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Results 401 - 450 of 6409
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Xu Zhihui - - 2014
Objective: Uncontrolled therapeutic gene expression and neovascularization in non-specific tissues has lowered the safety of gene therapy. The aim of the study was to identify a cardiac-specific promoter to control target gene expression in heart tissue in vitro and in vivo. Methods: Adenovirus vectors containing the firefly luciferase or hepatocyte ...
Tilton Richard K RK Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Temple University School of Medicine, Philadelphia, - - 2014
Pallister-Killian syndrome (PKS) is a sporadic multisystem genetic diagnosis characterized by facial dysmorphia, variable developmental delay and intellectual impairment, hypotonia, hearing loss, seizures, differences in skin pigmentation, temporal alopecia, diaphragmatic hernia, congenital heart defects, and other systemic abnormalities. Although congenital heart defects have been described in association with PKS, the ...
Chan W Y Wandy WY Cardiology Department, Christchurch Hospital, Christchurch, New - - 2014
We hypothesized that left atrial pressure (LAP) obtained by a permanent implantable sensor is sensitive to changes in cardiac resynchronization therapy (CRT) settings and could guide CRT optimization to improve the response rate. We investigated the effect of CRT optimization on LAP and its waveform parameters in ambulant heart failure ...
Clerico Aldo - - 2014
Abstract Although the perioperative event rate has declined over the past 30 years, as a consequence of the developments in anesthesiology and surgical techniques, perioperative cardiovascular complications are still a significant clinical problem. At the end of the last century, a pooled analysis of several large studies found a 30-day ...
De Ferrari Gaetano M GM Department of Cardiology, Fondazione IRCCS Policlinico San Matteo, Viale Golgi, 19, 27100, Pavia, Italy, - - 2014
Heart failure (HF) is accompanied by an autonomic imbalance that is almost always characterized by both increased sympathetic activity and withdrawal of vagal activity. Experimentally, vagal stimulation has been shown to exert profound antiarrhythmic activity and to improve cardiac function and survival in HF models. A open-label pilot clinical study ...
Shimizu Masato M Department of Cardiology, Yokohama Minami Kyosai - - 2014
Background: The J wave and fragmented QRS (fQRS) on electrocardiography are suggested to be closely related to cardiac arrhythmogenesis. Takotsubo cardiomyopathy (TTC) occasionally causes fatal cardiac conditions including life-threatening ventricular arrhythmia. There has been, however, only 1 case report describing the J wave in TTC, and fQRS has not been reported ...
Perez Pierre P (1) CHU Nancy, Service de Réanimation Médicale Brabois; Pole Cardiovasculaire et Réanimation Médicale, Hôpital Brabois; 54511 Vandoeuvre les Nancy, France (2) INSERM, Groupe Choc, U1116, Faculté de Médecine, 54511 Vandoeuvre les Nancy, France (3) Université de Lorraine, 54000, Nancy - - 2014
There is very little data regarding the effects of norepinephrine up-titration on global and regional hemodynamics in cardiogenic shock.We studied twenty-five patients with shock secondary to myocardial infarction successfully treated with percutaneous coronary intervention. Before the inclusion, 16/25 patients presented a cardiac arrest in the presence of medical staff. Norepinephrine ...
Bian Weining W Department of Biomedical Engineering, Duke University, 3000 Science Dr, Hudson Hall 136, Durham, NC 27708, - - 2014
Complex three-dimensional (3-D) heart structure is an important determinant of cardiac electrical and mechanical function. In this study, we set to develop a versatile tissue-engineered system that can promote important aspects of cardiac functional maturation and reproduce variations in myofiber directions present in native ventricular epicardium. We cultured neonatal rat ...
Perlini Stefano S aDepartment of Internal Medicine bAmyloidosis Research and Treatment Center and Department of Molecular Medicine, Fondazione IRCCS San Matteo, University of Pavia, Pavia cIntensive Cardiac Care Unit, Heart and Vessel Department dInternal Medicine Department, University of Florence, Florence eInstitute of Cardiology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, - - 2014
Cardiac amyloidosis represents an archetypal form of restrictive heart disease, characterized by profound diastolic dysfunction. As ejection fraction is preserved until the late stage of the disease, the majority of patients do fulfill the definition of diastolic heart failure, that is, heart failure with preserved ejection fraction (HFpEF). In another ...
