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Dhar Ranjana R 1Department of Paediatric Cardiology,Our Lady's Hospital for Sick - - 2014
We report a baby girl with an antenatal diagnosis of biventricular non-compaction and complete heart block detected at 22 weeks' gestation. Postnatal echocardiography confirmed severe biventricular non-compaction hypertrophic cardiomyopathy, multiple muscular ventricular septal defects, and mild-moderate pulmonary valve stenosis. Skeletal muscle biopsy confirmed complex 1 mitochondrial respiratory chain deficiency. An ...
O'Meara Eileen E Montreal Heart Institute, Université de Montréal, Montreal, Canada - - 2014
-Anemia is a highly prevalent and strong independent prognostic marker in heart failure (HF), yet this association is not completely understood. Whether anemia is simply a marker of disease severity and concomitant chronic kidney disease (CKD) or represents the activation of other detrimental pathways remains uncertain. We sought to determine ...
Cho In-Jeong IJ Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, - - 2014
There are few data on the effects of low hemoglobin levels on the left ventricle (LV) in patients without heart disease. The objective of this study was to document changes in the echocardiographic variables of LV structure and function after the correction of anemia without significant cardiovascular disease. In total, ...
Cohen-Solal Alain A Department of Cardiology, Lariboisière Hospital, AP-HP, Paris, - - 2014
In patients with heart failure, iron deficiency is frequent but overlooked, with a prevalence of 30%-50%. Since it contributes to cardiac and peripheral muscle dysfunction, iron deficiency is associated with poorer clinical outcomes and a greater risk of death, independent of haemoglobin level. Therefore, iron deficiency emerges as a new ...
Diez Emiliano Raúl ER Institute of Medical and Experimental Biology of Cuyo, National Scientific and Technical Research Council, Mendoza, Argentina - - 2014
Cardiovascular disease is often associated with chronic kidney disease and vice versa; myocardial vitamin D receptors (VDRs) are among the probable links between the 2 disorders. The vitamin D receptor activator paricalcitol protects against some renal and cardiovascular complications. However, the structural and electrophysiological effects of myocardial vitamin D receptor ...
Champion Sébastien S Réanimation médicale et toxicologique, Hôpital Lariboisière, Paris, - - 2014
We report a case of a fatal massive anterior acute myocardial infarction (AMI) after administration of vitamin K1 for over-anticoagulation following cardioembolism from mechanical mitroaortic valve prostheses associated with atrial fibrillation.
Verdoia Monica M Department of Cardiology, Ospedale "Maggiore della Carità", Eastern Piedmont University, Novara, - - 2014
Vitamin D (25-OH D3) deficiency represents a rising social and economic problem in Western countries. Vitamin D has been recently reported to modulate inflammatory processes, endothelium and smooth muscle cell proliferation and even platelet function, thus potentially modulating atherothrombosis. Great interest has been addressed on its impact on cardiovascular outcome, ...
Ahmed Mavra M Keenan Research Centre of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada, - - 2014
The management of heart failure (HF) represents a significant challenge for both patients as well as the healthcare system in industrialized countries. Thiamin is a required coenzyme in the energy-producing reactions that fuel myocardial contraction. Therefore, thiamin deficiency (TD) may contribute to myocardial weakness by limiting the energy available for ...
Welles Christine C - - 2014
A growing body of evidence supports an association between vitamin D and cardiovascular disease. However, the mechanisms underlying this association are unknown. From 2000 to 2002, we identified 946 participants with stable cardiovascular disease in San Francisco, California, and followed them prospectively for cardiovascular events (heart failure, myocardial infarction, stroke, ...
Gv Shashikala S Assistant Professor, Department of Physiology, S. Nijalingappa Medical College and HSK Hospital , Bagalkot, India - - 2014
Anaemia affects the body by decreased oxygen (O2) carrying capacity of the blood. There is growing evidence that anaemia contributes to cardiac disease and death. It causes O2 supply - demand myocardial mismatch causing myocardial ischemia. There is diversity of opinion available in literature on reports of electrocardiographic (ECG) changes ...
