Search Results
Results 1 - 50 of 1309
1 2 3 4 5 6 7 8 9 10 >
Zhao Jing-Jie JJ Clinical Molecular Biology Laboratory, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. - - 2014
The aim of the current study was to confirm the effect and elucidate the mechanism of bone marrow mesenchymal stem cells (BMSCs) in acute myocardial infarction (AMI). AMI was induced in mini‑swine by ligating the left anterior descending coronary artery, and BMSCs (1x107) were injected via a sterile microinjection into ...
Cakal Sinem S Department of Cardiology, Kartal Kosuyolu Yuksek Ihtisas Heart and Research Hospital, Istanbul, - - 2014
Atrial septal defect (ASD) causes chronic volume overload of the right heart. The potential adverse effects of this long-standing volume overload to left atrium (LA) and left ventricle (LV) and their response to ASD closure has been poorly studied. We studied 20 ASD patients before the procedure, at the 24-hour ...
Ankam Jyoti J Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, Maryland, - - 2014
Following a myocardial infarction, lipid-lowering therapy is an established intervention to reduce the risk of recurrent cardiovascular events. Prior studies show a need to improve clinical practice in this area. Here, we review the latest research and perspectives on improving postmyocardial infarction lipid control. Dyslipidemia and myocardial infarction remain leading ...
Webster I I University of Stellenbosch, Cape Town, South Africa, - - 2014
In isolated rat heart perfusion experiments, drug administration occurs via retrograde perfusion. This can be done in the non-recirculating mode (coronary effluent is discarded), or recirculating mode (coronary effluent is collected and reused). It was recently observed in our lab while using sanguinarine, an MKP-1 inhibitor, that there were differences ...
De Vecchis R R Cardiology Unit, Presidio Sanitario Intermedio''Elena d'Aosta'', Napoli, Italy - - - 2014
The present meta--analysis attempted to assess whether an unfavourable cardiovascular risk profile could be identified in the case of two COX2 selective inhibitors (COXIBs), namely celecoxib and etoricoxib. Based on the data from the literature, our meta--analysis aimed to assess the probability of major cardiovascular events reported with the use ...
De Dios E E Hospital Clinico Universitario, INCLIVA, Valencia, - - 2014
Using cardiac imaging techniques it has been demonstrated that, after successful coronary revascularization of acute myocardial infarction (MI), microvascular obstruction (MVO) resolves spontaneously. Data on the course of this process in "in vivo" models are scarce. We aimed to characterize the dynamics of MVO in a swine model of reperfused ...
Forteza Mj M University of Valencia, University Clinic Hospital, INCLIVA, Valencia, - - 2014
In the context of myocardial infarction (MI) the availability of metabolites is clearly restricted, therefore a fuel metabolic shifts takes place. Previous studies have indicated that peroxisome proliferator activated receptor co-activator alpha (PGC-1α) pathway is a crucial regulator of cardiac metabolism in response to cardiac stress. Here we address the ...
Ilter A A Department of Cardiology, Kanuni Training and Research Hospital, Trabzon, Turkey, - - 2014
The aim of this study was to evaluate atrial electromechanical delay (EMD), P wave dispersion (Pwd), and left atrial (LA) mechanical functions in patients with active acromegaly. Twenty-three patients with active acromegaly and 27 age- and sex-matched controls were included in this study. All atrial electromechanical interval parameters (PA lateral, ...
Matsa Lova Satyanarayna LS Department of Genetics, Osmania University, Hyderabad, AP, - - 2014
Dilated cardiomyopathy (DCM) is a myocardial disease of unknown etiology with left ventricular dilatation and impaired myocardial contractility leading to heart failure. It is considered to be a multifactorial disorder with the interplay of both genetic and environmental factors. One of the possible genes implicated in DCM is endothelin 1 ...
