Search Results
Results 451 - 500 of 1317
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Cieplucha Aleksandra - - 2013
Among adults with congenital heart diseases (CHD) evaluation of sudden cardiac death (SCD) risk remains a great challenge. Although microvolt T-wave alternans has been incorporated into SCD risk stratification algorithm, its role in adults with CHD still requires investigation. We sought to determine the incidence of MTWA in this specific ...
Sörensson Peder - - 2013
Ischemic postconditioning (PostC), reperfusion in brief cycles, is known to induce short-term reduction in infarct size in patients with ST elevation myocardial infarction (STEMI), especially among those with large myocardium at risk (MaR). The aim of the present study was to investigate the long-term effect of PostC on infarct size ...
Smid Machiel - - 2013
Thrombin is a key protease in coagulation also implicated in complex pathology including atherosclerosis. To address the role of thrombin in relation to myocardial infarction (MI) we explored thrombin generation analysis in plasma from patients and controls that had participated in the Glasgow MI Study (GLAMIS). Thrombin generation at 1 ...
Wożakowska-Kapłon Beata - - 2013
Periodontitis may contribute to destabilization of atherosclerotic plaque leading to acute coronary syndrome and myocardial infarction (MI). The aim of the paper was to evaluate the state of the oral cavity and test the association between chosen parameters of acute, hospital phase MI in patients aged 60 and younger. We ...
Kemmling André - - 2013
Hospital acquired pneumonia (HAP) is a major complication of stroke. We sought to determine associations between infarction of specific brain regions and HAP. 215 consecutive acute stroke patients with HAP (2003-2009) were carefully matched with 215 non-pneumonia controls by gender, then NIHSS, then age. Admission imaging and binary masks of ...
Faragallah George - - 2013
The use of a rotary Left Ventricular Assist Device (LVAD) as a bridge-to-recovery treatment is gaining considerable attention in the LVAD research community. Using a mathematical model of the cardiovascular-LVAD system, this paper intends to define the critical control parameters in terms of power and rotational speed of the LVAD ...
Schusterova I - - 2013
Objectives: Several studies have found an association between obesity and heart failure. The purpose of our study was to identify the influence of the severity of obesity in children on structural and functional changes of the left ventricle and parameters of the systolic and diastolic function.Methods: This was a prospective ...
Pei Junrui - - 2013
Oxidative stress and selenoprotein deficiency are thought to be associated with the pathogenesis of Keshan disease (KD). However, to our knowledge, the level of oxidative stress and expression of selenoproteins have not been investigated in the myocardium of patients with KD. In this study, 8-hydroxy-2-deoxy guanosine (8-OH-dG), a marker of ...
Dodiyi-Manuel Sotonye T - - 2013
Diabetes mellitus (DM) is on the increase globally. Cardiovascular complications, such as left ventricular dysfunction is a major cause of death in patients with type II DM. Prior to the development of symptomatic heart failure, subclinical left ventricular dysfunction (systolic and diastolic) may exist for some time. The aim of ...
Jamshidi Nahid - - 2013
Coronary angiography is a widely used invasive procedure for diagnosis of coronary artery diseases. The patients benefit from information about an invasive diagnostic procedure. The aim of this study was to evaluate the effects of two educational methods (video information vs. verbal information) on the level of satisfaction, comfort, tolerability ...
Li Shu-Na - - 2013
Altered septal curvature and left ventricular (LV) geometry secondary to right ventricular (RV) dilation render two-dimensional assessment of LV mechanics difficult in repaired tetralogy of Fallot (TOF) patients. The novel three-dimensional (3D) speckle tracking echocardiography enables comprehensive evaluation of true 3D LV mechanics. Seventy-six patients aged 23.6±8.3 years, 55 with ...
Beiras-Fernandez Andres - - 2013
Background Galectins are a family of soluble lectins expressed in a variety of tissues, which play many important regulatory roles in inflammation, immunity, and cancer. The up-regulation of galectin-3 in hypertrophied hearts and the development of fibrosis have been shown in experimental studies. Increased galectin-3 levels are associated with poor ...
Fang Lu - - 2013
Fibrocytes are bone marrow-derived mesenchymal progenitors that have been linked to various fibrotic disorders. This study was undertaken to investigate whether fibrocytes are increased in diffuse myocardial fibrosis in humans. Thirty-seven patients with hypertrophic cardiomyopathy (HCM) and 20 healthy controls were recruited. Cardiac magnetic resonance imaging with postcontrast T1 mapping ...
Chan William - - 2013
Early diagnosis and knowledge of infarct size is critical for the management of acute myocardial infarction (MI). We evaluated whether early elevated plasma level of macrophage migration inhibitory factor (MIF) is useful for these purposes in patients with ST-elevation MI (STEMI). We first studied MIF level in plasma and the ...
