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Stark Madeline M MM From the *Minneapolis Heart Institute Foundation, Abbott Northwestern Hospital, Minneapolis, MN; †Park Nicollet Heart and Vascular Center, St. Louis Park, MN; and ‡Cedars-Sinai Heart Institute, Los Angeles, - - 2014
Patients with presumed ST-elevation myocardial infarction (STEMI) have no clear culprit artery in approximately 10-15% of cases. We examined the value of cardiac magnetic resonance (CMR) for diagnosis in patients with "no culprit" STEMI. Data from a comprehensive prospective registry of STEMI patients were reviewed from March 2003 to December ...
Komiya Tatsuhiko T Department of Cardiology, Kurashiki Central Hospital, Kurashiki, Japan - - 2014
The optimal strategy for coronary revascularization in patients with renal dysfunction remains undefined. As coronary artery bypass grafting (CABG) may be associated with higher mortality, less invasive percutaneous coronary intervention (PCI) may be preferred. To date, only limited information has been published regarding the effects of severe renal dysfunction on ...
Solanki Pallavi P Division of Cardiovascular Diseases, Rutgers, The State University of New Jersey-New Jersey Medical School, 185 S. Orange Avenue, Newark, NJ, 07103, - - 2014
Concentric hypertrophy is thought to transition to left ventricular (LV) dilatation and systolic failure in the presence of long standing hypertension (HTN). Whether or not this transition routinely occurs in humans is unknown. We consecutively enrolled African American patients hospitalized for acute decompensated volume overload heart failure (HF) in this ...
Wu Xiaofan - - 2014
Background:The impact of obstructive sleep apnea (OSA) treatment with continuous positive airway pressure (CPAP) on percutaneous coronary intervention (PCI) outcomes remains largely unknown. Methods:Between 2002 and 2012 we identified 390 patients with OSA who had undergone a PCI. OSA was diagnosed by in-laboratory sleep studies and defined by an apnea-hypopnea ...
Amano Yasuo Y Department of Radiology, Nippon Medical School, Tokyo, Japan - - 2014
The clinical significance of microvascular obstruction (MO) in hypertrophic cardiomyopathy (HOCM) after percutaneous transluminal septal myocardial ablation (PTSMA) remains unknown. To assess the relationship between the location of MO and the improvement in symptoms and pressure gradient after PTSMA in patients with HOCM. Twenty-three patients with HOCM underwent MRI within ...
Park Duk-Woo DW Division of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea2Duke Clinical Research Institute, Durham, North - - 2014
Little information exists about the anatomical characteristics and clinical relevance of non-infarct-related artery (IRA) disease among patients with ST-segment elevation myocardial infarction (STEMI). To investigate the incidence, extent, and location of obstructive non-IRA disease and compare 30-day mortality according to the presence of non-IRA disease in patients with STEMI. Retrospective ...
Shiono Yasutsugu Y Department of Cardiovascular Medicine, Wakayama Medical - - 2014
Background:A strategy of deferred percutaneous coronary intervention for coronary stenosis with fractional flow reserve (FFR) 0.75-0.80, termed the gray zone, remains a matter of debate. The aim of this study was to assess the safety of deferring revascularization for patients with FFR 0.75-0.80 compared with those with FFR >0.80.Methods and Results:We assessed ...
D'Mello Matthew J J MJ Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, - - 2014
-Telomeres are repetitive, gene-poor regions that cap the ends of DNA and help maintain chromosomal integrity. Their shortening is caused by inflammation and oxidative stress within the cellular environment and ultimately leads to cellular senescence. Shortened leukocyte telomere length (LTL) is hypothesized to be a novel biomarker for age and ...
Azevedo Jader Cunha de JC Universidade Federal Fluminense, Niterói, - - 2014
Background: Recent studies have suggested that B-type Natriuretic Peptide (BNP) is an important predictor of ischemia and death in patients with suspected acute coronary syndrome. Increased levels of BNP are seen after episodes of myocardial ischemia and may be related to future adverse events. Objectives: To determine the prognostic value ...
