Search Results
Results 251 - 300 of 2946
< 1 2 3 4 5 6 7 8 9 10 11 >
Levack Melissa M - - 2012
Proponents of flexible annuloplasty rings have hypothesized that such devices maintain annular dynamics. This hypothesis is based on the supposition that annular motion is relatively normal in patients undergoing mitral valve repair. We hypothesized that mitral annular dynamics are impaired in ischemic mitral regurgitation and myxomatous mitral regurgitation. A Philips ...
Otani Kyoko K Second Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, - - 2012
In patients with mitral valve prolapse, nonprolapsed leaflets are often apically tented. We hypothesized that secondary left ventricular dilatation attributed to primary mitral regurgitation (MR) causes papillary muscle (PM) displacement, resulting in this leaflet tenting/tethering, and that secondary tethering further exacerbates malcoaptation and contributes to MR severity. Three-dimensional transesophageal echocardiography ...
Jackson Shaun P - - 2012
Antiplatelet agents have become the cornerstone pharmacological therapy for the acute coronary syndromes (ACS). Used in combination with percutaneous coronary intervention, antithrombotic therapy has had a major positive impact on outcomes in this patient group [1-3]. The relatively high frequency of recurrent thrombosis with single antiplatelet therapy has necessitated the ...
Gatti Giuseppe - - 2012
Chronic ischemic mitral regurgitation (IMR) is associated with asymmetric mitral leaflet tethering and annular dilation. The Carpentier-McCarthy-Adams IMR ETlogix annuloplasty ring is designed specifically to treat these asymmetric pathological changes. In the present study, the results of mitral annuloplasty with this ring in a selected subset of patients with significant ...
Overend Louise - - 2012
Embolic myocardial infarction is an uncommon but increasingly recognised complication of infective endocarditis. This complication has a high mortality rate and is deemed a relative contraindication to thrombolytic therapy. The present article describes an episode of acute myocardial infarction associated with infective endocarditis. Systemic thrombolytic therapy was administered, which resulted ...
McCann Patrick - - 2012
Inotropic therapy remains an option in the management of patients with advanced heart failure symptoms from systolic dysfunction who do not respond to conventional therapies. The decision to use this class is largely predicated on an accurate evaluation of the patient's fluid and perfusion status. Selection of the appropriate agent ...
Bochard-Villanueva Bruno - - 2012
Acquired left ventricular-right atrial communication ( Gerbode-type defect) is a rare complication of infective endocarditis. Although transesophageal echocardiography remains the technique of choice for the evaluation of complications of endocarditis this case highlights the usefulness of cardiac computed tomography in this scenario, particularly in cases where assessment of coronary anatomy ...
Quick Esther - - 2013
Mitral valve annulus calcification is a degenerative cardiac condition often found at autopsy in the elderly. While usually considered incidental to the cause of death, we report two cases where mitral valve annulus calcification with valve stenosis was associated with sudden death. Case 1: a 61-year-old female who had underlying ...
Tong Betty C BC Division of Thoracic and Cardiovascular Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA. - - 2012
Coronary revascularization trials often use a composite endpoint of major adverse cardiac and cerebrovascular events (MACCE). The usual practice in analyzing data with a composite endpoint is to assign equal weights to each of the individual MACCE elements. Noninferiority margins are used to offset effects of presumably less important components, ...
Demir Fikri - - 2012
Left ventricular noncompaction (LVNC) is a rare cardiomyopathy. It usually presents with ventricular dysfunction, thromboembolic events and arrhythmias. An asymptomatic clinical course is also possible. LVNC is frequently associated with other congenital heart diseases including heart valve abnormalities. The coexistence of LVNC with double-orifice mitral valve was observed rarely. The ...
Beauchamp-Irizarry Ana - - 2012
Despite improvements in care, up to one-third of patients presenting with ST-elevation myocardial infarction (STEMI) within 12 hours of symptom onset receive no reperfusion therapy. Despite effective pre- and in-hospital reperfusion strategies becoming standard over the past two decades, time-to-admission and time-to-treatment remains prolonged. Prompt reperfusion treatment is essential to ...
Grothoff Matthias M Department of Diagnostic and Interventional Radiology, University of Leipzig-Heart Center, Struempellstrasse 39, Leipzig, Germany. - - 2013
Patients with a congenitally corrected transposition of the great arteries show an increasing incidence of cardiac failure with age. In other systemic right ventricles, such as in dextro-transposition after atrial switch, excessive hypertrophy is a potential risk factor for impaired systolic function. In this trial, we sought to compare systemic ...
