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Markowitz Steven M SM Division of Cardiology, Department of Medicine, Cornell University Medical Center, New York, - - 2014
Because of prognostic and therapeutic implications, the distinction between idiopathic right ventricular (RV) outflow tract (iRVOT) and arrhythmogenic RV cardiomyopathy (ARVC) is clinically important. Over the last 2 decades multiple reports have identified RV abnormalities using CMR in patients with idiopathic VT, suggesting a link between these arrhythmias and ARVC. ...
Zhao Jing-Jie JJ Clinical Molecular Biology Laboratory, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. - - 2014
The aim of the current study was to confirm the effect and elucidate the mechanism of bone marrow mesenchymal stem cells (BMSCs) in acute myocardial infarction (AMI). AMI was induced in mini‑swine by ligating the left anterior descending coronary artery, and BMSCs (1x107) were injected via a sterile microinjection into ...
Hu Xianwen X *Weil Institute of Critical Care Medicine, Rancho Mirage, California; †The Second Hospital of Anhui Medical University, Hefei, China; and ‡Keck School of Medicine of the University of Southern California, Los Angeles, - - 2014
Severe hemorrhagic shock and resuscitation is a state of global body ischemia and reperfusion that causes myocardial and cerebral dysfunction. We investigated whether remote ischemic preconditioning (RIPC) would reduce myocardial and cerebral ischemia and reperfusion injuries after hemorrhagic shock as the result of the KATP channel activation. Twenty-one male rats ...
Santos Angela B S AB Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA; Postgraduate Program in Cardiovascular Sciences, Cardiology, Federal University of Rio Grande do Sul, - - 2014
Left atrial (LA) enlargement is present in the majority of heart failure with preserved ejection fraction (HFpEF) patients and is a marker of risk. However, the importance of LA function in HFpEF is less well understood. The PARAMOUNT trial enrolled HFpEF patients (LVEF ≥45%, NT-proBNP >400 pg/mL). We assessed LA reservoir, ...
Trulock Kevin M KM Duke Center for Atrial Fibrillation, Duke University Medical Center, Durham, North - - 2014
Because nonpharmacological interventions likely alter the risks and benefits associated with rhythm control, this paper reviews the role of current rhythm control strategies in atrial fibrillation. This report also focuses on the specific limitations of pharmacological interventions and the utility of percutaneous ablation in this growing population of patients with ...
Gujral Gina G School of Pharmacy, The University of Queensland, Brisbane, QLD, Australia, - - 2014
Background Adherence to evidence based medicines in patients who have experienced a myocardial infarction remains low. Individual's beliefs towards their medicines are a strong predictor of adherence and may influence other factors that impact on adherence. Objective To investigate if community pharmacists discussing patients' beliefs about their medicines improved medication ...
Gyllenhammar Tom T Department of Clinical Physiology, Lund University, Lund University Hospital, Lund 221 85, - - 2014
To determine if myocardial perfusion (MP) during hyperaemia is decreased in young patients with hypertrophic cardiomyopathy (HCM). Also, to determine if an MP decrease is associated with diastolic dysfunction, and to investigate if young subjects at risk of HCM show differences in MP compared with controls. This study included 10 ...
Jurcut R R University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania, - - 2014
To describe morphological and functional cardiovascular changes in acromegaly (ACM) patients, as well as to investigate the ability of Doppler-based myocardial deformation imaging (DMI) to characterize subtle dysfunction in ACM. 69 patients (pts) with ACM (mean age 47 ± 10 years, 27 men) and 31 controls (mean age 43 ± 16 years, matched for age and ...
Mateos Alonso A Servicio de Urgencias Médicas de Madrid SUMMA112; Centro Nacional de Investigaciones Cardiovasculares CNIC, - - 2014
We seek to examine the efficacy and safety of prereperfusion emergency medical services (EMS)-administered intravenous metoprolol in anterior ST-segment elevation myocardial infarction patients undergoing eventual primary angioplasty. This is a prespecified subgroup analysis of the Effect of Metoprolol in Cardioprotection During an Acute Myocardial Infarction trial population, who all eventually ...
