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Rodrigo Ramón - - 2014
Acute myocardial infarction (AMI) is the leading cause of mortality worldwide. Oxidative stress has been involved in the ischemia-reperfusion injury in AMI. It has been suggested that reperfusion accounts for up to 50% of the final size of a myocardial infarct, a part of the damage likely to be prevented.Therefore, ...
Lipkova Jolana J Institute of Pathological Physiology, Faculty of Medicine, Masaryk University , Czech Republic - - 2014
It is well established that the incidence and infarct size in acute myocardial infarction (AMI) is subject to circadian variations. At the molecular level, circadian clocks in distinct cells, including cardiomyocytes, generate 24-h cycles of biochemical processes. Possible imbalance or impairment in the cell clock mechanism may alter the cardiac ...
Nakamura Akihiro A Department of Child Health, Graduate School of Comprehensive Human Sciences, University of - - 2014
Background:The aim of the present study was to assess the impact of pulmonary regurgitation (PR) and right ventricle (RV) volume on left ventricle (LV) longitudinal strain (LS) in patients with surgically repaired tetralogy of Fallot (r-TOF).Methods and Results:The study subjects were 32 adolescent asymptomatic r-TOF subjects and 30 adolescent healthy controls. Two-dimensional ...
Goldstein David S DS Clinical Neurocardiology Section, CNP/DIR/NINDS/NIH, 20892-1620, Bethesda, - - 2014
In Parkinson disease (PD), profound putamen dopamine (DA) depletion reflects denervation and a shift from vesicular sequestration to oxidative deamination of cytoplasmic DA in residual terminals. PD also involves cardiac sympathetic denervation. Whether PD entails myocardial norepinephrine (NE) depletion and a sequestration-deamination shift have been unknown. We measured apical myocardial ...
Ozkurt Yalçın - - 2014
There are conflicting results about the role of strict rate control on cardiovascular outcomes in patients with chronic atrial fibrillation (AF). So far, large clinical studies did not show a net clinical benefit that the current trend is to specify the target ventricular rate according to the patients'own clinical and ...
Holfeld Johannes J Department of Cardiac Surgery, Innsbruck Medical University, - - 2014
Previously we have shown that epicardial shock-wave therapy improves left ventricular ejection fraction (LVEF) in a rat model of myocardial infarction. In the present experiments we aimed to address the safety and efficacy of epicardial shock-wave therapy in a preclinical large animal model and to further evaluate mechanisms of action ...
Dragulescu Andreea A Division of Cardiology, Labatt Family Heart Centre, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, - - 2014
Right ventricular (RV) volume overload results in RV dilatation and dysfunction in patients with pulmonary regurgitation after tetralogy of Fallot (ToF) repair, affecting left ventricular (LV) function because of ventricular interaction. The aim of this study was to assess the effect of chronic RV volume loading on LV myocardial mechanics ...
Christiansen Jon R JR Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Department of Internal Medicine, Elverum Innlandet Hospital Trust, Elverum, Norway. Electronic address: - - 2014
Survivors of childhood lymphoma (CL) have markedly increased risk of developing heart failure. Echocardiographic studies after cardiotoxic treatment have primarily demonstrated left ventricular (LV) systolic dysfunction. In the present study, we hypothesized that longer follow-up and a more comprehensive echocardiographic examination would reveal more cardiac abnormalities. We conducted a cross-sectional ...
Lou Qing Q The Ohio State University Wexner Medical Center, Columbus, - - 2014
-While sinoatrial node (SAN) dysfunction is a hallmark of human heart failure (HF), the underlying mechanisms remain poorly understood. We aimed to examine the role of adenosine in SAN dysfunction and tachy-brady arrhythmias in chronic HF. -We applied multiple approaches to characterize SAN structure, function and adenosine A1 receptor (A1R) ...
