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Aus dem Siepen Fabian F Department of Cardiology, Angiology and Pneumology, University Hospital Heidelberg, Im Neuenheimer Feld 410, Heidelberg 69120, - - 2014
The aim of this study was to determine the value of extracellular volume fraction (ECV) for the non-invasive assessment of diffuse myocardial fibrosis (MF) in different stages of systolic left ventricular (LV) dysfunction in dilated cardiomyopathy (DCM) in comparison with endomyocardial biopsy. Non-invasive ECV assessment using cardiovascular magnetic resonance (CMR) ...
Gupta A A Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, - - 2014
We have previously shown rapid reversal of left ventricular hypertrophy (LVH) with 6 months of spironolactone therapy in patients with resistant hypertension (HTN), preserved left ventricular ejection fraction and no history of heart failure. In this substudy, we investigated the effect of mineralocorticoid receptor blockade with spironolactone on pre-clinical diastolic ...
Wang Chih-Hsien CH Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan Department of Surgery, National Taiwan University Hospital, Hsin-Chu Branch, Hsin-Chu, - - 2014
Our team demonstrated in the past that pyridoxamine attenuated arterial stiffening by targeting the pathogenic formation of glycated collagen cross-links in aged rats. Herein, we examined whether pyridoxamine therapy can protect against mechanical defects in myocardial relaxation by improving arterial wave properties and cardiac contractile performance in senescence animals. Fifteen-month-old ...
Sun Lili L Department of Emergency Medicine, Beijing Jishuitan Hospital, Beijing 100035, - - 2014
The study was designed to explore the role of hydrogen sulfide (H2S) in the regulation of myocardial collagen remodeling in spontaneously hypertensive rats (SHRs) and its possible mechanisms. We treated nine-week-old male SHRs and age- and sex-matched Wistar-Kyoto rats (WKYs) with NaHS (90 μmol·kg(-1)·day(-1)) for 9 weeks. At 18 weeks, ...
Abdullah Osama M OM Department of Bioengineering, University of Utah, Salt Lake City, UT, - - 2014
Non-invasive imaging techniques are highly desirable as an alternative to conventional biopsy for the characterization of the remodeling of tissues associated with disease progression, including end-stage heart failure. Cardiac diffusion tensor imaging (DTI) has become an established method for the characterization of myocardial microstructure. However, the relationships between diffuse myocardial ...
Engebretsen Kristin V KV Department of Cardiothoracic Surgery, Oslo University Hospital Ullevål, Oslo, Norway; Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway; KG Jebsen Cardiac Research Center and Center for Heart Failure Research, Oslo, - - 2014
Pressure overload-induced TGF-β signaling activates cardiac fibroblasts (CFB) and leads to increased extracellular matrix (ECM) protein synthesis including fibrosis. Excessive ECM accumulation may in turn affect cardiac function contributing to development of heart failure. The aim of this study was to examine the effects of SM16, an orally active small ...
Liu Chang C Division of Cardiac Surgery, Department of Surgery, The First Affiliate Hospital of Harbin Medical University, Harbin, - - 2014
Cardiac repair and remodeling occur following myocardial infarction (MI). Our previous study demonstrated that platelet-derived growth factor (PDGF)-A/-D and PDGF receptors (PDGFR) are increased in the infarcted heart, with cells expressing PDGFR primarily endothelial and fibroblast-like cells. In the present study, we tested the hypothesis that PDGF contributes to cardiac angiogenesis ...
Yin Yi-Gang YG Cardiovascular Institute, People's Hospital of Taizhou, Taizhou 235000, - - 2014
To study the effects of phentolamine on myocardial extracellular matrix of cardiac remodeling induced by norepinephrine in rats. 24 SD rats were divided into 3 groups randomly: control groups, norepinephrine groups (model groups), norepinephrine +phentolamine groups (treatment groups). Echocardiography was used to detect changes in cardiac structure and function, the ...
