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Rider Oliver J OJ Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK. - - 2012
Obesity is characterized by impaired cardiac energetics, which may play a role in the development of diastolic dysfunction and inappropriate shortness of breath. We assessed whether, in obesity, derangement of energetics and diastolic function is further altered during acute cardiac stress. Normal-weight (body mass index, 22±2 kg/m(2); n=9-17) and obese ...
Zarifeh Julie A - - 2012
Aims:  To compare psychological factors in patients presenting to hospital with earthquake induced stress cardiomyopathy, myocardial infarction and non-cardiac chest pain. We hypothesised that patients with stress cardiomyopathy and non-cardiac chest pain would be more psychologically vulnerable than those with myocardial infarction. Methods:  Cardiology admitting staff in the week following ...
Panduranga Prashanth - - 2012
A 60-year-old male hypertensive was suspected to have post myocardial infarction left ventricular aneurysm. His transthoracic echocardiogram performed elsewhere reported an inferior wall left ventricular aneurysm. He was referred for coronary angiography. His coronary angiogram and repeat transthoracic echocardiogram demonstrated an accessory chamber arising from mid-inferior wall synchronously contracting with ...
Providência Rui - - 2012
BACKGROUND: Evidence of a link between small rises in cardiac troponin I (cTnI) and an increased risk of thromboembolic events (TE) in atrial fibrillation (AF) is currently scarce. OBJECTIVES: We aimed to assess the relation between cTnI and findings of an increased thromboembolic risk in patients with non-valvular AF using ...
Baker Nevin C - - 2012
Enlarged cardiac silhouette on chest x-ray (CXR) in the absence of cardiopulmonary disease is often dismissed as "pseudocardiomegaly." We aimed to assess the impact of epicardial adipose tissue (EAT) on radiographic heart size and to determine the clinical significance of cardiomegaly caused by EAT. In total 112 patients (52 ± ...
Jou Yu-Lan - - 2012
Objectives: We aimed to assess the prognostic values of the EuroSCORE, SYNTAX score, and the novel Clinical SYNTAX score (CSS) for 30-day and 1-year outcomes in patients undergoing left main (LM) percutaneous coronary intervention (PCI). Background: PCI has become an alternative treatment for LM coronary artery disease, and risk scoring ...
Movva Rajesh R Albert Einstein Medical Center, Philadelphia, PA 19141, United - - 2013
Alcohol has been consumed by most societies over the last 7000 years. Abraham Lincoln said "It has long been recognized that the problems with alcohol relate not to the use of a bad thing, but to the abuse of a good thing." Light to moderate alcohol consumption reduces the incidence ...
Welles Christine C CC Department of Medicine, University of California, San Francisco, California; Veterans Affairs Medical Center, San Francisco, California, - - 2012
This study sought to determine whether left atrial (LA) dysfunction predicts heart failure (HF) hospitalization in subjects with preserved baseline ejection fraction (EF). Among patients with preserved EF, factors leading to HF are not fully understood. Cross-sectional studies have demonstrated LA dysfunction at the time of HF, but longitudinal data ...
Valocik Gabriel - - 2012
The aim of our study was to assess the diagnostic accuracy of a global longitudinal strain and strain rate (GLS, GLSR) and mean radial strain and strain rate (MRS, MRSR) of the left ventricle to predict multivessel disease. In 113 patients, who underwent coronary angiography, left ventricular deformation was analysed ...
Capodanno Davide - - 2012
The Synergy Between Percutaneous Coronary Intervention With TAXUS and Cardiac Surgery (SYNTAX) score is a useful tool to guide decision-making in patients undergoing three-vessel disease and left main percutaneous coronary intervention. However, someone perceives the SYNTAX score as a labor-intensive surrogate with no added utility over clinical judgment and technical ...
Segers Vincent F M - - 2012
PURPOSE OF REVIEW: Pulmonary hypertension and right heart failure are common findings in patients suffering from heart failure with preserved ejection fraction (HFpEF). In this review, we summarize our current understanding of the pathophysiology of pulmonary hypertension related to heart failure. RECENT FINDINGS: HFpEF is a clinical syndrome with increasing ...
Aksakal Enbiya - - 2012
BACKGROUND: Relation of serum gamma-glutamyl transferase (GGT) levels with extent, severity, and complexity of coronary artery disease has not been adequately studied. Therefore, we evaluated the relationship between GGT levels and coronary complexity, severity and extent assessed by SYNTAX score and long-term adverse events. METHODS: We enrolled 442 consecutive patients ...
