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Jones W Schuyler WS Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina; Division of Cardiology, Duke University Medical Center, Durham, North - - 2014
Primary percutaneous coronary intervention (PCI) is the most common method of reperfusion in patients with ST-segment elevation myocardial infarction (STEMI) in the United States. The intersection between processes of care and performance measures such as door-to-balloon (D2B) times and clinical trials evaluating novel therapies for STEMI has not been fully ...
Vora Amit N AN Duke Clinical Research Institute, Duke University Medical Center, Durham, North - - 2014
Guidelines for patients with ST-segment elevation myocardial infarction (STEMI) recommend timely reperfusion with primary percutaneous coronary intervention (pPCI) or fibrinolysis. Among patients with STEMI who require interhospital transfer, it is unclear how reperfusion strategy selection and outcomes vary with interhospital drive times. To assess the association of estimated interhospital drive ...
Aslanabadi Naser N Cardiovascular Research Center, Shahid Madani Heart Center, Tabriz University of Medical Sciences, Tabriz, - - 2014
Periprocedural myocardial injury (PMI) following percutaneous coronary intervention (PCI) has received great attention due to its significant association with mortality and morbidity. Accordingly, cardioprotection during PCI is one of the important therapeutic concerns. Regarding the potential cardiovascular benefits of pentoxifylline this study was performed to evaluate whether the pretreatment pentoxifylline ...
Loforte Antonio A Department of Cardiovascular Surgery and Transplantation, S. Orsola-Malpighi Hospital, Bologna University, Bologna, - - 2014
RotaFlow and Levitronix CentriMag veno-arterial extracorporeal membrane oxygenation (ECMO) support systems have been investigated as treatment for refractory cardiogenic shock (CS). Between 2004 and 2012, 119 consecutive adult patients were supported on RotaFlow (n = 104) or CentriMag (n = 15) ECMO at our institution (79 men; age 57.3 ± 12.5 years, range:19-78 years). Indications for ...
Yagi Shusuke - - 2014
Recent studies have shown that intake of n-3 polyunsaturated fatty acids (PUFAs) is associated with reduced risk of cognitive impairment and coronary artery disease (CAD); however, it is currently unknown whether reduced serum n-3 PUFA is associated with cognitive impairment in patients with CAD. We retrospectively evaluated cognitive function with ...
Menting Myrthe E ME Department of Cardiology, Erasmus MC, Room Ba-583a, PO Box 2040, CA 3000 Rotterdam, The - - 2014
It is unknown whether right-ventricular (RV) volume overload caused by an atrial septal defect (ASD) still has its effect on RV deformation long after repair. We evaluated RV and left-ventricular (LV) deformation beyond 30 years after surgical ASD repair in childhood, and studied relationships with conventional diagnostic parameters. In this ...
Bulte Carolien S E CS Department of Anesthesiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, the - - 2014
Cardiac complication following noncardiac surgery is the leading cause of death in the perioperative period. Disturbances in myocardial perfusion are at the basis of these complications. The purpose of this review was to summarize the most recent findings on factors affecting myocardial perfusion in the perioperative period and possibilities for ...
Luz André A Serviço de Cardiologia, Centro Hospitalar do Porto, E.P.E., Porto, Portugal. Electronic address: - - 2014
The benefit of manual thrombus aspiration (TA) in the reperfusion of patients with ST-elevation myocardial infarction (STEMI) has been hotly debated. In most series, failure of TA has been largely unreported. Our objectives were to assess the rate, predictors, and impact on cumulative mortality of failed TA during primary percutaneous ...
