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Varma Niharika N Cardiovascular Imaging Department, Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United - - 2014
We investigated the feasibility of visual and quantitative assessment of coronary vessel wall contrast enhancement (CE) for detection of symptomatic atherosclerotic coronary artery disease (CAD) and subclinical coronary vasculitis in autoimmune inflammatory disease (systemic lupus erythematosus [SLE]), as well as the association with aortic stiffness, an established marker of risk. ...
Kaya Mehmet Gungor MG 1 Department of Cardiology, 2 Department of Respiratory Disease, Erciyes University School of Medicine, Kayseri, - - 2014
The aim of this study was to evaluate ventricular functions in patients with sarcoidosis without an obvious heart disease by using tissue Doppler-derived left and right ventricular myocardial performance index (MPI). The study population included 45 patient with sarcoidosis (29 men, 16 women; mean age, 44±10 years, mean disease duration, ...
Chin Calvin W L CW Department of Cardiovascular Medicine, National Heart Center Singapore, 17 Third Hospital Avenue, Mistri Wing, Singapore, 168752, Singapore, - - 2014
Endothelial dysfunction is associated with traditional and systemic lupus erythematosus (SLE)-specific risk factors, and early data suggest reversibility of endothelial dysfunction with therapy. The clinical relevance of endothelial function assessment has been limited by the lack of studies, demonstrating its prognostic significance and impact on early myocardial function. Therefore, we ...
Ramanathan K K NATIONAL UNIVERSITY HEART CENTRE SINGAPORE.. - - 2014
Non tropical, non hypereosinophilic endo myocardial fibrosis has been reported in literature and is a rare entity.  Cardiac Sarcoidosis manifesting as non-tropical, non hypereosinophilic endomyocardial fibrosis is unknown, though it classically affects the left ventricle and is not associated with specific risk factors. We describe an atypical presentation of sarcoidosis ...
Jiang Meng M Department of Cardiology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, - - 2014
We present a series of echocardiography images to demonstrate the myocardial response to a high dose of prednisone. A young woman with systemic lupus erythematosus (SLE) associated with interventricular septal hypertrophy exhibited a high pressure gradient between the ascending aorta and left ventricular outflow tract as well as significant systolic ...
Mavrogeni Sophie S Onassis Cardiac Surgery Center, Athens, Greece. Electronic address: - - 2013
Recent LBBB in connective tissue diseases (CTDs) is challenging, due to high incidence of underlying pathology that may remain undetected, due to limitations of imaging tests. We hypothesized that cardiovascular magnetic resonance (CMR) may be of diagnostic value in CTDs with recent LBBB and normal echocardiogram. 26 CTDs, aged 32±7yrs ...
Rabelo Cristina Ferreira - - 2013
Objectives. Myocarditis is a rare but serious manifestation of patients with systemic lupus erythematosus (SLE). Left ventricular noncompaction (LVNC) is a disorder of myocardial morphogenesis frequently associated to neuromuscular diseases. Hypertrabeculation, a cardinal echocardiographic feature of LVNC, might represent a morphological expression of a number of morbidities, nevertheless. The relationship ...
Mavrogeni Sophie - - 2013
Background-Aim. Accurate diagnosis of cardiovascular involvement in connective tissue diseases (CTD) remains challenging. We hypothesized that cardiovascular magnetic resonance (CMR) demonstrates cardiac lesions in symptomatic CTDs with normal echochardiography. Patients-Methods. CMR from 246 CTDs with typical (TCS) (n=146, group A) or atypical (ATCS) (n=100, group B) cardiac symptoms were retrospectively ...
Jasmin R - - 2013
We report a 13-year-old girl diagnosed with systemic lupus erythematosus (SLE) who presented with left-sided chest pain, with ECG changes and elevation troponins that were suggestive of an acute inferior wall myocardial infarction (MI). Her multi-slice computed tomography coronary angiogram and standard angiogram were normal. The cardiac magnetic resonance imaging ...
Shim In Kyoung - - 2013
Takotsubo cardiomyopathy, which is also known as "transient apical ballooning", is a cardiac syndrome associated with emotional and physical stress that occurs in postmenopausal women. It may mimic acute coronary syndrome but coronary angiography reveals normal epicardial coronary arteries. The prognosis is favorable with the normalization of wall motion abnormalities ...
Prochaska Micah T MT Internal Medicine Residency Program, University of Chicago, Chicago, Illinois, - - 2013
We describe a 59-year-old woman with cardiac conduction abnormalities caused by lupus-induced myocardial damage. She had a history of arthralgias and antinuclear antibodies but no clinical history of systemic lupus erythematosus. She presented with syncope and Mobitz type II second-degree atrioventricular block. Anti-double-stranded DNA antibodies developed coincident with the identification ...