Altin Cihan C Department of Cardiology, The University of Baskent, Ankara, - - 2014
Paclitaxel and carboplatin are frequently used chemotherapy drugs in the treatment of gynecologic malignancies. Little is known about their effects on left ventricular mechanical and coronary microvascular functions. Thirty consecutive patients were prospectively enrolled. Patients underwent transthoracic echocardiography (TTE) before and after chemotherapy, to evaluate left ventricular mechanical functions and ...
Swyer Tw T Sarver Heart Center, College of Medicine, The University of Arizona, Tucson, AZ, - - 2014
Currently there are no medications that can be administered to help deliver more oxygen to the myocardial region experiencing abnormal perfusion. The purpose of this study was to look at the nanoparticle dodecafluoropentane in an emulsion as an oxygen carrier. Using nanoparticles as an oxygen carrier is advantageous because they ...
Emanuele Enzo E Department of Health Sciences, University of Pavia, Pavia, Italy. Electronic address: - - 2014
Skeletal muscles produce irisin. Growing controversy exists on the association between this myokine and chronic disease risk. Based on the potential protective effects that irisin could exert both on vascular function and skeletal muscle mass, we hypothesized that an elevated level of this molecule may contribute to successful aging. Serum ...
Hui Wei W 1Division of Pediatric Cardiology, The Labatt Family Heart Center, Hospital for Sick Children and University of Toronto, Toronto, - - 2014
-Right bundle branch block (RBBB) and right ventricular (RV) dysfunction are common after Tetralogy of Fallot repair (rTOF). We hypothesized that RBBB is associated with specific RV mechanical dyssynchrony and inefficient contraction. -We studied rTOF children and age-matched controls. QRS duration and morphology were assessed. RV mechanical dyssynchrony, indicated by ...
Becatti Matteo M From the Department of Experimental and Clinical Biomedical Sciences (M.B., G.B., N.T., C.F.), Department of Clinical and Experimental Medicine (R.M., A.M.G., B.G., G.F.G., R.A.), and Research Unit of Histology and Embryology, Department of Clinical and Experimental Medicine (D.B.), University of Florence, Florence, Italy; and Don Carlo Gnocchi Foundation, Florence, Italy (A.M.G., - - 2014
Among plasma proteins, fibrinogen represents a major target of oxidative modifications. In patients with post-acute myocardial infarction (6 months after the acute event), fibrinogen oxidation-induced carbonyls and fibrinogen function were estimated using in vitro and ex vivo approaches. Fibrinogen structural features and clot architecture were also explored. In 39 patients ...
Mozid Abdul A Department of Cardiology, London Chest Hospital, Barts Health Trust, London, E2 9JX, - - 2014
Aim: This study presents an interim safety and feasibility analysis of the REGENERATE-IHD randomized controlled trial, which is examining the safety and efficacy of three different delivery routes of bone marrow-derived stem cells (BMSCs) in patients with ischemic heart failure. Methods & results: The first 58 patients recruited to the ...
Noori Noor Mohammad NM Children and Adolescents' Health Research Center, Zahedan University of Medical Sciences, Zahedan, IR - - 2014
In electrocardiography (ECG), QT is the interval between the onset of Q wave to the end of the T wave. This interval may be a sign of changes in the ventricular structure in hematologic disorders such as thalassemia major. The main goal of this study was to compare the diagnostic ...
Kelly-Laubscher R F RF Hatter Institute for Cardiovascular Research in Africa, Chris Barnard Building, Medical School Campus, University of Cape Town, Cape Town, South - - 2014
Sphingosine-1-phosphate (S1P) is a cardioprotective agent. Signal transducer and activator of transcription 3 (STAT-3) is a key mediator of many cardioprotective agents. We aimed to explore whether STAT-3 is a key mediator in S1P-induced preconditioning. Langendorff-perfused hearts from Wistar rats and wild-type or cardiomyocyte-specific STAT-3 knockout mice were pre-treated with ...
