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Zhao Jing-Jie JJ Clinical Molecular Biology Laboratory, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. - - 2014
The aim of the current study was to confirm the effect and elucidate the mechanism of bone marrow mesenchymal stem cells (BMSCs) in acute myocardial infarction (AMI). AMI was induced in mini‑swine by ligating the left anterior descending coronary artery, and BMSCs (1x107) were injected via a sterile microinjection into ...
Hu Xianwen X *Weil Institute of Critical Care Medicine, Rancho Mirage, California; †The Second Hospital of Anhui Medical University, Hefei, China; and ‡Keck School of Medicine of the University of Southern California, Los Angeles, - - 2014
Severe hemorrhagic shock and resuscitation is a state of global body ischemia and reperfusion that causes myocardial and cerebral dysfunction. We investigated whether remote ischemic preconditioning (RIPC) would reduce myocardial and cerebral ischemia and reperfusion injuries after hemorrhagic shock as the result of the KATP channel activation. Twenty-one male rats ...
Trulock Kevin M KM Duke Center for Atrial Fibrillation, Duke University Medical Center, Durham, North - - 2014
Because nonpharmacological interventions likely alter the risks and benefits associated with rhythm control, this paper reviews the role of current rhythm control strategies in atrial fibrillation. This report also focuses on the specific limitations of pharmacological interventions and the utility of percutaneous ablation in this growing population of patients with ...
Gujral Gina G School of Pharmacy, The University of Queensland, Brisbane, QLD, Australia, - - 2014
Background Adherence to evidence based medicines in patients who have experienced a myocardial infarction remains low. Individual's beliefs towards their medicines are a strong predictor of adherence and may influence other factors that impact on adherence. Objective To investigate if community pharmacists discussing patients' beliefs about their medicines improved medication ...
Santos Angela B S AB Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA; Postgraduate Program in Cardiovascular Sciences, Cardiology, Federal University of Rio Grande do Sul, - - 2014
Left atrial (LA) enlargement is present in the majority of heart failure with preserved ejection fraction (HFpEF) patients and is a marker of risk. However, the importance of LA function in HFpEF is less well understood. The PARAMOUNT trial enrolled HFpEF patients (LVEF ≥45%, NT-proBNP >400 pg/mL). We assessed LA reservoir, ...
Gyllenhammar Tom T Department of Clinical Physiology, Lund University, Lund University Hospital, Lund 221 85, - - 2014
To determine if myocardial perfusion (MP) during hyperaemia is decreased in young patients with hypertrophic cardiomyopathy (HCM). Also, to determine if an MP decrease is associated with diastolic dysfunction, and to investigate if young subjects at risk of HCM show differences in MP compared with controls. This study included 10 ...
Jurcut R R University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania, - - 2014
To describe morphological and functional cardiovascular changes in acromegaly (ACM) patients, as well as to investigate the ability of Doppler-based myocardial deformation imaging (DMI) to characterize subtle dysfunction in ACM. 69 patients (pts) with ACM (mean age 47 ± 10 years, 27 men) and 31 controls (mean age 43 ± 16 years, matched for age and ...
Senol Sefa S Department of Cardiovascular Surgery, Educational and Research Hospital, Elazig, Turkey - - 2014
This study compared plasminogen activator inhibitor 1 and methylenetetrahydrofolate reductase C677T and A1298C polymorphisms in patients with myocardial infarction with ST-segment elevation before undergoing to coronary artery bypass grafting, and in patients who had previously undergone coronary artery bypass grafting. Seventy patients with myocardial infarction with ST-segment elevation, scheduled to ...
Mateos Alonso A Servicio de Urgencias Médicas de Madrid SUMMA112; Centro Nacional de Investigaciones Cardiovasculares CNIC, - - 2014
We seek to examine the efficacy and safety of prereperfusion emergency medical services (EMS)-administered intravenous metoprolol in anterior ST-segment elevation myocardial infarction patients undergoing eventual primary angioplasty. This is a prespecified subgroup analysis of the Effect of Metoprolol in Cardioprotection During an Acute Myocardial Infarction trial population, who all eventually ...
