Search Results
Results 201 - 250 of 1620
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Kirk P - - 2009
The goal of this study was to determine the predictive value of cardiac T2* magnetic resonance for heart failure and arrhythmia in thalassemia major. We analyzed cardiac and liver T2* magnetic resonance and serum ferritin in 652 thalassemia major patients from 21 UK centers with 1442 magnetic resonance scans. The ...
Hatzitolios A - - 2009
Amiodarone, the major representative of class III antiarrhythmic agents, is widely used in the treatment of ventricular and hyperventricular arrhythmias, being specifically useful in the therapy of patients suffering from life threatening ventricular arrhythmias. The combination of antianginal and antiarrthythmic actions of amiodarone is an extremely significant advantage regarding the ...
Goldsmith Yuliya B - - 2009
Cardiac patients with systemic light-chain amyloidosis have a high incidence of arrhythmias and arrhythmia-related death. We aimed to describe the arrhythmias, determine patient characteristics associated with the development of ventricular arrhythmias, and the utility of telemetric monitoring in patients with cardiac involvement due to AL amyloidosis undergoing stem cell transplantation ...
Kadmon Ehud - - 2010
We present a case of a 45-year-old man with an incidental and longstanding diagnosis of extensive mediastinal and cardiac lipomatosis. Along the years, he had experienced various arrhythmias, mainly bradyarrhythmias, mostly asymptomatic. Recently after documenting a sinus pause of 6 seconds and runs of nonsustained ventricular tachycardias, he underwent an ...
Miyazaki Aya - - 2009
BACKGROUND: Refractory arrhythmias caused by right ventricular (RV) volume overload resulting from pulmonary regurgitation are the main concern in adult patients after repair of tetralogy of Fallot (TOF). Early pulmonary valve replacement (PVR) may prevent irreversible RV dysfunction and refractory arrhythmias, so the present study evaluated the PVR outcomes in ...
Wacker M J - - 2009
We have recently reported that left atrial injections of the thromboxane A(2) (TXA(2)) mimetic, (5Z)-7-[(1R,4S,5S,6R)-6-[(1E,3S)-3-hydroxy-1-octenyl]-2 -oxabicyclo[2.2.1]hept-5-yl]-5-heptenoic acid (U46619), induced ventricular arrhythmias in the anesthetized rabbit. Data from this study led us to hypothesize that TXA(2) may be inducing direct actions on the myocardium to induce these arrhythmias. The aim of ...
Araújo Claudio Gil - - 2009
AIMS: To describe the frequency and type of arrhythmia induced by forced expiratory and inspiratory flow-volume loop manoeuvres. METHODS: 735 subjects (548 men) aged from 10 to 98 years old (mean 54 years, SD +/- 15) were submitted to a conventional medical examination and spirometry testing prior to a maximal ...
Hasan-Ali H - - 2009
We studied dialysis-associated arrhythmia in 48 uraemic patients < 35 years on chronic haemodialysis (HD) (> 3 months). Holter findings showed only minor arrhythmia; atrial in 42% of patients and ventricular in 38%. ST-segment depression > 1 mm was observed in 58% of patients; 80% had arrhythmia, and 36% experienced ...
Marcus Gregory M - - 2009
OBJECTIVES: This study sought to examine the efficacy of empiric antiarrhythmic drugs in a rigorously characterized cohort of arrhythmogenic right ventricular cardiomyopathy (ARVC) patients. BACKGROUND: Antiarrhythmic drugs are important in protecting against ventricular arrhythmias in ARVC, but no studies have provided data in a group rigorously screened for the disease. ...
Asirvatham Samuel J - - 2009
Radiofrequency ablation in the outflow tract and great arteries is increasingly performed to treat a variety of symptomatic cardiac arrhythmias. The regional anatomy of these structures is among the most complex of those encountered by cardiac electrophysiologists. An exact appreciation of the relationships between these overlapping structures and their proximity ...
Kaiser Lana - - 2009
Chronic iron overload associated with hereditary hemochromatosis or repeated red cell transfusions is known to cause cardiac failure. Cardiac arrhythmias have been incidentally noted in patients with iron overload, but they are often dismissed as being related to comorbid conditions. Studies with anesthetized iron-loaded gerbils using short recordings suggest a ...
Gandhi Chintan - - 2009
Among the heart diseases, ischemia and reperfusion (I/R) induced arrhythmias contribute to episodes of sudden death. Cardiac arrhythmias during ischemia reperfusion are believed to be related to oxidative stress. Therefore, the aim of this study was to examine whether treatment with hesperidin alleviates arrhythmias and infarct size in experimentally-induced myocardial ...
