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Noble Stephane S Cardiology Service, Department of Medical Specialties, University Hospital of Geneva 4, Rue Gabrielle Perret-Gentil 1211 Geneva 14, - - 2014
Hypertrophic cardiomyopathy (HCM) is characterized as left ventricular hypertrophy unexplained by abnormal loading conditions. Approximately 30% of patients with HCM will develop left ventricular outflow obstruction under resting conditions. In the 5-10% of patients with drug-refractory symptoms, surgical septal myectomy has been shown to reduce outflow obstruction and relieve symptoms; ...
Song Jae-Kwan JK Cardiac Imaging Center, Asan Medical Center Heart Institute, University of Ulsan College of - - 2014
Left ventricular outflow tract obstruction (LVOTO) has important prognostic implications in patients with hypertrophic cardiomyopathy (HCM). Echocardiography provides critical information to establish LVOTO as a unique feature of HCM by demonstrating heterogeneity of hypertrophy patterns and the systolic anterior motion of mitral leaflets, resulting in mitral-septal contact. Currently, 2 treatment ...
Li Shoujun S Pediatric Cardiac Surgery Center, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Disease and Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, People's Republic of China. Electronic address: - - 2014
The study objective was to report the outcomes of biventricular repair in patients with double outlet right ventricle. Patients with double outlet right ventricle who underwent biventricular repair at Fuwai Hospital from January 2005 to December 2012 were included. Patients were excluded if double outlet right ventricle was combined with ...
Lim Hong-Gook HG Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul, Republic of - - 2014
To overcome the drawbacks of the Rastelli operation, the modified Lecompte procedure creates a connection from the left ventricle to the aorta with greater freedom from residual obstruction due to the resection of the outlet septum and avoids the implantation of an extracardiac valved conduit. We evaluated the effectiveness of ...
Liang Jj J Department of Medicine, Mayo Clinic, Rochester, MN, USA - - 2014
Patients with apical ballooning syndrome may develop dynamic left ventricular outflow obstruction due to systolic anterior motion of the mitral valve leaflet and secondary functional mitral regurgitation, causing decreased cardiac output and hypotension. If suspected, bedside echocardiography will quickly confirm this complication. Positive inotropic/chronotropic agents should be avoided as they ...
Xu Zhen Z Medical College of Hebei University of Engineering, 056002, Handan, Hebei Province, P. R. - - 2014
A new species of ascaridoid nematode, Hysterothylacium gibsoni sp. nov., is described based on specimens collected from the intestine of the slender lizardfish Saurida elongata (Temminck et Schlegel) (Aulopiformes: Synodontidae) in the Yellow Sea, China. The new species differs from its congeners by its small body size (12.8-13.2 mm), the ...
Hermens Jeannine A J M JA Department of Cardiology, Thoraxcentrum Twente, Medisch Spectrum Twente, Haaksbergerstraat 55, 7513 ER, Enschede, The Netherlands, - - 2014
Patients with acute chest pain, electrocardiographic ST-elevation and significant elevation of cardiac troponin but without obstructive coronary artery disease represent a diagnostic and therapeutic dilemma. Cardiac magnetic resonance imaging (CMR) can elucidate underlying alternative causes of troponin elevation including detection of (minor) myocardial infarction (MI) by identifying myocardial scarring as ...
Sirois Caroline C Department of Nursing, UQAR , Lévis , - - 2014
Introduction. The benefit of aspirin in primary prevention of myocardial infarction and the associated gastro-intestinal bleeding risks have not been well established in the elderly population with diabetes. Methods. Using Quebec administrative databases, we conducted two nested case-control analyses within a cohort of individuals aged ≥ 66 years newly treated ...
Nakazato Ryo R Department of Cardiology, St Luke's International Hospital, Tokyo, - - 2014
Prior studies evaluating the prognostic utility of cardiac CT angiography (CCTA) have been largely constrained to an all-cause mortality endpoint, with other cardiac endpoints generally not reported. To this end, we sought to determine the relationship of extent and severity of coronary artery disease (CAD) by CCTA to risk of ...
Fujimoto Shinichiro S Department of Cardiology, Takase Clinic, Takasaki, Japan, - - 2014
Existing methods to calculate pre-test probability of obstructive coronary artery disease (CAD) have been established using selected high-risk patients who were referred to conventional coronary angiography. The purpose of this study is to develop and validate our new method for pre-test probability of obstructive CAD using patients who underwent coronary ...
