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Ma Sai S Department of Cardiology, Chinese PLA General Hospital, 28# Fuxing Street, Beijing, 100852, China; Department of Cardiology, Xijing Hospital,Fourth Military Medical University, 127# Changle West Road, Xi`an, Shaanxi, 710032, - - 2014
Autophagy is an intracellular process responsible for damaged or unnecessary proteins and organelles degradation. In the heart, autophagy occurs at basal level and dysregulated autophagy is associated with a variety of cardiovascular diseases. Autophagy is enhanced in ischemia as well as reperfusion phase during cardiac ischemia reperfusion (I/R) injury. More ...
Gálvez-Montón Carolina - - 2014
Despite recent advances, myocardial infarction (MI) remains the leading cause of death worldwide. Pre-clinical animal models that closely mimic human MI are pivotal for a quick translation of research and swine have similarities in anatomy and physiology. Here, we compared coronary surgical ligation versus coil embolization MI models in swine. ...
Noc Marko M Center for Intensive Internal Medicine, University Medical Center, Ljubljana, - - 2014
Due to significant improvement in the pre-hospital treatment of patients with out-of-hospital cardiac arrest (OHCA), an increasing number of initially resuscitated patients are being admitted to hospitals. Because of the limited data available and lack of clear guideline recommendations, experts from the EAPCI and "Stent for Life" (SFL) groups reviewed ...
Amat-Santos Ignacio J IJ Department of Cardiology, Quebec Heart & Lung Institute, Quebec City, Quebec, - - 2014
Aims: Elevated filling pressures of the left atrium (LA) are associated with poorer outcomes in patients with chronic heart failure. The V-Wave is a new percutaneously implanted device intended to decrease the LA pressure by the shunting of blood from the LA to the right atrium. This report describes the ...
Hedman K K Division of Cardiovascular Medicine, Department of Medical and Health Sciences, Faculty of Health Sciences, Linköping University, Linköping, Sweden; Department of Clinical Physiology, Heart & Medicine Centre, Linköping, - - 2014
There are relatively few studies on female athletes examining cardiac size and function and how these measures relate to maximal oxygen uptake (VO2max ). When determining sports eligibility, it is important to know what physiological adaptations and characteristics may be expected in female athletes, taking body and cardiac size into ...
Vernooy Kevin K Department of Cardiology, Maastricht University Medical Center, PO Box 5800, 6202 AZ Maastricht, - - 2014
Cardiac resynchronization therapy (CRT) emerged 2 decades ago as a useful form of device therapy for heart failure associated with abnormal ventricular conduction, indicated by a wide QRS complex. In this Review, we present insights into how to achieve the greatest benefits with this pacemaker therapy. Outcomes from CRT can ...
Hogan Matthew M Department of Biomedical Engineering, Cullen College of Engineering, University of Houston, Houston, TX, - - 2014
Only 3000 heart transplants are performed in the USA every year, leaving some 30 000-70 000 Americans without proper care. Current treatment modalities for heart failure have saved many lives yet still do not correct the underlying problems of congestive heart failure. Tissue engineering represents a potential field of study wherein a ...
Dorbala Sharmila S Noninvasive Cardiovascular Imaging Program, Heart and Vascular Center, Departments of Radiology and Medicine (Cardiology), Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, - - 2014
Cardiac amyloidosis, a restrictive heart disease with high mortality and morbidity, is underdiagnosed due to limited targeted diagnostic imaging. The primary aim of this study was to evaluate the utility of (18)F-florbetapir for imaging cardiac amyloidosis. We performed a pilot study of cardiac (18)F-florbetapir PET in 14 subjects: 5 control ...
Bhorat Ismail I Department of Obstetrics and Gynaecology, Subdepartment of Fetal Medicine, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Durban, South - - 2014
To establish gestational age-adjusted reference intervals and trends of the modified myocardial performance index (Mod-MPI), isovolumetric contraction time (ICT), isovolumetric relaxation time (IRT) and ejection time (ET) in pregnancy METHODS: A cross-sectional study using Doppler echocardiography to determine the Mod-MPI was performed on 419 fetuses from 20 to 38 weeks of ...