El-Aziz Tarek A Abd TA Cardiology Department, Faculty of Medicine, Zagazig University, Zagazig, - - 2014
Endogenous fibrinolysis is a protective mechanism against arterial thrombotic occlusion, which would otherwise lead to permanent tissue damage as acute myocardial infarction (AMI). We aimed to investigate the association of plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (TPA) genes polymorphisms with myocardial infarction and its outcomes in Egyptian patients. ...
Zhang Hong-Ju HJ Department of Ultrasound, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167, Bei Lishi Road, Xicheng District, Beijing, 100037, People's Republic of - - 2014
We aimed to investigate whether left ventricular (LV) twist analysis can detect the extent of myocardial fibrosis in patients with hypertrophic cardiomyopathy (HCM). This prospective case-control study recruited 81 consecutive patients with HCM examined between January 2012 and April 2013. Data of 76 patients were analyzed after excluding 5 patients ...
Sadamatsu Kenji K Department of Cardiology, Saga-ken Medical Centre Koseikan, Saga, Japan. Electronic address: - - 2014
Beta-blockers are used to control the heart rate prior to coronary computed tomography (CT) angiography. However, in-hospital administration is time-consuming, and it is hard to decrease the heart rate to <60 beats per minute (bpm) when the initial heart rate is increased. In this study, we examined whether the single ...
Markowitz Steven M SM Department of Medicine, Division of Cardiology, Cornell University Medical Center, New York, NY, - - 2014
Because of prognostic and therapeutic implications, the distinction between iRVOT and arrhythmogenic RV cardiomyopathy (ARVC) is clinically important. Over the last two decades multiple reports have identified RV abnormalities using CMR in patients with idiopathic VT, suggesting a link between these arrhythmias and ARVC. The purpose of this study was ...
Pucci S S Dept. Biomedicine and Prevention, Tor Vergata University of Rome, Italy. Electronic address: - - 2014
Acute myocardial infarction (AMI), is related to a diffuse active inflammation of the coronary tree associated with rupture of one of the multiple vulnerable plaques. The presence of soluble mediators of inflammation with their synergic or antagonistic actions coordinates the physiological response determining the plaque fate and the fatal event. ...
Chen Melissa - - 2014
BackgroundWe previously demonstrated that older beagles have impaired whole body and myocardial insulin responsiveness (MIR), and that glucagon-like peptide-1 (GLP-1 [7¿36] amide) improves MIR in young beagles with dilated cardiomyopathy (DCM). Here, we sought to determine if aging alone predisposes to an accelerated course of DCM, and if GLP-1 [7¿36] ...
Santoso Teguh T Department of Internal Medicine, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, - - 2014
Prior studies suggest that endomyocardial implantation of autologous bone marrow (BM) mononuclear cell therapy improves symptoms and left ventricular (LV) function in patients with refractory angina; however, the therapeutic efficacy in patients with ischemic cardiomyopathy is unclear. In a randomized, double-blind, placebo-controlled trial, 28 patients with advanced ischemic cardiomyopathy [New ...
Soslow Jonathan H JH Division of Pediatric Cardiology, Department of Pediatrics, Vanderbilt University Medical Center, 2200 Children's Way, Suite 5230 DOT, Nashville, TN, 37232, USA, - - 2014
The objective of the study was to perform a retrospective pilot study to evaluate the potential of myocardial T1 in assessment of Duchenne muscular dystrophy (DMD) cardiomyopathy. Early identification of DMD cardiac disease, particularly myocardial fibrosis, would allow earlier therapy, potentially improving outcomes. Shortened myocardial T1 measured by cardiac MRI ...
Cakal Sinem S Department of Cardiology, Kartal Kosuyolu Yuksek Ihtisas Heart and Research Hospital, Istanbul, - - 2014
Atrial septal defect (ASD) causes chronic volume overload of the right heart. The potential adverse effects of this long-standing volume overload to left atrium (LA) and left ventricle (LV) and their response to ASD closure has been poorly studied. We studied 20 ASD patients before the procedure, at the 24-hour ...