Símová J - - 2013
The myocardial extracellular matrix plays an important role in maintaining the structural and functional integrity of the heart and is centrally involved in post-myocardial infarction repair processes. We analysed some genetic and proteomic aspects that could play an important role in the development of myocardial infarction. Matrix metalloproteinases are enzymes ...
Rubio María C - - 2013
There is evidence that acute myocardial infarction (AMI) is associated with increasing production of reactive oxygen species and tissue injury. The aim of this study was to assess the presence of oxidative stress indices in saliva 24 and 48h after AMI. We designed a prospective study comparing salivary levels of ...
Pucci S - - 2013
Fractalkine is a proinflammatory chemokine that participates in atherosclerotic process mediating the interactions of vascular cells and leukocytes and selective recruitment of Th1 lymphocytes, through interaction with CX3CR1 receptor. The polymorphism of the fractalkine receptor 280M-containing haplotype, which codifies for a receptor with minor expression and with a reduced binding ...
El-Mesallamy Hala O - - 2013
Objective. The proapoptotic protein, granzyme B (GZB), was identified as a contributor to the atherosclerotic plaque instability and recently as inflammatory activator. We studied the release kinetics of GZB and other markers of inflammation such as high sensitivity C reactive protein (hsCRP), interleukin 18 (IL-18), and fractalkine (FKN) in the ...
Zigra Aggeliki-Maria AM Laboratory of Haematology and Blood Transfusion Unit, Attikon Hospital, School of Medicine, University of Athens, Athina, Greece. - - 2013
Endothelial nitric oxide synthase (eNOS) as well as nitric oxide play an important role in the regulation of cardiovascular function. There are limited and controversial data regarding the impact of polymorphisms of eNOS gene that is implicated in the vasoconstrictive properties of the endothelium in the pathogenesis of premature myocardial ...
Zang Xiaobiao X First Affiliated Hospital of Dalian Medical University, Dalian, - - 2013
A prolonged PR interval is a sign of increased risk of cardiac arrhythmia. Recent genome-wide association studies found that the single-nucleotide polymorphism (SNP) rs3825214 in T-box 5 (TBX5) was positively associated with PR interval, QRS duration, QT interval, and common arrhythmia disorders such as atrial fibrillation (AF) and advanced atrioventricular ...
Demir Mehmet M Cardiology Department, Bursa Yüksek htisas Education and Research Hospital, Bursa, - - 2013
The bicuspid aortic valve (BAV) represents the most common cardiac congenital malformation in adults. It is frequently associated with dilation, aneurysm and dissection of the ascending aorta. To evaluate left ventricular systolic and diastolic function in subjects with BAVs. Thirty-five subjects with BAV (mean [± SD] age 25.9±5.7 years [range ...
Ozturk Serkan S Faculty of Medicine, Department of Cardiology, Abant Izzet Baysal University, - - 2013
To evaluate left ventricular (LV) systolic asynchrony and its relationship with the Tei index using tissue Doppler imaging (TDI); and to evaluate the relationship of thrombolysis in myocardial infarction frame count (TFC) and Tei index with LV asynchrony in patients with coronary artery ectasia (CAE). A total of 50 CAE ...
Tarr G P GP Department of Surgical Sciences, University of Otago, Dunedin, New - - 2013
Increased chronic postprocedural levels of active matrix metalloproteinase-9 (MMP-9) have been associated retrospectively with a history of in-stent restenosis (ISR). This study aimed to determine whether index or post-percutaneous coronary intervention (PCI) plasma levels of active MMP-9 are a predictor of subsequent clinical ISR, in a standard population of patients ...
Methner Carmen C Department of Medicine, University of Cambridge, Cambridge, United - - 2013
Stimulation of the nitric oxide (NO) - soluble guanylate (sGC) - protein kinase G (PKG) pathway confers protection against acute ischaemia/reperfusion injury, but more chronic effects in reducing post-myocardial infarction (MI) heart failure are less defined. The aim of this study was to not only determine whether the sGC stimulator ...
Francia Pietro P Cardiology, Department of Clinical and Molecular Medicine, St. Andrea Hospital, Sapienza University, Rome, - - 2013
Atrial natriuretic peptide (ANP) has antihypertrophic and antifibrotic properties that are relevant to AF substrates. The -G664C and rs5065 ANP single nucleotide polymorphisms (SNP) have been described in association with clinical phenotypes, including hypertension and left ventricular hypertrophy. A recent study assessed the association of early AF and rs5065 SNPs ...
Lin Ying-Zhong YZ Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, - - 2013
Background. CD4+ T helper (Th) cells play critical roles in the development and progression of atherosclerosis and the onset of acute coronary syndromes (ACS, including acute myocardial infarction (AMI) and unstable angina pectoris (UAP)). In addition to Th1, Th2, and Th17 cells, Th22 and Th9 subsets have been identified in ...