Senol Sefa S Department of Cardiovascular Surgery, Educational and Research Hospital, Elazig, Turkey - - 2014
This study compared plasminogen activator inhibitor 1 and methylenetetrahydrofolate reductase C677T and A1298C polymorphisms in patients with myocardial infarction with ST-segment elevation before undergoing to coronary artery bypass grafting, and in patients who had previously undergone coronary artery bypass grafting. Seventy patients with myocardial infarction with ST-segment elevation, scheduled to ...
El-Aziz Tarek A Abd TA Cardiology Department, Faculty of Medicine, Zagazig University, Zagazig, - - 2014
Endogenous fibrinolysis is a protective mechanism against arterial thrombotic occlusion, which would otherwise lead to permanent tissue damage as acute myocardial infarction (AMI). We aimed to investigate the association of plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (TPA) genes polymorphisms with myocardial infarction and its outcomes in Egyptian patients. ...
Zhang Hong-Ju HJ Department of Ultrasound, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167, Bei Lishi Road, Xicheng District, Beijing, 100037, People's Republic of - - 2014
We aimed to investigate whether left ventricular (LV) twist analysis can detect the extent of myocardial fibrosis in patients with hypertrophic cardiomyopathy (HCM). This prospective case-control study recruited 81 consecutive patients with HCM examined between January 2012 and April 2013. Data of 76 patients were analyzed after excluding 5 patients ...
Sadamatsu Kenji K Department of Cardiology, Saga-ken Medical Centre Koseikan, Saga, Japan. Electronic address: - - 2014
Beta-blockers are used to control the heart rate prior to coronary computed tomography (CT) angiography. However, in-hospital administration is time-consuming, and it is hard to decrease the heart rate to <60 beats per minute (bpm) when the initial heart rate is increased. In this study, we examined whether the single ...
Pucci S S Dept. Biomedicine and Prevention, Tor Vergata University of Rome, Italy. Electronic address: - - 2014
Acute myocardial infarction (AMI), is related to a diffuse active inflammation of the coronary tree associated with rupture of one of the multiple vulnerable plaques. The presence of soluble mediators of inflammation with their synergic or antagonistic actions coordinates the physiological response determining the plaque fate and the fatal event. ...
Chen Melissa - - 2014
BackgroundWe previously demonstrated that older beagles have impaired whole body and myocardial insulin responsiveness (MIR), and that glucagon-like peptide-1 (GLP-1 [7¿36] amide) improves MIR in young beagles with dilated cardiomyopathy (DCM). Here, we sought to determine if aging alone predisposes to an accelerated course of DCM, and if GLP-1 [7¿36] ...
Santoso Teguh T Department of Internal Medicine, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, - - 2014
Prior studies suggest that endomyocardial implantation of autologous bone marrow (BM) mononuclear cell therapy improves symptoms and left ventricular (LV) function in patients with refractory angina; however, the therapeutic efficacy in patients with ischemic cardiomyopathy is unclear. In a randomized, double-blind, placebo-controlled trial, 28 patients with advanced ischemic cardiomyopathy [New ...
Soslow Jonathan H JH Division of Pediatric Cardiology, Department of Pediatrics, Vanderbilt University Medical Center, 2200 Children's Way, Suite 5230 DOT, Nashville, TN, 37232, USA, - - 2014
The objective of the study was to perform a retrospective pilot study to evaluate the potential of myocardial T1 in assessment of Duchenne muscular dystrophy (DMD) cardiomyopathy. Early identification of DMD cardiac disease, particularly myocardial fibrosis, would allow earlier therapy, potentially improving outcomes. Shortened myocardial T1 measured by cardiac MRI ...