Huemer Martin M Department of Cardiology, Charité - University Medicine Berlin, Campus Virchow-Klinikum, Berlin, - - 2014
Catheter ablation of atrial fibrillation has been associated with left-sided phrenic nerve palsy. Knowledge of the individual left phrenic nerve course therefore is essential to prevent nerve injury. The aim of this study was to test the feasibility of an intraprocedural pace mapping and reconstruction of the left phrenic nerve ...
Lee Seung-Jae SJ Department of Neurology, Sejong General Hospital, Bucheon, South - - 2014
Cerebral infarct related to varicella-zoster virus (VZV) has been reported in the literature. In addition, lateral medullary infarct (LMI) can be manifested rarely as isolated gait ataxia without other characteristic symptoms. A 70-year-old female was admitted to our hospital because of herpes zoster on the right trigeminal nerve distribution. On ...
Saburkina Inga I Institute of Anatomy, Faculty of Medicine, Lithuanian University of Health Sciences, Kaunas, - - 2014
Although the rabbit is routinely used as the animal model of choice to investigate cardiac electrophysiology, the neuroanatomy of the rabbit heart is not well documented. The aim of this study was to examine the topography of the intrinsic nerve plexus located on the rabbit heart surface and interatrial septum ...
Guo Zheng Z Department of Anesthesiology, Shanxi Medical University and Second Hospital of Shanxi Medical University, 56 Xinjian Nan Road, Taiyuan 030001, Shanxi, China; Key Laboratory of Cellular Physiology (Shanxi Medical University), National Education Commission. Electronic address: - - 2014
Nerve growth factor (NGF) plays important roles in transmission of nociception, neural innervation and survival in sympathetic and sensory neurons. Evidence indicates that NGF may sensitize the sensory and sympathetic reaction upon noxious stimulation. Understanding of the alterations of NGF in the sensory neurons during acute myocardial infarction and the ...
Li Xiaodi X Department of Neurology, Guangdong 999 Brain Hospital, Shatai Road, 578, Guangzhou, 510510, - - 2014
Here, we present a rare case of a lateral medullary infarction with ipsilateral hemiparesis, lemniscal sensation loss and hypoglossal nerve palsy. In this case, we proved Opalski's hypothesis by diffusion tensor tractography that ipsilateral hemiparesis in a medullary infarction is due to the involvement of the decussated corticospinal tract. We ...
Nicholson Luke L Department of Ophthalmology, Singleton Hospital, Swansea, Wales, - - 2014
We present a rare case of unilateral lateral rectus palsy following an elective coronary angiography and percutaneous coronary intervention in a 78-year-oldwoman. Ophthalmoplegia following coronary angiography is extremely rare and this is the first case of a unilateral lateral rectus palsy following the procedure.
Chowdhury Tumul T 0000-0002-8946-4148 Department of Anesthesia and Perioperative Medicine, Health Sciences Center, University of Manitoba, 671 William Avenue, Winnipeg, Canada R3E - - 2014
Background. Coronary artery spasm (CAS) is a rarely reported complication in neurosurgical patients and its main causative mechanism was attributed to vagal mediated responses. However, these may be the unusual manifestations of trigeminal cardiac reflex (TCR) which is a well established brain stem reflex observed in various neurosurgical patients. Methods ...
Zhou Hao H Department of Cardiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China. - - 2014
Scutellarin (SCU) is the major active component of breviscapine and has been reported to be capable of decreasing myocardial fibrosis. The aim of the present study is to investigate whether SCU treatment attenuates isoprenaline-induced myocardial fibrosis and the mechanisms of its action. Rats were injected subcutaneously with isoprenaline (Iso) to ...
Jia Yin-Yu YY Department of Cardiology, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, - - 2013
Aliskiren is an oral renin inhibitor, which inhibits the first rate limiting step in the renin angiotensin aldosterone system. In this study, sympathetic nerve sprouting and the inducibility of ventricular fibrillation after aliskiren treatment in myocardial infarction were investigated. Male Sprague Dawley rats after coronary artery ligation were randomly allocated ...
