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Results 251 - 300 of 1620
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Viale Pamela Hallquist - - 2008
Cardiotoxicity is a well-described and potentially lethal side effect of certain chemotherapeutic agents. Cardiotoxicity is a broad term used to depict conditions ranging from benign forms of arrhythmias to potentially fatal conditions, such as myocardial ischemia or infarction and heart failure. Anthracyclines (daunorubicin, doxorubicin, and epirubicin), mitomycin, and monoclonal antibodies ...
Lo Ronald - - 2008
Ventricular arrhythmia represents a significant cause of mortality and morbidity. Its pathophysiologic mechanisms and electroanatomic substrates are slowly being elucidated. Clinical management in patients with heart failure has progressed from antiarrhythmic drugs to device therapy. Catheter ablation is an effective adjunct in the management of ventricular arrhythmia but remains a ...
Jin Hongwei - - 2008
Heart failure (HF) claims over 200,000 lives annually in the United States alone. Approximately 50% of these deaths are sudden and unexpected, and presumably the consequence of lethal ventricular tachyarrhythmias. Electrical remodeling that occurs at the cellular and tissue network levels predisposes patients with HF to malignant arrhythmias. Our limited ...
Fox David J - - 2008
Andersen-Tawil syndrome (ATS) is a rare inherited autosomal disorder characterized by the clinical triad of ventricular arrhythmias, hypokalaemic periodic paralyses, and skeletal developmental abnormalities, resulting in dysmorphic features. Although ATS patients have a high incidence of ventricular arrhythmias, the occurrence of sudden cardiac death is rare. In this report, we ...
Bogun Frank - - 2008
OBJECTIVES: The aim of this study was to define the role of papillary muscles (PAPs) in post-infarction ventricular arrhythmias. BACKGROUND: Papillary muscles have been implicated in arrhythmogenesis; however, their role in post-infarction ventricular arrhythmias has not been well-defined. METHODS: In a series of 9 patients (age 65 +/- 9 years, ...
Myles Rachel C - - 2008
T-wave alternans is considered a potentially useful clinical marker for the risk of ventricular arrhythmia in patients with heart disease. Cellular repolarisation alternans is thought to underlie T-wave alternans, and moreover, to cause re-entrant ventricular arrhythmia. This review examines the experimental and clinical evidence linking repolarisation alternans and T-wave alternans ...
Annane Djillali - - 2008
RATIONALE: Sustained arrhythmias are common in postoperative and cardiac intensive care units (ICUs), but their incidence and prognosis in general ICUs have never been reported. OBJECTIVES: To estimate the incidence and prognosis of sustained arrhythmias in a general ICU population. METHODS: Prospective, multicenter, 1-month inception cohort study. MEASUREMENTS AND MAIN ...
Shan Lishen - - 2008
Left ventricular noncompaction (LVNC) is a genetically heterogenous disorder. Mutations in the human cardiac sodium channel alpha-subunit gene (SCN5A) are involved in the pathophysiology of cardiac arrhythmias and cardiomyopathies. This study was performed to compare the frequency of SCN5A variants in LVNC patients with or without arrhythmias, and to investigate ...
Chaiyarak Kanoknaphat - - 2008
OBJECTIVES: To determine the incidence, risk factors and outcome of early postoperative arrhythmias in pediatric patients with congenital heart disease. MATERIAL AND METHOD: A prospective study was conducted in every pediatric patient who consecutively underwent open-heart surgery at Siriraj Hospital from January 1st to December 31st, 2006. The collected data ...
Gorenek Bulent - - 2008
Several kinds of arrhythmias, such as ventricular arrhythmias, atrial fibrillation, bradycardias and conduction disturbances can occur in cardiac catheterization laboratories. The patients' characteristics, the type of procedure, the features of the target vessel and the type of lesion play important roles in the occurrence of arrhythmia. A majority of the ...
Jie Xiao X Department of Biomedical Engineering and Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD, - - 2008
Delayed ventricular arrhythmias during acute myocardial ischemia (1B arrhythmias) are associated with an increase in tissue impedance and are most likely sustained in a thin subepicardial layer. The goal of this study was to test the hypothesis that heterogeneous uncoupling between depolarized midmyocardium and surviving subepicardium results in heterogeneous refractoriness ...
Yiu K-H - - 2008
Hypertension is commonly associated with cardiac arrhythmias in patients with and without concomitant cardiovascular disease. Experimental and epidemiological studies have demonstrated potential links between hypertension and atrial and ventricular arrhythmias, although the underlying pathophysiological mechanism remains unclear. Nonetheless, the importance of hypertension as a cause of atrial and ventricular arrhythmias ...
