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Martinez C - - 2014
It was the aim of this study to determine prognosis of incidentally detected ambulatory atrial fibrillation (IA-AF) and its response to antithrombotic therapy. We performed a cohort study of 5,555 patients with IA-AF (mean age 70.9 ± 10.1, 38.4% female) and 24,705 age- and gender-matched controls without AF followed three ...
Lipkova Jolana J Faculty of Medicine, Institute of Pathological Physiology, Masaryk University, Kamenice 753/5, 625 00, Brno, Czech - - 2014
Chemokines, including RANTES, play a crucial role in the processes of inflammation during cardiovascular disorders, including myocardial infarction, disease progression and complications. This study aimed to evaluate the role of RANTES -403G/A polymorphism and levels in circulation in processes of development and progression of myocardial infarction and cardiogenic shock. A ...
Gazi Emine E Department of Cardiology, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, - - 2014
Objective: To investigate intercellular adhesion molecule-1 (ICAM1) and angiotensinogen (AGT) gene polymorphisms, as related to atherosclerosis and endothelial dysfunction, in coronary slow flow (CSF). Subjects and Methods: The participants in this study were 48 patients with CSF and 67 patients with normal coronary flow as controls. The K469E polymorphism of ...
Deng Yan Y Department of Ultrasound, The First Affiliated Hospital of Guangxi Medical University, Nanning, - - 2014
This study evaluated the feasibility of assessing left atrium (LA) function and asynchrony in patients with rheumatic mitral stenosis (MS) before and immediately after percutaneous balloon mitral valvuloplasty (PBMV) by real time three-dimensional echocardiography (RT3DE). Thirty patients with rheumatic MS who underwent PBMV and 30 controls were enrolled. RT3DE was ...
Hwang Hyosook H From the Department of Nuclear Medicine, Molecular Imaging and Therapeutic Medicine Research Center, Cyclotron Research Center, Institute for Medical Sciences, and Biomedical Research Institute, Chonbuk National University Medical School and Hospital, 634-18 GeumAm-dong Duckjin-gu Jeonju-si, Jeollabuk-do 561-803, South Korea (H.H., J.K., P.S.O., T.K.L., K.S.N., H.S.J., S.T.L., M.H.S., H.J.J.); and Department of Biomedical Engineering, Chonnam National University, Yeosu, South Korea - - 2014
Purpose To determine whether chitosan hydrogel nanoparticles loaded with vascular endothelial growth factor (VEGF) peptides (81-91 fragments) capable of targeting the ischemic myocardium enhance angiogenesis and promote therapeutic effects and whether radionuclide image-guided dosage control is feasible. Materials and Methods Experimental procedures and protocols were approved by the Institutional Animal ...
Liu Xiao-Yan XY aCenter for Arrhythmia Diagnosis and Treatment, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China bSchool of Biomedical Sciences, Charles Sturt University, Wagga Wagga, New South Wales, - - 2014
The variation of the substrates of verapamil-sensitive idiopathic left ventricular tachycardia (ILVT) was not understood. The purpose of this study was to investigate the variation of electroanatomic substrate [slow conduction zone (SCZ) and left ventricular conduction system (LVCS)] in ILVT and control individuals and markers of successful ablation. Electroanatomical mapping ...
Agati L L Department of Cardiology, 'Sapienza' University, Viale del Policlinico 155, Roma 00161, Italy - - 2014
Left ventricular (LV) diastolic filling is characterized by the formation of a vortex that supports an efficient transit into systolic ejection. Aim of this study was to assess the intraventricular (IV) blood flow dynamics among patients with ST elevated myocardial infarction (STEMI) at different degrees of LV dysfunction, in the ...
Patel Neil N Sullivan University College of Pharmacy , Louisville, KY , USA - - 2014
Abstract Background: Increased NF-κB levels play a crucial role in the pathophysiology of heart failure and are known to cause ventricular remodeling. Antisense therapy can be used for blocking the expression of NF-κB and subsequently avoiding heart failure. However, as with most biotechnology products, molecular instability and overall cost are ...
