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Steffen Robert J RJ Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, 9500 Euclid Avenue, Desk J4-1, Cleveland, OH 44195, - - 2014
Right ventricular failure is a difficult problem to manage and typically carries a dismal prognosis. In the setting of post-left ventricular assist device implantation (LVAD), right ventricular dysfunction both in the early and late stages is of particularly high incidence and concern. There are currently no agreed upon preoperative algorithms ...
Wachter Rolf R Clinic for Cardiology and Pneumology, DZHK (German Center for Cardiovascular Research), University of Göttingen, Göttingen, Germany. Electronic address: - - 2014
Heart failure with preserved ejection fraction (HFpEF) constitutes a growing health care burden worldwide. Although definitions vary somewhat among guidelines, in general the presence of typical heart failure symptoms and signs in combination with a preserved left ventricular ejection fraction (≥50%) and functional and/or structural left ventricular changes makes the ...
Vecchio Sabine S Sabine Vecchio, Elisabetta Varani, Marco Balducelli, Giuseppe Vecchi, Matteo Aquilina, Giulia Ricci Lucchi, Alessandro Dal Monte, Massimo Margheri, Division of Cardiology, Cardiac Catheterization Laboratory, Santa Maria Delle Croci Hospital, 48121 Ravenna, - - 2014
Acute ST-elevation myocardial infarction (STEMI) usually results from coronary atherosclerotic plaque disruption with superimposed thrombus formation. Detection of coronary thrombi is a poor prognostic indicator, which is mostly proportional to their size and composition. Particularly, intracoronary thrombi impair both epicardial blood flow and myocardial perfusion, by occluding major coronary arteries ...
Zhao Yuhui Y Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, - - 2014
β1-Adrenoceptor autoantibodies (β1-AAs) affect the action potential duration (APD) in cardiomyocytes and are related to ventricular arrhythmias. The delayed rectifier potassium current (I K) plays a crucial role in APD, but the effects of β1-AAs on I K have not been completely illuminated. This work aimed to observe the effects ...
Giacoppo D D Cardiology Department, Mount Sinai Hospital, New York, NY, USA - - - 2014
Dual antiplatelet therapy (DAPT) with acetylsalicylic acid and an inhibitor of the adenosine diphosphate platelet receptor P2Y12 has been shown to reduce the risk of stent thrombosis (ST), myocardial infarction and cardiac death after percutaneous coronary intervention (PCI) with bare-metal stents (BMS) and drug-eluting stents (DES). However, while there is ...
Touchan Jean J University of Florida College of Medicine, Jacksonville, Fla., - - 2014
Spontaneous subclavian artery dissection is rarely reported. We report the case of a 55-year-old female who presented as an non-ST elevation myocardial infarction (NSTEMI) and was found to have a proximal left subclavian dissection. We provide an overview of current articles addressing the clinical features and treatments of subclavian dissection. ...
Dean Boudoulas Konstantinos K Division of Cardiovascular Medicine, Department of Medicine, The Ohio State University Medical Center, Columbus, OH, USA - - 2014
Coronary artery compression during left ventricular systole is usually the result of a segment of coronary artery tunnelling within the myocardium, termed a 'myocardial bridge'. A 49-year-old man presented with acute anterior wall myocardial infarction thought to be secondary to a myocardial bridge seen during coronary arteriography; however, in the ...
Rajapreyar Indranee I 1Division of Cardiology, University of Texas, Houston, Texas 2Division of Cardiology, Centre Hospitalier Universitaire de Grenoble,France 3Department of Cardiology, Tulane University Medical School, New Orleans, - - 2014
The use of currently available positive inotropic agents is associated with an unfavorable clinical outcome. The disappointment with positive inotropic therapy is to some extent foreseeable as currently available inotropic agents may precipitate ventricular arrhythmias due to a diastolic rise in intracellular [Ca], trigger/worsen myocardial ischemia due to an increased ...