Merinopoulos I - - 2013
A 61-year-old woman was admitted with general malaise, chest pain and breathlessness. During her inpatient stay she sustained a ventricular fibrillation (VF) arrest which was successfully terminated with direct current cardioversion. Cardiac investigations revealed poor left ventricular systolic function but unequivocally normal coronary arteries. During the course of her admission ...
Skali Hicham - - 2013
Cardiac involvement portends a poor prognosis in patients with sarcoidosis. However, due to the nonspecific clinical manifestations of the disease, patchy myocardial involvement, and the limited diagnostic yield of diagnostic tests, early diagnosis of cardiac sarcoidosis has been exceedingly difficult. As a result, there is no standardized approach for the ...
Skali Hicham H Department of Medicine, Cardiovascular Division, Boston, MA 02115, - - 2013
Cardiac involvement portends a poor prognosis inpatients with sarcoidosis. However, due to the non specific clinical manifestations of the disease, patchy myocardial involvement, and the limited diagnostic yield of diagnostic tests, early diagnosis of cardiac sarcoidosis has been exceedingly difficult. As a result, there is no standardized approach for the ...
Puntmann Valentina O - - 2013
BACKGROUND: -Increased systemic inflammation has been linked to myocardial dysfunction and heart failure in patients with systemic lupus erythematosus (SLE). Accurate detection of early myocardial changes may be able to guide preventive intervention. We investigated whether multiparametric imaging by cardiovascular magnetic resonance (CMR) can detect differences between controls and asymptomatic ...
Sharda Navreet - - 2013
Cardiac involvement is a rare initial presentation of systemic lupus erythematosus. An 11-year-old girl was described to have massive haemorrhagic pericardial effusion and cardiac tamponade, which was later diagnosed as systemic lupus erythematosus. Therefore, in children presenting with cardiac tamponade, systemic lupus erythematosus should be considered as one of the ...
Haq Ihteshamul - - 2013
We describe the case of a 50-year-old lady admitted with a 3-week history of dyspnoea and left-sided pleuritic pain associated with pleural effusion. This common clinical picture nevertheless gave rise to a significant diagnostic challenge. The medical history included a diagnosis of thyrotoxicosis made 6 months previously that was being ...
Ekka Meera M Department of Medicine, All India Institute of Medical Sciences, New Delhi, India. - - 2013
Symptomatic cardiac involvement is seen in less than 5% of all cases of sarcoidosis. Although clinically apparent cardiac sarcoidosis is an uncommon entity, ventricular tachyarrhythmias as the first presenting symptom are very rare. We discuss the case of a 41-year-old Asian woman who presented to our hospital with intermittent palpitation ...
Mavrogeni S - - 2012
Objective: The objective of this paper is to evaluate the diagnostic role of cardiac magnetic resonance imaging (CMR) in detecting myocardial inflammation in systemic lupus erythematosus (SLE) and its differentiation from viral myocarditis.Patients and methods: Fifty patients with suspected infective myocarditis (IM), with chest pain, dyspnoea or altered ECG, increase ...
Peñataro Joaquín S - - 2012
Pericarditis is the most frequent cardiac manifestation of systemic lupus erythematosus (SLE). However, a large pericardial effusion as the initial manifestation of the disease is infrequent, especially when it is associated with myocardial damage. We describe an unusual case of a young female with pleuropericarditis and severe myocardial dysfunction as ...
Yılmaz Sema - - 2012
Mortality from cardiovascular disease has been found to be increased in patients with systemic lupus erythematosus (SLE). Coronary flow reserve (CFR) measurement is used both to assess epicardial coronary arteries and to examine the integrity of coronary microvascular circulation. Oxidative stress, enhancing modification of plasma lipids, is also associated with ...
Mukerji Rita - - 2012
To assess the effect of weight loss on ventricular repolarization in morbidly obese patients, 39 normotensive subjects whose baseline body mass indexes were ≥40 kg/m(2) before weight loss from bariatric surgery were studied. All patients were free of underlying organic heart disease, heart failure, and conditions that might affect ventricular ...
Wanahita Nikolas - - 2012
The objective of this study was to assess whether statin therapy is associated with a reduction in ventricular tachyarrhythmias. Statins have been shown to be beneficial beyond their cholesterol-lowering effects. These pleiotropic effects have been implicated in the protection against atrial fibrillation and the reduction in appropriate implantable cardioverter-defibrillator therapy ...
Patel Ishita - - 2012
Sarcoidosis is a multisystem granulomatous disease of unknown aetiology. Granulomatous inflammation involving the spleen is common and associated with splenomegaly. However, massive splenomegaly is a rare occurrence. Infrequently massive splenomegaly can result in splenic infarction. Massive splenic infarction in sarcoidosis has, to our knowledge, not been previously reported. We present ...