Muhlestein Joseph B JB Intermountain Medical Center Heart Institute, Murray, Utah2University of Utah School of Medicine, Salt Lake - - 2014
Coronary artery disease (CAD) is a major cause of cardiovascular morbidity and mortality in patients with diabetes mellitus, yet CAD often is asymptomatic prior to myocardial infarction (MI) and coronary death. To assess whether routine screening for CAD by coronary computed tomography angiography (CCTA) in patients with type 1 or ...
Bodén Robert R Unit of Psychiatry, Department of Neuroscience, Uppsala University, Uppsala; Centre for Pharmacoepidemiology at the Department of Medicine, Karolinska Institutet, - - 2014
The aim of this study was to explore the impact of severe mental illness (SMI) on myocardial infarction survival, and determine the influence of risk factor burden, myocardial infarction severity and different treatments. This population-based cohort study, conducted in Sweden during the period 1997-2010, included all patients with a first ...
Ma Yi Y Department of Cardiovascular Medicine, The Tangshan Affiliated Clinical Hospital of Hebei Medical University, Tangshan, - - 2014
Overwhelming clinical and epidemiological studies have identified elevated plasma total homocysteine (Hcy) as new important risk factor for atherosclerotic vascular disease. But the relationship between outcome and hyperhomocysteinemia in patients with acute myocardial infarction (AMI) has been rarely reported. This study aimed to evaluate the association between hyperhomocysteinemia and short-term ...
Pignatelli P - - 2014
There are limited prospective data evaluating the role of urinary F2-IsoP and NOX2 as predictive markers in AF. The aim of this study was to analyse the role of urinary prostaglandin PGF2alpha (8-iso-PGF2α) and NOX2, markers of systemic oxidative stress, in predicting cardiovascular (CV) events and mortality in anticoagulated non-valvular ...
Baysal Erkan E aDepartment of Cardiology, Diyarbakır Gazi Yaşargil Education and Research Hospital bDepartment of Cardiology, Adıyaman University cDepartment of Cardiovascular Surgery, Diyarbakır Gazi Yaşargil Education and Research Hospital, Diyarbakir, - - 2014
Red cell distribution width (RDW) and the neutrophil/lymphocyte ratio (NLR) are predictors of cardiovascular risk that have been shown to correlate with impaired reperfusion and increased morbidity and mortality in patients with an ST-segment elevation myocardial infarction (STEMI). We hypothesized that RDW and the NLR would be associated with failed ...
Izawa Atsushi A Department of Cardiovascular Medicine, Shinshu University School of - - 2014
Background:Statins reduce the incidence of cardiovascular events, but no randomized trial has investigated the best statins for secondary prevention. We compared the efficacy of hydrophilic pravastatin with that of lipophilic atorvastatin in patients with acute myocardial infarction (AMI).Methods and Results:A prospective, multicenter study enrolled 508 patients (410 men; mean age, 66.0±11.6 years) ...
Dopheide Jörn F JF Department of Internal Medicine II, Universitätsmedizin of the Johannes Gutenberg-University Mainz, Langenbeckstr. 1, 55131, Mainz, Germany, - - 2014
Monocytes and dendritic cells (DC) produce tumour necrosis factor (TNF)α during inflammatory processes, but secrete interleukin (IL)-10 simultaneously in order to balance the pro-inflammation. In the present study, we investigated the expression of TNFα and IL-10 by monocytes and DC in patients with a poor cardiovascular prognosis after 10 years. ...
Levine Deborah A DA From the Department of Internal Medicine (D.A.L., K.M.L., M.A.M.R., T.J.I.) and the Department of Neurology and the Stroke Program (D.A.L.), University of Michigan, Ann Arbor; Veterans Affairs Center for Clinical Management Research, Ann Arbor, MI (D.A.L., K.M.L., T.J.I.); Department of Psychiatry and Behavioral Sciences (D.S.D.) and Department of Medicine, University of Washington, Seattle (C.L.H.); and Institute for Social Research, University of Michigan, Ann Arbor (K.M.L., T.J.I.). - - 2014
We assessed the acute and long-term effect of myocardial infarction (MI) and stroke on postevent functional disability and cognition while controlling for survivors' changes in functioning over the years before the event. Among participants in the nationally representative Health and Retirement Study with linked Medicare data (1998-2010), we determined within-person ...