Kim Min Chul MC Department of Cardiovascular Medicine, Heart Center, Chonnam National University Hospital, Gwangju, - - 2014
Primary percutaneous coronary intervention (PCI) is a standard interventional treatment modality for ST-segment elevation myocardial infarction (STEMI). Diagnostic coronary angiogram during PCI reveals multivessel coronary artery disease in about half of patients with STEMI, and it is difficult to make decision on the extent of intervention in these patients. Although ...
Neugebauer Hermann H Department of Neurology, RKU - University and Rehabilitation Hospitals, Ulm, - - 2014
Malignant middle cerebral artery infarction is a life-threatening sub-type of ischemic stroke that may only be survived at the expense of permanent disability. Decompressive hemicraniectomy is an effective surgical therapy to reduce mortality and improve functional outcome without promoting most severe disability. Evidence derives from three European randomized controlled trials ...
Padma Subramanyam S Department of Nuclear Medicine and PET CT, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham University, Cochin, Kerala, - - 2014
Pediatric myocardial perfusion imaging (MPI) is not a routine investigation in an Indian setting due to under referrals and logistic problems. However, MPI is a frequently performed and established modality of investigation in adults for the identification of myocardial ischemia and viability. We report myocardial perfusion scintigraphy in a case ...
Elgendy Islam Y IY Department of Medicine, University of Florida College of Medicine, Gainesville, - - 2014
Revascularization of ischemia-producing coronary lesions is widely used in the management of coronary artery disease. However, some coronary lesions appear significant on the conventional angiogram when they are truly non-flow limiting. For this reason, it is becoming increasingly important to determine the coronary physiology. Fractional flow reserve (FFR) has emerged ...
Zhang Yaojun Y Thorax Center, Erasmus Medical Center, Rotterdam, 3015CE, The Netherlands; Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210006, - - 2014
To update the current status of bioresorbable scaffold, highlights the potential future prospective of innovative bioresorbable scaffold technology. Data were obtained from papers published in PubMed, presentations from the following conferences: EuroPCR, Transcatheter Cardiovascular Therapeutics, and Chinese Interventional Therapeutics. Bioresorbable scaffold has been introduced as a potential workhorse device for ...
Haq Muhammad Asrar Ul MA Muhammad Asrar ul Haq, Chiew Wong, Vivek Mutha, Nagesh Anavekar, Peter Barlis, Department of Cardiology, The Northern Hospital, Epping, VIC 3076, - - 2014
Heart failure with preserved ejection fraction (HFPEF) is common and represents a major challenge in cardiovascular medicine. Most of the current treatment of HFPEF is based on morbidity benefits and symptom reduction. Various pharmacological interventions available for heart failure with reduced ejection fraction have not been supported by clinical studies ...
Campbell Henry - - 2014
My heart bleeds for the victims of the recent flooding and the hardship and losses they are experiencing.
Sharif Dawod D Department of Cardiology, Bnai Zion Medical Center, - - 2014
The treatment of choice in acute ST-elevation myocardial infarction (STEMI) is primary percutaneous coronary intervention (PPCI). Although, thrombolysis in myocardial infarction (TIMI) and myocardial blush grade (MBG) measures provide semi-quantitative flow evaluation after PPCI, serial and quantitative volumetric flow evaluation is still lacking. Serial assessment of left anterior descending (LAD) ...
Sheng Jingwei J Research and Development Unit, National Heart Centre Singapore, - - 2014
Telocytes (TCs) with exceptionally long cellular processes of telopodes have been described in human epicardium to act as structural supporting cells in the heart. We examined myocardial chamber-specific TCs identified in atrial and ventricular fibroblast culture using immunocytochemistry and studied their electrophysiological property by whole-cell patch clamp. Atrial and ventricular ...