Aramburu-Bodas Oscar O aDepartment of Internal Medicine, Hospital Virgen Macarena bDepartment of Internal Medicine, Hospital Virgen de la Merced, Osuna cDepartment of Critical Care and Emergency, Hospital Virgen Macarena, Seville dDepartment of Internal Medicine, Hospital Infanta Margarita, Cabra, Córdoba eDepartment of Clinical Chemistry and Laboratory Medicine, Hospital Virgen Macarena fDepartment of Internal Medicine, Hospital NISA Sevilla Aljarafe, Seville gDepartment of Internal Medicine, Hospital of Bellvitge, L'Hospitalet de Llobregat, Barcelona hDepartment of Internal Medicine, IMIBIC/Hospital Reina Sofía, University of Córdoba, Córdoba iDepartment of Internal Medicine, Hospital Ramón y Cajal, University of Alcalá, Madrid, - - 2014
The aim of this study was to evaluate whether osteoprotegerin - an emerging inflammatory biomarker in cardiovascular diseases - predicts outcomes in patients with acute heart failure and preserved ejection fraction. We measured urea, creatinine, hemoglobin, high-sensitivity C-reactive protein, N-terminal pro-B-type natriuretic peptide and osteoprotegerin on admission in 177 patients ...
Stark Madeline M MM From the *Minneapolis Heart Institute Foundation, Abbott Northwestern Hospital, Minneapolis, MN; †Park Nicollet Heart and Vascular Center, St. Louis Park, MN; and ‡Cedars-Sinai Heart Institute, Los Angeles, - - 2014
Patients with presumed ST-elevation myocardial infarction (STEMI) have no clear culprit artery in approximately 10-15% of cases. We examined the value of cardiac magnetic resonance (CMR) for diagnosis in patients with "no culprit" STEMI. Data from a comprehensive prospective registry of STEMI patients were reviewed from March 2003 to December ...
Qian Geng G Department of Cardiology, Chinese PLA General Hospital, Beijing 100853, China; Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China; Department of Cardiology, Lujiang People's Hospital, Anhui 231500, - - 2014
Cardiac rupture (CR) is a potentially fatal mechanical complication of ST-elevation myocardial infarction (STEMI). We aimed to determine the incidence and risk factors of CR in Chinese STEMI patients. A total of 9798 consecutive STEMI patients from four centers in China were retrospectively analyzed, among which 178 patients had CR. ...
Ostenfeld Sarah S Department of Thoracic Anaesthesia, The Heart Centre, Rigshospitalet - Copenhagen University Hospital. Denmark. Electronic address: - - 2014
To compare outcome in patients with acute myocardial infarction (MI) and cardiogenic shock (CS) presenting with and without out-of-hospital cardiac arrest (OHCA). Despite general improvement in outcome after acute MI, CS remains a leading cause of death in acute MI patients with a high 30-day mortality rate. OHCA on top ...
Ahmadi Ali - - 2014
Myocardial infarction (MI) care and treatment contribute greatly to the patients' fatality and mortality. Assessing and monitoring mortalities and the effective factors are necessary in MI care and treatment programs. No comprehensive and population-based study has been yet conducted in Iran to determine the epidemiologic pattern of MI and particularly ...
Ozdemir Semra S Department of Nuclear Medicine, Faculty of Medicine, Canakkale Onsekiz Mart University, 17100, Canakkale, Turkey, - - 2014
Hypertension is one of the most important risk factors for cardiovascular disease. However, hypertension may also result in left ventricular dyssynchrony (LVD) which is characterized by delayed activation of certain ventricular segments leading to uncoordinated contraction. The aim of this study was to evaluate the LVD measured by phase analysis ...
Park Jin Sup JS Department of Cardiology, Pusan National University Hospital, Busan, South - - 2014
We evaluated the impact of normal vs. high presenting blood pressure (BP) on clinical outcomes and cardiac function in patients with ST-elevation myocardial infarction (MI). In 11,292 patients, in-hospital mortality and major adverse clinical events (MACE; all-cause death, nonfatal MI, or any revascularization) during follow-up were compared between patients with ...
Hai Jo Jo JJ Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, Department of Internal Medicine, Mayo Clinic, Rochester, - - 2014
Catheter ablation of ventricular arrhythmia (VA) at the fibrous aortic mitral continuity (AMC) has been described, yet the nature of the arrhythmogenic substrate remains unknown. Procedural records of 528 consecutive patients undergoing ablation of VA at Mayo Clinic, Rochester, MN, were reviewed. The electrocardiographic and electrophysiologic characteristics of patients with ...