Basir Mir Babar MB Cardiology Fellow, Henry Ford Hospital, Detroit, - - 2014
We report a novel approach in which successful unjailing of the septal perforator was performed through the side branch of a coronary stent using a rotational atherectomy device for the purpose of alcohol septal ablation in a patient with symptomatic hypertrophic obstructive cardiomyopathy. © 2014 Wiley Periodicals, Inc.
Dougoud Svetlana S Cardiac Imaging, University Hospital Zurich, Ramistrasse 100, NUK C 42, 8091, Zurich, - - 2014
Long term follow-up of coronary CT angiography (CCTA) is scarce. The aim of the present study was to assess the prognostic value of CCTA over a follow-up period of more than 6 years. 218 Patients were included undergoing 64-slice CCTA. Images were analysed with regard to the presence of nonobstructive (<50 %) or ...
Varma Praveen Kerala PK Department of Cardiac Surgery, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, - - 2014
Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiovascular disease with many genotype and phenotype variations. Earlier terminologies, hypertrophic obstructive cardiomyopathy and idiopathic hypertrophic sub-aortic stenosis are no longer used to describe this entity. Patients present with or without left ventricular outflow tract (LVOT) obstruction. Resting or provocative LVOT obstruction ...
Zhang Ling L Departments of aNuclear Medicine bCardiology, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, - - 2014
This study was designed to evaluate the left ventricular myocardial perfusion and function in hypertrophic obstruction cardiomyopathy patients following percutaneous transluminal septal myocardial ablation (PTSMA) using rest single-photon emission computed tomography (SPECT) myocardial perfusion imaging. Thirty-five patients (24 men and 11 women, 48±11 years old) with hypertrophic obstruction cardiomyopathy underwent ...
Malik Rabiya R Cardiovascular Center, Tufts Medical Center, Tufts University School of Medicine, Boston, - - 2014
Obstruction of the right ventricular outflow tract (RVOT) is a rare finding in hypertrophic cardiomyopathy (HCM) patients unlike left ventricular outflow tract (LVOT) obstruction. Although there are guidelines that aid in clinical decision making in patients with LVOT obstruction, there are none addressing RVOT obstruction. As RVOT obstruction may pose ...
Kobayashi Taisei T Heart and Vascular Institute, Cleveland Clinic, Cleveland, - - 2014
Patients with obstructive hypertrophic cardiomyopathy (HC) have various left ventricular (LV) shapes: reverse septal curvature (RSC, commonly familial), sigmoid septum (SS, common in hypertensives), and concentric hypertrophy (CH). Longitudinal (systolic and early diastolic) strain rate (SR) is sensitive in detecting regional myocardial dysfunction. We sought to determine differences in longitudinal ...
Sunbul Murat M Department of Cardiology, Faculty of Medicine, Marmara University, Istanbul, - - 2014
Hypertrophic obstructive cardiomyopathy (HOCM) is characterized by left ventricular hypertrophy of various morphologies, with variety of clinical manifestations and hemodynamic dysfunctions. Myocardial bridge (MB) is frequently seen in HOCM patients and the decrease of flow in the coronary artery segment going intramurally through the myocardium beneath a muscle bridge is ...
Avegliano Gustavo G aCardiac Imaging Department, Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina bCenter for Computational Imaging and Simulation Technologies in Biomedicine, Universitat Pompeu Fabra cCetir Sant Jordi dCentro Cardiovascular Sant Jordi eInstitució Catalana de Recerca i Estudis Avançats, Barcelona, - - 2014
Hypertrophic cardiomyopathy (HCM) is a disease with marked genetic and phenotypic heterogeneity. It is well known that obstructive septal forms of this disease entail worse clinical outcome compared with nonobstructive septal and apical forms. The objective of this study was to analyze the differences in left ventricular diastolic function in ...
Iqbal Sohah N SN Cardiovascular Clinical Research Center, Department of Medicine, New York University School of Medicine, New York, - - 2014
In a prospective study, we previously identified plaque disruption (PD: plaque rupture or ulceration) in 38% of women with myocardial infarction (MI) without angiographically obstructive coronary artery disease (CAD), using intravascular ultrasound (IVUS). Underlying plaque morphology has not been described in these patients and may provide insight into the mechanisms ...