Ankam Jyoti J Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, Maryland, - - 2014
Following a myocardial infarction, lipid-lowering therapy is an established intervention to reduce the risk of recurrent cardiovascular events. Prior studies show a need to improve clinical practice in this area. Here, we review the latest research and perspectives on improving postmyocardial infarction lipid control. Dyslipidemia and myocardial infarction remain leading ...
Webster I I University of Stellenbosch, Cape Town, South Africa, - - 2014
In isolated rat heart perfusion experiments, drug administration occurs via retrograde perfusion. This can be done in the non-recirculating mode (coronary effluent is discarded), or recirculating mode (coronary effluent is collected and reused). It was recently observed in our lab while using sanguinarine, an MKP-1 inhibitor, that there were differences ...
De Vecchis R R Cardiology Unit, Presidio Sanitario Intermedio''Elena d'Aosta'', Napoli, Italy - - - 2014
The present meta--analysis attempted to assess whether an unfavourable cardiovascular risk profile could be identified in the case of two COX2 selective inhibitors (COXIBs), namely celecoxib and etoricoxib. Based on the data from the literature, our meta--analysis aimed to assess the probability of major cardiovascular events reported with the use ...
Ilter A A Department of Cardiology, Kanuni Training and Research Hospital, Trabzon, Turkey, - - 2014
The aim of this study was to evaluate atrial electromechanical delay (EMD), P wave dispersion (Pwd), and left atrial (LA) mechanical functions in patients with active acromegaly. Twenty-three patients with active acromegaly and 27 age- and sex-matched controls were included in this study. All atrial electromechanical interval parameters (PA lateral, ...
Matsa Lova Satyanarayna LS Department of Genetics, Osmania University, Hyderabad, AP, - - 2014
Dilated cardiomyopathy (DCM) is a myocardial disease of unknown etiology with left ventricular dilatation and impaired myocardial contractility leading to heart failure. It is considered to be a multifactorial disorder with the interplay of both genetic and environmental factors. One of the possible genes implicated in DCM is endothelin 1 ...
Clemmensen Tor Skibsted TS Department of Cardiology, Aarhus University Hospital, Skejby, Denmark. Electronic address: - - 2014
Coronary allograft vasculopathy (CAV) in heart transplant (HTx) recipients is characterized by diffuse affection of epicardial and intramyocardial coronary vessels. Despite significant CAV and anticipated affected myocardial function, left ventricular ejection fraction (LVEF) is often within the normal range, indicating the need of more sophisticated non-invasive methods to detect impaired ...
Imai Masamichi M From the Division of Cardiology, Department of Medicine, Johns Hopkins University, 600 N Wolfe St, Blalock 524, Baltimore, MD 21287-0409 (M.I., B.A.V., S.S., S.D., A.C.A., J.A.C.L.); Department of Cardiology, Johns Hopkins Hospital, Baltimore, Md (M.H.); Cardiovascular Health Research Unit, Washington University, St Louis, Mo (S.R.H.); and Office of Biostatistics Research, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Md (C.O.W., - - 2014
Purpose To investigate the association between left atrial (LA) function and left ventricular myocardial fibrosis using cardiac magnetic resonance (MR) imaging in a multi-ethnic population. Materials and Methods For this HIPAA-compliant study, the institutional review board at each participating center approved the study protocol, and all participants provided informed consent. ...
Puntmann Valentina O VO From the Department of Cardiovascular Imaging, Division of Imaging Sciences and Biomedical Engineering (V.O.P., E.A.U., R.H.B., N.B.N., Y.-S.K., D.D., A.M., C.C., S.P., G.C.-W., E.N.), Department of Biomedical Engineering, Division of Imaging Sciences and Biomedical Engineering (N.G.), and Cardiovascular Division (P.C.), King's College London, United Kingdom; Department of Radiology, University of Bonn, Germany (D.D.); Philips Healthcare, United Kingdom (D.M.H.); and University of Leeds, United Kingdom (S.P.). - - 2014
Increased aortic stiffness is related to increased ventricular stiffness and remodeling. Myocardial fibrosis is the pathophysiological hallmark of failing heart. We investigated the relationship between noninvasive imaging markers of myocardial fibrosis, native T1, and late gadolinium enhancement, respectively, and aortic stiffness in ventricular remodeling. Consecutive patients with known dilated cardiomyopathy ...