Kocas Cuneyt C Department of Cardiology, Istanbul University Institute of Cardiology, Haseki, Aksaray, 34350, Istanbul, Turkey, - - 2014
Hyperglycemia on admission is associated with increased mortality rates in patients with ST-elevation myocardial infarction (STEMI) who are treated with either fibrinolytic therapy (FT) or primary percutaneous coronary intervention (PCI). However, data regarding the relationship between hyperglycemia and the success of FT are lacking. The aim of this study was ...
Panoulas Vasileios F VF Imperial College Healthcare NHS Trust, Hammersmith Hospital, Du Cane Road, London W12 0HS, UK Imperial College London, National Heart and Lung Institute, Sir Alexander Fleming Building, South Kensington Campus, London SW7 2AZ, UK - - 2014
To identify subclinical left ventricular (LV) myocardial dysfunction using speckle tracking echocardiography (STE) in patients with chronic kidney disease (CKD), preserved LV ejection fraction (LVEF), and no cardiovascular history or symptoms. Cross-sectional comparisons of conventional and STE parameters were performed between controls and patients with different stages of CKD. CKD ...
Matsue Yuya Y Department of Cardiology, Kameda Medical Center, Chiba, Japan;; Department of Life Science and Bioethics, Tokyo Medical and Dental University. Electronic address: - - 2014
Although prognosis of vasospastic angina is generally considered excellent, vasospasm has been shown to be a cause of type 2 myocardial infarction. This study was performed to investigate the clinical characteristics and prognosis of patients with vasospastic angina complicated with type 2 myocardial infarction . We performed a retrospective analysis ...
Magne Julien J CHU Limoges, Hôpital Dupuytren, Service Cardiologie, Limoges, F-87042, France; INSERM 1094, Faculté de médecine de Limoges, 2, rue Marcland, 87000 Limoges, France; CHU Limoges, Hôpital Dupuytren, Service de Chirurgie Thoracique et Cardiovasculaire, Limoges F-87042, - - 2014
Global left ventricular (LV) afterload as assessed by valvulo-arterial impedance (Zva), may be an independent predictor of mortality in patients with severe aortic stenosis (AS) and preserved LV ejection fraction (LVEF). However, its quantification using echocardiography may be subject to error measurement. We aimed to determine the prevalence and impact ...
Hagiwara Magnus - - 2014
BackgroundFor each hour of delay from fist medical contact until reperfusion in ST-elevation myocardial infarction (STEMI) there is a 10% increase in risk of death and heart failure. The aim of this review is to describe the impact of the direct admission of patients with STEMI to a Catheterisation laboratory ...
Spyridopoulos Ioakim I Freeman Hospital, Newcastle Upon Tyne, UK Institute of Genetic Medicine, Newcastle University, - - 2014
Early identification of higher risk patients presenting with ST-elevation myocardial infarction (STEMI) and undergoing primary percutaneous coronary intervention (PPCI) will allow a more aggressive strategy and approach. The aim of this study was to evaluate the shock index (ratio of heart rate/systolic blood pressure on admission) as a predictor of ...
Ueland Thor T Research Institute for Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, - - 2014
Objectives: Increased circulating endostatin levels have been demonstrated in progressive cardiovascular (CV) and renal disorders. We investigated the predictive value of endostatin in patients with chronic heart failure (HF) and the association between endostatin and renal function. Methods: The interaction between serum endostatin, estimated glomerular filtration rate (eGFR) and predefined ...
Komiya Tatsuhiko T Department of Cardiology, Kurashiki Central Hospital, Kurashiki, Japan - - 2014
The optimal strategy for coronary revascularization in patients with renal dysfunction remains undefined. As coronary artery bypass grafting (CABG) may be associated with higher mortality, less invasive percutaneous coronary intervention (PCI) may be preferred. To date, only limited information has been published regarding the effects of severe renal dysfunction on ...