Chopra Nagesh - - 2009
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare inherited disease characterized by physical or emotional stress-induced ventricular arrhythmias in the absence of any structural heart disease or QT prolongation. Thus far, mutations in genes encoding the sarcoplasmic reticulum Ca(2+) release channel (RYR2) and the sarcoplasmic reticulum Ca(2+) binding protein cardiac ...
Borleffs C Jan Willem - - 2009
AIMS: To assess the long-term rate of mortality and the recurrence of potentially life-threatening ventricular arrhythmias in secondary prevention implantable cardioverter defibrillator (ICD) patients and to construct a model for baseline risk stratification. METHODS AND RESULTS: Since 1996, all patients with ischaemic heart disease, receiving ICD therapy for secondary prevention ...
Peres E E Department of Hematology and Oncology, Karmanos Cancer Institute, Wayne State University Medical School, Detroit, MI, USA. - - 2010
Reduced-intensity conditioning (RIC) extends hematopoietic stem cell transplants (HSCT) to elderly or debilitated patients who are not candidates for HSCT. The incidence and outcomes of cardiac complications have been reported following myeloablative HSCT. We assessed the incidence and outcomes of cardiac complications in 278 recipients of RIC from July 2000 ...
Vesin Claire - - 2009
BACKGROUND: In elderly patients traditional cardiovascular (CV) risk factors are poorly correlated with mortality and few data are available on determinants and consequences of supra-ventricular arrhythmia. In a cohort of 331 hospitalized elderly patients (mean age+/-SD=85+/-7 years), we assessed which CV characteristics were associated with all-cause mortality. AIM OF THE ...
Hashemi Seyed M - - 2009
Ankyrins are critical components of ion channel and transporter signaling complexes in the cardiovascular system. Over the past 5 years, ankyrin dysfunction has been linked with abnormal ion channel and transporter membrane organization and fatal human arrhythmias. Loss-of-function variants in the ankyrin-B gene (ANK2) cause "ankyrin-B syndrome" (previously called type ...
Breckenridge Ross A RA MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK. - - 2009
Elevated levels of the cardiac transcription factor Hand1 have been reported in several adult cardiac diseases but it is unclear whether this change is itself maladaptive with respect to heart function. To test this possibility, we have developed a novel, inducible transgenic system, and used it to overexpress Hand1 in ...
Fiorelli A I - - 2009
OBJECTIVE: Arrhythmogenic right ventricular dysplasia (ARVD) is a myocardial disease of familiar, origin where the myocardium is replaced by fibrofatty tissue predominantly in the right ventricle. Herein we have presented the clinical courses of 4 patients with ARVD who underwent orthotopic heart transplantation. PATIENTS AND METHODS: Among 358 adult patients ...
Chan Thomas Y K - - 2009
Aconitine and related alkaloids found in the Aconitum species are highly toxic cardiotoxins and neurotoxins. The wild plant (especially the roots and root tubers) is extremely toxic. Severe aconite poisoning can occur after accidental ingestion of the wild plant or consumption of an herbal decoction made from aconite roots. In ...
Li Jun - - 2009
The cardioprotective effects of estrogen remain controversial in clinical practice. Previous reports have shown that cardioprotective mechanisms converge on the mitochondria, but the role of mitochondria in estrogen's actions on cardiac arrhythmias is unclear. Here, we report that stimulation or inhibition of mitochondrial benzodiazepine receptors (mBzR) affected ventricular fibrillation (VF) ...
Waldeyer Christoph - - 2009
Although numerous studies have reported the effects of genetic alterations on murine electrophysiology, the range of normal values for ventricular activation, repolarization, and arrhythmias in mouse hearts is not known. We analyzed right ventricular (RV), left ventricular (LV), and septal activation times, monophasic action potential durations (APD), and right ventricular ...
Scheinman Melvin M - - 2009
Although a plethora of earlier studies focused on the histology and action potential characteristics of Purkinje fibers, only recently has the His-Purkinje system been found to play a major role in the genesis of cardiac arrhythmias. The anatomic complexity of the left ventricular conduction system appears to favor reentrant arrhythmias ...
Markowitz Steven M - - 2009
In classifying ventricular arrhythmias, a fundamental distinction is made between focal and macroreentrant mechanisms. Focal arrhythmias demonstrate early activation at a particular site with centrifugal spread of the impulse from this site of origin. In contrast, macroreentrant rhythms involve contiguous but spatially distributed areas of activation. Despite advances in multielectrode ...