Graça Bruno B 1 Faculty of Medicine, University of Coimbra, Azinhaga de Santa Comba, 3000-548, Coimbra, - - 2014
OBJECTIVE. The purpose of this study was to compare cardiac MRI-derived parameters of left ventricular (LV) diastolic function between uncomplicated type 2 diabetes mellitus (DM2) and normoglycemic control subjects and to evaluate whether these parameters of LV diastolic function are related to coronary atherosclerosis. SUBJECTS AND METHODS. We prospectively studied ...
Liu Liwen L Department of Ultrasound, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. - - 2014
The early detection of abnormal left ventricular systolic functions in patients with hypertrophic cardiomyopathy (HCM) remains a challenge. The aim of this study was to identify a novel method for the assessment of left ventricular systolic function in patients with HCM. A total of 65 patients with HCM were included ...
Schneider Heiko H University of - - 2014
Adults with Tetralogy of Fallot (ToF) have an increased risk of heart failure, arrhythmias and sudden death. We sought to investigate whether myocardial remodelling of the right ventricular outflow tract (RVOT) could be responsible. We collected RVOT myocardial biopsies from 10 ToF patients (6 male) at the time of pulmonary ...
Llewellyn Michael E ME Departments of Radiology (M.E.L., R.B.J., E.W.O.) and Pathology (M.A.D.), Stanford University School of Medicine, Stanford, California USA; and Radiology Service, Veterans Affairs Palo Alto Health Care System, Palo Alto, California USA - - 2014
To evaluate the frequency of the "bright band sign" in patients with splenic infarcts as well as control patients and to thereby assess whether the bright band sign has potential utility as a sonographic sign of splenic infarction. Using an electronic search engine and image review, 37 patients were retrospectively ...
McKeag Nicholas A NA Centre for Public Health, School of Medicine, Dentistry & Biomedical Sciences, Queen's University, Belfast, Northern Ireland; The Heart Centre, Belfast Health & Social Care Trust, Belfast, Northern Ireland. Electronic address: - - 2014
This study sought to investigate the effect of a multiple micronutrient supplement on left ventricular ejection fraction (LVEF) in patients with heart failure. Observational studies suggest that patients with heart failure have reduced intake and lower concentrations of a number of micronutrients. However, there have been very few intervention studies investigating ...
Zhong Yong Y From Jinling Hospital, Department of Cardiology, Nanjing University, School of Medicine , Nanjing , P. R. - - 2014
Background. Myocardial bridging (MB), a common benign coronary anomaly, may bring about some unwanted complications such as angina-like chest pain. The only way of MB detection is coronary arteriography or coronary computed tomographic angiography, which is costly and invasive. This study intended to profile a panel of circulating microRNAs (miRNAs) ...
Melenovsky Vojtech V Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, MN, USA Department of Cardiology, Institute of Clinical and Experimental Medicine - IKEM, Videnska 1958/9, Prague 4 140 28, Czech Republic - - 2014
Right heart function is not well characterized in patients with heart failure and preserved ejection fraction (HFpEF). The goal of this study was to examine the haemodynamic, clinical, and prognostic correlates of right ventricular dysfunction (RVD) in HFpEF. Heart failure and preserved ejection fraction patients (n = 96) and controls ...
Rodrigo Ramón - - 2014
Acute myocardial infarction (AMI) is the leading cause of mortality worldwide. Oxidative stress has been involved in the ischemia-reperfusion injury in AMI. It has been suggested that reperfusion accounts for up to 50% of the final size of a myocardial infarct, a part of the damage likely to be prevented.Therefore, ...
Lipkova Jolana J Institute of Pathological Physiology, Faculty of Medicine, Masaryk University , Czech Republic - - 2014
It is well established that the incidence and infarct size in acute myocardial infarction (AMI) is subject to circadian variations. At the molecular level, circadian clocks in distinct cells, including cardiomyocytes, generate 24-h cycles of biochemical processes. Possible imbalance or impairment in the cell clock mechanism may alter the cardiac ...
