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Results 51 - 100 of 1159
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Ji Mi Seon MS Chonnam National University Hospital, Gwangju, Republic of - - 2014
Despite good treatment, there are residual risks in acute myocardial infarction (AMI) patients, and low level of high-density lipoprotein-cholesterol (HDL) has drawn attention as a possible cause. However, the impact of low HDL on ST-segment-elevation myocardial infarction (STEMI) compared with non-ST-segment-elevation myocardial infarction (NSTEMI) is not clear. Our aim was ...
Mark Daniel B - - 2014
The STICH (Surgical Treatment for Ischemic Heart Failure) trial compared a strategy of routine coronary artery bypass grafting (CABG) with guideline-based medical therapy for patients with ischemic left ventricular dysfunction. To describe treatment-related quality-of-life (QOL) outcomes, a major prespecified secondary end point in the STICH trial. Randomized trial. (ClinicalTrials.gov: NCT00023595). ...
Kilickesmez Kadriye Orta KO aDepartment of Cardiology, Istanbul University Institute of Cardiology bDepartment of Biochemistry, Istanbul University Medical Faculty, Istanbul, - - 2014
Spontaneous reperfusion (SR) was associated with better clinical outcomes and lower incidence of major adverse cardiovascular events. Endothelin-1 (ET-1) is a potent endothelium-derived vasoconstrictor peptide and elevated systemic ET-1 levels predict a poor prognosis in patients with ST-segment elevation myocardial infarction (STEMI). We aimed to investigate the relationship between systemic ...
MacCallum Caroline C Melbourne Brain Centre at Royal Melbourne Hospital, Melbourne, - - 2014
Background: Early decompressive hemicraniectomy following malignant middle cerebral artery (MCA) infarction reduces mortality and improves clinical outcome. Imaging predictors of malignant infarction may serve as 'red flags', prompting intensive neurological monitoring and timely intervention. Our objective is to investigate whether lower ASPECTS (Alberta Stroke Program Early CT Score) is associated ...
Child Nicholas - - 2014
Myocardial crypts are discrete clefts or fissures in otherwise compacted myocardium of the left ventricle (LV). Recent reports suggest a higher prevalence of crypts in patients with hypertrophic cardiomyopathy (HCM) and also within small samples of genotype positive but phenotype negative relatives. The presence of a crypt has been suggested ...
Chitose Tadasuke T Department of Cardiovascular Medicine, Faculty of Life Sciences, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto City 860-8556, Japan; Social Insurance Omuta-Tenryo Hospital, 1-100 Tenryo, Omuta City Fukuoka 836-8566, Japan. Electronic address: - - 2014
Early statin therapy after acute coronary syndrome reduces atherothrombotic vascular events. This study aimed to compare the effects of hydrophilic and hydrophobic statins on myocardial salvage and left ventricular (LV) function in patients with ST-elevated myocardial infarction (STEMI). Seventy-five STEMI patients who had received emergency reperfusion therapy were enrolled and ...
Ertelt Konstanze K Cardiovascular Research Foundation, New York, NY, - - 2014
Family history of coronary artery disease (CAD) is a well-established risk factor of future cardiovascular events. The authors sought to examine the relationship between family history of CAD and clinical profile and prognosis of patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). Baseline features and clinical ...
Puymirat Etienne E Departement of Cardiology, European Hospital of Georges Pompidou, Assistance Publique des Hôpitaux de Paris (AP-HP), University Paris Descartes, Paris, France; INSERM U-970, Paris, France. Electronic address: - - 2014
Results from randomized trials evaluating thrombus aspiration (TA) in patients with ST-elevation myocardial infarction (STEMI) are conflicting. We assessed 1-year survival in STEMI patients participating in the French Registry of Acute ST-Elevation and non-ST-Elevation Myocardial Infarction (FAST-MI) 2010 according to the use of TA during primary percutaneous coronary intervention (PCI). ...
Gong Jingjing J a Department of Neurology , General Hospital of Beijing Command PLA , Beijing , - - 2014
Numerous studies have found that the framing effect is common in medical scenarios, but few studies have examined the influence of the framing effect upon thrombolytic therapy for cerebral infarction. In this study, 1040 inpatients and outpatients in the department of neurology were recruited to explore whether there is a ...
Kristensen Karl E KE Department of Cardiology, Gentofte University Hospital, - - 2014
Clopidogrel is an oral antiplatelet prodrug, the majority of which is hydrolyzed to an inactive metabolite by hepatic carboxylesterase 1 (CES1). Most angiotensin-converting enzyme inhibitors (ACEIs) are also metabolized by this enzyme. We examined effects of ACEIs on clopidogrel bioactivation in vitro and linked the results with a pharmaco-epidemiological study. ...
