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Gorki H - - 2011
BACKGROUND: Adequate perfusion of the right ventricle with retrograde cardioplegia has always been questioned. However, clinical studies suggested sufficient protection and, up to now, intraoperative assessment of cardioplegia distribution has been difficult. METHODS: As a pilot study in 14 patients, we used indocyanine green laser fluorescence angiography (ICGLA) to assess ...
Challa Prasanna K - - 2011
Catheter ablation has become an important and widely used treatment modality for patients with symptomatic atrial fibrillation. The superior efficacy of catheter ablation over antiarrhythmic therapy has been well established. The understanding of the pathophysiology of atrial fibrillation has led to the development of catheter-based ablation techniques. The development of ...
Suinesiaputra Avan - - 2011
To correlate an automated regional wall motion abnormality (RWMA) detection method based on combined rest and dobutamine-stress cardiac MRI with the assessment of myocardial infarction from contrast-enhanced MRI (CE-MRI), and to demonstrate that adding stress data improves the detection of scar segments compared with rest data alone. An automated RWMA ...
Uchida Yasumi - - 2011
Percutaneous cardioscopy, using high-resolution fiberoptic imaging, enables direct visualization of the cardiac interior, thereby enabling macroscopic pathological diagnosis. Percutaneous cardioscopy has demonstrated that the endocardial surface exhibits various colors characteristic of different heart diseases. This imaging modality can now be used for evaluation of the severity of myocardial ischemia, and ...
Aydın Funda F Akdeniz University Medical School, Department of Nuclear Medicine, Antalya, - - 2011
Technetium-99m methoxy-isobutylisonitrile (Tc-99m MIBI) is a routinely used radiopharmaceutical for myocardial perfusion scintigraphy (MPS). It is also a tumor seeking agent. Here, we present a case of 51 year old male who underwent Tc-99m MIBI myocardial perfusion study due to permanent chest pain after coronary angiography. Abnormal MIBI uptake in ...
Chen Ji J Department of Radiology and Imaging Sciences, Emory University School of Medicine, 1364 Clifton Road NE, Atlanta, GA 30322, USA. - - 2011
Phase analysis of gated single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) is an evolving technique for measuring LV mechanical dyssynchrony. Since its inception in 2005, it has undergone considerable technical development and clinical evaluation. This article reviews the background, the technical and clinical characteristics, and evolving clinical applications ...
Kleijn Sebastiaan A - - 2011
In an era of rapidly expanding and evolving 3-dimensional echocardiographic (3DE) technology, 1 of the issues facing the 3DE quantification of chamber volumes and function is that different software vendors use different methodologies and algorithms. The aim of this study was to evaluate the comparability and reproducibility of 3DE direct ...
Bhyri Channappa - - 2011
An important factor to consider when using findings on electrocardiograms for clinical decision making is that the waveforms are influenced by normal physiological and technical factors as well as by pathophysiological factors. In this paper, we propose a method for the feature extraction and heart disease diagnosis using wavelet transform ...
Qian Z - - 2011
CT-based coronary artery calcium (CAC) scanning has been introduced as a low-radiation imaging technique for the assessment of the overall coronary arterial atherosclerotic burden. A three dimensional CAC volume contains significant clinically relevant information, which is unused by conventional whole-heart CAC quantification methods. In this paper, we have developed a ...
Kühl Susanne J - - 2011
During regeneration, lost functional tissue can, in general, be replaced by different mechanisms, including proliferation of terminally differentiated cells or through differentiation of resident stem cells. It is a well-accepted dogma that the mammalian heart cannot efficiently regenerate upon injury as a consequence of insufficient oxygen supply. This is in ...
Beller George A - - 2011
Basic knowledge of active and passive transport mechanisms for concentrating monovalent cations in myocardial cells led to the investigation of the application of radioisotopes of potassium, thallium, rubidium, and ammonia to the in vivo noninvasive assessment of regional myocardial perfusion and viability utilizing gamma camera or positron emission tomographic (PET) ...
Susin Francesca Maria - - 2011
As with all mechanical prostheses, bileaflet heart valves are prone to thrombus formation, reduced hemodynamic performance, and the occurrence of embolic events. The early detection of thrombotic formations is crucial for correct diagnosis and adequate therapy. The study aim was to analyze the power spectra of the phonocardiographic signals acquired ...
Trinkmann Frederik - - 2011
BACKGROUND: When assessing the function of the cardiovascular system, cardiac output (CO) is a substantial parameter. For its determination, numerous non-invasive techniques have been proposed in the recent years including inert gas rebreathing (IGR) and impedance cardiography (ICG). The aim of our study was to evaluate whether a novel ICG ...