Giacchi G G Cardiovascular Department Ferrarotto Hospital, Catania, Italy - - - 2014
Balloon-expandable stents are currently used with satisfactory results in percutaneous coronary interventions. Unfortunately, in challenging anatomical patterns such as high thrombotic burden lesions, outcomes are often impaired. The STENTYS® stent (STENTYS, Paris, France), with its self-expandable capacity and peculiar Z-shape design, has been recently introduced in the clinical arena as ...
Klyachkin Yuri M YM Gill Heart Institute and Division of Cardiovascular Medicine, University of Kentucky and Lexington VA Medical Center, Lexington, KY 40536-020, - - 2014
Despite significant advances in medical therapy and interventional strategies, the prognosis of millions of patients with acute myocardial infarction (AMI) and ischemic heart disease (IHD) remains poor. Currently, short of heart transplantation with all of its inherit limitations, there are no available treatment strategies that replace the infarcted myocardium. It ...
Honda Tsuyoshi - - 2013
Acute myocardial infarction (AMI) is prevalent and has serious consequences including re-infarction and death. Cigarette smoking is a coronary risk factor for AMI, although a "smoker's paradox" for AMI has been reported in Western countries. On the other hand, some researchers have reported that smoking is associated with subacute stent ...
Prazeres Carlos Eduardo Elias Dos - - 2013
The coronary computed tomography angiography has recently emerged as an accurate diagnostic tool in the evaluation of coronary artery disease, providing diagnostic and prognostic data that correlate directly with the data provided by invasive coronary angiography. The association of recent technological developments has allowed improved temporal resolution and better spatial ...
Givertz Michael M - - 2013
Although the long term prognosis of patients with dilated cardiomyopathy (DCM) remains poor, approximately 25 % of DCM patients with recent onset of heart failure (< 6 months) have a relatively benign clinical course with a spontaneously improvement in symptoms and partial, or in some cases complete, recovery of left ventricular (LV) ...
Al-Zaiti Salah S - - 2013
Current guidelines recommend early reperfusion therapy for ST-elevation myocardial infarction (STEMI) within 90min of first medical encounter. Telecardiology entails the use of advanced communication technologies to transmit the prehospital 12-lead electrocardiogram (ECG) to offsite cardiologists for early triage to the cath lab; which has been shown to dramatically reduce door-to-balloon ...
Trippel Tobias D - - 2013
The detrimental pathophysiology of heart failure (HF) leaves room for physiologic and metabolomic concepts that include supplementation of micronutrients and macronutrients in these patients. Hence myocardial energetics and nutrient metabolism may represent relevant treatment targets in HF. This review focuses on the role of nutritive compounds such as lipids, amino ...
Rossignol Patrick - - 2013
Introduction: Despite widespread use of loop diuretics in congestive heart failure (HF) to achieve decongestion and relief of symptoms, as recommended by the current guidelines, there is uncertainty as to their long-term therapeutic efficacy and safety. Their efficacy and safety compared to venous ultrafiltration are currently under investigation in acute ...
Seiler Christian - - 2013
Coronary collaterals are an alternative source of blood supply to myocardium jeopardized by ischaemia. In comparison with other species, the human coronary collateral circulation is very well developed. Among individuals without coronary artery disease (CAD), there are preformed collateral arteries preventing myocardial ischaemia during a brief vascular occlusion in 20-25%. ...
Zimarino Marco - - 2013
In patients with multi-vessel coronary artery disease (MVCAD) myocardial revascularization may be accomplished either on all diseased lesions - complete myocardial revascularization - or on selectively targeted coronary segments by percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG). Complete revascularization has a potential long-term prognostic benefit, but is ...
van Empel Vanessa P M - - 2013
Approximately half of all patients with heart failure (HF) have a preserved left ventricular ejection fraction (HFPEF) and the prevalence of this form of HF is increasing. Although dyspnoea on exertion and diminished functional capacity is the key symptom of patients with HFPEF, current diagnostic criteria focus on resting indices ...
