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Yu Hou-You HY Department of Emergency Medicine, Xijing hospital, Fourth Military Medical University, No.17 Changle West Road, Xi'an, 710032, P.R. - - 2014
Adropin is a recently identified bioactive protein that is important for energy homeostasis and maintaining insulin sensitivity. We sought to detect serum adropin levels in acute myocardial infarction (AMI) patients. We enrolled 138 AMI patients, 114 stable angina pectoris (SAP) patients and 75 controls. Adropin levels were measured by enzyme-linked ...
Rosin Nicole L - - 2014
Myocardial fibrosis is a pathological process that is characterized by disrupted regulation of extracellular matrix proteins resulting in permanent scarring of the heart tissue and eventual diastolic heart failure. Pro-fibrotic molecules including transforming growth factor-beta and connective tissue growth factor are expressed early in the AngiotensinII (AngII)-induced and other models ...
Liu Yuting Y 1 The Second Affiliated Hospital of Harbin Medical University , Harbin, China - - 2014
Abstract Objective: To analyze changes in cardiac function indices after electroacupuncture (EA) at the pericardium 6 (PC-6) acupoint using the equilibrium radionuclide angiocardiography (ERNA) quantity analysis technique. Design: Analysis of clinical outcomes after EA at PC-6 measured by ERNA. Setting: The study was conducted in a hospital. Participants: 31 participants ...
Nishii Tatsuya T Department of Radiology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, - - 2014
Myocardial edema and inflammation play an important role in dilated cardiomyopathy (DCM). This pathologic condition can be identified noninvasively using cardiovascular magnetic resonance imaging (CMR). The purpose of this study was to determine the effectiveness of T2 values obtained with T2 mapping in the detection of edema in DCM patients, ...
Zeng Jinming J Department of Anesthesia of Cardiovascular Institute, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi. Electronic address: - - 2014
The purpose of this article was to systematically review randomized controlled trials in which cold blood cardioplegia was compared with cold crystalloid cardioplegia for cardiac surgery. Correlation studies were searched independently in the EMBASE, MEDLINE and Cochrane library databases. The primary endpoints of interest were spontaneous sinus rhythm (SSR) after ...
McDermott Mary M MM Department of Medicine, Northwestern University Feinberg School of Medicine; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine. Electronic address: - - 2014
Basic research suggests that rapid increases in circulating inflammatory and hemostatic blood markers may trigger or indicate impending plaque rupture and coronary thrombosis, resulting in acute ischemic heart disease (IHD) events. However, these associations are not established in humans. The Biomarker Risk Assessment in Vulnerable Outpatients (BRAVO) Study will determine ...
Rambihar Sherryn S Division of Cardiology, University of Toronto, Toronto, Ontario, - - 2014
The submitral apparatus maintains annular-papillary continuity and myocardial geometry. In mitral valve prolapse (MVP), elongated chords and redundant leaflets can interact at the region of myocardial attachment, leading to apparent discordant motion of the basal inferolateral wall. The aim of this study was to test the hypothesis that basal inferolateral ...
Masaki Mitsuru M Cardiovascular Division, Department of Internal Medicine, Hyogo College of - - 2014
Background: Thyroid hormone is associated with arterial stiffness and left ventricular diastolic function in hypothyroid disease. The relationship of thyroid hormone level to cardio-ankle vascular index (CAVI) and left ventricular diastolic function, however, remains unclear in subjects with subclinical hypothyroidism. Methods and Results: We conducted a cross-sectional study of 83 patients with ...
Visser Marlieke M Departments of Surgery (MV, WW, and PAMvL), Clinical Chemistry (MD and TT), and Epidemiology and Biostatistics (MAJ), VU University Medical Center, Amsterdam, Netherlands, and the Departments of Cardio-thoracic Surgery (MV, RC, and BAJMdM), Nuclear Medicine (HJV), Cardiology (WEMK), and Pharmacy (EMK) and the Intensive Care Unit (RT), Academic Medical Center University of Amsterdam, Amsterdam, - - 2014
Nitric oxide (NO) is essential for the optimal perfusion of the heart and its vasculature. NO may be insufficient in surgical patients because its precursor arginine is decreased, and the inhibitor of NO synthesis asymmetric dimethylarginine (ADMA) is increased. Besides arginine, the presence of other amino acids essential for the ...
