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Blackburn Nick J R NJ Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa K1Y 4W7, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa K1H 8M5, - - 2014
Injectable hydrogel biomaterials are promising therapies to promote repair and regeneration post-myocardial infarction (MI). However, the timing of delivery and the mechanisms through which biomaterial treatments confer their benefits are translational issues that remain to be addressed. We assessed the efficacy of an injectable collagen matrix at 3 different delivery ...
Li Jianping J From the Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, - - 2014
Estrogen regulation of myocardial chymase and chymase effects on cardiac remodeling are unknown. To test the hypothesis that estrogen prevents pressure overload-induced adverse cardiac remodeling by inhibiting mast cell (MC) chymase release, transverse aortic constriction or sham surgery was performed in 7-week-old intact and ovariectomized (OVX) rats. Three days before ...
Pang Xue-Fen XF Department of Physiology, Shanxi Medical University, Taiyuan, Shanxi, - - 2014
Curcumin has been shown to improve cardiac function by reducing degradation of extracellular matrix and inhibiting synthesis of collagen after ischemia. This study tested the hypothesis that attenuation of maladaptive cardiac repair with curcumin is associated with a dual ACE-inhibition and angiotensin II AT1 receptor antagonism after myocardial infarction. Sprague-Dawley ...
Fukui Miho M Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, - - 2014
While beta blockade improves left ventricular (LV) function in patients with chronic heart failure (CHF), the mechanisms are not well known. This study aimed to examine whether changes in myocardial collagen metabolism account for LV functional recovery following beta-blocker therapy in 62 CHF patients with reduced ejection fraction (EF). LV ...
Qa'aty Nour N Physiology & Experimental Medicine Program, Heart Center, Hospital for Sick Children, ON, - - 2014
Glucagon-like peptide 1 (GLP-1) is a metabolic hormone involved in the stimulation of insulin biosynthesis and secretion. It has been recently reported that GLP-1 also exerts cardioprotective effects and facilitates functional recovery after myocardial infarction through GLP-1 receptor-mediated signaling in cardiomyocytes. GLP-1 treatment has been also demonstrated to produce sustained ...
Betge Stefan S Department of Internal Medicine I, Division of Cardiology, Friedrich Schiller University, Jena, Thuringia 07740, - - 2014
Tranilast (Tra) reduces intracardiac interstitial fibrosis in the animal models of hypertensive heart failure and diabetic cardiomyopathy by inhibiting cardiac fibroblasts. The present study examined whether Tra has long-term effects on the cardiac remodeling in the remote area of the left ventricle (LV) following myocardial infarction (MI) in the rat. ...
Nikitovic Dragana - - 2014
The mechanisms of anthracycline-dependent cardiotoxicity have been studied widely, with the suggested principal mechanism of anthracycline damage being the generation of reactive oxygen species by iron-anthracycline complexes, leading to lipid peroxidation and membrane damage. An increasing number of researchers studying cardiovascular events associated with anthracycline-based chemotherapy are addressing cardiac extracellular ...
Wang Weijie W Department of Cardiology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, P.R. China ; Department of ICU, People's Hospital of Rizhao, Rizhao, Shandong 276826, P.R. - - 2015
The present study aimed to investigate the effect of rosuvastatin on atrial structural remodeling in rabbits with myocardial infarction (MI). The rabbits were randomly divided into 4 groups: The sham operation group (S; n=8), the MI group (MI; n=7), the group with low-dose rosuvastatin [Rs; 2.5 mg/(kg/d), n=7] and the ...
Aus dem Siepen Fabian F Department of Cardiology, Angiology and Pneumology, University Hospital Heidelberg, Im Neuenheimer Feld 410, Heidelberg 69120, - - 2014
The aim of this study was to determine the value of extracellular volume fraction (ECV) for the non-invasive assessment of diffuse myocardial fibrosis (MF) in different stages of systolic left ventricular (LV) dysfunction in dilated cardiomyopathy (DCM) in comparison with endomyocardial biopsy. Non-invasive ECV assessment using cardiovascular magnetic resonance (CMR) ...
Gupta A A Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, - - 2014
We have previously shown rapid reversal of left ventricular hypertrophy (LVH) with 6 months of spironolactone therapy in patients with resistant hypertension (HTN), preserved left ventricular ejection fraction and no history of heart failure. In this substudy, we investigated the effect of mineralocorticoid receptor blockade with spironolactone on pre-clinical diastolic ...