Burkhardt Katrin K Department of Laboratory Medicine and Microbiology, Central Hospital of Augsburg, - - 2014
Hyponatremia is associated with an increased risk of mortality in patients with heart failure and in acute ST-segment elevation myocardial infarction (STEMI). The aim was to assess the impact of hyponatremia on admission on long-term mortality of patients with first ever STEMI or non-STEMI (NSTEMI). This was a longitudinal observation ...
Preim Uta U 1Department of Radiology,University of Leipzig - Heart - - 2014
To test the hypothesis that myocardial scars after repair of tetralogy of Fallot are related to impaired cardiac function and adverse clinical outcome. A total of 53 patients were retrospectively analysed after repair of tetralogy of Fallot. The median patient age was 20 years (range 2-48). Cardiac MRI with a ...
Liu Juan J Department of Internal Medicine, Tianjin Union Medicine Center & Tianjin People's Hospital, Tianjin, - - 2014
Myocardial infarction is a fatal cardiovascular disease and one of the most common death causes all around the world. The aim of the meta-analysis was to quantify the risk of myocardial infarction associated with Helicobacter pylori infection. A literature search was performed to identify studies published before 14 July, 2014, ...
Zeymer U U Klinikum Ludwigshafen, Bremser Str. 79, 67063, Ludwigshafen, Germany, - - 2014
Representative data on the current management of patients with acute coronary syndromes (ACS) are of high interest. The EPICOR registry aimed to prospectively collect such real-life data with particular focus on antithrombotic drug utilization and outcomes. As part of the international prospective EPICOR registry, 29 hospitals in Germany documented 296 ...
Liting P P Department of Cardiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No.197, Ruijin 2nd Road, Shanghai, - - 2014
To explore the clinical value of the combination of apolipoprotein B/apolipoprotein A1 (apoB/A1) and non-high-density lipoprotein cholesterol (HDL-C) in evaluating the severity of coronary heart disease (CHD) and in predicting in-hospital CHD events and the long-term prognosis of CHD patients. According to the results of coronary angiography, 826 patients were ...
Peix Amalia A aInstitute of Cardiology bInstitute of Endocrinology, La Habana, Cuba cNuclear Medicine Section, International Atomic Energy Agency (IAEA), Vienna, - - 2014
The aim of the study was to identify the possible association among myocardial perfusion imaging (MPI) variables, coronary calcium score (CCS), and adverse events at medium term in type 2 asymptomatic diabetes mellitus patients. Patients who participated in a first study that included a stress-rest MPI and a CCS assessment ...
McGrath Emer R ER From the Massachusetts General Hospital, Boston (E.R.M.); National University of Ireland, Galway, Ireland (E.R.M.); University of Toronto, Toronto, Ontario, Canada (M.K.K.); Institute for Clinical Evaluative Sciences (ICES), Toronto, Ontario, Canada (M.K.K., J.F.); McMaster University, Hamilton, Ontario, Canada (J.W.E.); and National University of Ireland, Galway, Ireland (A.O.C., M.C., M.J.O.). - - 2014
For patients with atrial fibrillation and ischemic stroke (IS), current guidelines recommend oral anticoagulation (OAC) alone for secondary prevention of IS. In a large prospective cohort of patients with acute IS and atrial fibrillation, we determine the association between antithrombotic regimen on discharge and risk of major vascular events. Prospective ...
Stefánsson Bergur V BV AstraZeneca Inc., Mölndal, Sweden; - - 2014
Patients undergoing hemodialysis have an elevated risk of cardiovascular disease-related morbidity and mortality compared with the general population. Intradialytic hypotension (IDH) is estimated to occur during 20%-30% of hemodialysis sessions. To date, no large studies have examined whether IDH is associated with cardiovascular outcomes. This study determined the prevalence of ...
Panduranga Prashanth P Department of Cardiology, Royal Hospital, Muscat, - - 2014
We compared baseline characteristics, clinical presentation, and in-hospital outcomes between Middle Eastern Arabs and Indian subcontinent patients presenting with acute coronary syndrome (ACS). Of the 7930 patients enrolled in Gulf Registry of Acute Coronary Events II (RACE II), 23% (n = 1669) were from the Indian subcontinent. The Indian subcontinent ...
