Search Results
Results 401 - 450 of 6440
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Zheng Minjuan M Ultrasound Department, Xijing Hospital, Fourth Military Medical University, Xi'an, - - 2014
This study aimed to evaluate the instantaneous biological response of canine myocardium in vivo to high-intensity focused ultrasound (HIFU) ablation, and thereby determine the feasibility of this method. Left ventricle myocardium HIFU ablation was performed on six dogs at four levels of HIFU energy (acoustic intensity was 3000 W/cm(2) ; ablation ...
Willis Mark M 1. The Alan Richens Welsh Epilepsy Centre, University Hospital of Wales, Heath Park, - - 2014
A 66-year-old man presented following a generalised tonic-clonic seizure and a 1 month history of paroxysmal episodes with autonomic and sensory symptoms. MRI found right medial temporal lobe swelling and high signal. Cardiac telemetry found supra-ventricular tachycardia and prolonged pauses during the paroxysmal episodes. Voltage gated potassium channel (VGKC) antibodies ...
Saguner Ardan M AM 1Department of Cardiology, University Heart Center Zurich, - - 2014
-The value of standard two-dimensional transthoracic echocardiographic (TTE) parameters for risk stratification in patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is controversial. -We investigated the impact of right ventricular fractional area change (FAC) and tricuspid annulus plane systolic excursion (TAPSE) for prediction of major adverse cardiovascular events (MACE) defined as ...
Shiba Yuji Y 1Department of Pathology, Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, - - 2014
Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) were recently shown to be capable of electromechanical integration following direct injection into intact or recently injured guinea pig hearts, and hESC-CM transplantation in recently injured hearts correlated with improvements in contractile function and a reduction in the incidence of arrhythmias. The present study ...
Spoon Daniel B DB Mayo Clinic, Rochester, - - 2014
The impact of changing demographics upon causes of long-term death after percutaneous coronary intervention (PCI) remains incompletely defined. We evaluated trends in cause-specific long-term mortality after index PCI performed at a single center from 1991-2008. Deaths were ascertained by scheduled prospective surveillance. Cause was determined via telephone interviews, medical records, ...
Haack Karla K V KK Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, - - 2014
Cheyne-Stokes respiration and cardiac arrhythmias are associated with increased morbidity and mortality in patients with chronic heart failure (CHF). Enhanced carotid body chemoreflex (CBC) sensitivity is associated with these abnormalities in CHF. Reduced carotid body (CB) nitric oxide and nitric oxide synthase (NOS) levels play an important role in the ...
Rassi Daniela do Carmo DD Faculdade de Medicina, Hospital das Clínicas, Universidade Federal de Goiás, GoiâniaGO, Brasil, Faculdade de Medicina e Hospital das Clínicas da Universidade Federal de Goiás (UFG), Goiânia, GO - - - 2014
Background: Echocardiography provides important information on the cardiac evaluation of patients with heart failure. The identification of echocardiographic parameters in severe Chagas heart disease would help implement treatment and assess prognosis. Objective: To correlate echocardiographic parameters with the endpoint cardiovascular mortality in patients with ejection fraction < 35%. Methods: Study ...
Joyce William W Zoophysiology, Department of Biosciences, Aarhus University, DK-8000 Aarhus C, Denmark; Faculty of Life Sciences, The University of Manchester, M13 9PT, UK. Electronic address: - - 2014
The few and fragmentary studies on purinergic regulation of the reptile heart have reached equivocal conclusions. Indeed, unlike fish, amphibians, and mammals, it has been suggested the turtle heart lacks purinoceptors. Here, we study the effect of adenosine and ATP on isolated heart strips from three species of reptiles: the ...