Nakamura Akihiro A Department of Child Health, Graduate School of Comprehensive Human Sciences, University of - - 2014
Background:The aim of the present study was to assess the impact of pulmonary regurgitation (PR) and right ventricle (RV) volume on left ventricle (LV) longitudinal strain (LS) in patients with surgically repaired tetralogy of Fallot (r-TOF).Methods and Results:The study subjects were 32 adolescent asymptomatic r-TOF subjects and 30 adolescent healthy controls. Two-dimensional ...
Goldstein David S DS Clinical Neurocardiology Section, CNP/DIR/NINDS/NIH, 20892-1620, Bethesda, - - 2014
In Parkinson disease (PD), profound putamen dopamine (DA) depletion reflects denervation and a shift from vesicular sequestration to oxidative deamination of cytoplasmic DA in residual terminals. PD also involves cardiac sympathetic denervation. Whether PD entails myocardial norepinephrine (NE) depletion and a sequestration-deamination shift have been unknown. We measured apical myocardial ...
Ozkurt Yalçın - - 2014
There are conflicting results about the role of strict rate control on cardiovascular outcomes in patients with chronic atrial fibrillation (AF). So far, large clinical studies did not show a net clinical benefit that the current trend is to specify the target ventricular rate according to the patients'own clinical and ...
Holfeld Johannes J Department of Cardiac Surgery, Innsbruck Medical University, - - 2014
Previously we have shown that epicardial shock-wave therapy improves left ventricular ejection fraction (LVEF) in a rat model of myocardial infarction. In the present experiments we aimed to address the safety and efficacy of epicardial shock-wave therapy in a preclinical large animal model and to further evaluate mechanisms of action ...
Christiansen Jon R JR Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Department of Internal Medicine, Elverum Innlandet Hospital Trust, Elverum, Norway. Electronic address: - - 2014
Survivors of childhood lymphoma (CL) have markedly increased risk of developing heart failure. Echocardiographic studies after cardiotoxic treatment have primarily demonstrated left ventricular (LV) systolic dysfunction. In the present study, we hypothesized that longer follow-up and a more comprehensive echocardiographic examination would reveal more cardiac abnormalities. We conducted a cross-sectional ...
Dragulescu Andreea A Division of Cardiology, Labatt Family Heart Centre, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, - - 2014
Right ventricular (RV) volume overload results in RV dilatation and dysfunction in patients with pulmonary regurgitation after tetralogy of Fallot (ToF) repair, affecting left ventricular (LV) function because of ventricular interaction. The aim of this study was to assess the effect of chronic RV volume loading on LV myocardial mechanics ...
Lou Qing Q The Ohio State University Wexner Medical Center, Columbus, - - 2014
-While sinoatrial node (SAN) dysfunction is a hallmark of human heart failure (HF), the underlying mechanisms remain poorly understood. We aimed to examine the role of adenosine in SAN dysfunction and tachy-brady arrhythmias in chronic HF. -We applied multiple approaches to characterize SAN structure, function and adenosine A1 receptor (A1R) ...
Altin Cihan C Department of Cardiology, The University of Baskent, Ankara, - - 2014
Paclitaxel and carboplatin are frequently used chemotherapy drugs in the treatment of gynecologic malignancies. Little is known about their effects on left ventricular mechanical and coronary microvascular functions. Thirty consecutive patients were prospectively enrolled. Patients underwent transthoracic echocardiography (TTE) before and after chemotherapy, to evaluate left ventricular mechanical functions and ...
Swyer Tw T Sarver Heart Center, College of Medicine, The University of Arizona, Tucson, AZ, - - 2014
Currently there are no medications that can be administered to help deliver more oxygen to the myocardial region experiencing abnormal perfusion. The purpose of this study was to look at the nanoparticle dodecafluoropentane in an emulsion as an oxygen carrier. Using nanoparticles as an oxygen carrier is advantageous because they ...
