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Results 201 - 250 of 2524
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Tricoci Pierluigi P Duke Clinical Research Institute, Durham NC. Electronic address: - - 2014
Protease-activated receptor 1 antagonism with vorapaxar represents a novel strategy for platelet inhibition. In TRACER, vorapaxar was compared with placebo plus standard of care among 12,944 patients with non-ST-segment elevation acute coronary syndromes. We anticipated that most patients would have received clopidogrel as part of standard care. We investigated the ...
Reiff T T Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany. Electronic address: - - 2014
In primary and secondary prevention, statins significantly reduce cardiovascular and cerebrovascular events. Pre-interventional statin medication shows a benefit in carotid artery stenosis patients treated with endarterectomy; however, there are few data available for patients treated with stent-angioplasty. The aim of this study was to investigate whether pre-interventional statin therapy is ...
Wang Jiangang J Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China - - 2014
This study aimed to evaluate risk factors that affect mitral valve (MV) repair outcomes. From 2002 to 2012, 580 consecutive patients with mitral regurgitation (MR) underwent MV repair. Of the total number of patients, 48.9% were found to be in New York Heart Association (NYHA) Class III or IV. Anterior, ...
Marmelo Filipe Carvalho FC Escola Superior de Saúde Dr. Lopes Dias, - - 2014
Background: Aortic valve sclerosis (AVS) is characterized by increased thickness, calcification and stiffness of the aortic leaflets without fusion of the commissures. Several studies show an association between AVS and presence of coronary artery disease. Objective: The aim of this study is to investigate the association between presence of AVS ...
Puri Rishi R From the Department of Cardiovascular Medicine (R.P., S.E.N.) C5Research (R.P., M.S., S.J.N.), Cleveland Clinic, OH; Section of Cardiovascular Research, Baylor College of Medicine, and the Methodist DeBakey Heart and Vascular Center, Houston, TX (C.M.B.); Centre for Vascular Research, University of New South Wales, Sydney, New South Wales, Australia (P.J.B.); INSERM Dyslipidaemia and Atherosclerosis Research Unit, Pitié-Salpetriere University Hospital, Paris, France (M.J.C.); West German Heart Center, Essen, Germany (R.E.); Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (P.L.); AstraZeneca, Wilmington, Delaware (J.S.R.); and South Australian Health and Medical Research Institute, University of Adelaide, Adelaide, South Australia, Australia (K.U., Y.K., - - 2014
Patients with acute coronary syndromes (ACS) display diffuse coronary atheroma instability and heightened risk of early and late recurrent coronary events. We compared the long-term antiatherosclerotic efficacy of high-intensity statins in patients with ACS when compared with stable disease. Study of Coronary Atheroma by Intravascular Ultrasound: Effect of Rosuvastatin Versus ...
Messas Nathan N Pôle d'activité médico-chirurgicale cardiovasculaire, université de Strasbourg, Nouvel hôpital civil, BP 426, 67091 Strasbourg, - - 2014
In STEMI patients treated by primary PCI, damage of the microvascular circulation caused by distal embolization of thrombotic material affects the quality of myocardial reperfusion. Important controversies remain concerning the usefulness of the manual thrombectomy to improve myocardial perfusion. The aim of this study is to evaluate the impact of ...
Takahashi Shirushi S Department of Forensic Medicine, Saitama Medical University, 38 Morohongo, Moroyama-machi, Iruma-gun, Saitama, Japan. Electronic address: - - 2014
An eight-year-old Japanese boy developed abdominal pain, followed by convulsion and loss of consciousness. He was taken to an emergency room but could not be resuscitated. At autopsy, the left main coronary trunk (LMT) demonstrated an increase in caliber with severe luminal narrowing, and the left anterior descending branch (LAD) ...
Chang Tara I TI Stanford University School of Medicine, Stanford, - - 2014
Acute kidney injury (AKI) is a known complication after coronary revascularization, but few studies have directly compared the incidence of AKI after coronary artery bypass surgery (CABG) or after percutaneous coronary intervention (PCI) in similar patients. The aim of this study was to investigate whether multivessel CABG compared with PCI ...