Shimamoto Shinsaku S Department of Cardiology, Osaka Medical College, Osaka, - - 2014
Mechanical discoordination (MD) is known as a myocardial deformation of opposite strain during ejection, reflecting dyssynchronous electrical activation. We used speckle tracking echocardiography to examine the relationship between MD, left ventricular (LV) function and geometry, as well as electrical dyssynchrony in various nonischemic hearts. We examined 131 subjects (left bundle branch ...
Agarwal Anushree A Aurora Cardiovascular Services, Aurora Sinai/Aurora St. Luke's Medical Centers, University of Wisconsin School of Medicine and Public Health, Milwaukee, - - 2014
Sarcoidosis is a multisystem, granulomatous disease of unknown etiology often seen in young adults, with cardiac involvement in more than one-quarter of sarcoid patients. The clinical presentation of cardiac sarcoid depends upon the location and extent of myocardium involved. Although cardiac sarcoid may produce asymmetrical septal hypertrophy, it is most ...
Linney C J CJ Department of Cardiology, Small Animal Teaching Hospital, School of Veterinary Science, University of Liverpool, Leahurst, Neston, CH64 - - 2014
To describe left atrial size, left atrial volume, left atrial function and left ventricular diastolic function in healthy cats and those with hypertrophic cardiomyopathy without and with congestive heart failure. A retrospective study of 61 client-owned, 21 healthy, 21 asymptomatic hypertrophic cardiomyopathy and 19 with hypertrophic cardiomyopathy and congestive heart ...
Ellims Andris H AH Heart Centre, Alfred Hospital, Melbourne, Victoria, Australia; Baker IDI Heart and Diabetes Research Institute, Melbourne, Victoria, - - 2014
The purpose of this study was to use cardiac magnetic resonance (CMR) imaging and invasive left ventricular (LV) pressure-volume (PV) measurements to explore the relationship between diffuse myocardial fibrosis and indexes of diastolic performance in a cohort of cardiac transplant recipients. The precise mechanism of LV diastolic dysfunction in the presence ...
Budhram Gavin R GR Tufts University School of Medicine, Department of Emergency Medicine, Baystate Medical Center, 759 Chestnut Street, Springfield, MA 01199. Electronic address: - - 2014
Intracardiac thrombus is a well-known complication of low-flow cardiac states including acute myocardial infarction and atrial fibrillation. Little is known, however, about the formation of intracardiac (left ventricular [LV]) thrombus during the extreme low-flow state of cardiac arrest. Using a swine model of sudden cardiac arrest, we examined the sonographic ...
Cobert Michael L ML Department of Cardiovascular and Thoracic Surgery, University of Texas Southwestern Medical Center, Dallas, - - 2014
Machine perfusion of donor hearts is a promising strategy to increase the donor pool. Antegrade perfusion is effective but can lead to aortic valve incompetence and nonnutrient flow. Experience with retrograde coronary sinus perfusion of donor hearts has been limited. We tested the hypothesis that retrograde perfusion could support myocardial ...
Tanaka Yoshio Y Kanazawa University Graduate School of Medicine, Kanazawa, Ishikawa; Tsuruga Municipal Hospital, Tsuruga, Fukui, - - 2014
Dispatcher-assisted cardiopulmonary resuscitation (DA-CPR) attempts to improve the management of out-of-hospital cardiac arrest (OHCA) by laypersons who are unable to recognize cardiac arrest and are unfamiliar with CPR. Therefore, we investigated the sensitivity and specificity of our new DA-CPR protocol for achieving implementation of bystander CPR in OHCA victims not ...
Oguayo Kevin N KN Department of Internal Medicine, Baylor Scott & White Healthcare, Temple, Texas; College of Medicine, Texas A&M University Health Science Center, Temple, - - 2014
Flecainide is recommended as a first-line antiarrhythmic drug to maintain normal sinus rhythm in patients with atrial fibrillation (AF) who have structurally normal hearts or hypertension without left ventricular hypertrophy. Flecainide is a sodium channel blocker with minimal effects expected on ventricular repolarization. We describe the case of a 32-year-old ...