Emanuele Enzo E Department of Health Sciences, University of Pavia, Pavia, Italy. Electronic address: - - 2014
Skeletal muscles produce irisin. Growing controversy exists on the association between this myokine and chronic disease risk. Based on the potential protective effects that irisin could exert both on vascular function and skeletal muscle mass, we hypothesized that an elevated level of this molecule may contribute to successful aging. Serum ...
Mozid Abdul A Department of Cardiology, London Chest Hospital, Barts Health Trust, London, E2 9JX, - - 2014
Aim: This study presents an interim safety and feasibility analysis of the REGENERATE-IHD randomized controlled trial, which is examining the safety and efficacy of three different delivery routes of bone marrow-derived stem cells (BMSCs) in patients with ischemic heart failure. Methods & results: The first 58 patients recruited to the ...
Noori Noor Mohammad NM Children and Adolescents' Health Research Center, Zahedan University of Medical Sciences, Zahedan, IR - - 2014
In electrocardiography (ECG), QT is the interval between the onset of Q wave to the end of the T wave. This interval may be a sign of changes in the ventricular structure in hematologic disorders such as thalassemia major. The main goal of this study was to compare the diagnostic ...
Becatti Matteo M From the Department of Experimental and Clinical Biomedical Sciences (M.B., G.B., N.T., C.F.), Department of Clinical and Experimental Medicine (R.M., A.M.G., B.G., G.F.G., R.A.), and Research Unit of Histology and Embryology, Department of Clinical and Experimental Medicine (D.B.), University of Florence, Florence, Italy; and Don Carlo Gnocchi Foundation, Florence, Italy (A.M.G., - - 2014
Among plasma proteins, fibrinogen represents a major target of oxidative modifications. In patients with post-acute myocardial infarction (6 months after the acute event), fibrinogen oxidation-induced carbonyls and fibrinogen function were estimated using in vitro and ex vivo approaches. Fibrinogen structural features and clot architecture were also explored. In 39 patients ...
Hui Wei W 1Division of Pediatric Cardiology, The Labatt Family Heart Center, Hospital for Sick Children and University of Toronto, Toronto, - - 2014
-Right bundle branch block (RBBB) and right ventricular (RV) dysfunction are common after Tetralogy of Fallot repair (rTOF). We hypothesized that RBBB is associated with specific RV mechanical dyssynchrony and inefficient contraction. -We studied rTOF children and age-matched controls. QRS duration and morphology were assessed. RV mechanical dyssynchrony, indicated by ...
Kelly-Laubscher R F RF Hatter Institute for Cardiovascular Research in Africa, Chris Barnard Building, Medical School Campus, University of Cape Town, Cape Town, South - - 2014
Sphingosine-1-phosphate (S1P) is a cardioprotective agent. Signal transducer and activator of transcription 3 (STAT-3) is a key mediator of many cardioprotective agents. We aimed to explore whether STAT-3 is a key mediator in S1P-induced preconditioning. Langendorff-perfused hearts from Wistar rats and wild-type or cardiomyocyte-specific STAT-3 knockout mice were pre-treated with ...
Nielsen Trine Skov TS Department of Clinical Medicine, Centre for Clinical Research, Vendsyssel Hospital, Aalborg University, Bispensgade 37, 9800, Hjørring, Denmark, - - 2014
Multiple viruses have been detected in cardiac tissue, but their role in causing myocarditis remains controversial. Viral diagnostics are increasingly used in forensic medicine, but the interpretation of the results can sometimes be challenging. In this study, we examined the prevalence of adenovirus, enterovirus, and parvovirus B19 (PVB) in myocardial ...
Reinier Kyndaron K The Heart Institute, Cedars-Sinai Medical Center, Los Angeles, - - 2014
The purpose of this study was to evaluate the role of congestive heart failure (CHF) in the association between atrial fibrillation (AF) and sudden cardiac death (SCD). Recent studies have reported the possibility of an independent association between AF and SCD. We hypothesized that a history of CHF is a significant ...