Navarese Eliano P EP Department of Cardiology and Internal Medicine, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, - - 2013
To investigate the safety and efficacy of durable polymer drug eluting stents (DES) and biodegradable polymer biolimus eluting stents (biolimus-ES). Network meta-analysis of randomised controlled trials. Medline, Google Scholar, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL) database search for randomised controlled trials comparing at least two of durable ...
Zheng H H Geriatrics Department, Tongji Hospital Affiliated to Tongji University, Shanghai, - - 2013
This study was aimed to determine whether the leptin receptor Gln223Arg polymorphism has an effect on plasma leptin levels and left ventricular hypertrophy in hypertension. The genotypes and allelic frequencies of the leptin receptor Gln223Arg were examined using the polymerase chain reaction and restriction fragment length polymorphism in 190 hypertensive ...
Willeit Peter P Department of Public Health and Primary Care, University of Cambridge, Cambridge, - - 2013
Activation of blood coagulation and fibrinolysis may be associated with increased risk of coronary heart disease. We aimed to assess associations of circulating tissue plasminogen activator (t-PA) antigen, D-dimer and von Willebrand factor (VWF) with coronary heart disease risk. Prospective case-control study, systematic review and meta-analyses. Measurements were made in ...
Hale Sharon L SL The Heart Institute of Good Samaritan Hospital, Los Angeles, CA, - - 2013
Nitrogen may contribute to reperfusion injury. Some studies have shown that helium as a replacement for nitrogen in breathing gas (heliox) reduces cell necrosis after ischemia/reperfusion when used in a preconditioning fashion (intermittent heliox exposure). Our aim was to test whether heliox, breathed continuously throughout the ischemic and reperfusion periods, ...
Mao Chen C Division of Epidemiology, JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Prince of Wales Hospital, 4/F School of Public Health Building, Shatin, New Territories, Hong Kong ; Shenzhen Municipal Key Laboratory for Health Risk Analysis, Shenzhen Research Institute, The Chinese University of Hong Kong, 10 Yuexing Erdao, Nanshan District, Shenzhen, Guangdong 518000, China ; The Hong Kong Branch of the Chinese Cochrane Centre, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong - - 2013
Chinese herbal medicine (CHM) has been widely used as an adjunct to western medicine in treating angina in China. We carried out this systematic review to evaluate the effectiveness of CHM on top of western medicine for angina. This meta-analysis included 46 randomized control trials with 4212 patients. For trials ...
Khosoosi Niaki Mohammad Reza MR Department of Cardiovascular Diseases, Ayatollah Rouhani Hospital, Babol University of Medical Sciences, Babol, - - 2013
Background : More than half of myocardial infracted (MI) patients have no conventional risk factors. Regarding the belief that opium addiction has a protective effect on heart diseases, addiction prevalence has unfortunately increased in recent years. This study was conducted to investigate the effect of opium addiction on patients with ...
Khosravi Samani Mahmoud M Department of Periodontics, Dental School, Babol University of Medical Sciences, Babol, - - 2013
Periodontitis is common in adults and cardiovascular diseases (CVD) are the most common cause of adult death in the world. This study aimed to investigate the relationship between CVD and periodontitis. Sixty patients with myocardial infarction (MI) as case and 63 subjects with periodontitis without MI as control were studied. ...
Cora Tulin - - 2012
Myocardial infarction (MI), which is the most important manifestation of coronary artery disease, is the leading cause of morbidity and mortality in the world. Glutathione S transferases (GSTs) are enzymes responsible for the metabolism of numerous xenobiotics and are known to be polymorphic in humans. We investigated the association between ...
Sakowicz Agata - - 2012
This study investigates the potential role of 17 chosen polymorphisms in 15 candidate genes and the risk of myocardial infarction in patients under 45 years of age. The study consists of 271 patients with myocardial infarction and 141 controls. The analysis of genetic polymorphisms was performed using the PCR-RFLP method. Of ...
Napoleão Patrícia - - 2012
Background: Auto-immune responses are associated with oxidized LDL (ox-LDL) release, a key factor in plaque destabilization. Data on the relationship between ox-LDL and T lymphocytes in human populations remains scarce. T cells also react with other molecules from the lesion and/or damage the myocardium. Objective: The objective of the present ...
Nakatani Yosuke Y Second Department of Internal Medicine, University of Toyama, Toyama, - - 2013
This study sought to assess the effects of tranilast on atrial remodeling in a canine atrial fibrillation (AF) model. Tranilast inhibits transforming growth factor (TGF)-β1 and prevents fibrosis in many pathophysiological settings. However, the effects of tranilast on atrial remodeling remain unclear. Beagles were subjected to atrial tachypacing (400 beats/min) ...