Cilingiroglu Mehmet - - 2013
Congestive heart failure (CHF) secondary to ischemic cardiomyopathy is associated with significant morbidity and mortality despite currently available medical therapy. The Parachute(TM) device is a novel left ventricular partitioning device that is delivered percutaneously in the left ventricle (LV) in patients with anteroapical regional wall motion abnormalities, dilated LV and ...
Yu Yang - - 2013
We report a case of a 62-year-old Chinese man with typical triple-vessel lesions and apical left ventricular aneurysm accompanied with ventricular tachycardia. Off-pump coronary artery bypass (OPCAB) grafting was performed in combination with epicardial unipolar radiofrequency ablation and linear closure of left ventricular aneurysm. The patient recovered well without postoperative ...
Huang Xin-sheng - - 2013
In patients with coronary disease and aneurysm, ventricular reconstruction with revascularization is a surgical option. Details of patient selection and optimal surgical technique are still debated. We report our results with off-pump aneurysm plication after ventricular aneurysm with relative wall thinning. We retrospectively reviewed the records of 248 patients who ...
Madonna Rosalinda - - 2013
The concept of electrical protection of the ischemic myocardium is in constant evolution and has recently been supported by experimental and clinical studies. Historically, antiplatelet agents, angiotensin-converting enzyme inhibitors, β-blockers, and statins have been all proposed as drugs conferring anti-ischemic cardioprotection. This was supported by the evidence consistently indicating that ...
Maier Lars S - - 2013
In this article we review the late Na current which functionally can be measured using patch-clamp electrophysiology (INa,late). This current is largely enhanced under pathological myocardial conditions such as ischemia and heart failure. In addition, INa,late can cause systolic and diastolic contractile dysfunction via a Na-dependent Ca-overload of the myocyte. ...
Lan Yun-Feng - - 2013
To investigate the effect of nerve growth factor (NGF) on the action potential and potassium currents of non-infarcted myocardium in the myocardial infarcted rabbit model. Rabbits with occlusion of the left anterior descending coronary artery were prepared and allowed to recover for eight weeks (healed myocardial infarction, HMI). During ligation ...
Klug Gert - - 2013
Myocardial recovery after revascularization for ST-segment elevation myocardial infarction (STEMI) remains a significant diagnostic and, despite novel treatment strategies, a therapeutic challenge. Cardiovascular magnetic resonance (CMR) has emerged as a valuable clinical and research tool after acute STEMI. It represents the gold standard for functional and morphological evaluation of the ...
Ali Fahad - - 2013
Coronary artery disease (CAD) remains the major cause of mortality and morbidity in the United States despite significant advances for the prevention and treatment of CAD. Coronary artery spasm causing demand-supply mismatch with coronary ischemia can mimic CAD, resulting in unnecessary interventions. Left main coronary artery spasm, in particular, is ...
Stiermaier T - - 2013
Recent advances in percutaneous coronary intervention (PCI) have rekindled interest in this treatment modality also in the setting of unprotected left main stenosis. Randomized trials reported a similar risk of death or myocardial infarction between PCI and coronary artery bypass grafting (CABG). However, rates of stroke were higher after CABG, ...
Remme Carol Ann - - 2013
The late sodium current has been increasingly recognized for its mechanistic role in various cardiovascular pathologies, including angina pectoris, myocardial ischemia, atrial fibrillation, heart failure and congenital long QT syndrome. Although relatively small in magnitude, the late sodium current (I(NaL)) represents a functionally relevant contributor to cardiomyocyte (electro)physiology. Many aspects ...
Overman David M - - 2013
Unbalanced atrioventricular septal defect (uAVSD) is a challenging lesion with suboptimal outcomes in the current era. Severe forms of uAVSD mandate univentricular repair with well-documented outcomes. Determining the feasibility of biventricular repair (BVR) in patients with moderate forms of uAVSD is difficult. Ventricular hypoplasia has traditionally formed the cornerstone of ...