Solanki Pallavi P Division of Cardiovascular Diseases, Rutgers, The State University of New Jersey-New Jersey Medical School, 185 S. Orange Avenue, Newark, NJ, 07103, - - 2014
Concentric hypertrophy is thought to transition to left ventricular (LV) dilatation and systolic failure in the presence of long standing hypertension (HTN). Whether or not this transition routinely occurs in humans is unknown. We consecutively enrolled African American patients hospitalized for acute decompensated volume overload heart failure (HF) in this ...
Wu Xiaofan - - 2014
Background:The impact of obstructive sleep apnea (OSA) treatment with continuous positive airway pressure (CPAP) on percutaneous coronary intervention (PCI) outcomes remains largely unknown. Methods:Between 2002 and 2012 we identified 390 patients with OSA who had undergone a PCI. OSA was diagnosed by in-laboratory sleep studies and defined by an apnea-hypopnea ...
Amano Yasuo Y Department of Radiology, Nippon Medical School, Tokyo, Japan - - 2014
The clinical significance of microvascular obstruction (MO) in hypertrophic cardiomyopathy (HOCM) after percutaneous transluminal septal myocardial ablation (PTSMA) remains unknown. To assess the relationship between the location of MO and the improvement in symptoms and pressure gradient after PTSMA in patients with HOCM. Twenty-three patients with HOCM underwent MRI within ...
Shortt Colleen C Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada; Department of Medicine, McMaster University, Hamilton, - - 2014
The application of "undetectable" high-sensitivity cardiac troponin (hs-cTn) concentrations to "rule-out" myocardial infarction is appealing, but there are analytical concerns and a lack of consensus on what concentration should be used to define the lower reportable limit; i.e., limit of detection (LoD) or limit of blank. An alternative approach is ...
Park Duk-Woo DW Division of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea2Duke Clinical Research Institute, Durham, North - - 2014
Little information exists about the anatomical characteristics and clinical relevance of non-infarct-related artery (IRA) disease among patients with ST-segment elevation myocardial infarction (STEMI). To investigate the incidence, extent, and location of obstructive non-IRA disease and compare 30-day mortality according to the presence of non-IRA disease in patients with STEMI. Retrospective ...
Shiono Yasutsugu Y Department of Cardiovascular Medicine, Wakayama Medical - - 2014
Background:A strategy of deferred percutaneous coronary intervention for coronary stenosis with fractional flow reserve (FFR) 0.75-0.80, termed the gray zone, remains a matter of debate. The aim of this study was to assess the safety of deferring revascularization for patients with FFR 0.75-0.80 compared with those with FFR >0.80.Methods and Results:We assessed ...
D'Mello Matthew J J MJ Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, - - 2014
-Telomeres are repetitive, gene-poor regions that cap the ends of DNA and help maintain chromosomal integrity. Their shortening is caused by inflammation and oxidative stress within the cellular environment and ultimately leads to cellular senescence. Shortened leukocyte telomere length (LTL) is hypothesized to be a novel biomarker for age and ...
Azevedo Jader Cunha de JC Universidade Federal Fluminense, Niterói, - - 2014
Background: Recent studies have suggested that B-type Natriuretic Peptide (BNP) is an important predictor of ischemia and death in patients with suspected acute coronary syndrome. Increased levels of BNP are seen after episodes of myocardial ischemia and may be related to future adverse events. Objectives: To determine the prognostic value ...
Muhlestein Joseph B JB Intermountain Medical Center Heart Institute, Murray, Utah2University of Utah School of Medicine, Salt Lake - - 2014
Coronary artery disease (CAD) is a major cause of cardiovascular morbidity and mortality in patients with diabetes mellitus, yet CAD often is asymptomatic prior to myocardial infarction (MI) and coronary death. To assess whether routine screening for CAD by coronary computed tomography angiography (CCTA) in patients with type 1 or ...
