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Betgem Ryanne P RP Department of Cardiology, Institute for Cardiovascular Research, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, - - 2014
In patients with acute myocardial infarction (AMI), the guideline-recommended treatment is mechanical revascularization by percutaneous coronary intervention (PCI), which is effective at reducing mortality. However, a substantial proportion of patients with AMI develop chronic cardiac failure owing to poor restoration of microvascular function and myocardial perfusion, despite restoration of epicardial ...
Drabek Tomas T University of Pittsburgh School of Medicine, Pittsburgh, PA - - 2014
Until the early 1950's there did not exist any effective treatment for airway obstruction or cardiac arrest for laypersons. In the late 50's isolated steps were described to establish a patent airway (A), provide mouth-to-mouth breathing (B) and restore circulation (C) with chest compressions. Tying those steps together into an ...
Sanchez Aura A AA Department of Pediatrics, Washington University School of Medicine, One Children's Place, Campus Box 8116-NWT, St. Louis, MO, 63110, - - 2014
Obesity is an independent predictor of heart failure in adults. Obese individuals have increased hemodynamic load and neuro-hormonal activation that contribute, but cannot entirely explain the reported changes in ventricular structure and function leading to heart failure. There are intrinsic alterations in the myocardium that are independent of load. Insulin ...
Kumar Saurabh S Cardiac Arrhythmia Service, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, - - 2014
Ventricular arrhythmias (VA) are a significant contributor to morbidity and mortality in patients with heart failure (HF). Implantable cardioverter defibrillators are effective in reducing mortality, but do not prevent arrhythmia recurrence. There is increasing recognition that frequent premature ventricular contractions or repetitive ventricular tachycardia may also lead to new onset ...
Wolf Sarah S From the *Department of Emergency Medicine, Emory University, Atlanta GA; †Department of Internal Medicine, Wayne State University, Detroit, MI; ‡Department of Emergency Medicine, Metro Health Hospital-Statewide Campus System, Michigan State University College of Osteopathic Medicine, Wyoming, MI; §Oakwood Heritage Transitional Year Residency Program/Oakwood Healthcare, Taylor, MI; ¶Department of Internal Medicine, Loma Linda University, Loma Linda, CA; ‖Department of Emergency Medicine, St. John Hospital and Medical Center, Detroit, MI; **Department of Internal Medicine, California Pacific Medical Center, San Francisco, CA; ††Wayne State University School of Medicine, Detroit, MI; ‡‡Department of Emergency Medicine, Wayne State University School of Medicine, Detroit, MI; and §§Cardiovascular Research Institute, Wayne State University School of Medicine, Detroit, - - 2014
To evaluate the clinical impact of a troponin assay switch in suspected acute coronary syndromes (ACS). Retrospective analysis of ACS cases in the 3 months before and after changing to a contemporary, higher sensitivity troponin assay. Admitting diagnosis, proportion with a positive result, initial treatment and testing, coronary artery intervention, ...
Meuwese C L CL Department of Cardiology, Groene Hart Hospital, Bleulandweg 10, 2803 HH, Gouda, the Netherlands, - - 2014
In this image case we describe a relatively rare vascular malformation known of as Thebesian veins, which in some cases could cause cardiac ischemia and ventricular arrhytmias.
Wollenweber Tim T Department of Nuclear Medicine, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, - - 2014
Ventricular tachycardia (VT) is a major cause of sudden cardiac death (SCD) in patients with heart failure (HF). Left ventricular ejection fraction (LVEF) and heart failure class according to the New York Heart association (NYHA) are in most common use to identify patients that may benefit from implantable cardioverter defibrillator ...
Ahmad Firdos F Center for Translational Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania; Division of Cardiovascular Medicine, Vanderbilt University, Nashville, - - 2014
Injury due to myocardial infarction (MI) is largely irreversible. Once an infarct has occurred, the clinical goal becomes limiting remodeling, preserving left ventricular function, and preventing heart failure. Although traditional approaches (e.g., β-blockers) partially preserve left ventricular function, novel strategies are needed to limit ventricular remodeling post-MI. The aim of ...
Wu Zheng Z Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health and Key Laboratory of Molecular Cardiovascular Sciences, Department of Cardiology, Peking University Third Hospital, Ministry of Education , Beijing , - - 2014
Abstract Catestatin (CST) was first discovered as a potent non-competitive and reversible inhibitor of catecholamine secretion. Recent reports on plasma CST level in heart diseases suggested a cardioprotective role for this peptide. Given that cardiac remodeling is the dominant pathologic process in cardiac dysfunction, we propose that CST participates in ...