Wang Haibin H Department of Advanced Interdisciplinary Studies, Institute of Basic Medical Sciences, Tissue Engineering Research Center, Academy of Military Medical Sciences, 27 Taiping Road, Beijing 100850, PR - - 2014
The ability to restore heart function by replacement of diseased myocardium is one of the great challenges in biomaterials and regenerative medicine. Brown adipose derived stem cells (BADSCs) present a new source of cardiomyocytes to regenerate the myocardium after infarction. In this study, we explored an injectable tissue engineering strategy ...
Soussi Sabri S Department of Anesthesiology and Critical Care Unit, Assistance Publique Hôpitaux de Paris, Groupe Hôspitalier Saint-Louis-Lariboisiere. Paris-Diderot University, Paris, - - 2014
In the perioperative period, acute heart failure can result from a variety of conditions, and treatment may vary considerably depending on its mechanism. This review aims to provide conceptual framework by selectively presenting recent knowledge and advances in acute heart failure therapies including drugs (inotropes, diuretics) and devices (mechanical assistance, ...
Song Young Bin YB Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of - - 2014
The authors sought to investigate whether the impact of treatment strategies on clinical outcomes differed between patients with left main (LM) bifurcation lesions and those with non-LM bifurcation lesions. Few studies have considered anatomic location when comparing 1- and 2-stent strategies for bifurcation lesions. We compared the prognostic impact of ...
Deniz Acar R R Kartal Kosuyolu Education and Research Hospital, Cardiology Department, Mevlanakapi Mah. Dingil Sok. No: 23/5, Sehremini/Fatih, Istanbul, Turkey. Electronic address: - - 2014
The objective of this study was to analyze the effects of cardiac rehabilitation (CR) on the atrial function of patients with acute myocardial infarction (AMI) who had been successfully revascularized through percutaneous coronary intervention (PCI). Forty-two AMI patients having undergone CR were enrolled in this observational study. Assessments were performed ...
Frantz Stefan S Department of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany, Comprehensive Heart Failure Center, University Hospital Würzburg, Würzburg, - - 2014
Cardiac macrophages are abundant in the healthy heart and after myocardial infarction (MI). Different macrophage phenotypes likely promote myocardial health versus disease. Infarct macrophages are inflammatory and derive from circulating monocytes produced by the hematopoietic system. These cells are centrally involved in inflammatory tissue remodeling, resolution of inflammation during post-MI ...
Jiang Shuxia S Department of Internal Medicine, University of Iowa, Iowa City, IA, USA - - 2014
Ischemic preconditioning (IPC) is an adaptive mechanism that renders the myocardium resistant to injury from subsequent hypoxia. Although reactive oxygen species (ROS) contribute to both the early and late phases of IPC, their enzymatic source and associated signaling events are incompletely understood. Our objective is to investigate the role of ...
Sharma Abhishek A Department of Medicine, Maimonides Medical Center, 1016 50th Street Apt 2C, Brooklyn, NY, 11219, USA, - - 2014
Left ventricular (LV) pseudo aneurysm is a contained rupture of ventricular wall by adherent pericardium or scar tissue. We present a case of a 70 year-old male presented with exertional dyspnea for 2 months and found to have giant LV pseudo aneurysm on transthoracic echocardiogram, cardiac MRI and angiogram. To our knowledge ...
Kolseth Solveig Moss SM Dept. of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, - - 2014
Since few studies have presented a thorough analysis of the effect of levosimendan (LEV) on contractility, our purpose was to investigate in vivo cardiac function as well as in vitro cardiomyocyte function and calcium (Ca(2+) ) handling following LEV treatment. Rats with post-myocardial infarction heart failure (HF) induced by ligation ...
Thibault Bernard B Montreal Heart Institute / Université de Montréal, Montreal, Quebec, Canada. Electronic address: - - 2014
Invasively measured maximum increase in left ventricular (LV) pressure (LV dP/dtmax) has been used to assess biventricular (BiV) pacing. We quantified extra-cardiac factors contributing to its variability, and developed a protocol to minimize these effects in an acute pacing experiment. Continuous pressure was recorded by guidewire sensor placed in the ...
White David A DA Baker IDI Heart and Diabetes Institute, Australia; Department of Cardiovascular Medicine, Alfred Hospital, - - 2014
Myocardial infarction (MI) provokes regional inflammation which facilitates the healing, whereas excessive inflammation leads to adverse cardiac remodelling. Our aim was to determine the role of macrophage migration inhibitory factor (MIF) in inflammation and cardiac remodelling following MI. Wild type (WT) or global MIF deficient (MIFKO) mice were subjected to ...
