Search Results
Results 251 - 300 of 1319
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Delewi Ronak - - 2013
The objective of the present analysis was to systematically examine the effect of intracoronary bone marrow cell (BMC) therapy on left ventricular (LV) function after ST-segment elevation myocardial infarction in various subgroups of patients by performing a collaborative meta-analysis of randomized controlled trials. We identified all randomized controlled trials comparing ...
Mewton Nathan N Cardiology Division, Centre d'Investigation Clinique de Lyon (CIC), Groupement Hospitalier Est, Hôpital Louis Pradel, Hospices Civils de Lyon, 28 avenue Doyen Lépine, 69677, Bron, France, - - 2013
After acute myocardial infarction, the presence of no-reflow (or microvascular obstruction: MVO) has been associated with adverse left ventricular (LV) remodeling and worse clinical outcome. This study examined the effects of mechanical ischemic postconditioning on early and late MVO size in acute ST-elevation myocardial infarction (STEMI) patients. Fifty patients undergoing ...
Leung Chung Ho - - 2013
Coronary effluent from an isolated perfused heart undergoing ischemic preconditioning can be transferred to precondition another naïve isolated heart. We investigated the effects of this effluent on mitochondrial integrity and function following a global infarct model of ischemia/reperfusion and the role of adenosine in this model of remote preconditioning. Coronary ...
Lassaletta Antonio D AD Division of Cardiothoracic Surgery, Cardiovascular Research Center, Warren Alpert Medical School, Brown University, Providence, RI (A.D.L., N.Y.E., Y.L., J.F., T.A.B., N.W.K., F.W.S.); and Cardiology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA - - 2013
Moderate alcohol consumption is known to be cardioprotective compared with either heavy drinking or complete abstinence. We assessed the hypothesis that ethanol supplementation would improve myocardial function in the setting of chronic ischemia. Sixteen male Yorkshire swine underwent placement of an ameroid constrictor into the left circumflex artery to induce ...
Hutchinson Mathew D - - 2013
The outflow tract (OT) regions of the right and left ventricles, common sites of origin for idiopathic ventricular arrhythmias (VA), have complex three-dimensional anatomical relationships. The understanding of in situ or "attitudinal" relationships not only informs the electrocardiographic interpretation of VA site of origin, but also facilitates their catheter-based mapping ...
Zusterzeel Robbert - - 2013
Arrhythmogenic right-ventricular cardiomyopathy (ARVC) can lead to RV dilatation. We hypothesized that electrocardiographic characteristics including QRS amplitudes in the extremity- and precordial leads, the S amplitude in lead V1 , and extent of T-wave negativity over the precordial leads are related to RV dilatation in this condition. In 42 ARVC ...
Grodin Justin L - - 2013
With the astounding morbidity and mortality associated with heart failure (HF), preventive approaches have been explored. Controlling hypertension to prevent HF is well-established, especially with sodium restriction and thiazide-based antihypertensive therapies showing potential advantages. Control of dyslipidemia with aggressive statin therapy is particularly beneficial in preventing HF in the setting ...
Werdan Karl - - 2013
Despite advances in coronary revascularization and widespread use of primary percutaneous interventions, cardiogenic shock complicating an acute ST-elevation myocardial infarction (CSMI) remains a clinical challenge with high mortality rates. Conservative management with catecholamines is associated with serious limitations, including arrhythmias, increased myocardial oxygen consumption, and inadequate circulatory support. Clinicians have ...
Guay Joanne - - 2013
To re-evaluate the effects of adding a statin before surgery on mortality at 30 days and at 1 year and on major morbidity at 0-30 days. A meta-analysis of parallel, randomized, controlled trials published in English. A university-based electronic search. Adult patients undergoing any type of procedure. Adding a statin ...
Thiele Holger H University of Leipzig-Heart Centre, Leipzig, Germany. Electronic address: - - 2013
In current international guidelines the recommendation for intra-aortic balloon pump (IABP) use has been downgraded in cardiogenic shock complicating acute myocardial infarction on the basis of registry data. In the largest randomised trial (IABP-SHOCK II), IABP support did not reduce 30 day mortality compared with control. However, previous trials in ...