Bonou Maria - - 2012
Prosthetic valve thrombosis is a potentially life-threatening complication associated with high morbidity and mortality. Transthorasic and transoesophageal echocardiography play an important role to the diagnosis and provides incremental information about the optimal treatment strategy, while fluoroscopy and cardiac computed tomography may be of added value. Guidelines differ on whether surgical ...
Karantalis Vasileios - - 2012
Although pharmacological and interventional advances have reduced the morbidity and mortality of ischemic heart disease, there is an ongoing need for novel therapeutic strategies that prevent or reverse progressive ventricular remodeling following myocardial infarction, the process that forms the substrate for ventricular failure. The development of cell-based therapy as a ...
Carrick Richard R College of Medicine of the University of Vermont, Burlington, Vermont, - - 2012
We sought to determine regional myofiber stress after Coapsys device (Myocor, Inc, Maple Grove, MN) implantation using a finite element model of the left ventricle (LV). Chronic ischemic mitral regurgitation is caused by LV remodeling after posterolateral myocardial infarction. The Coapsys device consists of a single trans-LV chord placed below ...
Pantin Enrique J - - 2012
To perform minimally invasive cardiac surgery through the smallest possible wound and with the least number of incisions in the heart or aorta, the necessary cannulations to undergo cardiopulmonary bypass must be done through peripheral vessels. A difficult skill to learn for the cardiac anesthesiologist is how to safely and ...
Kortsmit Jeroen - - 2012
An emerging therapy to limit adverse heart remodelling following myocardial infarction (MI) is the injection of polymers into the infarcted left ventricle (LV). In the few numerical studies carried out in this field, the definition and distribution of the hydrogel in the infarcted myocardium were simplified. In this computational study, ...
Rady Mohamed Y - - 2012
Left ventricular assist devices (LVADs) and total artificial hearts (TAHs) are surgically implanted as permanent treatment of unrecoverable heart failure. Both LVADs and TAHs are durable mechanical circulatory support (MCS) devices that can prolong patient survival but also alter end-of-life trajectory. The permissibility of discontinuing assisted circulation is controversial because ...
Loor Gabriel - - 2012
Temporary right ventricular (RV) support is considered during insertion of a left ventricular assist device in patients who are at risk of right ventricular dysfunction. There are several circuits and cannulation strategies available. Here, we report an effective and safe method for achieving RV support using the RotaFlow (Maquet) extracorporeal ...
Boccaccio Antonio - - 2012
Abstract Left ventricular assist devices (LVADs) work as a bypass between the left ventricular apex and the ascending aorta. The surgical procedure for their insertion requires the opening of the cardiac cavities and the dissection of the great vessels, the blood is constrained to flow through the device components and ...
Dolla William Jacob S - - 2012
Thin cap fibroatheroma (TCFA) in coronary arteries is believed to be associated with plaque rupture leading to cardiovascular death and non-fatal myocardial infarction. Catheter-based imaging platforms can identify TCFAs but detection algorithms lack specificity. Here we report results of an exploratory study of the variability in TCFA plaque attributes and ...
Ashikaga H - - 2012
The aim of the present study was to validate area change ratio (%AC) against myofiber shortening (%ë f) in the heart in vivo. %AC is emerging as a mechanical index that may approximate %ë f by incorporating both circumferential and longitudinal shortening. However, the physiological significance of %AC remains unclear. ...
Wenk Jonathan F JF Department of Mechanical Engineering, University of Kentucky, Lexington, Kentucky, - - 2012
The temporal progression in extent and severity of regional myofiber contractile dysfunction in normally perfused border zone (BZ) myocardium adjacent to a myocardial infarction (MI) has been shown to be an important pathophysiologic feature of the adverse remodeling process in large animal models. We sought, for the first time, to ...
Meredith Ian T - - 2012
OBJECTIVES: This study sought to compare the safety and efficacy of 2 dose formulations of SYNERGY, a novel bioabsorbable polymer everolimus-eluting stent (EES) (Boston Scientific Corp., Natick, Massachusetts) compared with the durable polymer PROMUS Element EES. BACKGROUND: Durable polymer coatings on drug-eluting stents have been associated with chronic inflammation and ...
Liu Nian N Cardiovascular Genetic Program, The Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, NY 10016, - - 2012
Recent studies have shown that flecainide may be an effective therapy to prevent life-threatening arrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia. Several hypotheses have been advanced to explain the antiarrhythmic mechanism of flecainide, including Na(+) channel blockade and a direct inhibitory action on the ryanodine receptor. In this article, ...
Kinsara Abdulhalim Jamal - - 2012
We are reporting a patient who sustained a large myocardial infarction with large kissing thrombi in echocardiogram that disappeared within 1 month without the administration of thrombolytic, anticoagulation or antiplatelet therapy. The patient did not manifest any embolic events. This unusual course calls for specific studies on the natural history of ...