Mehta Puja K PK Barbra Streisand Women's Heart Center, Cedars-Sinai Heart Institute, Los Angeles, CA, United - - 2014
Heart rate variability (HRV) is reduced in stable ischemic heart disease (SIHD) patients and is associated with sudden cardiac death (SCD). We evaluated the impact of traditional acupuncture (TA) on cardiac autonomic function measured by HRV in SIHD patients. We conducted a randomized controlled study of TA, sham acupuncture (SA), ...
Gregory Shaun D SD School of Medicine, University of Queensland, Brisbane, Queensland, Australia; Innovative Cardiovascular Engineering and Technology Laboratory, The Prince Charles Hospital, Brisbane, Queensland, Australia; Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, - - 2014
Biventricular support with dual rotary ventricular assist devices (VADs) has been implemented clinically with restriction of the right VAD (RVAD) outflow cannula to artificially increase afterload and, therefore, operate within recommended design speed ranges. However, the low preload and high afterload sensitivity of these devices increase the susceptibility of suction ...
Halladin Natalie L NL Department of Surgery, Herlev Hospital, University of Copenhagen, Herlev, Denmark - - 2014
Aim: To test whether melatonin reduces oxidative and inflammatory biomarkers in a closed-chest porcine model of acute myocardial infarction. Materials and Methods: Twenty pigs were randomized to receive a total dosage of 200 mg (0.4 mg/ml) of melatonin, or placebo immediately prior to reperfusion of a coronary artery balloon occlusion ...
Brauer Ruth R Department of Non-Communicable Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK - - 2014
Antipsychotics increase the risk of stroke. Their effect on myocardial infarction remains uncertain because people prescribed and not prescribed antipsychotic drugs differ in their underlying vascular risk making between-person comparisons difficult to interpret. The aim of our study was to investigate this association using the self-controlled case series design that ...
Sheriff Ahmed A Department of Nephrology and Internal Intensive Care Medicine, Charité - Universitätsmedizin Berlin, Berlin, - - 2014
Background: There is substantial evidence that C-reactive protein (CRP) mediates secondary damage of the myocardium after acute myocardial infarction (AMI). The aim of this animal trial in pigs was to specifically deplete CRP from porcine plasma after AMI and to study possible beneficial effects of the reduced CRP concentration on ...
Tendera Michal M Medical University of Silesia, Katowice, - - 2014
To use CLARIFY, a prospective registry of patients with stable CAD (45 countries), to explore heart rate (HR) control and beta-blocker use. We analyzed the CLARIFY population according to beta-blocker use via descriptive statistics with Pearson's χ(2) test for comparisons, as well as a multivariable stepwise model. Data on beta-blocker ...
Vriesendorp Pieter A PA Department of Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, the - - 2014
Adverse left ventricular (LV) remodeling predicts heart failure symptoms and overt LV dysfunction in patients with hypertrophic cardiomyopathy (HCM), but its influence on the occurrence of sudden cardiac death (SCD) is unknown. The aim of this study was to investigate the effect of adverse LV remodeling on SCD risk in ...
Toldo Stefano S *Virginia Commonwealth University Pauley Heart Center, Virginia Commonwealth University, Richmond, VA; †Victoria Johnson Research Laboratories, Virginia Commonwealth University, Richmond, VA; and ‡Department of Pharmacotherapy and Outcome Studies, Virginia Commonwealth University, Richmond, - - 2014
Interleukin-1β (IL-1β) modulates the inflammatory response during acute myocardial infarction (AMI) and progression to ischemic cardiomyopathy. We investigated whether blockade of IL-1β after the onset of the cardiac dysfunction prevented left ventricular (LV) adverse remodeling in a mouse model of anterior nonreperfused AMI. Infarct size and LV systolic function were ...