Rinta-Kiikka Irina I Department of Clinical Radiology, Tampere University Hospital, - - 2014
Patients with acute ST-elevation myocardial infarction (STEMI) benefit substantially from emergent coronary reperfusion. The principal mechanism is to open the occluded coronary artery to minimize myocardial injury. Thus the size of the area at risk is a critical determinant of the patient outcome, although other factors, such as reperfusion injury, ...
Pastormerlo Luigi Emilio LE Division of Interventional Cardiology, Fondazione G. Monasterio CNR-Regione Toscana, Pisa-Massa, - - 2014
This study aimed to evaluate safety and efficacy of drug-coated balloon (DCB) at long-term follow-up; a large series of real-life patients underwent revascularization with DCB for a wide spectrum of clinical and angiographic situations. One hundred ten patients underwent percutaneous revascularization using paclitaxel eluting balloon (Sequent Please, Braun, Germany). End-points ...
Chai Qing Q Department of Critical Medicine and Anesthesiology, West China Hospital, Sichuan University, Chengdu, - - 2014
Remote ischaemia preconditioning (RIPC) induces some protection against heart ischaemia/reperfusion (IR) injury. However, many different methods were tried in the past, and no consensus exists. The aim of this study was to compare femoral and aortic ischaemia preconditioning on cardiac markers and on heart injury after IR. Sixty male Sprague-Dawley ...
Milano Carmelo C From the Duke University Medical Center, Durham, NC (C.M.); University of Michigan Medical Center, Ann Arbor (F.D.P., K.D.A.); University of Louisville, KY (M.S.S.); Tufts University School of Medicine, Boston, MA (D.T.P.); and HeartWare, Inc, Framingham, MA (D.R.H., M.V.J., K.B.N.). - - 2014
Cardiac valve procedures are commonly performed concurrently during implantation of left ventricular assist devices, but the added procedural risk has not been studied in detail. Data from patients receiving the HeartWare Ventricular Assist Device in the ADVANCE bridge to transplant (BTT) trial and continued access protocol were reviewed. Of 382 ...
Li Xiao-Hong XH Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, - - 2014
A 76-year-old man under stable hemodynamic condition was admitted to our hospital for delayed percutaneous coronary intervention following a diagnosis of acute inferior myocardial infarction. Bedside echocardiography revealed ventricular septal rupture at the basal posteroinferior wall with a large left-to-right shunt. Right ventricular free-wall intramyocardial dissection and tricuspid chordae rupture ...
Fanari Zaher Z Section of Cardiology, Christiana Care Health System, Newark, - - 2014
Comparing outcomes of percutaneous coronary intervention (PCI) with drug eluting stent (DES) and Coronary Artery Bypass Grafting (CABG) in patients with multivessel Coronary Artery Disease (CAD) using data from randomized controlled trials (RCT). PCI and CABG are established strategies for coronary revascularization in the setting of ischemic heart disease. Multiple ...
Higami Hirooki H Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, - - 2014
Previous studies reporting long-term (≥5 year) clinical outcome in patients with unprotected left main coronary artery (LMCA) disease undergoing drug-eluting stent (DES) implantation are currently limited, although late adverse events beyond 1 year are one of the major concerns of DES. We evaluated long-term clinical outcomes in 134 consecutive patients who underwent ...
Waksman Ron R MedStar Washington Hospital Center, Washington, DC. Electronic address: - - 2014
The aim of this study was to identify clinical, procedural, and angiographic correlates of late/very late drug-eluting stent (DES) thrombosis as well as to determine the clinical outcomes of these events. Late/very late DES thromboses are a poorly studied phenomenon, partly due to the relative infrequency of these events, even ...
Villwock Mark R MR Department of Neurosurgery, State University of New York Upstate Medical University, Syracuse, New - - 2014
The factors influencing outcomes after emergent admission for symptomatic carotid artery stenosis treated with revascularization by endarterectomy or stenting are yet to be fully elucidated. We analyzed revascularization of carotid artery stenosis for patients admitted emergently using the Nationwide Inpatient Sample (2008-2011). Admission characteristics, economic measures, in-hospital mortality, and iatrogenic ...