Liu Daliang D Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. - - 2014
The aim of the present study was to investigate the predictive value of multi-detector computed tomography angiography (MDCTA) on acute coronary artery events in patients with type 2 diabetes mellitus (T2DM). MDCTA was performed in 150 patients with T2DM (males, 74; mean age, 66±6.7 years for all patients) that had ...
Ozdemir Didem D Department of Endocrinology and Metabolism, Ataturk Education and Research Hospital, Yildirim Beyazit University, Ankara, Turkey, - - 2014
Cardiovascular morbidity and mortality are increased in patients with primary hyperparathyroidism (PHPT). We aimed to evaluate left ventricle systolic and diastolic functions with tissue Doppler imaging (TDI) and strain and strain rate echocardiography in patients with PHPT. Thirty-one patients with PHPT and 29 healthy controls were evaluated with conventional and ...
Desai Ankit A AA 1Department of Medicine, University of Illinois Hospitals and Health Sciences System, Chicago, - - 2014
-Cardiovascular disease is an important cause of morbidity and mortality in sickle cell disease (SCD). We sought to characterize sickle cell cardiomyopathy using multi-modality non-invasive cardiovascular testing and identify potential causative mechanisms. -Stable adults with SCD (n=38) and healthy controls (n=13) prospectively underwent same day multi-parametric cardiovascular magnetic resonance (cine, ...
Pizarro Gonzalo G Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain; Hospital Universitario Quirón-Universidad Europea de Madrid, - - 2014
To study the long-term effects of i.v. metoprolol administration before reperfusion on left ventricular (LV) function and clinical events. Early i.v. metoprolol during ST-segment elevation myocardial infarction (STEMI) has been shown to reduce infarct size when used in conjunction with primary percutaneous coronary intervention (pPCI). The METOCARD-CNIC trial recruited 270 ...
Nagata Hazumu H Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka City, 812-8582, Japan, - - 2014
Pathologic studies of the heart in patients with Kawasaki disease (KD) revealed vasculitis, valvulitis, myocarditis, and pericarditis. However, there have been no studies on the quantitative determination of multi-site echogenicity of the heart in KD patients. It is also undetermined whether the degree of echogenicity of each site of the ...
Zhang Jing J 1Department of Cardiovascular Medicine, the First Affiliated Hospital, and the Ministry of Health Key Laboratory of Assisted Circulation, Sun Yat-Sen University, Guangzhou, China, and 2 Department of Ultrasonography, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, - - 2014
To investigate the effects and mechanisms of nardostachys chinensis on spontaneous ventricular arrhythmias in rats with hyper-acute myocardial infarction (AMI). Seventy-two rats were randomly divided into the control group (n=24), metoprolol group (n=24) and the NC group (n=24). Premature ventricular contractions (PVCs), ventricular tachycardias (VTs), ventricular fibrillations (VFs) and blood ...
Duchateau Nicolas N Arrythmia, Resynchronization and Cardiac Imaging Unit, Hospital Clínic, Universitat de Barcelona, Calle Villaroel 170, 08036, Barcelona, Spain, - - 2014
In cardiac resynchronization therapy (CRT), specific changes in motion/deformation happen with left-bundle-branch-block (LBBB) and following treatment. However, they remain sub-optimally studied. We propose a two-fold improvement of their characterization. This includes controlling them through an experimental model and using more suitable quantification techniques. We used a swine model of acute ...