Dehlin Heather M - - 2013
The tachykinin, substance P, is found primarily in sensory nerves. In the heart, substance P-containing nerve fibers are often found surrounding coronary vessels, making them ideally situated to sense changes in the myocardial environment. Recent studies in rodents have identified substance P as having dual roles in the heart, depending ...
Piccirillo Gianfranco - - 2013
Evidence from a canine experimental acute myocardial infarction (MI) model shows that until the seventh week after MI the relationship between stellate ganglionic nerve and vagal nerve activities (SGNA/VNA) progressively increases. We evaluated how autonomic nervous system activity influences temporal myocardial repolarization dispersion at this period. We analyzed autonomic nerve ...
Zhang Fengxiang - - 2013
Neural remodeling after myocardial infarction (MI) may cause malignant ventricular arrhythmia, which is the main cause of sudden cardiac death following MI. Herein, we aimed to examine whether iPSc transplantation can ameliorate neural remodeling and reduce ventricular arrhythmias (VA) in a post-infarcted swine model. Left anterior descending coronary arteries were ...
Ng G Andre - - 2013
Sudden cardiac death remains a significant unresolved clinical problem with many of the deaths due to malignant ventricular arrhythmias. Markers of abnormal autonomic function have been shown to be strong prognostic predictors highlighting the important relationship between reduced vagal tone and malignant ventricular arrhythmias such as ventricular fibrillation in cardiac ...
Kawasaki Akiko - - 2013
Clinicoradiological correlations observed in patients with small cortical infarctions have supported somatotopic representation of different parts of body areas in primary motor cortex. However, isolated shoulder weakness because of infarction in precentral gyrus has rarely been described. We report an 80-year-old woman with isolated shoulder palsy because of cortical ischemic ...
Bertero G - - 2013
Electrical storm (ES) describes the rapidly clustering ventricular fibrillation (VF) that requires multiple cardioversions. Emerging evidence suggests that Purkinje arborization and sympathetic nerve regeneration play a major role in initiating malignant arrhythmias. We report the case of two patients who, after having survived an acute myocardial infarction (MI), developed repetitive ...
Kumar Harvinder - - 2013
A 38-year-old woman presented with acute onset of severe pain in the left calf and foot after inhaling heroin. On examination, she had distal left lower extremity weakness and absent ankle jerk. EMG at 8 weeks suggested an axonal left sciatic neuropathy. HIV test was negative. Creatine kinase, erythrocyte sedimentation ...
Yim Soo Hwan - - 2013
It is generally thought that the corticobulbar tract descends through the genu of the internal capsule (IC). There have been several reports that genu lesions cause bulbar symptoms such as facial palsies, dysarthria, and dysphagia. However, the precise location of the corticobulbar tract in the IC remains controversial. The purpose ...
Kim Dae-Hyun - - 2013
A 50-year-old woman presented with drowsiness, severe dysarthria, left facial palsy, and left hemiparesis. Diffusion-weighted MRI showed cerebral infarction in the left pontine tegmentum and right cerebellum and angiography revealed basilar artery occlusion. Altered consciousness and hemiparesis fully resolved following successful recananlisation of the basilar artery by emergent intra-arterial thrombolysis. ...
Chen Jian - - 2013
Background: Transplantation of mesenchymal stem cells (MSCs) alters the ventricular electrophysiologic properties after myocardial infarction (MI) in rats. However, it is unclear whether MSCs transplantation enhances the secretion of nerve growth factor (NGF) and affects cardiac sympathetic remodeling. Methods: MI was induced in 35 male Sprague-Dawley rats. Two weeks later, ...
Mao Junfeng J Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha 410008, China. - - 2013
To report a phenomenon of optical nerve atrophy secondary to lateral occipital lobe infarction. Two successive patients with unilateral occipital lobe infarction who experienced bilateral optical nerve atrophy during the follow-up underwent cranial imaging, fundus photography, and campimetry. Each patient was diagnosed with occipital lobe infarction by cranial MRI. During ...