Bodén Robert R Unit of Psychiatry, Department of Neuroscience, Uppsala University, Uppsala; Centre for Pharmacoepidemiology at the Department of Medicine, Karolinska Institutet, - - 2014
The aim of this study was to explore the impact of severe mental illness (SMI) on myocardial infarction survival, and determine the influence of risk factor burden, myocardial infarction severity and different treatments. This population-based cohort study, conducted in Sweden during the period 1997-2010, included all patients with a first ...
Ma Yi Y Department of Cardiovascular Medicine, The Tangshan Affiliated Clinical Hospital of Hebei Medical University, Tangshan, - - 2014
Overwhelming clinical and epidemiological studies have identified elevated plasma total homocysteine (Hcy) as new important risk factor for atherosclerotic vascular disease. But the relationship between outcome and hyperhomocysteinemia in patients with acute myocardial infarction (AMI) has been rarely reported. This study aimed to evaluate the association between hyperhomocysteinemia and short-term ...
Gold Michael R MR Medical University of South Carolina, Charleston, SC. Electronic address: - - 2014
Cardiac resynchronization therapy (CRT) decreases mortality, improves functional status and induces reverse left ventricular (LV) remodeling in selected populations with heart failure (HF). The magnitude of reverse remodeling predicts survival with many HF medical therapies. However, there are little data assessing the impact of remodeling on long term survival with ...
Pignatelli P - - 2014
There are limited prospective data evaluating the role of urinary F2-IsoP and NOX2 as predictive markers in AF. The aim of this study was to analyse the role of urinary prostaglandin PGF2alpha (8-iso-PGF2α) and NOX2, markers of systemic oxidative stress, in predicting cardiovascular (CV) events and mortality in anticoagulated non-valvular ...
Baysal Erkan E aDepartment of Cardiology, Diyarbakır Gazi Yaşargil Education and Research Hospital bDepartment of Cardiology, Adıyaman University cDepartment of Cardiovascular Surgery, Diyarbakır Gazi Yaşargil Education and Research Hospital, Diyarbakir, - - 2014
Red cell distribution width (RDW) and the neutrophil/lymphocyte ratio (NLR) are predictors of cardiovascular risk that have been shown to correlate with impaired reperfusion and increased morbidity and mortality in patients with an ST-segment elevation myocardial infarction (STEMI). We hypothesized that RDW and the NLR would be associated with failed ...
Shacham Yacov Y Department of Cardiology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. Electronic address: - - 2014
Acute kidney injury (AKI) is a common complication among patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI), and it is associated with poor long-term clinical outcomes. No studies have yet evaluated the association between cardiac function and the risk of AKI in this patient population. ...
Nascimento Bruno R BR Division of Cardiology and Cardiovascular Surgery, Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; Serviço de Hemodinâmica, Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Electronic address: - - 2014
Fractional flow reserve (FFR) has been proposed as the gold standard to assess functional severity of coronary artery stenosis and to stratify which lesions should be subjected to intervention (percutaneous coronary intervention [PCI]). A systematic review was performed in MEDLINE and EMBASE including studies indexed until November 2013 that used ...
Izawa Atsushi A Department of Cardiovascular Medicine, Shinshu University School of - - 2014
Background:Statins reduce the incidence of cardiovascular events, but no randomized trial has investigated the best statins for secondary prevention. We compared the efficacy of hydrophilic pravastatin with that of lipophilic atorvastatin in patients with acute myocardial infarction (AMI).Methods and Results:A prospective, multicenter study enrolled 508 patients (410 men; mean age, 66.0±11.6 years) ...
Dopheide Jörn F JF Department of Internal Medicine II, Universitätsmedizin of the Johannes Gutenberg-University Mainz, Langenbeckstr. 1, 55131, Mainz, Germany, - - 2014
Monocytes and dendritic cells (DC) produce tumour necrosis factor (TNF)α during inflammatory processes, but secrete interleukin (IL)-10 simultaneously in order to balance the pro-inflammation. In the present study, we investigated the expression of TNFα and IL-10 by monocytes and DC in patients with a poor cardiovascular prognosis after 10 years. ...