Batlle M M Biomedical Research Institute August Pi i Sunyer (IDIBAPS), Spain; Thorax Institute, Cardiology Department, Hospital Clínic de Barcelona, Spain. Electronic address: - - 2014
AXL is a membrane receptor tyrosine kinase highly expressed in the heart and has a conspicuous role in cardiovascular physiology. The role of AXL in heart failure (HF) has not been previously addressed. AXL protein was enhanced 6-fold in myocardial biopsies of end-stage HF patients undergoing heart transplantation compared to ...
Nelson Michael D D MD 1Heart Institute, Cedars-Sinai Medical Center, Los Angeles, - - 2014
-Angina, in the absence of obstructive CAD is more common in women, is associated with adverse cardiovascular morbidity and mortality, and is a major burden to the healthcare system. While advancements have been made to understand the mechanistic underpinning of this disease, the functional consequence remains unclear. -Cardiac magnetic resonance ...
Sengupta Shantanu P SP Sengupta Hospital and Research Institute, Nagpur, - - 2014
Previous studies have reported abnormal left ventricular (LV) contraction in patients with mitral stenosis (MS). The aim of this study was to explore the serial changes in LV mechanics in patients with severe MS undergoing balloon mitral valvuloplasty (BMV) to understand the reversibility and determinants of abnormal LV contractile function. ...
Li Shu-Juan SJ Division of Paediatric Cardiology, Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, - - 2014
Differences in systemic venous flow dynamics and energy losses exist in various Fontan-type procedures, which may affect atrial and ventricular filling. The aim of this study was to test the hypothesis that atrial and ventricular mechanics differ between two types of Fontan procedures, atriopulmonary connection (APC) and extracardiac conduit, which ...
Storto G G IRCCS, CROB, Rionero in Vulture, Potenza, Italy - - - 2014
AIM:Patients with hypertension may exhibit abnormal vasodilator capacity during pharmacological vasodilatation. We assessed coronary flow reserve (CFR) by sestamibi imaging in hypertensive patients with normal coronary vessels. Twenty-five patients with untreated mild essential hypertension and normal coronary vessels and 10 control subjects underwent dipyridamole-rest Tc-99m sestamibi imaging. Myocardial blood flow ...
Gabbay Uri U Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; School of Electrical Engineering, Tel Aviv University, Tel Aviv, Israel. Electronic address: - - 2014
Heart failure (HF) and shock are incomprehensively understood, inconclusively defined and lack a single conclusive test. The proceedings that preceded and triggered clinical manifestations are occult. The relationships in between different shock and HF types and between each HF type and its matched shock are poorly understood. We suggest that ...
Huang Suli S 1Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, - - 2014
-Circulating microRNAs (miRNAs) are emerging as novel disease biomarkers. We aimed to explore the association between circulating miRNAs and the occurrence of acute myocardial infarction (AMI) in Chinese populations. -In the discovery stage, the plasma of 20 AMI patients and 20 controls were pooled respectively and profiled by massively parallel ...
Mahfoud Felix F Klinik für Innere Medizin III, Universitätsklinikum des Saarlandes, Homburg/Saar, - - 2014
Sympathetic stimulation induces left ventricular hypertrophy and is associated with increased cardiovascular risk. Catheter-based renal denervation (RDN) has been shown to reduce sympathetic outflow and blood pressure (BP). The present multi-centre study aimed to investigate the effect of RDN on anatomic and functional myocardial parameters, assessed by cardiac magnetic resonance ...
Ntusi Ntobeko Ab - - 2014
Systemic sclerosis (SSc) is characterised by multi-organ tissue fibrosis including the myocardium. Diffuse myocardial fibrosis can be detected non-invasively by T1 and extracellular volume (ECV) quantification, while focal myocardial inflammation and fibrosis may be detected by T2-weighted and late gadolinium enhancement (LGE), respectively, using cardiovascular magnetic resonance (CMR). We hypothesised ...
Taylor Edwin W EW Departamento de Zoologia, Instituto de Biociências, Universidade Estadual Paulista, Campus Rio Claro, São Paulo 13506-900, - - 2014
Heart rate in vertebrates is controlled by activity in the autonomic nervous system. In spontaneously active or experimentally prepared animals, inhibitory parasympathetic control is predominant and is responsible for instantaneous changes in heart rate, such as occur at the first air breath following a period of apnoea in discontinuous breathers ...