Kato Masafumi M Division of Cardiology, Mie Heart Center, 2227-1, Ohyodo, Meiwa, Takigun, Mie, 515-0302, Japan, - - 2014
Although percutaneous transluminal septal myocardial ablation (PTSMA) has been the established treatment of symptomatic patients with hypertrophic obstructive cardiomyopathy (HOCM), the efficacy for specific HOCM is not elucidated. We report a successful case of PTSMA for heart failure with severe left ventricular outflow tract (LVOT) obstruction due to sigmoid-shaped interventricular ...
Bittencourt Marcio Sommer MS 1Non-Invasive Cardiovascular Imaging Program, Departments of Medicine and Radiology; Brigham and Women's Hospital; Harvard Medical School, Boston, MA; Heart Institute - University of São Paulo, São Paulo, - - 2014
-The contribution of plaque extent to predict cardiovascular (CV) events among patients with non-obstructive and obstructive coronary artery disease (CAD) is not well defined. Our objective was to evaluate the prognostic value of plaque extent detected by coronary computed tomography (CTA). -All consecutive patients without prior CAD referred for coronary ...
Bouabdallaoui Nadia N Department of Cardiology, Georges Pompidou European Hospital, - - 2014
Takotsubo cardiomyopathy (TTC) is a well-recognised entity that commonly manifests with chest pain, ST segment abnormalities and transient left ventricular apical ballooning without coronary artery obstructive disease. This syndrome usually portends a favourable outcome. In the rare haemodynamically unstable TTC patients, acute mitral regurgitation (MR) related to systolic anterior motion ...
Xu Hua-Yan HY Department of Radiology, National Key Laboratory of Biotherapy, West China Hospital, Sichuan University, 37# Guo Xue Xiang, Chengdu, Sichuan 610041, - - 2014
To assess regional myocardial microvascular dysfunction differences in hypertrophic cardiomyopathy (HCM) patients with or without left ventricular outflow tract obstruction using 3.0-T cardiac magnetic resonance (CMR) first-pass perfusion imaging. Forty-two HCM patients, including 25 HCM patients with left ventricular outflow tract obstruction (HOCM), 17 HCM patients without left ventricular outflow ...
Overman David M DM Division of Cardiovascular Surgery, The Children's Heart Clinic, Children's Hospitals and Clinics of Minnesota, Minneapolis, MN. Electronic address: - - 2014
Left ventricular outflow tract obstruction (LVOTO) is an important source of morbidity and mortality after repair of atrioventricular septal defect (AVSD). The intrinsic anatomy of the left ventricular outflow tract in AVSD is complex and predisposes to the development of LVOTO. LVOTO after repair of AVSD usually involves multiple levels ...
Trevino Alejandro R AR Houston Methodist DeBakey Heart & Vascular Center, Houston Methodist, Houston, - - 2014
Hypertrophic cardiomyopathy is a relatively common genetic disorder and usually asymptomatic. However, approximately 25% of patients develop left ventricular outflow obstruction and can develop angina, syncope, or congestive heart failure. Initiation and titration of beta-blockade usually results in symptomatic improvement. Patients with medically refractory symptoms can see further symptomatic improvement ...
Kim Sang-Hoon SH Department of Cardiology, CHA Bundang Medical Centre, CHA University, Seongnam, - - 2014
A 54-year-old male presented with symptoms of dyspnoea, and oedema of the lower extremities. Transthoracic echocardiography (TTE) revealed secondum-type atrial septal defect (ASD). He successfully received a 30-mm Amplatzer ASD closure device percutaneously. Echocardiography immediately after the procedure and the next day showed a wellpositioned device. He was discharged the ...
Crea Filippo F Department of Cardiovascular Sciences, Institute of Cardiology, Catholic University of the Sacred Heart, 00187 L.go Vito 1, Roma, - - 2013
Many patients undergoing coronary angiography because of chest pain syndromes, believed to be indicative of obstructive atherosclerosis of the epicardial coronary arteries, are found to have normal angiograms. In the past two decades, a number of studies have reported that abnormalities in the function and structure of the coronary microcirculation ...
Reynolds Harmony R HR Cardiovascular Clinical Research Center, Leon H. Charney Division of Cardiology, Department of Medicine, NYU Langone Medical Center, 530 First Ave, Skirball 9R, New York, NY 10016, USA. Electronic address: - - 2013
Angiography in patients with myocardial infarction (MI) most commonly reveals one or more significantly narrowed coronary arteries, but a substantial minority of patients with spontaneous MI have no obstructive coronary artery disease (CAD) at angiography. This review summarizes evidence for the most commonly hypothesized mechanisms, including plaque disruption, plaque erosion, ...