Elbarouni Basem B Terrence Donnelly Heart Centre, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada; St Boniface General Hospital, University of Manitoba, Winnipeg, Manitoba, - - 2014
A strategy of early transfer for coronary angiography and intervention is superior to a standard approach of delayed coronary angiography after fibrinolysis for ST-elevation myocardial infarction (STEMI). STEMI patients with lesions in noninfarct-related arteries have a worse prognosis compared with patients with single vessel disease. This study aimed to assess ...
Fanari Zaher Z Division of Cardiology, Christiana Care Health System, Newark, DE, USA - - 2014
Coronary artery bypass grafting (CABG) was found to be the preferred strategy of revascularization in patients with diabetes in the bare-metal stent (BMS) era. The introduction of drug-eluting stents (DESs) led to a significant reduction in the rates of repeat revascularization (RRV) when compared with BMSs. We did a collaborative ...
Safarova Maya S MS Atherosclerosis Department, Russian Cardiology Research and Production Center, Moscow, - - 2014
Lipoprotein(a) [Lp(a)] is acknowledged to be an independent atherothrombotic risk factor. Although genetic studies have highlighted the causal relationship between coronary disease and Lp(a), it is uncertain which strategies maximize the therapeutic benefit of patients with high Lp(a) levels. We report the challenging case of a young coronary heart disease ...
Wijeysundera Harindra C HC From the Schulich Heart Centre, Division of Cardiology, Sunnybrook Health Sciences Centre (H.C.W, M.C.B., D.T.K.) and Institute of Health Policy, Management, and Evaluation (H.C.W., D.T.K.), University of Toronto, Toronto, Ontario, Canada; Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada (H.C.W., F.Q., D.T.K.); Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Ontario, Canada (H.C.W.); Hamilton Health Sciences Centre, Hamilton, Ontario, Canada (M.K.N.); Southlake Regional Health Centre, Newmarket, Ontario, Canada (W.J.C.); St Mary's Hospital, Kitchener, Ontario, Canada (S.S.); and Cardiac Care Network of Ontario, North York, Ontario, Canada (K.J.K.). - - 2014
Wide variation exists in the detection rate of obstructive coronary artery disease (CAD) with elective coronary angiography for suspected stable ischemic heart disease. We sought to understand the incremental impact of nonclinical factors on this variation. We included all patients who underwent coronary angiography for possible suspected stable ischemic heart ...
Räber Lorenz L Department of Cardiology, Bern University Hospital, 3010, Bern, - - 2014
The effect of long-term high-intensity statin therapy on coronary atherosclerosis among patients with acute ST-segment elevation myocardial infarction (STEMI) is unknown. The aim of this study was to quantify the impact of high-intensity statin therapy on plaque burden, composition, and phenotype in non-infarct-related arteries of STEMI patients undergoing primary percutaneous ...
Rassi Andrew N AN Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, - - 2014
Aortic stenosis (AS) is a progressive condition associated with high mortality if not treated. The hemodynamic effects of AS have serious implications for the left ventricle. In this review, we describe the responses of the left ventricle to AS by highlighting the process of adaptive remodelling, which begins as a ...
Bergler-Klein Jutta J Department of Cardiology, University Clinic of Internal Medicine II, Medical University of Vienna, Vienna, Austria. Electronic address: - - 2014
The optimal timing of valve surgery remains controversial. Biomarkers can be serially monitored and are objective laboratory measurements. Plasma B-type natriuretic peptide (BNP) and its N-terminal pro-form are well known predictors in heart failure. Diastolic stretch induces cardiomyocyte BNP expression in volume-loaded conditions like aortic or mitral regurgitation (MR) or ...