Ishikawa Kiyotake - - 2012
Among the various cardiac contractility parameters, left ventricular (LV) ejection fraction (EF) and maximum dP/dt (dP/dt(max)) are the simplest and most used. However, these parameters are often reported together, and it is not clear if they are complementary or redundant. We sought to compare the discriminative value of EF and ...
Algahim Mohamed F - - 2012
Obesity is an independent risk factor for cardiovascular disease. Data from the Framingham Study have reported a higher incidence of heart failure in obese individuals compared with a normal cohort. The body initially copes with the abundance of fuel present in an obese milieu by storing it in adipose tissue. ...
Kucukler Nagehan - - 2012
BACKGROUND: It has been shown by various diagnostic methodologies that angiotensin receptor blockage reduces left ventricular mass, improves diastolic function and increases contractility in hypertensive left ventricular hypertrophy (LVH). We planned to detect the effect of angiotensin receptor blockage on midwall mechanics and myocardial dynamics in hypertensive patients with LVH. ...
Gillis David B - - 2012
We estimate likelihood of presenting rhythms and survival to hospital discharge outcome after acute cardiac ischemia with arrhythmia and/or myocardial infarction (AMI) during long-duration space missions (LDSM) using selected terrestrial cohorts in medical literature. Medical scenarios were risk-stratified by coronary artery calcium score (CAC) and Framingham risk factors (FRF). AMI ...
Hawkins Beau M - - 2012
Background: Coronary slow flow phenomenon (CSFP) is defined as delayed coronary opacification in the absence of obstructive coronary artery disease. In the present study, we sought to define its prevalence and clinical features. Methods and Results: The 1,741 consecutive patients who underwent coronary angiography (CAG) were identified. Those with normal ...
Correale Michele - - 2012
Recent studies have explored the prognostic role of TDI-derived parameters in major cardiac diseases, such as coronary artery disease (CAD) and heart failure (HF). In these conditions, myocardial mitral annular systolic (S') and early diastolic (E') velocities have been shown to predict mortality or cardiovascular events. In heart failure non ...
Yacoub Sophie S Department of Infection and Immunity, Imperial College, London, UK. - - 2012
Dengue continues to cause significant global morbidity and mortality. Severe disease is characterized by cardiovascular compromise from capillary leakage. Cardiac involvement in dengue has also been reported but has not been adequately studied. Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam. Seventy-nine patients aged 8-6 yrs with different dengue ...
Kershaw O - - 2012
Hypertrophic cardiomyopathy (HCM) is the most common form of feline heart disease. To date, reliable morphometric reference data for anatomical or histological changes are unavailable. The aim of this study was to identify diagnostically relevant morphometric criteria that clearly distinguish feline HCM from normal hearts. Hearts from 15 cats with ...
Patel Yogesh - - 2012
Percutaneous coronary intervention (PCI) of bifurcation lesions remains challenging with a higher risk of adverse outcomes. Whether adjunctive intravascular ultrasound (IVUS) imaging improves outcomes of PCI of bifurcation lesions remains unclear. This study sought to determine the long-term clinical outcomes associated with using IVUS for percutaneous treatment of coronary bifurcation ...
Sinning Jan-Malte - - 2012
BACKGROUND: Risk stratification is essential for the clinical decision-making process in patients undergoing revascularization of the unprotected left main coronary artery (ULMCA), since the optimal revascularization strategy still remains subject of ongoing debate. OBJECTIVES: To assess the prognostic value of angiographic versus clinical characteristics for the prediction of major adverse ...
Méndez-Eirín Elizabet - - 2012
We sought to compare the predictive value of the Thrombolysis In Myocardial Infarction (TIMI), Controlled Abciximab and Device Investigation to Lower Late Angioplasty Complications (CADILLAC), Primary Angioplasty in Myocardial Infarction (PAMI), and Global Registry for Acute Coronary Events (GRACE) scores for the outcome of ST-segment elevation acute coronary syndrome undergoing ...
Wang Yves T YT Department of Molecular Cardiology, Cleveland Clinic, Cleveland, Ohio 44195, - - 2012
Cardiac remodelling following myocardial infarction (MI) is a complex, dynamic process. There have been few longitudinal studies of these changes. A 2-dimensional transthoracic echocardiography was performed on 20 rabbits, before and 1, 2, 4, 8, and 12 weeks after MI (n = 14) and twice for controls (n = 6). ...
Park H E - - 2012
The relation between left ventricular (LV) hypertrophy and LV function is well known. However, less is known about the vascular changes influenced by LV geometry. We sought to investigate the relationship of LV geometry to carotid arterial and LV function. A total of 476 hypertensive patients were prospectively recruited. All ...