Sato Daisuke - - 2009
The synchronization of coupled oscillators plays an important role in many biological systems, including the heart. In heart diseases, cardiac myocytes can exhibit abnormal electrical oscillations, such as early afterdepolarizations (EADs), which are associated with lethal arrhythmias. A key unanswered question is how cellular EADs partially synchronize in tissue, as ...
Talbi M L - - 2009
This paper deals with the discrimination of premature ventricular contraction (PVC) arrhythmia using the fractal behavior of the power spectrum density of the QRS complexes. The linear interpolation of the QRS complex power spectrum density in Bode diagram in two different frequency intervals gives two straight lines with two different ...
Atik Fernando A - - 2009
A 63-year-old diabetic woman was emergently submitted to coronary artery bypass grafting in the setting of acute myocardial infarction. Recurrent, drug-refractory episodes of ventricular arrhythmia occurred for 2 weeks postoperatively, despite no documentation of ongoing myocardial ischemia and optimum medical treatment. Ventricular arrhythmia was initiated by premature ventricular contractions originating ...
Farah, ME; ;
Ventricular arrhythmias (VAS), Including ventricular tachycardia (VT), ventricular fibrillation (VF) and Brady-arrhythmias, are life-threatening complications of acute myocardial infarction (MI). Objective: To study the incidence of ventricular arrhythmias, brady-arrhythmias and Sudden Cardiac Death (SCD) in Sudanese patients with acute MI. Methodology: This is a prospective cross sectional, hospital based study, ...
Boukens Bastiaan J D - - 2009
Reentry is the main mechanism of life-threatening ventricular arrhythmias, including ventricular fibrillation and tachycardia. Its occurrence depends on the simultaneous presence of an arrhythmogenic substrate (a preexisting condition) and a "trigger," and is favored by electrophysiological heterogeneities. In the adult heart, electrophysiological heterogeneities of the ventricle exist along the apicobasal, ...
Lüderitz Berndt - - 2009
The diagnosis and treatment of clinical electrophysiology has a long and fascinating history. From earliest times, no clinical symptom impressed the patient (and the physician) more than an irregular heart beat. Although ancient Chinese pulse theory laid the foundation for the study of arrhythmias and clinical electrophysiology in the 5th ...
Buemi Michele - - 2009
Cardiovascular diseases represent the main causes of death in patients affected by renal failure, and arrhythmias are frequently observed in patients undergoing hemodialysis. Dialytic treatment per se can be considered as an arrhythmogenic stimulus; moreover, uraemic patients are characterized by a "pro-arrhythmic substrate" because of the high prevalence of ischaemic ...
Gomes Pedro R - - 2009
This paper reports a comparative study of feature extraction methods regarding cardiac arrhythmia classification, using state of the art Hidden Markov Models. The types of beat being selected are normal (N), premature ventricular contraction (V) which is often precursor of ventricular arrhythmia, two of the most common class of supra-ventricular ...
Hirata Naoyuki - - 2009
BACKGROUND: The effects of anesthetics on ischemia-induced ventricular arrhythmias remain poorly studied. This study investigated the effects of propofol and sevoflurane on the survival rate and morbidity as a result of ventricular arrhythmias, and defined a possible mechanism for the arrhythmogenic properties of anesthetics during acute myocardial ischemia. METHODS: Under ...
Rosen Michael R - - 2009
Gene and cell therapies of cardiac arrhythmias are nascent fields whose raison d'etre derives from (1) the problematic state of arrhythmia treatment today (especially atrial and ventricular tachyarrhythmias for which drugs, devices and ablation remain more stopgaps then optimal interventions), and (2) the opportunity to learn and potentially treat and ...
Ksela Jus - - 2009
BACKGROUND: De-novo ventricular arrhythmias are potentially life-threatening complications after beating-heart revascularization (off-pump CABG). Whether pulmonary hypertension can influence initiation of ventricular arrhythmias through increased sympathetic activity is controversial. In order to determine the influence of pulmonary hypertension on its relative contribution to ventricular arrhythmia, we first had to define the ...
Abuin Gustavo - - 2009
The incidence of arrhythmias after acute myocardial infarction of the inferior wall varies with the affected segment and increases when there is right ventricular involvement. This paper provides a clear review of the blood supply to the conduction system and gives an anatomic explanation of that supply.We dissected 20 human ...
Araújo Cristiana Marques de - - 2009
There is controversy regarding whether obstructive sleep apnea is responsible for triggering myocardial ischemia, arrhythmias and heart rate variability in patients with coronary artery disease. The objective of this study was to identify relationships between sleep apnea, myocardial ischemia and cardiac arrhythmia in patients with coronary artery disease. Fifty-three patients ...