Ibanez Borja B From Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain (B.I., G.P., L.F.-F., A.M., A.F.-O., J.M.G.-R., A.G.-A., J.J.B., P.L.-R., R.F.-J., M.D.R., N.E., J.G.-P., D.S.-R., S.P., G.S., V.F.); Hospital Clínico San Carlos-IdISSC, Madrid, Spain (B.I., C.M., A.F.-O., R.F.-J., B.R.-M., C.A., J.C.G.-R., R.H.-A.); Servicio de Urgencia Médica de Madrid (SUMMA 112), Madrid, Spain (V.S.-B., A.M., J.V., M.J.F.-C.); Hospital Universitario Quirón, Madrid, Spain (G.P., J.A.C.); Complejo Hospitalario Universitario de Vigo-Meixoeiro, Pontevedra, Spain (A.I., M.A.); Hospital Universitario de la Princesa, Madrid, Spain (J.J.-B., T.B.); Hospital Universitario Puerta de Hierro, Madrid, Spain (J.G.); Servicio de Emergencia Medica 061 de Galicia-Sur, Galicia, Spain (J.A.I.-V.); Hospital Universitario León, León, Spain (A.P.d.P., C.C., F.F.-V.); Servicio de Atención Médica Urgente (SAMUR)-Protección Civil, Madrid, Spain (I.C.); Hospital Universitario Doce de Octubre, Madrid, Spain (A.A.); Hospital Universitario Marqués de Valdecilla, Santander, Spain (J.M.d.l.T.-H.); London School of Hygiene & Tropical Medicine, London, UK (S.P.); and the Zena and Michael A. Wiener CVI, Mount Sinai School of Medicine, New York, NY - - 2013
The effect of β-blockers on infarct size when used in conjunction with primary percutaneous coronary intervention is unknown. We hypothesize that metoprolol reduces infarct size when administered early (intravenously before reperfusion). Patients with Killip class II or less anterior ST-segment-elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention within 6 hours ...
Steg Philippe Gabriel - - 2013
Cangrelor is a potent, rapid-acting, reversible intravenous platelet inhibitor that was tested for percutaneous coronary intervention (PCI) in three large, double-blind, randomised trials. We did a pooled analysis of data from three trials that assessed the effectiveness of cangrelor against either clopidogrel or placebo in PCI. This prespecified, pooled analysis ...
Malliaras Konstantinos - - 2013
To report full 1-year results, detailed magnetic resonance imaging (MRI) analysis, and determinants of efficacy in the prospective randomized controlled CADUCEUS trial. Cardiosphere-derived cells (CDCs) exert regenerative effects at 6 months in the CADUCEUS trial. Complete results at the final 1 year endpoint are unknown. Autologous CDCs (12.5-25x10(6)) grown from ...
Shufelt Chrisandra L CL Barbra Streisand Women's Heart Center Cedars-Sinai Medical Center, Los Angeles, CA, - - 2013
We sought to comparatively assess cardiac magnetic resonance imaging (CMRI) myocardial perfusion reserve index (MPRI) in women with confirmed microvascular coronary dysfunction (MCD) cases and reference control women. Women with signs or symptoms of myocardial ischemia in the absence of obstructive coronary artery disease (CAD) frequently have MCD which carries ...
Topal Nurdan Papila NP Department of Cardiology, Faculty of Medicine, Marmara University, Istanbul, - - 2013
Published reports demonstrate improved myocardial reperfusion with adjunctive thrombus aspiration in ST-elevation myocardial infarction (STEMI). However, implementation of this procedure without angioplasty or stent implantation is not clear. In this report, we present an octogenarian with inferior STEMI who was treated with thrombus aspiration alone. Another important feature of our ...
Lin Heng-Hsu - - 2013
Symptoms of heart failure with preserved left ventricular systolic function are common among patients undergoing peritoneal dialysis (PD). Epicardial fat (EpF) is an ectopic fat depot with possible paracrine or mechanical effects on myocardial function. The aim of our current study is to assess the association between EpF and Left ...