Hunter Ross J - - 2012
BACKGROUND: -Atrial stretch causes remodeling that predisposes to atrial fibrillation (AF). We tested the hypothesis that peaks in left atrial (LA) wall stress are associated with focal remodeling. METHODS AND RESULTS: -19 patients underwent LA mapping prior to catheter ablation for persistent AF. Finite Element Analysis was used to predict ...
Hiesinger William W Division of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, PA, - - 2012
Ventricular remodeling after myocardial infarction begins with massive extracellular matrix deposition and resultant fibrosis. This loss of functional tissue and stiffening of myocardial elastic and contractile elements starts the vicious cycle of mechanical inefficiency, adverse remodeling, and eventual heart failure. We hypothesized that stromal cell-derived factor 1α (SDF-1α) therapy to ...
Yamada Shoko Merrit - - 2012
OBJECTIVE: For long-term preservation of ventriculo-peritoneal (VP) shunt function, it is essential to place the ventricular catheter tip above the foramen of Monro. But the free-hand technique for ventricular catheter passage is not consistent. METHODS: Supposing that a convex of skull matches to a sphere, in which the foramen of ...
Ganeshpure Swapnil - - 2012
A 76&emsp14;-year-old lady with a recent diagnosis of rheumatic heart disease (RHD), and a history of repeated lower respiratory tract infections, came with symptoms of gastritis unrelated to the primary disease but further diagnostic study in the hospital revealed poorly controlled atrial fibrillation, grossly dilated left atrium with two large ...
König Fabian F Chair of Medical Engineering, Technical University Munich, Boltzmannstrasse 15, Garching 85748, Germany. - - 2012
Heart valve disease (HVD) is a globally increasing problem and accounts for thousands of deaths yearly. Currently end-stage HVD can only be treated by total valve replacement, however with major drawbacks. To overcome the limitations of conventional substitutes, a new clinical approach based on cell colonization of artificially manufactured heart ...
Toufan Mehrnoush - - 2012
We describe a 73-year-old male patient with left ventricular noncompaction (LVNC) who was diagnosed with acute myocardial infarction (MI), three-vessel coronary artery disease, a fresh intraventricular thrombus, and mitral regurgitation. He was treated with full anticoagulant therapy, coronary artery bypass grafting, and mitral valve repair. This case adds to a ...
Shiraishi Y Y Department of Medical Engineering and Cardiology, Institute of Development and Cancer, Tohoku University, Sendai 980-8575, Japan. - - 2012
Annuloplasty for functional mitral or tricuspid regurgitation has been made for surgical restoration of valvular diseases. However, these major techniques may sometimes be ineffective because of chamber dilation and valve tethering. We have been developing a sophisticated intelligent artificial papillary muscle (PM) by using an anisotropic shape memory alloy fiber ...
Dohmen P M - - 2012
Several prostheses are available to replace degenerative diseased aortic valves with unique advantages and disadvantages. Bioprotheses show excellent hemodynamic behavior and low risk of thromboembolic complications, but are limited by tissue deterioration. Mechanical heart valves have extended durability, but permanent anticoagulation is mandatory. Tissue engineering created a new generation heart ...
Misfeld Martin - - 2012
With the ever-increasing popularity of minimally invasive (MI) cardiac surgery, procedures like aortic valve replacement, with or without concomitant aortic surgery, and mitral and tricuspid valve procedures are now routinely performed through a minimal-access partial upper sternotomy and right anterolateral small thoracotomy, respectively, in our institution. To have optimal visualization ...
Christou C C Cumberland Infirmary, Carlisle, - - 2012
We present what maybe the only case of splenic infarction causing hyperamylasaemia in a patient with bacterial endocarditis. A 49-year-old gentleman presented a 24 hour history of vomiting, abdominal pain and fever. Clinical examination showed diffuse upper abdominal tenderness, a mild tachycardia and a low grade pyrexia. Blood investigations showed ...
White Matt A - - 2012
New skeletal elements are reported of the holotype specimen Australovenator wintonensis, from the type locality, near Winton, central western Queensland. New elements include left and right humeri, right radius, right radiale, right distal carpal 1, near complete right metacarpal I, left manual phalanx II-1, left manual phalanx II-2, near complete ...
Mega Jessica - - 2012
Antithrombotic therapy plays an essential role in the management of some of the most common and morbid medical conditions. Triple oral antithrombotic therapy (TOAT) is defined as the administration of both therapeutic oral anticoagulation (OAC) and dual antiplatelet therapy (DAPT) to patients with indications for both treatments. The current societal ...
