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Rassi Andrew N AN Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, - - 2014
Aortic stenosis (AS) is a progressive condition associated with high mortality if not treated. The hemodynamic effects of AS have serious implications for the left ventricle. In this review, we describe the responses of the left ventricle to AS by highlighting the process of adaptive remodelling, which begins as a ...
Bergler-Klein Jutta J Department of Cardiology, University Clinic of Internal Medicine II, Medical University of Vienna, Vienna, Austria. Electronic address: - - 2014
The optimal timing of valve surgery remains controversial. Biomarkers can be serially monitored and are objective laboratory measurements. Plasma B-type natriuretic peptide (BNP) and its N-terminal pro-form are well known predictors in heart failure. Diastolic stretch induces cardiomyocyte BNP expression in volume-loaded conditions like aortic or mitral regurgitation (MR) or ...
Pokorny Saskia S Department of Cardiovascular Surgery, Christian-Albrechts-University of Kiel, School of Medicine, Kiel, - - 2014
Aims: The evaluation of in vivo shaping of mitral valved stent prototypes using cardiac computed tomography (CT) was the focus of this study. Methods and results: Twelve pigs received a self-expanding mitral valved stent, composed of an atrial element connected to a tubular ventricular body at a modified angle (45°, ...
Athyros Vasilios G VG Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippocrates Hospital, Thessaloniki, - - 2014
Abstract Administration of high intensity statins prior to percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) or stable coronary artery disease has been shown to reduce short-, mid, and long-term cardiovascular disease (CVD) morbidity and mortality as well as overall mortality compared with lower intensity statins or no statin ...
Paarup Dridi Nadia N Department of Cardiology, The Heart Centre , Rigshosptalet , Denmark - - 2014
Abstract Aim: To investigate whether an intensified antiplatelet regimen could improve prognosis in stable or non-ST elevation in acute coronary syndrome (ACS) patients exhibiting high on-treatment platelet reactivity (HTPR) on clopidogrel and treated with percutaneous coronary intervention (PCI). There is a wide variability in the platelet reactivity to clopidogrel and ...
Chin Calvin W L CW British Heart Foundation/University Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom & National Heart Center Singapore, Singapore - - 2014
-Electrocardiographic (ECG) left ventricular hypertrophy (LVH) with strain is associated with an adverse prognosis in aortic stenosis. We investigated the mechanisms and outcomes associated with ECG-strain. -One hundred and two patients (70 [63,75] years, 66% males, aortic valve area 0.9 [0.7,1.2] cm(2)) underwent ECG, echocardiography and cardiovascular magnetic resonance: the ...
Michael Tesfaldet T TT Knight Cardiovascular Institute, Oregon Health & Science University, Portland, - - 2014
To compare long-term clinical outcomes of chronic total occlusion (CTO) percutaneous coronary intervention (PCI) using the retrograde and antegrade approach. There is limited long-term clinical outcomes data on the retrograde approach to CTO PCI. We performed a retrospective analysis of the long-term clinical outcomes of 193 consecutive patients who underwent ...
Lee Seung-Yul SY Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, - - 2014
Objectives: We evaluated whether morphological characteristics of neointimal tissue of in-stent restenosis (ISR) lesions assessed by optical coherence tomography (OCT) affect peri-procedural elevation of creatine kinase-myocardial band (CK-MB). Background: The impact of neointimal characteristics of ISR lesions on peri-procedural myocardial injury has not been sufficiently investigated. Methods: A total of ...
Klug Gert G University Clinic of Internal Medicine III, Cardiology, Innsbruck Medical University, Anichstraße 35, A-6020 Innsbruck, - - 2014
Cardiac magnetic resonance (CMR) is a unique method to determine regional and local aortic stiffness parameters. Although various methods have been validated, there is no data in patients after acute ST-segment elevation myocardial infarction (STEMI). In the present study we assessed the feasibility of different CMR derived measures of aortic ...
