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IJkema B B L M BB Department of Cardiology, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, the - - 2014
The major initial triaging decision in acute coronary syndrome (ACS) is whether or not percutaneous coronary intervention (PCI) is the primary treatment. Current guidelines recommend primary PCI in ST-elevation ACS (STEACS) and initial antithrombotic therapy in non-ST-elevation ACS (NSTEACS). This review probes the question whether this decision can indeed be ...
Zeymer Uwe U Klinikum Ludwigshafen, Medizinische Klinik B, Ludwigshafen, - - 2014
Aims: Current guidelines recommend immediate multivessel percutaneous coronary intervention (PCI) in patients with cardiogenic shock, despite the lack of randomised trials. We sought to investigate the use and impact on outcome of multivessel PCI in current practice in cardiogenic shock in Germany. Methods and results: Between January 2008 and December ...
Marfil-Álvarez R R Department of Periodontics, School of Dentistry, University of Granada, - - 2014
Cardiovascular disease has been associated with 40% of deaths in high-income countries and 28% in lower-income countries. The relationship between periodontitis and acute myocardial infarction is well documented, but it has not been established whether the extent and severity of periodontitis influence the infarct size. This cross-sectional and analytic study ...
Dobric Milan M Department of Cardiology, Clinical Center of Serbia, Belgrade, Serbia; School of Medicine, University of Belgrade, Belgrade, Serbia. Electronic address: - - 2014
Early experimental and clinical reports on glycogen phosphorylase BB (GPBB) kinetics following myocardial ischemic injury suggested that it could be a useful diagnostic marker for early detection of acute myocardial infarction (AMI). After more than two decades of investigation, there is now overwhelming body of evidence that do not support ...
Martí Vicens V Hospital Santa Creu y San Pau, Barcelona, Spain. Electronic address: - - 2014
Antiphospholipid syndrome (APS) is an autoimmune coagulation disorder that manifests clinically as venous and arterial thrombosis, and may affect any tissue or organ. Coronary artery involvement, however, is very rare. Case reports in the literature describing patients with coronary acute syndrome and APS treated with coronary angioplasty show conflicting results. ...
Krishnamoorthy Arun A aDivision of Cardiology, Department of Medicine bDuke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, - - 2014
Fluid removal and relief of congestion are central to treatment of acute heart failure. Diuretics have been the decongestive mainstay but their known limitations have led to the exploration of alternative strategies. This review compares diuretics with ultrafiltration and examines the recent evidence evaluating their use. Relevant recent studies are ...
van Son Brechtje B Neurology Department, University Hospitals Leuven, Leuven, Belgium. Electronic address: - - 2014
A 55-year-old woman was admitted with a 3 days history of increasing lethargy with bradyphrenia and apathy. She progressively developed severe somnolence with marked abulia, right hemiparesis, right hemianopsia, and pseudobulbar palsy. Brain magnetic resonance imaging showed the rare image of bilateral acute anterior choroidal artery infarction. Pseudobulbar mutism and in ...
Dayawansa Nalin H - - 2014
First discovered in 1966 as an inflammatory cytokine, MIF (macrophage migration inhibitory factor) has been extensively studied for its pivotal role in a variety of inflammatory diseases, including rheumatoid arthritis and atherosclerosis. Although initial studies over a decade ago reported increases in circulating MIF levels following acute MI (myocardial infarction), ...
Piepoli Massimo M Heart Failure Unit, Cardiology Department, Guglielmo da Saliceto Hospital, Piacenza, - - 2014
Acute decompensated heart failure (ADHF) is the most common cause of cardiovascular hospitalization. The presentation is characterized by different clinical profiles due to various underlying causes, volume balance and tissue perfusion status. Currently, a variety of pharmacological therapies, including diuretics, beta-blockers, ACE-inhibitors, angiotensin receptor blockers and digoxin, are usually prescribed ...
Kubo Takashi T Department of Cardiovascular Medicine, Wakayama Medical - - 2014
Optical coherence tomography (OCT) is a catheter-based imaging system that uses near-infrared light to produce cross-sectional images of the coronary arteries. With its extraordinarily high resolution (10-20 μm), OCT allows clinicians to observe various morphological features of coronary atherosclerosis in vivo. For example, intimal thickening presents as homogeneous, signal-rich regions ...