Lagerqvist Bo B From the Department of Medical Sciences, Cardiology Section, and Uppsala Clinical Research Center, Uppsala University, Uppsala (B.L., O.O., S.K.J.), Department of Cardiology, Örebro University Hospital, Örebro (O.F., F.C.), Department of Coronary Heart Disease, Skane University Hospital, Clinical Sciences Section, Lund University, Lund (G.K.O., M.G., A.L.), Department of Cardiology, Karolinska Institutet, Södersjukhuset (P.A., O.C.), and Department of Cardiology, Karolinska Institutet, Danderyd (R.L.), Stockholm, Department of Cardiology, Umeå University Hospital, Umeå (J.A.), Section of Cardiology, Kalmar County Hospital and Linnaeus University, Kalmar (J.C.), Department of Cardiology, Halmstad Hospital, Halmstad (P.H.), Department of Cardiology, Sahlgrenska University Hospital, Gothenburg (D.I., J.O., E.O.), Department of Cardiology, Skaraborgs Hospital, Skövde (A.K.), Department of Radiology, Ryhov Hospital, Jönköping (V.P.), Department of Cardiology, Linköping University Hospital, Linköping (T.T.), and Department of Radiology, Mälarsjukhuset, Eskilstuna (E.Z.) - all in Sweden; Department of Cardiology and Cardiovascular Research Center, Landspitali University Hospital, Reykjavik, Iceland (T.G.); and the Department of Cardiology, Aarhus University Hospital, Skejby, Aarhus, Denmark - - 2014
Background Routine intracoronary thrombus aspiration before primary percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI) has not been proved to reduce short-term mortality. We evaluated clinical outcomes at 1 year after thrombus aspiration. Methods We randomly assigned 7244 patients with STEMI to undergo manual thrombus aspiration ...
Montalescot Gilles G The authors' affiliations are listed in the - - 2014
Background The direct-acting platelet P2Y12 receptor antagonist ticagrelor can reduce the incidence of major adverse cardiovascular events when administered at hospital admission to patients with ST-segment elevation myocardial infarction (STEMI). Whether prehospital administration of ticagrelor can improve coronary reperfusion and the clinical outcome is unknown. Methods We conducted an international, ...
Rade Jeffrey J JJ From the University of Massachusetts Medical School, - - 2014
Treatment strategies for patients with stable coronary artery disease are driven by the principles of reducing symptoms of coronary insufficiency, preventing myocardial infarction, and prolonging survival. Although percutaneous coronary intervention (PCI) plays a primary role in treating acute coronary syndromes, current guidelines relegate it largely to a secondary role in ...
Denault André Y AY Department of Anesthesiology, and Division of Critical Care, Montreal Heart Institute, Université de Montréal, Canada Division of Critical Care, Centre Hospitalier de l'Université de Montréal, Canada - - 2014
Amiodarone is commonly used in the acute care setting. However the acute hemodynamic and echocardiographic effect of intravenous amiodarone administered intraoperatively on right ventricular (RV) systolic and diastolic function using transesophageal echocardiography (TEE) has not been described. The study design was a randomized controlled trial in elective cardiac surgical patients ...
Atar Dan D Department of Cardiology B, Oslo University Hospital Ullevål, and Faculty of Medicine, University of Oslo, Oslo, Norway - - 2014
The MITOCARE study evaluated the efficacy and safety of TRO40303 for the reduction of reperfusion injury in patients undergoing revascularization for ST-elevation myocardial infarction (STEMI). Patients presenting with STEMI within 6 h of the onset of pain randomly received TRO40303 (n = 83) or placebo (n = 80) via i.v. ...
Kumar Sanjay S Cardiac Catheterization and Interventional Cardiology, SUNY Downstate Medical Center, 450 Clarkson Avenue, Box 1257, Brooklyn, NY 11203- 2098 USA. - - 2014
Each year, over 1 million percutaneous coronary interventions (PCIs) are performed in the United States. Coronary stents have been shown to reduce restenosis or abrupt vessel closure and therefore have improved the success of PCI. Rarely, manufacturers recall stents due to unanticipated problems. We sought to study the extent and ...
Yıldız Esra E Clinic of Internal Medicine, Okmeydanı Education and Research Hospital; İstanbul-Turkey. - - 2014
Patients may develop kidney failure because of the contrast agent given during coronary angiography. Renal dysfunction and heart failure were previously shown to be associated with the development of contrast nephropathy. In our study, we aimed to investigate whether there is a relationship between subclinical renal (indicated by microalbuminuria) and/or ...