Huang Bingqing - - 2014
Mesenchymal stem cells (MSCs) have potential for the treatment of myocardial infarction. However, several meta-analyses revealed that the outcome of stem cell transplantation is dissatisfactory. A series of studies demonstrated that the combination of cell- and gene therapy was a promising strategy to enhance therapeutic efficiency. The aim of this ...
Li Zi-Lun - - 2014
Obesity associated with metabolic derangements (ObM) worsens the prognosis of patients with coronary artery stenosis (CAS), but the underlying cardiac pathophysiologic mechanisms remain elusive. We tested the hypothesis that ObM exacerbates cardiomyocyte loss distal to moderate CAS. Obesity-prone pigs were randomized to 4 groups (n=6 each): lean-sham, ObM-sham, lean-CAS, and ...
Maréchaux Sylvestre S Université Lille Nord de France/GCS-Groupement des Hôpitaux de l'Institut Catholique de Lille/Faculté Libre de Médecine, Cardiology Department, Université Catholique de Lille, Lille, France. Electronic address: - - 2014
Previous studies have demonstrated variable patterns of longitudinal septal deformation in patients with left ventricular (LV) dysfunction and left bundle branch block. This prospective single center study was designed to assess the relationship between septal deformation patterns obtained by two-dimensional speckle-tracking echocardiography and response to cardiac resynchronization therapy (CRT). One ...
Schober A A Department of Emergency Medicine, Medical University of Vienna - - 2014
Accidental hypothermic cardiac arrest is associated with unfortunate prognosis and large studies are rare. We therefore have performed an outcome analysis in patients that were admitted to Vienna University Hospital with the diagnosis of accidental hypothermic cardiac arrest. This study employed a retrospective outcome analysis of prospectively collected data in ...
Chalkias Athanasios A MSc "Cardiopulmonary Resuscitation", Medical School, National and Kapodistrian University of Athens, Athens, Greece; Hellenic Society of Cardiopulmonary Resuscitation, Athens, Greece. Electronic address: - - 2014
This review focuses on the presentation of the emerging technology of Metabolomics, a promising tool for the detection of identifying the unrevealed biological pathways that lead to cardiac arrest. Data sources: The electronic bases of PubMed, Scopus, and EMBASE were searched. Research terms were identified using the MESH database and ...
Metwally Amr Hany AH Mansoura University, Mansoura, Egypt. Electronic address: - - 2014
It is well known that chronic hepatitis C is associated with insulin resistance and metabolic syndrome which are risk factors for atherosclerosis and coronary heart disease. As a result, chronic hepatitis C might be thought, through its association with metabolic syndrome, to increase the risk of myocardial infarction. However, unexpectedly ...
Witayavanitkul Namthip N Loyola University Chicago, United - - 2014
Myocardial infarction (MI) is associated with depressed cardiac contractile function and progression to heart failure. Cardiac myosin binding protein-C (cMyBP-C), a cardiac-specific myofilament protein, is proteolyzed post-MI in humans, which results in an N-terminal fragment, C0-C1f. The presence of C0-C1f in cultured cardiomyocytes results in decreased Ca2+ transients and cell ...
Xu Zhihui - - 2014
Objective: Uncontrolled therapeutic gene expression and neovascularization in non-specific tissues has lowered the safety of gene therapy. The aim of the study was to identify a cardiac-specific promoter to control target gene expression in heart tissue in vitro and in vivo. Methods: Adenovirus vectors containing the firefly luciferase or hepatocyte ...
Tilton Richard K RK Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Temple University School of Medicine, Philadelphia, - - 2014
Pallister-Killian syndrome (PKS) is a sporadic multisystem genetic diagnosis characterized by facial dysmorphia, variable developmental delay and intellectual impairment, hypotonia, hearing loss, seizures, differences in skin pigmentation, temporal alopecia, diaphragmatic hernia, congenital heart defects, and other systemic abnormalities. Although congenital heart defects have been described in association with PKS, the ...