Bekler Adem A Department of Cardiology, Canakkale Onsekiz Mart University, School of Medicine, Canakkale/TURKEY. - - 2014
Fragmented QRS (fQRS) complexes on 12-lead electrocardiography (ECG) have been reported to be pre-dictors of cardiac events and all-cause mortality in coronary artery disease (CAD). We aimed to investigate the relationship between fQRS complexes and SYNTAX and Gensini scores in patients with acute coronary syndrome (ACS). : METHODS: A total ...
Ritzenthaler Thomas T Service d'urgences Neuro-vasculaires, Hôpital Neurologique, Hospices Civils de Lyon, 59 Bld Pinel, 69677, Bron Cedex, France, - - 2014
Monitoring recanalization and reperfusion during acute ischemic stroke is a challenge for therapeutic assessment. Near-infrared spectroscopy (NIRS) allows continuous monitoring of the brain regional saturation of oxygen (rSO2). We sought to evaluated rSO2 variation during mechanical thrombectomy during acute ischemic stroke. Three patients admitted for middle cerebral artery occlusion were ...
Iqbal M Bilal MB From the Department of Cardiology, Royal Brompton and Harefield NHS Foundation Trust, Harefield Hospital, Middlesex, United Kingdom (M.B.I., C.I., T.K., R.S., R.L., M.M., P.C., M.D.); Department of Cardiology, UCL Hospitals NHS Foundation Trust, Heart Hospital, London, United Kingdom (T.C., P. Meier); Department of Cardiology, King's College Hospital NHS Foundation Trust, London, United Kingdom (S.K., P. MacCarthy); Department of Cardiology, Barts Health NHS Trust, The London Chest Hospital, London, United Kingdom (C.K., A.M., D.B., K.R.); Department of Cardiology, St. George's Healthcare NHS Foundation Trust, St. George's Hospital, London, United Kingdom (S.F., P.L.); Department of Cardiology, Imperial College Healthcare NHS Foundation Trust, Hammersmith Hospital, London, United Kingdom (I.S.M.); Department of Cardiology, Royal Free London NHS Foundation Trust, London, United Kingdom (R.D.R.); Department of Cardiology, BHF Centre of Excellence, King's College London, St. Thomas Hospital, London, United Kingdom (S.R.); and Department of Cardiology, London Ambulance Service, London, United Kingdom (M.W.). - - 2014
It is estimated that up to two thirds of patients presenting with ST-segment-elevation myocardial infarction have multivessel disease. The optimal strategy for treating nonculprit disease is currently under debate. This study provides a real-world analysis comparing a strategy of culprit-vessel intervention (CVI) versus multivessel intervention at the time of primary ...
Gagne Brosseau Marie-Sarah MS 1Department of Neurology, Faculty of Medicine,Sherbrooke University,Sherbrooke,Greenfield - - 2014
Background: Atrial fibrillation (AF) is a cause of ischemic stroke and is associated with recurrence and with acute multi-vessel territory non lacunar stroke. Many cryptogenic strokes could be secondary to undiagnosed paroxystic AF. As left atrium (LA) dilatation is a risk factor of AF, we sought to determine if moderate ...
Raff Ulrike U aDepartment of Nephrology and Hypertension, University Hospital of the University Erlangen-Nürnberg, Erlangen, Germany bHypertension Unit, Hospital 12 de Octubre cDepartment of Preventive Medicine and Public Health, Universidad Autónoma, Madrid, Spain dDepartment of Nephrology and Hypertension, Medical School Hannover, Hannover, - - 2014
To assess the ability of olmesartan (OLM) to prevent or delay left ventricular remodeling and hypertrophy in patients with type 2 diabetes. This prespecified ECG substudy of Randomised OlmesArtan and Diabetes MicroAlbuminuria Prevention (ROADMAP), which compared OLM with placebo, assessed the signs of left ventricular remodeling in patients with a ...
Charytan David D Renal Division, Brigham and Women's Hospital, Boston, Massachusetts, - - 2014
Left ventricular hypertrophy (LVH) is common in end-stage renal disease (ESRD) and has been advocated as a therapeutic target. We review the considerations for targeting LVH as a modifiable risk factor in ESRD. Pathologic myocardial changes underlying LVH provide an ideal substrate for the spread of arrhythmia and may be ...