Tavakolian Kouhyar K Centre for Integrative Bioengineering Research (CiBER), School of Engineering Science, Simon Fraser University, Burnaby, BC, Canada V5A 1S6. - - 2012
A seismocardiography based methodology is introduced for predicting the start and the end of diastole to be used in diastolic timed vibrations. An accelerometer was placed on the sternum of 142 participants (120 healthy and 22 ischemic heart patients) to record Seismocardiogram (SCG). It is claimed that SCG, in combination ...
Zhang Zhihong Z Department of Surgery, University of California San Francisco San Francisco, CA, - - 2012
Contractile function in the normally perfused infarct borderzone (BZ) is depressed. However, the impact of reduced BZ contractility on left ventricular (LV) pump function is unknown. As a consequence, there have been no therapies specifically designed to improve BZ contractility. We tested the hypothesis that an improvement in borderzone contractility ...
Cagri Aykan A - - 2012
The risk of systemic embolisation in patients with prosthetic heart valves who are receiving anticoagulation therapy is 0.5 to 1.7% per patient year and most cases present with cerebrovascular events. Here we report the case of a 42-year-old woman who was uneventfully treated with a low dose, prolonged infusion of ...
Niemeijer Nicolasine D - - 2012
We describe a patient with acute cardiogenic shock due to cardiac involvement in idiopathic hypereosinophilic syndrome (Löffler endocarditis). At the echocardiography, there was a huge mass in the left ventricular cavity, resulting in inflow- and outflow tract obstruction. The posterior leaflet of the mitral valve apparatus was completely embedded in ...
Leong Darryl P - - 2011
Purpose: Right ventricular (RV) systolic function as measured by right ventricular ejection fraction (RVEF) has long been recognized as an important predictor of outcome in heart failure patients. The echocardiographic measurement of RV volumes and RVEF is challenging, however, owing to the unique geometry of the right ventricle. Several nonvolumetric ...
Castillo Javier G JG Department of Cardiothoracic Surgery, The Mount Sinai Medical Center, New York, United - - 2011
In the western world, the prevalence of mitral regurgitation-particularly that due to degenerative disease-has gradually increased despite a substantial decrease in rheumatic disease. If present, secondary ventricular dysfunction, potentially irreversible when clinically diagnosed, requires close echocardiographic follow-up in order to establish a subclinical diagnosis. Thus, echocardiography has become an essential ...
Centofanti Paolo - - 2011
We present our technique for the implantation of the Jarvik 2000 left ventricular assist device (Jarvik Heart, Inc, New York, NY) without cardiopulmonary bypass by the induction of rapid pacing that allows the insertion of the apical device into the left ventricle, minimizing blood loss and surgical complications. Although the ...
Sachdeva Ritu - - 2011
Left ventricular (LV) pseudoaneurysm is rare in children. This report describes the case of a 2-year-old previously healthy girl who was diagnosed with endocarditis and underwent resection of a large mitral valve vegetation from the posterior mitral leaflet. One month after this surgery, she was diagnosed with a large LV ...
Choi Hon Fai - - 2011
Left-ventricular remodeling is considered to be an important mechanism of disease progression leading to mechanical dysfunction of the heart. However, the interaction between the physiological changes in the remodeling process and the associated mechanical dysfunction is still poorly understood. Clinically, it has been observed that the left-ventricle often undergoes large ...
Cingolani Oscar H - - 2011
Nearly 40 years ago, the Sagawa laboratory spawned a renaissance in the use of instantaneous ventricular pressure-volume relations to assess cardiac function. Since then, this analysis has taken hold as the most comprehensive way to quantify ventricular chamber function and energetics, and cardiac-vascular interactions. First studied in large mammalian hearts ...
Kloner Robert A - - 2011
The no-reflow phenomenon relates to the inability to reperfuse regions of the myocardium after ischemia, despite removal of the large epicardial coronary artery occlusion. The mechanism involves microvascular obstruction. In experimental studies, using markers for flow (thioflavin S, carbon black, microspheres), perfusion defects associated with no-reflow demonstrated ultrastructural evidence of ...
Ko Sheung-Fat - - 2011
: To investigate the effects of immediate intramyocardial implantation of autologous bone marrow-derived mononuclear cells (BMDMNCs) in minipig myocardium after coronary artery ligation with magnetic resonance imaging (MRI), histopathologic, and immunochemical studies. : Of the 12 minipigs subjected to permanent left anterior descending coronary artery ligation, 6 were immediately treated ...
< 1 2 3 4 5 6 7 8 9 10 11 >