Hackenhaar Fernanda - - 2014
BackgroundReperfusion after resuscitation from cardiac arrest (CA) is an event that increases reactive oxygen species production leading to oxidative stress. More specifically, myocardial oxidative stress may play a role in the severity of post-CA myocardial dysfunction. This study investigated the relationship between myocardial oxidative stress and post-CA myocardial injury and ...
Mao Qing Q Department of Cardiology, The First People's Hospital of Changzhou, The Third Affiliated Hospital of Suzhou University, Changzhou, - - 2014
In the present study, we investigated whether mesenchymal stem cells (MSCs) overexpressing integrin-linked kinase (ILK) might regulate ventricular remodeling and cardiac function in a porcine myocardial infarction model. ILK-modified MSCs (ILK-MSCs) (n = 8), MSCs (n = 8) or placebo (n = 8) were injected into peri-infarct myocardium 7 days after ligation of the left anterior descending ...
Thenappan Thenappan T Cardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, - - 2014
Pulmonary hypertension (PH) leading to right ventricular failure (RVF) is a common complication of left heart failure irrespective of the left ventricular ejection fraction. PH due to left heart disease is the most common cause of PH. The prevalence of PH and RVF in left heart failure varies depending on ...
Tehrani P P School of Mechanical Engineering, Iran University of Science and Technology, Tehran 16846, Iran Tissue Engineering and Biological Systems Research Lab, School of Mechanical Engineering, Iran University of Science and Technology, Tehran 16887, Iran - - 2014
Heart failure is responsible for 30% of all mortalities worldwide. A cardiac assist device is typically suggested by surgeons to compensate for the failure of the heart. This study calculated the generated power by a specific type of cardiac assist device, namely, the AVICENA, which is implanted into an aorta ...
Dvir Hila H Department of Biomedical Engineering, Faculty of Engineering, Tel-Aviv University, Tel-Aviv, - - 2014
Low pacing variabilty in the heart has been clinically reported as a risk factor for lethal cardiac arrhythmias and arrhythmic death. In a previous simulation study, we demonstrated that stochastic pacing sustains an antiarrhythmic effect by moderating the slope of the action potential duration (APD) restitution curve, by reducing the ...
Barold S Serge SS Florida Heart Rhythm Institute, Tampa, - - 2014
The left ventricular (LV) channel of Biotronik biventricular devices used for cardiac resynchronization therapy (CRT) is designed with the capability of sensing via the LV lead. Therefore a displaced LV lead in a coronary vein could sense far-field atrial signals and interfere with CRT. The Biotronik troubleshooting archives containing data ...
Boczonadi Veronika V Institute of Genetic Medicine, Newcastle University, - - 2014
The organization and maturation of ventricular cardiomyocytes from the embryonic to the adult form is crucial for normal cardiac function. We have shown that a polarity protein, Scrib, may be involved in regulating the early stages of this process. Our goal was to establish whether Scrib plays a cell autonomous ...
Santavy Petr P Department of Cardiac Surgery, Palacky University Teaching Hospital, Olomouc, Czech Republic - - 2014
We report a case of a metal splinter ejected by a circular saw tooth from a wooden board into the left ventricle of the heart. A 35-year old man was admitted second day after accident attributed to work complaining about general weakness. Only a small non-bleeding wound was found near ...
Han Peidong P Institute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine and State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100871, - - 2014
While the adult human heart has very limited regenerative potential, the adult zebrafish heart can fully regenerate after 20% ventricular resection. Although previous reports suggest that developmental signaling pathways such as FGF and PDGF are reused in adult heart regeneration, the underlying intracellular mechanisms remain largely unknown. Here we show ...
Cristescu Simona M SM Radboud - - 2014
Pulmonary and systemic organ injury produced by oxidative stress including lipid peroxidation is a fundamental tenet of ischemia/reperfusion injury, inflammatory response to cardiac surgery and cardiopulmonary bypass (CPB) but is not routinely measured in a surgically relevant time frame. To initiate a paradigm shift towards non-invasive and real-time monitoring of ...
Della Rocca Domenico G DG 1 Department of Internal Medicine, Division of Cardiology. University of Rome "Tor Vergata". Rome, Italy. 2 Department of Cardiology, San Filippo Neri Hospital, Rome, Italy 3Texas Cardiac Arrhythmia Institute at St. David's Medical Center. Austin, TX. USA. 4 Department of Biomedical Engineering, University of Texas, Austin, Texas, USA. 5 Department of Cardiology, University of Foggia, Italy. 6 Albert Einstein College of Medicine at Montefiore Hospital, New York, - - 2014
Arrhythmia-induced cardiomyopathy is a partially or completely reversible form of myocardial dysfunction due to sustained supraventricular and ventricular arrhythmias. Asynchrony, rapid cardiac rates and rhythm irregularities are the main factors involved in the development of the disease. The reversible nature of arrhythmia-induced cardiac dysfunction allows only for a retrospective diagnosis ...