Kırış Abdulkadir - - 2012
Acromegaly is associated with a variety of cardiovascular disturbances such as left ventricular hypertrophy, diastolic cardiac dysfunction, and hypertension. Left ventricular (LV) dyssynchrony means the impairment of synchronicity and is defined as the loss of the simultaneous peak contraction of corresponding cardiac segments. The objective of this study was to ...
Suman-Horduna Irina - - 2013
This study sought to assess the impact of rhythm- versus rate-control treatment strategies and of underlying rhythm on quality of life and functional capacity in patients with atrial fibrillation (AF) and congestive heart failure (CHF). Although intention-to-treat and efficacy analyses have demonstrated similar cardiovascular outcomes in patients with AF and ...
Lader Ellis - - 2012
QUESTION In patients with left ventricular (LV) dysfunction, what is the relative efficacy of eplerenone and other aldosterone antagonists (AAs)? REVIEW SCOPE Included studies compared eplerenone or other AAs with control (placebo, angiotensin-converting enzyme inhibitor, angiotensin-receptor blocker, or β-blocker) in patients &gt; 18 years of age with symptomatic or asymptomatic LV ...
Harrington Robert A - - 2012
QUESTION In patients with acute myocardial infarction (AMI) with cardiogenic shock and planned early revascularization, does intraaortic balloon counterpulsation reduce mortality? METHODS DESIGN Randomized controlled trial (RCT) (Intraaortic Balloon Pump in Cardiogenic Shock II [IABP-SHOCK II] trial). ClinicalTrials.gov NCT00491036. ALLOCATION Concealed.* BLINDING Unblinded.* FOLLOW-UP PERIOD 30 days. SETTING 37 centers ...
Alomari Abdul-Hakeem H - - 2013
From the moment of creation to the moment of death, the heart works tirelessly to circulate blood, being a critical organ to sustain life. As a non-stopping pumping machine, it operates continuously to pump blood through our bodies to supply all cells with oxygen and necessary nutrients. When the heart ...
Haskell Sarah E - - 2013
Sertraline, a selective serotonin reuptake inhibitor (SSRI), is the most commonly prescribed therapy for maternal depression. Epidemiologic studies have linked SSRI exposure with decreased fetal growth, altered autonomic regulation, and cardiac malformations. We hypothesized that SSRI exposure decreases left-ventricular (LV) volumes and increases adult sympathetic nervous system activation, resulting in ...
Sumita Yoshikawa Wakako - - 2012
Background: Left ventricular (LV) hypertrophy is often present in patients with diastolic heart failure. However, stiffness of hypertrophied cardiomyocytes in the transverse direction has not been fully elucidated. The aim of this study was to assess passive cardiomyocyte stiffness of hypertrophied hearts in the transverse direction and the influence of actin-myosin ...
Wu Shu-I - - 2012
ObjectiveTo investigate inpatient mortality and the use of invasive diagnostic and revascularization procedures after acute myocardial infarction (AMI) in people with schizophrenia and bipolar disorder.MethodsA case-control study was nested within the first AMI episodes between 1996 and 2007 using nationwide data. Participants with schizophrenia or bipolar disorder were compared with ...
Ren Li - - 2012
Myocardial infarction is a major cause of morbidity and mortality worldwide. However, the methodological development of a spatiotemporally controllable investigation of the damage events in myocardial infarction remains challengeable. In the present study, we describe a micropillar array-aided tissue interface mimicking microfluidic device for the dynamic study of hypoxia-induced myocardial ...
Yan Ping - - 2012
Impaired left ventricular (LV) function has been shown by strain rate (SR) imaging in patients with coronary artery disease (CAD). Our aim was to investigate global and regional, systolic and diastolic left atrial (LA) and right atrial (RA) longitudinal deformation in CAD using velocity vector imaging. Echocardiographic and velocity vector ...
Mathison Megumi - - 2012
In situ cellular reprogramming offers the possibility of regenerating functional cardiomyocytes directly from scar fibroblasts, obviating the challenges of cell implantation. We hypothesized that pretreating scar with gene transfer of the angiogenic vascular endothelial growth factor (VEGF) would enhance the efficacy of this strategy. Gata4, Mef2c, and Tbx5 (GMT) administration ...
Li Jian-Ping - - 2012
As a member of Glycoprotein IIb/IIIa (GP IIb/IIIa) inhibitors, Tirofiban had been shown to improve myocardial reperfusion and clinical outcomes in patients undergoing percutaneous coronary intervention (PCI), but the optimal timing of administration of Tirofiban remains unclear. In order to compare the effects of upstream versus downstream administration of Tirofiban ...
Meena C L - - 2012
Adverse cardiovascular effect of hypothyroidism has been identified in many studies. Early identification of patients with sub-clinical hypothyroidism may lead to early treatment and thereby favourable effect on cardiovascular morbidity and mortality. To find out the association of sub clinical hypothyroidism and left ventricular dysfunction and also to find out ...
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