Tarvasmäki Tuukka T Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland. Electronic address: - - 2014
Acute coronary syndromes (ACS) may precipitate up to a third of acute heart failure (AHF) cases. We assessed the characteristics, initial management, and survival of AHF patients with (ACS-AHF) and with no concomitant ACS (nACS-AHF). Data from 620 AHF patients were analyzed in a prospective multicenter study. The ACS-AHF patients ...
Marti Vicens V Servicio de Cardiología, Hospital de Sant Pau, Barcelona, - - 2014
Invasive and pharmacological treatment of ST-segment elevation acute myocardial infarction reduces the rate of ischemic events but not bleeding complications. The objective of this study was to compare clinical results and bleeding complications between femoral and radial access routes in patients with ST-segment elevation acute myocardial infarction. An evaluation was ...
Wollenweber Tim T Department of Cardiology and Angiology, Hannover Medical School, - - 2014
-Myocardial infarction (MI) triggers a systemic inflammatory response which determines subsequent healing. Experimentally, cardiac positron (PET) and magnetic resonance(CMR) imaging has been used successfully to obtain mechanistic insights. We explored the translational potential in patients early after MI. -PET/CT and CMR were performed in 15 patients <7 days after first ...
Meimoun Patrick P Cardiology Department and Intensive Care Unit, Compiegne's Hospital, Centre Hospitalier de Compiègne, 8 rue Henri Adnot, 60200, Compiègne, France, - - 2014
After acute-anterior myocardial infarction (AMI), left ventricular (LV) viable myocardial segments show some degree of active deformation (longitudinal shortening) despite wall motion abnormalities (WMA). Tako-tsubo cardiomyopathy (TTC) is characterized by myocardial stunning; however, it is unclear whether in TTC the strain pattern mimics AMI. To compare the strain-pattern in TTC ...
Morimont Philippe P GIGA - Cardiovascular Sciences, Hemodynamics, University of Liège, Belgium; Medical Intensive Care Unit, University Hospital of Liège, Belgium. Electronic address: - - 2014
The time constant of left ventricular (LV) relaxation derived from a monoexponential model is widely used as an index of LV relaxation rate, although this model does not reflect the non-uniformity of ventricular relaxation. This study investigates whether the relaxation curve can be better fitted with a "quadratic" model than ...
Guarini Giacinta G Cardiovascular Medicine Division, Cardio-Thoracic and Vascular Department, University of Pisa, - - 2014
In recent decades coronary microvascular dysfunction has been increasingly identified as a relevant contributor to several cardiovascular conditions. Indeed, coronary microvascular abnormalities have been recognized in patients suffering acute myocardial infarction, chronic stable angina and cardiomyopathies, and also in patients with hypertension, obesity and diabetes. In this review, we will ...
Kawai Hideki H Departments of Cardiology, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan, - - 2014
Two patients after Kawasaki disease (KD) developed acute myocardial infarction in their thirties, though coronary artery follow-up were deemed unnecessary because of apparently angiographic normal coronary arteries in their children more than 1-year after acute KD. Angiographic findings of apparently normal coronary arteries in the late period after acute KD ...
Cauley Keith A KA 1 Department of Radiology, Division of Neuroradiology, Columbia Presbyterian Medical Center, 630 W 168th St, New York, NY - - 2014
OBJECTIVE. Hydrocephalus causes changes in the diffusion-tensor properties of periventricular white matter. Understanding the nature of these changes may aid in the diagnosis and treatment planning of this relatively common neurologic condition. Because ventricular size is a common measure of the severity of hydrocephalus, we hypothesized that a quantitative correlation ...
Möckel Martin M Department of Cardiology and Division of Emergency Medicine, Campus Viorchow Klinikum (CVK) and Campus Charité Mitte (CCM), Charité - Universitätsmedizin Berlin, Charitéplatz 1, Berlin, 10117, Germany, - - 2014
The concentration of copeptin, the C-terminal part of pro-arginine vasopressin, has been shown to increase early after acute and severe events. Owing to complementary pathophysiology and kinetics, the unspecific marker copeptin, in combination with highly cardio-specific troponin, has been evaluated as an early-rule-out strategy for acute myocardial infarction in patients ...