Chan W Y Wandy WY Cardiology Department, Christchurch Hospital, Christchurch, New - - 2014
We hypothesized that left atrial pressure (LAP) obtained by a permanent implantable sensor is sensitive to changes in cardiac resynchronization therapy (CRT) settings and could guide CRT optimization to improve the response rate. We investigated the effect of CRT optimization on LAP and its waveform parameters in ambulant heart failure ...
Clerico Aldo - - 2014
Abstract Although the perioperative event rate has declined over the past 30 years, as a consequence of the developments in anesthesiology and surgical techniques, perioperative cardiovascular complications are still a significant clinical problem. At the end of the last century, a pooled analysis of several large studies found a 30-day ...
De Ferrari Gaetano M GM Department of Cardiology, Fondazione IRCCS Policlinico San Matteo, Viale Golgi, 19, 27100, Pavia, Italy, - - 2014
Heart failure (HF) is accompanied by an autonomic imbalance that is almost always characterized by both increased sympathetic activity and withdrawal of vagal activity. Experimentally, vagal stimulation has been shown to exert profound antiarrhythmic activity and to improve cardiac function and survival in HF models. A open-label pilot clinical study ...
Shimizu Masato M Department of Cardiology, Yokohama Minami Kyosai - - 2014
Background: The J wave and fragmented QRS (fQRS) on electrocardiography are suggested to be closely related to cardiac arrhythmogenesis. Takotsubo cardiomyopathy (TTC) occasionally causes fatal cardiac conditions including life-threatening ventricular arrhythmia. There has been, however, only 1 case report describing the J wave in TTC, and fQRS has not been reported ...
Perez Pierre P (1) CHU Nancy, Service de Réanimation Médicale Brabois; Pole Cardiovasculaire et Réanimation Médicale, Hôpital Brabois; 54511 Vandoeuvre les Nancy, France (2) INSERM, Groupe Choc, U1116, Faculté de Médecine, 54511 Vandoeuvre les Nancy, France (3) Université de Lorraine, 54000, Nancy - - 2014
There is very little data regarding the effects of norepinephrine up-titration on global and regional hemodynamics in cardiogenic shock.We studied twenty-five patients with shock secondary to myocardial infarction successfully treated with percutaneous coronary intervention. Before the inclusion, 16/25 patients presented a cardiac arrest in the presence of medical staff. Norepinephrine ...
Bian Weining W Department of Biomedical Engineering, Duke University, 3000 Science Dr, Hudson Hall 136, Durham, NC 27708, - - 2014
Complex three-dimensional (3-D) heart structure is an important determinant of cardiac electrical and mechanical function. In this study, we set to develop a versatile tissue-engineered system that can promote important aspects of cardiac functional maturation and reproduce variations in myofiber directions present in native ventricular epicardium. We cultured neonatal rat ...
Perlini Stefano S aDepartment of Internal Medicine bAmyloidosis Research and Treatment Center and Department of Molecular Medicine, Fondazione IRCCS San Matteo, University of Pavia, Pavia cIntensive Cardiac Care Unit, Heart and Vessel Department dInternal Medicine Department, University of Florence, Florence eInstitute of Cardiology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, - - 2014
Cardiac amyloidosis represents an archetypal form of restrictive heart disease, characterized by profound diastolic dysfunction. As ejection fraction is preserved until the late stage of the disease, the majority of patients do fulfill the definition of diastolic heart failure, that is, heart failure with preserved ejection fraction (HFpEF). In another ...
Wang Haibin H Department of Advanced Interdisciplinary Studies, Institute of Basic Medical Sciences, Tissue Engineering Research Center, Academy of Military Medical Sciences, 27 Taiping Road, Beijing 100850, PR - - 2014
The ability to restore heart function by replacement of diseased myocardium is one of the great challenges in biomaterials and regenerative medicine. Brown adipose derived stem cells (BADSCs) present a new source of cardiomyocytes to regenerate the myocardium after infarction. In this study, we explored an injectable tissue engineering strategy ...