Li Quan Q Department of Cardiology, Beijing An Zhen Hospital, Capital Medical University, Beijing, - - 2014
The effects of revascularization extent (RE) on the long-term prognosis of patients with stable angina pectoris and 3-vessel disease who underwent percutaneous coronary intervention were unknown. The study was aimed at evaluating whether there was an effect of RE on patients presenting with stable angina pectoris and 3-vessel disease. RE, ...
Jiang Luyang L Department of Anesthesia and Pain Medicine Peking University People's Hospital, Beijing, China; Department of Anesthesia, Critical Care and Pain Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, - - 2014
In this study, the authors sought to investigate the extent and timing of changes in mitral annular area during the cardiac cycle. Particularly, the authors assessed whether these changes were limited to the posterior part of the annulus or were more global in nature. Prospective, observational study SETTING: Tertiary care ...
Schmitt Boris B Department of Congenital Heart Disease/Pediatric Cardiology, Deutsches Herzzentrum Berlin, Germany. Electronic address: - - 2014
Anomalous left coronary artery from the pulmonary artery (ALCAPA) is a rare congenital heart defect. We aimed to examine the role of cardiac magnetic resonance imaging (MRI) in the long-term surveillance of repaired ALCAPA with regard to myocardial scarring, wall motion abnormalities, perfusion deficits, and myocardial function. Twenty-one patients after direct ...
Dipchand Anne I AI Hospital for Sick Children, University of Toronto, Toronto, Ontario, - - 2014
Cardiac remodeling is associated with plasma biomarkers of fibrinogenesis, inflammation, and oxidative stress, and upregulation of mitogenic, pro-fibrotic, and apoptotic signaling pathways. Our primary objective was to evaluate biomarker and subcellular myocardial changes in pediatric heart transplant recipients. Fifty-two-week prospective, randomized (tacrolimus, Tac, vs. cyclosporine, CsA), open-label, parallel group study. ...
Ishigaki Takako T Department of Health Sciences, Division of Functional Diagnostics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan; Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Otsu, Shiga, - - 2014
There have been no reports that show significant direct relationship between echocardiographic parameters and B-type natriuretic peptide (BNP) level. This could be due to the heterogeneous pathophysiology of heart failure and a lack of appropriate echocardiographic parameters. We sought to determine the best echocardiographic parameter that described elevated BNP level ...
Janahmadi Zeinab Z Cardiovascular Pharmacology Research Lab, Medical School, Shiraz University of Medical Sciences, Shiraz, 7134845794, - - 2014
Myocardial infarction causes a cascade of events, which leads to heart failure, debilitation and death. This study examined possible cardioprotective effect of oleuropein in rats with acute myocardial infarction. Male Sprague-Dawly rats were allocated to five groups: sham, myocardial infarction receiving vehicle, and three myocardial infarction receiving oleuropein at 10, ...
Shah Amil M AM Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA - - 2014
-Abnormalities in cardiac structure and function in heart failure with preserved ejection fraction (HFpEF) may help identify patients at particularly high risk for cardiovascular morbidity and mortality. -Cardiac structure and function were assessed by echocardiography in a blinded core laboratory at baseline in 935 patients with HFpEF (left ventricular ejection ...
Hammadah Muhammad M Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland - - 2014
Ceruloplasmin (Cp) is a copper-binding acute-phase protein that is increased in inflammatory states and deficient in Wilson's disease. Recent studies demonstrate increased levels of Cp are associated with increased risk of developing heart failure. Our objective is to test the hypothesis that serum Cp provides incremental and independent prediction of ...
Gialdini Gino G Feil Family Brain and Mind Research Institute, Weill Cornell Medical College, New York, New - - 2014
Clinically apparent atrial fibrillation increases the risk of ischemic stroke. In contrast, perioperative atrial fibrillation may be viewed as a transient response to physiological stress, and the long-term risk of stroke after perioperative atrial fibrillation is unclear. To examine the association between perioperative atrial fibrillation and the long-term risk of ...
Mutoh Tatsushi - - 2014
IntroductionTakotsubo cardiomyopathy (TCM) is a life-threatening systemic consequence early after subarachnoid hemorrhage (SAH), but precise hemodynamics and related outcome have not been studied. The purpose of this study was to investigate the TCM-induced cardiac function by transpulmonary thermodilution and its impact on clinical outcome of SAH.MethodsWe retrospectively analyzed 46 consecutive ...