Stein Phyllis K - - 2008
Cardiac patients often have sinus arrhythmia of nonrespiratory origin (erratic sinus rhythm [ESR]). ESR was quantified using hourly Poincaré and power spectral heart rate variability plots from normal-to-normal interbeat intervals and hourly values of the short-term fractal scaling exponent and correlations of normal-to-normal intervals in n = 60 nonsurvivors and ...
Goette Andreas - - 2008
In the recent years, a tremendous amount has been learned about the pathophysiology and molecular biology of the cardiac angiotensin II system. Interestingly, the angiotensin II appears to have several effects on cardiac electrophysiology, which have not been fully appreciated so far. Therefore, this review will highlight on the basic ...
Deal Barbara J - - 2008
Long-term survival after repair of complex congenital heart lesions is associated with the late development of arrhythmias as well as residual hemodynamic abnormalities. Understanding arrhythmias as electromechanical problems provides the basis for surgical intervention to correct the arrhythmia as well as anatomical disturbances. Operative techniques are highly effective in treating ...
Subbiah Rajesh - - 2008
Elucidating the underlying cause of unexplained syncope, palpitations or other possible arrhythmia-related symptoms is a formidable clinical challenge. Cardiac monitoring supplements the most important "test" in patients with syncope or palpitations, that of a thoughtful history and physical examination. Ideally, comprehensive physiologic monitoring during spontaneous symptoms would constitute what, at ...
Juan Oscar - - 2008
Lung cancer involvement of the heart is not unusual, but in most cases is silent. Arrhythmia and electrocardiographic findings suggesting an acute myocardial infarction could be the first manifestation of myocardial infiltration by the tumour. Echocardiography could be a valuable tool to define the diagnosis in patients with lung cancer ...
Couceiro R - - 2008
Premature Ventricular Contractions (PVC) are a cardiac arrhythmia that can be associated with an increased risk of adverse cardiac events such as ventricular arrhythmias and sudden death. Therefore, the characterization of this arrhythmia becomes crucial in the early diagnosis and prevention of possible life threatening cardiac diseases. In this paper ...
Frontera Jennifer A - - 2008
OBJECTIVE: Serious cardiac arrhythmias have been described in approximately 5% of patients after subarachnoid hemorrhage (SAH). The aim of this study was to identify the frequency, risk factors and clinical impact of cardiac arrhythmia after SAH. METHODS: We prospectively studied 580 spontaneous SAH patients and identified risk factors and complications ...
Portet François - - 2008
Automatic detection of atrial activity (P waves) in an electrocardiogram (ECG) is a crucial task to diagnose the presence of arrhythmias. The P wave is difficult to detect and most of the approaches in the literature have been evaluated on normal sinus rhythms and rarely considered arrhythmia contexts other than ...
Muñoz Rosa I - - 2008
Cardiac arrhythmias are a frequent event in chronic hemodialysis patients. The aim of this study was to evaluate the efficacy and safety of acetate-free hemofiltration with potassium-profiled dialysate (AFB-K) dialysis compared with constant potassium acetate-free biofiltration (AFB). Twelve patients (mean age 79 years) affected by cardiac arrhythmias or at a ...
Tribulová N - - 2008
Direct cell-to-cell communication in the heart is maintained via gap junction channels composed of proteins termed connexins. Connexin channels ensure molecular and electrical signals propagation and hence are crucial in myocardial synchronization and heart function. Disease-induced gap junctions remodeling and/or an impairment or even block of intercellular communication due to ...
Emilsson Kent - - 2008
Premature ventricular complexes are to some extent a normal finding in healthy individuals and the prevalence increases with age and is more common in men. Premature ventricular complexes can occur in association with a variety of stimuli, and a lesser known cause is the association between air pollution and ventricular ...
Vohra Rais - - 2008
INTRODUCTION: Hydrofluoric acid (HF) is a weak inorganic acid used for etching and as rust remover. Systemic toxicity is manifested as ventricular dysrhythmias. The mechanisms for these dysrhythmias are not well elucidated. CASE REPORT: An 82-year-old woman ingested 8 ounces of 7% HF. Shortly after emergency department (ED) arrival, she ...
Lüderitz Berndt - - 2008
The diagnosis and treatment of clinical electrophysiology has a long and fascinating history. From the earliest time, no clinical symptom impressed the patient (and the physician) more than an irregular heart beat. Although ancient Chinese pulse theory laid the foundation for the study of arrhythmias and clinical electrophysiology in the ...