Levine Deborah A DA From the Department of Internal Medicine (D.A.L., K.M.L., M.A.M.R., T.J.I.) and the Department of Neurology and the Stroke Program (D.A.L.), University of Michigan, Ann Arbor; Veterans Affairs Center for Clinical Management Research, Ann Arbor, MI (D.A.L., K.M.L., T.J.I.); Department of Psychiatry and Behavioral Sciences (D.S.D.) and Department of Medicine, University of Washington, Seattle (C.L.H.); and Institute for Social Research, University of Michigan, Ann Arbor (K.M.L., T.J.I.). - - 2014
We assessed the acute and long-term effect of myocardial infarction (MI) and stroke on postevent functional disability and cognition while controlling for survivors' changes in functioning over the years before the event. Among participants in the nationally representative Health and Retirement Study with linked Medicare data (1998-2010), we determined within-person ...
Burkhardt Katrin K Department of Laboratory Medicine and Microbiology, Central Hospital of Augsburg, - - 2014
Hyponatremia is associated with an increased risk of mortality in patients with heart failure and in acute ST-segment elevation myocardial infarction (STEMI). The aim was to assess the impact of hyponatremia on admission on long-term mortality of patients with first ever STEMI or non-STEMI (NSTEMI). This was a longitudinal observation ...
Guzzo-Merello Gonzalo G Heart Failure and Cardiomyopathy Unit, Heart Failure and Heart Transplant Section, Department of Cardiology, Hospital Universitario Puerta de Hierro, Madrid, - - 2014
This study sought to determine the natural history of contemporary alcoholic cardiomyopathy (ACM), to compare it with that of idiopathic dilated cardiomyopathy (IDCM), and to identify risk factors for poor outcome. ACM is a common cause of dilated cardiomyopathy (DCM), but little is known about its natural history or the effect ...
Preim Uta U 1Department of Radiology,University of Leipzig - Heart - - 2014
To test the hypothesis that myocardial scars after repair of tetralogy of Fallot are related to impaired cardiac function and adverse clinical outcome. A total of 53 patients were retrospectively analysed after repair of tetralogy of Fallot. The median patient age was 20 years (range 2-48). Cardiac MRI with a ...
Pedersen Frants F Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, - - 2014
Short-term mortality has been studied thoroughly in patients undergoing primary percutaneous coronary intervention (PCI), whereas long-term cause of death in patients with ST-segment elevation myocardial infarction (STEMI) remains unknown. The goal of this study was to describe the association between time and cause of death in patients with STEMI undergoing ...
Liu Juan J Department of Internal Medicine, Tianjin Union Medicine Center & Tianjin People's Hospital, Tianjin, - - 2014
Myocardial infarction is a fatal cardiovascular disease and one of the most common death causes all around the world. The aim of the meta-analysis was to quantify the risk of myocardial infarction associated with Helicobacter pylori infection. A literature search was performed to identify studies published before 14 July, 2014, ...
Ohlow Marc-Alexander MA Cardiology Clinic, Zentralklinik Bad Berka, 99437 Bad Berka, Germany. Electronic address: - - 2014
Absence of significant epicardial coronary artery stenosis in patients with acute onset of chest pain and elevation of myocardial necrosis markers is occasionally observed. The aim of this study was to retrospectively analyze the clinical characteristics and the outcome of such patients. All patients with myocardial infarction (MI) but without ...
Zeymer U U Klinikum Ludwigshafen, Bremser Str. 79, 67063, Ludwigshafen, Germany, - - 2014
Representative data on the current management of patients with acute coronary syndromes (ACS) are of high interest. The EPICOR registry aimed to prospectively collect such real-life data with particular focus on antithrombotic drug utilization and outcomes. As part of the international prospective EPICOR registry, 29 hospitals in Germany documented 296 ...
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