Kato Hiroyuki H Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan; Division of Cardiology, Japan Community Healthcare Organization Chukyo Hospital, Nagoya, - - 2014
Cardiac resynchronization therapy (CRT) improves cardiac function, but CRT recipients with advanced heart failure (HF) do not always respond well. Because the best parameters for the prediction of CRT response are not established, we investigated whether improvement of invasive left ventricular (LV) hemodynamic diastolic parameters could identify CRT responders. A ...
Hale Sharon L SL The Heart Institute, Good Samaritan Hospital, 1225 Wilshire Blvd, Los Angeles, CA, 90017, USA, - - 2014
Ranolazine, an inhibitor of the late current of the cardiac action potential (late INa), is a well established clinical treatment for chronic angina. The late INa in cardiac myocytes also plays an important role in the pathophysiology of acute myocardial ischemia and reperfusion, and thus is a potential therapeutic target ...
DeNicola Megan M Roger Williams Medical - - 2014
We have demonstrated that GLP-1 improved myocardial functional recovery in acute myocardial ischemic injury. However, whether stimulation of GLP-1 receptor (GLP-1R) with exendin-4, a selective GLP-1R agonist, could initiate a protective effect in the heart remains to be determined. Mouse myocardial infarction (MI) was created by ligation of the left ...
Tomai Fabrizio F Department of Cardiovascular Sciences, European Hospital, - - 2014
Objectives: To evaluate the performance of biolimus-eluting stent (BES) in patients with ST- elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI) in a real world clinical scenario. Background: Randomized studies suggest that the BES with biodegradable polymer is more effective and safe than early generation coronary stents in patients ...
Kim Eun Young EY Center for Stem Cell Engineering, Department of Basic Research Laboratories, Texas Heart Institute at St. Luke's Episcopal Hospital, 6770 Bertner Avenue, MC 2-255, Houston, TX 77030, - - 2014
Cardiomyopathy presents a major health issue and is a leading cause of heart failure. Although a subset of familial cardiomyopathy is associated with genetic mutations, over 50% of cardiomyopathy is defined as idiopathic, the mechanisms underlying which are under intensive investigation. SUMO conjugation is a dynamic posttranslational modification that can ...
Roh Jae-Il JI Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 120-749, South Korea; Yonsei Laboratory Animal Research Center, Yonsei University, Seoul 120-749, South - - 2014
Dilated cardiomyopathy (DCM) is a progressive heart disease characterized by left ventricular dilation and contractile dysfunction. Although many candidate genes have been identified with mouse models, few of them have been shown to be associated with DCM in humans. Germline depletion of Ncoa6, a nuclear hormone receptor coactivator, leads to ...
Xu Lili L Department of Anesthesiology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, - - 2014
This study was designed to determine the effects of dexmedetomidine on perioperative myocardial injury by observing peripheral circulatory changes in response to tracheal intubation and extubation, myocardial enzyme levels, myocardial ischemia improvements, cardiovascular adverse events and cytokines in patients with coronary heart disease (CHD) undergoing non-cardiac surgery. This study was ...
Filgueiras-Rama David D Department of Cardiology, La Paz University Hospital, Madrid, Spain; Atherothrombosis, Imaging and Epidemiology Department, National Center for Cardiovascular Research (CNIC), Madrid, - - 2014
New electrophysiology tools like intracardiac echocardiography (ICE) might help to minimize and early detect complications during cardiac ablation procedures. The aim of the study was to assess the utility and vascular safety of ICE during catheter ablation of complex cardiac arrhythmias in a medium-volume training center. Prospective, observational study consisted ...
Hwang Hui-Jeong HJ Department of Cardiology, Kyung Hee University School of Medicine, Kyung Hee University Hospital at Gangdong, Seoul, - - 2014
In this report, we introduce a case of thickening of the involved left ventricular apical segment on echocardiography and deep T-wave inversions in precordial leads on electrocardiography transiently seen in the course of recovery from biventricular takotsubo cardiomyopathy, mimicking apical hypertrophic cardiomyopathy. This result suggests that the echocardiographic finding of ...
Stegman Brian B Department of Cardiovascular Medicine, Cleveland Clinic, Ohio, - - 2014
Mortality from cardiogenic shock complicating acute myocardial infarction (MI) remains high despite contemporary treatment. Therapeutic Hypothermia (TH) offers cardiovascular and systemic effects that may prove beneficial in this population, however, current data are limited. This study sought to evaluate the effect of therapeutic hypothermia on serial hemodynamics obtained in subjects ...