Cakal Sinem S Department of Cardiology, Kartal Kosuyolu Yuksek Ihtisas Heart and Research Hospital, Istanbul, - - 2014
Atrial septal defect (ASD) causes chronic volume overload of the right heart. The potential adverse effects of this long-standing volume overload to left atrium (LA) and left ventricle (LV) and their response to ASD closure has been poorly studied. We studied 20 ASD patients before the procedure, at the 24-hour ...
Ankam Jyoti J Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, Maryland, - - 2014
Following a myocardial infarction, lipid-lowering therapy is an established intervention to reduce the risk of recurrent cardiovascular events. Prior studies show a need to improve clinical practice in this area. Here, we review the latest research and perspectives on improving postmyocardial infarction lipid control. Dyslipidemia and myocardial infarction remain leading ...
De Vecchis R R Cardiology Unit, Presidio Sanitario Intermedio''Elena d'Aosta'', Napoli, Italy - - - 2014
The present meta--analysis attempted to assess whether an unfavourable cardiovascular risk profile could be identified in the case of two COX2 selective inhibitors (COXIBs), namely celecoxib and etoricoxib. Based on the data from the literature, our meta--analysis aimed to assess the probability of major cardiovascular events reported with the use ...
Webster I I University of Stellenbosch, Cape Town, South Africa, - - 2014
In isolated rat heart perfusion experiments, drug administration occurs via retrograde perfusion. This can be done in the non-recirculating mode (coronary effluent is discarded), or recirculating mode (coronary effluent is collected and reused). It was recently observed in our lab while using sanguinarine, an MKP-1 inhibitor, that there were differences ...
Clemmensen Tor Skibsted TS Department of Cardiology, Aarhus University Hospital, Skejby, Denmark. Electronic address: - - 2014
Coronary allograft vasculopathy (CAV) in heart transplant (HTx) recipients is characterized by diffuse affection of epicardial and intramyocardial coronary vessels. Despite significant CAV and anticipated affected myocardial function, left ventricular ejection fraction (LVEF) is often within the normal range, indicating the need of more sophisticated non-invasive methods to detect impaired ...
Forteza Mj M University of Valencia, University Clinic Hospital, INCLIVA, Valencia, - - 2014
In the context of myocardial infarction (MI) the availability of metabolites is clearly restricted, therefore a fuel metabolic shifts takes place. Previous studies have indicated that peroxisome proliferator activated receptor co-activator alpha (PGC-1α) pathway is a crucial regulator of cardiac metabolism in response to cardiac stress. Here we address the ...
Ilter A A Department of Cardiology, Kanuni Training and Research Hospital, Trabzon, Turkey, - - 2014
The aim of this study was to evaluate atrial electromechanical delay (EMD), P wave dispersion (Pwd), and left atrial (LA) mechanical functions in patients with active acromegaly. Twenty-three patients with active acromegaly and 27 age- and sex-matched controls were included in this study. All atrial electromechanical interval parameters (PA lateral, ...
Matsa Lova Satyanarayna LS Department of Genetics, Osmania University, Hyderabad, AP, - - 2014
Dilated cardiomyopathy (DCM) is a myocardial disease of unknown etiology with left ventricular dilatation and impaired myocardial contractility leading to heart failure. It is considered to be a multifactorial disorder with the interplay of both genetic and environmental factors. One of the possible genes implicated in DCM is endothelin 1 ...
De Dios E E Hospital Clinico Universitario, INCLIVA, Valencia, - - 2014
Using cardiac imaging techniques it has been demonstrated that, after successful coronary revascularization of acute myocardial infarction (MI), microvascular obstruction (MVO) resolves spontaneously. Data on the course of this process in "in vivo" models are scarce. We aimed to characterize the dynamics of MVO in a swine model of reperfused ...