Liu Xinbing - - 2014
To investigate the effects of a noninvasive positive pressure ventilation therapy on cardiac structure and function in patients with coronary heart disease combined with obstructive sleep apnea/hypopnea syndrome (OSAHS). 80 coronary heart disease OSAHS patients from three hospitals in Shanghai were randomly divided into treatment (n=40) and control (n=40) groups. ...
Cocco Giuseppe G Formerly University of Basel, Ferrara and Bologna.. - - 2014
Heart failure is major public heart burden among the ageing population. Optimizing management of patients remains challenging despite many advances in therapy for this pathology. Natriuretic peptides are related to cardiac morbidity and mortality and their use to guide treatment might help. Most data on the value of natriuretic peptides-guided ...
Leischik Roman R Witten/Herdecke University Faculty of Health- School of Medicine. - - 2014
Since years there are constantly appearing reports about a potential myocardial injury induced by intensive sporting activities. The spectacular sudden deaths during marathon, football and, just recently, in the trend discipline triathlon seem to support that view. In addition, reports about the "athlete`s heart" and complications in the elderly causes ...
Räber Lorenz L From the Department of Cardiology, Bern University Hospital, Bern, Switzerland (L.R., M.T., A.M., P.W., B.M., S.W.); Cardiac Catheterization Laboratory, Rigshospitalet, Copenhagen, Denmark (H.K., T.E.); Department of Cardiology, Clinical Center of Serbia, Belgrade, Serbia (M.O.); Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland (D.H., P.J.); Bristol Heart Institute, Bristol, United Kingdom (A.B.); Thoraxcenter Twente and Twente University, Enschede, The Netherlands (C.v.B.); Division of Cardiology, University Hospital, Geneva, Switzerland (M.R.); Department of Cardiology, Triemlispital, Zurich, Switzerland (D.T.); Cardiocentro, Lugano, Switzerland (G.P.); Rabin Medical Center, Petach Tikva, Israel (R.K.); Tel Aviv University, Tel Aviv, Israel (R.K.); Kantonsspital Winterthur, Winterthur, Switzerland (K.W.); Department of Cardiology, University Hospital Zurich, Zurich, Switzerland (T.F.L., C.M.M.); and Clinical Trials Unit, Department of Clinical Research, University of Bern, Bern, Switzerland (P.J., - - 2014
This study sought to determine whether the 1-year differences in major adverse cardiac event between a stent eluting biolimus from a biodegradable polymer and bare-metal stents (BMSs) in the COMFORTABLE trial (Comparison of Biolimus Eluted From an Erodible Stent Coating With Bare Metal Stents in Acute ST-Elevation Myocardial Infarction) were ...
De Ferrari Gaetano M GM Department of Cardiology, Fondazione IRCCS Policlinico San Matteo, Pavia, - - 2014
Increased sympathetic activation and reduced parasympathetic tone are important pathophysiological contributors to the progression of heart failure, and are associated with poor outcome in patients. The aim of this study is to determine if vagal nerve stimulation (VNS) is a promising approach to modulate autonomic function and slow cardiac remodelling ...
Bennett Mosi K MK Kaufman Center for Heart Failure, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, - - 2014
-We hypothesized that S100A1 is regulated during human hypertrophy and heart failure (HF), and that it may be implicated in remodeling after left ventricular assist device (LVAD). S100A1 is decreased in animal and human HF and restoration produces functional recovery in animal models and in failing human myocytes. With the ...
Yamada Satsuki S Center for Regenerative Medicine and Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic , Stabile 5, 200 First Street SW, Rochester, MN 55905 , USA - - 2014
Cardiac dyssynchrony refers to disparity in cardiac wall motion, a serious consequence of myocardial infarction associated with poor outcome. Infarct-induced scar is refractory to device-based cardiac resynchronization therapy, which relies on viable tissue. Leveraging the prospect of structural and functional regeneration, reparative resynchronization has emerged as a potentially achievable strategy. ...