Bal Uğur Abbas UA Department of Cardiology, Faculty of Medicine, Başkent University; Ankara-Turkey. - - 2014
The aim of this study was to investigate the factors associated with coronary stent restenosis and if there is an association between plasma asymmetric dimethylarginine (ADMA) levels and stent restenosis. Ninety-one patients, who had a history of coronary bare metal stent implantation due to any cause in the last one ...
Thompson Peter L PL Heart Research Institute, Sir Charles Gairdner Hospital and University of Western Australia, Perth, Western Australia, Australia. Electronic address: - - 2014
Atrial fibrillation (AF) and coronary heart disease (CHD) commonly occur together. Previous consensus guidelines were published before the wide availability of novel oral anticoagulants (NOACs) and newer P2Y12 antiplatelet agents. We examine recent evidence to guide management in 3 categories of patients with AF and CHD: patients with stable CHD, ...
Barbanti Marco M Ferrarotto Hospital, University of Catania, Catania, Italy; ETNA Foundation, Catania, Italy. Electronic address: - - 2014
The aim of this study was to assess the incidence and clinical impact of balloon post-dilation (BPD) after transcatheter aortic valve replacement (TAVR) with the CoreValve prosthesis (Medtronic Inc., Minneapolis, Minnesota). BPD is a widely adopted strategy to reduce the degree of paraprosthetic regurgitation in case of transcatheter heart valve underexpansion. However, ...
Tona F F Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padua, Italy. Electronic address: - - 2014
Coronary allograft vasculopathy (CAV) involves both epicardial vessels and coronary microcirculation. Little is known about the effect of everolimus on coronary microvasculopathy in heart transplantation (HT). The aim of our study was to assess the pathological substrate of coronary flow reserve (CFR) impairment in HT patients and the effect of ...
de Luna Antonio Bayés AB Santa Creu i Sant Pau Hospital, Cardiovascular Research Center, CSIC-ICCC, Barcelona, - - 2014
We will focus our attention in this article in the ECG changes of classical Prinzmetal angina that occur during occlusive proximal coronary spasm usually in patients with normal or noncritical coronary stenosis. The most important ECG change during a focal proximal coronary spasm is in around 50% of cases the ...
Dong Peng P Department of Cardiology, Capital Medical University, Chaoyang Hospital, Beijing 100053, China ; Department of Cardiology, Aviation General Hospital, Beijing 100012, - - 2014
In-stent thrombosis after cessation of antiplatelet medications in patients with drug-eluting stents (DES) is a significant problem in medical practice, particularly in the perioperative period. We report a case of an 87-year-old man with a medical history of hypertension, coronary artery disease and chronic atrophic gastritis. Very late thrombosis of ...
Mart Christopher Robin CR Department of Pediatrics, University of Utah School of Medicine, Provo, Utah, USA ; Primary Children's Hospital, Provo, Utah, - - 2014
With surgical palliation of hypoplastic left heart syndrome (HLHS), the tricuspid valve (TV) becomes the systemic atrioventricular valve and moderate/severe TV insufficiency (TVI), an adverse risk factor for survival to Fontan, has been reported in up to 35% of patients prior to stage I palliation. Precise echocardiographic identification of the ...
Houszka Marek - - 2014
Postmortem examination of a 43-yr-old male southern white rhinoceros (Ceratotherium simum simum) revealed gross lesions and histopathologic findings consistent with endocarditis. The animal was born in Umfolozi National Park, South Africa, and then it was moved at 2 yr of age to two successive European zoologic collections. For several weeks ...
Chau Katherine K Aortic Institute at Yale-New Haven, Yale University, School of Medicine, New Haven, - - 2014
There has been increasing evidence that ascending thoracic aortic aneurysms (TAAs) protect against atherosclerosis. However, there have been no studies examining the relationship between ascending TAAs and clinical endpoints of atherosclerosis, such as stroke or peripheral arterial disease. In this study, we aim to characterize the relationship between TAAs and ...