Imai Masamichi M From the Division of Cardiology, Department of Medicine, Johns Hopkins University, 600 N Wolfe St, Blalock 524, Baltimore, MD 21287-0409 (M.I., B.A.V., S.S., S.D., A.C.A., J.A.C.L.); Department of Cardiology, Johns Hopkins Hospital, Baltimore, Md (M.H.); Cardiovascular Health Research Unit, Washington University, St Louis, Mo (S.R.H.); and Office of Biostatistics Research, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Md (C.O.W., - - 2014
Purpose To investigate the association between left atrial (LA) function and left ventricular myocardial fibrosis using cardiac magnetic resonance (MR) imaging in a multi-ethnic population. Materials and Methods For this HIPAA-compliant study, the institutional review board at each participating center approved the study protocol, and all participants provided informed consent. ...
Puntmann Valentina O VO From the Department of Cardiovascular Imaging, Division of Imaging Sciences and Biomedical Engineering (V.O.P., E.A.U., R.H.B., N.B.N., Y.-S.K., D.D., A.M., C.C., S.P., G.C.-W., E.N.), Department of Biomedical Engineering, Division of Imaging Sciences and Biomedical Engineering (N.G.), and Cardiovascular Division (P.C.), King's College London, United Kingdom; Department of Radiology, University of Bonn, Germany (D.D.); Philips Healthcare, United Kingdom (D.M.H.); and University of Leeds, United Kingdom (S.P.). - - 2014
Increased aortic stiffness is related to increased ventricular stiffness and remodeling. Myocardial fibrosis is the pathophysiological hallmark of failing heart. We investigated the relationship between noninvasive imaging markers of myocardial fibrosis, native T1, and late gadolinium enhancement, respectively, and aortic stiffness in ventricular remodeling. Consecutive patients with known dilated cardiomyopathy ...
Gregory Shaun D SD School of Medicine, University of Queensland, Brisbane, Queensland, Australia; Innovative Cardiovascular Engineering and Technology Laboratory, The Prince Charles Hospital, Brisbane, Queensland, Australia; Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, - - 2014
Biventricular support with dual rotary ventricular assist devices (VADs) has been implemented clinically with restriction of the right VAD (RVAD) outflow cannula to artificially increase afterload and, therefore, operate within recommended design speed ranges. However, the low preload and high afterload sensitivity of these devices increase the susceptibility of suction ...
Halladin Natalie L NL Department of Surgery, Herlev Hospital, University of Copenhagen, Herlev, Denmark - - 2014
Aim: To test whether melatonin reduces oxidative and inflammatory biomarkers in a closed-chest porcine model of acute myocardial infarction. Materials and Methods: Twenty pigs were randomized to receive a total dosage of 200 mg (0.4 mg/ml) of melatonin, or placebo immediately prior to reperfusion of a coronary artery balloon occlusion ...
Brauer Ruth R Department of Non-Communicable Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK - - 2014
Antipsychotics increase the risk of stroke. Their effect on myocardial infarction remains uncertain because people prescribed and not prescribed antipsychotic drugs differ in their underlying vascular risk making between-person comparisons difficult to interpret. The aim of our study was to investigate this association using the self-controlled case series design that ...
Sheriff Ahmed A Department of Nephrology and Internal Intensive Care Medicine, Charité - Universitätsmedizin Berlin, Berlin, - - 2014
Background: There is substantial evidence that C-reactive protein (CRP) mediates secondary damage of the myocardium after acute myocardial infarction (AMI). The aim of this animal trial in pigs was to specifically deplete CRP from porcine plasma after AMI and to study possible beneficial effects of the reduced CRP concentration on ...
Tendera Michal M Medical University of Silesia, Katowice, - - 2014
To use CLARIFY, a prospective registry of patients with stable CAD (45 countries), to explore heart rate (HR) control and beta-blocker use. We analyzed the CLARIFY population according to beta-blocker use via descriptive statistics with Pearson's χ(2) test for comparisons, as well as a multivariable stepwise model. Data on beta-blocker ...