Hainstock Michael R - - 2013
BACKGROUND: ANGIOPLASTY AND STENT PLACEMENT IN RIGHT VENTRICLE-TO-PULMONARY ARTERY (RV-PA) CONDUITS HAVE BEEN SHOWN TO PROLONG THE FUNCTIONAL LIFESPAN OF A CONDUIT. SAFETY AND EFFICACY OF ANGIOPLASTY OF OBSTRUCTED RV-PA HOMOGRAFTS USING ULTRA-NONCOMPLIANT (UNC) OR ULTRAHIGH-PRESSURE BALLOONS ARE UNKNOWN.METHODS AND RESULTS: FROM 2004 TO 2012, 70 PATIENTS UNDERWENT 76 PROCEDURES ...
Kang Seonghui - - 2013
Dynamic left ventricular outflow tract obstruction with or without mitral regurgitation is typically observed in hypertrophic cardiomyopathy, but is also occasionally seen without left ventricular hypertrophy. In this report, we present a case of cardiogenic shock that mimics ST-elevation myocardial infarction, due to dynamic left ventricular outflow tract obstruction with ...
Rao Carmelo Massimiliano - - 2013
Accessory mitral valve (AMV) is an extremely uncommon congenital cardiac anomaly and it is a rare cause of left ventricular outflow tract (LVOT) obstruction. Identification of asymptomatic patients with LVOT obstruction is uncommon since the symptoms usually become manifest when the gradient across the LVOT rises. We describe a rare ...
Infusino Fabio - - 2013
Guidelines report that the optimal treatment for ST-elevation myocardial infarction (STEMI) is a primary percutaneous coronary intervention (PPCI) when performed timely by trained operators. Yet, the reopening of the infarct-related artery (IRA) is not always followed by myocardial reperfusion. This phenomenon is most commonly called "no-reflow", is caused by microvascular ...
Chen Marcus Y - - 2013
Vasodilator stress cardiac magnetic resonance (CMR) detects ischemia whereas coronary CT angiography (CTA) detects atherosclerosis. The purpose of this study was to determine concordance and accuracy of vasodilator stress CMR and coronary CTA in the same subjects. We studied 151 consecutive subjects referred to detect or exclude suspected obstructive coronary ...
Bhat Pradeep K - - 2013
Apical ballooning syndrome (ABS) and obstructive coronary artery disease of the left anterior descending coronary artery (LAD) can both result in similar left ventricular apical wall motion abnormalities. The right ventricle may more likely be involved in ABS, and its careful evaluation may help differentiate the two conditions. Therefore, the ...
Cheng Allen - - 2013
With HeartMate II (HMII) implants increasing so has the frequency of device exchange. However, identifying inflow cannula obstruction, pump thrombosis, or outflow obstruction as the mechanism of pump dysfunction can be difficult. Echocardiography, CT angiogram, and cardiac catheterization are not definitive in determining the location of pump failure. Therefore, intraoperative ...
De Cocker Laurens J L - - 2013
Background: Very small cerebellar infarcts (diameter <2 cm) are a frequent finding on MRI. With an increasing scientific interest in cerebral microinfarcts, very small infarcts in the cerebellum deserve more of our attention as well. The goal of the present article was to review infarct terminology and mechanisms, as well ...
Curzen Nicholas - - 2013
Acute ST-segment elevation myocardial infarction (STEMI) is a dynamic, thrombus-driven event. As understanding of its pathophysiology has improved, the central role of platelets in initiation and orchestration of this process has become clear. Key components of STEMI include formation of occlusive thrombus, mediation and ultimately amplification of the local vascular ...
Chan Wah Hak Y S - - 2013
Nonsurgical septal reduction by coil embolisation of the first major septal branch was successfully performed in a 34-year-old patient with hypertrophic obstructive cardiomyopathy, resulting in acute reduction of left ventricular outflow tract obstruction and symptomatic improvement. Follow-up at 18 months showed sustained clinical and echocardiographic benefits from the procedure. To ...
