial establishing an equivalent risk of major adverse events following carotid endarterectomy (CEA) or carotid artery stenting (CAS), the applicability of these findings to single centers has been questioned owing to the rigid selection ...
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