Dorsch Michael P MP 1Department of Pharmacy Services, University of Michigan Health System, Ann Arbor, Michigan, - - 2014
Introduction:Vitamin D deficiency has been associated with the development of myocardial hypertrophy and inflammation. These findings suggest that vitamin D status and vitamin D receptor (VDR) genomics may play a role in myocardial fibrosis. The aim of this pilot study was to determine the association between vitamin D levels, VDR ...
Chen Yan Y Division of Cardiology, Department of Medicine, the University of Hong Kong, Queen Mary Hospital, Hong Kong, - - 2014
The underlying mechanism of myocardial dysfunction in patients with type 2 diabetes mellitus (T2DM) is unclear. Nonetheless recent studies have revealed that vitamin D (vit-D) deficiency, which is prevalent in such patients, is associated with adverse cardiovascular events. We hypothesized that vit-D deficiency in patients with T2DM may contribute to ...
Takahashi Makiko M Department of Anatomy and Cell Biology, Graduate School of Medicine, Osaka City University, Osaka 545-8585, Japan; Department of Legal Medicine, Graduate School of Medicine, Osaka University, Osaka 565-0871, - - 2014
The epicardium, which is derived from the proepicardial organ (PE) as the third epithelial layer of the developing heart, is crucial for ventricular morphogenesis. An epicardial deficiency leads to a thin compact layer for the developing ventricle; however, the mechanisms leading to the impaired development of the compact layer are ...
Allison Richard J RJ National Sports Medicine Program, ASPETAR, Qatar Orthopaedic and Sports Medicine Hospital, - - 2014
Vitamin D (25(OH)D) deficiency has associations with bowl/colon cancer, arthritis, diabetes, and cardiovascular disease. Many athletes are vitamin D deficient, yet no studies have examined the association between 25(OH)D status and cardiac structure and function in healthy athletes. A total of 506 national-level athletes [football (50%), handball (23%), volleyball (16%), ...
Kumar Gaurav G Queensland Paediatric Cardiac Service, Mater Children's Hospital, Brisbane, - - 2014
We report a neonate with medium chain acyl-coenzyme A dehydrogenase deficiency (MCAD) who had a cardiac arrest due to ventricular tachycardia and fibrillation. Extracorporeal life support (ECLS) was deployed, from which the baby was subsequently separated and discharged from hospital. This case was a rare neonatal presentation of MCAD and ...
Palmer Barry R BR Christchurch Heart Institute, Department of Medicine, University of Otago, Christchurch, New Zealand; Genetics Otago, University of Otago, Christchurch, New Zealand; Institute of Food, Nutrition & Human Health, Massey University, Wellington, New - - 2014
The methylene-tetrahydrofolate dehydrogenase (NADP+ dependent) 1-like (MTHFD1L) gene is involved in mitochondrial tetrahydrofolate metabolism. Polymorphisms in MTHFD1L, including rs6922269, have been implicated in risk for coronary artery disease (CAD). We investigated the association between rs6922269 and known metabolic risk factors and survival in two independent cohorts of coronary heart disease ...
Misumida Naoki N Department of Cardiology, Toyota Memorial Hospital, 1-1 Heiwa-cho, Toyota 471-8513, Japan ; Department of Medicine, Mount Sinai Beth Israel, First Avenue at 16th Street, New York, NY 10003, - - 2014
Previous studies have suggested that diuretic therapy for heart failure may lead to thiamine deficiency due to the increased urinary thiamine excretion. Herein, we present the case of a 61-year-old man with shoshin beriberi, a fulminant form of wet beriberi, induced by long-term diuretic therapy. The patient had a history ...