Mahmod Masliza - - 2014
Left ventricular (LV) hypertrophy in aortic stenosis (AS) is characterized by reduced myocardial perfusion reserve due to coronary microvascular dysfunction. However, whether this hypoperfusion leads to tissue deoxygenation is unknown. We aimed to assess myocardial oxygenation in severe AS without obstructive coronary artery disease, and to investigate its association with ...
Boriani Giuseppe G Institute of Cardiology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, S.Orsola-Malpighi University Hospital, Via Massarenti 9, 40138 Bologna, - - 2014
Atrial fibrillation (AF) is a common comorbidity in bradycardia patients. Advanced pacemakers feature atrial preventive pacing and atrial antitachycardia pacing (DDDRP) and managed ventricular pacing (MVP), which minimizes unnecessary right ventricular pacing. We evaluated whether DDDRP and MVP might reduce mortality, morbidity, or progression to permanent AF when compared with ...
Mozid Abdul M AM aDepartment of Cardiology, The London Chest Hospital bInstitute of Nuclear Medicine, University College London Hospital cBritish Heart Foundation Laboratories, University College London, London, UK dSection of Cardiovascular Medicine, School of Medicine, Yale University, New Haven, Connecticut, USA eDepartment of Nuclear Medicine, Karolinska University Hospital, Huddinge, Sweden fCentre for Medical Radiation Physics, University of Wollongong, Wollongong, New South Wales, - - 2014
Bone marrow stem cell (BMSC) therapy for cardiovascular disease has shown considerable preclinical and clinical promise, but there remains a need for mechanistic studies to help bridge the transition from bench to bedside. We have designed a substudy to our REGENERATE-IHD trial (ClinicalTrial.gov Identifier: NCT00747708) to assess the feasibility of ...
Ouellette Daniel R - - 2014
The aim of this study was to determine if there are differences between patients with pre-existing left ventricular dysfunction and those with normal antecedent left ventricular function during a sepsis episode in terms of in-hospital mortality and mortality risk factors when treated in accordance with a sepsis treatment algorithm. We ...
Gong B B State Key Laboratory of Cardiovascular Medicine, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, - - 2014
Microplegia (whole blood cardioplegia with reduced volume) retains all the advantages of blood cardioplegia (such as superior oxygen-carrying capacity, better osmotic properties and antioxidant capability, etc.) without the potential disadvantages of hemodilution (such as myocardial edema). We sought to perform a systematic review and meta-analysis to compare microplegia and standard ...
Asp Anna M AM Department of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, - - 2014
Left ventricular (LV) hypertrophy (LVH) and reduced LV function correlate with poor prognosis in patients with chronic kidney disease (CKD). Our aim is to investigate whether mild-to-moderate CKD is associated with cardiac abnormalities. Echocardiography, including tissue Doppler imaging, was performed in 103 patients with CKD at stages 2-3 and 4-5, ...
Alsamara Mershed M Cardiovascular Division, Heart Institute, Providence Hospitals and medical Center 16001 West 9 mile road, Southfield, MI 48075, - - 2014
Heart failure with preserved ejection fraction accounts for up to 50% of hospitalized heart failure patients and is associated with significant mortality and morbidity. The pathophysiology is heterogeneous and not very well defined, which explains the lack of disease-specific therapies. The principles of treating heart failure with preserved ejection fraction ...
Friedman Kevin G KG Department of Cardiology, Children's Hospital Boston, Boston Massachusetts; Department of Pediatrics, Harvard Medical School, Boston Massachusetts. Electronic address: - - 2014
Fetal aortic balloon valvuloplasty (FAV) has shown promise in averting progression of midgestation aortic stenosis (AS) to hypoplastic left heart syndrome in a subset of patients. Patients who achieve biventricular circulation after FAV frequently have left ventricular (LV) diastolic dysfunction (DD). This study evaluates DD in fetuses with AS by ...