Felician Giulia G Molecular Medicine, International Centre for Genetic Engineering and - - 2014
Rationale: The Notch pathway plays a key role in stimulating mammalian cardiomyocyte proliferation during development and in the early postnatal life; in adult zebrafish, reactivation of this pathway is also essential to drive cardiac regeneration after injury. Objective: We wanted to assess efficacy of Notch pathway stimulation in neonatal and ...
Ng Fu Siong FS Department of Biomedical Engineering, Washington University in Saint Louis, Saint Louis, MO & National Heart and Lung Institute, Imperial College London, London, United - - 2014
-Ventricular arrhythmias occur more frequently in heart failure during episodes of ischemia-reperfusion (I-R), although the mechanisms underlying this in humans are unclear. We assessed, in explanted human hearts, the remodeled electrophysiological response to acute I-R in heart failure, and its potential causes, including the remodeling of metabolic gene expression. -We ...
Korley Frederick K FK The Department of Emergency Medicine, Baltimore, - - 2014
With clinical use of high-sensitivity troponin I (hsTnI), more frequent troponin elevations will occur. However, the burden and implications of these elevations are not well understood. The authors quantified the prevalence of elevated hsTnI in patients presenting with possible acute coronary syndrome (ACS) who do not have elevated troponin with ...
Wang Ken K Computer Science Department, University of Oxford, Wolfson Building, Parks Road, Oxford, OX1 3QD, UK. Electronic address: - - 2014
Living cardiac tissue slices, a pseudo two-dimensional (2D) preparation, have received less attention than isolated single cells, cell cultures, or Langendorff-perfused hearts in cardiac biophysics research. This is, in part, due to difficulties associated with sectioning cardiac tissue to obtain live slices. With moderate complexity, native cell-types, and well-preserved cell-cell ...
Marston Nicholas A - - 2014
Impaired left ventricular diastolic filling is common in chronic thromboembolic pulmonary hypertension (CTEPH), and recent studies support left ventricular underfilling as a cause. To investigate this further, we assessed left atrial volume index (LAVI) in patients with CTEPH before and after pulmonary thromboendarterectomy (PTE). Forty-eight consecutive CTEPH patients had pre- ...
Nagashima Koichi K Arrhythmia Unit, Cardiovascular Division, Brigham and Women's Hospital, Boston, - - 2014
-Catheter ablation (CA) for ventricular arrhythmia (VA) near the distal great cardiac vein (GCV) is often challenging and data are limited. -Analysis was performed of 30 patients (19 male; age 52.8±15.5 years) who underwent CA for focal VA (11 ventricular tachycardia, 19 premature contractions) with early activation in the GCV ...
Akhundova Aysel A Marmara University Faculty of Medicine, Department of Cardiology, Istanbul, - - 2014
Variant angina (VA) is a clinical syndrome caused by spontaneous vasospasm of the epicardial coronary artery which is characterized by episodes of angina. Endothelial dysfunction and neurohormonal hyperactivity are important factors in pathogenesis of VA. Although patient prognosis is good, VA may be one of the reasons of sudden cardiac ...
Xiang Fu-Li FL Departments of Physiology and Pharmacology, Western University, London, Ontario, - - 2014
-The adult epicardium is a potential source of cardiac progenitors following myocardial infarction (MI). We tested the hypothesis that cardiomyocyte-specific overexpression of membrane-associated human stem cell factor (hSCF) enhances epicardial activation, epicardium-derived cells (EPDCs) production and myocardial arteriogenesis post-MI. -Wild-type (WT) and the inducible cardiac-specific hSCF transgenic (hSCF/tTA) mice were ...
Moretti Claudio C aDivision of Cardiology, Department of Internal Medicine, Città Della Salute e Della Scienza bCSI-Piemonte - Direzione Salute - Area Trattamento Dati cSC Programmazione e Controllo di Gestione, Turin, Italy dWegmans Pharmacy, Ithaca, New York, - - 2014
Thirty-day readmission rates after percutaneous coronary intervention (PCI) have been related to adverse prognosis, and represent one of the most investigated indicators of quality of care. These data, however, derive from non-European centers evaluating all-cause readmissions, without stratification for diagnosis. All consecutive patients undergoing PCI at our center from January ...
Gargiulo Sara - - 2014
We investigated the effects of uncoupling protein 3 (UCP3) genetic deletion on 18 F-fluorodeoxyglucose (FDG) cardiac uptake by positron emission tomography (PET)/computed tomography (CT) dedicated animal system after permanent coronary artery ligation. Cardiac 18 F-FDG PET/CT was performed in UCP3 knockout (UCP3-/-) and wild-type (WT) mice one week after induction ...
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