Wang Chih-Hsien CH Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan Department of Surgery, National Taiwan University Hospital, Hsin-Chu Branch, Hsin-Chu, - - 2014
Our team demonstrated in the past that pyridoxamine attenuated arterial stiffening by targeting the pathogenic formation of glycated collagen cross-links in aged rats. Herein, we examined whether pyridoxamine therapy can protect against mechanical defects in myocardial relaxation by improving arterial wave properties and cardiac contractile performance in senescence animals. Fifteen-month-old ...
Sun Lili L Department of Emergency Medicine, Beijing Jishuitan Hospital, Beijing 100035, - - 2014
The study was designed to explore the role of hydrogen sulfide (H2S) in the regulation of myocardial collagen remodeling in spontaneously hypertensive rats (SHRs) and its possible mechanisms. We treated nine-week-old male SHRs and age- and sex-matched Wistar-Kyoto rats (WKYs) with NaHS (90 μmol·kg(-1)·day(-1)) for 9 weeks. At 18 weeks, ...
Abdullah Osama M OM Department of Bioengineering, University of Utah, Salt Lake City, UT, - - 2014
Non-invasive imaging techniques are highly desirable as an alternative to conventional biopsy for the characterization of the remodeling of tissues associated with disease progression, including end-stage heart failure. Cardiac diffusion tensor imaging (DTI) has become an established method for the characterization of myocardial microstructure. However, the relationships between diffuse myocardial ...
Ding Wen-Xiao WX 1 Department of Respiratory Medicine, 2 Department of Cardiothoracic Surgery, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China ; 3 Department of Respiratory Diseases, Jiangsu Geriatric Hospital, Nanjing 210024, - - 2014
Obstructive sleep apnea syndrome (OSAS) is associated with many cardiovascular disorders. Chronic intermittent hypoxia (CIH) is the primary player in OSAS of the many associated factors. This study was in order to investigate the effects of the Adiponectin (Ad) on left ventricular remodeling induced by CIH. Forty-five rats were randomly ...
Engebretsen Kristin V KV Department of Cardiothoracic Surgery, Oslo University Hospital Ullevål, Oslo, Norway; Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway; KG Jebsen Cardiac Research Center and Center for Heart Failure Research, Oslo, - - 2014
Pressure overload-induced TGF-β signaling activates cardiac fibroblasts (CFB) and leads to increased extracellular matrix (ECM) protein synthesis including fibrosis. Excessive ECM accumulation may in turn affect cardiac function contributing to development of heart failure. The aim of this study was to examine the effects of SM16, an orally active small ...
Liu Chang C Division of Cardiac Surgery, Department of Surgery, The First Affiliate Hospital of Harbin Medical University, Harbin, - - 2014
Cardiac repair and remodeling occur following myocardial infarction (MI). Our previous study demonstrated that platelet-derived growth factor (PDGF)-A/-D and PDGF receptors (PDGFR) are increased in the infarcted heart, with cells expressing PDGFR primarily endothelial and fibroblast-like cells. In the present study, we tested the hypothesis that PDGF contributes to cardiac angiogenesis ...
Yin Yi-Gang YG Cardiovascular Institute, People's Hospital of Taizhou, Taizhou 235000, - - 2014
To study the effects of phentolamine on myocardial extracellular matrix of cardiac remodeling induced by norepinephrine in rats. 24 SD rats were divided into 3 groups randomly: control groups, norepinephrine groups (model groups), norepinephrine +phentolamine groups (treatment groups). Echocardiography was used to detect changes in cardiac structure and function, the ...
Huemer Martin M Department of Cardiology, Charité - University Medicine Berlin, Campus Virchow-Klinikum, Berlin, - - 2014
Catheter ablation of atrial fibrillation has been associated with left-sided phrenic nerve palsy. Knowledge of the individual left phrenic nerve course therefore is essential to prevent nerve injury. The aim of this study was to test the feasibility of an intraprocedural pace mapping and reconstruction of the left phrenic nerve ...