Soussi Sabri S Department of Anesthesiology and Critical Care Unit, Assistance Publique Hôpitaux de Paris, Groupe Hôspitalier Saint-Louis-Lariboisiere. Paris-Diderot University, Paris, - - 2014
In the perioperative period, acute heart failure can result from a variety of conditions, and treatment may vary considerably depending on its mechanism. This review aims to provide conceptual framework by selectively presenting recent knowledge and advances in acute heart failure therapies including drugs (inotropes, diuretics) and devices (mechanical assistance, ...
Song Young Bin YB Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of - - 2014
The authors sought to investigate whether the impact of treatment strategies on clinical outcomes differed between patients with left main (LM) bifurcation lesions and those with non-LM bifurcation lesions. Few studies have considered anatomic location when comparing 1- and 2-stent strategies for bifurcation lesions. We compared the prognostic impact of ...
Deniz Acar R R Kartal Kosuyolu Education and Research Hospital, Cardiology Department, Mevlanakapi Mah. Dingil Sok. No: 23/5, Sehremini/Fatih, Istanbul, Turkey. Electronic address: - - 2014
The objective of this study was to analyze the effects of cardiac rehabilitation (CR) on the atrial function of patients with acute myocardial infarction (AMI) who had been successfully revascularized through percutaneous coronary intervention (PCI). Forty-two AMI patients having undergone CR were enrolled in this observational study. Assessments were performed ...
Frantz Stefan S Department of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany, Comprehensive Heart Failure Center, University Hospital Würzburg, Würzburg, - - 2014
Cardiac macrophages are abundant in the healthy heart and after myocardial infarction (MI). Different macrophage phenotypes likely promote myocardial health versus disease. Infarct macrophages are inflammatory and derive from circulating monocytes produced by the hematopoietic system. These cells are centrally involved in inflammatory tissue remodeling, resolution of inflammation during post-MI ...
Jiang Shuxia S Department of Internal Medicine, University of Iowa, Iowa City, IA, USA - - 2014
Ischemic preconditioning (IPC) is an adaptive mechanism that renders the myocardium resistant to injury from subsequent hypoxia. Although reactive oxygen species (ROS) contribute to both the early and late phases of IPC, their enzymatic source and associated signaling events are incompletely understood. Our objective is to investigate the role of ...
Sharma Abhishek A Department of Medicine, Maimonides Medical Center, 1016 50th Street Apt 2C, Brooklyn, NY, 11219, USA, - - 2014
Left ventricular (LV) pseudo aneurysm is a contained rupture of ventricular wall by adherent pericardium or scar tissue. We present a case of a 70 year-old male presented with exertional dyspnea for 2 months and found to have giant LV pseudo aneurysm on transthoracic echocardiogram, cardiac MRI and angiogram. To our knowledge ...
Kolseth Solveig Moss SM Dept. of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, - - 2014
Since few studies have presented a thorough analysis of the effect of levosimendan (LEV) on contractility, our purpose was to investigate in vivo cardiac function as well as in vitro cardiomyocyte function and calcium (Ca(2+) ) handling following LEV treatment. Rats with post-myocardial infarction heart failure (HF) induced by ligation ...
Thibault Bernard B Montreal Heart Institute / Université de Montréal, Montreal, Quebec, Canada. Electronic address: - - 2014
Invasively measured maximum increase in left ventricular (LV) pressure (LV dP/dtmax) has been used to assess biventricular (BiV) pacing. We quantified extra-cardiac factors contributing to its variability, and developed a protocol to minimize these effects in an acute pacing experiment. Continuous pressure was recorded by guidewire sensor placed in the ...
