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Bouchentouf M - - 2011
We previously demonstrated that injection of IL-2-activated natural killer (NK) cells contribute to vascular remodeling via a4b7 integrin and killer cell lectin-like receptor (KLRG) 1 and promote cardiac repair following myocardial infarction (MI). The aim of the present study is to test the hypothesis that injection of recombinant human interleukin ...
Freytes Donald O - - 2012
Damaged heart muscle has only a minimal ability for regeneration following myocardial infarction in which cardiomyocytes are lost to ischemia. The most clinically promising approach to regeneration of cardiac muscle currently under investigation is that of injecting cardiogenic repair cells or implanting a preformed tissue-engineered patch. While major advances are ...
Kurotobi Toshiya - - 2011
BACKGROUND: -The addition of a mitral isthmus (MI) block line after pulmonary vein isolation (PVI) could lead to a favorable outcome of catheter ablation (CA) in patients with atrial fibrillation (AF). However, it is sometimes tough to create a complete MI block line, and the cooling effect because of the ...
Leri Annarosa A Departments of Anesthesia and Medicine, and Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, - - 2011
For nearly a century, the human heart has been viewed as a terminally differentiated postmitotic organ in which the number of cardiomyocytes is established at birth, and these cells persist throughout the lifespan of the organ and organism. However, the discovery that cardiac stem cells live in the heart and ...
Herrmann Jeremy L - - 2011
BACKGROUND: Transforming growth factor-α (TGF-α) has been shown to augment mesenchymal stem cell-mediated cardioprotection during acute ischemia and reperfusion in isolated heart models. To determine whether this pretreatment strategy would be effective in vivo, we hypothesized that the intramyocardial injection of mesenchymal stem cells pretreated with TGF-α after coronary artery ...
Couture Pierre - - 2011
OBJECTIVE: To compare real-time (on-line) monitoring of myocardial ischemia with transesophageal echocardiography (TEE) with off-line reviewing during a dobutamine stress test in patients undergoing coronary artery bypass grafting (CABG). DESIGN: Prospective observational study. SETTING: Tertiary care university hospital. PATIENTS: Seventeen patients undergoing CABG. INTERVENTIONS: TEE and electrocardiographic monitoring of myocardial ...
Gibbons Raymond J - - 2011
There are a variety of approaches to assess the efficacy of reperfusion therapy, and myocardial protection, in acute myocardial infarction. This review summarizes the available evidence validating the use of technetium-99m sestamibi single-photon emission computed tomography (SPECT) for this purpose. Multiple lines of evidence have validated its clinical utility. SPECT ...
Otani Niels F - - 2011
Engraftment of viable, electrically functional cells into a myocardial infarct as a method for restoring functionality is currently a topic of active research interest. Cells implanted in this way can form gap junction connectivity with each other, but often do not connect well with the surrounding tissue outside the infarct. ...
Zhou Bin - - 2012
Myocardial infarction (MI) is one of the leading causes of morbidity and mortality world-wide. Whether endogenous repair and regenerative ability could be augmented by drug administration is an important issue for generation of novel therapeutic approach. Recently it was reported that in mice pretreated with thymosin beta 4 (TB4) and ...
Beitnes Jan Otto - - 2011
Despite recent advances in medical therapy, reperfusion strategies, implantable cardioverter-defibrillators and cardiac assist devices, ischemic heart disease is a frequent cause of morbidity and mortality worldwide. Cell therapy has been introduced as a new treatment modality to regenerate lost cardiomyocytes. At present, several cell types seem to improve left ventricular ...
Litton Kimberley A - - 2011
Many people throughout the world are living with heart disease and advanced heart failure. They may be in need of a heart transplant, but because of the limited amount of donor hearts available, other options need to be available. Because of the advancement of technology, there are now other options, ...
Barbone Alessandro - - 2011
Arterial-venous extracorporeal membrane oxygenation (ECMO) is more and more used as first line mechanical support in acute cardiopulmonary failure. Important pitfall of this technique is the inappropriate unloading of left ventricle (LV) in case of myocardial insufficiency, leading to pulmonary stasis and inadequate myocardial recovery. We report our experience of ...