Wang Linwei - - 2008
Identification of infarct substrates provides necessary guidance to the prevention and treatment of cardiac arrhythmias. Compared to diagnostic criteria of body surface potentials (BSP) or electrophysiological information on heart surfaces, the underlying volumetric cardiac electrical activity is of more direct clinical relevance in exhibiting patient-specific arrhythmic dynamics and arrhythmogenic substrates. ...
Schiek Michael - - 2008
The intermittent occurrence of cardiac arrhythmias like e.g. atrial fibrillation hampers their diagnosis and hence the treatment. Since persons suffering from atrial fibrillation are known to have a remarkable increased risk of stroke the diagnosis of atrial fibrillation is a matter of great importance. Easy and comfortable to use long ...
Asirvatham Samuel J - - 2008
Although interventional electrophysiology and the use of radiofrequency energy to cure various arrhythmias primarily developed in the adult population, similar applications in children have grown dramatically over the last decade. The anatomic basis for various arrhythmias is critically important for the pediatric ablationists to appreciate. Such understanding allows the use ...
Ramesh Iyer V - - 2008
Tachycardia induced cardiomyopathy (TIC) is defined as atrial or ventricular dysfunction as a result of prolonged elevated heart rate that is reversible upon control of the arrhythmia. There may be no underlying structural heart disease primarily responsible for the cardiac dysfunction. We present some examples of arrhythmias causing TIC and ...
Barta Judit - - 2008
Antiplatelet agents, sarpogrelate (SAR), a 5-hydroxy tryptamine 2A receptor antagonist and cilostazol (CIL), a phosphodiesterase-III inhibitor, were observed to be beneficial in attenuating cardiac remodeling and improving cardiac function in congestive heart failure due to myocardial infarction in rats; however, CIL increased ventricular tachycardia and mortality. In order to study ...
Jia Zhiheng - - 2008
Alternans, a beat-to-beat alternation in cardiac signals, may serve as a precursor to lethal cardiac arrhythmias, including ventricular tachycardia and ventricular fibrillation. Therefore, alternans is a desirable target of early arrhythmia prediction/detection. For long-term records and in the presence of noise, the definition of alternans is qualitative and ambiguous. This ...
Winckels, S.K.G.
Following cardiac diseases such as an insufficient valve or a myocardial infarction, the heart attempts to adapt to the new situation. The heart can adapt its structure or contractility, but it can also adapt its electrical properties. This phenomenon is called electrical remodelling and is associated with an increased sensitivity ...
Gandhi Sanjiv K - - 2007
Atrial reentrant tachycardias are a common source of morbidity in children with significant structural heart disease, especially following cardiac surgery. Preexisting atrial geometry combined with the hemodynamic effect of a congenital cardiac defect and electrophysiological alterations caused by surgical lesions can create large anatomic-functional barriers to conduction, allowing reentrant wavefronts ...
Zhao Jing-lin - - 2008
BACKGROUND: In animal models, pretreatment with statin can prevent reperfusion arrhythmia. In the observational study, we investigated whether pretreatment with statin may prevent reperfusion arrhythmia in patients who underwent primary coronary intervention for acute myocardial infarction (AMI). METHOD AND RESULTS: A total of 226 consecutive patients who underwent successful primary ...
Heper Gulumser - - 2008
Reperfusion arrhythmias are associated with epicardial reperfusion but may also be a sign of vascular reperfusion injury which can be seen as no-reflow phenomenon on coronary angiography and predicts in-hospital complications and recovery of left ventricular (LV) function. No-reflow phenomenon (thrombolysis in myocardial infarction [TIMI] <or=2 flow) is frequently observed ...
Antoons Gudrun - - 2007
Malignant ventricular tachyarrhythmias are common among patients with hypertrophy and heart failure, and these arrhythmias can initiate by triggered activity. Abnormal repolarization and disturbed calcium handling due to remodeling processes are common features of the hypertrophied and failing heart that conspire to facilitate triggering events. These changes have a different ...
Moshal Karni S - - 2007
Although cardiac synchronization is important in maintaining myocardial performance, the mechanism of dys-synchronization in ailing to failing myocardium is unclear. It is known that the cardiac myocyte contracts and relaxes individually; however, it synchronizes only when connected to one another by low resistance communications called gap junction protein (connexins) and ...