Gjesing Anne A Department of Cardiology, Niels Andersens Vej 65, Gentofte University Hospital, 2900 Hellerup, Denmark. Electronic address: - - 2014
Pharmacological and revascularization strategies following myocardial infarction (MI) have changed substantially during the last two decades. We investigated the temporal trends in heart failure (HF) incidence and mortality during the first 90days following first-time MI between 1997 and 2010 in Denmark. Through administrative nationwide registers we identified 89,389 patients without ...
Paiva Luis L Coimbra's Hospital and University Centre, Coimbra, Portugal. Electronic address: - - 2014
Risk assessment is fundamental in the management of acute coronary syndromes (ACS), enabling estimation of prognosis. To evaluate whether the combined use of GRACE and CRUSADE risk stratification schemes in patients with myocardial infarction outperforms each of the scores individually in terms of mortality and haemorrhagic risk prediction. Observational retrospective ...
Symons Rolf R From the Departments of Radiology (R.S., K.D., J.B.) and Cardiovascular Diseases (K.G., S.J.), Gasthuisberg University Hospital, Herestraat 49, Leuven BR 3000, Belgium; and Department of Cardiology, Fondazione CNR/Regione Toscana G. Monasterio, Pisa, Italy - - 2014
Purpose To evaluate the relationship between myocardial infarction (MI) severity at magnetic resonance (MR) imaging and regional and global postinfarction left ventricular (LV) remodeling. Materials and Methods This HIPAA-compliant study was institutional review board approved. In 186 patients, reperfused ST segment elevation MI (mean age ± standard deviation, 59 years ...
Helve Salla - - 2014
Treatment delay is an important prognostic factor for patients with acute ST-elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI). We aimed to determine recent trends in these delays and factors associated with longer delays. We compared two datasets collected in Helsinki University Central Hospital in 2007-2008 (HUS-STEMI ...
O'Donoghue Michelle L ML TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Boston, - - 2014
Lipoprotein-associated phospholipase A2 (Lp-PLA2) has been hypothesized to be involved in atherogenesis through pathways related to inflammation. Darapladib is an oral, selective inhibitor of the Lp-PLA2 enzyme. To evaluate the efficacy and safety of darapladib in patients after an acute coronary syndrome (ACS) event. SOLID-TIMI 52 was a multinational, double-blind, ...
Shacham Yacov Y Department of Cardiology, Tel-Aviv Sourasky Medical Center Affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, 6 Weizman Street, 64239, Tel Aviv, Israel, - - 2014
Acute kidney injury (AKI) is associated with adverse outcomes after acute ST elevation myocardial infarction (STEMI). The recently proposed AKI network (AKIN) suggested modifications to the consensus classification system for AKI known as the risk, injury, failure, loss, end-stage (RIFLE) criteria. The aim of the current study was to compare ...
Doltra Adelina A Thorax Institute, Hospital Clinic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain. Electronic address: - - 2014
Our aim was to identify "correctable abnormalities" using conventional grayscale and blood-pool Doppler echocardiography and evaluate their ability to predict both response and midterm survival. Identification of mechanical abnormalities that may be corrected with cardiac resynchronization therapy (CRT) is useful for predicting echocardiographic response at 1-year follow-up. A total of ...
Li Meihua M Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, - - 2014
Modulation of vagal tone using electrical vagal nerve stimulation or pharmacological acetylcholinesterase inhibition by donepezil exerts beneficial effects in an animal model of chronic heart failure (CHF). Considering different treatment mechanisms underlying renin-angiotensin system (RAS) suppression and parasympathetic activation, we hypothesized that parasympathetic activation together with RAS inhibition could attenuate ...
Katsikis Athanasios A Nuclear Medicine Department, Onassis Cardiac Surgery Center, Athens, Greece, - - 2014
Although the use of myocardial perfusion imaging (MPI) for prognostic purposes in general population is well understood, its role in very elderly patients is not extensively studied. 247 octgogenarians (79% male, 56% previous myocardial infarction-MI or revascularization) who underwent treadmill exercise testing (TET) with MPI were studied. TET and MPI-related ...
Guisado Espartero María Esther ME Department of Internal Medicine, Hospital Infanta Margarita, Avenida Góngora s/n, CP: 14940 Cabra, Córdoba, Spain. Electronic address: - - 2014
Elevated troponin in heart failure has been associated with worse prognosis, but there are differences in the design and results of published studies. Our objective was to determine the association of troponin T with mortality and readmissions in patients with acute heart failure in clinical practice conditions. We included patients ...