Ozturk Gulfer G Department of Biochemistry Diskapi Yildirim Beyazit Education and Research - - 2014
Early life-threatening cardiotoxicity and cardiac death have been reported after hematopoietic stem cell transplantation (HSCT). The purpose of the current study was to evaluate cardiac toxicity of conventional chemotherapy followed by HSCT with cardiac markers: heart-type fatty acid binding protein (H-FABP), glycogen phosphorylase BB (GPBB), high sensitive C reactive protein ...
Starnberg Karin K Department of Clinical Chemistry and Transfusion Medicine - - 2014
Cardiac troponin T (cTnT) is released from damaged heart tissue in patients with acute myocardial infarction. It is presumed that most cTnT is tightly bound and released following the degradation of myofibrils in necrotic cardiomyocytes, resulting in sustained increases in circulating cTnT. Evidence of a large irreversibly bound fraction is ...
De Sudeep Das - - 2014
We report a case of a 41-year-old Indian man who initially underwent an emergency coronary artery bypass grafting surgery (CABG) after presenting with an anterolateral myocardial infarction.Post-operatively he developed progressively worsening symptoms of right heart failure with increasing abdominal distension and lower limb swelling. Clinically, the patient was in NYHA ...
Priromprintr Bryant B Department of Pediatrics, Children's Hospital of Orange County, University of California, Irvine, Irvine, California; Department of Pediatrics, Children's Hospital Los Angeles, University of Southern California, Los Angeles, - - 2014
The utility of cardiopulmonary exercise testing (CPET) to define the risks of arrhythmia and sudden death in postoperative patients with congenital heart disease (CHD) remains uncertain. As part of the US Melody valve trial, prospective standardized CPET, along with echocardiography, cardiac magnetic resonance imaging, and cardiac catheterization, were performed in ...
He Fucheng F Department of Medical Laboratory, The First Affiliated Hospital, Zhengzhou University, 1# Jianshe East Road, Zhengzhou, 450052, People's Republic of China, - - 2014
MicroRNA (miRNAs) is demonstrated to be present in the blood of humans and has been increasingly suggested as a novel biomarker for various pathological processes in the heart, including myocardial infarction, myocardial remodeling and progression to heart failure. In this study, we aim to evaluate the diagnostic and prognostic value ...
Peng Yin Y Dept. of Genetics, The University of Alabama at - - 2014
MicroRNAs (miRNAs) play critical roles during development of the cardiovascular system. Blocking miRNA biosynthesis in embryonic hearts through a conditional gene inactivation approach led to differential cardiac defects depending on the Cre drivers used in different studies. The goal of this study is to reveal the cardiogenic pathway that is ...
Naruse Yoshihisa Y Cardiovascular Division, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, - - 2014
-Fatal arrhythmia is commonly observed in cardiac sarcoidosis, but clinical effects of a systematic treatment approach are still uncertain. This study sought to describe both clinical and electrophysiologic characteristics and outcomes of systematic treatment approach to ventricular tachycardia (VT) associated with cardiac sarcoidosis. -We enrolled 37 consecutive patients (11 men, ...
Sasaki Hideyuki - - 2014
Inhibition of cGMP-specific phosphodiesterase 5 (PDE5) ameliorates pathological cardiac remodeling and has been gaining attention as a potential therapy for heart failure. Despite promising results in males, the efficacy of the PDE5 inhibitor sildenafil in female cardiac pathologies has not been determined and might be affected by estrogen levels, given ...
Mallick Saumyaranjan S Department of Pathology and Cardiothoracic Surgery, All India Institute of Medical Sciences, New Delhi, - - 2014
Mesothelial incidental cardiac excrescence is a non-neoplastic tumor-like lesion commonly occurring in the intracardiac region. The exact etiology is unclear. A 32-year-old woman presented with respiratory distress on exertion. Echocardiography showed severe aortic, mitral, and tricuspid regurgitation, for which triple-valve replacement was performed. A small cardiac excrescence was found over ...