Ibrahim Akram W AW Division of Cardiology, Department of Medicine, Emory University School of Medicine, Emory University Hospital Midtown, Medical Office Tower, 550 Peachtree Street, Atlanta, GA 30308, - - 2014
This article discusses the approach to the management of myocardial infarction (MI) in the intensive care unit setting. It includes an overview of the definition, classification, and underlying pathologic conditions of acute MI and specifically discusses the diagnosis and management of unstable angina, non-ST elevation MI, and ST-segment elevation MI. ...
Teuteberg Jeffrey J JJ Heart and Vascular Institute, University of Pittsburgh Medical Center, Scaife Hall, Suite 556, 200 Lothrop Street, Pittsburgh, PA 15213, USA. Electronic address: - - 2014
Cardiogenic shock remains a leading cause of mortality despite advances in the treatment of myocardial infarction and advanced heart failure. Medical therapy can be inadequate, and patients may need mechanical circulatory support (MCS). The proper application of MCS requires knowledge of the underlying cause of acute heart failure, familiarity with ...
Mohindra Rohit - - 2014
Clinical questionIn emergency department patients with symptoms suggestive of acute myocardial infarction, is the absolute or relative change of cardiac troponin assays (either high sensitivity or ultrasenstive) more accurate in diagnosing acute myocardial infarction at 1 to 2 hours postpresentation?Article chosenRechlin T, Ifran A, Twerenbold R, et al. Utility of ...
Bilgin Murat M Department of Cardiology, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey. - - 2014
Kounis syndrome (KS) is characterized by concurrent acute coronary syndrome and allergic reaction, in which acute inflammatory mediators cause spasm and/or erosion and rupture of coronary atheromatous plaque. In this report, we remind clinicians to consider KS in patients who are subjected to allergenic substances and demonstrate acute chest pain. ...
Ludka Ondrej O Department of Internal Medicine and Cardiology, University Hospital Brno, Czech Republic; International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic; Faculty of Medicine, Masaryk University, Brno, Czech - - 2014
While sleep apnea (SA) might be a modifiable cardiovascular risk factor, recent data suggest that SA is severely underdiagnosed in patients after acute myocardial infarction (MI). There is limited evidence about day-night variation of onset of MI on dependence of having SA. We therefore investigated the prevalence of SA and ...
Asvestas Dimitrios D Dimitrios Asvestas, Konstantinos Vlachos, Anastasios Salachas, Konstantinos P Letsas, Antonios Sideris, Second Department of Cardiology, Evangelismos General Hospital, 10676 Athens, - - 2014
Acute myocardial infarction should be diagnosed as early as possible for the appropriate management to salvage ischemic myocardium. Accurate diagnosis is typically based on the typical symptoms of angina. Headache is an unusual symptom in patients with acute myocardial infraction. We report a patient with ST-segment elevation acute myocardial infarction ...
Boyde Mary M Princess Alexandra Hospital, Cardiology Department, Brisbane, Queensland, Australia; The University of Queensland, School of Nursing and Midwifery, Brisbane, Queensland, Australia. Electronic address: - - 2014
Education for hospitalised patients is an important aspect of care for people who have an acute cardiovascular event. To investigate the cardiovascular risk factor behaviours of patients together with their acute coronary syndrome (ACS) knowledge, attitudes and beliefs following admission to hospital for an acute myocardial infarction. Patients diagnosed with ...
Tang Bei B Department of Critical Care Medicine, The First People's Hospital of Jiande City, 599 Yanzhou Main Road, Jiande 311600, - - 2014
Intermedin functions systemically as a potent vasodilator and its plasma levels have been shown to be elevated in patients with acute myocardial infarction. This study aimed to evaluate the prognostic value of plasma intermedin level in the patients with ST-segment elevation acute myocardial infarction. Plasma intermedin concentrations of 128 patients ...