Fu Liang-Wu LW Department of Medicine, School of Medicine, University of California, Irvine, CA 92697, USA. - - 2013
Thinly myelinated Aδ-fiber and unmyelinated C-fiber cardiac sympathetic (spinal) sensory nerve fibers are activated during myocardial ischemia to transmit the sensation of angina pectoris. Although recent observations showed that myocardial ischemia increases the concentrations of opioid peptides and that the stimulation of peripheral opioid receptors inhibits chemically induced visceral and ...
Zhao Ming M Department of Pharmacology, College of Medicine, Xi'an Jiaotong University, No. 76 Yanta West Road, P.O. Box 77#, Xi'an, 710061, People's Republic of - - 2013
Myocardial ischemia/reperfusion (I/R) induces inflammatory response that may lead to remote vascular injury. Vagal nerve elicits the cholinergic anti-inflammatory pathway by activating α7 nicotinic acetylcholine receptors (α7nAChR). Nevertheless, the role of vagal nerve-mediated anti-inflammatory pathway in the vasculature has not been studied previously. Therefore, we aimed to clarify the potential ...
Masuda Hiroki - - 2013
Pseudoperipheral palsy can be caused by cerebral cortical infarctions; however, it is rarely caused by lacunar infarctions, including those in the posterior limb of the internal capsule. Meanwhile, the somatotopic localization of the corticospinal tract in the posterior limb of the internal capsule remains unknown. We herein report the case ...
Lai Tzu-Hsien - - 2012
Purpose:Sporadic hemiplegic migraine is a rare form of migraine associated with motor weakness during the aura phase. While the aura usually lasts less than 1 hour, patients with sporadic hemiplegic migraine frequently have prolonged weakness.  Case Report:A 60-year-old male had sporadic hemiplegic migraine after a head injury at the age ...
Lee Jun Ho - - 2012
Necrotizing fasciitis is a soft tissue infection that is characterized by extensive necrosis of the subcutaneous fat, neurovascular structures, and fascia. Cerebral infarction after facial necrotizing fasciitis has been rarely reported. A 61-year-old woman with diabetes was admitted with painful swelling of her right cheek. One day later, she was ...
Blann A D - - 2012
Aspirin resistance and chronic renal failure are both potentially important clinical issues in coronary artery disease. To test the hypothesis of a relationship between the two, we recruited 169 stable outpatients with proven coronary artery disease (myocardial infarction, coronary artery bypass grafting, intra-coronary stents) taking 75mg aspirin daily. Blood was ...
Chirinos Julio A - - 2012
Myocardial and arterial load are time-varying phenomena. Despite their importance in myocardial function, the arterial properties that determine time-resolved myocardial wall stress are unknown. We aimed to assess arterial properties as determinants of time-resolved myocardial stress among 1214 men and women enrolled in the Asklepios Study. Time-resolved central pressure, flow, ...
Rolandi M Cristina - - 2012
Our aim was to investigate the effect of altered cardiac-coronary interaction during the Valsalva manoeuvre (VM) on coronary wave intensity and the response of coronary microvascular resistance. In 13 patients, left ventricular (P(LV)) and aortic pressure were measured during catheterization, together with intracoronary pressure and blood flow velocity (U) via ...
Guiraudon Gérard M - - 2012
We report the first use of a new platform, the Guiraudon Universal Cardiac Introducer (GUCI), in humans for accessing the left atrium for catheter-based ablations in patients with resistant atrial arrhythmias after total cavopulmonary derivation. The GUCI was originally designed for intracardiac access for closed, beating instrumental intracardiac surgery.The patient ...
Shanmugasundaram Madhan - - 2012
BACKGROUND: In out-of-hospital cardiac arrest (OHCA) due to ventricular fibrillation (VF), VF may recur during resuscitation (recurrent VF) or fail to defibrillate (shock-resistant VF). While retrospective studies have suggested that amplitude spectral area (AMSA) and slope predict defibrillation, it is unknown whether the predictive power is influenced by VF type. ...