White David A DA Baker IDI Heart and Diabetes Institute, Australia; Department of Cardiovascular Medicine, Alfred Hospital, - - 2014
Myocardial infarction (MI) provokes regional inflammation which facilitates the healing, whereas excessive inflammation leads to adverse cardiac remodelling. Our aim was to determine the role of macrophage migration inhibitory factor (MIF) in inflammation and cardiac remodelling following MI. Wild type (WT) or global MIF deficient (MIFKO) mice were subjected to ...
Li Ming-Hui MH Division of Cardiovascular Medicine, Department of Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, - - 2014
Cardiac hypertrophy is a maladaptive change in response to pressure overload, and is also an important risk for developing heart failure. Berberine is known to have cardioprotective effects in patients with hypertension and in animal models of cardiac hypertrophy. In the current study, we observed that transverse aortic contraction (TAC) ...
Wolak Talya T aHypertension Unit bClinical Research Center cCardiology Department, Soroka University Medical Center dFaculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, - - 2014
The aim of the current study was to evaluate the effect of α blockers on the cardiac outcomes of hypertensive patients who underwent myocardial perfusion imaging (MPI). A retrospective analysis of the nuclear cardiology laboratory database was performed. The study group included only hypertensive patients (nā€Š=ā€Š19ā€Š495). The cohort was divided ...
Tanaka Akihito A Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan. Electronic address: - - 2014
Diabetic retinopathy has been identified as a predictor of cardiovascular events and heart failure in patients with diabetes mellitus (DM). This study aimed to assess the impact of diabetic retinopathy on the incidence of late cardiac events following percutaneous coronary intervention. We enrolled 88 consecutive DM patients who underwent elective ...
Xie Jing J Institute of Biomechanics and Medical Engineering, Department of Engineering Mechanics, Tsinghua University, Beijing, 100084, China; These authors contribute equally to this - - 2014
Cardiac fibrosis, an important pathological feature of structural remodeling, contributes to ventricular stiffness, diastolic dysfunction, arrhythmia, and may even lead to sudden death. Matrix stiffness, one of the many mechanical factors acting on cells, is increasingly appreciated as an important mediator to myocardial cell behavior. Here we fabricated PDMS substrates ...
D'Onofrio Antonio A Azienda Ospedaliera dei Colli - Monaldi, - - 2014
The left ventricular (LV) pacing site and the magnitude of the electrical delay within the LV, as expressed by prolonged QRS duration, are major determinants of cardiac resynchronization therapy (CRT) efficacy. We investigated the incremental value of positioning the LV lead in areas of late activation in order to enhance ...
Auricchio Angelo A Division of Cardiology, Fondazione Cardiocentro Ticino, Via Tesserete 48, CH-6900 Lugano, - - 2014
Left ventricular (LV) endocardial pacing may address the limitations in the selection of an LV pacing site and provide improvements in cardiac resynchronization therapy (CRT) effectiveness. We report on the feasibility, the safety, and the short-term outcome of a leadless ultrasound-based technology for LV endocardial resynchronization in heart failure (HF) ...
Chen Yanbo Y Department of Cardioangiology (South Area), Weifang People's Hospital, Weifang, Shandong, - - 2014
Ghrelin is an endogenous ligand of the growth hormone (GH) secretagogue receptor and is closely associated with chronic heart failure (CHF). We undertook this study to investigate the relevance of ghrelin in CHF prognosis. A total of 145 in-patients with CHF in NYHA class II, III or IV despite optimized ...
Rosen Lauren E LE Department of Pathology, Rush University Medical Center, Chicago, IL 60612, USA. Electronic address: - - 2014
Intravascular polymer emboli have been reported in the skin, lungs, and brain following vascular procedures utilizing hydrophilic polymer coated devices. The Cook arterial introducer sheath was the first of these devices to be introduced, after which case reports followed documenting sterile inflammation at the sheath access site, characterized histologically by ...
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