Puntmann Valentina O VO From the Department of Cardiovascular Imaging, Division of Imaging Sciences and Biomedical Engineering (V.O.P., E.A.U., R.H.B., N.B.N., Y.-S.K., D.D., A.M., C.C., S.P., G.C.-W., E.N.), Department of Biomedical Engineering, Division of Imaging Sciences and Biomedical Engineering (N.G.), and Cardiovascular Division (P.C.), King's College London, United Kingdom; Department of Radiology, University of Bonn, Germany (D.D.); Philips Healthcare, United Kingdom (D.M.H.); and University of Leeds, United Kingdom (S.P.). - - 2014
Increased aortic stiffness is related to increased ventricular stiffness and remodeling. Myocardial fibrosis is the pathophysiological hallmark of failing heart. We investigated the relationship between noninvasive imaging markers of myocardial fibrosis, native T1, and late gadolinium enhancement, respectively, and aortic stiffness in ventricular remodeling. Consecutive patients with known dilated cardiomyopathy ...
Imai Masamichi M From the Division of Cardiology, Department of Medicine, Johns Hopkins University, 600 N Wolfe St, Blalock 524, Baltimore, MD 21287-0409 (M.I., B.A.V., S.S., S.D., A.C.A., J.A.C.L.); Department of Cardiology, Johns Hopkins Hospital, Baltimore, Md (M.H.); Cardiovascular Health Research Unit, Washington University, St Louis, Mo (S.R.H.); and Office of Biostatistics Research, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Md (C.O.W., - - 2014
Purpose To investigate the association between left atrial (LA) function and left ventricular myocardial fibrosis using cardiac magnetic resonance (MR) imaging in a multi-ethnic population. Materials and Methods For this HIPAA-compliant study, the institutional review board at each participating center approved the study protocol, and all participants provided informed consent. ...
Mehta Puja K PK Barbra Streisand Women's Heart Center, Cedars-Sinai Heart Institute, Los Angeles, CA, United - - 2014
Heart rate variability (HRV) is reduced in stable ischemic heart disease (SIHD) patients and is associated with sudden cardiac death (SCD). We evaluated the impact of traditional acupuncture (TA) on cardiac autonomic function measured by HRV in SIHD patients. We conducted a randomized controlled study of TA, sham acupuncture (SA), ...
Gregory Shaun D SD School of Medicine, University of Queensland, Brisbane, Queensland, Australia; Innovative Cardiovascular Engineering and Technology Laboratory, The Prince Charles Hospital, Brisbane, Queensland, Australia; Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, - - 2014
Biventricular support with dual rotary ventricular assist devices (VADs) has been implemented clinically with restriction of the right VAD (RVAD) outflow cannula to artificially increase afterload and, therefore, operate within recommended design speed ranges. However, the low preload and high afterload sensitivity of these devices increase the susceptibility of suction ...
Brauer Ruth R Department of Non-Communicable Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK - - 2014
Antipsychotics increase the risk of stroke. Their effect on myocardial infarction remains uncertain because people prescribed and not prescribed antipsychotic drugs differ in their underlying vascular risk making between-person comparisons difficult to interpret. The aim of our study was to investigate this association using the self-controlled case series design that ...
Halladin Natalie L NL Department of Surgery, Herlev Hospital, University of Copenhagen, Herlev, Denmark - - 2014
Aim: To test whether melatonin reduces oxidative and inflammatory biomarkers in a closed-chest porcine model of acute myocardial infarction. Materials and Methods: Twenty pigs were randomized to receive a total dosage of 200 mg (0.4 mg/ml) of melatonin, or placebo immediately prior to reperfusion of a coronary artery balloon occlusion ...
Tendera Michal M Medical University of Silesia, Katowice, - - 2014
To use CLARIFY, a prospective registry of patients with stable CAD (45 countries), to explore heart rate (HR) control and beta-blocker use. We analyzed the CLARIFY population according to beta-blocker use via descriptive statistics with Pearson's χ(2) test for comparisons, as well as a multivariable stepwise model. Data on beta-blocker ...