Vriesendorp Pieter A PA Department of Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, the - - 2014
Adverse left ventricular (LV) remodeling predicts heart failure symptoms and overt LV dysfunction in patients with hypertrophic cardiomyopathy (HCM), but its influence on the occurrence of sudden cardiac death (SCD) is unknown. The aim of this study was to investigate the effect of adverse LV remodeling on SCD risk in ...
Toldo Stefano S *Virginia Commonwealth University Pauley Heart Center, Virginia Commonwealth University, Richmond, VA; †Victoria Johnson Research Laboratories, Virginia Commonwealth University, Richmond, VA; and ‡Department of Pharmacotherapy and Outcome Studies, Virginia Commonwealth University, Richmond, - - 2014
Interleukin-1β (IL-1β) modulates the inflammatory response during acute myocardial infarction (AMI) and progression to ischemic cardiomyopathy. We investigated whether blockade of IL-1β after the onset of the cardiac dysfunction prevented left ventricular (LV) adverse remodeling in a mouse model of anterior nonreperfused AMI. Infarct size and LV systolic function were ...
Miao Qingfeng Q National Heart Research Institute Singapore, National Heart Centre Singapore, - - 2014
We investigated global and regional effects of myocardial transplantation of human induced pluripotent stem cell (iPSC)-derived mesenchymal stem cells (iMSCs) in infarcted myocardium. Acute myocardial infarction (MI) was induced by ligation of left coronary artery of severe combined immunodeficient mice before 2 × 10(5) iMSCs or cell-free saline were injected into peri-infarcted ...
Andrade-Castellanos Carlos A CA Department of Internal Medicine, Hospital Civil de Guadalajara "Dr. Juan I. Menchaca", Salvador Quevedo y Zubieta No. 750, Guadalajara, Jalisco, Mexico, - - 2014
Non-ST elevation acute coronary syndromes (NSTEACS) represent a spectrum of disease including unstable angina and non-ST segment myocardial infarction (NSTEMI). Despite treatment with aspirin, beta-blockers and nitroglycerin, unstable angina/NSTEMI is still associated with significant morbidity and mortality. Although evidence suggests that low molecular weight heparin (LMWH) is more efficacious compared ...
Harbar M O MO Lviv medical university, Lviv, - - 2014
Endothelin-1 (E-1) is the most informative marker of inflammation of the vessel wall. It causes the expression of adhesion molecules that stimulate the migration of leukocytes to the subendothelium. Ratio apoB/apoA1 reflects balance of cholesterol transport. Increased apoB/apoA1 indicates the deposition of cholesterol in the vessel wall and the progression ...
Gomaa Ibrahim W W Cardiology department - faculty of medicine, Ain shams university, Cairo, - - 2014
Tissue Doppler imaging (TDI) has provided an objective means to quantify global and regional ventricular functions with improved accuracy and greater reproducibility than conventional echocardiography. This study was conducted to assess right ventricular (RV) myocardial systolic activation by TDI in children with pulmonary arterial hypertension (PAH). Forty pediatric patients with ...
Forteza Mj M University of Valencia, University Clinic Hospital, INCLIVA, Valencia, - - 2014
Programmed death-1 (PD-1) and Programmed death-1 ligand (PD-L1) regulate immune response. Previous studies associate an immune deregulation in ST-elevation myocardial infarction STEMI. We recruited 100 patients with a first STEMI treated with reperfusion. In all patients PD-1 and PD-L1 expression was studied 24 h post-reperfusion in peripheral blood mononuclear cells ...
Delgado Betancourt V V Functional Genomics Institute (IGF), Physiology, Montpellier, - - 2014
Acute myocardial infarction (AMI) is the major cause of cardiovascular mortality worldwide. Early reperfusion is the only treatment recommended to reduce infarct size (IS). However, reperfusion presents also deleterious effects such as ischemia-reperfusion (IR) injury due to irreversible apoptotic death of cardiomyocytes. Most ischemic episodes are triggered by an increase ...