Rodrigo Sander F - - 2013
In experimental studies, mesenchymal stem cell (MSC) transplantation in acute myocardial infarction (AMI) models has been associated with enhanced neovascularization and myogenesis. Clinical data however, are scarce. Therefore, the present study evaluates the safety and feasibility of intramyocardial MSC injection in nine patients, shortly after AMI during short-term and 5-year ...
Kong Min - - 2013
The present study was conducted to investigate the prevalence of multifocal infarcts and multifocal villous clumps, as well as the expression of α‑smooth muscle actin (α‑SMA) in the basal plate of the placenta. Multifocal infarcts and/or multifocal villous clumps were more frequently observed in early onset severe preeclampsia (EOSPE; n=20) ...
Emilsson Louise - - 2013
Patients with coeliac disease and myocardial infarction have a more favourable atherosclerotic risk factor profile than controls with myocardial infarction (MI). Therefore, MI prognosis and treatment may differ according to coeliac status. Study of Swedish MI patients with and without coeliac disease (equal to villous atrophy; Marsh histopathology stage 3) ...
Guay Joanne - - 2013
To determine major adverse outcomes, including the risk of mediastinal reexploration, death, stroke and myocardial infarction, associated with continuing antiplatelet therapy in patients undergoing surgery with cardiopulmonary bypass. A meta-analysis of parallel randomized, controlled trials published in English. A university-based electronic search. Patients undergoing surgery with cardiopulmonary bypass (CPB). Continuing ...
Casalini Eli D - - 2013
This study examined the mechanisms by which H2 S modulates coronary microvascular resistance and myocardial perfusion at rest and in response to cardiac ischemia. Experiments were conducted in isolated coronary arteries and in open-chest anesthetized dogs. We found that the H2 S substrate L-cysteine (1-10 mM) did not alter coronary ...
Ozdemir Semra - - 2013
Fragmented QRS (fQRS) complex is an ECG parameter that has recently been introduced and investigated. It is assumed that fQRS occurs because of disruptions in ventricular conduction due to ventricular infarction and ischemia. Therefore, in this article, we aimed to investigate the relationship between the detection of infarction and ischemia ...
Rienstra Michiel - - 2013
In the last few years, there has been a major shift in the treatment of atrial fibrillation (AF) in the setting of hear failure (HF), from rhythm to ventricular rate control in most patients with both conditions. In this article, the authors focus on ventricular rate control and discuss the ...
Glukhov Alexey V AV Department of Physiology and Cell Biology, College of Veterinary Medicine, Division of Cardiovascular Medicine, and College of Pharmacy, College of Medicine, Dorothy M. Davis Heart and Lung Research Institute, Ohio State University, Columbus, - - 2013
Reentrant arrhythmias involving the sinoatrial node (SAN), namely SAN reentry, remain one of the most intriguing enigmas of cardiac electrophysiology. The goal of the present study was to elucidate the mechanism of SAN micro-reentry in canine hearts with post-myocardial infarction (MI) structural remodeling. In vivo, Holter monitoring revealed ventricular arrhythmias ...
Thielmann Matthias M Department of Thoracic and Cardiovascular Surgery, Universitätsklinikum Essen, Essen, - - 2013
Remote ischaemic preconditioning has been associated with reduced risk of myocardial injury after coronary artery bypass graft (CABG) surgery. We investigated the safety and efficacy of this procedure. Eligible patients were those scheduled to undergo elective isolated first-time CABG surgery under cold crystalloid cardioplegia and cardiopulmonary bypass at the West-German ...
Jeger Raban V - - 2013
Objectives: To assess independent predictors of stent thrombosis (ST) in an all-comer trial. Methods: This is an observational case-control study based on a retrospective analysis of the Basel Stent Kosten Effektivitäts Trial (BASKET) (n = 826). Patients with ST were compared to controls with regard to baseline parameters. Multivariate models ...
Kelmanson Igor A - - 2013
Exaggerated dispersion of repolarization is likely to play a role in both the initiation and the maintenance of malignant ventricular arrhythmias. It was proposed that the inter-lead QT interval differences within a 12-lead ECG termed 'QT dispersion' might reflect regional differences in myocardial refractoriness, and that this might predict cardiac ...