Chen Shaomin S Department of Cardiology, Key Laboratory of Cardiovascular Molecular Biology and Regulatory peptides, Ministry of Health, Peking University Third Hospital , Beijing , - - 2014
Abstract Objective: To investigate the dynamic changes in serum tryptase levels and their association with clinical data in patients with acute ST-elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI). Serum tryptase levels were measured in 99 STEMI patients and 25 control subjects. Tryptase levels were significantly increased ...
Sattur Sudhakar S Division of Cardiology, Department of Medicine, New York Methodist Hospital, Brooklyn, New York, USA. - - 2014
To correlate early and late mortality with markers of reperfusion in ST-elevation myocardial infarction (STEMI). Early reperfusion improves STEMI outcomes. Reperfusion can be assessed using angiographic (Thrombolysis in Myocardial Infarction [TIMI] flow grade or myocardial blush grade [MBG]) or electrocardiographic markers (ST-segment recovery (STR). We searched electronic databases for all ...
Börekçi A A Department of Cardiology, Kafkas University School of Medicine, Kars, - - 2014
Compared to patients without a collateral supply, long-term cardiac mortality is reduced in patients with well-developed coronary collateral circulation (CCC). Cardiovascular risk markers, such as N-terminal pro-brain natriuretic peptide (NT-proBNP), high-sensitive C-reactive protein (hs-CRP) and high-sensitive cardiac troponin T (hs-cTnT) are independent predictors for cardiovascular mortality. The main goal of ...
Yerebakan Halit - - 2014
ObjectiveDel Nido (DN) cardioplegia solution provides a depolarized hyperkalemic arrest lasting up to 60 minutes, and the addition of lidocaine may limit intracellular calcium influx. Single-dose DN cardioplegia solution may offer an alternative myocardial protection strategy to multi-dose cold whole blood (WB) cardioplegia following acute myocardial infarction (AMI).MethodsWe retrospectively reviewed 88 ...
Hwang Hyeon Seok HS Division of Nephrology, Department of Internal Medicine, The Catholic University of Korea, Seoul, - - 2014
Background/Aims: Atrial fibrillation (AF) often coexists with acute myocardial infarction (AMI), and chronic kidney disease (CKD) is a major risk for AMI. However, the combined impact of CKD and AF on the mortality and morbidity in AMI population has not been determined. Methods: Between January 2004 and December 2009, a ...
Pennell Dudley J DJ Royal Brompton Hospital, London, - - 2014
Long-term controlled studies are needed to inform on the clinical benefit of chelation therapy for myocardial iron removal in transfusion-dependent beta thalassemia patients. In a 1-year non-randomized extension to the CORDELIA study, data collected from patients with myocardial siderosis provided additional information on deferasirox or deferoxamine (DFO) efficacy and safety. ...
Hanson S R SR Department of Neurology, Haukeland University Hospital, Bergen, - - 2014
To investigate long-term outcome in patients with spontaneous spinal cord infarctions and secondly to compare outcome with that of patients with cerebral infarction. The study includes 30 patients with spinal cord infarction discharged between 1995 and 2010. Surviving patients were contacted by telephone and sent a questionnaire. Data on employment, ...
Morici Nuccia N Azienda Ospedaliera Ospedale Niguarda Cà Granda, Italy - - 2014
To determine the association between baseline creatinine clearance (CrCl), coronary revascularization during index admission, and 1-year mortality in elderly patients with an acute coronary syndrome (ACS). We estimated CrCl using the Cockcroft-Gault (CG) formula in 313 patients aged ≥75 years enrolled in a prospective study of treatment strategies in non ...
Jeżewski Tomasz T Medical Diagnostics Księży Młyn, Lodz, - - 2014
Early initiation of reperfusion therapy including primary percutaneous coronary revascularization (PPCI) has been recognized as a crucial factor determining clinical outcomes in the acute phase of myocardial infarction. In unstable patients with type 2 diabetes mellitus (T2D) the clear benefit from PPCI was proven. We aim to evaluate the prognostic ...