Yong Andy S C - - 2012
BACKGROUND: Recent studies show that coronary microcirculatory impairment is an independent predictor of poor outcomes in patients with cardiovascular disease. However, controversy exists over whether microcirculatory resistance, a measure of coronary microcirculatory status, is dependent on epicardial stenosis severity. Previous studies demonstrating that microcirculatory resistance is dependent on epicardial stenosis ...
Layland Jamie - - 2012
We present a case of takotsubo cardiomyopathy and demonstrate an initial elevation of microcirculatory resistance (IMR) that reduced on follow-up evaluation. This corresponded with improvements in left ventricular function. We postulate that the changes in microvascular resistance reflect favourable left ventricular microvascular remodelling. The measurement of IMR, a novel marker ...
Spoto Belinda - - 2011
BACKGROUND: Left ventricular hypertrophy (LVH) is a major cardiovascular (CV) complication in patients with kidney failure, and an association between polymorphisms in the ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) gene, a genetic marker of insulin resistance, and LVH and Left ventricular (LV) concentric remodelling has been recently documented in these patients.Aims. Since ...
Westaby Stephen - - 2011
Ischemic cardiogenic shock is a complex, self-perpetuating pathological process that frequently causes death irrespective of medical therapy. Early definition of coronary anatomy is a pivotal step towards survival. Those destined to develop shock are likely to have three-vessel or left main stem disease with previously impaired left ventricular function. Early ...
Wańkowicz Zofia - - 2011
Diuretic-resistant congestive heart failure in the form of type 2 cardiorenal syndrome is a problem of growing significance in everyday clinical practice because of high morbidity and mortality. There has been scant progress in the treatment of overhydration, the main cause of symptoms in this group of patients. The aim ...
Childers Rory - - 2011
The repolarizing T(a) wave of normal sinus rhythm is not fully visible unless there is a long P-R interval or complete atrioventicular block. Even with the latter, it is often of unseeably low voltage. It can powerfully influence inferior lead ST deviation in the stress test. The T(a) of inverted ...
Hlivák Peter - - 2011
Catheter Ablation of Idiopathic Ventricular Tachycardia. We present a 34-year-old woman with idiopathic ventricular tachycardia that resisted 2 previous attempts for catheter ablation and was successfully ablated in the myocardial extension within the noncoronary aortic cusp. (J Cardiovasc Electrophysiol, Vol. pp. 1-4).
Hershenson Jared A - - 2011
Myocardial abscess perforation is an extremely rare complication of infective endocarditis. We present a case of a 12-month-old infant who developed community-associated methicillin-resistant Staphylococcus aureus bacteremia after an incision and drainage of a skin abscess. He subsequently developed septic emboli to the brain and lungs, and a myocardial cavity in ...
Kim Hyun Joo - - 2011
We performed a prospective cohort trial on 220 patients undergoing elective off-pump coronary artery bypass surgery and taking aspirin to evaluate the effect of aspirin resistance on myocardial injury. The patients were divided into aspirin responders and aspirin non-responders by the value of the aspirin reaction units obtained preoperatively using ...
Richter S - - 2011
In a 63-year-old woman, several capture beats were documented during a slow, right bundle-branch block tachycardia. These occur whenever retrograde conduction is lacking due to ventriculoatrial Wenckebach block. The 12-lead electrocardiogram suggested a ventricular origin in the area of the left posterior papillary muscle which was confirmed by endocardial activation ...
Pandozi Claudio - - 2011
Radiofrequency ablation procedures inside the left atrial appendage (LAA) are likely to involve dangerous complications because of a high thrombogenic effect. Cryoablation procedures are supposed to be safer. We describe two cases of successful cryoablation procedures. Two NavX-guided cryoablations of permanent focal atrial arrhythmias arising from the LAA were performed. ...
Yang Ya - - 2010
Homozygous familial hypercholesterolemia (HoFH) is a rare disorder characterized by the early onset of atherosclerosis and usually occurs at the ostia of coronary arteries. In this study, we used transthoracic Doppler echocardiography (TTDE) to evaluate the dynamic changes of coronary flow in HoFH patients and to detect aortic and coronary ...
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