Search Results
Results 301 - 350 of 1332
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Heijman Jordi - - 2013
Atrial fibrillation (AF) and heart failure (HF) are common cardiovascular pathologies with severe prognostic implications that show bidirectional interactions. Rate and rhythm control are the main therapeutic strategies for patients with AF and HF. There is a paucity of safe and effective antiarrhythmic drugs for rhythm control of AF in ...
Kirchhof Paulus - - 2013
Even on optimal therapy including anticoagulation and rate control, major cardiovascular complications (stroke, cardiovascular death, and acute heart failure) are common in patients with atrial fibrillation (AF). Conceptually, maintenance of sinus rhythm could prevent adverse outcomes related to AF. Rhythm control therapy has been only moderately effective in published trials, ...
Mazzone Carmine - - 2013
Limited information is available on left atrial (LA) work in chronic heart failure (CHF) patients. We evaluated correlates and prognostic role of LA work in 243 CHF patients using as reference for normal LA work values 230 healthy controls. Left atrial work was assessed by computation of LA kinetic energy ...
Hinkel Rabea - - 2013
MicroRNAs (miRs) are small non-coding RNAs that posttranscriptionally control gene expression. Small animal studies suggest that miRs might offer novel therapeutic targets in cardiovascular disease, such as cardioprotection of murine hearts after myocardial infarction via miR-92a inhibitors. Since the functional benefits of miR-92a inhibitors in larger pre-clinical models are not ...
Khan Muhammad A - - 2013
Heart failure (HF) and atrial fibrillation (AF) frequently coexist and have emerged as major cardiovascular epidemics. There is growing evidence that AF is an independent prognostic marker in HF and affects patients with both reduced as well as preserved LV systolic function. There has been a general move in clinical ...
Ajijola Olujimi A OA University of California-Los Angeles (UCLACardiac Arrhythmia Center, UCLA, Los Angeles, - - 2013
Myocardial infarction (MI) induces neural and electrical remodeling at scar border zones. The impact of focal MI on global functional neural remodeling is not well understood. Sympathetic stimulation was performed in swine with anteroapical infarcts (MI; n = 9) and control swine (n = 9). A 56-electrode sock was placed ...
Garcia Rodriguez L A - - 2013
Some pharmacokinetic studies have reported that proton pump inhibitors (PPIs) reduce the activity of clopidogrel, but the results of studies assessing clinical outcomes in patients receiving both drugs are inconsistent. We have therefore carried out a population-based cohort study with nested case-control analysis, in order to evaluate changes in the ...
Rufaihah Abdul Jalil - - 2013
Most tissue engineering therapies require biomaterials that are able to induce an angiogenic response to support tissue regeneration. In addition angiogenic growth factor signaling plays an essential role in controlling the process of angiogenesis and matrices have the potential of regulating the concentration of growth factors within the cellular microenvironment. ...
Alasady Muayad - - 2013
-Myocardial infarction (MI) is associated with the development of atrial fibrillation (AF). We aimed to characterize the atrial abnormalities due to MI and determine the role of ischemia to the AF substrate. Method and Results-Forty-four sheep were studied. MI was induced by occlusion of the circumflex artery (LCX) or left ...
Marfella Raffaele - - 2013
We examined the effects of peri-procedural intensive glycemic control during early percutaneous coronary intervention (PCI) on the number and differentiation of endothelial progenitor cells (EPCs) and myocardial salvage (MS) in hyperglycemic patients with first ST-elevation myocardial infarction (STEMI). We conducted a randomized, prospective, open label study on 194 patients with ...
Schmidt Michael R - - 2013
Remote ischemic preconditioning (rIPC) reduces myocardial injury in adults and children undergoing cardiac surgery. We compared the effect of rIPC in adult and neonatal rabbits to investigate whether protection against ischemia-reperfusion injury can be achieved in the newborn heart by (1) in vivo rIPC and (2) dialysate from adult rabbits undergoing ...
Madder Ryan D RD Frederik Meijer Heart and Vascular Institute, Spectrum Health, Grand Rapids, Michigan 49503, USA. - - 2013
This study sought to describe near-infrared spectroscopy (NIRS) findings of culprit lesions in ST-segment elevation myocardial infarction (STEMI). Although autopsy studies demonstrate that most STEMI are caused by rupture of pre-existing lipid core plaque (LCP), it has not been possible to identify LCP in vivo. A novel intracoronary NIRS catheter ...