Ziabakhsh-Tabary Shervin S Department of Cardiac Surgery, Fatemeh Zahra Hospital, Mazandaran University of Medical Sciences, Sari, - - 2014
Background: Erythropoietin (EPO) is known as a regulating hormone for the production of red blood cells, called erythropoiesis. Some studies have shown that EPO exerts some non-hematopoietic protective effects on ischemia-reperfusion injuries in myocytes. Using echocardiography, we evaluated the effect of EPO infusion on reducing ischemia-reperfusion injuries and improvement of ...
Huh In Young IY Department of Anesthesiology and Pain Medicine, Ulsan University Hospital, Ulsan, - - 2014
A prolonged QT interval can lead to malignant ventricular arrhythmias and sudden cardiac death, and has frequently been found in end-stage liver disease (ESLD). However, myocardial repolarization lability has not yet been fully investigated. We evaluated the QT variability index (QTVI), a marker of temporal inhomogeneity in ventricular repolarization and ...
Roubille F F Department of Cardiology, UMR5203, UMR661, Institut de Génomique Fonctionnelle, Universités Montpellier 1 and 2, Montpellier, - - 2014
Proof-of-concept evidence suggests that mechanical ischaemic post-conditioning (PostC) reduces infarct size when applied immediately after culprit coronary artery re-opening in ST-elevation myocardial infarction (STEMI) patients with thrombolysis in myocardial infarction 0-1 (TIMI 0-1) flow grade at admission. Whether PostC might also be protective in patients with a TIMI 2-3 flow ...
Kuloglu Tuncay T Firat University, School of Medicine, Department of Histology and Embryology, Elazig 23119, - - 2014
Myocardial infarction (MI) causes energy depletion through imbalance between coronary blood supply and myocardial demand. Irisin produced by the heart reduces ATP production by increasing heat generation. Energy depletion affects irisin concentration in circulation and cardiac tissues, suggesting an association with MI. We examined: 1) irisin expression immunohistochemically in rat ...
Florian Anca A Department of Cardiology and Angiology, University Hospital Münster, Münster, - - 2014
This study investigated the safety profile and potential "therapeutic" effect of intravenous ultrasmall superparamagnetic iron-oxide (USPIO)-based iron administration regarding infarct healing in patients with ST-elevation myocardial infarction (STEMI). USPIO-administration was recently shown to enable an improved characterization of myocardial infarct pathology in acute STEMI patients. Seventeen study patients (IRON, 54±9yrs, ...
Ravn Nathja - - 2014
Abstract Objectives: We aimed to develop a porcine model for chronic non-ischemic mitral regurgitation (MR) to investigate left ventricular (LV) enlargement and eccentric hypertrophy. Design: Non-ischemic MR was induced in 30 pigs by open chest immobilization of the posterior mitral leaflet by transannular traction sutures that where applied in transmyocardial ...
Pätilä Tommi T Department of Cardiothoracic - - 2014
Bone marrow mononuclear cell (BMMC) transplantation for heart failure has shown inconsistent therapeutic efficacy. We enrolled 104 ischemic heart failure patients scheduled for coronary artery bypass surgery (CABG). After 4- to 12-week pharmacotherapy optimization, 39 patients with left ventricular ejection fraction (LVEF) of ≤45% received injections of BMMC or vehicle ...
Eckhouse Shaina R SR Cardiothoracic Surgery, Medical University of South Carolina, Charleston, SC 29425, - - 2014
An imbalance between matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) contributes to the left ventricle (LV) remodeling that occurs after myocardial infarction (MI). However, translation of these observations into a clinically relevant, therapeutic strategy remains to be established. The present study investigated targeted TIMP augmentation through regional injection ...