Hashimoto Makoto M Department of Cardiovascular Surgery, Tomishiro Central Hospital, Okinawa, Japan Department of Cardiovascular Surgery, Hokkaido Prefectural Kitami Hospital, Hokkaido, Japan - - 2014
Postoperative atrial fibrillation occurs in 20%-60% of patients after cardiac surgery. Recently, premature atrial contraction has been considered an initiator of atrial fibrillation. This study evaluated whether the frequency of premature atrial contractions predicts the occurrence of postoperative atrial fibrillation. The subjects of this study were 70 patients with no ...
Linsell Oliver O Department of Pharmacology and Toxicology, Otago School of Medical Sciences, University of Otago, Dunedin, New - - 2014
Hypoxia-ischemia (HI) is a model of cerebral ischemia used to model neonatal hypoxia and to study brain damage. Interpreting the results of experiments that use HI rests partly on the assumption that only the brain suffers major damage. In this study, we demonstrate that HI also has adverse consequences on ...
Lin I-Mei IM Department of Psychology, Kaohsiung Medical University, Kaohsiung 807, Taiwan. Electronic address: - - 2014
One psychopathological mechanism that links anger to coronary artery disease (CAD) is cardiac autonomic imbalance. Blood volume amplitude (BVA) and pulse transit time (PTT) are related to peripheral arterial elasticity and cardiac conduction, which are used as indirect markers for autonomic activation. The purposes of this study were to examine ...
Mizuno Atsushi A Department of Cardiology, St. Luke's International Hospital, Tokyo, Japan. Electronic address: - - 2014
Right ventricular outflow tract (RVOT) stenosis and pulmonary regurgitation (PR) are important residua and sequelae in adult tetralogy of Fallot (TOF) patients. Auscultation of the heart sound is a useful tool to detect and evaluate these lesions, but there was no previous report regarding heart sound in adult TOF. We ...
Husser Oliver O Servicio de Cardiología, Hospital Clínico Universitario de Valencia, Universitat de València, Valencia, España; Klinik für Herz- und Kreislauferkrankungen, Deutsches Herzzentrum München, Múnich, - - 2014
The incremental prognostic value of inducible myocardial ischemia over necrosis derived by stress cardiac magnetic resonance in depressed left ventricular function is unknown. We determined the prognostic value of necrosis and ischemia in patients with depressed left ventricular function referred for dipyridamole stress perfusion magnetic resonance. In a multicenter registry ...
Jones Christopher C Christopher Jones, Aadil Mubeen Lodhi, Long Bao Cao, Arjun Kumar Chagarlamudi, Assad Movahed, Department of Cardiovascular Sciences, East Carolina Heart Institute, Brody School of Medicine, East Carolina University, Greenville, NC 27858, United - - 2014
Dystrophic cardiac calcification is often associated with conditions causing systemic inflammation and when present, is usually extensive, often encompassing multiple cardiac chambers and valves. We present an unusual case of dystrophic left atrial calcification in the setting of end stage renal disease on hemodialysis diagnosed by echocardiography and computed tomography. ...
Deng Biyong B Shanghai Institute of Cardiovascular Diseases, Fudan University, Shanghai, 200032, China; Department of cardiology, Fudan University, Shanghai, 200032, - - 2014
The regenerative potential of alginate-chitosan composite in bone and cartilage tissue has been well documented, but its potential utility in cardiac tissue engineering has remained unknown. This study sought to determine whether early intramyocardial injection of alginate-chitosan could prevent left ventricular (LV) remodeling after myocardial infarction (MI), leading to a ...
Joki Nobuhiko N Department of Nephrology, Toho University Ohashi Medical Center, Tokyo, - - 2014
Whether myocardial perfusion imaging (MPI) can predict cardiac events in patients with advanced conservative chronic kidney disease (CKD) remains unclear. The present multicenter prospective cohort study aimed to clarify the ability of MPI to predict cardiac events in 529 patients with CKD and estimated glomerular filtration rates (eGFR) < 50 ml/min per 1.73(2) ...
