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Cimmino Giovanni - - 2011
The structural secuelae of acute myocardial infarction (AMI) is mostly dictated by left ventricular (LV) remodelling, leading to heart failure. Monocyte chemoattractant protein-1 (MCP-1), matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) play a critical role in LV remodelling. β-blockers are first line therapy for AMI and heart failure; however, ...
Neizel Mirja - - 2010
OBJECTIVES: This study evaluated the value of systolic and diastolic deformation indexes determined by strain-encoded imaging to predict persistent severe dysfunction at follow-up in patients after reperfused acute myocardial infarction (AMI) in comparison with late gadolinium enhancement (LGE). BACKGROUND: Animal studies suggest that regional diastolic function provides information about myocardial ...
Taniguchi Norimasa - - 2010
Erythropoietin (EPO) enhances re-endothelialization and anti-apoptotic action. Larger clinical studies to examine the effects of high-dose EPO are in progress in patients with acute myocardial infarction (AMI). The aim of this multi-center pilot study was to investigate the effect of `low-dose EPO' (6,000 IU during percutaneous coronary intervention (PCI), 24 h ...
Pereg David - - 2011
Acute stress is increasingly recognized as a precipitant of acute myocardial infarction (AMI). However, the role of chronic stress in developing AMI is less clear. We have developed a method to measure cortisol in hair, which allows longitudinal assessment of cortisol levels prior to an acute event. We aimed to ...
Kälsch H - - 2010
Cardiac toxicity is a known side effect of chemotherapeutics such as 5-fluorouracil (5-FU) or cisplatin. Chest pain with ECG changes, arrhythmias, acute myocardial infarction (AMI), heart failure and sudden death have been described in the literature. We report the first case of AMI in a 59-year-old male patient with chronic ...
Providência Rui - - 2011
Background Fast and effective diagnosis of patients with acute myocardial infarction (AMI) in the Emergency Department (ED) is needed. Manchester Triage (MT) is based on identification of the patient's main complaint, establishing, through decision flowcharts, a target-time for first observation. This study aimed to evaluate the impact of MT on ...
Kim Weon - - 2010
The purpose of this study was to determine the clinical and laboratory characteristics in patients with acute myocardial infarction (AMI) associated with coronary vasospasm. Consecutive 231 patients with documented coronary vasospasm by ergonovine provocation test but with a normal-appearing coronary angiogram were divided into two groups, variant angina pectoris (VAP) ...
Peterson Eric D - - 2010
The NCDR ACTION Registry-GWTG collects detailed in-hospital clinical, process-of-care and outcomes data for patients admitted with acute myocardial infarction (AMI) in the USA. The registry is a national AMI surveillance system that contributes to the scientific enquiry process of AMI care through the facilitation of local and national quality improvement ...
Barth Julian H - - 2010
BACKGROUND: It has long been an accepted belief that serum cholesterol significantly falls after myocardial infarction and that a return to pre-event levels takes approximately 3 months. The magnitude and clinical significance of this fall has recently been challenged. METHODS: In the Secondary Prevention of Acute Coronary Events-Reduction Of Cholesterol ...
Park Seong-Mi - - 2011
Objectives: This study was to evaluate the longitudinal and radial function of the left- and right-side ventricular septum (Ls and Rs) in patients with acute anterior myocardial infarction (AMI) by tissue Doppler imaging. Methods: Thirty patients with anterior ST-elevation AMI and revascularization and 20 age-matched normal subjects were enrolled as ...
Kelly Dominic - - 2010
Alterations in the balance of matrix metalloproteinase to tissue inhibitor of metalloproteinase (TIMP) are seen after acute myocardial infarction (AMI) and are associated with adverse left ventricular remodeling and prognosis in this setting. We aimed to investigate the association between TIMP levels and the occurrence of major adverse cardiac events ...
Kopec Grzegorz - - 2011
Effective management of acute myocardial infarction (AMI) is limited by patient delay in calling an ambulance. We aimed to assess knowledge related to a patient-dependant phase of AMI and its determinants in adults. Questionnaire survey was conducted among a random sample of 942 men (48%) and women (52%) aged 63.50 ± 6.50 ...
Yoshioka Toru - - 2010
CD40 ligand (CD40L) plays a crucial role in atherogenesis and plaque destabilization. The purpose of this study was to clarify the association of CD40L levels in the culprit coronary arteries (CA) with the subsequent cardiovascular events in patients with acute myocardial infarction (AMI). We enrolled 68 patients with AMI whose ...