Werner I I JW Goethe University, Thoracic and Cardiovascular Surgery, Frankfurt am Main, - - 2014
Human Relaxin-2 is best known for its physiological role during pregnancy in the growth and differentiation of the reproductive tract as well as in the renal and systemic hemodynamic changes. This factor can also be involved in the pathophysiology of arterial hypertension and heart failure. Within the last years, Relaxin-2 ...
Yontar O C OC Bursa Postgraduate Hospital, Cardiology, Bursa, - - 2014
Atrioventricular nodal reentry tachycardia (AVNRT) is known to be associated with increased risk of susceptibility for ventricular arrhythmias and sudden death. Studies indicate that prolongation of the interval between the peak and end of the T wave (Tpeak to Tend, Tp-e) on the 12-lead ECG, is a marker of ventricular ...
Karaagac K K Bursa Postgraduate Hospital, Cardiology, Bursa, - - 2014
Coronary artery ectasia (CAE) is commonly defined as local or generalized dilatation of a coronary vessel up to 1,5 times the diameter of an adjacent vessel. Tp-Te interval and Tp-Te/QT ratio have emerged as a novel electrocardiographic (ECG) markers of increased dispersion of ventricular repolarization. The aim of this study ...
Lopez Salazar B B CIMA, University of Navarra, Division of Cardiovascular Sciences, Pamplona, - - 2014
It has been proposed that galectin-3 (Gal-3) may be a pathogenic factor and a biomarker of myocardial fibrosis in patients with heart failure (HF). The aim of this study was to analyze whether Gal-3 is associated with myocardial fibrosis in patients with chronic stable HF. Endomyocardial biopsies and blood samples ...
Malik A A Hatter Cardiovascular Institute, London, United - - 2014
Whether, stromal cell-derived factor 1 αlpha (SDF-1α) can protect human heart tissue is not known, and is investigated here using isolated human atrial trabeculae exposed to simulated ischaemia-reperfusion injury (IRI). Atrial trabeculae were isolated from right atrial appendage tissue harvested from consented patients undergoing elective cardiac bypass surgery (REC 00/0275). They ...
Sagach Vf V Bogomoletz Institute of Physiology, Circulation, Kiev, - - 2014
Hydrogen sulfide is enzymaticaly synthesized by three enzymes - cystathionine gama-lyase (CSE), cystathionine beta-lyase (CBS) and 3-mercaptopyruvate sulfurtransferase (3-MST). After physical training of rats (4 weeks swimming course) we observed in myocardium the increased of these enzymes expression (in 1,5; 2,5 and 5 times accordingly), which accompanied with increased H2S ...
Chen Junyu J Department of Cardiology, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, Guangdong, People's Republic of - - 2014
Cardiac resynchronization therapy can treat chronic heart failure through either biventricular pacing (BVP) or isolated left ventricular pacing (LVP), and the efficacy is depended on QRS duration. However, the optimal therapeutic choice of pacing or how the QRS influences the efficacy remains uncertain. To investigate this uncertainty, we searched available ...
Huynh William W Prince of Wales Clinical School, University of New South Wales, Sydney, NSW, Australia, - - 2014
The cerebellum has a vital role in fine motor control of the limbs. Consequently, downstream changes in peripheral axonal function may develop following a cerebellar infarct, in part, to adapt to the resultant impairment. The present study investigated changes in excitability in ipsilateral and contralateral upper limb peripheral motor axons ...
Martinez C - - 2014
It was the aim of this study to determine prognosis of incidentally detected ambulatory atrial fibrillation (IA-AF) and its response to antithrombotic therapy. We performed a cohort study of 5,555 patients with IA-AF (mean age 70.9 ± 10.1, 38.4% female) and 24,705 age- and gender-matched controls without AF followed three ...
Lipkova Jolana J Faculty of Medicine, Institute of Pathological Physiology, Masaryk University, Kamenice 753/5, 625 00, Brno, Czech - - 2014
Chemokines, including RANTES, play a crucial role in the processes of inflammation during cardiovascular disorders, including myocardial infarction, disease progression and complications. This study aimed to evaluate the role of RANTES -403G/A polymorphism and levels in circulation in processes of development and progression of myocardial infarction and cardiogenic shock. A ...