Su Mao-Yuan M MY Department of Medical Imaging, National Taiwan University Hospital, Taipei, - - 2014
To investigate diffuse myocardial fibrosis in patients with systolic heart failure (SHF) and in patients with heart failure with preserved ejection fraction (HFpEF) and the association with diastolic dysfunction of the left ventricle (LV). Increased diffuse myocardial fibrosis may impair LV diastolic function. However, no study has verified the association ...
Rimoldi Ornella O aMedical Research Council Clinical Sciences Centre bNational Heart and Lung Institute Imperial College, London, UK cCNR IBFM, Segrate dVita-Salute University and Scientific Institute IRCCS San Raffaele, Milan, - - 2014
Hypertensive patients show a blunted coronary flow reserve (CFR) that, in the absence of epicardial disease, is an index of microvascular dysfunction. We aimed at assessing subendocardial and subepicardial myocardial blood flow (MBF) and CFR using high-resolution PET and determine the influence of haemodynamic load and ventricular mass in patients ...
Baker E H EH From the Department of Radiology and Imaging Sciences (E.H.B.), Clinical Center, and Genetics and Molecular Biology Branch (J.L.S., I.M., C.P.V.), Medical Genetics Branch (D.R.A.), and Undiagnosed Diseases Program (C.T.), National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland; Medical Genetics and Metabolism Department (N.S.H.), Children's Hospital Central California, Madera, California; and Department of Neurology (A.L.G.), Children's National Medical Center, Washington, DC. - - 2014
Bilateral infarcts confined to the globus pallidus are unusual and occur in conjunction with only a few disorders, including isolated methylmalonic acidemia, a heterogeneous inborn error of metabolism. On the basis of neuroradiographic features of metabolic strokes observed in a large cohort of patients with methylmalonic acidemia, we have devised ...
Lin Aaron A Department of Cardiology, Middlemore Hospital, Auckland, New - - 2014
Risk stratification after acute coronary syndrome (ACS) event is recommended to guide intensity and timing of investigation and management. The Global Registry of Acute Coronary Events (GRACE) investigators have published several scores for predicting patient risk both at hospital admission and discharge. To evaluate the performance of the admission-to-6-month and ...
Sanchis Laura L Cardiology Department, Thorax Institute, Hospital Clinic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Villarroel Street 170, Barcelona 08036, Spain - - 2014
Pathophysiology of heart failure (HF) with preserved ejection fraction (HFPEF) remains unclear. Left atrial (LA) function has been related to HF symptoms. Our purpose is to analyse LA function in outpatients with new onset symptoms of HF. An observational study was performed including 138 consecutive outpatients with suspected HF referred ...
Chen C-H CH Division of infectious disease, department of internal medicine, Changhua-Christian hospital, 135, Nanhsiau street, Changhua, Taiwan, Republic of China; Department of Nursing, College of Medicine & Nursing, Hung Kuang University, Taichung, Republic of China. Electronic address: - - 2014
Cerebral infarction in tuberculous meningitis is a major risk factor for permanent disability. This study assessed the clinical presentation of tuberculous meningitis and risks factors for cerebral infarction. Thirty-eight adult patients with tuberculous meningitis were studied between 2002 and 2006. Clinical, radiological, and laboratory data of patients with cerebral infarction ...
Huang Xin-Sheng XS Department of Cardiac Surgery, Beijing An Zhen Hospital, Capital Medical University, Beijing, - - 2014
The aim of the study was to detect whether the systolic dyssynchrony index (SDI) assessed by real-time 3D echocardiography (RT3DE) could predict clinical outcomes of patients with ventricular aneurysm in response to surgical ventricular reconstruction (SVR). In total, 120 individuals underwent RT3DE, including 30 healthy volunteers and 90 patients with ...
Lee Keon-Joo KJ Department of Neurology, Laboratory for Neurotherapeutics, Biomedical Research Institute, Seoul National University Hospital, Seoul, South - - 2014
Background: Cerebral arterial occlusion develops via two distinct mechanisms: thrombosis and embolism. Discrimination between thrombosis and embolism is an important aspect needed for further determining the etiology of stroke in a patient. This study evaluated infarct patterns and outcomes in acute stroke patients with relevant artery occlusions, focusing on features ...
Loh Joshua P JP Interventional Cardiology, MedStar Washington Hospital Center, Washington, - - 2014
Bleeding after percutaneous coronary intervention (PCI) is identified as a strong predictor for adverse events, including mortality. This study aims to compare the incidence and correlates of post-PCI bleeding across different clinical presentations. The study included 23,943 consecutive PCI patients categorized according to their clinical presentation: stable angina pectoris (n ...