Jiang Fangyong F Department of Cardiology, Liuzhou People's Hospital, Liuzhou, Guangxi, - - 2014
Statins reduce the incidence of cardiovascular events after percutaneous coronary intervention (PCI), but no clinical studies have investigated the role of statins in ischemia-reperfusion injury after PCI. Rosuvastatin could reduce ischemia-reperfusion injury in patients with acute coronary syndrome treated with PCI. We investigated the effects of rosuvastatin on ischemia-reperfusion injury ...
Lamberts Morten M aDepartment of Cardiology, Gentofte University Hospital, Hellerup, Copenhagen, Denmark bDepartment of Cardiology, Amphia Hospital, Breda, the - - 2014
The optimal antithrombotic therapy in patients with atrial fibrillation and coronary artery disease is controversial. The benefit of the combination of antithrombotic therapies remains debatable, and, as the bleeding risk is substantial, this calls for knowledge of the duration, and which and how many agents should be used. The first ...
Lambadiari Vaia - - 2014
BackgroundThe interplay between the novel adipokine retinol-binding protein-4 (RBP4) and coronary artery disease (CAD) is still obscure. We investigated the relationship between RBP4 levels and the presence and severity of angiographically proven CAD and determined its possible role in acute myocardial infarction (AMI).Methods305 individuals with angiographically proven CAD (CAD-patients), were ...
Salminen Pirjo-Riitta PR Department of Heart Disease, Haukeland University Hospital, Bergen, Norway Department of Clinical Science, Faculty of Medicine and Dentistry, University of Bergen, Norway - - 2014
Experimental studies have demonstrated that insulin elicits cardioprotection in coronary occlusion-reperfusion models. We studied the effects of intracoronary insulin on regional cardiac function in a porcine model with reperfusion after a critical coronary artery stenosis. In 20 anaesthetized pigs with an extracorporeal shunt from the brachiocephalic to the left anterior ...
Rischin Adam P AP Department of Cardiology, Frankston Hospital, Peninsula Health, Frankston, Victoria, Australia. Electronic address: - - 2014
We present the case of a 42 year-old woman admitted to hospital with ST-elevation myocardial infarction involving two separate coronary territories. Angiography revealed multi-embolic occlusions of her left anterior descending (LAD) and first obtuse marginal (OM1) coronary arteries. Transoesophageal echocardiogram (TOE) showed a lesion attached to the left cusp of ...
Di Lorenzo Emilio E Division of Cardiology, "S.G. Moscati", Avellino, - - 2014
The aim of the current study was to compare everolimus-eluting stents (EES) with sirolimus-eluting stents (SES) in patients undergoing primary angioplasty. Drug-eluting stents may offer benefits in terms of repeat revascularization. However, as shown for first-generation drug-eluting stents, they may be counterbalanced by a potential higher risk of stent thrombosis, ...
Abu-Laban Riyad B - - 2014
ABSTRACTExtracorporeal membrane oxygenation (ECMO) is a method to provide temporary cardiac and respiratory support to critically ill patients. In recent years, the role of ECMO in emergency departments (EDs) for select adults has increased. We present the dramatic case of a 29-year-old man who was placed on venoarterial ECMO for ...
Seadon Scott - - 2014
Clinical questionFollowing transient ischemic attack or acute minor stroke, does the combination of clopidogrel and aspirin reduce the risk of stroke greater than aspirin alone?Article chosenWang Y, Wang Y, Zhao X, et al. Clopidogrel with aspirin in acute minor stroke or transient ischemic attack. N Engl J Med 2013;369:11-9.ObjectiveThe primary ...
Nobre Christiane A - - 2014
Smoking is a risk factor for thromboangiitis obliterans (TAO, Buerger's disease) and arteriosclerosis, but there are few cases of coronary heart disease (CAD)-associated Buerger's disease. A literature search for articles in English, Spanish and French published between 1966 and 2012 on patients with coronary involvement and TAO revealed 12 patients. ...