Lee Seung-Jae SJ Department of Neurology, Sejong General Hospital, Bucheon, South - - 2014
Cerebral infarct related to varicella-zoster virus (VZV) has been reported in the literature. In addition, lateral medullary infarct (LMI) can be manifested rarely as isolated gait ataxia without other characteristic symptoms. A 70-year-old female was admitted to our hospital because of herpes zoster on the right trigeminal nerve distribution. On ...
Saburkina Inga I Institute of Anatomy, Faculty of Medicine, Lithuanian University of Health Sciences, Kaunas, - - 2014
Although the rabbit is routinely used as the animal model of choice to investigate cardiac electrophysiology, the neuroanatomy of the rabbit heart is not well documented. The aim of this study was to examine the topography of the intrinsic nerve plexus located on the rabbit heart surface and interatrial septum ...
Guo Zheng Z Department of Anesthesiology, Shanxi Medical University and Second Hospital of Shanxi Medical University, 56 Xinjian Nan Road, Taiyuan 030001, Shanxi, China; Key Laboratory of Cellular Physiology (Shanxi Medical University), National Education Commission. Electronic address: - - 2014
Nerve growth factor (NGF) plays important roles in transmission of nociception, neural innervation and survival in sympathetic and sensory neurons. Evidence indicates that NGF may sensitize the sensory and sympathetic reaction upon noxious stimulation. Understanding of the alterations of NGF in the sensory neurons during acute myocardial infarction and the ...
Li Xiaodi X Department of Neurology, Guangdong 999 Brain Hospital, Shatai Road, 578, Guangzhou, 510510, - - 2014
Here, we present a rare case of a lateral medullary infarction with ipsilateral hemiparesis, lemniscal sensation loss and hypoglossal nerve palsy. In this case, we proved Opalski's hypothesis by diffusion tensor tractography that ipsilateral hemiparesis in a medullary infarction is due to the involvement of the decussated corticospinal tract. We ...
Nicholson Luke L Department of Ophthalmology, Singleton Hospital, Swansea, Wales, - - 2014
We present a rare case of unilateral lateral rectus palsy following an elective coronary angiography and percutaneous coronary intervention in a 78-year-oldwoman. Ophthalmoplegia following coronary angiography is extremely rare and this is the first case of a unilateral lateral rectus palsy following the procedure.
Chowdhury Tumul T 0000-0002-8946-4148 Department of Anesthesia and Perioperative Medicine, Health Sciences Center, University of Manitoba, 671 William Avenue, Winnipeg, Canada R3E - - 2014
Background. Coronary artery spasm (CAS) is a rarely reported complication in neurosurgical patients and its main causative mechanism was attributed to vagal mediated responses. However, these may be the unusual manifestations of trigeminal cardiac reflex (TCR) which is a well established brain stem reflex observed in various neurosurgical patients. Methods ...
Zhou Hao H Department of Cardiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China. - - 2014
Scutellarin (SCU) is the major active component of breviscapine and has been reported to be capable of decreasing myocardial fibrosis. The aim of the present study is to investigate whether SCU treatment attenuates isoprenaline-induced myocardial fibrosis and the mechanisms of its action. Rats were injected subcutaneously with isoprenaline (Iso) to ...
Hundae Aneley A Baylor University Medical Center, Baylor Heart and Vascular Institute, Baylor Jack and Jane Hamilton Heart and Vascular Hospital, Dallas, Tex., - - 2014
In recent years, there has been considerable interest in cellular and tissue responses to injury that result in the deposition of extracellular matrix, collagen, elastic fibers, and the histopathological development of fibrosis. In the myocardium, fibrosis results in many recognizable clinical features, including PR interval prolongation, heart block, bundle branch ...
Sun Juan J Clinical Postdoctoral Research Station, The First Affiliated Hospital of Xinjiang Medical University, Urumuqi, China - - 2014
Background The aim of this study was the establishment of a rapid atrial pacing (RAP)-induced atrial fibrillation (AF) model with electrophotoluminescence and the application of ultrasonic backscatter quantitative analysis of the degree of myocardial fibrosis in New Zealand white rabbits. Material and Methods Sixteen New Zealand white rabbits were randomly ...
Alves Jadson P JP Laboratory of Physiology, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, Rio Grande do Sul, - - 2014
The role of resistance training on collagen deposition, the inflammatory profile and muscle weakness in heart failure remains unclear. Therefore, this study evaluated the influence of a resistance training program on hemodynamic function, maximum strength gain, collagen deposition and inflammatory profile in chronic heart failure rats. Thirty-two male Wistar rats ...