Miao Qingfeng Q National Heart Research Institute Singapore, National Heart Centre Singapore, - - 2014
We investigated global and regional effects of myocardial transplantation of human induced pluripotent stem cell (iPSC)-derived mesenchymal stem cells (iMSCs) in infarcted myocardium. Acute myocardial infarction (MI) was induced by ligation of left coronary artery of severe combined immunodeficient mice before 2 × 10(5) iMSCs or cell-free saline were injected into peri-infarcted ...
Andrade-Castellanos Carlos A CA Department of Internal Medicine, Hospital Civil de Guadalajara "Dr. Juan I. Menchaca", Salvador Quevedo y Zubieta No. 750, Guadalajara, Jalisco, Mexico, - - 2014
Non-ST elevation acute coronary syndromes (NSTEACS) represent a spectrum of disease including unstable angina and non-ST segment myocardial infarction (NSTEMI). Despite treatment with aspirin, beta-blockers and nitroglycerin, unstable angina/NSTEMI is still associated with significant morbidity and mortality. Although evidence suggests that low molecular weight heparin (LMWH) is more efficacious compared ...
Chen Junyu J Department of Cardiology, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, Guangdong, People's Republic of - - 2014
Cardiac resynchronization therapy can treat chronic heart failure through either biventricular pacing (BVP) or isolated left ventricular pacing (LVP), and the efficacy is depended on QRS duration. However, the optimal therapeutic choice of pacing or how the QRS influences the efficacy remains uncertain. To investigate this uncertainty, we searched available ...
Huynh William W Prince of Wales Clinical School, University of New South Wales, Sydney, NSW, Australia, - - 2014
The cerebellum has a vital role in fine motor control of the limbs. Consequently, downstream changes in peripheral axonal function may develop following a cerebellar infarct, in part, to adapt to the resultant impairment. The present study investigated changes in excitability in ipsilateral and contralateral upper limb peripheral motor axons ...
Martinez C - - 2014
It was the aim of this study to determine prognosis of incidentally detected ambulatory atrial fibrillation (IA-AF) and its response to antithrombotic therapy. We performed a cohort study of 5,555 patients with IA-AF (mean age 70.9 ± 10.1, 38.4% female) and 24,705 age- and gender-matched controls without AF followed three ...
Lipkova Jolana J Faculty of Medicine, Institute of Pathological Physiology, Masaryk University, Kamenice 753/5, 625 00, Brno, Czech - - 2014
Chemokines, including RANTES, play a crucial role in the processes of inflammation during cardiovascular disorders, including myocardial infarction, disease progression and complications. This study aimed to evaluate the role of RANTES -403G/A polymorphism and levels in circulation in processes of development and progression of myocardial infarction and cardiogenic shock. A ...
Gazi Emine E Department of Cardiology, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, - - 2014
Objective: To investigate intercellular adhesion molecule-1 (ICAM1) and angiotensinogen (AGT) gene polymorphisms, as related to atherosclerosis and endothelial dysfunction, in coronary slow flow (CSF). Subjects and Methods: The participants in this study were 48 patients with CSF and 67 patients with normal coronary flow as controls. The K469E polymorphism of ...
Deng Yan Y Department of Ultrasound, The First Affiliated Hospital of Guangxi Medical University, Nanning, - - 2014
This study evaluated the feasibility of assessing left atrium (LA) function and asynchrony in patients with rheumatic mitral stenosis (MS) before and immediately after percutaneous balloon mitral valvuloplasty (PBMV) by real time three-dimensional echocardiography (RT3DE). Thirty patients with rheumatic MS who underwent PBMV and 30 controls were enrolled. RT3DE was ...