Thomson Viji S VS Consultant Cardiologist, Department of Medicine, Sultan Qaboos University Hospital, Al Khoud, Muscat, PB: 35 PC: 123, Muscat, Sultanate of - - 2014
Multivessel coronary spasm resulting to cardiogenic shock and malignant ventricular arrhythmias though rare has been reported in the literature. The disease seems to be more prevalent in Asians. There have been isolated reports of coronary spasm in patients with reactive airway disease. We report the first case of spontaneous multivessel ...
Sivalingam Sivakumar S Department of Cardiothoracic Surgery, National Heart Institute, Kuala Lumpur, Malaysia - - 2014
A 9-year-old boy was referred with a perimembranous ventricular septal defect. At birth, he had undergone a right thoracotomy with ligation of a tracheoesophageal fistula, cervical esophagostomy, and feeding gastrostomy. At 2 years of age, he had gastric tube reconstruction with a pull-through retrosternally, anterior to the heart, and an ...
Schwerg Marius M Department of Cardiology and Angiology, Charité - Universitätsmedizin, Berlin, - - 2014
Postoperative lead perforation is a life-threatening complication of cardiac pacing. Identification of precipitating factors for this serious complication may help to anticipate a specific risk profile and to minimize the incidence. We conducted a retrospective tertiary referral center analysis to clarify clinical, anatomical, and technical characteristics related to pacemaker (PM) ...
Sharif Hamid H Department of Cardiology, Armed Forces Institute of Cardiology, National Institute of Heart Diseases, - - 2014
Myocardial perforation (MP) is an uncommon entity which occurs most commonly in the setting of acute myocardial infarction. We report a case of accidental left ventricular perforation during a routine coronary angiogram. A 55-year-old male, known diabetic with moderate renal impairment, non-hypertensive, suffered an acute inferior wall myocardial infarction for ...
Kim Bum Joon BJ Department of Neurology, Asan Medical Center, Seoul, - - 2014
Perforator infarction accompanying intracranial atherosclerosis is usually explained by the obstruction of perforator by atheroma of the parent artery. However, the improvement of neurologic symptom after stenting is hardly explained by the concept. Here, we report a case of perforator infarction caused by the unique hemodynamic condition of the poststenotic ...
Kuk Mariya M From the Department of Pathology and Toxicology, Schulich School of Medicine and Dentistry (M.K.), Department of Psychiatry (V.B.), Imaging Research Group, Robarts Research Institute (G.P., A.F., J.D.S.), and Stroke Prevention and Atherosclerosis Research Centre, Robarts Research Institute (J.D.S.), Western University, London, Ontario, Canada; and Department of Internal Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand - - 2014
Previous studies have shown the presence of ulceration in atherosclerotic plaque either by categorizing the plaque as complex (irregular morphology with ulcers) or smooth or by quantifying the number of ulcers observed in a specific region of interest. The aim of this study was to quantify carotid total ulcer volume ...
Wu Jin-Tao JT Department of Cardiology, Henan Provincial People's Hospital, Zhengzhou University, Zhengzhou, - - 2014
Cardiac perforation during catheter-based radiofrequency ablation procedures is relatively uncommon but potentially fatal if tamponade ensues. This complication should be promptly recognised. We present a case of incomplete perforation of the left ventricle with transient ST-segment elevation in leads V1 to V3 during catheter ablation of ventricular tachycardia. Complete perforation ...
Abe Arata A Department of Neurological Science, Graduate School of Medicine, Nippon Medical - - 2014
A 75-year-old man was admitted to our hospital with dysphagia shortly after the onset of a brainstem infarction. Videofluorography indicated the presence of a Zenker's diverticulum with a bolus at the esophageal orifice; endoscopy 5 years earlier had not shown a Zenker's diverticulum and suggests that the diverticulum had formed ...
McManus Kenneth K Department of Emergency Medicine, Naval Medical Center Portsmouth, Portsmouth, Virginia, - - 2014
An 83-year-old man 2 days postoperative from L3 to L5 laminectomy developed sudden onset of chest pain. Initial ECGs demonstrated a tall R wave in V1 and ST-segment depression in leads V2-V5. A posterior ECG was performed, but failed to demonstrate ST elevations. The patient was initially treated as an non-ST-segment ...