Dalager-Pedersen Michael M Aalborg University Hospital, Aalborg; Aarhus University Hospital, Aarhus, - - 2014
Infections may trigger acute cardiovascular events, but the risk after community-acquired bacteremia is unknown. We assessed the risk for acute myocardial infarction and ischemic stroke within 1 year of community-acquired bacteremia. Population-based cohort study in Northern Denmark. We included 4389 hospitalized medical patients with positive blood cultures obtained on the ...
Ro Sun Kyun SK Department of Thoracic and Cardiovascular Surgery, Hanyang University Guri Hospital, Seoul, South - - 2014
Intra-aortic balloon counterpulsation (IABP) during extracorporeal life support (ECLS) for cardiogenic shock may improve pulsatility and coronary perfusion, thereby promoting recovery of cardiac function. However, the risks and benefits of IABP during ECLS in real clinical settings have not been evaluated. This study aims to evaluate the effect of IABP ...
McCormick Liam M LM 1Department of Cardiovascular Medicine, University of Cambridge, United - - 2014
-The incretin hormone, glucagon-like peptide-1 (GLP-1), promotes myocardial glucose uptake and may improve myocardial tolerance to ischemia. Endogenous GLP-1 (7-36) is augmented by pharmacological inhibition of dipeptidyl peptidase-4 (DPP-4). We investigated whether chronic DPP-4 inhibition by sitagliptin protected against ischemic left ventricular (LV) dysfunction during dobutamine stress in patients with ...
Projahn Delia D Institute for Molecular Cardiovascular Research (IMCAR), Medical Faculty, RWTH Aachen University, Aachen, Germany; Institute for Cardiovascular Prevention (IPEK), University Hospital of the LMU Munich, Munich, - - 2014
Myocardial infarction (MI) induces a complex inflammatory immune response, followed by the remodelling of the heart muscle and scar formation. The rapid regeneration of the blood vessel network system by the attraction of hematopoietic stem cells is beneficial for heart function. Despite the important role of chemokines in these processes, ...
Stahelova Anna A Laboratory of Immunogenomics & Immunoproteomics, Department of Immunology, Faculty of Medicine & Dentistry, Palacky University Olomouc, I. P. Pavlova Str. 6, 775 20, Olomouc, Czech - - 2014
Recruitment of inflammatory cells to the arterial wall is an important pathogenic mechanism of atherosclerosis and coronary artery disease (CAD). Functional variability in the genes encoding for chemokines that promote infiltration of atherosclerotic plaques by macrophages and lymphocytes may therefore contribute to the genetic susceptibility to CAD. We, therefore, investigated ...
Thierfelder Kolja M KM From the *Institute of Clinical Radiology, Departments of †Neurology, and ‡Neuroradiology, and §Institute for Stroke and Dementia Research, Ludwig-Maximilians-University Hospital Munich, Munich, - - 2014
The aims of this study were to determine the diagnostic accuracy of whole-brain computed tomographic perfusion (WB-CTP) in small ischemic brain infarctions and to identify factors influencing the detection rate. Out of a retrospective cohort of 1380 subjects who underwent initial WB-CTP because of suspected stroke, we selected all patients ...
Iqbal Nayyar - - 2014
It is important to establish the cardiovascular (CV) safety profile of novel antidiabetic drugs. Pooled analyses were performed of 20 randomized controlled studies (N = 9156) of saxagliptin as monotherapy or add-on therapy in patients with type 2 diabetes mellitus (T2DM) as well as a subset of 11 saxagliptin + ...
Rose-Jones Lisa J - - 2014
Heart failure with preserved ejection fraction (HFpEF) is a complex clinical syndrome based on traditional heart failure symptoms with documentation of increased left ventricular filling pressures and preserved left ventricular ejection fraction. The exact mechanisms that induce HFpEF are not known. End-diastolic ventricular stiffness does not seem to be acting ...