Miyazaki Shinsuke - - 2011
Electrophysiological Change and Mitral Line Block. Background: Achievement of complete conduction block across left mitral isthmus (MI) is a challenging endpoint of linear lesion, and recognizing the precise moment of block is important during ongoing ablation. The objective of this study is to evaluate the changes in P wave morphology and ...
Shi Chun-Zhi - - 2011
This study assessed the potential therapeutic efficacy of endothelial NO syntheses (eNOS)-expressing adipose tissue-derived stem cells (ADSCs) on infarcted hearts. We isolated CD29+, CD44+, CD45- cells from adipose tissue. Multipotent property of ADSCs was characterized by induction to differentiate into myogenic, neurogenic, and endothelic lineages. We hypothesized that combination of ...
Leri Annarosa - - 2011
Human ischemic cardiomyopathy is characterized by de novo cardiomyogenesis, which is limited to the surviving portion of the ventricle, and by organ hypertrophy that develops as a chronic response to ischemic injury. Although myocyte hypertrophy and myocyte regeneration restore the original myocardial mass, the coronary vasculature remains defective and the ...
Mauritz Christina - - 2011
Aims Induced pluripotent stem cell (iPSC)-derived cardiovascular progenitor cells represent a suitable autologous cell source for myocardial regeneration as they have the capability to form myocardial cells and to contribute to revascularization. As a first proof of concept we evaluated the potential of a murine iPSC-derived cardiovascular progenitor population, which ...
Kastrup Jens - - 2011
Coronary artery disease is a growing problem worldwide. Early treatment with stabilizing drugs and revascularization by percutaneous coronary intervention or by-pass surgery has reduced the mortality significantly, but it is still the most common cause of death and a major cause of hospital admissions in industrialized countries. Treatment with stem ...
Forcillo Jessica - - 2011
The IMPACT-CABG study is the first Canadian randomized-controlled phase II clinical trial aiming to assess the effect of intramyocardial (IM) injections of CD133(+)-selected stem cells in patients referred for coronary artery bypass graft (CABG) with a "chronic" myocardial infarction and persistent left ventricular dysfunction. Patients are followed for 2 years ...
Chen Sylvia S M - - 2011
Right ventricular ejection fraction (RV-EF) has traditionally been used to measure and compare RV function serially over time, but may be a relatively insensitive marker of change in RV myocardial contractile function. We developed a cardiovascular magnetic resonance (CMR) tagging-based technique with a view to rapid and reproducible measurement of ...
Suzuki Osamu - - 2011
Sugar chain abnormalities in glycolipids and glycoproteins are associated with various diseases. Here, we report an adult onset cardiac dilatation in a transgenic mouse line with Galβ1,3GalNAc α2,3-sialyltransferase II (ST3Gal-II) transgenes. The transgenic hearts at the end-stage, at around 7 months old, were enlarged, with enlarged cavities and thin, low-tensile ...
Rifai Layla - - 2010
Right-sided forms account for one-fourth of endomyocardial fibrosis cases in central Africa. A 50-year-old female patient with endo-myocardial fibrosis presented with unusual calcifications of the right ventricular endocardium that embedded the tricuspid valve papillary muscles. Bioprosthetic tricuspid valve replacement together with right ventricular endocardectomy was performed with a good clinical ...
Walpot Jeroen - - 2010
The finding of a cardiac myxoma usually implies immediate consequent surgical excision to prevent embolic events. Reports with documented growth rate are therefore very rare, and the actual growth rate remains a controversial issue. We report the growth of a left atrial myxoma in an asymptomatic 65-year-old patient with several ...
Mendoza Dorinna D - - 2010
A cardiac thrombus provides a substrate for thromboembolic events. Delayed enhancement cardiac magnetic resonance imaging detects a thrombus based on avascular tissue properties, and has been shown to provide improved detection of a left ventricular thrombus, compared with anatomic imaging using echocardiography. We present a case of a young man ...
Jann H - - 2010
The aim of the present study was to evaluate frequency, clinical spectrum, and treatment of myocardial metastases in patients with histologically proven neuroendocrine tumors by analysis of our database and literature review. The literature on cardiac metastases in patients with neuroendocrine tumors published from 1973 to the present was reviewed ...