Gempp E E Service de médecine hyperbare et expertise plongée, hôpital d'instruction des Armées Sainte-Anne, BP 600, 83800 Toulon cedex 9, France. Electronic address: - - 2014
Inner ear decompression sickness following scuba diving is not uncommon and the characteristic features of this disorder are acute peripheral vestibular syndrome, sometimes associated with cochlear signs, requiring urgent hyperbaric oxygen therapy. Cerebellar infarction can also mimic isolated peripheral vestibulopathy. The authors report the case of a 47-year-old man in ...
McNamara Michael W MW aSH Meijer Heart Center, Grand Rapids bDepartment of Cardiovascular Medicine, William Beaumont Hospital, Beaumont Health System, Royal Oak cOakland University William Beaumont Hospital School of Medicine, Rochester, Michigan, - - 2014
This study investigated the immediate hemodynamic effects of intra-aortic balloon pump (IABP) support and clinical outcomes in patients with acute right ventricular infarction (RVI) complicated by hypotension. IABP improves hypotension in patients with acute myocardial infarction and left ventricular shock, but the effects have not been well studied in acute ...
Parkkonen Olavi O HUCH Heart and Lung Center, Helsinki University Central Hospital (HUCH), Helsinki, Finland. Electronic address: - - 2014
Previous efforts to distinguish acute anterior ST-elevation myocardial infarction (anterior-STEMI) from various forms of takotsubo cardiomyopathy (TTC) by electrocardiography (ECG) have produced differing results. We performed a retrospective comparison of acute ECGs between 48 apical and 9 mid-ventricular TTC patients, with 96 anterior-STEMI patients. ECG was recorded in acute phase ...
Vermes Emmanuelle E Stephenson Cardiovascular MR Centre, Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada Service de Chirurgie Cardiaque et Radiologie, Hôpital Trousseau-CHRU de Tours, Avenue de la République, Chambray-lès-Tours 37170, - - 2014
We assessed the value of cardiovascular magnetic resonance (CMR) criteria ('Lake Louise Criteria') for predicting left ventricular (LV) functional improvement in patients with acute myocarditis. We studied 37 patients who referred for acute myocarditis during clinically acute myocarditis and after a 12-month follow-up. CMR sequences sensitive for oedema, hyperaemia, and ...
Soukoulis Victor V From the Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (V.S., P.T.O.); Division of Cardiology, Department of Medicine, Albany Stratton Veteran's Affairs Medical Centre and Albany Medical College, NY (W.E.B.); and Division of Cardiology, University of North Carolina, Chapel Hill - - 2014
Acute coronary syndromes (ACS) constitute a spectrum of clinical presentations ranging from unstable angina and non-ST-segment elevation myocardial infarction to ST-segment myocardial infarction. Myocardial ischemia in this context occurs as a result of an abrupt decrease in coronary blood flow and resultant imbalance in the myocardial oxygen supply-demand relationship. Coronary ...
Mackiewicz Urszula U Department of Clinical Physiology, Medical Center of Postgraduate Education, Warsaw, - - 2014
Ventricular arrhythmias are an important cause of mortality in the acute myocardial infarction (MI). To elucidate effect of ivabradine, pure heart rate (HR) reducing drug, on ventricular arrhythmias within 24 h after non-reperfused MI in the rat. ECG was recorded for 24 h after MI in untreated and ivabradine treated rats and ...
Levy Phillip D PD Associate Professor of Emergency Medicine, Assistant Director of Clinical Research, Cardiovascular Research Institute, Associate Director of Clinical Research, Department of Emergency, Medicine, Wayne State University School of Medicine, 4201 St. Antoine; UHC - 6G, Detroit, MI - - 2014
Vasodilators play an important role in the management of acute heart failure, particularly when increased afterload is the precipitating cause of decompensation. The time-honored approach to afterload reduction has been largely focused on use of intravenous nitrovasodilators and, when properly dosed, this class of agents does provide substantial symptom relief ...