Berton Giuseppe - - 2010
C-reactive protein (CRP) is an established prognostic marker in the setting of acute coronary syndromes. Recently, albumin excretion rate also has been found to be associated with adverse outcomes in this clinical setting. Our aim was to compare the prognostic power of CRP and albumin excretion rate for long-term mortality ...
Fornengo C - - 2010
The aim of this study was to describe the five-year prognosis of an Italian cohort of patients following acute myocardial infarction (AMI) occurred at age ≤45 years and to investigate the potential role of risk predictors for future cardiovascular events (CVE). The study enrolled 112 consecutive patients aged ≤45 years ...
Parodi Guido - - 2010
This study sought to assess the relationship between 1-year mortality and baseline patient risk in the HORIZONS-AMI (Harmonizing Outcomes with RevasculariZatiON and Stents in Acute Myocardial Infarction) trial. The HORIZONS-AMI trial showed that bivalirudin compared with unfractionated heparin (UFH) plus glycoprotein IIb/IIIa inhibitors (GPI) decreased major bleeding and 30-day and ...
Sedlak Tara L - - 2010
Studies before the turn of the century reported sex differences in procedure rates. It is unknown whether these differences persist. To examine time trends and sex differences in coronary catheterization and revascularization following acute myocardial infarction (AMI). A retrospective analysis was performed of all patients 20 years of age or ...
Yang Shi-Wei - - 2010
OBJECTIVE: To assess the association between fasting plasma glucose (FPG) levels on admission and mortality in older patients with acute myocardial infarction (AMI), and compare the effects of FPG levels on outcomes in the context of contemporary treatments, including drug treatment, percutaneous coronary intervention and coronary artery bypass grafting. METHODS: ...
Mehri Sounira - - 2011
The objective of the study was to explore the role of a genetic variant of angiotensinogen (AGT), M235T, as an independent risk factor for acute myocardial infarction (AMI) and to investigate the possible association with the severity of coronary artery disease (CAD), estimated on the basis of the number of ...
Agarwal Udit - - 2010
Stromal cell-derived factor (SDF)-1/CXCR4 axis has an instrumental role during cardiac development and has been shown to be a potential therapeutic target for optimizing ventricular remodeling after acute myocardial infarction (AMI) and in ischemic cardiomyopathy. Although a therapeutic target, the specific role of cardiac myocyte CXCR4 (CM-CXCR4) expression following cardiogenesis ...
Lin Xiang-Min - - 2010
Postconditioning has been shown to reduce infarct size, ischemic/reperfusion injury and myocardial injury in patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI). This study tested the hypothesis that postconditioning attenuates the elevation of tumor necrosis factor-alpha (TNF-alpha) and improves heart function in patients with AMI after PCI. ...
Honda Tsuyoshi - - 2010
Increased resting heart rate (HR) due to sympathetic hyperactivity is associated with coronary risk factors and increased cardiovascular events. Acute myocardial infarction (AMI) is accompanied by autonomic imbalance, which is characterized by sympathetic activation and parasympathetic inactivation. Although an increased HR in patients with acute coronary syndrome has been reported ...
Liew Reginald - - 2010
Many patients who survive an acute myocardial infarction (AMI) remain at risk of sudden cardiac death despite optimal medical treatment. AMI survivors are currently risk assessed and selected for implantable cardioverter defibrillator (ICD) insertion mainly on the basis of their left ventricular ejection fraction. Several other cardiovascular tests are available ...
Goto Kosuke - - 2010
In patients with acute myocardial infarction (AMI), both myocardial blush grade (MBG) and coronary flow pattern obtained by transthoracic Doppler echocardiography (TTDE) have limitations in assessing myocardial viability. Accordingly, we assessed the usefulness of combination of MBG and TTDE in predicting myocardial damage following AMI. A total of 45 patients ...
Abuzeid Wael - - 2011
A case of acute myocardial infarction (AMI) in a patient with anorexia nervosa is presented. Clinlcal records, electrocardiogram, echocardiogram and coronary angiogram data of a patient with anorexia nervosa, presenting with AMI were evaluated. A Pubmed literature search was used to review cardiac complications of anorexia nervosa. The patient presented ...