Kim Young-Hak - - 2013
Current evidence and guidelines support the strategy of ischemia-guided revascularization for treatment of patients with stable coronary symptoms. However, anatomical stenosis is often targeted in revascularization treatment using percutaneous coronary intervention or coronary artery bypass surgery without seriously considering objective evidence of myocardial ischemia. Particularly, for patients with multivessel disease, ...
Jaguszewski Milosz - - 2013
Acute coronary syndromes are frequently caused by "vulnerable" coronary plaques with a lipid-rich core. In 1993 near-infrared spectroscopy (NIRS) was first used to detect the lipid (cholesterol) content of atherosclerotic plaques in an experimental animal study. NIRS was then carefully validated using human atherosclerotic plaques (ex vivo), and has subsequently ...
Lunkenheimer Paul P - - 2012
The architectural arrangement of cardiomyocytes aggregated together within the ventricular walls remains controversial. Two models currently attract clinical attention, with neither model standing rigorous anatomical scrutiny. The first is based on the notion that ventricular mass can be unraveled consistently to produce a unique myocardial band. The second model was ...
Liu Yingwei - - 2012
PURPOSE OF REVIEW: Heart failure is a major health problem with significant morbidity and mortality. Although impressive advances in treatment and reduction in mortality have marked heart failure with reduced ejection fraction (HFrEF), the mortality in patients with heart failure with preserved ejection fraction (HFpEF), which accounts for nearly half ...
Prasad Vinay - - 2012
Current clinical practice for patients presenting to the emergency department with a resolved episode of chest pain and no electrographic or biomarker abnormalities is to conduct routine noninvasive testing, in accordance with American College of Cardiology and American Heart Association guidelines. The rationale is to further reduce the risk of ...
Loh Joshua P - - 2012
The paclitaxel drug-coated balloon (DCB) is an emerging device in percutaneous coronary intervention, which has shown promising results by means of a high-concentration, rapid local release of an antirestenotic drug without the use of a durable polymer or metal scaffold. DCB have already proven effective in clinical trials for the ...
Teirstein Paul S - - 2012
The introduction of drug-eluting stents and advances in catheter techniques have led to increasing acceptance of percutaneous coronary intervention (PCI) as a viable alternative to coronary artery bypass graft (CABG) for unprotected left main disease. Current guidelines state that it is reasonable to consider unprotected left main PCI in patients ...
Rognoni Andrea - - 2012
In a variant proportion of patients presenting with chest pain and electrocardiographic changes charactheristic for ST - elevation myocardial infarction, percutaneous coronary intervention achieve epicardial coronary artery reperfusion but not myocardial reperfusion (ranging from 5% to 50%); furthermore, prolonged myocardial ischemia often breaks down the coronary microvasculature and the flow ...
Tota-Maharaj Rajesh - - 2012
Although coronary artery calcium (CAC) scoring has an established role in risk-stratifying asymptomatic patients at intermediate risk of coronary heart disease (CHD), its utility in the evaluation of patients with chest pain is uncertain. We conducted a literature review of articles investigating the utility of: (1) CAC scoring in elective ...
Marshall Andrew - - 2012
To assess the prognostic value of cardiac iodine-123 metaiodobenzylguanidine ((123)I-MIBG) scintigraphy to predict ventricular arrhythmias in patients with heart failure (HF) listed for implantable cardioverter-defibrillator (ICD) devices as primary prevention. A prospective cohort study in 27 patients with HF referred for ICD implantation (alone or in combination with cardiac resynchronisation ...
Groner Abraham - - 2012
Introduction The prevalence of right ventricular dysfunction in idiopathic dilated cardiomyopathy is incompletely studied in children. Furthermore, right ventricular function may signal worse outcomes. We evaluated recently published right ventricular function echocardiographic indices in identifying dysfunction in children with idiopathic dilated cardiomyopathy and the impact of right ventricular dysfunction on ...
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