Echeverría Patricia P "Lluita contra la Sida" Foundation, Hospital Universitari Germans Trias i Pujol, Badalona, 08916 Barcelona, Spain ; Universitat Autònoma de Barcelona, Barcelona, - - 2014
Background. There are conflicting data on the prevalence of coronary events and the quality of the management of modifiable cardiovascular risk factors (CVRF) in HIV-infected patients. Methods. We performed a retrospective descriptive study to determine the prevalence of coronary events and to evaluate the management of CVRF in a Mediterranean ...
Köksal Aydin S - - 2013
Recent guidelines and consensus reports recommend endoscopic injection therapy with N-butyl-2-cyanoacrylate as the first-line treatment for bleeding-isolated gastric varices and gastroesophageal varices types 1 and 2. Embolization is a rare but serious complication of cyanoacrylate injection, which may be fatal in some cases. Herein, we present a patient who developed ...
Wallace Eric L - - 2013
To characterize the perfusion bed of the first septal perforator by myocardial contrast echocardiography (MCE) in patients with hypertrophic cardiomyopathy undergoing alcohol septal ablation (ASA). MCE is used to define the septal perforator anatomy prior to ASA. Occasionally, ASA cannot be performed due to unfavorable septal anatomy or perfusion outside ...
Rennyson Stephen L - - 2013
Left ventricular support devices (LVADs) are associated with a propensity toward gastrointestinal bleeding. A postulated mechanism is related to gastrointestinal arteriovenous malformations secondary to nonpulsatile flow. We describe a case of LVAD-related, gastrointestinal bleeding successfully treated with a combination of subcutaneous and intramuscular depot formulations of octreotide.
Kim Dongmin - - 2013
Chest draining is a common procedure for treating pleural effusion. Perforation of the heart is a rare often fatal complication of chest drain insertion. We report a case of a 76-year-old female patient suffering from congestive heart failure. At presentation, unilateral opacity of the left chest observed on a chest ...
Strauss David G - - 2013
OBJECTIVES: To test the hypothesis that right bundle branch block (RBBB) patients have larger scar size than left bundle branch block (LBBB) patients. BACKGROUND: A proximal septal perforating branch of the left anterior descending (LAD) coronary artery most commonly perfuses the right bundle branch and left anterior fascicle, but not ...
Sallam Tamer - - 2013
Our patient underwent emergent CABG after suffering a coronary perforation during PCI and subsequently developed two large coronary pseudoaneurysms which were treated with a percutaneous approach using feathered coils. The incidence of emergency CABG secondary to perforation has dramatically decreased [1] however, the mortality for emergent CABG remains extremely high ...
Singh Yadvinder - - 2013
A previously healthy 16-year-old girl presented with history of fever of 3 months duration without any significant clinical finding on examination. Transthoracic echocardiography (TTE) revealed moderate pericardial effusion and later diagnosed as tubercular in etiology. Besides, TTE also showed an incidental finding of large left ventricular (LV) diverticulum in submitral region ...
Pojar Marek - - 2013
Cardiac ventricle perforation by a pacemaker (PM) lead is an uncommon complication of PM implantation. We report a patient with a delayed right ventricular perforation from a permanent PM lead which presented as a left hemothorax.
Alston Evan A EA Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294-0019, - - 2013
Covered stents are the standard of care when coronary perforations complicate percutaneous coronary interventions and have also been utilized in the treatment of coronary aneurysms. We present the clinical and histologic features of a patient who developed a coronary perforation and pseudoaneurysm 4 years following deployment of intracoronary stents. Although ...
Chen Dong-Yi - - 2013
Percutaneous coronary intervention carries the risk of coronary artery perforation, which may lead to serious adverse effects such as cardiac tamponade, myocardial infarction, and even death. We describe a patient who developed hemoptysis immediately after saphenous vein graft rupture, which is a rare complication during coronary intervention. Stenting using a ...