Sutter M E - - 2013
Abstract Background. Methamphetamine (METH) has been associated with a dilated cardiomyopathy. The first and rate-limiting step of metabolism is dependent on the polymorphic enzyme CYP2D6. Objectives. To evaluate if polymorphisms in CYP2D6 can be associated with the development of a methamphetamine-induced cardiomyopathy. Methods. We performed a prospective case-control pilot study. ...
Wensley Isaac - - 2013
Obesity and its co-morbidities (dyslipidaemia, insulin resistance and hypertension) that together constitute the metabolic syndrome (MetS) are all risk factors for ischaemic heart disease (IHD). Although obesity has been reported to be an independent risk factor for congestive heart failure (CHF), whether obesity induced heart failure develops in the absence ...
Birnie David - - 2013
Acute studies have suggested that left ventricular pacing (LVP) may have benefits over biventricular pacing (BVP). The adaptive cardiac resynchronization therapy (aCRT) algorithm provides LVP synchronized to produce fusion with the intrinsic activation when the intrinsic atrioventricular (AV) interval is normal. The randomized double-blind adaptive cardiac resynchronization therapy trial demonstrated ...
Csáky-Szunyogh Melinda - - 2013
The aim of our project was to study possible etiological factors in the origin of congenital heart defects (CHDs) because in the majority of patients the underlying causes are unclear. Cases with different CHD entities as homogeneously as possible were planned for evaluation in the population-based large data set of ...
Abe Yuriko - - 2013
We present a case of a 9-month-old girl in whom malignant polymorphic ventricular tachycardia (VT) was successfully controlled by radiofrequency catheter ablation under guidance with a three-dimensional mapping system. The VTs originated from the left ventricular lateral wall, left ventricular anterior wall, and left ventricular apex. At least six types ...
Nakamori Shiro - - 2013
Recent studies have demonstrated that chronic obstructive pulmonary disease (COPD) is associated with cardiovascular disease (CVD). However, the association between COPD and coronary microcirculatory dysfunction is unknown. We sought to assess whether myocardial perfusion reserve (MPR) is impaired in patients with COPD, even in the absence of regional myocardial ischaemia ...
Dogan Cem C - - 2013
In patients presenting with ST-elevation myocardial infarction (STEMI), we investigated the relation of left atrial (LA) deformational parameters evaluated by two-dimensional speckle tracking imaging (2D-STI) with conventional echocardiographic diastolic dysfunction parameters and B-type natriuretic peptide (BNP) level. We enrolled 89 STEMI patients who were treated with primary percutaneous coronary intervention ...
Ledwidge Mark M Chronic Cardiovascular Disease Management Unit, St Vincent's Healthcare Group/St Michael's Hospital, Dublin, - - 2013
Prevention strategies for heart failure are needed. To determine the efficacy of a screening program using brain-type natriuretic peptide (BNP) and collaborative care in an at-risk population in reducing newly diagnosed heart failure and prevalence of significant left ventricular (LV) systolic and/or diastolic dysfunction. The St Vincent's Screening to Prevent ...
Khan Fauzia A - - 2013
Several drugs have been used in attenuating or obliterating the response associated with laryngoscopy and tracheal intubation. These changes are of little concern in relatively healthy patients but can lead to morbidity and mortality in the high risk patient population. The primary objective of this review was to determine the ...
Hilde Janne Mykland - - 2013
The present study aimed to elucidate RV function and structure in COPD patients without PH. There is little knowledge of RV function and remodeling in COPD without PH. Thirty-four controls and 98 patients with COPD were included. The patient population was divided in two groups by right heart catheterization, no-PH ...
Basu Sanjay - - 2013
We simulated tobacco control and pharmacological strategies for preventing cardiovascular deaths in India, the country that is expected to experience more cardiovascular deaths than any other over the next decade. A microsimulation model was developed to quantify the differential effects of various tobacco control measures and pharmacological therapies on myocardial ...
Lawrance Jesuraj M - - 2013
Focal atrial tachycardias (AT) in the right atrium (RA) tend to cluster around the crista terminalis, coronary sinus (CS) region, tricuspid annulus, and para-hisian region. In most cases, the AT focus can be identified by careful activation mapping, and completely eliminated by radiofrequency (RF) catheter ablation. However, RF ablation near ...
Pisarenko Oleg I OI Russian Cardiology Research-and-Production Complex, Institute of Experimental Cardiology, Moscow, Russian - - 2013
To examine cardioprotective effects of Ρ-terminal fragment of adipokine apelin-12 (A12), its novel structural analogue [MeArg(1), NLe(10)]-A12 (I), and [d-Ala(12)]-A12 (II), a putative antagonist of APJ receptor, employing in vivo model of ischemia/reperfusion (I/R) injury. Peptides were synthesized by the automatic solid phase method using Fmoc technology. Anesthetized open-chest male ...