Elosua Roberto - - 2013
The aims of this study were to analyze the dose-response association between leisure time physical activity (PA) practice and myocardial infarction (MI), considering not only the total amount but also the amount of PA at different levels of intensity, and to determine whether these associations were modified by age. In ...
Aukland Stein M - - 2013
Premature birth may be associated with white matter injury later developing with widening of the ventricles. However, population-based data on normal ventricular size by age are sparse, making the evaluation of possible ventricular dilatation difficult. To present the linear measurements of the ventricular system, to compare these to subjectively assessed ...
Oflaz Serap - - 2013
Cardiac damage is a major complication of anorexia nervosa (AN). The present study evaluated the prevalence of myocardial damage in patients with AN by cardiac magnetic resonance imaging (CMR). This study was cross-sectional and observational. Forty consecutive female patients with a diagnosis of AN and 28 healthy female subjects were ...
Kang Sheng - - 2013
The aim of this study was to investigate the effectiveness and safety of aggressive statin versus moderate statin therapy on patients with saphenous vein grafts (SVGs) in randomized, controlled trials (RCTs). We searched MEDLINE (1980-June 2012), the Cochrane Controlled Trials Register, EMBASE, Science Citation Index, and PubMed (to June 2012), ...
Thompson Richard B - - 2013
-Fabry disease (FD) is an X-linked disorder of lysosomal metabolism affecting multiple organs with cardiac disease being the leading cause of death. Current imaging evaluations of the heart are suboptimal. The goals of the current study were to evaluate the potential of quantitative T1 mapping with CMR as a disease-specific ...
Yonetsu Taishi - - 2013
-The pathophysiologic basis for the association between metabolic syndrome (MetS) and coronary artery disease is not well understood. We sought to characterize coronary plaques in patients with MetS using optical coherence tomography (OCT). -We identified 451 coronary plaques from 171 subjects who underwent OCT imaging in three coronary arteries. Subjects ...
Bhatti Salman K - - 2013
To report and compare the outcomes and survival of patients with abnormal computed tomography-derived coronary artery calcium (CT-CAC) scores undergoing aggressive medical treatment at a cardiac prevention clinic. We conducted a retrospective analysis of 849 patients with intermediate risk based on the Framingham risk score and an abnormal CT-CAC score ...
Heijman Jordi - - 2013
Atrial fibrillation (AF) and heart failure (HF) are common cardiovascular pathologies with severe prognostic implications that show bidirectional interactions. Rate and rhythm control are the main therapeutic strategies for patients with AF and HF. There is a paucity of safe and effective antiarrhythmic drugs for rhythm control of AF in ...
Magalotti Selena S Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, - - 2013
Ischemia-related processes associated with the generation of inflammatory molecules such as reactive oxygen species (ROS) are difficult to detect at the acute stage before the physiologic and anatomic evidence of tissue damage is present. Evaluation of the inflammatory and healing response early after an ischemic event in vivo will aid ...
Sangaralingham S Jeson SJ Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, - - 2013
B-type natriuretic peptide (BNP) is a hormone with pleiotropic cardioprotective properties. Previously in our non-placebo-controlled non-blinded pilot study (BELIEVE) in human ST-segment-elevation anterior acute myocardial infarction (AMI), a 72-hour intravenous (IV) infusion of recombinant human BNP (nesiritide) at a dose of 0.006 μg kg(-1) min(-1) suppressed plasma aldosterone, reduced cardiac ...
Mazzone Carmine - - 2013
Limited information is available on left atrial (LA) work in chronic heart failure (CHF) patients. We evaluated correlates and prognostic role of LA work in 243 CHF patients using as reference for normal LA work values 230 healthy controls. Left atrial work was assessed by computation of LA kinetic energy ...
Kirchhof Paulus - - 2013
Even on optimal therapy including anticoagulation and rate control, major cardiovascular complications (stroke, cardiovascular death, and acute heart failure) are common in patients with atrial fibrillation (AF). Conceptually, maintenance of sinus rhythm could prevent adverse outcomes related to AF. Rhythm control therapy has been only moderately effective in published trials, ...