Lee Hyung - - 2011
Acute audiovestibular loss is a common neurotological condition that is characterized by sudden onset of severe prolonged (lasting days) vertigo and hearing loss and is diagnosed by the presence of canal paresis to caloric stimulation and sensorineural hearing loss on pure tone audiogram. Before 2000, papers on anterior inferior cerebellar ...
Joost Alexander - - 2011
The introduction of stents for treatment of coronary lesions markedly improved the outcome of coronary interventions. We report on a female patient who was admitted to our hospital with acute coronary syndrome and stent loss into the left ventricle during coronary intervention performed in another hospital. Stent loss is a ...
Pegg Tammy J TJ Department of Cardiovascular Medicine, Flinders University, Flinders Drive, Flinders Medical Centre, Bedford Park SA 5042, - - 2011
To examine, using cardiac magnetic resonance (CMR), the utility of cardiac biomarkers for the determination of myocyte necrosis and function after coronary artery bypass grafting (CABG), and to test the recently updated guidelines for the diagnosis of postoperative myocardial infarction (type V MI). Forty patients included in a single-centre randomised ...
Ogano Michio - - 2011
The Brugada-type electrocardiogram (ECG) is characterized by ST-segment elevation in the right precordial ECG leads and has been reported to have the potential of sudden death. Right ventricular outflow tract supplied from the conus branch of the coronary artery (CB) is considered as the anatomopathologic substrate of Brugada syndrome. We ...
Arboix Adrià - - 2011
Cardioembolic infarction is the most severe ischemic stroke subtype, but some clinical characteristics of the disease are still poorly defined. An update of relevant aspects related to clinical manifestations, biological characteristics, prognostic implications and treatment is presented in this article. Topics discussed include epidemiology and risk factors, clinical features and ...
Dumesnil Jean G - - 2011
Prosthesis-patient mismatch (PPM) is present when the effective orifice area of the inserted prosthetic valve is too small in relation to body size. Its main hemodynamic consequence is to generate higher than expected gradients through normally functioning prosthetic valves. The purpose of this review is to present an update on ...
Chotenimitkhun Runyawan - - 2011
Noninvasive imaging modalities are often used to manage patients with cardiovascular disease. Cardiovascular magnetic resonance (CMR) is increasingly used for diagnosing and evaluating myocardial ischemia and viability; moreover, stress CMR study results can be used to determine cardiac prognosis. In this article, we review recently published material regarding the performance ...
Barrabés José A - - 2011
This article contains a review of the main developments reported in 2010 concerning the pathophysiology, prevention, prognosis and treatment of ST-segment elevation and non-ST-segment elevation acute coronary syndromes, and of recommendations made by the most recent clinical practice guidelines.
Lombard Frederick W - - 2010
PURPOSE OF REVIEW: To update the reader about clinical management strategies for separation from cardiopulmonary bypass. A number of new drugs are being introduced in clinical practice, with significant utility in operative patient management. Further, there is increased routine use of complex devices to achieve separation from or avoidance of ...
Nanda Sudip - - 2010
Premature ventricular complexes (PVCs) are a frequent occurrence in the presence of ischemic heart disease. A very high PVC load can be symptomatic or occasionally result in a cardiomyopathy (CMP). Treatment options include pharmacologic agents and radiofrequency ablation (RFA). RFA has been successful in treating PVCs in symptomatic patients or ...
Yamada Takumi - - 2010
A 62-year-old man with idiopathic ventricular tachycardia (VT) exhibiting left bundle branch block and left inferior axis QRS morphology with a Qr in lead III underwent electrophysiological testing. Successful ablation was achieved in the left ventricle (LV) at a site with an excellent pace map, adjacent to the His bundle ...
Winkel Tamara A - - 2011
Vascular surgery patients are at increased risk for late sudden cardiac death. Identification of patients at risk during surgery offers the opportunity for focused therapy. We monitored 483 vascular surgery patients who had no documented history of arrhythmias to identify perioperative new-onset ventricular tachyarrhythmia (VT) and myocardial ischemia using a ...
Yokokawa Miki - - 2011
Ventricular tachycardia (VT) in patients with idiopathic dilated cardiomyopathy often originates from the basal left ventricular myocardium and also can originate from the conduction system. The basal left ventricular myocardium reaches to the base of the aortic sinus cusps. The purpose of this study was to assess the prevalence of ...