Attin Mina - - 2011
Prevention of cardiac complications including death is influenced by the availability of diagnostic tools and technological advances. Cardiac telemetry as a diagnostic tool is widely used in hospitals because of an increased severity of illness and complex modality of treatments. QTc interval abnormalities in the electrocardiogram have been long recognized ...
Auger Dominique - - 2011
Triplane tissue synchronization imaging (TSI) and real-time 3-dimensional echocardiography (RT3DE) provide different characterizations of left ventricular (LV) mechanics and dyssynchrony. Triplane TSI assesses differences in time to peak systolic segmental myocardial tissue velocities, whereas RT3DE evaluates differences in time to minimum end-systolic regional volumes. Whether an approach using the 2 ...
Hotta Viviane Tiemi - - 2011
BACKGROUND: Echocardiography is a useful method for screening and assessing response to cardiac resynchronization therapy (CRT). 3D echocardiography has already established its role in the evaluation of ventricular volumes and ejection fraction (LVEF) with excellent correlation of results when compared with MRI. OBJECTIVE: To compare the evaluation of ventricular volumes ...
de Mello Ricardo Andrade Fernades - - 2011
OBJECTIVE: To evaluate the diagnostic performance of stress perfusion cardiac MR (CMR) for detecting significant CAD (≥70% narrowing) in comparison with invasive coronary angiography (ICA) as a reference standard. METHODS: Examinations of 54 patients who underwent both stress perfusion CMR and ICA for investigation of CAD between 2007 and 2009 ...
Lim Phang Boon PB Cardiology Department, Imperial College Healthcare NHS Trust, St Mary's Hospital, Praed Street, London, W2 1NY, UK. - - 2011
This study aims to evaluate a method to detect heart rate variability (HRV) changes using short ECG segments during ablation for arrhythmias. HRV was averaged from sequentially shorter time windows from 5-min ECG recordings in 15 healthy volunteers. The 40-s window was identified as the shortest duration that yielded reproducible ...
Kujala Ville J - - 2011
Extracellular field potential (FP) recordings with microelectrode arrays (MEAs) from cardiomyocyte cultures offer a non-invasive way of studying the electrophysiological properties of these cells at the population level. Several studies have examined the FP properties of cardiomyocytes of various origins, including stem cell-derived cardiomyocytes. This focus reflects growing importance and ...
Mavrogeni Sophie - - 2011
Cardiovascular magnetic resonance (CMR) is a noninvasive, nonradiating imaging technique, which provides novel information for the evaluation of cardiovascular diseases. Until now it has been successfully used for the evaluation of congenital and acquired heart diseases, cardiac tumors-mass, iron overload, and myocardial fibrosis detection. Recently, its diagnostic capabilities have been ...
Peng Chaoquan C Department of Cardiology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China. - - 2013
This study was designed to investigate the effects of treatment with autologous mesenchymal stem cells (MSCs) by intracoronary transplantation on myocardial infarction (MI) in swine. MSCs were transfected with a lentiviral vector carrying the gene encoding green fluorescent protein (GFP) and labeled in vitro with superparamagnetic iron oxide (SPIO). An ...
Bradley S M - - 2011
Despite the passage of 50 years since the introduction of closed chest compression and mouth-to-mouth rescue breathing as the techniques of modern cardiopulmonary resuscitation (CPR), the simple techniques remain the backbone of successful resuscitation of victims of cardiac arrest. In particular, the importance of high quality chest compressions is increasingly ...
Brugaletta Salvatore - - 2011
The aim of this study was to compare the findings of near-infrared spectroscopy (NIRS), intravascular ultrasound (IVUS) virtual histology (VH), and grayscale IVUS obtained in matched coronary vessel segments of patients undergoing coronary angiography. Intravascular ultrasound VH has been developed to add tissue characterization to the grayscale IVUS assessment of ...
Petersen John W JW University of Florida College of Medicine, Gainesville, Florida, - - 2011
Global left ventricular (LV) ejection fraction (LVEF) has been used as a measure of improvement in LV function following cell therapy. Although the impact of cell therapy on LVEF in short- and long-term follow-up has been generally positive, there is concern that research evaluating regional therapeutics (e.g., cell or gene ...
Cheng Yi - - 2011
Real-time label-free electrical detection of proteins, including cardiac troponin (cTn), is demonstrated using functionalized SnO(2) nanobelt field-effect transistors (FETs) with integrated microfluidics. Selective biomolecular functionalization of the active SnO(2) nanobelt channel and effective passivation of the substrate surface were realized and verified through fluorescence microscopy. The validation/verification of the sensing ...