Sheriff Ahmed A Department of Nephrology and Internal Intensive Care Medicine, Charité - Universitätsmedizin Berlin, Berlin, - - 2014
Background: There is substantial evidence that C-reactive protein (CRP) mediates secondary damage of the myocardium after acute myocardial infarction (AMI). The aim of this animal trial in pigs was to specifically deplete CRP from porcine plasma after AMI and to study possible beneficial effects of the reduced CRP concentration on ...
Vriesendorp Pieter A PA Department of Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, the - - 2014
Adverse left ventricular (LV) remodeling predicts heart failure symptoms and overt LV dysfunction in patients with hypertrophic cardiomyopathy (HCM), but its influence on the occurrence of sudden cardiac death (SCD) is unknown. The aim of this study was to investigate the effect of adverse LV remodeling on SCD risk in ...
Toldo Stefano S *Virginia Commonwealth University Pauley Heart Center, Virginia Commonwealth University, Richmond, VA; †Victoria Johnson Research Laboratories, Virginia Commonwealth University, Richmond, VA; and ‡Department of Pharmacotherapy and Outcome Studies, Virginia Commonwealth University, Richmond, - - 2014
Interleukin-1β (IL-1β) modulates the inflammatory response during acute myocardial infarction (AMI) and progression to ischemic cardiomyopathy. We investigated whether blockade of IL-1β after the onset of the cardiac dysfunction prevented left ventricular (LV) adverse remodeling in a mouse model of anterior nonreperfused AMI. Infarct size and LV systolic function were ...
Miao Qingfeng Q National Heart Research Institute Singapore, National Heart Centre Singapore, - - 2014
We investigated global and regional effects of myocardial transplantation of human induced pluripotent stem cell (iPSC)-derived mesenchymal stem cells (iMSCs) in infarcted myocardium. Acute myocardial infarction (MI) was induced by ligation of left coronary artery of severe combined immunodeficient mice before 2 × 10(5) iMSCs or cell-free saline were injected ...
Delgado Betancourt V V Functional Genomics Institute (IGF), Physiology, Montpellier, - - 2014
Acute myocardial infarction (AMI) is the major cause of cardiovascular mortality worldwide. Early reperfusion is the only treatment recommended to reduce infarct size (IS). However, reperfusion presents also deleterious effects such as ischemia-reperfusion (IR) injury due to irreversible apoptotic death of cardiomyocytes. Most ischemic episodes are triggered by an increase ...
Yontar O C OC Bursa Postgraduate Hospital, Cardiology, Bursa, - - 2014
Atrioventricular nodal reentry tachycardia (AVNRT) is known to be associated with increased risk of susceptibility for ventricular arrhythmias and sudden death. Studies indicate that prolongation of the interval between the peak and end of the T wave (Tpeak to Tend, Tp-e) on the 12-lead ECG, is a marker of ventricular ...
Sagach Vf V Bogomoletz Institute of Physiology, Circulation, Kiev, - - 2014
Hydrogen sulfide is enzymaticaly synthesized by three enzymes - cystathionine gama-lyase (CSE), cystathionine beta-lyase (CBS) and 3-mercaptopyruvate sulfurtransferase (3-MST). After physical training of rats (4 weeks swimming course) we observed in myocardium the increased of these enzymes expression (in 1,5; 2,5 and 5 times accordingly), which accompanied with increased H2S ...
Forteza Mj M University of Valencia, University Clinic Hospital, INCLIVA, Valencia, - - 2014
Programmed death-1 (PD-1) and Programmed death-1 ligand (PD-L1) regulate immune response. Previous studies associate an immune deregulation in ST-elevation myocardial infarction STEMI. We recruited 100 patients with a first STEMI treated with reperfusion. In all patients PD-1 and PD-L1 expression was studied 24 h post-reperfusion in peripheral blood mononuclear cells ...