Puymirat E - - 2013
Percutaneous coronary intervention (PCI) of small coronary vessels represents a real challenge for myocardial revascularization because of the high risk of stent-restenosis and increased risk of adverse clinical events. Moreover, small coronary arteries supply small myocardial territories therefore questioning the clinical significance of small-vessel stenoses. The definition of small-vessel disease ...
Poonja Zia - - 2013
We present images of an endobronchial hamartoma visible by bronchoscopy in the left lower lobe. A 56-year-old woman with a late presentation of an acute anterior myocardial infarction requires urgent heart transplantation and subsequently has trouble weaning off the ventilator. Bronchoscopic evaluation reveals a 1cm endobronchial hamartoma obstruction the left ...
Kim Dongmin - - 2013
Occurrence of dynamic left ventricular outflow tract (LVOT) obstruction is not infrequent in critically ill patients, and it is associated with potential danger. Here, we report a case of transient heart failure with hemodynamic deterioration paradoxically induced by extreme dehydration. This article describes clinical features of the patient and echocardiographic ...
Williams Lynne - - 2013
Hypertrophic cardiomyopathy (HCM) has been one of the most interesting and controversial disorders in cardiovascular medicine. Although initial descriptions of the pathology of hypertrophic cardiomyopathy (HCM) were published over a century ago, it was not until the surgical and pathological observations of Brock and Teare respectively that this cardiac entity ...
Alam Mohammed S - - 2013
OBJECTIVE: To determine if increased epicardial adipose tissue (EAT) measured by cardiac CT could be associated with impaired myocardial flow reserve (MFR) in patients with non-obstructive coronary artery disease (CAD). BACKGROUND: Studies have shown that EAT volume is related to epicardial obstructive CAD, myocardial ischemia and major adverse cardiac events. ...
Hein Thet - - 2013
Abstract Background: Relationship between obstructive sleep apnoea and atherosclerosis has not been confirmed using coronary angiography. We sought to investigate the relationships between the apnoea-hypopnoea index (AHI) and angiographic coronary disease phenotypes. 
Methods: SYNTAX score, lesion complexity, and thrombus burden grade were determined in 125 patients presenting with acute myocardial ...
Ahn Kye Taek - - 2013
A subaortic membrane is an uncommon cause for left ventricular outflow tract obstruction. Hypertrophic cardiomyopathy with dynamic left ventricular outflow tract obstruction would mask the presence of the subaortic membrane on transthoracic echocardiography and cause a false diagnosis. We report a patient with subaortic stenosis due to flail subaortic membrane ...
De Ferrari Gaetano M GM Department of Cardiology, Fondazione IRCCS Policlinico San Matteo, Pavia, - - 2014
Limited data exist concerning outcomes of patients with non-ST-segment elevation acute coronary syndromes (NSTE ACS) with no angiographically obstructive coronary artery disease (non-obstructive CAD). We assessed the frequency of clinical outcomes among patients with non-obstructive CAD compared with obstructive CAD. We pooled data from eight NSTE ACS randomized clinical trials ...
Tesic Milorad - - 2013
OBJECTIVE: To evaluate, by noninvasive coronary flow velocity reserve (CFVR), whether patients with asymmetric hypertrophic cardiomyopathy (HC), with or without left ventricular outflow tract obstruction, demonstrate significant regional differences of CFVR. METHODS: We evaluated 61 patients with HC (27 men; mean age 49 ± 16 years), including 20 patients with ...
Wyrick Sara - - 2013
This study aimed to report on a toddler who presented with progressively worsening abdominal pain and obstructive uropathy 1 week after ureteral valve reimplantation. Acute renal failure resulted in critical hyperkalemia. Chart review of presentation, physical examination, laboratory tests, and treatment. Initial potassium level was 10 mEq/L; ventricular tachycardia was ...
Szardien Sebastian - - 2013
Stress cardiomyopathy is a form of reversible systolic dysfunction of the mid and apical left ventricle with pathologic changes of the electrocardiogram in the absence of an obstructive coronary artery disease. The prevalence of stress cardiomyopathy among patients with symptoms suggestive of myocardial infarction is 0.7% to 2.5%, and it ...
Tano Ayako - - 2013
BACKGROUND: A sigmoid ventricular septum (SVS) may be related to normal aging, but some people with an SVS develop a left ventricular outflow tract (LVOT) obstruction (defined as a gradient of >30mmHg). Therefore, we investigated the association of LVOT obstructions with an SVS by dobutamine stress echocardiography (DSE) and assessed ...
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