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Eslami Maryam M 1Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, - - 2014
Heart valve-related disorders are among the major causes of death worldwide. Although prosthetic valves are widely used to treat this pathology, current prosthetic grafts cannot grow with the patient while maintaining normal valve mechanical and hemodynamic properties. Tissue engineering may provide a possible solution to this issue through using biodegradable ...
Radwan-Oczko MaƂgorzata M Department of Periodontology; Unit of Oral Pathology; Wroclaw Medical University; Wroclaw, - - 2014
Background There is evidence that advanced infectious chronic periodontal inflammatory disease may have an impact on general health including cardiovascular diseases. The aim of this clinical study was to evaluate the ability of Porphyromonas gingivalis to colonize heart valves and, subsequently, to assess whether there is an association between the ...
Kandasamy Ashok A Department of Cardiothoracic Anesthesia, SRM Medical College Hospital and Research Centre, SRM University, Chennai, Tamil Nadu, - - 2014
We describe postoperative refractory ventricular tachycardia (VT) in a patient following aortic and mitral valve replacement. Following an uneventful separation from cardiopulmonary bypass with dobutamine, the patient developed recurrent VT, 4 hours into the postoperative period. The VT did not respond to standard doses of xylocard, magnesium and amiodarone. Electrolyte ...
Rantala Sari - - 2014
Cardiac device-related endocarditis is a very rare clinical manifestation of S. dysgalactiae subsp. equisimilis disease. This pathogen is a common cause of cellulitis. We here report two cases of cardiac device-related endocarditis due to Streptococcus dysgalactiae subsp. equisimilis. Blood cultures yielded this pathogen and both patients had recurrent bacteremia. Transthoracic ...
Jana S S Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, - - 2014
Tissue engineered heart valves offer a promising alternative for the replacement of diseased heart valves avoiding the limitations faced with currently available bioprosthetic and mechanical heart valves. In the paradigm of tissue engineering, a three-dimensional platform - the so-called scaffold - is essential for cell proliferation, growth, and differentiation as ...
Nakamura Yuki Y Department of Cardiovascular Surgery, Ehime University Hospital, Shitsukawa, Toon, Ehime, 791-0295, Japan, - - 2014
Hereditary hemorrhagic telangiectasia (HHT) is caused by an autosomal dominant gene and characterized by multiple arteriovenous malformations in several organs, leading to bleeding or shunting. These patients often suffer severe infections and heart failure, which should be managed in the perioperative period, when open heart surgery is indicated. We report ...
Abhaichand Rajpal K RK Department of Cardiology, GKNM Hospital, Coimbatore, - - 2014
Balloon mitral valvotomy is a commonly performed procedure for mitral stenosis. This procedure can lead to complications such as left ventricular perforation with tamponade, mitral regurgitation and stroke. Here we report a case of left ventricular pseudoaneurysm following balloon mitral valvotomy. It was a consequence of adherent pericardium secondary to ...
Fiedler K A - - 2014
There is little evidence on the optimal mode of clopidogrel discontinuation. Epidemiological studies observed clustering of thrombotic events after cessation of chronic clopidogrel therapy. The underlying mechanism has been ascribed to transient platelet hyper-reactivity. Gradual tapering of clopidogrel may have the potential to attenuate this phenomenon. The objective of the ...
Nozohoor Shahab S Department of Cardiothoracic Surgery, Anesthesia and Intensive Care, Skane University Hospital, Lund University, Lund, - - 2014
Several types of valves and valved conduits have been developed for right ventricular outflow tract reconstruction and yet no one has provided prolonged satisfactory hemodynamic performance. The RVOT Elan is a bioprosthetic heart valve conduit constructed from a vascular graft and a porcine stentless valve indicated specifically for right ventricular ...
Weinstein Jean Marc JM Cardiology Department, Soroka University Medical Center, PO Box 151, Beer-Sheva, Israel. - - 2014
There is much debate on the pathogenesis of ischemic mitral regurgitation (MR), usually related to global or regional left ventricular dysfunction or remodeling secondary to chronic ischemic changes, altering the tethering and closing forces on the mitral apparatus. There is a paucity of literature describing MR in the setting of ...