Vale Noah N Family Medicine, St Mary's Hospital, McGill University, 377 Rue Jean Brilliant, Montreal, QC, Canada, H3T - - 2014
The early period following the onset of acute coronary syndrome (ACS) represents a critical stage of coronary heart disease, with a high risk of recurrent events and deaths. The short-term effects of early treatment with statins on patient-relevant outcomes in patients suffering from ACS are unclear. This is an update ...
Akyürek Omer O Department of Internal Medicine, Mevlana University Hospital, Konya, Turkey. Electronic address: - - 2014
The present study aimed to investigate the relationship between coagulation defects and ST elevation myocardial infarction (STEMI) in patients without any known coronary artery risk factors and considered low risk according to the Framingham risk classification. This study included 76 (73.6% male) STEMI patients without any known risk factors for ...
Kedev Sasko S University Clinic of Cardiology, Interventional Cardiology, Vodnjanska 17, Skopje, Macedonia 1000. - - 2014
To compare the short- and long-term outcomes of transradial approach (TRA) versus transfemoral approach (TFA) for primary percutaneous coronary intervention (PPCI) during a complete institutional transition from TFA to TRA. An all-comer population of ST-elevation myocardial infarction (STEMI) patients (n=1808) who underwent PPCI using TRA (n=1162) and TFA (n=646) from ...
Patel Niket N Cardiology Department, Oxford Heart Centre, Oxford University Hospitals, Oxford, United - - 2014
This study sought to evaluate in-hospital outcomes and 3-year mortality of patients presenting with unprotected left main stem occlusion (ULMSO) treated with primary percutaneous coronary intervention (PPCI). Limited data exists about management and outcome following presentation with ULMSO. From January 1, 2007 to December 21, 2012, 446,257 PCI cases were ...
Yang Li-Xia LX Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, NO. 2 Anzhen Avenue, Chaoyang District, Beijing 100029, - - 2014
Few studies have compared change in the health-related quality of life (HRQL) following treatment of non-ST-elevation acute coronary syndrome (NSTE-ACS) with either percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG). This study is to compare changes in HRQL six months after hospital discharge between NSTE-ACS patients who underwent ...
Vyas Ankur A Division of Cardiovascular Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA. - - 2014
A 600-mg loading dose (LD) of clopidogrel has been shown to be superior to a 300-mg LD in inhibiting platelet function. However, data for clinical superiority are limited, and there is a paucity of adequately powered randomized trials investigating this issue. This meta-analysis was performed to determine the optimal LD ...
De Bruyne Bernard B The authors' affiliations are listed in the - - 2014
We hypothesized that in patients with stable coronary artery disease and stenosis, percutaneous coronary intervention (PCI) performed on the basis of the fractional flow reserve (FFR) would be superior to medical therapy. In 1220 patients with stable coronary artery disease, we assessed the FFR in all stenoses that were visible ...
Kim Sung Eun SE Cardiology Division, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, - - 2014
The non-invasive differentiation of ischemic and nonischemic acute heart failure (AHF) not resulting from acute myocardial infarction is difficult and has therapeutic and prognostic implications. The aim of this study was to assess whether resting myocardial contrast echocardiography (MCE) can detect coronary artery disease (CAD) in patients with decreased left ...
Murray Gary L GL Director Medical Research, Heart and Vascular Institute, Germantown, - - 2014
Normal myocardial perfusion imaging (MPI) reduces intermediate- or high-risk pretest probability patients to low- or intermediate-risk posttest probability, respectively, for coronary disease (CD). Since ranolazine (RAN) relieves only angina, anginal patients with normal MPI whose angina is relieved by RAN present a significant dilemma. The purpose of this retrospective chart ...
Dharma Surya S Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, - - 2014
The appropriate timing of eptifibatide initiation for acute ST segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI) remains unclear. This study aimed to analyze the impact of timing of eptifibatide administration on infarct-related artery (IRA) patency in STEMI patients undergoing primary PCI. Acute STEMI patients who ...
Gili Sebastiano S Division of Cardiology, Department of Internal Medicine, Città della Salute e della Scienza, Turin, - - 2014
Different definitions of periprocedural myocardial infarction (MI) after percutaneous coronary intervention (PCI) have been provided, but their impact on prognosis remains to be determined. Procedural data from consecutive patients undergoing PCI from 2009 to 2011 were revised to adjudicate diagnosis of periprocedural MI according to CK-MB increase (>3 × URL and >5 × URL), ...