Galyfos George G First Department of Propedeutic Surgery, University of Athens Medical School, Ippokrateion Hospital, Athens, Greece, - - 2014
This study synthesizes evidence from randomized controlled trials of the past decade regarding the relative safety of carotid endarterectomy (CEA) versus carotid angioplasty and stenting (CAS) as concerns postoperative cardiac damage. We searched Medline, Embase, and Cochrane Central through November 2013 to December 2013. We determined trial eligibility and extracted ...
Lin Zhiqiang Z Cardiology, Harvard Medical - - 2014
Rationale: Yes-Associated Protein (YAP), the terminal effector of the Hippo signaling pathway, is crucial for regulating embryonic cardiomyocyte (CM) proliferation. Objective: We hypothesized that YAP activation after myocardial infarction would preserve cardiac function and improve survival. Methods and Results: We used a cardiac-specific, inducible expression system to activate YAP in ...
Su Jin Bo JB INSERM, U955, Equipe 3 ENVA 7 avenue du General de Gaulle 94700 Maisons-Alfort, France. - - 2014
Heart rate is a fundamental determinant of cardiac function. Normally, the increase in heart rate is accompanied by increased cardiac function. But under pathological conditions such as myocardial infarction and heart failure, accelerated heart rate may become detrimental as it decreases the diastolic time for left ventricular filling and myocardial ...
Rohde David D Section of Molecular and Translational Cardiology, Department of Internal Medicine III, Heidelberg University Hospital Heidelberg University, Heidelberg, - - 2014
Members of the S100 protein family have been reported to function as endogenous danger signals (alarmins) playing an active role in tissue inflammation and repair when released from necrotic cells. Here, we investigated the role of S100A1, the S100 isoform with highest abundance in cardiomyocytes, when released from damaged cardiomyocytes ...
Zito Concetta C aCardiology Unit, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy bAurora Cardiovascular Services, Aurora Sinai/Aurora St. Luke's Medical Centers, University of Wisconsin School of Medicine and Public Health, Milwaukee, Wisconsin, USA cCardiology Unit, El Minia University Hospital, El Minia, Egypt dCardiology Unit, ARC, Santa Maria degli Angeli Hospital, Pordenone eCardiology Department, San Antonio Hospital, San Daniele del Friuli, Udine, - - 2014
We evaluated the interplay between left ventricular diastolic function and large-artery stiffness in asymptomatic patients at increased risk of heart failure and no structural heart disease (Stage A). We divided 127 consecutive patients (mean age 49 ± 17 years) with risk factors for heart failure who were referred to our laboratory to ...
Ise Takayuki T Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, - - 2014
Gadolinium-enhanced cardiovascular magnetic resonance is an emerging tool for the diagnosis of cardiac sarcoidosis (CS); however, the correlations between extent of late gadolinium enhancement (LGE) and efficacy of steroid therapy and adverse outcomes in patients with CS remain unclear. We aimed to clarify the prognostic impact of extent of LGE ...
Srivastava Nayan T NT Department of Pediatrics, Indiana University School of Medicine, Indianapolis, - - 2014
Left ventricular pseudoaneurysm is rare in children. The gold standard for treatment has been surgical repair. Here we describe a boy in whom an atypical left ventricular pseudoaneurysm was treated through staged transcatheter procedures. In addition, we highlight the importance of the pre-procedure cardiac magnetic resonance imaging in providing invaluable ...
Schultz Carlee D CD Centre for Heart Rhythm Disorders, University of Adelaide and Cardiovascular Investigation Unit, Royal Adelaide Hospital, Adelaide, - - 2014
Patients with atrial fibrillation (AF) are at an increased risk of thromboembolism and stroke primarily from the development of thrombi within the left atrial. Pathological changes in blood constituents and atrial endothelial damage promote the left atrial thrombus formation. It is not known whether factors predisposing to left atrial thrombus ...