Li Ming-Hui MH Division of Cardiovascular Medicine, Department of Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, - - 2014
Cardiac hypertrophy is a maladaptive change in response to pressure overload, and is also an important risk for developing heart failure. Berberine is known to have cardioprotective effects in patients with hypertension and in animal models of cardiac hypertrophy. In the current study, we observed that transverse aortic contraction (TAC) ...
Wolak Talya T aHypertension Unit bClinical Research Center cCardiology Department, Soroka University Medical Center dFaculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, - - 2014
The aim of the current study was to evaluate the effect of α blockers on the cardiac outcomes of hypertensive patients who underwent myocardial perfusion imaging (MPI). A retrospective analysis of the nuclear cardiology laboratory database was performed. The study group included only hypertensive patients (nā€Š=ā€Š19ā€Š495). The cohort was divided ...
Tanaka Akihito A Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan. Electronic address: - - 2014
Diabetic retinopathy has been identified as a predictor of cardiovascular events and heart failure in patients with diabetes mellitus (DM). This study aimed to assess the impact of diabetic retinopathy on the incidence of late cardiac events following percutaneous coronary intervention. We enrolled 88 consecutive DM patients who underwent elective ...
Xie Jing J Institute of Biomechanics and Medical Engineering, Department of Engineering Mechanics, Tsinghua University, Beijing, 100084, China; These authors contribute equally to this - - 2014
Cardiac fibrosis, an important pathological feature of structural remodeling, contributes to ventricular stiffness, diastolic dysfunction, arrhythmia, and may even lead to sudden death. Matrix stiffness, one of the many mechanical factors acting on cells, is increasingly appreciated as an important mediator to myocardial cell behavior. Here we fabricated PDMS substrates ...
D'Onofrio Antonio A Azienda Ospedaliera dei Colli - Monaldi, - - 2014
The left ventricular (LV) pacing site and the magnitude of the electrical delay within the LV, as expressed by prolonged QRS duration, are major determinants of cardiac resynchronization therapy (CRT) efficacy. We investigated the incremental value of positioning the LV lead in areas of late activation in order to enhance ...
Auricchio Angelo A Division of Cardiology, Fondazione Cardiocentro Ticino, Via Tesserete 48, CH-6900 Lugano, - - 2014
Left ventricular (LV) endocardial pacing may address the limitations in the selection of an LV pacing site and provide improvements in cardiac resynchronization therapy (CRT) effectiveness. We report on the feasibility, the safety, and the short-term outcome of a leadless ultrasound-based technology for LV endocardial resynchronization in heart failure (HF) ...
Chen Yanbo Y Department of Cardioangiology (South Area), Weifang People's Hospital, Weifang, Shandong, - - 2014
Ghrelin is an endogenous ligand of the growth hormone (GH) secretagogue receptor and is closely associated with chronic heart failure (CHF). We undertook this study to investigate the relevance of ghrelin in CHF prognosis. A total of 145 in-patients with CHF in NYHA class II, III or IV despite optimized ...
Rosen Lauren E LE Department of Pathology, Rush University Medical Center, Chicago, IL 60612, USA. Electronic address: - - 2014
Intravascular polymer emboli have been reported in the skin, lungs, and brain following vascular procedures utilizing hydrophilic polymer coated devices. The Cook arterial introducer sheath was the first of these devices to be introduced, after which case reports followed documenting sterile inflammation at the sheath access site, characterized histologically by ...
Ishikawa T - - 2014
Opioids; i.e., compounds with morphine-like actions, and their receptors have been demonstrated to be involved in cardioprotection, at least in scientific studies, which makes sense as cardiomyocytes express most of the known opioid receptors and their agonists. In vitro and in vivo studies have demonstrated that the opioid system plays ...
Ishii Hisanari H Department of Anesthesia, Tenri Hospital, 200 Mishima-cho, Tenri, Nara 632-8555, Japan. - - 2014
Opioids; i.e., compounds with morphine-like actions, and their receptors have been demonstrated to be involved in cardioprotection, at least in scientific studies, which makes sense as cardiomyocytes express most of the known opioid receptors and their agonists. In vitro and in vivo studies have demonstrated that the opioid system plays ...
Slyngstad Tyler T Heart Research Follow-up Program of the of the Department of Medicine, University of Rochester Medical Center, Rochester, - - 2014
There are no prior studies assessing the relationship between left atrial volume and inappropriate ICD therapy following treatment with cardiac resynchronization therapy. We hypothesized that patients randomized to CRT-D in the MADIT-CRT trial who had significant left atrial volume (LAV) reductions would have reduced risks of inappropriate ICD therapy. Cardiac ...