Uppal Neha N Assistant Professor, Department of Biochemistry, Sri Guru Ram Das Institute of Medical Sciences and Research , Vallah, Amritsar, India - - 2014
Introduction: There is now a consensus that atherosclerosis represents a state of heightened oxidative stress which is characterized by lipid and protein oxidation in the vascular wall. Inspite of many efforts which were made to explain the role of oxidative stress in progression of CAD (Coronary Artery Disease), its predictive ...
Kim Eung Ju EJ 1Cardiovascular Center, Division of Cardiology, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, - - 2014
-Atherosclerosis is considered to be an inflammatory disease associated with the activation of hematopoietic and immune-related organs such as the bone marrow (BM) and spleen. We evaluated the metabolic activity of those organs and of the carotid artery with (18)F-FDG PET in patients with coronary artery disease, including acute myocardial ...
Chen I-Hsuan IH From the Division of Gerontology (I.H.C., V.N., B.M.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Institute for Aging Research (B.M.), Hebrew SeniorLife, Boston; Department of Physical Therapy and Assistive Technology (I.H.C.), National Yang-Ming University, Taipei; and the Center for Dynamical Biomarkers and Translational Medicine (I.H.C., V.N., B.M.), National Central University, Jhongli, - - 2014
Brain damage within the right middle cerebral artery (MCA) territory is particularly disruptive to mediolateral postural stabilization. The objective of this cross-sectional study was to test the hypothesis that chronic right MCA infarcts (as compared to left) are associated with slower and more bilaterally asymmetrical gait. We further hypothesized that ...
Pérennou Dominic A DA From the Institute of Rehabilitation (D.A.P.), University Hospital Grenoble; Laboratory TIMC-IMAG CNRS 5525 Team Motricity-Plasticity (D.A.P.), Grenoble-Alpes University, France; and International Centre for Allied Health Evidence (S.L.H.), School of Health Science, University of South Australia, - - 2014
Experimental(1) and clinical evidence support right hemisphere dominance for postural control, given its specialized role in constructing and updating spatial references.(2,3) As a prerequisite for walking, this right hemisphere dominance for postural control should also affect gait.(4) In this issue of Neurology®, Chen et al.(5) confirm this view and reveal ...
Brunetti Natale Daniele ND Cardiology Department, University of Foggia, Foggia, - - 2014
Acute coronary syndrome is characterized by an acute inflammatory systemic response. We investigated whether timely reperfusion could reduce the inflammatory response in patients with ST-elevation acute myocardial infarction (STEMI). Forty-seven consecutive patients with STEMI eligible for fibrinolysis and admitted to a coronary care unit were enrolled in the study and ...
Yetgin Tuncay T Department of Cardiology, Thoraxcentre, room Ee-2389a, Erasmus University Medical Center, Dr. Molewaterplein 50-60, 3015 GE, Rotterdam, The Netherlands, - - 2014
Interrupting myocardial reperfusion with intermittent episodes of ischemia (i.e., postconditioning) during primary percutaneous coronary intervention (PPCI) has been suggested to protect myocardium in ST-segment elevation myocardial infarction (STEMI). Nevertheless, trials provide inconsistent results and any advantage in long-term outcomes remains elusive. Using a retrospective study design, we evaluated the impact ...
Hausenloy Dj D The Hatter Cardiovascular Institute, University College London, , London, - - 2014
Cyclosporin-A (CsA) has been reported to reduce myocardial infarct size in both the experimental and clinical settings. This protective effect is dependent on its ability to prevent the opening of the mitochondrial permeability transition pore, a critical determinant of cell death in the setting of acute ischaemia-reperfusion injury. Whether CsA ...
Xu Xiaohan X Department of Cardiology, Beijing An Zhen Hospital, Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Disease, Anzhenli Avenue, Chao Yang District, Beijing, 100029, - - 2014
Trimetazidine has been shown to improve angina pectoris and left ventricular (LV) function in diabetic patients with ischaemic cardiomyopathy. The objective of this study was to evaluate the effects of trimetazidine on recurrent angina pectoris and LV structure after drug-eluting stent (DES) implantation in elderly multivessel coronary heart disease (CHD) ...
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