Lee Seung-Whan - - 2012
Background: To date, drug-eluting stent (DES) implantation has not been compared with coronary artery bypass grafting (CABG) for ostial left main coronary artery (LMCA) lesions. Methods: Of the 263 patients in the MAIN-COMPARE registry with ostial LMCA stenosis, 123 were treated with percutaneous coronary intervention (PCI) with DES and 140 ...
Nakazato Ryo - - 2012
OBJECTIVE: Epicardial fat volume (EFV) is linked to cardiovascular event risk. The aim of this study was to evaluate whether EFV is independently related to concurrent presence of both myocardial ischemia and obstructive coronary stenosis. METHODS: We studied 92 consecutive patients without known coronary artery disease (CAD) who underwent Rb-82 ...
González-Pacheco Héctor - - 2012
Introduction: Patients with ST elevation acute myocardial infarction (STEMI) comprise a heterogeneous population with respect to the risk for adverse events. Primary percutaneous coronary intervention (PCI) has shown to be better, mainly in high-risk patients. Objective: The purpose of this study was to determine if the Thrombolysis in Myocardial Infarction ...
Simula Sakari - - 2012
Background: Myocardial (123) I-metaiodobenzylguanidine (MIBG) kinetics reflect the integrity and function of cardiac presynaptic sympathetic nerve terminals. Heart rate variability (HRV) is an indicator of cardiac sympatho-vagal balance. However, the function of cardiac sympathetic nerve terminals as a modulator of HRV in asymptomatic subjects has remained elusive. In addition, the ...
Karbowska Joanna - - 2012
 Obesity is now recognised as one of the most important risk factors for heart disease. Obese individuals have high circulating levels of leptin, a hormone secreted by adipose tissue and in-volved in energy homeostasis. Growing evidence suggests that leptin may contribute to the development of cardiac dysfunction. In a large ...
Evola Salvatore - - 2012
Objective In hypertensive patients with typical chest pain but absence of coronary stenosis the coronary microcirculation may be impaired, thus, our study aimed to appraise, in these subjects, the role of the coronary microcirculation, assessed by Myocardial Blush Grade (MBG) and Thrombolysis in Myocardial Infarction (TIMI) Frame Count (TFC). Methods ...
Poyraz Fatih - - 2012
Purpose: The purpose of this study was to evaluate whether a association exits among overweight and obesity and left ventricular systolic and diastolic functions in patients admitted with first ST-elevation myocardial infarction (STEMI). Methods: The present study was performed on 451 consecutive patients diagnosed with first STEMI (376 men, 75 ...
Rajiah Prabhakar - - 2012
Recent advances in scanner technology have enabled computed tomography (CT) scan to evolve into a valuable tool in the noninvasive evaluation of coronary artery disease. Due to its high negative predictive value, CT can act as a gatekeeper, determining which patients require cardiac catheterization. Although mainly used for the evaluation ...
Charumathi Dasarathan - - 2012
Post-infarction ventricular aneurysm is a complication of myocardial infarction. While the involvement of the anterior wall is quite common, posterobasal left ventricular aneurysm is a rare clinical complication in this setting. In this case report, we report a post-infarction posterobasal left ventricular aneurysm combined with ischemic mitral regurgitation due to ...
Galderisi Maurizio - - 2012
Age may affect coronary flow reserve (CFR) especially in subjects with atherosclerotic risk factors (ARFs). The aim of this prospective, multicenter, observational study was to determine the effects of aging on CFR in patients with normal epicardial coronary arteries and ARFs. Three-hundred-thirty-five subjects (mean age = 61 years) with at least one ARF ...
Bonomini Maria P - - 2012
An allometric relationship between different electrocardiogram (ECG) parameters and infarcted ventricular mass was assessed in a myocardial infarction (MI) model in New Zealand rabbits. A total of fifteen animals were used, out of which ten underwent left anterior descending coronary artery ligation to induce infarction (7-35% area). Myocardial infarction (MI) ...
Koelsch Stefan - - 2012
There are well-established relations between personality and the heart, as evidenced by associations between negative emotions on the one hand, and coronary heart disease or chronic heart failure on the other. However, there are substantial gaps in our knowledge about relations between the heart and personality in healthy individuals. Here, ...
Sonne Carolin - - 2012
Post-implantation therapies to optimize cardiac resynchronization therapy (CRT) focus on adjustments of the atrio-ventricular (AV) delay and ventricular-to-ventricular (VV) interval. However, there is little consensus on how to achieve best resynchronization with these parameters. The aim of this study was to examine a novel combination of doppler echocardiography (DE) and ...