Nielsen Trine Skov TS Department of Clinical Medicine, Centre for Clinical Research, Vendsyssel Hospital, Aalborg University, Bispensgade 37, 9800, Hjørring, Denmark, - - 2014
Multiple viruses have been detected in cardiac tissue, but their role in causing myocarditis remains controversial. Viral diagnostics are increasingly used in forensic medicine, but the interpretation of the results can sometimes be challenging. In this study, we examined the prevalence of adenovirus, enterovirus, and parvovirus B19 (PVB) in myocardial ...
Reinier Kyndaron K The Heart Institute, Cedars-Sinai Medical Center, Los Angeles, - - 2014
The purpose of this study was to evaluate the role of congestive heart failure (CHF) in the association between atrial fibrillation (AF) and sudden cardiac death (SCD). Recent studies have reported the possibility of an independent association between AF and SCD. We hypothesized that a history of CHF is a significant ...
Mahmod Masliza - - 2014
Left ventricular (LV) hypertrophy in aortic stenosis (AS) is characterized by reduced myocardial perfusion reserve due to coronary microvascular dysfunction. However, whether this hypoperfusion leads to tissue deoxygenation is unknown. We aimed to assess myocardial oxygenation in severe AS without obstructive coronary artery disease, and to investigate its association with ...
Boriani Giuseppe G Institute of Cardiology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, S.Orsola-Malpighi University Hospital, Via Massarenti 9, 40138 Bologna, - - 2014
Atrial fibrillation (AF) is a common comorbidity in bradycardia patients. Advanced pacemakers feature atrial preventive pacing and atrial antitachycardia pacing (DDDRP) and managed ventricular pacing (MVP), which minimizes unnecessary right ventricular pacing. We evaluated whether DDDRP and MVP might reduce mortality, morbidity, or progression to permanent AF when compared with ...
Mozid Abdul M AM aDepartment of Cardiology, The London Chest Hospital bInstitute of Nuclear Medicine, University College London Hospital cBritish Heart Foundation Laboratories, University College London, London, UK dSection of Cardiovascular Medicine, School of Medicine, Yale University, New Haven, Connecticut, USA eDepartment of Nuclear Medicine, Karolinska University Hospital, Huddinge, Sweden fCentre for Medical Radiation Physics, University of Wollongong, Wollongong, New South Wales, - - 2014
Bone marrow stem cell (BMSC) therapy for cardiovascular disease has shown considerable preclinical and clinical promise, but there remains a need for mechanistic studies to help bridge the transition from bench to bedside. We have designed a substudy to our REGENERATE-IHD trial (ClinicalTrial.gov Identifier: NCT00747708) to assess the feasibility of ...
Ouellette Daniel R - - 2014
The aim of this study was to determine if there are differences between patients with pre-existing left ventricular dysfunction and those with normal antecedent left ventricular function during a sepsis episode in terms of in-hospital mortality and mortality risk factors when treated in accordance with a sepsis treatment algorithm. We ...
Gong B B State Key Laboratory of Cardiovascular Medicine, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, - - 2014
Microplegia (whole blood cardioplegia with reduced volume) retains all the advantages of blood cardioplegia (such as superior oxygen-carrying capacity, better osmotic properties and antioxidant capability, etc.) without the potential disadvantages of hemodilution (such as myocardial edema). We sought to perform a systematic review and meta-analysis to compare microplegia and standard ...
Asp Anna M AM Department of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, - - 2014
Left ventricular (LV) hypertrophy (LVH) and reduced LV function correlate with poor prognosis in patients with chronic kidney disease (CKD). Our aim is to investigate whether mild-to-moderate CKD is associated with cardiac abnormalities. Echocardiography, including tissue Doppler imaging, was performed in 103 patients with CKD at stages 2-3 and 4-5, ...
Alsamara Mershed M Cardiovascular Division, Heart Institute, Providence Hospitals and medical Center 16001 West 9 mile road, Southfield, MI 48075, - - 2014
Heart failure with preserved ejection fraction accounts for up to 50% of hospitalized heart failure patients and is associated with significant mortality and morbidity. The pathophysiology is heterogeneous and not very well defined, which explains the lack of disease-specific therapies. The principles of treating heart failure with preserved ejection fraction ...