Deal Barbara J - - 2008
A detailed hierarchal nomenclature of arrhythmias is offered with definition of its applications to diagnosis and complications. The conceptual and organizational approach to discussion of arrhythmias employs the following sequence: location--mechanism--aetiology--duration. The classification of arrhythmias is heuristically divided into an anatomical hierarchy: atrial, junctional, ventricular, or atrioventricular. Mechanisms are most ...
God Epotamenides Maria Good - - 2008
BACKGROUND: Ventricular arrhythmic events have a strong impact on the mortality of patients with heart failure. The benefits of the optimized drug treatment of heart failure in reducing ventricular arrhythmia have not been well documented yet. OBJECTIVE: To analyze the effects of the optimized drug treatment of heart failure on ...
Côté E - - 2008
BACKGROUND: Ventricular tachyarrhythmias occur in association with cardiac and extracardiac disorders in many species of animals, but information identifying concurrent disorders in cats with such arrhythmias is scarce. METHODS: We investigated coexisting diseases by retrospectively evaluating medical records of cats with ventricular tachyarrhythmias seen during a 51-month period at 1 ...
Rodriguez E - - 2008
We applied detrended fluctuation analysis to characterize at very short time scales during episodes of cardiac arrhythmias the raw electrocardiogram (ECG) waveform, aiming to get a global insight into its dynamical behaviour in patients who experienced sudden death. We found that in 15 recordings involving different types of arrhythmias (taken ...
Nadkarni Powlimi J - - 2008
BACKGROUND: Cardiac arrhythmias associated with thyrotoxicosis tend to be supraventricular in nature with atrial fibrillation being the most common. Ventricular arrhythmias are rarely associated with thyrotoxicosis and are considered to be secondary to intrinsic cardiac disease. SUMMARY: We present three patients with thyrotoxicosis and stable coronary disease in whom the ...
Goodman Sergei - - 2008
PURPOSE OF REVIEW: To explore recent findings on the treatment and outcome of cardiac arrhythmias and how they affect ICU activities. RECENT FINDINGS: The rate vs. rhythm control debate for the treatment of chronic atrial fibrillation continues. It is still unclear whether the postcardiac surgery inflammatory response contributes to the ...
McDowell Roddy - - 2008
Enzyme replacement therapy in infants with Pompe disease prolongs survival, decreases cardiomegaly, and improves muscle function. Because ectopy has been previously described in these patients, we sought to determine the prevalence and types of arrhythmias. Thirty-eight children with infantile Pompe disease received enzyme replacement therapy in two open-label, multicenter, international, ...
Eaton P P Cardiovascular Division, The Rayne Institute, St Thomas Hospital, London, - - 2008
The factors that determine susceptibility to lethal ventricular arrhythmias during myocardial ischaemia and reperfusion in vivo are complex, but the balance between proarrhythmic and antiarrhythmic endogenous substances is likely to be important. However, in this context, it is not well established what effect endogenously produced peroxynitrite has on arrhythmias that ...
Moya Angel - - 2008
The reproducibility of electrocardiographic (ECG) recordings in syncopal recurrences and the diagnostic role of nonsyncopal arrhythmias are not well known. The objective of this study was to analyse the reproducibility of the ECG findings recorded with implantable loop recorders in 41 patients with suspected neurally-mediated syncope who were included in ...
VanWormer Arin M - - 2008
Cardiac arrhythmias increase mortality and diminish quality of life. Several online databases were searched to produce relevant articles examining the effectiveness of acupuncture on cardiac arrhythmias. Acupuncture has been used for thousands of years in Eastern medicine to treat multiple medical conditions and has been documented to improve many aspects ...
V. Thulasi Bai, S.K. ...
Arrhythmias are disorders of the regular rhythmic beating of the heart. They may indicate a serious problem and lead to heart disease, stroke or sudden cardiac death. The aim of the research reported in this paper is to design and implement a portable monitoring and alerting telemedicine system for cardiac ...
Good Eric - - 2008
BACKGROUND: The papillary muscles (PAP) have been implicated in arrhythmogenesis, largely based on theoretical considerations and experimental studies. Few clinical studies have described papillary muscle arrhythmias. OBJECTIVE: This study sought to describe ventricular arrhythmias arising from the left ventricular PAPs in a consecutive series of patients without prior myocardial infarction ...
Mavroudis Constantine - - 2008
BACKGROUND: Arrhythmia surgery has favorably impacted the clinical course of debilitating atrial and ventricular arrhythmias in patients with and without congenital heart disease. This study reviews arrhythmia mechanisms and documents long-term outcome of patients undergoing arrhythmia operations alone or associated with congenital heart repairs. The analysis excludes Fontan conversion patients. ...
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