Franco Joseph John JJ Department of Cardiology, Temple University Hospital, Philadelphia, Pennsylvania - - 2014
A 42-year-old man emergently presented with chest pain and anterior ST elevation. Refractory ventricular arrhythmias and shock developed rapidly. A coronary angiogram revealed the acute occlusion of a nondominant right coronary artery. After percutaneous coronary intervention, the anterior ST elevation and ventricular arrhythmias resolved. The electrocardiographic pattern was a result ...
Aseri Zohair Al ZA Department of Emergency Medicine, King Khalid University Hospital, King Saud University, Riyadh, Saudi - - 2014
Objective: To determine high sensitivity C-reactive protein (hsCRP) levels in patients with acute myocardial infarction (AMI) and its correlation with classical enzyme markers of myocardial damage. Study Design: Observational study. Place and Duration of Study: Department of Emergency Medicine at King Khalid University Hospital, King Saud University, Riyadh and Department ...
Redington Andrew N AN Division of Cardiology, Hospital for Sick Children, and Department of Paediatrics, University of Toronto, Toronto, Ontario, - - 2014
The importance of right ventricular dysfunction, as a driver of symptoms and outcomes in the normal biventricular circulation, is increasingly recognized. However, the pathophysiologic mechanisms underlying the role of the right ventricle in acute and chronic hemodynamic deterioration are less well understood. This review aims to clarify the impact of ...
Redfors Björn B Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Sahlgrenska Academy at University of Gothenburg, Bruna Stråket 16, 413 45 Gothenburg, Sweden ; Department of Cardiology, Sahlgrenska University Hospital, Bruna Stråket 16, 413 45 Gothenburg, - - 2014
Takotsubo cardiomyopathy (TCM) is an acute cardiac syndrome characterized by extensive, but potentially reversible, left ventricular dysfunction in the absence of an explanatory coronary obstruction. Thus, TCM is distinct from coronary artery disease (CAD) and acute myocardial infarction (AMI). However, substantial evidence for co-existing CAD in some TCM patients exist. ...
Dharma Surya S Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, - - 2014
The objective of this study is to determine the efficacy and safety of an everolimus-eluting stent (EES/Xience; Abbott Vascular, Santa Clara, CA) compared with a cobalt chromium stent (CoCr/Multi-Link Vision; Abbott Vascular) in patients with acute ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) with routine administration of ...
Howard James P JP Barts NIHR Cardiovascular Biomedical Research Unit, William Harvey Research Institute, Barts and The London Medical School, Queen Mary University, London, - - 2014
Anti-thrombotic drugs constitute the cornerstone of therapy in the management of acute coronary syndromes (ACS) and for patients undergoing percutaneous coronary intervention. Anti-thrombotic therapy during percutaneous coronary intervention for ACS has evolved substantially over the past 15 years. In the original 1996 ACC/AHA guidelines for the management of acute myocardial ...
Savonitto Stefano S Divisione di Cardiologia, Ospedale Manzoni, Lecco, Italy. Electronic address: - - 2014
Acute coronary syndromes have a wide spectrum of clinical presentations and risk of adverse outcomes. A distinction should be made between treatable (extent of ischemia, severity of coronary disease and acute hemodynamic deterioration) and untreatable risk (advanced age, prior myocardial damage, chronic kidney dysfunction, other comorbidities). Most of the patients ...
Niu Xiaowei X The First Clinical Medical School, Lanzhou University, Lanzhou, Gansu, - - 2014
Our aim was to evaluate the incremental predictive value of adding mean platelet volume (MPV) to the Global Registry of Acute Coronary Events (GRACE) risk score. The MPV and GRACE score were determined on admission in 509 consecutive patients with acute coronary syndrome (ACS). Six-month mortality or nonfatal myocardial infarction ...
Bresee Lauren C LC Department of Medicine (Bresee, Knudtson, Zhang, Ahmed, Ghali, Manns, Fabreau, Hemmelgarn), Libin Cardiovascular Institute of Alberta (Knudtson, Ahmed, Ghali, Quan, Manns, Hemmelgarn), Institute for Public Health (Crowshoe, Ghali, Quan, Manns, Hemmelgarn) and Department of Family Medicine (Crowshoe), University of Calgary, Calgary, Alta.; Department of Medicine (Tonelli), University of Alberta, Edmonton, Alta.; Department of Community Health Sciences (Ghali, Quan, Manns, Hemmelgarn), University of Calgary, Calgary, Alta.; Brigham and Women's Hospital (Fabreau) and Department of Health Care Policy (Fabreau), Harvard Medical School, Boston, - - 2014
Morbidity due to cardiovascular disease is high among First Nations people. The extent to which this may be related to the likelihood of coronary angiography is unclear. We examined the likelihood of coronary angiography after acute myocardial infarction (MI) among First Nations and non-First Nations patients. Our study included adults ...