Hinkel Rabea - - 2013
MicroRNAs (miRs) are small non-coding RNAs that posttranscriptionally control gene expression. Small animal studies suggest that miRs might offer novel therapeutic targets in cardiovascular disease, such as cardioprotection of murine hearts after myocardial infarction via miR-92a inhibitors. Since the functional benefits of miR-92a inhibitors in larger pre-clinical models are not ...
Khan Muhammad A - - 2013
Heart failure (HF) and atrial fibrillation (AF) frequently coexist and have emerged as major cardiovascular epidemics. There is growing evidence that AF is an independent prognostic marker in HF and affects patients with both reduced as well as preserved LV systolic function. There has been a general move in clinical ...
Ajijola Olujimi A - - 2013
Background Myocardial infarction (MI) induces neural and electrical remodeling at the scar border zones. The impact of focal MI on global functional neural remodeling is not well understood. Methods and Results Sympathetic stimulation (SS) was performed in swine with antero-apical infarcts (MI) (n=9), and controls (n=9). A 56-electrode sock was ...
Garcia Rodriguez L A - - 2013
Some pharmacokinetic studies have reported that proton pump inhibitors (PPIs) reduce the activity of clopidogrel, but the results of studies assessing clinical outcomes in patients receiving both drugs are inconsistent. We have therefore carried out a population-based cohort study with nested case-control analysis, in order to evaluate changes in the ...
Rufaihah Abdul Jalil - - 2013
Most tissue engineering therapies require biomaterials that are able to induce an angiogenic response to support tissue regeneration. In addition angiogenic growth factor signaling plays an essential role in controlling the process of angiogenesis and matrices have the potential of regulating the concentration of growth factors within the cellular microenvironment. ...
Marfella Raffaele - - 2013
We examined the effects of peri-procedural intensive glycemic control during early percutaneous coronary intervention (PCI) on the number and differentiation of endothelial progenitor cells (EPCs) and myocardial salvage (MS) in hyperglycemic patients with first ST-elevation myocardial infarction (STEMI). We conducted a randomized, prospective, open label study on 194 patients with ...
Alasady Muayad - - 2013
-Myocardial infarction (MI) is associated with the development of atrial fibrillation (AF). We aimed to characterize the atrial abnormalities due to MI and determine the role of ischemia to the AF substrate. Method and Results-Forty-four sheep were studied. MI was induced by occlusion of the circumflex artery (LCX) or left ...
Schmidt Michael R - - 2013
Remote ischemic preconditioning (rIPC) reduces myocardial injury in adults and children undergoing cardiac surgery. We compared the effect of rIPC in adult and neonatal rabbits to investigate whether protection against ischemia-reperfusion injury can be achieved in the newborn heart by (1) in vivo rIPC and (2) dialysate from adult rabbits undergoing ...
Madder Ryan D RD Frederik Meijer Heart and Vascular Institute, Spectrum Health, Grand Rapids, Michigan 49503, USA. - - 2013
This study sought to describe near-infrared spectroscopy (NIRS) findings of culprit lesions in ST-segment elevation myocardial infarction (STEMI). Although autopsy studies demonstrate that most STEMI are caused by rupture of pre-existing lipid core plaque (LCP), it has not been possible to identify LCP in vivo. A novel intracoronary NIRS catheter ...
Sutter M E - - 2013
Abstract Background. Methamphetamine (METH) has been associated with a dilated cardiomyopathy. The first and rate-limiting step of metabolism is dependent on the polymorphic enzyme CYP2D6. Objectives. To evaluate if polymorphisms in CYP2D6 can be associated with the development of a methamphetamine-induced cardiomyopathy. Methods. We performed a prospective case-control pilot study. ...
Wensley Isaac - - 2013
Obesity and its co-morbidities (dyslipidaemia, insulin resistance and hypertension) that together constitute the metabolic syndrome (MetS) are all risk factors for ischaemic heart disease (IHD). Although obesity has been reported to be an independent risk factor for congestive heart failure (CHF), whether obesity induced heart failure develops in the absence ...
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