Ng Leong L LL Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, United Kingdom; National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, United Kingdom. Electronic address: - - 2014
Pro-substance P (ProSP) is a stable surrogate marker for labile substance P, which has pro-inflammatory effects, increases platelet aggregation and clot strength, and reduces fibrinolysis. This study assessed whether ProSP was associated with poor prognosis after acute myocardial infarction (AMI) to identify novel pathophysiological mechanisms. ProSP was measured in 1,148 AMI ...
Li Jin J Department of Cardiology, University Hospital of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, - - 2014
Left ventricular noncompaction (LVNC) is a cardiomyopathy with hypertrabeculation of the LV, often complicated by heart failure, arrhythmia and thromboembolic events. The features of LVNC are still incompletely characterized due to its late recognition as clinically relevant condition. The aims of this study were to describe echocardiographic and electrophysiologic characteristics ...
Cao Xue-Sen XS Department of Nephrology, Shanghai Institute of Kidney and Dialysis, Shanghai Key Laboratory of Kidney and Blood Purification, Zhongshan - - 2014
Indoxyl sulfate, a protein-bound uremic toxin, may be associated with cardiovascular events and mortality in patients with CKD. This study aimed to investigate the relationship between indoxyl sulfate and heart failure in patients on hemodialysis. Patients on hemodialysis for >6 months were enrolled within 6 months. Patients with congestive heart ...
Baron Tomasz T Department of Medical Sciences, Uppsala Clinical Research Center, Uppsala University, Uppsala, - - 2014
We aimed to assess differences in incidence, clinical features, current treatment strategies and outcome in patients with type 2 vs. type 1 acute myocardial infarction (AMI). All 20 138 hospitalisations in Sweden with a diagnosis of AMI registered during 2011 in the Swedish Web-system for Enhancement and Development of Evidence-based care ...
Choudry Fa F London Chest Hospital, Barts Health NHS Trust, UK National Institute for Health Research (NIHR) Cardiovascular Biomedical Research Unit, Barts Health NHS Trust, - - 2014
Current recommendations are for primary percutaneous coronary intervention (pPCI) in ST-elevation myocardial infarction (STEMI) complicated by out of hospital cardiac arrest (OHCA). However, information about longer-term outcomes is sparse, particularly among high-risk patients who do not regain consciousness promptly after resuscitation. Of 1836 consecutive patients admitted with STEMI for pPCI ...
Leung Kelvin C W KC Departments of Medicine - - 2014
AKI after coronary angiography is associated with poor long-term outcomes. The relationship between contrast-associated AKI and subsequent use of prognosis-modifying cardiovascular medications is unknown. A cohort study of 5911 participants 66 years of age or older with acute coronary syndrome who received a coronary angiogram in Alberta, Canada was performed ...
Søholm Helle H Department of Cardiology 2142, Copenhagen University Hospital Rigshospitalet, Denmark - - 2014
Changes in left ventricular (LV) function using echocardiography and cardiac magnetic resonance (CMR) imaging were assessed in a contemporary ST-segment elevation myocardial infarction (STEMI) population to assess whether repeated imaging is necessary. In a prospective study patients with first STEMI were treated with primary percutaneous coronary intervention (PCI) and examined ...
Cavender Matthew A MA TIMI Study Group, Heart & Vascular Center, Brigham and Women's Hospital and Harvard Medical School, - - 2014
Rivaroxaban reduces cardiovascular death, myocardial infarction (MI), or stroke in patients following acute coronary syndrome (ACS). We aimed to characterize the specific effects of rivaroxaban on the size and type of MI. The Anti-Xa Therapy to Lower Cardiovascular Events in Addition to Standard Therapy in Subjects with Acute Coronary Syndrome-Thrombolysis ...
Xie Wenchao W Department of Cardiology, Yulin First People's Hospital, Sixth Affiliated Hospital of Guangxi Medical University, No. 497 Education Road, Yulin, Guangxi, 537000, - - 2014
The benefical effect of rosuvastatin against percutaneous coronary intervention (PCI) related procedural myocardial injury has been determined mostly in patients with acute coronary syndromes (ACS). However, the detailed therapeutic mechanism has not been well studied. Patients with ACS receiving PCI (n=159) were randomized to control group (placebo treatment) or to ...
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