Ye Ying Y Cleveland Clinic Lerner College of Medicine, Cleveland, - - 2014
The study objective was to investigate whether, in patients undergoing surgery for degenerative mitral valve disease, associated right ventricular remodeling and dysfunction are stronger determinants of preoperative organ dysfunction and prognosis than functional tricuspid regurgitation. From January 2001 to January 2011, 4197 patients underwent primary mitral valve surgery for degenerative ...
Fujita Tomoyuki T Department of Cardiovascular Surgery, National Cerebral and Cardiovascular Centre, Osaka, - - 2014
Although right heart failure (RVF) is an important issue in the management of patients with left ventricular assist devices (LVADs), the benefits of performing tricuspid valve repair in conjunction with LVAD implantation have not been demonstrated. We retrospectively reviewed the records of 141 patients who received LVAD implantation as a ...
Deja Marek A MA 2nd Department of Cardiac Surgery, Medical University of Silesia, Katowice, - - 2014
It remains unclear why some patients with cardiomyopathy secondary to anterior infarction do, and others do not develop functional mitral regurgitation (MR). Thirty-six patients after anterior infarction with ejection fraction (EF) of below 35%, 18 with no/trivial and 18 with moderate/severe MR, underwent cardiac magnetic resonance imaging. Parameters describing the ...
Tanaka Daizo D Daizo Tanaka, Shinya Unai, James T Diehl, Hitoshi Hirose, Division of Cardiothoracic Surgery, Department of Surgery, Thomas Jefferson University, Philadelphia, PA 19107, United - - 2014
Left ventricular (LV) thrombus is a life-threatening complication of severe LV dysfunction. Ventriculotomy has been a commonly performed procedure for LV thrombus; however, it often further decrease LV function after surgery. We present an alternative approach to thrombectomy in order to minimize the postoperative LV dysfunction. A 37-year-old female with ...
Adelstein Evan E Heart and Vascular Institute, Cardiology Department, University of Pittsburgh Medical Center, Pittsburgh, - - 2014
Echocardiography-guided left ventricular (LV) lead placement at the site of latest mechanical activation improves heart failure outcomes in patients receiving a cardiac resynchronization therapy defibrillator (CRT-D). In this study, we test the hypothesis that a strategy of echocardiography-guided LV lead placement improves patient survival rate free from appropriate CRT-D therapy ...
Adriaanse B M E BM Department of Obstetrics and Gynecology, VU University Medical Center, Amsterdam, The Netherlands; Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The - - 2014
The differential insertion of the atrioventricular valves is the ultrasonographic representation of the more apical attachment of the tricuspid valve to the septum with respect to the mitral valve. A linear insertion is present when both valves form a linear continuum and is suggested as a marker for atrioventricular septal ...
Zeng Xin X Cardiac Ultrasound Laboratory, Massachusetts General Hospital, Boston, - - 2014
Ischemic mitral regurgitation (IMR) results from mitral leaflet tethering from left ventricular remodeling. Heterogeneity in local or global left ventricular remodeling can result in differential tethering patterns and affect mitral valve function and the degree of mitral regurgitation. The aims of this study were to compare mitral valve geometry in ...
Van Nooten Guido J GJ Department of Cardiac Surgery, University of Ghent, Ghent, Belgium. Electronic address: - - 2014
Since May 1992 the Medtronic Open Pivot mechanical heart valve has been implanted routinely at the authors' institution. The study aim was to analyze, retrospectively, the 20-year clinical results of the valve. Between May 1992 and December 2011 a total of 1,520 valves was inserted into 1,382 consecutive patients (1,012 ...
Wang Tom Kai Ming TK Green Lane Cardiovascular Service, Auckland City Hospital, Auckland, New Zealand. Electronic address: - - 2014
Right heart endocarditis makes up 5-10% of all infective endocarditis involving valvular, congenital and artificial structures. Given the limited literature in this area, we reviewed the characteristics, management and outcomes of this condition in this retrospective cohort study. Thirty-five patients with right heart endocarditis admitted to Auckland City Hospital during ...
Esposito Giampiero G Department of Cardiac Surgery, Humanitas Gavazzeni Hospital, Bergamo, - - 2014
Tethering of both mitral leaflets is the predominant mechanism of mitral regurgitation in patients with chronic ischaemic cardiomyopathy. For patients with severe mitral leaflet tethering, we have developed a surgical approach alternative to the conventional undersized annuloplasty ring that targets the subvalvular apparatus and aims to reconstitute the leaflet coaptation ...