Sorrell Vincent L - - 2011
Objective: Precise estimation of wall motion abnormalities during routine echocardiography rests on optimal endocardial border visualization. Endocardial "dropout" may result in the misinterpretation of regional wall motion. Left ventricular opacification (LVO) with intravenous contrast improves the visualization of the left ventricular endocardial border length (EnBL). The purpose of this study ...
Voros Szilard - - 2011
Coronary computed tomography angiography (CTA) allows coronary artery visualization and the detection of coronary stenoses. In addition; it has been suggested as a novel, noninvasive modality for coronary atherosclerotic plaque detection, characterization, and quantification. Emerging data show that coronary CTA-based semiquantitative plaque characterization and quantification are sufficiently reproducible for clinical ...
Varvarousi G - - 2011
The vast majority of laboratory studies on animals have focused on ventricular fibrillation (VF) and not on cardiac arrest (CA) resulting from asphyxia. The aim of this study was to develop a clinically relevant animal model in Landrace/Large-White swine of asphyxial CA resuscitated using the European Resuscitation Council guidelines. Survival ...
Sasson Comilla - - 2011
To understand the association between neighborhood and individual characteristics in determining whether or not bystanders perform cardiopulmonary resuscitation (CPR) in cases of out-of-hospital cardiac arrest (OHCA). Between October 1, 2005 to November 30, 2008, 1108 OHCA cases from Fulton County (Atlanta), GA, were eligible for bystander CPR. We conducted multi-level ...
Liakopoulos Oliver J - - 2011
To determine if cardiopulmonary bypass (CPB), together with inhibition of the sodium-hydrogen exchanger (NHE), limits myocardial and neurological injury and improves recovery after prolonged (unwitnessed) cardiac arrest (CA), as NHE inhibition improved recovery after deep hypothermic circulatory arrest. Twenty-seven pigs (31-39 kg) underwent 15 min of prolonged (no-flow) CA followed ...
Zhang Youhua - - 2011
Enhancing vagal tone by delivering electrical stimulation to the vagal nerves (VNS) is emerging as a promising novel therapy in heart failure. In addition, VNS is already an FDA-approved therapy for refractory epilepsy and depression. Besides its well-known negative chronotropic, inotropic, and dromotropic effects, VNS has profound effects on cardiac ...
Shah Atman P - - 2011
Clinical administration of bone marrow-derived stem cells in the setting of acute myocardial infarction (AMI) leads to improved left ventricular ejection fraction. Thymosin beta-4 (TB4) and vascular endothelial growth factor (VEGF) are linked to adult epicardial progenitor cell mobilization and neovascularization and is cardioprotective after myocardial ischemia. This study investigated ...
Wong Sally Cheukying - - 2011
We describe a patient who was admitted to the hospital with a community-acquired pneumonia complicated by new-onset atrial fibrillation. She suffered a cardiac arrest while having her lunch. The arrest had followed accidental aspiration of food (a piece of boiled swede [sweet potato]) in the hospital. There was no past ...
Beslic Nermina - - 2011
Early detection of coronary artery disease is one of the prerequisites for adequate and successful treatment of patients and because of that it is important to assess which diagnostic method in a certain time gives the most reliable data to define the optimal medical treatment. The study included 100 subjects. ...
Wang Jinnan - - 2011
The aim of this study was to explore the feasibility and reproducibility of a time-efficient coronary vessel wall measurement approach using an improved motion-sensitized driven equilibrium (iMSDE) pulse sequence. In this study, the iMSDE pulse sequence was first optimized and then applied on a group of healthy volunteers (N = 10) to ...
Lønborg Jacob - - 2011
Late gadolinium enhancement (LGE) and T2-weighted cardiovascular magnetic resonance (CMR) provides a means to measure myocardial area at risk (AAR) and salvage. Several T2-weighted CMR sequences are in use, but there is no consensus in terms of which sequence to be the preferred. Therefore, the aim of the present study ...
Akbari Mohammad Ali - - 2011
During the cardiac cycle, the heart normally produces repeatable physiological sounds. However, under pathologic conditions, such as with heart valve stenosis or a ventricular septal defect, blood flow turbulence leads to the production of additional sounds, called murmurs. Murmurs are random in nature, while the underlying heart sounds are not ...
Singleman Corinna - - 2011
Zebrafish have become a beneficial and practical model organism for the study of embryonic heart development, however, work examining post-embryonic through adult cardiac development has been limited. Examining the changing morphology of the maturing and aging heart are restricted by the lack of techniques available for staging and isolating juvenile ...