Ibfelt Else - - 2010
To study welding fume particles in relation to cardiovascular diseases. In 1986, 10,059 male metal workers in 75 welding companies were sent a questionnaire about their welding experience and lifestyle (83.3% response rate). Of these, 5866 were available for analysis and had ever welded at baseline. Information on exposure to ...
Maruhashi Tatsuya - - 2010
Prodromal angina pectoris (AP) has a cardioprotective effect by the mechanism of ischemic preconditioning, and the QRS score on the admission electrocardiogram (ECG) reflects myocardial damage at presentation. This study was undertaken to investigate the effect of prodromal AP on infarct progression after the onset of acute myocardial infarction (AMI). ...
Candido Elisa - - 2011
To examine the relationship between selective nonresponse to a psychosocial questionnaire and mortality after acute myocardial infarction (AMI). Two thousand six hundred and ninety AMI survivors after AMI hospitalization were recruited to complete a 30-day follow-up interview. Patients were classified into four groups (survey nonparticipation and complete, partial, and no ...
Semb A G - - 2010
OBJECTIVES: To examine the rates of acute myocardial infarction (AMI) and ischaemic stroke (IS) and to examine the predictive value of total cholesterol (TC) and triglycerides (TG) for AMI and IS in patients with rheumatoid arthritis (RA) and people without RA. METHODS: In the Apolipoprotein MOrtality RISk (AMORIS) Study 480 ...
Sim Doo Sun - - 2010
The Korea Acute Myocardial Infarction Registry (KAMIR) was the first nationwide, population-based, multicenter data collection registry in Korea designed to track outcomes of patients presenting with acute myocardial infarction (AMI). The registry included 51 community and teaching hospitals and contained data on 14,870 patients through January 2008. Patients with non-ST-elevation ...
Twerenbold Raphael - - 2010
Acute myocardial infarction (AMI) is the major cause of death worldwide. Cardiac troponins (cTns) are structural proteins, unique to the heart, that currently form the cornerstone of the AMI diagnosis. The major limitation of standard cTn assays is a sensitivity deficit at presentation caused by a delayed increase of circulating ...
Bian Yuan - - 2010
Aldehyde dehydrogenase-2 (ALDH2) is a key enzyme of alcohol metabolism, catalyzing the conversion of aldehyde to acetic acid. The G-to-A polymorphism in exon 12 of the ALDH2 gene, which causes Glu-to-Lys substitution at codon 504, has been shown to be an independent risk factor for acute myocardial infarction (AMI). We ...
Marra Martina Perazzolo - - 2010
BACKGROUND: Although angiographic perfusion has been traditionally evaluated by myocardial blush grade (MBG), pathophysiologic features underlying different MBG and the persistent blush, traditionally called staining, have been poorly explained. The aim of the study was to evaluate the correlation between MBG and morphologic aspects on cardiac magnetic resonance (CMR). METHODS: ...
Ozawa Takuya - - 2010
Erythropoietin (EPO) has been found to have anti-apoptotic and tissue protective effects on the myocardium. The aim of the present pilot study was to observe the safety and efficacy of EPO administration for patients with acute myocardial infarction (AMI). Patients admitted with AMI had all undergone successful percutaneous coronary intervention ...
Steinvil Arie - - 2010
Previous studies have demonstrated the presence of increased erythrocyte aggregation (EA) in patients with acute coronary syndromes (ACS). We have presently explored the correlation between the time from symptom onset to the appearance of an inflammatory response and aggregated erythrocytes in the peripheral blood of ACS patients. Consecutive individuals undergoing ...
Nozawa Naoki - - 2010
Monocytes and macrophages have been shown to play major roles in the progression of atherosclerosis. This study examined whether the circulating monocyte count can be used to predict coronary plaque progression of non-culprit intermediate lesions in acute myocardial infarction (AMI). Intravascular ultrasound findings of non-culprit intermediate plaque in 90 patients ...
Heitner John F - - 2010
Inflammation has been shown to be a major component in the pathophysiology of acute coronary syndrome (ACS). In patients presenting with acute myocardial infarction (AMI), a critical component of the ACS spectrum, multiple coronary arteries are involved during this inflammatory process. In addition to the coronary vasculature, the inflammatory cascade ...