Speranza L - - 2013
Heart failure (HF) is a common clinical syndrome with frequent exacerbations requiring hospitalization. Among the various mechanisms that underlie the pathogenesis of HF, the activation of the immune system leads to a progressive and redundant release of proinflammatory cytokines responsible for a variety of deleterious effects in heart failure, such ...
Inada Shin - - 2013
The atrioventricular (AV) node, which is located between the atria and ventricles of the heart, acts as important roles in cardiac excitation conduction between the two chambers. Although there are multiple conduction pathways in the AV node, the structure of the AV node has not been clarified. In this study, ...
Alings M - - 2013
Rhythm control for atrial fibrillation (AF) is cumbersome because of its progressive nature caused by structural remodelling. Upstream therapy refers to therapeutic interventions aiming to modify the atrial substrate, leading to prevention of AF. The Routine versus Aggressive upstream rhythm Control for prevention of Early AF in heart failure (RACE ...
Decloedt Annelies - - 2013
Atrial fibrillation (AF) causes atrial electrical and contractile remodelling in horses. The aim of this study was to quantify left atrial (LA) contractile function and its time course of recovery after cardioversion of naturally-occurring AF in horses. The study population included 42 AF horses which were successfully treated using transvenous ...
Abukonna Ahmed - - 2013
The heart rate is largely under control of the autonomic nervous system. The aim of the present study is to investigate interactions between the brain and heart underlying volitional control of the heart and to explore the effectiveness of volition as a strategy to control heart rate without biofeedback. Twenty ...
Crendal Edward - - 2013
Objective: We aimed to characterize left ventricular (LV) myocardial mechanics in adults with metabolic syndrome (MetS), and elucidate the effects of multiple risk-factors on myocardial function using speckle tracking echocardiography (STE); a more sensitive method than conventional echocardiography for detecting subclinical myocardial dysfunction. Design and Methods: Cross-sectional analyses of 92 ...
Dai Hongyan - - 2013
Nesfatin-1 is a novel anorexigenic hormone which has close relationship with diabetes, obese, anorexia nervosa, psychiatric disorders and neurogenic diseases. The aim of our study was to evaluate levels of plasma nesfatin-1 among patients presenting with coronary artery disease and the correlation between nesfatin-1 levels and other clinical parameters. Fasting ...
Cheng Kang - - 2013
Intramyocardial cellular delivery provides a promising therapeutic strategy for ischaemic cardiac dysfunction. However, individual studies have reported controversial results. Relevant trials were identified by systematic search of MEDLINE, EMBASE, the Cochrane database, and CINAH database. Studies, which applied randomised design and compared intramyocardial cell injection with placebo or optimal medical ...
Nelson Michael D MD The Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, Los Angeles, - - 2013
Generalized lipodystrophy is a rare disorder characterized by marked loss of adipose tissue with reduced triglyceride storage capacity, leading to a severe form of metabolic syndrome including hypertriglyceridemia, insulin resistance, type 2 diabetes mellitus, and hepatic steatosis. Recent echocardiographic studies suggest that concentric left ventricular (LV) hypertrophy is another characteristic ...
Hothi Daljit K - - 2013
In adults, recurrent hemodialysis (HD)-induced cardiac injury results in ischemic myocardial dysfunction. Uremic children, like adults, share the full complement of uremia-related cardiovascular abnormalities but without significant atheromatous coronary artery disease. The aim of this study was, to assess the impact of HD on left ventricular (LV) myocardial function in ...
Peters Ferande - - 2013
Left ventricular (LV) twist is an important component of systolic function. The effect of abnormal LV twist on adverse remodelling of the heart in left ventricular noncompaction (LVNC) is unknown. This study used speckle-tracking echocardiography to evaluate LV twist in patients with LVNC and determine whether abnormal LV twist is ...
Sun Yuhan - - 2013
We performed a meta-analysis to compare therapeutic outcome/safety of drug-eluting stent (DES) and conventional in-stent restenosis (ISR) treatments. We browsed through large volume of clinical data by searching MEDLINE, EMBASE, Cochrane central register of controlled trials, and EBSCO databases. In this study, 11 randomized controlled trials, 17 non-randomized controlled trials, ...