Jia Yin-Yu YY Department of Cardiology, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, - - 2013
Aliskiren is an oral renin inhibitor, which inhibits the first rate limiting step in the renin angiotensin aldosterone system. In this study, sympathetic nerve sprouting and the inducibility of ventricular fibrillation after aliskiren treatment in myocardial infarction were investigated. Male Sprague Dawley rats after coronary artery ligation were randomly allocated ...
Dehlin Heather M - - 2013
The tachykinin, substance P, is found primarily in sensory nerves. In the heart, substance P-containing nerve fibers are often found surrounding coronary vessels, making them ideally situated to sense changes in the myocardial environment. Recent studies in rodents have identified substance P as having dual roles in the heart, depending ...
Piccirillo Gianfranco - - 2013
Evidence from a canine experimental acute myocardial infarction (MI) model shows that until the seventh week after MI the relationship between stellate ganglionic nerve and vagal nerve activities (SGNA/VNA) progressively increases. We evaluated how autonomic nervous system activity influences temporal myocardial repolarization dispersion at this period. We analyzed autonomic nerve ...
Zhang Fengxiang - - 2013
Neural remodeling after myocardial infarction (MI) may cause malignant ventricular arrhythmia, which is the main cause of sudden cardiac death following MI. Herein, we aimed to examine whether iPSc transplantation can ameliorate neural remodeling and reduce ventricular arrhythmias (VA) in a post-infarcted swine model. Left anterior descending coronary arteries were ...
Ng G Andre - - 2013
Sudden cardiac death remains a significant unresolved clinical problem with many of the deaths due to malignant ventricular arrhythmias. Markers of abnormal autonomic function have been shown to be strong prognostic predictors highlighting the important relationship between reduced vagal tone and malignant ventricular arrhythmias such as ventricular fibrillation in cardiac ...
Kawasaki Akiko - - 2013
Clinicoradiological correlations observed in patients with small cortical infarctions have supported somatotopic representation of different parts of body areas in primary motor cortex. However, isolated shoulder weakness because of infarction in precentral gyrus has rarely been described. We report an 80-year-old woman with isolated shoulder palsy because of cortical ischemic ...
Bertero G - - 2013
Electrical storm (ES) describes the rapidly clustering ventricular fibrillation (VF) that requires multiple cardioversions. Emerging evidence suggests that Purkinje arborization and sympathetic nerve regeneration play a major role in initiating malignant arrhythmias. We report the case of two patients who, after having survived an acute myocardial infarction (MI), developed repetitive ...
Kumar Harvinder - - 2013
A 38-year-old woman presented with acute onset of severe pain in the left calf and foot after inhaling heroin. On examination, she had distal left lower extremity weakness and absent ankle jerk. EMG at 8 weeks suggested an axonal left sciatic neuropathy. HIV test was negative. Creatine kinase, erythrocyte sedimentation ...
Yim Soo Hwan - - 2013
It is generally thought that the corticobulbar tract descends through the genu of the internal capsule (IC). There have been several reports that genu lesions cause bulbar symptoms such as facial palsies, dysarthria, and dysphagia. However, the precise location of the corticobulbar tract in the IC remains controversial. The purpose ...
Kim Dae-Hyun - - 2013
A 50-year-old woman presented with drowsiness, severe dysarthria, left facial palsy, and left hemiparesis. Diffusion-weighted MRI showed cerebral infarction in the left pontine tegmentum and right cerebellum and angiography revealed basilar artery occlusion. Altered consciousness and hemiparesis fully resolved following successful recananlisation of the basilar artery by emergent intra-arterial thrombolysis. ...
Chen Jian - - 2013
Background: Transplantation of mesenchymal stem cells (MSCs) alters the ventricular electrophysiologic properties after myocardial infarction (MI) in rats. However, it is unclear whether MSCs transplantation enhances the secretion of nerve growth factor (NGF) and affects cardiac sympathetic remodeling. Methods: MI was induced in 35 male Sprague-Dawley rats. Two weeks later, ...