Hwang Hyosook H From the Department of Nuclear Medicine, Molecular Imaging and Therapeutic Medicine Research Center, Cyclotron Research Center, Institute for Medical Sciences, and Biomedical Research Institute, Chonbuk National University Medical School and Hospital, 634-18 GeumAm-dong Duckjin-gu Jeonju-si, Jeollabuk-do 561-803, South Korea (H.H., J.K., P.S.O., T.K.L., K.S.N., H.S.J., S.T.L., M.H.S., H.J.J.); and Department of Biomedical Engineering, Chonnam National University, Yeosu, South Korea - - 2014
Purpose To determine whether chitosan hydrogel nanoparticles loaded with vascular endothelial growth factor (VEGF) peptides (81-91 fragments) capable of targeting the ischemic myocardium enhance angiogenesis and promote therapeutic effects and whether radionuclide image-guided dosage control is feasible. Materials and Methods Experimental procedures and protocols were approved by the Institutional Animal ...
Liu Xiao-Yan XY aCenter for Arrhythmia Diagnosis and Treatment, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China bSchool of Biomedical Sciences, Charles Sturt University, Wagga Wagga, New South Wales, - - 2014
The variation of the substrates of verapamil-sensitive idiopathic left ventricular tachycardia (ILVT) was not understood. The purpose of this study was to investigate the variation of electroanatomic substrate [slow conduction zone (SCZ) and left ventricular conduction system (LVCS)] in ILVT and control individuals and markers of successful ablation. Electroanatomical mapping ...
Agati L L Department of Cardiology, 'Sapienza' University, Viale del Policlinico 155, Roma 00161, Italy - - 2014
Left ventricular (LV) diastolic filling is characterized by the formation of a vortex that supports an efficient transit into systolic ejection. Aim of this study was to assess the intraventricular (IV) blood flow dynamics among patients with ST elevated myocardial infarction (STEMI) at different degrees of LV dysfunction, in the ...
Patel Neil N Sullivan University College of Pharmacy , Louisville, KY , USA - - 2014
Abstract Background: Increased NF-κB levels play a crucial role in the pathophysiology of heart failure and are known to cause ventricular remodeling. Antisense therapy can be used for blocking the expression of NF-κB and subsequently avoiding heart failure. However, as with most biotechnology products, molecular instability and overall cost are ...
Graça Bruno B 1 Faculty of Medicine, University of Coimbra, Azinhaga de Santa Comba, 3000-548, Coimbra, - - 2014
OBJECTIVE. The purpose of this study was to compare cardiac MRI-derived parameters of left ventricular (LV) diastolic function between uncomplicated type 2 diabetes mellitus (DM2) and normoglycemic control subjects and to evaluate whether these parameters of LV diastolic function are related to coronary atherosclerosis. SUBJECTS AND METHODS. We prospectively studied ...
Llewellyn Michael E ME Departments of Radiology (M.E.L., R.B.J., E.W.O.) and Pathology (M.A.D.), Stanford University School of Medicine, Stanford, California USA; and Radiology Service, Veterans Affairs Palo Alto Health Care System, Palo Alto, California USA - - 2014
To evaluate the frequency of the "bright band sign" in patients with splenic infarcts as well as control patients and to thereby assess whether the bright band sign has potential utility as a sonographic sign of splenic infarction. Using an electronic search engine and image review, 37 patients were retrospectively ...
Liu Liwen L Department of Ultrasound, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. - - 2014
The early detection of abnormal left ventricular systolic functions in patients with hypertrophic cardiomyopathy (HCM) remains a challenge. The aim of this study was to identify a novel method for the assessment of left ventricular systolic function in patients with HCM. A total of 65 patients with HCM were included ...
McKeag Nicholas A NA Centre for Public Health, School of Medicine, Dentistry & Biomedical Sciences, Queen's University, Belfast, Northern Ireland; The Heart Centre, Belfast Health & Social Care Trust, Belfast, Northern Ireland. Electronic address: - - 2014
This study sought to investigate the effect of a multiple micronutrient supplement on left ventricular ejection fraction (LVEF) in patients with heart failure. Observational studies suggest that patients with heart failure have reduced intake and lower concentrations of a number of micronutrients. However, there have been very few intervention studies investigating ...
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