Adigopula Sasikanth - - 2014
ACC Stage C heart failure includes those patients with prior or current symptoms of heart failure in the context of an underlying structural heart problem who are primarily managed with medical therapy. Although there is guideline-based medical therapy for those with heart failure with reduced ejection fraction (HFrEF), therapies in heart ...
Parry Dominic D Department of Cardiovascular Surgery, Peter Munk Cardiac Centre, Toronto General Hospital, Toronto, Ontario, Canada. Electronic address: - - 2014
Aortic valve disease in the setting of a left ventricular assist device presents unique challenges. We present the case of a patient who underwent transcatheter aortic valve implantation to replace a stenotic aortic valve to facilitate left ventricular assist device explantation. Thirty-three days later, the porcine pericardial valve cusps were ...
Abdallah Mouin S MS Saint Luke's Mid America Heart Institute, Kansas City, Missouri; University of Missouri-Kansas City, Kansas City, Missouri. Electronic address: - - 2014
Intensive statin therapy is a central component of secondary prevention after acute myocardial infarction (AMI), particularly among high-risk patients, such as those with diabetes mellitus (DM). However, the frequency and predictors of intensive statin therapy use after AMI among patients with DM have not been described. We examined patterns of ...
Denti Paolo P San Raffaele University Hospital, Via Olgettina, 60, 20100, Milan, Italy, - - 2014
The natural history of severe mitral regurgitation (MR) is unfavorable, leading to left ventricular failure, atrial fibrillation, stroke, and death. Many patients affected by severe regurgitation (MR) do not currently undergo surgery, mainly due to the perceived risk of the procedure (old age, impaired left ventricular function, and comorbidities). Mitral ...
Masoumi Nafiseh N Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 65 Landsdowne Street, Cambridge, MA, 02139, USA; Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, MA, 02115, USA; Department of Cardiac, Surgery Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA, 02115, USA; Department of Bioengineering, The Pennsylvania State University, 205 Hallowell Building, State College, PA, 16801, - - 2014
Tissue engineered heart valves (TEHV) can be useful in the repair of congenital or acquired valvular diseases due to their potential for growth and remodeling. The development of biomimetic scaffolds is a major challenge in heart valve tissue engineering. One of the most important structural characteristics of mature heart valve ...
Manji Rizwan A RA Department of Surgery, University of Manitoba, Winnipeg, MB, Canada; Cardiac Sciences Program, Winnipeg Regional Health Authority and St. Boniface Hospital, Winnipeg, MB, - - 2014
Glutaraldehyde-fixed bioprosthetic heart valves (GBHVs), derived from pigs or cows, undergo structural valve deterioration (SVD) over time, with calcification and eventual failure. It is generally accepted that SVD is due to chemical processes between glutaraldehyde and free calcium ions in the blood. Valve companies have made significant progress in decreasing ...
Caspar Thibault T Department of Cardiology, University Hospital of Strasbourg, Strasbourg, - - 2014
We report a very rare case of a 43-year-old patient with fatal left ventricular subepicardial aneurysm rupture complicating embolic myocardial infarction due to mitral valve infective endocarditis.
Oueida Farouk F Cardiac Surgery Department, Saud Al-Babtain Cardiac Centre, Dammam, Saudi - - 2014
Atrial fibrillation is the most common form of arrhythmia in mitral valve disease. Radiofrequency ablation is most commonly used for atrial fibrillation ablation during mitral valve surgery. This prospective study evaluated the midterm outcomes of intraoperative radiofrequency atrial fibrillation ablation during mitral valve surgery. 52 patients were eligible for the ...
Xu Sheng-Song SS Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Anhui Medical University, Cardiovascular Disease Research Center of Anhui Medical University, Hefei, - - 2014
Aortic-left ventricular tunnel is a rare congenital cardiac anomaly, which always arises from the right coronary sinus and enters the left ventricle, occasionally the right ventricle and right atrium. However, aortic and left ventricular tunnel associated with infective endocarditis is rarely seen in literatures. Here, we present a case of ...
Punnoose Lynn L Division of Cardiology, Weill Cornell Medical College, New York, NY. Electronic address: - - 2014
Functional mitral regurgitation is a highly prevalent condition among patients with ischemic and dilated cardiomyopathies. Arising from remodeling of both the mitral valve annulus and left ventricle, it is associated with high mortality and morbidity. In select patients, cardiac resynchronization therapy helps reduce functional mitral regurgitation, but surgical intervention remains ...