Arbel Yaron Y Department of Cardiology, Tel Aviv Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address: - - 2014
High RDW values are associated with adverse prognosis in many clinical conditions including short and medium term outcome of patients with ST Elevation Myocardial Infarction (STEMI). The aim of the present study was to evaluate the association between RDW and long term mortality in STEMI patients undergoing primary angioplasty (PPCI). ...
Muschitz Gabriela K GK Division of Plastic and Reconstructive Surgery, Department of Surgery, Medical University Vienna, Vienna, Austria. Electronic address: - - 2014
Gastrointestinal complications occur frequently in intensive care patients with severe burns. Intestinal infarction and its deleterious consequences result in high mortality despite rapid surgical intervention. Our objective was to evaluate the aetiology of gastrointestinal infarction in intensive care patients with severe burns. We retrospectively evaluated all of the severe-burn victims ...
Mamas Mamas A MA Manchester Heart Centre, Manchester Royal Infirmary, Manchester, UK Cardiovascular Research Group, Institute of Cardiovascular Sciences, University of Manchester, Manchester, - - 2014
Between 10 and 30% of patients undergoing percutaneous coronary intervention (PCI) have left ventricular (LV) dysfunction. We investigate the association between LV function on early and late mortality outcomes in a national 'real-world' cohort undergoing PCI in the elective and acute coronary syndrome setting through analysis of the British Cardiovascular ...
Grodin Justin L JL Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195. Electronic address: - - 2014
Over the years several methods have been developed to reliably quantify functional capacity in patients with heart failure. Few studies have investigated the prognostic value of these assessment tools beyond cardio-renal prognostic biomarkers in stable patients with chronic heart failure. We performed Duke Activity Status Index (DASI, a self assessment ...
Orban M M Martin Orban, MD, Medizinische Klinik und Poliklinik I, Klinikum der Universität München, Campus Großhadern, Ludwig-Maximilians-Universität München, Marchioninistr. 15, 81377 München, Germany, Tel.: +49 89 7095 2361, Fax: +49 89 7095 8830, E-mail: - - 2014
There is limited clinical data comparing different P2Y12-receptor inhibitors in patients with acute myocardial infarction (AMI) complicated by cardiogenic shock. The aim of the ISAR-SHOCK registry was to compare the clinical outcome of patients treated with clopidogrel vs prasugrel in this setting. Patients (n=145) with AMI complicated by cardiogenic shock ...
Kitagawa K K Department of Neurology, Tokyo Women's Medical University, Tokyo, - - 2014
The association between vascular risk factors and dementia is of interest. Several studies have shown that cerebral small vessel disease (SVD) is associated with dementia. However, the association between cerebral large vessel disease (LVD) and dementia has not been thoroughly examined. The Osaka Follow-up Study for Carotid Atherosclerosis, Part 2, ...
Pöyhönen Pauli - - 2014
Suspected nonischemic cardiomyopathy (NICM) is a common clinical setting with highly variable prognosis. Early noninvasive risk-stratification is important for justification of invasive examinations, specific treatment and patient surveillance. We studied the additional prognostic value of late gadolinium enhancement (LGE) and segmental wall motion abnormality (SWMA) extent on cardiovascular magnetic resonance ...
Hoogslag Georgette E GE Department of Cardiology, Leiden University Medical Center, Leiden, The - - 2014
Right ventricular (RV) function after ST-segment elevation myocardial infarction (STEMI) has important prognostic implications. However, the changes in RV function over time after STEMI and the incidence of RV remodeling remain unknown. The present study evaluated changes in RV dimensions and function in contemporary patients with first STEMI and assessed ...
Szpakowicz Anna A Department of Cardiology, Medical University of Bialystok, M. Sklodowskiej-Curie 24a, 15-276, Bialystok, - - 2014
Paraoxonase 1 (PON1) is an enzyme responsible for the antioxidant properties of high density lipoprotein (HDL). The activity of PON1 is decreased in patients with coronary artery disease, myocardial infarction or chronic kidney disease. rs662 and rs854560 are single nucleotide polymorphisms (SNPs) associated with PON1 activity and 10-year cardiovascular mortality ...
Bates Eric R ER University of Michigan Medical Center, Ann Arbor, MI - - 2014
Placebo-controlled trials with fibrinolytic agents first demonstrated important reductions in morbidity and mortality when reperfusion therapy was administered to patients with ST-segment elevation myocardial infarction (STEMI).(1,2) Although primary percutaneous coronary intervention (PCI) is a better reperfusion strategy when compared with fibrinolytic therapy in randomized clinical trials,(3) geographic access and logistical ...
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