Yang Hsin-Jung HJ From the Biomedical Imaging Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, 8700 Beverly Blvd, PACT Building, Suite 800, Los Angeles, CA 90048 (H.J.Y., R.T., I.C., A.K., B.S., D.L., R.D.); Departments of Bioengineering (H.J.Y., A.K., D.L.), Anesthesiology (R.Y.), and Medicine (D.L., R.D.), University of California, Los Angeles, Calif; Department of Physiology (O.S., M.K., J.A.F.) and Department of Anesthesiology, University Health Network (J.A.F.), University of Toronto, Toronto, Ontario, Canada; IMT Institute for Advanced Studies Lucca, Lucca, Italy (S.A.T.); Siemens Medical Solutions USA, Chicago, Ill (X.B.); and Department of Anesthesiology (R.Y., J.T., A.H.C.) and Cedars-Sinai Heart Institute (R.D.), Cedars-Sinai Medical Center, Los Angeles, - - 2014
Purpose To examine whether controlled and tolerable levels of hypercapnia may be an alternative to adenosine, a routinely used coronary vasodilator, in healthy human subjects and animals. Materials and Methods Human studies were approved by the institutional review board and were HIPAA compliant. Eighteen subjects had end-tidal partial pressure of ...
Shah Neeraj N Staten Island University Hospital, Staten Island, NY, United - - 2014
Atrial fibrillation (AF) patients with left ventricular hypertrophy (LVH) and diastolic dysfunction may derive benefit from being in sinus rhythm but no data are available to support this strategy in them. We sought to investigate effect of left ventricular remodeling on cardiovascular outcomes in AF patients undergoing rhythm control strategy. ...
Yu Hou-You HY Department of Emergency Medicine, Xijing hospital, Fourth Military Medical University, No.17 Changle West Road, Xi'an, 710032, P.R. - - 2014
Adropin is a recently identified bioactive protein that is important for energy homeostasis and maintaining insulin sensitivity. We sought to detect serum adropin levels in acute myocardial infarction (AMI) patients. We enrolled 138 AMI patients, 114 stable angina pectoris (SAP) patients and 75 controls. Adropin levels were measured by enzyme-linked ...
Liu Yuting Y 1 The Second Affiliated Hospital of Harbin Medical University , Harbin, China - - 2014
Abstract Objective: To analyze changes in cardiac function indices after electroacupuncture (EA) at the pericardium 6 (PC-6) acupoint using the equilibrium radionuclide angiocardiography (ERNA) quantity analysis technique. Design: Analysis of clinical outcomes after EA at PC-6 measured by ERNA. Setting: The study was conducted in a hospital. Participants: 31 participants ...
Al Ali Juwairia J Division of Cardiology, McGill University Health Center, Montreal, Quebec, - - 2014
We sought to compare the efficacy of coronary artery bypass graft surgery (CABG) to that of percutaneous coronary intervention (PCI) with first-generation drug-eluting stents among patients with multivessel disease (MVD), unprotected left main (LM) disease, and single-vessel proximal left anterior descending (LAD) disease. The efficacy and safety of CABG versus ...
Nishii Tatsuya T Department of Radiology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, - - 2014
Myocardial edema and inflammation play an important role in dilated cardiomyopathy (DCM). This pathologic condition can be identified noninvasively using cardiovascular magnetic resonance imaging (CMR). The purpose of this study was to determine the effectiveness of T2 values obtained with T2 mapping in the detection of edema in DCM patients, ...
McDermott Mary M MM Department of Medicine, Northwestern University Feinberg School of Medicine; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine. Electronic address: - - 2014
Basic research suggests that rapid increases in circulating inflammatory and hemostatic blood markers may trigger or indicate impending plaque rupture and coronary thrombosis, resulting in acute ischemic heart disease (IHD) events. However, these associations are not established in humans. The Biomarker Risk Assessment in Vulnerable Outpatients (BRAVO) Study will determine ...
Zeng Jinming J Department of Anesthesia of Cardiovascular Institute, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi. Electronic address: - - 2014
The purpose of this article was to systematically review randomized controlled trials in which cold blood cardioplegia was compared with cold crystalloid cardioplegia for cardiac surgery. Correlation studies were searched independently in the EMBASE, MEDLINE and Cochrane library databases. The primary endpoints of interest were spontaneous sinus rhythm (SSR) after ...
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