Friedman Kevin G KG Department of Cardiology, Children's Hospital Boston, Boston Massachusetts; Department of Pediatrics, Harvard Medical School, Boston Massachusetts. Electronic address: - - 2014
Fetal aortic balloon valvuloplasty (FAV) has shown promise in averting progression of midgestation aortic stenosis (AS) to hypoplastic left heart syndrome in a subset of patients. Patients who achieve biventricular circulation after FAV frequently have left ventricular (LV) diastolic dysfunction (DD). This study evaluates DD in fetuses with AS by ...
Yang Hsin-Jung HJ From the Biomedical Imaging Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, 8700 Beverly Blvd, PACT Building, Suite 800, Los Angeles, CA 90048 (H.J.Y., R.T., I.C., A.K., B.S., D.L., R.D.); Departments of Bioengineering (H.J.Y., A.K., D.L.), Anesthesiology (R.Y.), and Medicine (D.L., R.D.), University of California, Los Angeles, Calif; Department of Physiology (O.S., M.K., J.A.F.) and Department of Anesthesiology, University Health Network (J.A.F.), University of Toronto, Toronto, Ontario, Canada; IMT Institute for Advanced Studies Lucca, Lucca, Italy (S.A.T.); Siemens Medical Solutions USA, Chicago, Ill (X.B.); and Department of Anesthesiology (R.Y., J.T., A.H.C.) and Cedars-Sinai Heart Institute (R.D.), Cedars-Sinai Medical Center, Los Angeles, - - 2014
Purpose To examine whether controlled and tolerable levels of hypercapnia may be an alternative to adenosine, a routinely used coronary vasodilator, in healthy human subjects and animals. Materials and Methods Human studies were approved by the institutional review board and were HIPAA compliant. Eighteen subjects had end-tidal partial pressure of ...
Shah Neeraj N Staten Island University Hospital, Staten Island, NY, United - - 2014
Atrial fibrillation (AF) patients with left ventricular hypertrophy (LVH) and diastolic dysfunction may derive benefit from being in sinus rhythm but no data are available to support this strategy in them. We sought to investigate effect of left ventricular remodeling on cardiovascular outcomes in AF patients undergoing rhythm control strategy. ...
Yu Hou-You HY Department of Emergency Medicine, Xijing hospital, Fourth Military Medical University, No.17 Changle West Road, Xi'an, 710032, P.R. - - 2014
Adropin is a recently identified bioactive protein that is important for energy homeostasis and maintaining insulin sensitivity. We sought to detect serum adropin levels in acute myocardial infarction (AMI) patients. We enrolled 138 AMI patients, 114 stable angina pectoris (SAP) patients and 75 controls. Adropin levels were measured by enzyme-linked ...
Liu Yuting Y 1 The Second Affiliated Hospital of Harbin Medical University , Harbin, China - - 2014
Abstract Objective: To analyze changes in cardiac function indices after electroacupuncture (EA) at the pericardium 6 (PC-6) acupoint using the equilibrium radionuclide angiocardiography (ERNA) quantity analysis technique. Design: Analysis of clinical outcomes after EA at PC-6 measured by ERNA. Setting: The study was conducted in a hospital. Participants: 31 participants ...
Al Ali Juwairia J Division of Cardiology, McGill University Health Center, Montreal, Quebec, - - 2014
We sought to compare the efficacy of coronary artery bypass graft surgery (CABG) to that of percutaneous coronary intervention (PCI) with first-generation drug-eluting stents among patients with multivessel disease (MVD), unprotected left main (LM) disease, and single-vessel proximal left anterior descending (LAD) disease. The efficacy and safety of CABG versus ...
Nishii Tatsuya T Department of Radiology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, - - 2014
Myocardial edema and inflammation play an important role in dilated cardiomyopathy (DCM). This pathologic condition can be identified noninvasively using cardiovascular magnetic resonance imaging (CMR). The purpose of this study was to determine the effectiveness of T2 values obtained with T2 mapping in the detection of edema in DCM patients, ...