Ellis Sheila J SJ From the Department of Anesthesiology, University of Nebraska Medical Center, Omaha, Nebraska (S.J.E., M.C.N., J.A.S., K.R.P., J.H.T., S.J.L.); Veterans Affairs Nebraska Western-Iowa Healthcare System, and Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska (D.J.R.); Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska (D.W.M.); Department of Anesthesiology, The Ohio State University Wexner Medical Center, Columbus, Ohio (R.L.H.); Department of Anesthesiology, University of Kansas Medical Center, Kansas City, Kansas (J.D.K.); and Department of Biostatistics, College of Public Health, University of Nebraska Medical Center, Omaha, Nebraska - - 2014
Much is still unknown about the actual incidence of anesthesia-related cardiac arrest in the United States. The authors identified all of the cases of cardiac arrest from their quality improvement database from 1999 to 2009 and submitted them for review by an independent study commission to give them the best ...
Naggar Isaac I Department of Physiology & Pharmacology, State University of New York Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, New York 11203, United States; Program in Neural and Behavioral Sciences, State University of New York Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, New York 11203, United - - 2014
Vagal inputs control pacemaking and conduction systems in the heart. Anatomical evidence suggests a direct ventricular action, but functional evidence that separates direct and indirect (via the conduction system) vagal actions is less well established. We studied vagus nerve stimulation (VNS) during sinus rhythm and ventricular fibrillation (VF) in pigs ...
Miloslavsky Eli - - 2014
Any cardiac tissue can be affected in most primary vasculitides. However, certain entities such as eosinophilic granulomatosis with polyangiitis (or Churg-Strauss syndrome) and Takayasu arteritis involve the heart in up to 60% of patients. Vasculitic cardiac complications are important to recognize because they have been linked to increased mortality and ...
Jang David H - - 2014
Adverse cardiovascular events comprise a large portion of the morbidity and mortality in drug overdose emergencies. Adverse cardiovascular events encountered by emergency physicians treating poisoned patients include myocardial injury, hemodynamic compromise with shock, tachydysrhythmias, and cardiac arrest. Early signs of toxin-induced cardiovascular failure include bradycardia, tachycardia, and specific ECG findings. ...
Johnson Frances L - - 2014
Heart failure is a clinical syndrome that is heterogeneous in both pathophysiology and etiology. This article describes some of the common mechanisms underlying heart failure, and reviews common causes. Informative diagnostic testing is reviewed.
Patarroyo-Aponte Maria - - 2014
Heart failure is one of the most prevalent cardiovascular diseases in the United States, and is associated with significant morbidity, mortality, and costs. Prompt diagnosis may help decrease mortality, hospital stay, and costs related to treatment. A complete heart failure evaluation comprises a comprehensive history and physical examination, echocardiogram, and ...
Maldonado Yasdet Y aDepartment of Anesthesiology, Allegheny Health Network, Pittsburgh, Pennsylvania bTemple University School of Medicine, Philadelphia, Pennsylvania, - - 2014
Neurologic injury remains a common complication in patients undergoing mechanical support for cardiac and respiratory failure with either left ventricular assist devices (LVAD) or extracorporeal membrane oxygenation (ECMO). Cerebral near-infrared spectroscopy (NIRS) has been recognized clinically as a valid, continuous, and practical monitor of cerebral perfusion in cardiac surgery. Recently, ...
Shantsila Eduard E University of Birmingham Center for Cardiovascular Sciences, City Hospital, Birmingham, B18 7QH, - - 2014
Pathophysiologically, there is a prothrombotic state evident in heart failure (HF). This is particularly evident within atria in patients whose course of the disease is complicated by concomitant atrial fibrillation (AF). A predisposition for thrombogenesis exists in patients with dilated dysfunctional cardiac chambers, such as those seen in patients with ...
Kohlhauer Matthias M *INSERM, U955, and †Université Paris-Est, UMR_S955, Créteil; ‡Université Paris Est, Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort; and §SAMU de Paris, Département d'Anesthésie Réanimation, CHU Necker Enfants Malades, Université Paris Descartes, Paris, - - 2014
Background: Therapeutic hypothermia was shown to facilitate resumption of spontaneous circulation when instituted during cardiac arrest. Here, we investigated whether it directly improved the chance of successful resuscitation independently of adrenaline administration in rabbits. We further evaluated the direct effect of hypothermia on vascular function in vitro. Methods: In a ...