Malik A A Hatter Cardiovascular Institute, London, United - - 2014
Whether, stromal cell-derived factor 1 αlpha (SDF-1α) can protect human heart tissue is not known, and is investigated here using isolated human atrial trabeculae exposed to simulated ischaemia-reperfusion injury (IRI). Atrial trabeculae were isolated from right atrial appendage tissue harvested from consented patients undergoing elective cardiac bypass surgery (REC 00/0275). They ...
Andrade-Castellanos Carlos A CA Department of Internal Medicine, Hospital Civil de Guadalajara "Dr. Juan I. Menchaca", Salvador Quevedo y Zubieta No. 750, Guadalajara, Jalisco, Mexico, - - 2014
Non-ST elevation acute coronary syndromes (NSTEACS) represent a spectrum of disease including unstable angina and non-ST segment myocardial infarction (NSTEMI). Despite treatment with aspirin, beta-blockers and nitroglycerin, unstable angina/NSTEMI is still associated with significant morbidity and mortality. Although evidence suggests that low molecular weight heparin (LMWH) is more efficacious compared ...
Karaagac K K Bursa Postgraduate Hospital, Cardiology, Bursa, - - 2014
Coronary artery ectasia (CAE) is commonly defined as local or generalized dilatation of a coronary vessel up to 1,5 times the diameter of an adjacent vessel. Tp-Te interval and Tp-Te/QT ratio have emerged as a novel electrocardiographic (ECG) markers of increased dispersion of ventricular repolarization. The aim of this study ...
Lopez Salazar B B CIMA, University of Navarra, Division of Cardiovascular Sciences, Pamplona, - - 2014
It has been proposed that galectin-3 (Gal-3) may be a pathogenic factor and a biomarker of myocardial fibrosis in patients with heart failure (HF). The aim of this study was to analyze whether Gal-3 is associated with myocardial fibrosis in patients with chronic stable HF. Endomyocardial biopsies and blood samples ...
Gomaa Ibrahim W W Cardiology department - faculty of medicine, Ain shams university, Cairo, - - 2014
Tissue Doppler imaging (TDI) has provided an objective means to quantify global and regional ventricular functions with improved accuracy and greater reproducibility than conventional echocardiography. This study was conducted to assess right ventricular (RV) myocardial systolic activation by TDI in children with pulmonary arterial hypertension (PAH). Forty pediatric patients with ...
Werner I I JW Goethe University, Thoracic and Cardiovascular Surgery, Frankfurt am Main, - - 2014
Human Relaxin-2 is best known for its physiological role during pregnancy in the growth and differentiation of the reproductive tract as well as in the renal and systemic hemodynamic changes. This factor can also be involved in the pathophysiology of arterial hypertension and heart failure. Within the last years, Relaxin-2 ...
Harbar M O MO Lviv medical university, Lviv, - - 2014
Endothelin-1 (E-1) is the most informative marker of inflammation of the vessel wall. It causes the expression of adhesion molecules that stimulate the migration of leukocytes to the subendothelium. Ratio apoB/apoA1 reflects balance of cholesterol transport. Increased apoB/apoA1 indicates the deposition of cholesterol in the vessel wall and the progression ...
Chen Junyu J Department of Cardiology, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, Guangdong, People's Republic of - - 2014
Cardiac resynchronization therapy can treat chronic heart failure through either biventricular pacing (BVP) or isolated left ventricular pacing (LVP), and the efficacy is depended on QRS duration. However, the optimal therapeutic choice of pacing or how the QRS influences the efficacy remains uncertain. To investigate this uncertainty, we searched available ...
Huynh William W Prince of Wales Clinical School, University of New South Wales, Sydney, NSW, Australia, - - 2014
The cerebellum has a vital role in fine motor control of the limbs. Consequently, downstream changes in peripheral axonal function may develop following a cerebellar infarct, in part, to adapt to the resultant impairment. The present study investigated changes in excitability in ipsilateral and contralateral upper limb peripheral motor axons ...
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