Gazi Emine E Department of Cardiology, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, - - 2014
Objective: To investigate intercellular adhesion molecule-1 (ICAM1) and angiotensinogen (AGT) gene polymorphisms, as related to atherosclerosis and endothelial dysfunction, in coronary slow flow (CSF). Subjects and Methods: The participants in this study were 48 patients with CSF and 67 patients with normal coronary flow as controls. The K469E polymorphism of ...
Deng Yan Y Department of Ultrasound, The First Affiliated Hospital of Guangxi Medical University, Nanning, - - 2014
This study evaluated the feasibility of assessing left atrium (LA) function and asynchrony in patients with rheumatic mitral stenosis (MS) before and immediately after percutaneous balloon mitral valvuloplasty (PBMV) by real time three-dimensional echocardiography (RT3DE). Thirty patients with rheumatic MS who underwent PBMV and 30 controls were enrolled. RT3DE was ...
Hwang Hyosook H From the Department of Nuclear Medicine, Molecular Imaging and Therapeutic Medicine Research Center, Cyclotron Research Center, Institute for Medical Sciences, and Biomedical Research Institute, Chonbuk National University Medical School and Hospital, 634-18 GeumAm-dong Duckjin-gu Jeonju-si, Jeollabuk-do 561-803, South Korea (H.H., J.K., P.S.O., T.K.L., K.S.N., H.S.J., S.T.L., M.H.S., H.J.J.); and Department of Biomedical Engineering, Chonnam National University, Yeosu, South Korea - - 2014
Purpose To determine whether chitosan hydrogel nanoparticles loaded with vascular endothelial growth factor (VEGF) peptides (81-91 fragments) capable of targeting the ischemic myocardium enhance angiogenesis and promote therapeutic effects and whether radionuclide image-guided dosage control is feasible. Materials and Methods Experimental procedures and protocols were approved by the Institutional Animal ...
Liu Xiao-Yan XY aCenter for Arrhythmia Diagnosis and Treatment, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China bSchool of Biomedical Sciences, Charles Sturt University, Wagga Wagga, New South Wales, - - 2014
The variation of the substrates of verapamil-sensitive idiopathic left ventricular tachycardia (ILVT) was not understood. The purpose of this study was to investigate the variation of electroanatomic substrate [slow conduction zone (SCZ) and left ventricular conduction system (LVCS)] in ILVT and control individuals and markers of successful ablation. Electroanatomical mapping ...
Agati L L Department of Cardiology, 'Sapienza' University, Viale del Policlinico 155, Roma 00161, Italy - - 2014
Left ventricular (LV) diastolic filling is characterized by the formation of a vortex that supports an efficient transit into systolic ejection. Aim of this study was to assess the intraventricular (IV) blood flow dynamics among patients with ST elevated myocardial infarction (STEMI) at different degrees of LV dysfunction, in the ...
Patel Neil N Sullivan University College of Pharmacy , Louisville, KY , USA - - 2014
Abstract Background: Increased NF-κB levels play a crucial role in the pathophysiology of heart failure and are known to cause ventricular remodeling. Antisense therapy can be used for blocking the expression of NF-κB and subsequently avoiding heart failure. However, as with most biotechnology products, molecular instability and overall cost are ...
Graça Bruno B 1 Faculty of Medicine, University of Coimbra, Azinhaga de Santa Comba, 3000-548, Coimbra, - - 2014
OBJECTIVE. The purpose of this study was to compare cardiac MRI-derived parameters of left ventricular (LV) diastolic function between uncomplicated type 2 diabetes mellitus (DM2) and normoglycemic control subjects and to evaluate whether these parameters of LV diastolic function are related to coronary atherosclerosis. SUBJECTS AND METHODS. We prospectively studied ...