Borgna-Pignatti Caterina C Department of Clinical and Experimental Medicine (Pediatrics), University of Ferrara, Ferrara, - - 2014
The age at which it is necessary to start Cardiovascular Magnetic Resonance (CMR) T2* screening in thalassaemia major (TM) is still uncertain. To clarify this point, we evaluated the prevalence of myocardial iron overload (MIO), function and fibrosis by CMR in TM patients younger than 10 years. We retrospectively selected 35 ...
Ooi Jenny Yy JY Baker IDI Heart & Diabetes Institute, PO Box 6429, St Kilda Road Central, Melbourne 8008, - - 2014
Cardiac hypertrophy is broadly defined as an increase in heart mass. Heart enlargement in a setting of cardiac disease is referred to as pathological hypertrophy and often progresses to heart failure. Physiological hypertrophy refers to heart growth in response to postnatal development, exercise training and pregnancy, and is an adaptive ...
Vest Amanda R AR Heart and Vascular Institute, Section of Heart Failure, 9500 Euclid Avenue, Mail Code J3-4, Cleveland, OH, 44195, USA, - - 2014
Obesity is a risk factor for the development of heart failure (HF), but has been associated with improved survival in patients with established HF. Weight loss should clearly be recommended and supported for obese individuals without cardiac pathology to prevent cardiomyopathy development. Clinical recommendations at the other end of the ...
Williams Elbert E EE Michigan State University College of Human Medicine - Kalamazoo Campus, Kalamazoo, - - 2014
Although myxomas are the most commonly seen primary cardiac tumors, encompassing 30% to 50% of all primary tumors of the heart, they remain a rare finding with an annual reported incidence of 0.5 per million. The presenting symptoms of an atrial myxoma are widely varied as are the clinical consequences. ...
Madder Ryan D RD Frederik Meijer Heart & Vascular Institute, Spectrum Health, 100 Michigan Street NE, Grand Rapids, MI 49503 USA. - - 2014
With an estimated 300,000 cases occurring per year in the United States alone, sudden cardiac death remains a major public health problem and in many cases is the first manifestation of coronary artery disease. Autopsy studies have established that the causative event in many cases of sudden death is rupture ...
Yar Sumeyye S Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, M/C 901, Chicago, IL, 60612, - - 2014
In this review, we address the following question: Are modifications at the level of sarcomeric proteins in acquired heart failure early inducers of altered cardiac dynamics and signaling leading to remodeling and progression to decompensation? There is no doubt that most inherited cardiomyopathies are caused by mutations in proteins of ...
Spiro Jon J Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation - - 2014
Rates of survival after cardiac arrest are low and correlate with the quality of cardiopulmonary resuscitation (CPR). Devices that deliver automated CPR (A-CPR) can provide sustained and effective chest compressions, which are especially useful during patient transfer and while simultaneous invasive procedures are being performed. The use of such devices ...
Ken Mehta Sudhir S Department of Pediatric Cardiology, Pediatric Institute, Cleveland Clinic Children's, OH, - - 2014
A cardiac-focused history and physical exam are essential before you write that prescription. But what about an EKG? Should you order one--or not?
Zhao Li-Qun LQ Shanghai Jiao Tong University affiliated first people's Hospital, Shanghai, - - 2014
Many clinical studies indicate that atrial fibrillation is closely related to hypertension. Atrial fibrillation is not only associated with the level of blood pressure (BP) but also with the circadian rhythms of BP. However, the underlying mechanisms of atrial fibrillation in essential hypertension patients remain largely unknown. Hypertension may facilitate ...
Olshansky Brian B Professor Emeritus, University of Iowa Hospitals, Iowa City and Mercy Hospital, Mason City, IA. - - 2014
Atrial fibrillation is a common, often symptomatic, and concerning arrhythmia that can lead to heart failure, decreased athletic tolerance, and thromboembolic events; it has also been associated with increased mortality. Although atrial fibrillation is an uncommon condition in younger and otherwise healthy people, recent emerging evidence indicates that endurance athletes ...
Sanderson John E JE Division of Cardiology, Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, People's Republic of China. Electronic address: - - 2014
It is well recognized that many patients presenting with heart failure have a normal left ventricular ejection fraction. There has been debate about the correct name for this condition including originally Diastolic Heart Failure (DHF), Heart Failure with a Normal Ejection Fraction (HFNEF), and more recently Heart Failure with a ...
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