Roselli Eric E EE Departments of Thoracic and Cardiovascular Surgery and Interventional Cardiology, Heart and Vascular Institute, The Cleveland Clinic, Cleveland, Ohio. Electronic address: - - 2014
Transcatheter aortic valve replacement (TAVR) expands options for high-risk patients with aortic stenosis but is complex with life-threatening complications. We describe indications for use of salvage cardiopulmonary bypass (CPB) and assess outcomes. From 2006 to 2011, 303 patients underwent TAVR, and 12 (4%) required emergency CPB. Approach was transapical (9) ...
Hoffmann Rainer R Department of Cardiology, Pneumology, Angiology and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany. Electronic address: - - 2014
Percutaneous mitral valve repair using the MitraClip device has become a therapeutic alternative for high surgical risk patients with symptomatic mitral regurgitation. The procedure involves transseptal puncture and results in a new atrial septal defect (ASD) after withdrawal of the 22Fr guiding catheter. The functional effect of the new ASD ...
Rogers Jason H JH aDivision of Cardiovascular Medicine, UC Davis Medical Center, Sacramento, California bUniversity of Michigan Cardiovascular Center, University of Michigan, Ann Arbor, Michigan, - - 2014
Functional tricuspid regurgitation (FTR) is an important clinical entity that is encountered frequently during the operative management of left-sided heart valve disease, particularly in the setting of mitral regurgitation. Failure to recognize the importance of FTR during mitral valve surgery may result in inferior early and late outcomes because of ...
Al-Atassi Talal T aDivision of Cardiac Surgery, University of Ottawa bDepartment of Epidemiology and Community Medicine, University of Ottawa, Ottawa, - - 2014
This review describes new developments in mitral valve interventions for patients with heart failure. The review also discusses innovative therapies in the treatment of mitral regurgitation in patients with heart failure and describes novel risk factors of recurrent mitral regurgitation following repair in this population. Percutaneous strategies are rapidly emerging ...
Ertl Georg G Medizinische Klinik 1/Deutsches Zentrum für Herzinsuffizienz, Würzburg, - - 2014
Heart failure has become a worldwide epidemic of the 21st century with increasing impact on healthcare systems. The 2012 ESC and 2013 ACCF/AHA guidelines have set the stage for current therapy to reduce mortality and morbidity. There is a dawn of hope for therapy of acute and diastolic heart failure; ...
Rim Yonghoon - - 2014
Ischemic mitral valve (MV) is a common complication of pathologic remodeling of the left ventricle due to acute and chronic coronary artery diseases. It frequently represents the pathologic consequences of increased tethering forces and reduced coaptation of the MV leaflets. Ischemic MV function has been investigated from a biomechanical perspective ...
Du Dongxing - - 2014
Mitral valve (MV) edge-to-edge repair (ETER) is a surgical procedure for the correction of mitral valve regurgitation by suturing the free edge of the leaflets. The leaflets are often sutured at three different positions: central, lateral and commissural portions. To study the effects of position of suture on left ventricular ...
Ibrahim Michael - - 2014
The discovery of substantial myocardial improvement following the mechanical unloading afforded by left ventricular assist device (LVAD) therapy challenged the dogma of heart failure being irreversible. Since then, a significant experience with the use of LVAD therapy as a bridge to recovery has accumulated. The discovery of substantial structural and ...
Young Amelia - - 2014
Nonsurgical treatment of clinically important mitral regurgitation (MR) has evolved tremendously over the past decade. Recent studies of percutaneous mitral valve repair procedures have shown that less invasive procedures are safe and can be effective in selected patients. MitraClip has been studied most extensively. The MitraClip is attached to the ...
Le Huu Alice A Division of Cardiac Surgery & Surgical Research, Department of Surgery, The Royal Victoria Hospital, McGill University Health Center, 687 Pine Avenue West, Suite S8.73b, Montreal, Quebec, H3A 1A1, - - 2014
 The prevalence of valvular heart disease is expected to increase in the coming decades, with an associated rise in valve-related surgeries. Current options for valve prostheses remain limited, essentially confined to mechanical or biological valves. Neither selection provides an optimal balance between structural integrity and associated morbidity. Mechanical valves offer ...