Rocha Antônio Sérgio Cordeiro da - - 2010
The monitoring of healthcare quality indicators (HCQI) is a process of utmost importance in patient healthcare services. To evaluate whether the monitoring of HCQI and the root-cause analysis improve the healthcare quality in acute myocardial infarction (AMI). A cross-sectional and comparative analysis of HCQI was performed in patients with AMI ...
Chen Jiann-Hwa - - 2010
OBJECTIVE: The aims of this study are to analyze the factors that predispose the occurrence of ventricular arrhythmia (VA) in young patients with a first acute myocardial infarction (AMI) in the emergency department (ED) and to establish predictive implications. METHODS: This is a 10-year retrospective cohort study. Patients who were ...
Prech Marek - - 2010
Apoptosis is recognized as a mechanism of cell loss in the setting of acute myocardial infarction (AMI). Whether it contributes to myocyte elimination late after AMI has not yet been confirmed. We attempted to identify the features of apoptosis in myocytes that survived AMI. A search for ongoing apoptosis was ...
Cheng Yunhui - - 2010
miRNAs (microRNAs) participate in many diseases including cardiovascular disease. In contrast with our original hypothesis, miRNAs exist in circulating blood and are relatively stable due to binding with other materials. The aim of the present translational study is to establish a method of determining the absolute amount of an miRNA ...
Erden Ismail - - 2010
Data related to the incidence and clinical outcome of acute myocardial infarction (AMI) in patients with preexisting coronary artery ectasia (CAE) are limited. We assessed whether infarct-related artery ectasia (EIRA) indicates an untoward clinical outcome in patients with AMI undergoing primary percutaneous coronary intervention (pPCI). Consecutive patients (n = 643) ...
Xia Shuang - - 2010
AIMS: To investigate dynamic changes in the expression of HCN2, HCN4, as well as KCNE1, and KCNE2 mRNA and protein levels in ventricular cells from acute myocardial infarction (AMI) rat hearts. MAIN METHODS: An AMI model was induced by ligating the left anterior descending coronary artery (LAD) of Sprague-Dawley rats. ...
Begieneman Mark P V - - 2010
In the present study, ultrastructural analysis of mitochondrial deposits (black dots within mitochondria) as a method for the detection of early acute myocardial infarction (AMI) was evaluated. In 24 patients with AMI and six controls, analysis was performed in the heart of infarcted patients and noninfarcted controls. In the infarction ...
Fesmire Francis M - - 2010
OBJECTIVE: No information is currently available regarding the optimal cutoff values of the baseline ST-segment deviation sum (STDsum(baseline)) and 60-minute ST-segment deviation change (STDchange(60 min)) for predicting acute myocardial infarction (AMI). METHODS: A retrospective study was performed in 783 admitted patients with chest pain who had suspected acute coronary syndrome ...
Abbate Antonio - - 2010
Acute myocardial infarction (AMI) initiates an intense inflammatory response in which interleukin-1 (IL-1) plays a central role. The IL-1 receptor antagonist is a naturally occurring antagonist, and anakinra is the recombinant form used to treat inflammatory diseases. The aim of the present pilot study was to test the safety and ...
Van Belle Eric - - 2010
BACKGROUND: Little is known about the capacity of ischemia-modified albumin (IMA) plasma concentration to predict long-term cardiac outcome in patients with established acute myocardial infarction (AMI). Because IMA is a marker of ischemia rather than myocardial cell damage, we hypothesized that IMA plasma levels could provide additional prognostic value to ...
Schopfer David - - 2010
The American College of Cardiology/American Heart Association guidelines for acute myocardial infarction related to process of care aim to decrease morbidity and mortality and provide a standard of care for patients with acute myocardial infarction (AMI). Currently, there are limited data comparing adherence between centers providing fibrinolytic therapy alone and ...
Wi Jin - - 2010
Coronary artery aneurysms are uncommon, are usually associated with atherosclerosis, and rarely involve all three major coronary arteries. The present report describes a rare case of a young female patient presenting with acute myocardial infarction (AMI). Coronary angiography revealed multiple severe aneurysmal and stenotic changes. Based on clinical feature and ...
Arruda-Olson Adelaide M - - 2010
To examine left ventricular (LV) function in patients after acute myocardial infarction (AMI) and assess its relation to C-reactive protein (CRP) as a measure of the early inflammatory response. We measured the CRP levels early after AMI and correlated them with the early structural and functional cardiac alterations. From November ...
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