Inada Keiichi - - 2010
Entrainment From Left Ventricular Pacing Lead. Recognizing ventricular tachycardias (VTs) that require epicardial ablation is desirable, but challenging when prior surgery prevents percutaneous epicardial mapping. This patient had cardiomyopathy, prior cardiac surgery, and VT that failed endocardial ablation. Observing that the Bi-V implantable cardioverter defibrillator (ICD), left ventricular (LV) lead ...
Murata Hiroshige - - 2010
Ventricular Tachycardia After Alcohol Septal Ablation. A 76-year-old female developed 2 different ventricular tachycardias (VTs) 5 years after alcohol septal ablation (ASA) for symptomatic hypertrophic obstructive cardiomyopathy. VT#1 was a small macroreentry at the anterior border of the low-voltage zone, suggesting the ASA-scar and eliminated by endocardial ablation at a ...
Cesario David A - - 2011
Ventricular Tachycardia in the Era of Ventricular Assist Devices.  Sustained ventricular tachycardia (VT) in patients with advanced cardiomyopathy is a potentially life-threatening arrhythmia. Newer treatment strategies have evolved that combine the use of catheter ablation to target the substrate for VT and ventricular assist devices (VADs) to hemodynamically support the ...
Bernhardt Peter - - 2011
Patients with ischemic cardiomyopathy have an increased risk for ventricular arrhythmia, since myocardial infarction can be the substrate for re-entrant arrhythmias. Contrast-enhanced cardiac magnetic resonance imaging (CMR) has proven to reliably quantify myocardial infarction. Aim of our study was to evaluate correlations between functional and contrast-enhanced CMR findings and spontaneous ...
Sarabanda Alvaro Valentim Lima - - 2011
The natural history of the arrhythmogenic form of Chagas' heart disease is not fully understood. We assessed the outcome of 56 patients with Chagas' cardiomyopathy ([31 men]; mean age of 55 years; mean left ventricular ejection fraction [LVEF] 42%) presenting with either sustained ventricular tachycardia (VT) or nonsustained VT (NSVT), ...
Dimas Vassilis - - 2011
Multiple pharmacological therapies currently in prevalent clinical use for cardiac diseases have antifibrotic properties. Spironolactone, a potent antifibrotic agent, is currently used for advanced heart failure. Therapies such as HMG-CoA reductase inhibitors (statins) and angiotensin-converting enzyme inhibitors (ACEi) also have antifibrotic properties. However, the effect of these medications on the ...
Ip James E - - 2011
Volume Overload and Ventricular Arrhythmias. Background: Acute exacerbations of heart failure (HF) are believed to trigger malignant ventricular arrhythmias, but the temporal association between fluid accumulation and ventricular arrhythmias has not been evaluated in an objective manner. We hypothesized that increased intrathoracic fluid accumulation in patients with HF, as measured by ...
Crawford Thomas - - 2010
Structural factors contributing to the development of postinfarction ventricular tachycardia (VT) are unclear. The purpose of this study was to analyze infarct architecture and electrogram characteristics in patients with and without inducible VT and to identify correlates of postinfarction VT. Twenty-four postinfarction patients (median age, 64 [53, 70] years) were ...
Kamath Ganesh S - - 2011
Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is an inherited disease that causes structural and functional abnormalities of the right ventricle (RV). The presence of late potentials as assessed by the signal-averaged electrocardiogram (SAECG) is a minor task force criterion. The purpose of this study was to examine the diagnostic and clinical ...
Krzeminski T F - - 2011
The different influences of one of the PRL isoforms (PRL I) on the cardiovascular system have been described in the past. Our goal was to establish an appropriate iv dose of 2 PRL isoforms (PRL I and PRL II) in intact rats. After establishing this dose, PRL I (0.01 mg/kg) ...
Bertini Matteo - - 2010
Quantification of segmental left ventricular (LV) strain by speckle-tracking echocardiography can identify transmural infarcts in patients with chronic ischemic cardiomyopathy. The aim of the study was to explore the relationship between the LV longitudinal peak systolic strain (LPSS) of the infarct, periinfarct, and remote zones and monomorphic ventricular tachycardia (VT) ...
Dan G A - - 2010
Initiation of ventricular tachycardia (VT) or ventricular fibrillation (VF) requires heterogeneity of the substrate. This heterogeneity has a stable/fixed component (structural or functional) and a dynamic component. The latter explains the random and sudden destabilization of the substrate and the initiation of VT or VF by a ventricular extra stimulus ...
Lim H S - - 2010
Sudden cardiac death due to ventricular arrhythmias remains the most common cause of death in developed nations. Implantable cardioverter defibrillators have been shown to improve mortality in high-risk groups for ventricular tachyarrhythmias, but they are not curative, with the risk of arrhythmia recurrence remaining unaltered. It is also important to ...
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