Garg Kanwaljeet - - 2012
Ventricular diverticula are dilatations of the ventricular system caused by stretching and protrusion of the ventricular wall as a result of severe chronic obstructive hydrocephalus. We report a case of lateral ventricular diverticulum arising from the occipital horn in a patient with occipital encephalocele. To the best of our knowledge, ...
Nagel Bert - - 2012
This case report describes a unique form of a left ventricular diverticulum in a 17-year-old patient.Echocardiography, angiography, and magnetic resonance imaging including virtual endoscopy complete a detailed picture of the size and texture of a diverticulum, as well as the localisation of the two connections into the left ventricle.
Alves Marco G - - 2012
ABSTRACT:: Understanding heart metabolism during preservation is crucial to develop new effective cardioplegic solutions. We aim to investigate metabolic alterations during heart preservation in the clinically used Celsior (Cs) and histidine buffer solution (HBS). We also focused in gender-specific metabolic adaptations during ischemia. We followed energy metabolism in hearts from ...
Guglin Maya - - 2012
Objectives: The dataset from the Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness (ESCAPE) trial provides a rare opportunity to evaluate the whole spectrum of associations of hemoglobin (HB) and hematocrit (HCT) in heart failure (HF). In that trial, subjective and objective data were recorded at multiple ...
Kalra Paul R - - 2012
AIMS: The present study aims to investigate patterns of beta-blocker usage in a national primary care cohort. METHODS AND RESULTS: This is a retrospective cohort study utilising the UK General Practice Research Database from 2004 to 2008. Inclusion criteria were (i) a first diagnosis of chronic heart failure (CHF), myocardial ...
Chen Zhangwei - - 2012
OBJECTIVES: This study was designed to evidence the protective effect of glucocorticoid therapy on cardiac dysfunction after coronary microembolization (CME), and to clarify its mechanism with the expression of transforming growth factor-beta 1 (TGF-β1)/Smad3 and connective tissue growth factor (CTGF). METHODS: Eighteen mini-pigs were studied, including Sham-operation group (n=4), CME ...
Trost Jeffrey C - - 2012
: Familiarize clinicians with recent information regarding the diagnosis and treatment of ST-segment elevation myocardial infarction. : PubMed search and review of relevant medical literature. : Definition, pathophysiology, clinical presentation, diagnosis, and treatment of ST-segment elevation myocardial infarction are reviewed. : Patients with ST-segment elevation myocardial infarction benefit from prompt ...
Ivanović Branislava - - 2012
Peripartum cardiomyopathy is a life threatening condition of unknown cause that occurs in previously healthy women. It is characterized by symptoms of heart failure due to left ventricular dysfunction that occurs in the last month of pregnancy or the first five months after delivery. We presented woman who underwent caesarean ...
Cowie Martin R MR Imperial College London (Roya Brompton Hospital), London, - - 2012
The typical presentation of heart failure in primary care is insidious, with progressive breathlessness on exertion, ankle swelling, orthopnoea or paroxysmal nocturnal dyspnoea. Not all patients will have all these symptoms, and in many patients there may be other causes. If a GP suspects heart failure, then the key blood ...
Gajzer David C - - 2012
Epicardial resident stem cells are known to differentiate into cardiomyocytes during cardiac development, amongst other cell types. Whether epicardium-derived progenitor cells (EPDCs) retain this plasticity in the adult heart has been the topic of heated scientific debate. Priming with thymosin beta 4, a peptide which has been suggested to be ...
Maggio Aurelio - - 2012
A multicenter randomized open-label long-term sequential deferiprone–deferoxamine (DFP-DFO) versus DFP alone trial (sequential DFP-DFO) performed in patients with thalassemia major (TM) was retrospectively reanalyzed to assess the variation in the left ventricular ejection fraction (LVEF) [1].
Komatsu Yuki - - 2012
AIM: The objective is to assess electrocardiographic characteristics predicting the precise location of ventricular arrhythmia (VA) origin within the right ventricle (RV) close to the His bundle (HB) region.METHODS AND RESULTS: Twenty-five patients (14 men, age 65 ± 14 years) underwent successful catheter ablation of para-Hisian VA. Ventricular arrhythmias were ...
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