Huang Ching-Hui CH Division of Cardiology, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan; Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, - - 2014
Anemia is associated with high mortality and poor prognosis after acute coronary syndrome (ACS). Increased red cell distribution width (RDW) is a strong independent predictor for adverse outcomes in ACS. The common underlying mechanism for anemia and increased RDW value is iron deficiency. It is not clear whether serum iron ...
Zhong Ya Y Department of Geratology, Zhongnan Hospital of Wuhan University, Wuhan 430071, - - 2014
Ventricular arrhythmia (VA) is one of the most common complications of myocardial infarction (MI), and ventricular tachycardia and fibrillation are the main causes for sudden cardiac death. This study aimed to explore the effect of ramipril on the occurrence of VA and its mechanism after MI in rabbits. Twenty-four New ...
Qaseem Amir - - 2013
The American College of Physicians (ACP) developed this guideline to present the evidence and provide clinical recommendations on the treatment of anemia and iron deficiency in adult patients with heart disease. This guideline is based on published literature in the English language on anemia and iron deficiency from 1947 to ...
Kepez A - - 2013
Anemia and chronic renal failure (CRF) are frequent comorbidities in patients with heart failure (HF), and they have been reported to be associated with increased mortality and hospitalization rates. HF, anemia, and CRF have been reported to interact with each other forming a vicious cycle termed cardio-renal-anemia syndrome. The aim ...
Gil Victor M - - 2013
Heart failure is a common problem and a major cause of mortality, morbidity and impaired quality of life. Anemia is a frequent comorbidity in heart failure and further worsens prognosis and disability. Regardless of anemia status, iron deficiency is a common and usually unidentified problem in patients with heart failure. ...
Meredith Anna J - - 2013
Evidence linking vitamin D to cardiovascular (CV) health has accumulated in recent years: numerous epidemiologic studies report deficiency as a significant CV risk factor, and rodent models suggest that active vitamin D can modulate critical remodeling processes, including cardiac hypertrophy and extracellular matrix remodeling. The presence of vitamin D signaling ...
Kim Ho Jeong - - 2013
To investigate the correlation between visuospatial neglect and anemia in patients with right cerebral infarction, as well as to identify the risk factor of neglect and furnish preliminary data on rehabilitation management. The line bisection test and Albert test were conducted on subjects with right cerebral infarction in order to ...
Steinvil Arie - - 2013
Anemia and inflammation are both associated with unfavorable outcomes in patients with ischemic heart disease and might be pathophysiologically linked. We aimed to analyze the additive value of anemia and inflammation on the outcomes of patients undergoing percutaneous coronary intervention. Cox regression models were fitted for hemoglobin and C-reactive protein ...
Dinicolantonio James J - - 2013
A systematic review of the literature was performed by searching Pubmed and EMBASE databases using the terms "thiamine," "vitamin B1," "heart failure," "systolic dysfunction," "ventricular dysfunction," "cardiomyopathy," "ventricular failure," and "systolic failure." Relevant trials and articles were evaluated pertaining to thiamine deficiency in patients with heart failure (HF) and references ...
Lee Ji-Hye - - 2013
As a rare cerebrovascular disease, cerebral venous thrombosis (CVT) is caused by various conditions including trauma, infection, oral contraceptive, cancer and hematologic disorders. However, iron deficiency anemia is not a common cause for CVT in adult. Posterior fossa infarction following CVT is not well demonstrated because posterior fossa has abundant ...
Kaya Zekeriya - - 2013
Contrary effects of vitamin B12 deficiency have been shown on the cardiovascular system. Aim of our study was to analyze left ventricular (LV) myocardial deformation, by use of two dimensional (2D) speckle tracking echocardiography (STE) in patients with vitamin B12 deficiency and normal LV ejection fraction. : METHODS: Twenty-five patients ...
Akaishi Makoto - - 2013
To assess effects of long-term anemia management on left ventricular hypertrophy in patients with chronic kidney disease (CKD) not on dialysis, we performed secondary outcome analyses of a randomized controlled study that evaluated effects of anemia management with erythropoiesis stimulating agents in this population. Subjects [hemoglobin (Hb)<10.0g/dL, 2.0≤serum creatinine<6.0mg/dL] were ...