Bayya Praveen Reddy - - 2014
Severe mitral regurgitation (MR) following balloon mitral valvotomy (BMV) needing emergent mitral valve replacement is a rare complication. The unrelieved mitral stenosis is compounded by severe MR leading to acute rise in pulmonary hypertension and right ventricular afterload, decreased coronary perfusion, ischemia and right ventricular failure. Associated septal shift and ...
Dayan Victor V Centro Cardiovascular, Hospital de Clinicas, Facultad de Medicina, Montevideo, Uruguay. Electronic address: - - 2013
Ischemic mitral regurgitation (IMR) occurs in 20% of patients after myocardial infarction. There is no agreement as to the best surgical option. With no prospective randomized controlled trials available, our objective was to perform a meta-analysis comparing replacement and repair. A literature search was performed in PubMed, EMBASE, Ovid, and Google ...
Ray McCarthy Lígia Pereira Bre - - 2013
Despite the significant advances in cardiac surgery, heart valve replacement still faces a dilemma. While mechanical valves offer lifelong durability they also commit patients to anticoagulation treatment for the rest of their life. On the other hand, bioprosthetic valves have superior hemodynamic performance but durability of the bioprosthesis limits their ...
Brittain Evan L EL Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tenn. Electronic address: - - 2013
The optimal management of mitral regurgitation (MR) in patients with cardiomyopathy has been controversial. Minimally invasive fibrillating mitral valve replacement (mini-MVR) might limit postoperative morbidity and mortality by minimizing recurrent MR. We hypothesized that mini-MVR with complete chordal sparing would offer low mortality and halt left ventricular (LV) remodeling in patients ...
Estevez-Loureiro R R Interventional Cardiology Unit Division of Cardiology Complejo Asistencial Universitario de Leon Fundación Investigación Sanitaria Leon (FISLeon) Leon, Spain - - - 2013
Mitral valve regurgitation (MR) is a frequent condition usually associated with heart failure and reduced survival. Surgery remains the gold standard treatment but a significant number of patients are not optimal candidates due to age, comorbidities or poor left ventricular function. In this subgroup of patients transcatheter mitral interventions have ...
Su Boyang B Biofluid Mechanics Research Laboratory, 2 Engineering Drive 3, Department of Bioengineering, National University of Singapore, 117576 Singapore, Singapore; Cardiac Mechanics Engineering and Physiology Unit, National Heart Centre Singapore, Mistri Wing 17, 3rd Hospital Avenue, 168752 Singapore, - - 2013
Intraventricular flow is important in understanding left ventricular function; however, relevant numerical simulations are limited, especially when heart valve function is taken into account. In this study, intraventricular flow in a patient-specific left ventricle has been modelled in two-dimension (2D) with both mitral and aortic valves integrated. The arbitrary Lagrangian-Eulerian ...
Emmert Maximilian Y - - 2013
Valvular heart disease represents a leading cause of mortality worldwide. Transcatheter heart valve replacement techniques have been recently introduced into the clinical routine expanding the treatment options for affected patients. However, despite this technical progress toward minimally invasive, transcatheter strategies, the available heart valve prostheses for these techniques are bioprosthetic ...
Godinho Ana Rita - - 2013
The authors present a rare case of subacute endocarditis caused by Gemella morbillorum. A 72-year-old man, with a history of hypertension, aortic valve disease and upper and lower endoscopy six months previously, was admitted due to fever and abdominal pain. He also complained of long-standing dyspnea on exertion and petechiae ...
Ducas Robin A RA University of Manitoba, Winnipeg, Manitoba, Canada. Electronic address: - - 2014
Functional mitral regurgitation (FMR) is a challenging clinical entity that frequently complicates ischemic and nonischemic cardiomyopathy. The underlying pathophysiology of FMR is caused primarily by ventricular and subvalvular apparatus dysfunction which causes failure of proper leaflet coaptation. Echocardiography is the primary modality used in diagnosis and characterization of FMR. Echocardiography ...
Kondruweit Markus - - 2013
High-speed camera examination of heart valves is an established technique to examine heart valve prosthesis. The aim of this study was to examine the possibility to transmit new tools for high-speed camera examination of heart valve behavior under near-physiological conditions in a porcine ex vivo beating heart model. After explantation ...
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