Zamani Payman P Division of Cardiovascular Medicine, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, - - 2014
Atrial fibrillation remains the most prevalent cardiac arrhythmia, and its incidence is increasing as the population ages. Common conditions associated with an increased incidence include advanced age, hypertension, heart failure, and valvular heart disease. Patients with atrial fibrillation may complain of palpitations, fatigue, and decreased exercise tolerance or may be ...
Rotter David D Departments of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard Dallas, TX 75390, USA. Electronic address: - - 2014
Many important components of the cardiovascular system display circadian rhythmicity. In both humans and mice, cardiac damage from ischemia/reperfusion (I/R) is greatest at the transition from sleep to activity. The causes of this window of susceptibility are not fully understood. In the murine heart we have reported high amplitude circadian ...
Haldar Saptarsi M SM Case Cardiovascular Research Institute, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA; Harrington Heart & Vascular Institute, University Hospitals Case Medical Center, Cleveland, OH 44106, USA. Electronic address: - - 2014
Studies of transcriptional mechanisms in heart failure have focused heavily on roles of sequence-specific DNA-binding factors such as NFAT, MEF2 and GATA4. Recent findings have illuminated crucial functions for epigenetic regulators in the control of cardiac structural remodeling and mechanical dysfunction in response to pathological stress. Here, we review the ...
Xing Rui R Institute of Vascular Medicine, Peking University Third Hospital, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education and Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing, - - 2014
Myocardial contractility is crucial for cardiac output and heart function. But the detailed mechanisms of regulation remain unclear. In the present study, we found that HIP-55, an actin binding protein, negatively regulates myocardial contractility at the single-cell level. HIP-55 was overexpressed and knocked down in cardiomyocytes with an adenovirus infection. ...
Chen-Scarabelli Carol C Veterans Affairs Ann Arbor Health Care System, University of Michigan, Ann Arbor, - - 2014
The present study investigated the cardioprotective role of urocortin (Ucn) and its relationship with protein kinase C (PKC)ε and PKCδ in patients with (DMPs) and without (NDMPs) diabetes mellitus after on-pump cardiac surgery (OPCS). The molecular mechanisms responsible for the reported worse outcomes of DMP after OPCS remain unknown. Two ...
Gimelli Alessia A Fondazione CNR/Regione Toscana, Via Moruzzi, 1, 56124, Pisa, Italy, - - 2014
To assess the relationships between myocardial structure and function on cardiac magnetic resonance (CMR) imaging and sympathetic tone on (123)I-metaiodobenzylguanidine ((123)I-MIBG) scintigraphy early after myocardial infarction (MI). Ten patients underwent (123)I-MIBG and (99m)Tc-tetrofosmin rest cadmium zinc telluride scintigraphy 4 ± 1 days after MI. The segmental left ventricular (LV) relative radiotracer uptake of ...
Bharucha Tara T 1 Department of Paediatric Cardiology, University Hospital Southampton NHS Foundation Trust, United - - 2014
It is frequent, in the current era, to encounter congenital cardiac malformations described in terms of "cor triatriatum". But can hearts be truly found with three atrial chambers? The morphological method, emphasised by Van Praagh et al, states that structures within the heart should be defined on the basis of ...
Slagsvold Katrine Hordnes KH St. Olav's University Hospital / Norwegian University of Science and Technology - - 2014
Atrial fibrillation (AF) is the most common cardiac arrhythmia with a potential to cause serious complications. Mitochondria play central roles in cardiomyocyte function, and have been implicated in AF pathophysiology. MicroRNA (miR) are suggested to influence both mitochondrial function and the development of AF. Yet mitochondrial function and miR expression ...
Chhabra Lovely L Departments of Internal Medicine and Saint Vincent Hospital, University of Massachusetts Medical School, Worcester, MA, USA. - - 2014
Interatrial block (IAB; P-wave duration ≥ 110 ms), which represents a delay in the conduction between the atria, is a pandemic conduction abnormality that is frequently underappreciated in clinical practice. Despite its comprehensive documentation in the medical literature, it has still not received adequate attention and also not adequately described ...
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