Goleniewska Beata MaƂgorzata - - 2013
OBJECTIVES: The study aimed to examine the relationship between vitamin D levels and the extent of coronary stenotic lesions in patients with ST-segment elevation myocardial infarction (STEMI). BACKGROUND: Experimental evidence points to the involvement of multiple factors in coronary plaque formation, including vitamin D. Little is known, however, about the ...
Camici Marcello - - 2013
The authors briefly review the biological effects of vitamin D on the heart and discuss the experimental and clinical studies related to the potential protective effect of vitamin D on the cardiovascular system. Experimental and observational studies in man strongly suggest that vitamin D supplementation can benefit heart failure patients ...
Bae Soochan S Cardiovascular Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, - - 2013
Accumulating evidence suggests that vitamin D deficiency plays a crucial role in heart failure. However, whether vitamin D signaling itself plays an important role in cardioprotection is poorly understood. In this study, we examined the mechanism of modulating vitamin D signaling on progression to heart failure after myocardial infarction (MI) ...
Chang Jer-Ming - - 2013
BACKGROUND:: Anemia is a common complication in patients with chronic kidney disease (CKD), which may initiate or accelerate left ventricular hypertrophy (LVH). This study is designed to assess whether the coexistence of anemia and LVH is independently associated with the rate of renal function decline and increased cardiovascular events in ...
Lygate Craig A CA Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, UK. - - 2013
Creatine is thought to be involved in the spatial and temporal buffering of ATP in energetic organs such as heart and skeletal muscle. Creatine depletion affects force generation during maximal stimulation, while reduced levels of myocardial creatine are a hallmark of the failing heart, leading to the widely held view ...
Rodrigo Ramón - - 2013
The role of oxidative stress in ischaemic heart disease has been thoroughly investigated in humans. Increased levels of ROS (reactive oxygen species) and RNS (reactive nitrogen species) have been demonstrated during ischaemia and post-ischaemic reperfusion in humans. Depending on their concentrations, these reactive species can act either as benevolent molecules ...
Shah Ravish - - 2013
Anemia is a frequent comorbidity of heart failure and is associated with poor outcomes. Anemia in heart failure is considered to develop due to a complex interaction of iron deficiency, kidney disease, and cytokine production, although micronutrient insufficiency and blood loss may contribute. Currently, treatment of anemia of heart failure ...
El-Charabaty Elie - - 2013
Several case reports have been written regarding the relationship between the use of proton pump inhibitors (PPI) and hypomagnesemia. Some of these reported cases have electrocardiogram abnormalities where electrolytes deficiencies were the contributing factor for these events. This study investigates the correlation between different arrhythmias and the use of PPI ...
Matsuzaki Gen - - 2013
Although macrocytic anemia can develop in patients with acute blood loss, such anemia in very old patients is uncommon. In this report, we describe the course of an 89-year-old woman who had a rapid recovery from macrocytic anemia by medication only after acute blood loss due to a gastric ulcer. ...
Zhang Ying - - 2013
Estrogen deficiency is associated with increased incidence of cardiovascular diseases. But merely estrogen supplementary treatment can induce many severe complications such as breast cancer. The present study was designed to elucidate molecular mechanisms underlying increased susceptibility of arrhythmogenesis during myocardial infarction with estrogen deprivation, which provides us a new target ...
Rodrigues Alexandre A Departamento de Clínica Médica, Faculdade de Medicina de Marília, FAMEMA, - - 2013
Patients with thalassemia major present chronic hemolysis and require regular blood transfusions which may cause iron overload cardiomyopathy and chronic heart failure. Hemochromatosis is characterized by excessive iron accumulation in tissues, and heart involvement is the main cause of death in patients with thalassemia. The aim of this study was ...