Zeng Jinming J Department of Anesthesia of Cardiovascular Institute, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi. Electronic address: - - 2014
The purpose of this article was to systematically review randomized controlled trials in which cold blood cardioplegia was compared with cold crystalloid cardioplegia for cardiac surgery. Correlation studies were searched independently in the EMBASE, MEDLINE and Cochrane library databases. The primary endpoints of interest were spontaneous sinus rhythm (SSR) after ...
McDermott Mary M MM Department of Medicine, Northwestern University Feinberg School of Medicine; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine. Electronic address: - - 2014
Basic research suggests that rapid increases in circulating inflammatory and hemostatic blood markers may trigger or indicate impending plaque rupture and coronary thrombosis, resulting in acute ischemic heart disease (IHD) events. However, these associations are not established in humans. The Biomarker Risk Assessment in Vulnerable Outpatients (BRAVO) Study will determine ...
Rambihar Sherryn S Division of Cardiology, University of Toronto, Toronto, Ontario, - - 2014
The submitral apparatus maintains annular-papillary continuity and myocardial geometry. In mitral valve prolapse (MVP), elongated chords and redundant leaflets can interact at the region of myocardial attachment, leading to apparent discordant motion of the basal inferolateral wall. The aim of this study was to test the hypothesis that basal inferolateral ...
Masaki Mitsuru M Cardiovascular Division, Department of Internal Medicine, Hyogo College of - - 2014
Background: Thyroid hormone is associated with arterial stiffness and left ventricular diastolic function in hypothyroid disease. The relationship of thyroid hormone level to cardio-ankle vascular index (CAVI) and left ventricular diastolic function, however, remains unclear in subjects with subclinical hypothyroidism. Methods and Results: We conducted a cross-sectional study of 83 patients with ...
Visser Marlieke M Departments of Surgery (MV, WW, and PAMvL), Clinical Chemistry (MD and TT), and Epidemiology and Biostatistics (MAJ), VU University Medical Center, Amsterdam, Netherlands, and the Departments of Cardio-thoracic Surgery (MV, RC, and BAJMdM), Nuclear Medicine (HJV), Cardiology (WEMK), and Pharmacy (EMK) and the Intensive Care Unit (RT), Academic Medical Center University of Amsterdam, Amsterdam, - - 2014
Nitric oxide (NO) is essential for the optimal perfusion of the heart and its vasculature. NO may be insufficient in surgical patients because its precursor arginine is decreased, and the inhibitor of NO synthesis asymmetric dimethylarginine (ADMA) is increased. Besides arginine, the presence of other amino acids essential for the ...
Liu Daliang D Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. - - 2014
The aim of the present study was to investigate the predictive value of multi-detector computed tomography angiography (MDCTA) on acute coronary artery events in patients with type 2 diabetes mellitus (T2DM). MDCTA was performed in 150 patients with T2DM (males, 74; mean age, 66±6.7 years for all patients) that had ...
Zografos Theodoros A TA First Department of Cardiology, Athens Red Cross Hospital, Athens, Greece; Department of Cardiology, Athens Euroclinic, Athens, - - 2014
Up to 1/3 of percutaneous coronary interventions (PCIs) are complicated by troponin release. Remote ischemic preconditioning (IPC) confers effective cardioprotection; however, a 30-minute remote IPC protocol may be difficult to implement during ad hoc PCI. This study was performed to assess the ability of a brief remote IPC protocol to ...
Shrikhande Sunanda N SN Associate Professor, Department of Microbiology, Indira Gandhi Government Medical College, Nagpur, Maharashtra, - - 2014
Background: Coronary heart disease is multi-factorial in origin and its burden is expected to rise in developing countries, including India. Evidence suggests that the inflammation caused by infection is associated with the development of atherosclerosis and heart disease. An increasing number of clinical and experimental studies point to a contribution ...
Distelmaier Klaus - - 2014
Background & objectives: Atrial fibrillation (AF) is a common complication after acute myocardial infarction (AMI) and associated with increased morbidity and mortality. Previous studies identified high white and red blood cell count as potential risk factors for new onset AF. The objective of this retrospective, nested case-control study was to ...