Chaikriangkrai Kongkiat K Department of Medicine, Houston Methodist Hospital, Houston, Texas, - - 2014
Atherosclerotic coronary artery disease (CAD) has long been shown to involve chronic low-grade subclinical inflammation. However, whether there is association between hematological indices assessed by complete blood count (CBC) and coronary atherosclerotic burden has not been well studied. Consecutive 868 patients without known CAD who presented with acute chest pain ...
Ohira Hiroshi H MFI program, National Cardiac PET Center, Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, ON, - - 2014
ABSTRACT  Cardiac PET has been evolving over the past 30 years. Today, it is accepted as a valuable imaging modality for the noninvasive assessment of coronary artery disease. PET has demonstrated superior diagnostic accuracy for the detection of coronary artery disease compared with single-photon emission computed tomography, and also has ...
Al-Shehri Abdullah M AM Department of Internal Medicine, College of Medicine, University of Dammam and King Fahd Hospital of the University, Al-Khobar, Kingdom of Saudi - - 2014
The aim of the study was to assess the prevalence and patterns of dyslipidemia in Saudi patients with angiographically documented coronary artery disease (CAD). This is a cross-sectional, hospital-based study, which was conducted on all Saudi patients who underwent coronary angiography under the author's personal care and were found to ...
Karbassi Arsha - - 2014
There have been attempts to find new approaches to the treatment of multivessel coronary artery disease without increasing adverse events. Deployment of drug-eluting stents (DES) for complex lesions and bare-metal stents (BMS) for simpler lesions, although already in wide use, has not been well supported by clinical study. A cohort ...
Sachdeva Rajesh - - 2014
The presence, severity, and extent of ischemia predict the outcome of coronary artery disease. Indeed the extent of myocardial ischemia and viability determines the value of revascularization in coronary stenosis after acute myocardial infarction. In multivessel coronary artery disease, noninvasive methods for the evaluation of ischemia are often inadequate to ...
Stidd David A DA Department of Neurosurgery, Rush University Medical Center, Chicago, IL, - - 2014
A 2-year-old boy with hypoplastic left heart syndrome that required multiple cardiovascular surgeries and a heterozygous prothrombin G20210A mutation with resulting thrombophilia maintained on warfarin presented with acute right middle cerebral artery (MCA) infarction manifesting as a left hemiplegia. An MRI revealed a complete occlusion of the right M1 segment ...
Lipinski Michael J MJ MedStar Cardiovascular Research Network, MedStar Heart Institute, Medstar Washington Hospital Center, Washington, DC, - - 2014
Given controversy over anticoagulation regimens for percutaneous coronary intervention (PCI), we performed an updated meta-analysis of randomized controlled trials (RCTs) to compare bivalirudin versus heparin. Medline/Pubmed and Cochrane CENTRAL were searched for all RCTs comparing bivalirudin with provisional glycoprotein IIb/IIIa inhibitor (GPI) use versus heparin with provisional or routine GPI ...
Pokorny Saskia S Department of Cardiovascular Surgery, Christian-Albrechts-University of Kiel, School of Medicine, Kiel, - - 2014
Aims: The evaluation of in vivo shaping of mitral valved stent prototypes using cardiac computed tomography (CT) was the focus of this study. Methods and results: Twelve pigs received a self-expanding mitral valved stent, composed of an atrial element connected to a tubular ventricular body at a modified angle (45°, ...
Retzer Elizabeth M EM Section of Cardiology, Department of Medicine, The University of Chicago, Chicago, - - 2014
Iatrogenic membranous ventricular septal defects (VSD) are rare complications of cardiothoracic surgery, most commonly seen as a complication of aortic valve replacements. An iatrogenic VSD can lead to right sided heart failure, systemic hypoxia, and arrhythmias, and closure is often necessary. Given the increased mortality associated with repeat surgical procedures, ...
Sulaiman Helmi - - 2014
This case report describes a case of presumed acute myocardial infarction in a returned traveler who was later diagnosed to have severe malaria. Emergency coronary angiography was normal and subsequent peripheral blood film was positive for Plasmodium falciparum.
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