Sianos Georgios - - 2010
The presence of thrombus is associated with adverse clinical outcomes. Our aim was to develop a classification of thrombus burden (TB) in patients with ST-segment elevation myocardial infarction (STEMI). We retrospectively analyzed 900 consecutive patients treated with percutaneous coronary intervention for STEMI. Drug-eluting stents were used in 90.1%. TB was ...
Ramineni Rajesh - - 2010
Peripartum myocardial infarction is uncommon but devastating in young women. Although it is generally associated with arterial dissection, pregnancy-induced hypercoagulable state can also be a major contributor. Association of patent foramen ovale (PFO) adds to this potential risk. A 29-year-old postpartum female presented with worsening chest pressure, shortness of breath ...
Kodali Sobhan - - 2010
The preoperative differentiation of a thrombus from a myxoma is important but not always easy. Clinical and echocardiographic characteristics of myxoma and thrombi are not diverse enough to always reliably distinguish the two. We report the case of a patient who was found to have a left atrial appendage thrombus ...
Kang Sang Soo - - 2010
Acute mesenteric ischemia and infarction is an emergent situation associated with high mortality, commonly due to emboli or thrombosis of the mesenteric arteries. Embolism to the mesenteric arteries is most frequently due to a dislodged thrombus from the left atrium, left ventricle, or cardiac valves. We report a case of ...
Bradshaw Scott H - - 2011
Primary neoplasms of the heart are rare. Benign entities in adult populations include myxoma, fibroma, lipoma, hamartoma of mature myocytes, and vascular hamartoma. The most common pediatric cardiac neoplasm is the rhabdomyoma. We report a 22-year-old female with a primary left ventricle tumor composed of multiple mature mesenchymal tissues, including ...
Hermens J A J M - - 2010
Background. In acute myocardial infarction, thrombus aspiration prior to percutaneous coronary interventions (PCI) is often beneficial, but this approach has never been studied in patients without acute myocardial infarction. The aim of this retrospective study is to shed light on that topic based on our initial experience with manual thrombus ...
Hirota Masanori - - 2010
A case of a large primary cardiac sarcoma on the left ventricular free wall is reported. Although the definitive diagnosis of this tumor was not made preoperatively, total excision was planned for rapid diagnosis and optimal procedure. However, the operation was discontinued due to intraoperative diagnosis of malignancy. As a ...
Debonnaire Philippe - - 2010
We present a case of an obstructive atrial myxoma that was unexpectedly discovered during coronary angiography.
Levy Praschker Beltran G - - 2010
We present the case of a 66-year-old woman who underwent orthotopic heart transplantation 17 years earlier for dilated cardiomyopathy. After 7 years allograft coronary vasculopathy developed requiring coronary artery angioplasty. In year 15 postoperatively she experienced congestive heart failure and she became symptomatic requiring diuretics and digoxin treatment. In year ...
Seder Christopher W - - 2010
Ventricular myxomas are rare, accounting for less than 5% of all benign cardiac tumors. Although histologically benign, myxomas can be a source of significant morbidity and mortality. The case is presented of a left ventricular myxoma involving the posterior papillary muscle that was resected using a minimally invasive transmitral approach. ...
Rafiq Isma - - 2010
Coronary angiography is not an only important component of preoperative evaluation of the patient with underlying coronary artery disease but also diagnostic tool for delineating cardiac myxomas. This also serve as an important surgical anatomical marker. We present two cases which presented with repeated episode of chest pain, were found ...
Rice David C - - 2010
Primary tumors of the heart are uncommon, with roughly 75% benign and 25% malignant. Most of the malignant tumors are sarcomas and historically have had a very poor prognosis. These tumors tend to occur in young patients with a mean age of 40 years. Making a diagnosis of cardiac sarcoma ...
Arı Hasan - - 2011
Primary cardiac tumors of the ventricles are very uncommon. Cardiac lipomas are extremely rare primary benign cardiac tumors. Most reported cardiac lipomas have been diagnosed incidentally at autopsy. Lipomas in both ventricular cavities were not reported before. We report the case of a 51-year-old male referred to our hospital complaining ...