Male Shailesh - - 2014
Atrial-fibrillation (AF) is the most common clinically encountered arrhythmia affecting over 1 per cent of population in the United States and its prevalence seems to be moving only in forward direction. A recent systemic review estimates global prevalence of AF to be 596.2 and 373.1 per 100,000 population in males ...
Ozdemir Didem D Department of Endocrinology and Metabolism, Ataturk Education and Research Hospital, Yildirim Beyazit University, Ankara, Turkey, - - 2014
Cardiovascular morbidity and mortality are increased in patients with primary hyperparathyroidism (PHPT). We aimed to evaluate left ventricle systolic and diastolic functions with tissue Doppler imaging (TDI) and strain and strain rate echocardiography in patients with PHPT. Thirty-one patients with PHPT and 29 healthy controls were evaluated with conventional and ...
Desai Ankit A AA 1Department of Medicine, University of Illinois Hospitals and Health Sciences System, Chicago, - - 2014
-Cardiovascular disease is an important cause of morbidity and mortality in sickle cell disease (SCD). We sought to characterize sickle cell cardiomyopathy using multi-modality non-invasive cardiovascular testing and identify potential causative mechanisms. -Stable adults with SCD (n=38) and healthy controls (n=13) prospectively underwent same day multi-parametric cardiovascular magnetic resonance (cine, ...
Taşolar Hakan H Adiyaman University, Training and Research Hospital, Department of Cardiology, Adiyaman, Turkey. Electronic address: - - 2014
Smoking may lead to ventricular arrhythmias and sudden cardiac death via altering ventricular recovery time dispersion indices such as QT interval and QT dispersion (QTd). The Tp-e/QT and Tp-e/QTc ratios are also known as predictors of ventricular arrhythmogenesis. The aim of this study was to evaluate the relationship between cigarette ...
Pizarro Gonzalo G Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain; Hospital Universitario Quirón-Universidad Europea de Madrid, - - 2014
To study the long-term effects of i.v. metoprolol administration before reperfusion on left ventricular (LV) function and clinical events. Early i.v. metoprolol during ST-segment elevation myocardial infarction (STEMI) has been shown to reduce infarct size when used in conjunction with primary percutaneous coronary intervention (pPCI). The METOCARD-CNIC trial recruited 270 ...
Nagata Hazumu H Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka City, 812-8582, Japan, - - 2014
Pathologic studies of the heart in patients with Kawasaki disease (KD) revealed vasculitis, valvulitis, myocarditis, and pericarditis. However, there have been no studies on the quantitative determination of multi-site echogenicity of the heart in KD patients. It is also undetermined whether the degree of echogenicity of each site of the ...
Zhang Jing J 1Department of Cardiovascular Medicine, the First Affiliated Hospital, and the Ministry of Health Key Laboratory of Assisted Circulation, Sun Yat-Sen University, Guangzhou, China, and 2 Department of Ultrasonography, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, - - 2014
To investigate the effects and mechanisms of nardostachys chinensis on spontaneous ventricular arrhythmias in rats with hyper-acute myocardial infarction (AMI). Seventy-two rats were randomly divided into the control group (n=24), metoprolol group (n=24) and the NC group (n=24). Premature ventricular contractions (PVCs), ventricular tachycardias (VTs), ventricular fibrillations (VFs) and blood ...
Duchateau Nicolas N Arrythmia, Resynchronization and Cardiac Imaging Unit, Hospital Clínic, Universitat de Barcelona, Calle Villaroel 170, 08036, Barcelona, Spain, - - 2014
In cardiac resynchronization therapy (CRT), specific changes in motion/deformation happen with left-bundle-branch-block (LBBB) and following treatment. However, they remain sub-optimally studied. We propose a two-fold improvement of their characterization. This includes controlling them through an experimental model and using more suitable quantification techniques. We used a swine model of acute ...
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