Rumana Nahid N Department of Health Science, Shiga University of Medical Science, Shiga, Japan; Sleep Center, Foothills Medical Center, Calgary, Alberta, - - 2014
Few comprehensive stroke and acute myocardial infarction registries of long duration exist in Japan to illustrate trends in acute case-fatality of stroke and acute myocardial infarction with greater precision. We examined 17-year case-fatality rates of stroke and acute myocardial infarction using an entire community-monitoring registration system to investigate trends in ...
Planer David D From the Hadassah-Hebrew University Medical Center, Jerusalem, Israel (D.P.); Icahn School of Medicine at Mount Sinai, New York, NY (R.M.); Cardiovascular Research Foundation, New York, NY (R.M., K.X., G.W.S.); Duke University Medical Center, Durham, NC (E.M.O.); Green Lane Cardiovascular Service, Auckland City Hospital, Auckland, New Zealand (H.D.W.); and Columbia University Medical Center, New York, NY (J.D.N., - - 2014
Troponin elevation is a risk factor for mortality in patients with non-ST-segment-elevation acute coronary syndromes. However, the prognosis of patients with troponin elevation and nonobstructive coronary artery disease (CAD) is unknown. Our objective was therefore to evaluate the impact of nonobstructive CAD in patients with non-ST-segment-elevation acute coronary syndromes and ...
Aslan S S Cerrahpasa Medical Faculty, Department of Cardiology, Istanbul University, Istanbul, - - 2014
Vitronectin (VN) functions as a regulator of platelet adhesion and aggregation, coagulation, and fibrinolysis. The aim of this study was to assess the prognostic significance of serum VN levels in patients with acute myocardial infarction (MI). In this study 62 patients admitted with ST-elevation myocardial infarction (STEMI), or non-ST-elevation myocardial ...
Ferrara Francesco F Heart Department, University Hospital 'Scuola Medica Salernitana', Salerno, Italy Department of Translational Medical Sciences, 'Federico II' University, Naples, - - 2014
Takotsubo cardiomyopathy is an acute reversible clinical condition mimicking an acute myocardial infarction. Although a normal coronary artery tree is frequently detected, the concurrence of coronary artery disease is a common finding in a substantial proportion of patients. We report an unusual case of takotsubo cardiomyopathy in post-menopausal women after ...
Fujino Masayuki M Department of Pediatrics, Fujita Health University, Toyoake, Japan, - - 2014
Kawasaki disease complicates with myocarditis and vasculitis. Even if myocarditis is asymptomatic, heterogeneity of ventricular repolarization may be increased in the acute phase. We evaluated whether the change in repolarization characteristics can be used as a predictor for myocarditis and coronary lesions. Enrolled 34 children who were treated with intravenous ...
Sluijter Joost P G JP Nucleus of the European Society of Cardiology Working Group Cellular Biology of the - - 2014
The morbidity and mortality from ischemic heart disease (IHD) remain significant worldwide. The treatment for acute myocardial infarction has improved over the past decades, including early reperfusion of occluded coronary arteries. Although it is essential to re-open the artery as soon as possible, paradoxically this leads to additional myocardial injury, ...
Ota Shingo S Department of Cardiovascular Medicine, Wakayama Medical - - 2014
T2 weighted (T2W) images on cardiovascular magnetic resonance (CMR) visualizes myocardial edema, which reflects the myocardial area at risk (AAR) in reperfused acute myocardial infarction (AMI). Late gadolinium enhancement (LGE) demonstrates myocardial infarction. LGE images cover the whole left ventricle, but T2W images are obtained from a few slices of ...
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