Mingels Alma M - - 2012
Recent studies have demonstrated the association between increased concentrations of high-sensitivity cardiac troponin T (hs-cTnT) and the incidence of myocardial infarction, heart failure, and mortality. However, most prognostic studies to date focus on the value of hs-cTnT in the elderly or general population. The value of hs-cTnT in symptomatic patients ...
Narasimhan Seshasayee - - 2012
We report 2 noteworthy cases of very late stent thrombosis presenting as ST-segment-elevation myocardial infarction, with vastly different manifestations. Both patients were women who had histories of multivessel percutaneous coronary intervention with first-generation sirolimus-eluting stents, in 2005 and 2006. On the more recent occasions reported here, one underwent successful multivessel ...
Shah Nishant R - - 2012
As public awareness and clinical use of CAC screening increases, physicians should, at a minimum, know the following information: 1) The presence of CAC indicates underlying CHD but does not predict luminal obstruction. 2) Non-contrast, prospectively ECG-gated cardiac EBCT and MDCT are sensitive, reproducible, rapid, and essentially equivalent imaging techniques ...
Akintunde A A - - 2012
Various conventional methods are used for functional evaluation and risk stratification in heart failure. A combined index of global myocardial performance called the Tei index has been described. The aim of this study was to evaluate the correlation of the Tei index with other conventional indices of systolic and diastolic ...
Chue Colin D CD School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United - - 2012
Vascular calcification and reduced bone density are prevalent in chronic kidney disease and linked to increased cardiovascular risk. The mechanism is unknown. We assessed the relationship between vascular calcification, femoral bone density and left ventricular mass in patients with stage 3 non-diabetic chronic kidney disease in a cross-sectional observational study. ...
Bandosz Piotr P Department of Hypertension and Diabetology, Medical University in Gdansk, - - 2012
To examine how much of the observed rapid decrease in mortality from coronary heart disease in Poland after the political, social, and economic transformation in the early 1990s could be explained by the use of medical and surgical treatments and how much by changes in cardiovascular risk factors. A modelling ...
Biswas Shankar K SK Department of Radiology, Fujita Health University Hospital, Dengakugakubo, Kutsukake, Toyoake, Aichi, Japan. - - 2012
Following acute myocardial infarction (AMI) the area of myocardial perfusion and metabolism mismatch is designated as dysfunctional viable myocardium. (123)I-beta-methyl iodophenyl pentadecanoic acid (BMIPP) is clinically very useful for evaluating myocardial fatty acid metabolism, and (99)mTc-Tetrofosmin (TF) is a widely used tracer for myocardial perfusion. This study was designed to ...
Huang Shao-Sung - - 2011
BACKGROUND: Thrombolysis in Myocardial Infarction (TIMI) score and Global Registry of Acute Coronary Events (GRACE) score have been validated as predictors of death in patients with acute myocardial infarction (AMI). This study was undertaken to determine whether the Sequential Organ Failure Assessment (SOFA) score had good accuracy for predicting mortality ...
Badran Hala Mahfouz - - 2011
AIMS: Hypertrophic cardiomyopathy (HCM) is usually associated with electrocardiographic (ECG) abnormalities. QT interval and its dispersion can be clinical markers of electrophysiological instability and ventricular arrhythmias. We aimed to clarify the relation of QT variables to mechanical dyssynchrony and myocardial function in HCM. METHODS AND RESULTS: The study population comprised ...
Carlsson M - - 2012
We aimed to quantify kinetic energy (KE) during the entire cardiac cycle of the left ventricle (LV) and right ventricle (RV) using four-dimensional phase-contrast magnetic resonance imaging (MRI). KE was quantified in healthy volunteers (n = 9) using an in-house developed software. Mean KE through the cardiac cycle of the ...
Das Sandeep R - - 2011
The aim of this study was to assess the impact of extreme (class III) obesity (body mass index [BMI] ≥40 kg/m(2)) on care and outcomes in patients with ST-segment elevation myocardial infarction (STEMI). Although its prevalence is increasing rapidly, little is known about the impact of extreme obesity on STEMI ...
Wei Gao - - 2011
Objectives:  To evaluate the association between N-terminal pro-B-type natriuretic peptide (NT-proBNP) values and the severity of coronary lesions at angiography in unstable angina patients with preserved left ventricular function. Methods:  A total of 133 patients with primary diagnosis of unstable angina were enrolled into this study. NT-proBNP level was determined ...
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