Kobayashi Toshiyuki T Department of Internal Medicine, Ebina General Hospital, Japan. - - 2013
A woman over 70 years of age presented with anemia and appetite loss. She had no history of blood transfusions, although she had been receiving iron infusions for anemia for seven years. She had an elevated serum ferritin level (7,951 ng/mL) one month before admission. Abdominal computed tomography showed increased ...
Whyte Donna - - 2012
Hemoglobin sickle-hereditary persistence of fetal hemoglobin (S-HPFH) is a condition in which there is compound heterozygosity for the Hb S mutation and the HPFH deletion. These patients have no anemia, little evidence of hemolysis and generally have a benign clinical course compared to other types of sickle cell anemia. We ...
Mahdavi Kamran - - 2012
BACKGROUND: The objectives of this study were estimating the prevalence of vitamin D deficiency in patients with acute coronary syndrome comparing with normal people and evaluating the relationship between vitamin D deficiency and short-term mortality in these patients. METHODS: We considered 106 patients with non-ST elevation myocardial infarction and high-risk ...
Hecker Peter A PA Division of Cardiology and Department of Medicine, University of Maryland, Baltimore, MD, - - 2013
Glucose-6-phosphate dehydrogenase (G6PD) catalyzes the rate-determining step in the pentose phosphate pathway and produces NADPH to fuel glutathione recycling. G6PD deficiency is the most common enzyme deficiency in humans and affects over 400 million people worldwide; however, its impact on cardiovascular disease is poorly understood. The glutathione pathway is paramount ...
Wang Yong - - 2012
OBJECTIVE: To inquire the characteristic proteins in chronic myocardial ischemia by testing two-dimensional electrophoresis (2-DE) map to explore the possible inherent pathological mechanism and the therapeutic intervention of qi deficiency and blood stasis syndrome. METHODS: Ameroid constrictor ring was placed on the first interval of left anterior descending coronary artery ...
Correia Luis C L - - 2012
Vitamin D deficiency is associated with risk for a first cardiovascular event in the general population, possibly because of inflammation, insulin resistance, and neurohumoral activation. However, its relation with outcomes in acute coronary syndromes has not been reported. To test the hypothesis that severe deficiency of vitamin D is independently ...
Hecker Peter A PA Division of Cardiology and Department of Medicine, University of Maryland, Baltimore, MD 21201, - - 2013
Glucose 6-phosphate dehydrogenase (G6PD) is the most common deficient enzyme in the world. In failing hearts, G6PD is upregulated and generates reduced nicotinamide adenine dinucleotide phosphate (NADPH) that is used by the glutathione pathway to remove reactive oxygen species but also as a substrate by reactive oxygen species-generating enzymes. Therefore, ...
Koga Kiyokazu - - 2012
Macrophage migration inhibitory factor (MIF) functions as a pro-inflammatory cytokine when secreted from the cell, but it also exhibits anti-oxidant properties by virtue of its intrinsic oxidoreductase activity. Since increased production of reactive oxygen species (ROS) is implicated in the development of left ventricular hypertrophy, we hypothesized that the redox ...
Metes-Kosik Nicole N VA Boston Healthcare System, West Roxbury, MA 02132, - - 2012
Selenium has complex effects in vivo on multiple homeostatic mechanisms such as redox balance, methylation balance, and epigenesis, via its interaction with the methionine-homocysteine cycle. In this study, we examined the hypothesis that selenium status would modulate both redox and methylation balance and thereby modulate myocardial structure and function. We ...
Shiba Yuji Y Department of Pathology, Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington 98109, - - 2012
Transplantation studies in mice and rats have shown that human embryonic-stem-cell-derived cardiomyocytes (hESC-CMs) can improve the function of infarcted hearts, but two critical issues related to their electrophysiological behaviour in vivo remain unresolved. First, the risk of arrhythmias following hESC-CM transplantation in injured hearts has not been determined. Second, the ...
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