Fotuhi Parwis - - 2007
AIMS: Aim of this study was to investigate the effect of intracoronary administration of freshly isolated adipose-derived mononuclear cells (ADMCs) on myocardial vulnerability to arrhythmia induction after infarction. METHODS AND RESULTS: A transmural myocardial infarction in an experimental porcine model was induced by occlusion of the mid-left anterior descending artery ...
Branco Dorothy M - - 2007
BACKGROUND: Duchenne muscular dystrophy (DMD) is a progressive muscle disease caused by mutations in the dystrophin gene. Cardiomyopathy, conduction abnormalities, and ventricular arrhythmias are significant complications of this disease. The mdx ( 5cv ) mouse carries a dystrophin mutation and demonstrates a more severe phenotype than the classic mdx mouse. ...
Kjølbye Anne Louise - - 2007
Existing anti-arrhythmic therapy is hampered by lack of efficacy and unacceptable side effects. Thus, ventricular tachycardia and fibrillation remains the strongest predictor of in-hospital mortality in patients with myocardial infarction. In atrial fibrillation, rhythm control with conventional ion channel blockers provide no therapeutic benefit relative to rate control. Several lines ...
Gwak Mi Sook - - 2007
Liver allograft recipients may develop a hyperdynamic circulation and cardiac electrophysiologic abnormalities. The incidence of severe ventricular arrhythmias in liver allograft recipients during pulmonary artery (PA) catheterization was determined. One hundred five liver allograft recipients were studied prospectively; 5 of the patients with preexisting valvular heart disease, ischemic heart disease, ...
Drolet Benoît - - 2007
Research in the field of basic electrophysiology at the Quebec Heart Institute (Laval Hospital, Quebec City, Quebec) has evolved since its beginning in the 1990s. Interests were focused on cardiac arrhythmias induced by drugs, allelic variants and metabolic factors produced during ischemia. The results have contributed to the creation of ...
Olkowski A A - - 2008
Sudden death syndrome (SDS) in fast growing broiler chickens has been recognized as a patho-physiological entity for four decades, but its pathogenesis still remains unknown. More recent investigations provided evidence that link SDS to cardiac arrhythmia, but the mechanism triggering arrhythmogenesis and factors responsible for fatal outcome are poorly understood. ...
Kaiser Lana - - 2007
Cardiac events, including heart failure and arrhythmias, are the leading cause of death in patients with beta thalassemia. Although cardiac arrhythmias in humans are believed to result from iron overload, excluding confounding factors in the human population is difficult. The goal of the current study was to determine whether cardiac ...
Vollkron Michael - - 2007
BACKGROUND: Axial blood pumps have very successfully entered the arena of prolonged clinical support. However, they offer only limited inherent load-responsive mechanisms for adjusting pumping performance to venous return and changes in the physiologic requirements of the patient. Therefore, excessive ventricular unloading can be observed in various situations of temporarily ...
Wang Luke Y-J - - 2007
BACKGROUND: Patients with infantile-onset Pompe disease suffer from marked hypertrophic cardiomyopathy and an increased risk of arrhythmia. A noncompliant left ventricle predisposes these infants to diastolic heart failure with elevated left ventricular enddiastolic pressure (LVEDP); these patients also commonly develop systolic heart failure. Given this baseline cardiac physiology, coronary perfusion ...
Grantham Hugh J M - - 2007
BACKGROUND: Anything other than normal sinus rhythm can be classified as an arrhythmia. However not all arrhythmias need acute intervention. OBJECTIVE: This article reviews which arrhythmias need intervention in an acute setting, and the various options available for intervention. DISCUSSION: The impact of an arrhythmia upon perfusion determines what intervention ...
Kistler Peter M - - 2007
BACKGROUND: Cardiac arrhythmias may present with palpitations, chest pain, shortness of breath, dizziness and syncope. Diagnosis may be complicated by an inability to document the arrhythmia particularly when symptoms are infrequent and short lived. OBJECTIVE: This article aims to provide an overview of the pharmacological management of supraventricular tachycardia including ...
Oosterhoff Peter - - 2007
Hypertrophy and heart failure are associated with an enhanced propensity for cardiac arrhythmias and a high mortality rate. Altered repolarization might play a role in the occurrence of these ventricular arrhythmias. Beat-to-beat variability of repolarization duration (BVR) has been proposed as a parameter for detection of an unstable, and less ...
Portaluppi Francesco - - 2007
It is now well established that nearly all functions of the body, including those that influence the pharmacokinetics and pharmacodynamics of medications, exhibit significant 24-hour variation. The electrical properties of the heart as well as cardiac arrhythmias also vary as circadian rhythms, even though the suboptimal methods initially used for ...
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