Llewellyn Michael E ME Departments of Radiology (M.E.L., R.B.J., E.W.O.) and Pathology (M.A.D.), Stanford University School of Medicine, Stanford, California USA; and Radiology Service, Veterans Affairs Palo Alto Health Care System, Palo Alto, California USA - - 2014
To evaluate the frequency of the "bright band sign" in patients with splenic infarcts as well as control patients and to thereby assess whether the bright band sign has potential utility as a sonographic sign of splenic infarction. Using an electronic search engine and image review, 37 patients were retrospectively ...
Schneider Heiko H University of - - 2014
Adults with Tetralogy of Fallot (ToF) have an increased risk of heart failure, arrhythmias and sudden death. We sought to investigate whether myocardial remodelling of the right ventricular outflow tract (RVOT) could be responsible. We collected RVOT myocardial biopsies from 10 ToF patients (6 male) at the time of pulmonary ...
Liu Liwen L Department of Ultrasound, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. - - 2014
The early detection of abnormal left ventricular systolic functions in patients with hypertrophic cardiomyopathy (HCM) remains a challenge. The aim of this study was to identify a novel method for the assessment of left ventricular systolic function in patients with HCM. A total of 65 patients with HCM were included ...
McKeag Nicholas A NA Centre for Public Health, School of Medicine, Dentistry & Biomedical Sciences, Queen's University, Belfast, Northern Ireland; The Heart Centre, Belfast Health & Social Care Trust, Belfast, Northern Ireland. Electronic address: - - 2014
This study sought to investigate the effect of a multiple micronutrient supplement on left ventricular ejection fraction (LVEF) in patients with heart failure. Observational studies suggest that patients with heart failure have reduced intake and lower concentrations of a number of micronutrients. However, there have been very few intervention studies investigating ...
Zhong Yong Y From Jinling Hospital, Department of Cardiology, Nanjing University, School of Medicine , Nanjing , P. R. - - 2014
Background. Myocardial bridging (MB), a common benign coronary anomaly, may bring about some unwanted complications such as angina-like chest pain. The only way of MB detection is coronary arteriography or coronary computed tomographic angiography, which is costly and invasive. This study intended to profile a panel of circulating microRNAs (miRNAs) ...
Melenovsky Vojtech V Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, MN, USA Department of Cardiology, Institute of Clinical and Experimental Medicine - IKEM, Videnska 1958/9, Prague 4 140 28, Czech Republic - - 2014
Right heart function is not well characterized in patients with heart failure and preserved ejection fraction (HFpEF). The goal of this study was to examine the haemodynamic, clinical, and prognostic correlates of right ventricular dysfunction (RVD) in HFpEF. Heart failure and preserved ejection fraction patients (n = 96) and controls ...
Rodrigo Ramón - - 2014
Acute myocardial infarction (AMI) is the leading cause of mortality worldwide. Oxidative stress has been involved in the ischemia-reperfusion injury in AMI. It has been suggested that reperfusion accounts for up to 50% of the final size of a myocardial infarct, a part of the damage likely to be prevented.Therefore, ...
Lipkova Jolana J Institute of Pathological Physiology, Faculty of Medicine, Masaryk University , Czech Republic - - 2014
It is well established that the incidence and infarct size in acute myocardial infarction (AMI) is subject to circadian variations. At the molecular level, circadian clocks in distinct cells, including cardiomyocytes, generate 24-h cycles of biochemical processes. Possible imbalance or impairment in the cell clock mechanism may alter the cardiac ...
Nakamura Akihiro A Department of Child Health, Graduate School of Comprehensive Human Sciences, University of - - 2014
Background:The aim of the present study was to assess the impact of pulmonary regurgitation (PR) and right ventricle (RV) volume on left ventricle (LV) longitudinal strain (LS) in patients with surgically repaired tetralogy of Fallot (r-TOF).Methods and Results:The study subjects were 32 adolescent asymptomatic r-TOF subjects and 30 adolescent healthy controls. Two-dimensional ...
1 2 3 4 5 6 7 8 9 10 >