Mao Junfeng J Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha 410008, China. - - 2013
To report a phenomenon of optical nerve atrophy secondary to lateral occipital lobe infarction. Two successive patients with unilateral occipital lobe infarction who experienced bilateral optical nerve atrophy during the follow-up underwent cranial imaging, fundus photography, and campimetry. Each patient was diagnosed with occipital lobe infarction by cranial MRI. During ...
Fu Liang-Wu LW Department of Medicine, School of Medicine, University of California, Irvine, CA 92697, USA. - - 2013
Thinly myelinated Aδ-fiber and unmyelinated C-fiber cardiac sympathetic (spinal) sensory nerve fibers are activated during myocardial ischemia to transmit the sensation of angina pectoris. Although recent observations showed that myocardial ischemia increases the concentrations of opioid peptides and that the stimulation of peripheral opioid receptors inhibits chemically induced visceral and ...
Zhao Ming M Department of Pharmacology, College of Medicine, Xi'an Jiaotong University, No. 76 Yanta West Road, P.O. Box 77#, Xi'an, 710061, People's Republic of - - 2013
Myocardial ischemia/reperfusion (I/R) induces inflammatory response that may lead to remote vascular injury. Vagal nerve elicits the cholinergic anti-inflammatory pathway by activating α7 nicotinic acetylcholine receptors (α7nAChR). Nevertheless, the role of vagal nerve-mediated anti-inflammatory pathway in the vasculature has not been studied previously. Therefore, we aimed to clarify the potential ...
Masuda Hiroki - - 2013
Pseudoperipheral palsy can be caused by cerebral cortical infarctions; however, it is rarely caused by lacunar infarctions, including those in the posterior limb of the internal capsule. Meanwhile, the somatotopic localization of the corticospinal tract in the posterior limb of the internal capsule remains unknown. We herein report the case ...
Lai Tzu-Hsien - - 2012
Purpose:Sporadic hemiplegic migraine is a rare form of migraine associated with motor weakness during the aura phase. While the aura usually lasts less than 1 hour, patients with sporadic hemiplegic migraine frequently have prolonged weakness.  Case Report:A 60-year-old male had sporadic hemiplegic migraine after a head injury at the age ...
Lee Jun Ho - - 2012
Necrotizing fasciitis is a soft tissue infection that is characterized by extensive necrosis of the subcutaneous fat, neurovascular structures, and fascia. Cerebral infarction after facial necrotizing fasciitis has been rarely reported. A 61-year-old woman with diabetes was admitted with painful swelling of her right cheek. One day later, she was ...
Blann A D - - 2012
Aspirin resistance and chronic renal failure are both potentially important clinical issues in coronary artery disease. To test the hypothesis of a relationship between the two, we recruited 169 stable outpatients with proven coronary artery disease (myocardial infarction, coronary artery bypass grafting, intra-coronary stents) taking 75mg aspirin daily. Blood was ...
Chirinos Julio A - - 2012
Myocardial and arterial load are time-varying phenomena. Despite their importance in myocardial function, the arterial properties that determine time-resolved myocardial wall stress are unknown. We aimed to assess arterial properties as determinants of time-resolved myocardial stress among 1214 men and women enrolled in the Asklepios Study. Time-resolved central pressure, flow, ...
Rolandi M Cristina - - 2012
Our aim was to investigate the effect of altered cardiac-coronary interaction during the Valsalva manoeuvre (VM) on coronary wave intensity and the response of coronary microvascular resistance. In 13 patients, left ventricular (P(LV)) and aortic pressure were measured during catheterization, together with intracoronary pressure and blood flow velocity (U) via ...
Guiraudon Gérard M - - 2012
We report the first use of a new platform, the Guiraudon Universal Cardiac Introducer (GUCI), in humans for accessing the left atrium for catheter-based ablations in patients with resistant atrial arrhythmias after total cavopulmonary derivation. The GUCI was originally designed for intracardiac access for closed, beating instrumental intracardiac surgery.The patient ...
Shanmugasundaram Madhan - - 2012
BACKGROUND: In out-of-hospital cardiac arrest (OHCA) due to ventricular fibrillation (VF), VF may recur during resuscitation (recurrent VF) or fail to defibrillate (shock-resistant VF). While retrospective studies have suggested that amplitude spectral area (AMSA) and slope predict defibrillation, it is unknown whether the predictive power is influenced by VF type. ...
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