Ben-Dor Itsik - - 2010
Distal embolization during primary percutaneous coronary intervention for acute myocardial infarction is associated with impaired myocardial perfusion and poor outcome. Numerous pharmacological and mechanical strategies have been proposed to prevent and treat distal embolization. A successful combined mechanical and pharmacological approach to a large thrombus-containing lesion in patients with acute ...
Korkmaz Askin Ali - - 2010
Myxomas are common cardiac tumors that are managed by complete excision. The combination of a right atrial and left ventricular myxoma is very rare. We discuss a patient with right atrial and left ventricular myxoma who underwent successful surgical excision of both myxomas. There was no clinical or echocardiographic recurrence ...
Bayram Nihal Akar - - 2010
Infective endocarditis (IE) is an inflammatory disease of the endocardium, with a high morbidity and mortality, particularly when it progresses with predisposing conditions and complications. Embolic events induced by mural cardiac vegetations are a common and life-threatening complication of IE. Herein, we present a first case with left ventricular IE ...
Tamura Harutoshi - - 2010
BACKGROUND: Atrial fibrillation is associated with ischemic stroke because of thrombi that form within the left atrial appendage (LAA). The aim of this study was to develop a new parameter for LAA function that is easily performed using transthoracic echocardiography (TTE). METHODS: TTE and transesophageal echocardiography were performed in 106 ...
Sahin Veysel - - 2010
We describe a case of a massive right atrial myxoma, causing right ventricular inflow obstruction. The tumor was detected by echocardiography and resected along with a section of the tricuspid septal leaflet, followed by primary repair, resulting in relief of her symptoms.
Leonard S - - 2010
Cardiac myxomas are rare. The clinical diagnosis of an atrial myxoma may occur in an asymptomatic patient but may also present with cardiac failure, syncope, arrythmias, or with vascular evidence of tumour embolisation. The delay in diagnosis from presentation is approximately ten months. We present the case of a 53-year-old ...
Erdoes Gabor - - 2010
Cardiac papillary fibroelastoma is a benign tumor that mainly affects cardiac valves. The tumor has the potential to cause angina and myocardial infarction due to embolization of tumor fragments. We describe a rare case of right coronary artery ostial obstruction by a 12 x 19 mm sized papillary fibroelastoma located ...
Naqshband Mumraiz Salik - - 2010
Myxomas are rarely associated with congenital cardiac anomalies. We report a case of a young female presenting with symptoms of atrial myxoma but having co-existing ASD visualized on 64 slice multidetector computed tomography (MDCT) prior to cardiac surgery. Patient had a successful resection of biatrial myxoma and ASD repair. This ...
Darwazah Ahmad K - - 2010
Left ventricular fibroma is a rare benign tumour of the heart. We present the case of a 24-year-old man with left hemiplegia and bilateral popliteal artery occlusion associated with left ventricular mass. The patient underwent successful excision of a pedunculated mass attached to the trabeculae of left ventricular cavity. Histopathologic ...
Yilmaz Atilla - - 2010
Dendritic cells (DC) are crucial for T cell mediated immune responses. Recently, we observed a significant decrease in circulating myeloid DC precursors in patients with acute myocardial infarction (AMI). The aim of the present study was to investigate whether myeloid DC are present in infarcted myocardium. Myocardial specimens of 10 ...
Anwar Ashraf Mohammed - - 2010
The current study was designed to evaluate the feasibility and clinical utility of real-time 3-dimensional echocardiography (RT3DE) for detection of intracardiac thrombi with comparison to 2-dimensional echocardiography (2DE). The study included 45 consecutive patients with intracardiac thrombi detected by routine 2DE (mean age 45 +/- 8.4 years, 75% males). The ...
Dimitrova Kamellia R - - 2010
A case of large cardiac myxoma associated with primary B cell lymphoma is described in a patient presenting with acute obstructive left heart failure. Emergent surgical removal was performed along with mitral valve repair.
Al-Sarraf Nael - - 2010
Atrial myxomas are rare tumors that require surgical excision. However, in the presence of a severely calcified ascending aorta, such excision becomes rather challenging and difficult. Here we report a case of a left atrial myxoma in a 64-year-old woman with an extensively calcified aorta that was successfully excised using ...
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