Huang Chih-Sheng CS Brain Research Center and Institute of Electrical Control Engineering, National Chiao Tung University, Hsinchu, - - 2011
Myocardial infarction (MI), generally known as a heart attack, is one of the top leading causes of mortality in the world. In clinical diagnosis, cardiologists generally utilize 12-lead ECG system to classify patients into MI symptoms: 1. ST segment elevation, 2. ST segment depression or T wave inversion. However unstable ...
Kwon Sungjun S Interdisciplinary Program of Bioengineering, Seoul National University, Seoul 110 799, Korea. Sjkwon@ - - 2011
Ubiquitous medical technology may provide advanced utility for evaluating the status of the patient beyond the clinical environment. The iPhone provides the capacity to measure the heart rate, as the iPhone consists of a 3-axis accelerometer that is sufficiently sensitive to perceive tiny body movements caused by heart pumping. In ...
Vaizurs Raja Sarath Chandra Prasad RS Department of Electrical Engineering, College of Engineering, University of South Florida, - - 2011
Atrial Fibrillation, a common arrhythmia accompanied by an increased morbidity and mortality remains difficult to treat either with medications or invasive procedures. Targeted destruction of atrial fibrillation triggers offers the best hope for permanent resolution of the arrhythmia. In this work, identification of atrial triggers is based on the analysis ...
Laing Genevieve G Mechanical Engineering, Boston University, Boston, MA 02215, USA. - - 2011
Replacing open-heart surgical procedures with beating-heart interventions substantially decreases the trauma and risk of a procedure. One of the most challenging procedures to perform on the beating heart is valve repair. To address this need, this paper proposes a tool for replacing mitral valve chordae to correct regurgitation. The chordae ...
Radhakrishnan Jeejabai - - 2011
We compared the efficacy of the novel sodium-hydrogen exchanger (NHE-1) inhibitor AVE4454B with cariporide for resuscitation from ventricular fibrillation (VF) assessing the effects on left ventricular myocardial distensibility during chest compression, myocardial function after the return of spontaneous circulation, and survival. Three groups of 10 rats each were subjected to ...
Gupta Shuchita - - 2010
The incidence of non-ST elevation myocardial infarction (NSTEMI) is increasing. Although life-threatening ventricular arrhythmias have been well-documented in patients with ST elevation MI (STEMI), their incidence and importance in NSTEMI have not been examined in similar detail. We examined the incidence, predictors, and mortality rates of ventricular arrhythmias in a ...
Matta Mary J - - 2010
The successful management of fetal arrhythmias is contingent on an accurate diagnosis of arrhythmia and its effects on fetal well-being. Regardless of the rate (tachycardia or bradycardia) or rhythm (regular or irregular), the diagnosis of arrhythmia by Doppler echocardiography is based on the atrioventricular relationship and the atrial and ventricular ...
Kitamura Tetsuhisa - - 2011
Little is known about the effect of the type of bystander-initiated cardiopulmonary resuscitation (CPR) for prolonged out-of-hospital cardiac arrest (OHCA). To evaluate the time-dependent effectiveness of chest compression-only and conventional CPR with rescue breathing for witnessed adult OHCA of cardiac origin. A nationwide, prospective, population-based, observational study of the whole ...
Mountantonakis Stavros - - 2012
Cardiac arrhythmias including atrial fibrillation, ventricular tachycardia, and ventricular fibrillation are important causes of cardiovascular morbidity and mortality. Although they usually occur in the setting of structural heart disease, these arrhythmias can be the primary manifestation of subclinical cardiovascular disease and have deleterious consequences including stroke, heart failure, and death. ...
Kelly J - - 2011
Sudden cardiac death is the most common cause of mortality in young athletes. In some of these, the final pathway is arrhythmia. The authors aimed to identify the incidence, diagnosis and management of athletes undergoing investigation and intervention for cardiac arrhythmias. Retrospective analysis of all patients between 10 and 17 ...
Pazoki Raha - - 2010
Sudden cardiac death (SCD) is a leading cause of total and cardiovascular mortality, and ventricular fibrillation is the underlying arrhythmia in the majority of cases. In the young, where the incidence of SCD is low, a great proportion of SCDs occur in the context of inherited disorders such as cardiomyopathy ...
Weiss James N JN UCLA Cardiovascular Research Laboratory, Departments of Medicine (Cardiology), Physiology and Integrative Biology and Physiology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA. - - 2010
Early afterdepolarizations (EADs) are an important cause of lethal ventricular arrhythmias in long QT syndromes and heart failure, but the mechanisms by which EADs at the cellular scale cause arrhythmias such as polymorphic ventricular tachycardia (PVT) and torsades de pointes (TdP) at the tissue scale are not well understood. Here ...
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