Abd El Rahman Mohamed Y - - 2013
To assess regional longitudinal systolic function of the right ventricle in patients with repaired tetralogy of Fallot (TOF) by tissue Doppler imaging-derived isovolumetric acceleration (IVA) index and determine the effect of right-ventricular (RV) enlargement on regional systolic function. In 30 consecutive TOF patients and 30 age-matched controls, myocardial velocity of ...
Goldfarb James W - - 2013
PURPOSE: To quantitatively investigate myocardial phase in multiple-gradient-echo images to determine normal phase angle ranges as a function of echo time and anatomical position and then compare phase values from patients with myocardial infarction with those normal ranges to determine the feasibility of intramyocardial hemorrhage detection. METHODS: Fifteen normal control ...
Hacihamdioglu Duygu Ovunc - - 2013
BACKGROUND: QT dispersion and JT dispersion are simple noninvasive arrhythmogenic markers that can be used to assess the homogeneity of cardiac repolarization. The aim of this study was to assess QT and JT dispersion and their relation with left ventricular systolic and diastolic functions in children with Bartter syndrome (BS). ...
Gordts S C - - 2013
Post-myocardial infarction (MI) ejection fraction is decreased in patients with low high-density lipoprotein (HDL) cholesterol levels, independent of the degree of coronary atherosclerosis. The objective of this study is to evaluate whether selective HDL-raising gene transfer exerts cardioprotective effects post MI. Gene transfer in C57BL/6 low-density lipoprotein receptor (LDLr)(-/-) mice ...
Leban Nadia - - 2013
BACKGROUND: Myocardial infarction (MI) is a major clinical problem because of its large contribution to mortality. The genetic bases of this disease have been widely studied in recent years to find a clear association with some genetic markers that increase the risk of its occurrence. In the present investigation, the ...
Mulder Bart A - - 2013
AIMS: It is unknown whether lenient rate control is an acceptable strategy in patients with AF and heart failure. We evaluated differences in outcome in patients with AF and heart failure treated with lenient or strict rate control. METHODS AND RESULTS: This post-hoc analysis of the RACE II trial included ...
Sakata Yasuhiko - - 2013
BACKGROUND: Although angiotensin receptor blockers (ARBs) are now one of the first-line drug classes for the management of hypertension, recommendations for the management of chronic heart failure (CHF) are limited. The supplemental benefit of angiotensin receptor blocker in hypertensive patients with stable heart failure using olmesartan (SUPPORT) trial investigates whether ...
Su Qiang - - 2013
BACKGROUND: To evaluate the clinical efficacy and safety of intracoronary verapamil injection in the prevention and treatment of coronary no-reflow after percutaneous coronary intervention (PCI). HYPOTHESIS: Intracoronary verapamil injection may be beneficial in preventing no-reflow/slow-flow after PCI. METHODS: We searched PubMed, Embase, and the Cochrane Central Register of Controlled Trials ...
Hu Ze-Ping - - 2013
Background and OBJECTIVES: Myocardial hypertrophy and fibrosis are important determinants of congestive heart failure. Previous work has shown that hepatocyte growth factor (HGF) can reduce acute myocardial injury and tissue fibrosis. This study was designed to examine the effects of HGF on myocardial remodeling following sustained hypertension.Methods and RESULTS: There ...
Weber Helmut - - 2013
AIMS: To evaluate laser lesion formation in the beating hearts of dogs by using an open-irrigated electrode-laser mapping and ablation heart catheter.METHODS AND RESULTS: A total of 50 laser applications at 15 W (n = 31) and 20 W (n = 19) for 10-50 s, with an irrigation flow of ...
Tidholm A - - 2013
BACKGROUND: Real-time 3-dimensional (RT3D) echocardiography provides a novel technique for assessing left atrial ejection fraction (LAEF) in dogs. HYPOTHESIS: Left atrial ejection fraction is associated with severity of myxomatous mitral valve disease (MMVD). ANIMALS: Privately owned dogs; 101 with MMVD and 52 healthy control dogs. METHODS: Prospective observational study using ...
Ratkov Isidora - - 2013
The aim of this study was to investigate which one among possible risk factors are independently related to first nonfatal myocardial infarction (MI) in Belgrade population. Case-control study was conducted in Belgrade during the period 2005-2006. Case group comprised 100 subjects 35-80 years old who were hospitalized because of first ...
Sabbah Hani N - - 2013
The study tested the hypothesis that augmentation of the left ventricular (LV) wall thickness with direct intramyocardial injections of alginate hydrogel implants (AHI) reduces LV cavity size, restores LV shape, and improves LV function in dogs with heart failure (HF). Progressive LV dysfunction, enlargement, and chamber sphericity are features of ...
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